Detailed information for compound 1857098

Basic information

Technical information
  • TDR Targets ID: 1857098
  • Name: N-[(Z)-1-(1,3-benzodioxol-5-yl)-3-((2E)-2-(1, 3-benzodioxol-5-ylmethylidene)hydrazinyl)-3-o xoprop-1-en-2-yl]benzamide
  • MW: 457.435 | Formula: C25H19N3O6
  • H donors: 2 H acceptors: 2 LogP: 3.93 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(/C(=C/c1ccc2c(c1)OCO2)/NC(=O)c1ccccc1)N/N=C/c1ccc2c(c1)OCO2
  • InChi: 1S/C25H19N3O6/c29-24(18-4-2-1-3-5-18)27-19(10-16-6-8-20-22(11-16)33-14-31-20)25(30)28-26-13-17-7-9-21-23(12-17)34-15-32-21/h1-13H,14-15H2,(H,27,29)(H,28,30)/b19-10-,26-13+
  • InChiKey: QGCZBHATUMZYPQ-ROHHWKQTSA-N  


Substructure search Similarity search

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Synonyms

  • N-[(Z)-1-(1,3-benzodioxol-5-yl)-3-(2-(1,3-benzodioxol-5-ylmethylidene)hydrazinyl)-3-oxoprop-1-en-2-yl]benzamide
  • N-[1-(1,3-benzodioxol-5-yl)-3-(2-(1,3-benzodioxol-5-ylmethylidene)hydrazinyl)-3-oxoprop-1-en-2-yl]benzamide
  • N-[(Z)-2-(1,3-benzodioxol-5-yl)-1-[(1,3-benzodioxol-5-ylmethyleneamino)carbamoyl]vinyl]benzamide
  • N-[2-(1,3-benzodioxol-5-yl)-1-[(1,3-benzodioxol-5-ylmethyleneamino)carbamoyl]vinyl]benzamide
  • N-[(Z)-2-(1,3-benzodioxol-5-yl)-1-[((N'E)-N'-(1,3-benzodioxol-5-ylmethylene)hydrazino)-oxomethyl]vinyl]benzamide
  • N-[(Z)-2-(1,3-benzodioxol-5-yl)-1-[(N'-(1,3-benzodioxol-5-ylmethylene)hydrazino)-oxomethyl]vinyl]benzamide
  • N-[2-(1,3-benzodioxol-5-yl)-1-[(N'-(1,3-benzodioxol-5-ylmethylene)hydrazino)-oxomethyl]vinyl]benzamide
  • N-[(Z)-1-(1,3-benzodioxol-5-yl)-3-((2E)-2-(1,3-benzodioxol-5-ylmethylidene)hydrazinyl)-3-oxo-prop-1-en-2-yl]benzamide
  • N-[(Z)-1-(1,3-benzodioxol-5-yl)-3-(2-(1,3-benzodioxol-5-ylmethylidene)hydrazinyl)-3-oxo-prop-1-en-2-yl]benzamide
  • N-[1-(1,3-benzodioxol-5-yl)-3-(2-(1,3-benzodioxol-5-ylmethylidene)hydrazinyl)-3-oxo-prop-1-en-2-yl]benzamide
  • N-[2-Benzo[1,3]dioxol-5-yl-1-(benzo[1,3]dioxol-5-ylmethylene-hydrazinocarbonyl)-vinyl]-benzamide
  • SMR000174226
  • BAS 00281912
  • MLS000562321

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cytochrome P450 family protein 0.0023 0.0631 0.0631
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0943 0.1596
Schistosoma mansoni hypothetical protein 0.0019 0.0372 0.0411
Echinococcus multilocularis muscleblind protein 0.018 1 1
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.2461 0.4163
Leishmania major DNA polymerase eta, putative 0.0038 0.1502 0.2541
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0372 0.0372
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0626 0.406
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0035 0.1303 0.1303
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Schistosoma mansoni hypothetical protein 0.0019 0.0372 0.0411
Echinococcus multilocularis muscleblind protein 1 0.018 1 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.7838 0.7838
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0626 0.1058
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0073 0.361 0.361
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0112 0.5912 0.5912
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0112 0.5912 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0173 0.0173
Echinococcus multilocularis lamin dm0 0.0033 0.1178 0.1178
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0073 0.361 0.5644
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0073 0.361 0.361
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0137
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0112 0.5912 0.5912
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0073 0.3606 0.6099
Schistosoma mansoni hypothetical protein 0.0152 0.8307 0.9194
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0112 0.5912 0.5
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.1178 0.1178
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0035 0.1303 0.2205
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0631 0.1068
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.1502 0.2541
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0943 0.1596
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0631 0.0631
Trypanosoma brucei unspecified product 0.0023 0.0626 0.1058
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0073 0.3606 0.6099
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0626 0.0626
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0943 0.0943
Echinococcus multilocularis GPCR, family 2 0.0019 0.0372 0.0372
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0035 0.1303 0.2205
Onchocerca volvulus 0.0033 0.1178 1
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0372 0.0372
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0442 0.2867
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0943 0.1596
Schistosoma mansoni hypothetical protein 0.0019 0.0372 0.0411
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.2461 0.2461
Loa Loa (eye worm) intermediate filament protein 0.0033 0.1178 0.1178
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.2461 0.4163
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0112 0.5912 0.6543
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0943 0.1596
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Echinococcus granulosus muscleblind protein 0.018 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1691 0.1691
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0112 0.5912 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0943 0.0943
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0077 0.3843 0.3843
Brugia malayi MH2 domain containing protein 0.0144 0.7838 0.7838
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Echinococcus multilocularis dna polymerase eta 0.0054 0.2461 0.2461
Schistosoma mansoni DNA polymerase eta 0.0054 0.2461 0.2724
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.2827 0.2827
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0112 0.5912 0.5912
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0943 0.1596
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.7838 0.7838
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0626 0.1058
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0039 0.1537 0.1725
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0626 0.0692
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0631 0.1068
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0631 0.0631
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0112 0.5912 1
Schistosoma mansoni hypothetical protein 0.0041 0.1691 0.1871
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0039 0.1541 1
Schistosoma mansoni thyroid hormone receptor 0.0164 0.9036 1
Echinococcus granulosus GPCR family 2 0.0019 0.0372 0.0372
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0035 0.1303 0.2205
Mycobacterium ulcerans hypothetical protein 0.0029 0.0943 0.1596
Leishmania major cytochrome p450-like protein 0.0023 0.0631 0.1068
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0112 0.5912 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Echinococcus multilocularis musashi 0.0033 0.1178 0.1178
Loa Loa (eye worm) hypothetical protein 0.0021 0.0512 0.0512
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Schistosoma mansoni lamin 0.0033 0.1178 0.1304
Loa Loa (eye worm) hypothetical protein 0.0029 0.0943 0.0943
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Loa Loa (eye worm) hypothetical protein 0.0021 0.0512 0.0512
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0077 0.3843 0.3843
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0073 0.3606 0.5638
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0442 0.2867
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0073 0.361 0.361
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1691 0.1691
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0626 0.0626
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0626 0.0626
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0442 0.2867
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0626 0.0626
Loa Loa (eye worm) hypothetical protein 0.0019 0.0372 0.0372
Echinococcus granulosus lamin 0.0033 0.1178 0.1178
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0943 0.1596
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0943 0.6122
Echinococcus granulosus intermediate filament protein 0.0033 0.1178 0.1178
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0943 0.6122
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0943 0.1596
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0112 0.5912 0.5912
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0626 0.0626
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0194 0.0328
Loa Loa (eye worm) hypothetical protein 0.0032 0.1143 0.1143
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Loa Loa (eye worm) hypothetical protein 0.0054 0.2461 0.2461
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0626 0.1058
Loa Loa (eye worm) hypothetical protein 0.0016 0.0173 0.0173
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0442 0.2867
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0631 0.1068
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0073 0.3606 0.6099
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0112 0.5912 1
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0626 0.1058
Brugia malayi Cytochrome P450 family protein 0.0023 0.0631 0.0631
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0035 0.1303 0.2205
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0073 0.3606 0.6099
Trypanosoma brucei unspecified product 0.0016 0.0194 0.0328
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.275 0.275
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0112 0.5912 0.5912
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0112 0.5912 0.6543
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.2827 0.2827
Leishmania major DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0112 0.5912 0.6543
Brugia malayi Cytochrome P450 family protein 0.0059 0.275 0.275
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0631 0.0631
Echinococcus granulosus dna polymerase eta 0.0054 0.2461 0.2461
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0039 0.1541 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.361 0.361
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.8307 0.8307
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0112 0.5912 1
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0112 0.5912 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0626 0.1058
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0035 0.1303 0.2205
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0626 0.0692
Echinococcus multilocularis lamin 0.0033 0.1178 0.1178
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0112 0.5912 1
Schistosoma mansoni hypothetical protein 0.0019 0.0372 0.0411
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0626 0.406
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0173 0.0173
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.1502 0.2541
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0943 0.0601
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0112 0.5912 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Brugia malayi intermediate filament protein 0.0033 0.1178 0.1178
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0512 0.0865
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0194 0.0328
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0112 0.5912 0.6543
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0512 0.332
Loa Loa (eye worm) hypothetical protein 0.006 0.2827 0.2827
Loa Loa (eye worm) hypothetical protein 0.0029 0.0943 0.0943
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0194 0.0328
Loa Loa (eye worm) hypothetical protein 0.0021 0.0512 0.0512
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0372 0.0372
Trypanosoma brucei unspecified product 0.0016 0.0194 0.0328
Loa Loa (eye worm) hypothetical protein 0.018 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.9036 0.9036
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0112 0.5912 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0943 0.1596
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0943 0.1596
Loa Loa (eye worm) hypothetical protein 0.0029 0.0943 0.0943
Loa Loa (eye worm) hypothetical protein 0.0021 0.0512 0.0512
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.8307 0.8307
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0372 0.0372
Leishmania major DNA polymerase eta, putative 0.0054 0.2461 0.4163
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0943 0.6122
Loa Loa (eye worm) hypothetical protein 0.018 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0112 0.5912 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0372 0.0372
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0943 0.6122
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0943 0.1596
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0631 0.1068
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0073 0.361 0.361
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0943 0.0601
Echinococcus granulosus lamin dm0 0.0033 0.1178 0.1178
Onchocerca volvulus 0.0033 0.1178 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Schistosoma mansoni lamin 0.0033 0.1178 0.1304
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0112 0.5912 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0626 0.1058
Echinococcus granulosus dna polymerase kappa 0.0023 0.0626 0.0626
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0372 0.0372
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0276 0.0276
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0276 0.0276
Schistosoma mansoni intermediate filament proteins 0.0033 0.1178 0.1304
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.1178 0.1178
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0372 0.0372
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0112 0.5912 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.2827 0.2827
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0112 0.5912 0.5
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0033 0.1178 0.1178
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0943 0.0943
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0073 0.361 0.5644
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0943 0.0601
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0112 0.5912 1
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0039 0.1537 0.1537
Loa Loa (eye worm) hypothetical protein 0.0021 0.0512 0.0512
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Schistosoma mansoni thyroid hormone receptor 0.0164 0.9036 1
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0112 0.5912 1

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 1.122018454 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 12.58925412 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 14.12537545 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 1.9953 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (binding) 7.0795 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.4921 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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