Detailed information for compound 1877486

Basic information

Technical information
  • TDR Targets ID: 1877486
  • Name: N-[(3-nitrophenyl)methylideneamino]benzo[e][1 ]benzoxole-2-carboxamide
  • MW: 359.335 | Formula: C20H13N3O4
  • H donors: 1 H acceptors: 3 LogP: 4.65 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1oc2c(c1)c1ccccc1cc2)N/N=C/c1cccc(c1)[N+](=O)[O-]
  • InChi: 1S/C20H13N3O4/c24-20(22-21-12-13-4-3-6-15(10-13)23(25)26)19-11-17-16-7-2-1-5-14(16)8-9-18(17)27-19/h1-12H,(H,22,24)/b21-12+
  • InChiKey: HSDFDMSYAUCFSY-CIAFOILYSA-N  


Substructure search Similarity search

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Synonyms

  • N-[(3-nitrophenyl)methyleneamino]benzo[e]benzofuran-2-carboxamide
  • N-[(3-nitrophenyl)methyleneamino]-2-benzo[e]benzofurancarboxamide
  • N-[(3-nitrobenzylidene)amino]benzo[e]benzofuran-2-carboxamide
  • AN-988/40679788
  • N'-{3-nitrobenzylidene}naphtho[2,1-b]furan-2-carbohydrazide
  • SMR000161103
  • MLS000545131

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens acid phosphatase 1, soluble Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01090 protein phosphatase [EC3.1.3.16], putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans 3' exon of potential Low molecular weight phosphoTyrosine Phosphatase gene Get druggable targets OG5_127571 All targets in OG5_127571
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani dullard-like phosphatase domain containing protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein Get druggable targets OG5_127571 All targets in OG5_127571
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva nuclear LIM interactor-interacting factor 1, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans C terminus of potential Low molecular weight phosphoTyrosine Phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) Get druggable targets OG5_127571 All targets in OG5_127571
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Toxoplasma gondii Dullard family phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Babesia bovis Dullard-like phosphatase domain containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus CTD small phosphatase protein like Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA Get druggable targets OG5_127571 All targets in OG5_127571
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense TFIIF-stimulated CTD phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Nuclear LIM interactor-interacting factor 1 Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) phosphotyrosine protein phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum CTD small phosphatase-like protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Trypanosoma brucei TFIIF-stimulated CTD phosphatase, putative CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 260 aa 263 aa 27.0 %
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Mycobacterium tuberculosis Probable acyl-[acyl-carrier protein] desaturase DesA1 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase) (protein Des) acid phosphatase 1, soluble 112 aa 107 aa 24.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi cathepsin L-like precursor 0.0014 0.006 0.0098
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.007 0.074 0.2748
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0373 0.2902
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0024 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0211 0.0723
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0551 0.4372
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0356 0.2762
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.2634 1
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0328 0.3872 0.3872
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0565 0.0565
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0551 0.1375
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0423 0.0423
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0015 0.0077 0.0212
Leishmania major hypothetical protein, conserved 0.0015 0.0077 0.0278
Brugia malayi Cathepsin L-like precursor 0.0014 0.006 0.0098
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.2634 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0514 0.0514
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1337 0.5034
Leishmania major cathepsin L-like protease 0.002 0.0141 0.0812
Echinococcus granulosus acylamino acid releasing enzyme 0.0026 0.0211 0.0211
Schistosoma mansoni cpg binding protein 0.0037 0.034 0.034
Loa Loa (eye worm) beta-lactamase 0.0043 0.0423 0.1032
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0141 0.0299
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0316 0.0755
Leishmania major cysteine peptidase A (CPA) 0.002 0.0141 0.0812
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0141 0.6295
Onchocerca volvulus Prolyl endopeptidase homolog 0.0026 0.0211 0.0396
Echinococcus granulosus expressed conserved protein 0.0112 0.125 0.125
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0026 0.0211 0.1401
Echinococcus granulosus cpg binding protein 0.0037 0.034 0.034
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0423 0.0996
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0026 0.0211 0.156
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0178 0.1291
Echinococcus multilocularis expressed protein 0.004 0.0385 0.0385
Leishmania major DNA polymerase eta, putative 0.0038 0.0356 0.2626
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0077 0.0212
Toxoplasma gondii cathepsin CPL 0.002 0.0141 0.0812
Loa Loa (eye worm) hypothetical protein 0.0054 0.0551 0.1366
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0423 0.3312
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0178 0.1127
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0026 0.0211 0.0723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0141 0.0455
Leishmania major DNA polymerase kappa, putative 0.0023 0.0178 0.1127
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0178 0.1291
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0026 0.0211 0.0723
Mycobacterium tuberculosis Probable peptidase 0.0026 0.0211 0.0106
Loa Loa (eye worm) hypothetical protein 0.0015 0.0077 0.0134
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0226 0.2634 0.6783
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0373 0.2768
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.083 0.6673
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.083 0.6673
Mycobacterium tuberculosis Conserved protein 0.0043 0.0423 0.0793
Echinococcus granulosus Dipeptidyl peptidase 9 0.011 0.1232 0.1232
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0178 0.0178
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.007 0.074 0.5931
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0178 0.1291
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0026 0.0211 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0141 0.0455
Onchocerca volvulus 0.002 0.0141 0.0213
Echinococcus granulosus prolyl endopeptidase 0.0026 0.0211 0.0211
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0514 0.127
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0141 0.0299
Loa Loa (eye worm) hypothetical protein 0.0043 0.0423 0.1032
Toxoplasma gondii hypothetical protein 0.0026 0.0211 0.1401
Trypanosoma brucei unspecified product 0.0016 0.009 0.0567
Plasmodium vivax vivapain-2 0.002 0.0141 0.2965
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0141 0.0455
Loa Loa (eye worm) hypothetical protein 0.0043 0.0423 0.1032
Schistosoma mansoni hypothetical protein 0.0205 0.2377 0.2377
Brugia malayi Cathepsin L-like precursor 0.002 0.0141 0.0309
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0211 0.156
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0565 0.0565
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0328 0.3872 0.3872
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.011 0.1232 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0178 0.1291
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0178 0.0178
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.011 0.1232 0.1232
Trichomonas vaginalis dullard protein, putative 0.0015 0.0077 0.0212
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0211 0.4711
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0026 0.0211 0.156
Brugia malayi beta-lactamase family protein 0.0043 0.0423 0.1041
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.011 0.1232 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0026 0.0026
Giardia lamblia Alanyl dipeptidyl peptidase 0.0026 0.0211 0.0522
Echinococcus multilocularis cathepsin L 0.001 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0043 0.0423 0.1032
Brugia malayi CXXC zinc finger family protein 0.0035 0.0316 0.0764
Loa Loa (eye worm) hypothetical protein 0.0043 0.0423 0.1032
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.007 0.074 0.2748
Loa Loa (eye worm) hypothetical protein 0.0014 0.006 0.0088
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0423 0.0793
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0178 0.0178
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0026 0.0211 0.1401
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0178 0.1291
Loa Loa (eye worm) hypothetical protein 0.0014 0.006 0.0088
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0423 0.0793
Trypanosoma brucei prolyl endopeptidase 0.0026 0.0211 0.156
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0141 0.0141
Schistosoma mansoni hypothetical protein 0.0049 0.0492 0.0492
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0141 0.0141
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0178 0.0178
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.2634 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0423 0.1534
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0178 0.1291
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0514 0.1885
Leishmania major cathepsin L-like protease 0.002 0.0141 0.0812
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0141 0.6295
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.011 0.1232 1
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0156 0.179 0.5224
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0328 0.3872 1
Toxoplasma gondii prolyl endopeptidase 0.0026 0.0211 0.1401
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.083 0.6673
Loa Loa (eye worm) hypothetical protein 0.0043 0.0423 0.1032
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0565 0.0565
Schistosoma mansoni hypothetical protein 0.0049 0.0492 0.0492
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0423 0.0793
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0565 0.0565
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0026 0.0026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0141 0.0455
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.083 0.6673
Trypanosoma brucei prolyl oligopeptidase, putative 0.0026 0.0211 0.156
Echinococcus multilocularis 0.0015 0.0077 0.0077
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0551 0.4372
Loa Loa (eye worm) hypothetical protein 0.0014 0.006 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.006 0.0145
Loa Loa (eye worm) cysteine protease 0.002 0.0141 0.0299
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0565 0.1412
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0026 0.0211 0.0106
Trypanosoma brucei oligopeptidase b 0.0026 0.0211 0.156
Brugia malayi Cathepsin L-like precursor 0.002 0.0141 0.0309
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0077 0.0212
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0026 0.0211 0.0211
Echinococcus multilocularis dna polymerase eta 0.0054 0.0551 0.0551
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.006 0.0145
Onchocerca volvulus 0.002 0.0141 0.0213
Onchocerca volvulus 0.002 0.0141 0.0213
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.083 0.6673
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1359 0.1359
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0141 0.0455
Loa Loa (eye worm) prolyl oligopeptidase 0.0026 0.0211 0.0481
Schistosoma mansoni hypothetical protein 0.0494 0.5885 0.5885
Onchocerca volvulus Cathepsin F homolog 0.002 0.0141 0.0213
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0015 0.0077 0.1382
Echinococcus granulosus cathepsin l1 0.0014 0.006 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0141 0.0455
Echinococcus multilocularis prolyl endopeptidase 0.0026 0.0211 0.0211
Brugia malayi prolyl oligopeptidase family protein 0.011 0.1232 0.3144
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1337 0.3416
Loa Loa (eye worm) fibroinase 0.002 0.0141 0.0299
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.006 0.006
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0141 0.0141
Brugia malayi CHE-14 protein 0.0051 0.0514 0.1279
Giardia lamblia DINP protein human, muc B family 0.0023 0.0178 0.0395
Echinococcus multilocularis Dipeptidyl peptidase 9 0.011 0.1232 0.1232
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0423 0.0423
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.2634 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0141 0.0141
Plasmodium falciparum peptidase, putative 0.0026 0.0211 1
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.083 0.6673
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.083 0.6673
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0178 0.1291
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0015 0.0077 0.0458
Schistosoma mansoni hypothetical protein 0.0049 0.0492 0.0492
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0226 0.2634 1
Trichomonas vaginalis esterase, putative 0.0043 0.0423 0.1534
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0015 0.0077 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0141 0.0455
Leishmania major cathepsin L-like protease 0.0077 0.083 0.661
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0141 0.0455
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0385 0.0942
Loa Loa (eye worm) hypothetical protein 0.002 0.0141 0.0299
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0514 0.0514
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0423 1
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0423 0.0996
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Echinococcus granulosus CTD small phosphatase protein like 0.0015 0.0077 0.0077
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.011 0.1232 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0026 0.0211 0.0723
Entamoeba histolytica prolyl oligopeptidase family protein 0.0026 0.0211 0.0723
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.074 0.5931
Leishmania major cathepsin L-like protease 0.0077 0.083 0.661
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0141 0.0455
Onchocerca volvulus Cathepsin L homolog 0.002 0.0141 0.0213
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0178 0.1291
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0226 0.2634 1
Trypanosoma cruzi oligopeptidase b 0.0026 0.0211 0.156
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0373 0.2768
Onchocerca volvulus 0.002 0.0141 0.0213
Schistosoma mansoni cpg binding protein 0.0037 0.034 0.034
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0015 0.0077 0.1382
Echinococcus multilocularis acylamino acid releasing enzyme 0.0026 0.0211 0.0211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0141 0.0455
Brugia malayi prolyl oligopeptidase family protein 0.0026 0.0211 0.0491
Schistosoma mansoni DNA polymerase eta 0.0054 0.0551 0.0551
Leishmania major cathepsin L-like protease 0.002 0.0141 0.0812
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.009 0.0567
Brugia malayi prolyl oligopeptidase family protein 0.0328 0.3872 1
Echinococcus granulosus cysteine protease 0.001 0.0022 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0423 0.3312
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1956 0.1956
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0178 0.1291
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.011 0.1232 1
Entamoeba histolytica cysteine protease, putative 0.002 0.0141 0.0455
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0015 0.0077 0.0144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.083 0.6673
Onchocerca volvulus 0.0043 0.0423 0.0952
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0178 0.1291
Brugia malayi hypothetical protein 0.0084 0.0917 0.2326
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0565 0.0565
Onchocerca volvulus 0.0043 0.0423 0.0952
Giardia lamblia Alanyl dipeptidyl peptidase 0.0026 0.0211 0.0522
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0423 0.1041
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.0077 0.0077
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0178 0.1291
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0026 0.0211 0.0211
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0026 0.0211 0.1401
Trichomonas vaginalis dullard protein, putative 0.0015 0.0077 0.0212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.083 0.6673
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0141 0.0455
Leishmania major hypothetical protein, conserved 0.0043 0.0423 0.3186
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0178 0.1291
Brugia malayi prolyl oligopeptidase family protein 0.0026 0.0211 0.0491
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0026 0.0211 0.156
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0178 0.0406
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0423 0.0793
Onchocerca volvulus 0.0226 0.2634 0.6754
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0692 0.5454
Leishmania major cathepsin L-like protease 0.0077 0.083 0.661
Echinococcus granulosus cathepsin L 0.001 0.0022 0.0022
Onchocerca volvulus 0.0043 0.0423 0.0952
Mycobacterium tuberculosis Conserved protein 0.0043 0.0423 0.0793
Echinococcus multilocularis cysteine protease 0.002 0.0141 0.0141
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0178 0.1291
Echinococcus granulosus geminin 0.0205 0.2377 0.2377
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0788 0.0788
Onchocerca volvulus Cathepsin L homolog 0.002 0.0141 0.0213
Echinococcus multilocularis geminin 0.0205 0.2377 0.2377
Onchocerca volvulus 0.002 0.0141 0.0213
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0226 0.2634 0.6786
Loa Loa (eye worm) hypothetical protein 0.0051 0.0514 0.127
Echinococcus multilocularis cysteine protease 0.002 0.0141 0.0141
Schistosoma mansoni hypothetical protein 0.0049 0.0492 0.0492
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0026 0.0211 0.156
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.083 0.6673
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0423 0.0793
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0373 0.1345
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.2634 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0211 0.0481
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0015 0.0077 0.0278
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.083 0.6673
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0178 0.0598
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.006 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0141 0.0455
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0226 0.2634 1
Schistosoma mansoni patched 1 0.0051 0.0514 0.0514
Echinococcus granulosus cathepsin l1 0.002 0.0141 0.0141
Echinococcus multilocularis expressed conserved protein 0.0112 0.125 0.125
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.009 0.0567
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0141 0.0141
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0077 0.0212
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0178 0.0598
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0141 0.0455
Mycobacterium leprae Probable lipase LipE 0.0043 0.0423 1
Echinococcus multilocularis cpg binding protein 0.0037 0.034 0.034
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0141 0.0455
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.006 0.0145
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0141 0.0141
Brugia malayi Cathepsin L-like precursor 0.002 0.0141 0.0309
Brugia malayi prolyl oligopeptidase family protein 0.0026 0.0211 0.0491
Trichomonas vaginalis dullard protein, putative 0.0015 0.0077 0.0212
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.0077 0.0077
Loa Loa (eye worm) prolyl oligopeptidase 0.0328 0.3872 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0026 0.0211 0.0211
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5885 0.5885
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0328 0.3872 0.3872
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0423 0.1534
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0141 0.0455
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.009 0.0567
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0423 0.1534
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0423 0.1534
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0141 0.0455
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0077 0.0458
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.083 0.6673
Onchocerca volvulus 0.002 0.0141 0.0213
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0423 0.0793
Loa Loa (eye worm) hypothetical protein 0.0119 0.1337 0.341
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.083 0.6673
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0423 0.3312
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.083 0.6673
Echinococcus granulosus dna polymerase eta 0.0054 0.0551 0.0551
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0012 0.0044 0.5
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0385 0.0933
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0015 0.0077 0.0077
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.0044 0.0185
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.0044 0.0185
Plasmodium vivax vivapain-2 0.002 0.0141 0.2965
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0423 0.0793
Loa Loa (eye worm) ctsf protein 0.002 0.0141 0.0299
Brugia malayi Cathepsin L-like precursor 0.0014 0.006 0.0098
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0373 0.2902
Echinococcus granulosus expressed protein 0.004 0.0385 0.0385
Schistosoma mansoni hypothetical protein 0.0205 0.2377 0.2377
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0077 0.0212
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0141 0.0455
Leishmania major DNA polymerase eta, putative 0.0054 0.0551 0.4266
Entamoeba histolytica prolyl oligopeptidase family protein 0.0026 0.0211 0.0723
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0141 0.0455
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0423 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0423 0.0423
Loa Loa (eye worm) hypothetical protein 0.0026 0.0211 0.0481
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0178 0.1291
Toxoplasma gondii ABC1 family protein 0.0043 0.0423 0.3186
Echinococcus granulosus dna polymerase kappa 0.0023 0.0178 0.0178
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0356 0.2626
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0141 0.0455
Loa Loa (eye worm) hypothetical protein 0.0062 0.0653 0.1632
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0141 0.0455
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5885 0.5885
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1956 0.1956
Schistosoma mansoni hypothetical protein 0.0015 0.0075 0.0075
Schistosoma mansoni rotamase 0.004 0.0385 0.0385
Trichomonas vaginalis rotamase, putative 0.004 0.0385 0.1389
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0022 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0211 0.156
Brugia malayi Cathepsin L-like precursor 0.002 0.0141 0.0309
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0226 0.2634 1
Brugia malayi beta-lactamase 0.0043 0.0423 0.1041
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0026 0.0211 0.0723
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0141 0.6295
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0178 0.0178
Leishmania major oligopeptidase b 0.0026 0.0211 0.1401
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0015 0.0077 0.2933
Trypanosoma cruzi oligopeptidase b 0.0026 0.0211 0.156
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0141 0.0455
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0141 0.0455
Schistosoma mansoni cpg binding protein 0.0035 0.0316 0.0316
Onchocerca volvulus 0.0035 0.0316 0.0673
Brugia malayi beta-lactamase family protein 0.0043 0.0423 0.1041
Entamoeba histolytica prolyl oligopeptidase family protein 0.0026 0.0211 0.0723
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0514 0.0514
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0385 0.1389
Loa Loa (eye worm) hypothetical protein 0.0026 0.0211 0.0481
Leishmania major cathepsin L-like protease 0.002 0.0141 0.0812
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0178 0.1291
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0178 0.1291
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0022 0.0022
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0178 0.0598
Leishmania major cathepsin L-like protease 0.002 0.0141 0.0812
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.063 0.5022
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0373 0.2902
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0423 0.0423
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0141 0.0455
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0141 0.0455
Mycobacterium ulcerans hypothetical protein 0.0043 0.0423 0.0996
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0178 0.1291
Echinococcus multilocularis protein dispatched 1 0.0058 0.0602 0.0602
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.2634 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0423 0.1534
Brugia malayi Cathepsin L-like precursor 0.002 0.0141 0.0309
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0423 0.1032
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0026 0.0211 0.0211
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1337 0.1337
Echinococcus multilocularis protein patched 0.0051 0.0514 0.0514
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0749 0.6004
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.074 0.5931
Trypanosoma brucei unspecified product 0.0016 0.009 0.0567
Leishmania major hypothetical protein, conserved 0.007 0.074 0.5854
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.083 0.6673
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1337 0.1337
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.3264 1
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0141 0.0982
Loa Loa (eye worm) hypothetical protein 0.0043 0.0423 0.1032
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0022 0.0022
Onchocerca volvulus 0.002 0.0141 0.0213
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0141 0.0141
Trichomonas vaginalis rotamase, putative 0.0039 0.0373 0.1345
Trypanosoma brucei unspecified product 0.0023 0.0178 0.1291
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0565 0.0565
Mycobacterium tuberculosis Conserved protein 0.0043 0.0423 0.0793
Brugia malayi Cathepsin L-like precursor 0.002 0.0141 0.0309
Loa Loa (eye worm) hypothetical protein 0.0084 0.0917 0.2318
Mycobacterium ulcerans lipase LipD 0.0043 0.0423 0.0996
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0178 0.0396
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0141 0.0455
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.0211 0.0723
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0128
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0022 0.0022
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0012 0.0044 0.0185
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0141 0.0455
Mycobacterium ulcerans beta-lactamase 0.0043 0.0423 0.0996
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0141 0.0309
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0141 0.0141
Trypanosoma cruzi prolyl endopeptidase 0.0026 0.0211 0.156
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0141 0.0455
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0565 0.1403
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.011 0.1232 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0565 0.0565

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 0.354813389 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
IC50 (functional) = 3.913 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493091, AID493120] ChEMBL. No reference
IC50 (functional) 4.06 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 80 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, in an orthogonal absorbance-based assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0738 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.4654 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 2.2387 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.5686 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 47.4436 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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