Detailed information for compound 1879149

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 459.451 | Formula: C25H21N3O6
  • H donors: 3 H acceptors: 3 LogP: 3.73 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(/C=N/NC(=O)/C(=C\c2ccc3c(c2)OCO3)/NC(=O)c2ccccc2)ccc1O
  • InChi: 1S/C25H21N3O6/c1-32-22-13-17(7-9-20(22)29)14-26-28-25(31)19(27-24(30)18-5-3-2-4-6-18)11-16-8-10-21-23(12-16)34-15-33-21/h2-14,29H,15H2,1H3,(H,27,30)(H,28,31)/b19-11+,26-14+
  • InChiKey: ABURDUMLEUCKOY-LABBUYSVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0032 0.1143 0.1143
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0194 0.0328
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0626 0.0626
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0112 0.5912 0.5912
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0626 0.1058
Loa Loa (eye worm) hypothetical protein 0.0054 0.2461 0.2461
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0073 0.3606 0.6099
Trypanosoma brucei unspecified product 0.0016 0.0194 0.0328
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0035 0.1303 0.2205
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0631 0.1068
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0626 0.1058
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0073 0.3606 0.6099
Brugia malayi Cytochrome P450 family protein 0.0023 0.0631 0.0631
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0112 0.5912 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0173 0.0173
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0442 0.2867
Brugia malayi Cytochrome P450 family protein 0.0059 0.275 0.275
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0112 0.5912 0.6543
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.2827 0.2827
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0112 0.5912 0.6543
Leishmania major DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0112 0.5912 0.5912
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.275 0.275
Echinococcus granulosus dna polymerase eta 0.0054 0.2461 0.2461
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0631 0.0631
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0626 0.0692
Echinococcus multilocularis lamin 0.0033 0.1178 0.1178
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0112 0.5912 1
Schistosoma mansoni hypothetical protein 0.0019 0.0372 0.0411
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0112 0.5912 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0035 0.1303 0.2205
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0626 0.1058
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0039 0.1541 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.361 0.361
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.8307 0.8307
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0112 0.5912 1
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0112 0.5912 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Brugia malayi intermediate filament protein 0.0033 0.1178 0.1178
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.1502 0.2541
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0943 0.0601
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0626 0.406
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.006 0.2827 0.2827
Loa Loa (eye worm) hypothetical protein 0.0029 0.0943 0.0943
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0372 0.0372
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0194 0.0328
Loa Loa (eye worm) hypothetical protein 0.0021 0.0512 0.0512
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0512 0.332
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0112 0.5912 0.6543
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0194 0.0328
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0512 0.0865
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0112 0.5912 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.9036 0.9036
Trypanosoma brucei unspecified product 0.0016 0.0194 0.0328
Loa Loa (eye worm) hypothetical protein 0.018 1 1
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0112 0.5912 1
Loa Loa (eye worm) hypothetical protein 0.018 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0943 0.6122
Leishmania major DNA polymerase eta, putative 0.0054 0.2461 0.4163
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0943 0.1596
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0943 0.1596
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0372 0.0372
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.8307 0.8307
Loa Loa (eye worm) hypothetical protein 0.0029 0.0943 0.0943
Loa Loa (eye worm) hypothetical protein 0.0021 0.0512 0.0512
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0631 0.1068
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0073 0.361 0.361
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0943 0.6122
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0943 0.1596
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0372 0.0372
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Onchocerca volvulus 0.0033 0.1178 1
Echinococcus granulosus lamin dm0 0.0033 0.1178 0.1178
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0943 0.0601
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.2827 0.2827
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0276 0.0276
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0372 0.0372
Schistosoma mansoni intermediate filament proteins 0.0033 0.1178 0.1304
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.1178 0.1178
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0112 0.5912 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0276 0.0276
Schistosoma mansoni lamin 0.0033 0.1178 0.1304
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0112 0.5912 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0372 0.0372
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0626 0.1058
Echinococcus granulosus dna polymerase kappa 0.0023 0.0626 0.0626
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0943 0.0943
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0073 0.361 0.5644
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0137
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0112 0.5912 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.1178 0.1178
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0943 0.0601
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0112 0.5912 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0512 0.0512
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Schistosoma mansoni thyroid hormone receptor 0.0164 0.9036 1
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0039 0.1537 0.1537
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0372 0.0372
Leishmania major DNA polymerase eta, putative 0.0038 0.1502 0.2541
Echinococcus multilocularis muscleblind protein 0.018 1 1
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.2461 0.4163
Brugia malayi Cytochrome P450 family protein 0.0023 0.0631 0.0631
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0943 0.1596
Schistosoma mansoni hypothetical protein 0.0019 0.0372 0.0411
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0035 0.1303 0.1303
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0626 0.406
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0073 0.361 0.361
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0626 0.1058
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.7838 0.7838
Echinococcus multilocularis muscleblind protein 1 0.018 1 1
Schistosoma mansoni hypothetical protein 0.0019 0.0372 0.0411
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0173 0.0173
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0112 0.5912 0.5912
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0112 0.5912 1
Schistosoma mansoni hypothetical protein 0.0152 0.8307 0.9194
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0112 0.5912 0.5
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0112 0.5912 0.5912
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0073 0.3606 0.6099
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0073 0.361 0.361
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0137
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0073 0.361 0.5644
Echinococcus multilocularis lamin dm0 0.0033 0.1178 0.1178
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0943 0.1596
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0631 0.1068
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.1502 0.2541
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.1178 0.1178
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0035 0.1303 0.2205
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0073 0.3606 0.6099
Trypanosoma brucei unspecified product 0.0023 0.0626 0.1058
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0631 0.0631
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Echinococcus multilocularis GPCR, family 2 0.0019 0.0372 0.0372
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0035 0.1303 0.2205
Onchocerca volvulus 0.0033 0.1178 1
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0372 0.0372
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0943 0.0943
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0626 0.0626
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0112 0.5912 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0943 0.1596
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1691 0.1691
Echinococcus granulosus muscleblind protein 0.018 1 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.1178 0.1178
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.2461 0.2461
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0112 0.5912 0.6543
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.2461 0.4163
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0943 0.1596
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0442 0.2867
Schistosoma mansoni hypothetical protein 0.0019 0.0372 0.0411
Schistosoma mansoni DNA polymerase eta 0.0054 0.2461 0.2724
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.2827 0.2827
Echinococcus multilocularis dna polymerase eta 0.0054 0.2461 0.2461
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0943 0.0943
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0077 0.3843 0.3843
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Brugia malayi MH2 domain containing protein 0.0144 0.7838 0.7838
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0626 0.0692
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0631 0.1068
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0039 0.1537 0.1725
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0631 0.0631
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.7838 0.7838
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0626 0.1058
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0943 0.1596
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0112 0.5912 0.5912
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0035 0.1303 0.2205
Mycobacterium ulcerans hypothetical protein 0.0029 0.0943 0.1596
Echinococcus granulosus GPCR family 2 0.0019 0.0372 0.0372
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0112 0.5912 1
Schistosoma mansoni hypothetical protein 0.0041 0.1691 0.1871
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0039 0.1541 1
Schistosoma mansoni thyroid hormone receptor 0.0164 0.9036 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Echinococcus multilocularis musashi 0.0033 0.1178 0.1178
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0112 0.5912 1
Leishmania major cytochrome p450-like protein 0.0023 0.0631 0.1068
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0073 0.3606 0.5638
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0077 0.3843 0.3843
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0442 0.2867
Loa Loa (eye worm) hypothetical protein 0.0029 0.0943 0.0943
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0626 0.1058
Loa Loa (eye worm) hypothetical protein 0.0021 0.0512 0.0512
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0112 0.5912 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0512 0.0512
Schistosoma mansoni lamin 0.0033 0.1178 0.1304
Loa Loa (eye worm) hypothetical protein 0.0019 0.0372 0.0372
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0626 0.0626
Echinococcus granulosus lamin 0.0033 0.1178 0.1178
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0442 0.2867
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1691 0.1691
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0626 0.0626
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0626 0.0626
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0073 0.361 0.361
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0943 0.1596
Echinococcus granulosus intermediate filament protein 0.0033 0.1178 0.1178
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0943 0.6122
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0943 0.6122
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0943 0.1596

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 79.4 uM PubChem BioAssay. Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.3548 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.4716 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.3582 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.