Detailed information for compound 1999324

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 428.486 | Formula: C24H24N6O2
  • H donors: 1 H acceptors: 3 LogP: 2.52 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1n(C)cnc2c1c(NCc1ccncc1)nc(c2)c1ccc(cc1)N1CCOCC1
  • InChi: 1S/C24H24N6O2/c1-29-16-27-21-14-20(18-2-4-19(5-3-18)30-10-12-32-13-11-30)28-23(22(21)24(29)31)26-15-17-6-8-25-9-7-17/h2-9,14,16H,10-13,15H2,1H3,(H,26,28)
  • InChiKey: JLMQWYWLIRROLL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens spleen tyrosine kinase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tyrosine protein kinase shark Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma japonicum ko:K05855 spleen tyrosine kinase, putative Get druggable targets OG5_131855 All targets in OG5_131855
Echinococcus multilocularis tyrosine protein kinase shark Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma japonicum ko:K08253 non-specific protein-tyrosine kinase [EC2.7.10.2], putative Get druggable targets OG5_131855 All targets in OG5_131855
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0039 0.0127 0.6288
Brugia malayi glutathione reductase 0.0053 0.0201 0.1701
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0022 0.0022
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0145 0.0678 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0552
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0043 0.0149 0.0183
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0 0.0002
Schistosoma mansoni cpg binding protein 0.0113 0.0509 0.0666
Mycobacterium ulcerans isocitrate lyase Icl 0.1949 1 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0018 0.0848
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0145 0.0678 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0022 0.0022
Plasmodium falciparum DNA gyrase subunit B 0.0014 0.0000094672 0.0001
Chlamydia trachomatis DNA gyrase subunit B 0.0023 0.0048 0.0702
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0067 0.0075
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0037 0.0116 0.0152
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0118
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0022 0.0037
Schistosoma mansoni ap endonuclease 0.0018 0.0018 0.0024
Trypanosoma brucei trypanothione reductase 0.0053 0.0201 1
Schistosoma mansoni hypothetical protein 0.0046 0.0165 0.0216
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0022 0.0029
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0061 0.0068
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0015 0.0219
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0145 0.0678 0.0678
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0021 0.0016
Loa Loa (eye worm) CXXC zinc finger family protein 0.0105 0.0468 0.4207
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0022 0.1049
Trypanosoma brucei DNA topoisomerase ii 0.0034 0.0102 0.5033
Loa Loa (eye worm) intermediate filament protein 0.0026 0.006 0.0441
Leishmania major hypothetical protein, conserved 0.0028 0.0072 0.3557
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0035 0.011 0.0851
Schistosoma mansoni phd/f-box containing protein 0.0028 0.0072 0.0095
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0035 0.011 0.5425
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0072 0.0552
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0028 0.0072 0.3557
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0018 0.0264
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0034 0.0102 0.5033
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0018 0.0018
Brugia malayi jmjC domain containing protein 0.0028 0.0072 0.0504
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0552
Echinococcus granulosus dnaJ subfamily B 0.1492 0.764 1
Echinococcus granulosus peptidase Clp S14 family 0.0095 0.0419 0.0537
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.0683 0.6191
Schistosoma mansoni lamin 0.0026 0.006 0.0079
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0035 0.011 0.0144
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0022 0.0022
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0135 0.0623 0.0623
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.0136 0.0166
Brugia malayi jmjC domain containing protein 0.0028 0.0072 0.0504
Leishmania major mitochondrial DNA topoisomerase II 0.0034 0.0102 0.5033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0021 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.005 0.2401
Echinococcus granulosus zinc finger protein 0.0024 0.0053 0.0056
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0095 0.0419 0.0419
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0031 0.0088 0.0593
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0022 0.1049
Loa Loa (eye worm) hypothetical protein 0.0073 0.0307 0.2714
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0018 0.0848
Brugia malayi TAR-binding protein 0.0131 0.0606 0.5453
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0022 0.1049
Brugia malayi RNA binding protein 0.0131 0.0606 0.5453
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0095 0.0987
Trichomonas vaginalis helicase, putative 0.0024 0.005 0.2401
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0173 0.082 0.1062
Plasmodium falciparum thioredoxin reductase 0.0053 0.0201 0.2972
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0043 0.0149 0.1219
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.005 0.2401
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0145 0.0678 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.0136 0.0166
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0095 0.0987
Schistosoma mansoni tyrosine kinase 0.0258 0.1261 0.1651
Brugia malayi jmjC domain containing protein 0.0113 0.0512 0.4585
Echinococcus granulosus tar DNA binding protein 0.0131 0.0606 0.0782
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0018 0.0264
Schistosoma mansoni single-minded 0.0047 0.0171 0.0224
Trichomonas vaginalis DNA topoisomerase II, putative 0.0043 0.0149 1
Echinococcus granulosus lysine specific demethylase 5A 0.0113 0.0512 0.0659
Echinococcus multilocularis lysine specific demethylase 5A 0.0105 0.0472 0.0606
Echinococcus granulosus jumonji domain containing 1A 0.0028 0.0072 0.0082
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.005 0.2401
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0035 0.011 0.0131
Echinococcus granulosus mixed lineage leukemia protein mll 0.0026 0.0061 0.0068
Treponema pallidum NADH oxidase 0.0018 0.0022 0.0323
Toxoplasma gondii DNA topoisomerase 2, putative 0.0043 0.0149 0.1549
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0031 0.0088 0.0593
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0022 0.0016
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0022 0.0325
Echinococcus multilocularis peptidase Clp (S14 family) 0.0095 0.0419 0.0537
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0022 0.1049
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.0136 0.0166
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0022 0.1049
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0022 0.0323
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0118
Schistosoma mansoni jumonji domain containing protein 0.0151 0.0707 0.0925
Onchocerca volvulus Huntingtin homolog 0.0117 0.0533 1
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0022 0.0307
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0035 0.011 0.7544
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.1949 1 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0145 0.0678 0.0876
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0022 0.1049
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0018 0.0264
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.011 0.5425
Echinococcus multilocularis ubiquitin specific protease 41 0.0035 0.011 0.0131
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0035 0.011 0.0131
Echinococcus granulosus single minded 2 0.0035 0.0108 0.0129
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.011 0.5425
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0606 0.0793
Leishmania major trypanothione reductase 0.0053 0.0201 1
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.005 0.2401
Brugia malayi Bromodomain containing protein 0.0035 0.0107 0.0823
Schistosoma mansoni jumonji/arid domain-containing protein 0.0113 0.0512 0.0671
Plasmodium falciparum glutathione reductase 0.0053 0.0201 0.2972
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0067 0.0075
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0022 0.1049
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0018 0.0011
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0145 0.0678 0.0876
Onchocerca volvulus Alhambra homolog 0.0033 0.0095 0.0741
Loa Loa (eye worm) hypothetical protein 0.0036 0.0113 0.0926
Echinococcus multilocularis lamin dm0 0.0026 0.006 0.0066
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0043 0.0149 0.1219
Loa Loa (eye worm) PHD-finger family protein 0.0019 0.0027 0.0133
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0021 0.0016
Loa Loa (eye worm) hypothetical protein 0.0066 0.027 0.2372
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0121 0.0553 0.0553
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0121 0.0553 0.0553
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0095 0.0112
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0095 0.0764
Plasmodium falciparum thioredoxin reductase 0.0018 0.0022 0.0325
Loa Loa (eye worm) TAR-binding protein 0.0131 0.0606 0.5477
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0026 0.0061 0.0068
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.006 0.0441
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.005 0.2401
Onchocerca volvulus 0.0035 0.0108 0.1007
Echinococcus multilocularis musashi 0.0026 0.006 0.0066
Echinococcus granulosus survival motor neuron protein 1 0.0226 0.1096 0.1424
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0017 0.0015 0.022
Mycobacterium tuberculosis Probable oxidoreductase 0.0135 0.0623 0.0623
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0145 0.0678 1
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0606 0.0793
Schistosoma mansoni lamin 0.0026 0.006 0.0079
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0035 0.011 0.0131
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.005 0.0186 0.2737
Loa Loa (eye worm) hypothetical protein 0.0035 0.011 0.0898
Loa Loa (eye worm) hypothetical protein 0.0159 0.0747 0.6777
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.005 0.2401
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0018 0.0018
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0222 0.1076 0.1408
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0161 0.0199
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0121 0.0553 0.0553
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0606 0.0793
Schistosoma mansoni hypothetical protein 0.1492 0.764 1
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.005 0.2401
Mycobacterium tuberculosis Probable reductase 0.0121 0.0553 0.0553
Schistosoma mansoni hypothetical protein 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0226 0.1096 1
Brugia malayi Bromodomain containing protein 0.0076 0.0321 0.2811
Schistosoma mansoni DNA topoisomerase II 0.0043 0.0149 0.0196
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.005 0.2401
Toxoplasma gondii histone lysine methyltransferase SET1 0.0201 0.0964 1
Entamoeba histolytica DNA topoisomerase II, putative 0.0043 0.0149 1
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0201 0.1744
Echinococcus granulosus cpg binding protein 0.0113 0.0509 0.0654
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.011 0.698
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.005 0.2401
Echinococcus granulosus lamin dm0 0.0026 0.006 0.0066
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0121 0.0553 0.0553
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0035 0.011 0.7343
Brugia malayi PHD-finger family protein 0.0029 0.0078 0.0561
Loa Loa (eye worm) hypothetical protein 0.0038 0.0124 0.1031
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0043 0.0149 0.0183
Mycobacterium tuberculosis Probable dehydrogenase 0.0121 0.0553 0.0553
Brugia malayi jmjC domain containing protein 0.0028 0.0072 0.0504
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0247 0.0311
Schistosoma mansoni protein phosphatase 2C 0.0028 0.0072 0.0095
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0606 0.0793
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0028 0.0072 0.0749
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0035 0.011 0.698
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0031 0.0088 0.0593
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0022 0.1049
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.011 0.5425
Echinococcus granulosus tyrosine protein kinase shark 0.0264 0.1293 0.1682
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0034 0.0101 0.012
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0201 1
Echinococcus granulosus intermediate filament protein 0.0026 0.006 0.0066
Giardia lamblia PHD finger protein 15 0.0033 0.0095 0.6353
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0022 0.0307
Onchocerca volvulus 0.0105 0.0468 0.8638
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0022 0.1049
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0095 0.0419 0.0419
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0201 0.0252
Toxoplasma gondii hypothetical protein 0.005 0.0186 0.1924
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0275 0.2418
Echinococcus multilocularis jumonji domain containing 1A 0.0028 0.0072 0.0082
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.005 0.2401
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0009 0.0012
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0018 0.0848
Brugia malayi hypoxia-induced factor 1 0.0146 0.0683 0.6171
Echinococcus multilocularis tyrosine protein kinase shark 0.0264 0.1293 0.1682
Loa Loa (eye worm) hypothetical protein 0.0029 0.0076 0.0588
Loa Loa (eye worm) hypothetical protein 0.0025 0.0058 0.0418
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0108 0.0833
Brugia malayi PHD-finger family protein 0.0018 0.0022 0.0037
Echinococcus multilocularis phd:f box containing protein 0.0028 0.0072 0.0082
Loa Loa (eye worm) glutathione reductase 0.0053 0.0201 0.1744
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0072 0.3557
Echinococcus granulosus JmjC domain containing protein 4 0.0028 0.0072 0.0082
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0135 0.0623 0.0446
Echinococcus multilocularis JmjC domain containing protein 4 0.0028 0.0072 0.0082
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0108 0.0129
Schistosoma mansoni cpg binding protein 0.0113 0.0509 0.0666
Brugia malayi Probable DNA topoisomerase II 0.0043 0.0149 0.1219
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.005 0.2401
Onchocerca volvulus 0.0046 0.0165 0.2226
Giardia lamblia DNA topoisomerase II 0.0041 0.014 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0018 0.0848
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0022 0.1049
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.005 0.2401
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0136 0.0178
Echinococcus granulosus ubiquitin specific protease 41 0.0035 0.011 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.005 0.2401
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0022 0.1049
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0095 0.0125
Echinococcus multilocularis peregrin 0.0035 0.0107 0.0127
Plasmodium vivax JmjC domain containing protein 0.0028 0.0072 0.1065
Schistosoma mansoni jumonji/arid domain-containing protein 0.0113 0.0512 0.0671
Schistosoma mansoni ap endonuclease 0.0018 0.0018 0.0024
Mycobacterium leprae Isocitrate lyase 0.0913 0.4649 0.4547
Echinococcus granulosus lysine specific demethylase 6a 0.0028 0.0072 0.0082
Trypanosoma cruzi DNA topoisomerase II, putative 0.0039 0.0127 0.6288
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0028 0.0072 0.0749
Loa Loa (eye worm) hypothetical protein 0.0117 0.0533 0.48
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0161 0.0199
Loa Loa (eye worm) hypothetical protein 0.0026 0.006 0.0441
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0136 0.0178
Schistosoma mansoni hypothetical protein 0.0019 0.0027 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.005 0.2401
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0018 0.0051
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0145 0.0678 0.0502
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0022 0.0323
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0046 0.0165 0.1367
Loa Loa (eye worm) hypothetical protein 0.0029 0.0076 0.0588
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0136 0.0178
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0035 0.011 0.698
Plasmodium vivax glutathione reductase, putative 0.0053 0.0201 0.2971
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0095 0.0112
Echinococcus multilocularis cpg binding protein 0.0113 0.0509 0.0654
Onchocerca volvulus Huntingtin homolog 0.0117 0.0533 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0088
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0022 0.0022
Plasmodium falciparum JmjC domain-containing protein, putative 0.0028 0.0072 0.1066
Brugia malayi Thioredoxin reductase 0.0053 0.0201 0.1701
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0201 0.0201
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0022 0.1049
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0121 0.0553 0.0375
Plasmodium falciparum glutathione reductase 0.0018 0.0022 0.0325
Schistosoma mansoni bromodomain containing protein 0.0065 0.0264 0.0346
Echinococcus multilocularis tar DNA binding protein 0.0131 0.0606 0.0782
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0072 0.0552
Brugia malayi F/Y-rich N-terminus family protein 0.0044 0.0157 0.1285
Schistosoma mansoni zinc finger protein 0.0014 0.0001 0.0001
Leishmania major DNA topoisomerase ii 0.0039 0.0127 0.6288
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0034 0.0101 0.012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0022 0.1049
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0022 0.1049
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0145 0.0678 1
Echinococcus granulosus lamin 0.0026 0.006 0.0066
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0201 0.0252
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0145 0.0678 1
Brugia malayi hypothetical protein 0.0117 0.0533 0.4774
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0145 0.0678 0.703
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0035 0.011 0.0131
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0022 0.1049
Plasmodium falciparum phd finger protein, putative 0.0033 0.0095 0.1405
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.005 0.0186 0.2737
Echinococcus multilocularis zinc finger protein 0.0024 0.0053 0.0056
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0036 0.0112 0.0135
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0135 0.0623 0.0623
Plasmodium vivax DNA topoisomerase II, putative 0.0043 0.0149 0.2203
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0032 0.0094 0.0111
Schistosoma mansoni phosphatidylserine receptor 0.0028 0.0072 0.0095
Brugia malayi PHD-finger family protein 0.0033 0.0095 0.0717
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0041 0.0136 0.1143
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.0606 0.5453
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0061 0.0068
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.1949 1 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.0678 0.6139
Toxoplasma gondii exonuclease III APE 0.0018 0.0018 0.0186
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0028 0.0072 0.0095
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0072 0.0552
Brugia malayi intermediate filament protein 0.0026 0.006 0.0392
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0021 0.0028
Schistosoma mansoni peptidase Clp (S14 family) 0.0145 0.0678 0.0887
Brugia malayi hypothetical protein 0.0226 0.1096 1
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0606 0.0793
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0022 0.1049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0082
Toxoplasma gondii thioredoxin reductase 0.0053 0.0201 0.2088
Echinococcus multilocularis survival motor neuron protein 1 0.0226 0.1096 0.1424
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0776 0.3937 0.5148
Loa Loa (eye worm) histone methyltransferase 0.0032 0.0094 0.0756
Echinococcus multilocularis lysine specific demethylase 6a 0.0028 0.0072 0.0082
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0022 0.0227
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0039 0.0127 0.6288
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0046 0.0164 0.1402
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.005 0.2401
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0032 0.0094 0.0111
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0022 0.0331
Brugia malayi Probable ClpP-like protease 0.0145 0.0678 0.612
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0005 0.0006
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0022 0.0323
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0095 0.0419 0.0238
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0022 0.1049
Schistosoma mansoni zinc finger protein 0.0024 0.0053 0.0069
Echinococcus multilocularis lamin 0.0026 0.006 0.0066
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0201 0.2971
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.005 0.0186 0.2738
Mycobacterium ulcerans isocitrate lyase AceAb 0.1949 1 1
Schistosoma mansoni hypothetical protein 0.0033 0.0095 0.0125
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0022 0.0323
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0173 0.082 0.1062
Brugia malayi PAS domain containing protein 0.0047 0.0171 0.1422
Schistosoma mansoni tyrosine kinase 0.0264 0.1293 0.1692
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0022 0.0325
Schistosoma mansoni survival motor neuron protein 0.0046 0.0165 0.0216
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0022 0.0323
Echinococcus granulosus phd:f box containing protein 0.0028 0.0072 0.0082
Loa Loa (eye worm) hypothetical protein 0.0117 0.0533 0.48
Trypanosoma cruzi DNA topoisomerase II, putative 0.0039 0.0127 0.6288
Loa Loa (eye worm) hypothetical protein 0.0033 0.0095 0.0764
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0095 0.1404
Schistosoma mansoni jumonji domain containing protein 0.0028 0.0072 0.0095
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0036 0.0112 0.0135
Brugia malayi Bromodomain containing protein 0.0036 0.0112 0.0876
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0072 0.3557
Brugia malayi hypothetical protein 0.0159 0.0747 0.6761
Brugia malayi CXXC zinc finger family protein 0.0105 0.0468 0.4177
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0034 0.0102 0.5033
Schistosoma mansoni cpg binding protein 0.0105 0.0468 0.0613
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.0606 0.5477
Plasmodium falciparum DNA topoisomerase 2 0.0043 0.0149 0.2205
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.0136 0.0166
Loa Loa (eye worm) jmjC domain-containing protein 0.0113 0.0512 0.4612
Echinococcus granulosus peregrin 0.0035 0.0107 0.0127
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.1949 1 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0035 0.011 0.0144
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0171 0.0224
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0041 0.0136 0.1097
Loa Loa (eye worm) RNA binding protein 0.0131 0.0606 0.5477
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0247 0.0311
Echinococcus multilocularis dnaJ subfamily B 0.1492 0.764 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0145 0.0678 0.703
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0022 0.0227
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0018 0.0011
Brugia malayi jmjC domain containing protein 0.0173 0.082 0.7437
Loa Loa (eye worm) TOPoisomerase family member 0.0043 0.0149 0.1264
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0018 0.1203
Brugia malayi jmjC domain containing protein 0.0028 0.0072 0.0504
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.006 0.0392
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.005 0.2401
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0145 0.0678 0.0678
Schistosoma mansoni intermediate filament proteins 0.0026 0.006 0.0079
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0067 0.0088
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0022 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.005 0.2401
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0018 0.0265
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0009 0.0012

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 305 nM BindingDB_Patents: Mobility-Shift kinase assay. Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary LabChip technology. The off-chip incubation mobility-shift kinase assay uses a microfluidic chip to measure the conversion of a fluorescent peptide substrate to a phosphorylated product. The reaction mixture, from a microtiter plate well, is introduced through a capillary sipper onto the chip, where the nonphosphorylated substrate and phosphorylated product are separated by electrophoresis and detected via laser induced fluorescence. The signature of the fluorescence signal over time reveals the extent of the reaction. The phosphorylated product migrates through the chip faster than the non-phosphorylated substrate, and signals from the two forms of the peptide appear as distinct peaks. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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