Detailed information for compound 1999324

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 428.486 | Formula: C24H24N6O2
  • H donors: 1 H acceptors: 3 LogP: 2.52 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1n(C)cnc2c1c(NCc1ccncc1)nc(c2)c1ccc(cc1)N1CCOCC1
  • InChi: 1S/C24H24N6O2/c1-29-16-27-21-14-20(18-2-4-19(5-3-18)30-10-12-32-13-11-30)28-23(22(21)24(29)31)26-15-17-6-8-25-9-7-17/h2-9,14,16H,10-13,15H2,1H3,(H,26,28)
  • InChiKey: JLMQWYWLIRROLL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens spleen tyrosine kinase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tyrosine protein kinase shark Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131855 All targets in OG5_131855
Echinococcus multilocularis tyrosine protein kinase shark Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma japonicum ko:K05855 spleen tyrosine kinase, putative Get druggable targets OG5_131855 All targets in OG5_131855
Schistosoma japonicum ko:K08253 non-specific protein-tyrosine kinase [EC2.7.10.2], putative Get druggable targets OG5_131855 All targets in OG5_131855
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0095 0.1404
Loa Loa (eye worm) hypothetical protein 0.0066 0.027 0.2372
Plasmodium falciparum DNA gyrase subunit B 0.0014 0.0000094672 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0082
Mycobacterium tuberculosis Probable dehydrogenase 0.0121 0.0553 0.0553
Schistosoma mansoni survival motor neuron protein 0.0046 0.0165 0.0216
Echinococcus granulosus peptidase Clp S14 family 0.0095 0.0419 0.0537
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0201 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.0136 0.0166
Echinococcus multilocularis peptidase Clp (S14 family) 0.0095 0.0419 0.0537
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0022 0.0227
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0145 0.0678 0.0876
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0022 0.1049
Loa Loa (eye worm) hypothetical protein 0.0145 0.0678 0.6139
Schistosoma mansoni tyrosine kinase 0.0264 0.1293 0.1692
Loa Loa (eye worm) hypothetical protein 0.0029 0.0076 0.0588
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0121 0.0553 0.0553
Brugia malayi PHD-finger family protein 0.0018 0.0022 0.0037
Leishmania major hypothetical protein, conserved 0.0028 0.0072 0.3557
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0606 0.0793
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.005 0.2401
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0145 0.0678 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.006 0.0441
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.005 0.2401
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.005 0.2401
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.0606 0.5453
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0145 0.0678 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0022 0.0323
Mycobacterium ulcerans isocitrate lyase AceAb 0.1949 1 1
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0095 0.0764
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.005 0.2401
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0022 0.0331
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0275 0.2418
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0095 0.0419 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.005 0.2401
Schistosoma mansoni phosphatidylserine receptor 0.0028 0.0072 0.0095
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0095 0.0112
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0022 0.1049
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0022 0.0016
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0072 0.0552
Plasmodium falciparum thioredoxin reductase 0.0053 0.0201 0.2972
Brugia malayi PAS domain containing protein 0.0047 0.0171 0.1422
Plasmodium falciparum DNA topoisomerase 2 0.0043 0.0149 0.2205
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0009 0.0012
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0022 0.1049
Loa Loa (eye worm) TAR-binding protein 0.0131 0.0606 0.5477
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0022 0.0325
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0035 0.011 0.0131
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.005 0.2401
Leishmania major mitochondrial DNA topoisomerase II 0.0034 0.0102 0.5033
Loa Loa (eye worm) RNA binding protein 0.0131 0.0606 0.5477
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0606 0.0793
Echinococcus multilocularis lamin 0.0026 0.006 0.0066
Schistosoma mansoni hypothetical protein 0.0014 0.0001 0.0001
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0201 0.0252
Echinococcus multilocularis survival motor neuron protein 1 0.0226 0.1096 0.1424
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.005 0.0186 0.2737
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0201 0.0201
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0026 0.0061 0.0068
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0135 0.0623 0.0623
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0043 0.0149 0.1219
Loa Loa (eye worm) hypothetical protein 0.0226 0.1096 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0021 0.0028
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0095 0.0419 0.0419
Echinococcus multilocularis JmjC domain containing protein 4 0.0028 0.0072 0.0082
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0022 0.1049
Echinococcus granulosus dnaJ subfamily B 0.1492 0.764 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0018 0.0848
Schistosoma mansoni tyrosine kinase 0.0258 0.1261 0.1651
Schistosoma mansoni protein phosphatase 2C 0.0028 0.0072 0.0095
Schistosoma mansoni zinc finger protein 0.0024 0.0053 0.0069
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0035 0.011 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.011 0.698
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0552
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0021 0.0016
Schistosoma mansoni hypothetical protein 0.0019 0.0027 0.0035
Onchocerca volvulus Huntingtin homolog 0.0117 0.0533 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.005 0.2401
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.005 0.2401
Brugia malayi intermediate filament protein 0.0026 0.006 0.0392
Mycobacterium ulcerans isocitrate lyase Icl 0.1949 1 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0009 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0606 0.0793
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0095 0.0112
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0108 0.0129
Loa Loa (eye worm) hypothetical protein 0.0117 0.0533 0.48
Onchocerca volvulus 0.0035 0.0108 0.1007
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0035 0.011 0.0851
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0046 0.0165 0.1367
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.005 0.2401
Echinococcus multilocularis peregrin 0.0035 0.0107 0.0127
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0022 0.0227
Chlamydia trachomatis DNA gyrase subunit B 0.0023 0.0048 0.0702
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0145 0.0678 0.0502
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0031 0.0088 0.0593
Schistosoma mansoni jumonji domain containing protein 0.0028 0.0072 0.0095
Loa Loa (eye worm) TOPoisomerase family member 0.0043 0.0149 0.1264
Schistosoma mansoni zinc finger protein 0.0014 0.0001 0.0001
Loa Loa (eye worm) glutathione reductase 0.0053 0.0201 0.1744
Toxoplasma gondii histone lysine methyltransferase SET1 0.0201 0.0964 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0145 0.0678 0.703
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0088
Plasmodium falciparum phd finger protein, putative 0.0033 0.0095 0.1405
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0035 0.011 0.7544
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0247 0.0311
Mycobacterium leprae Isocitrate lyase 0.0913 0.4649 0.4547
Brugia malayi hypothetical protein 0.0226 0.1096 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0105 0.0468 0.4207
Brugia malayi Bromodomain containing protein 0.0076 0.0321 0.2811
Brugia malayi jmjC domain containing protein 0.0113 0.0512 0.4585
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.011 0.5425
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0145 0.0678 1
Onchocerca volvulus Huntingtin homolog 0.0117 0.0533 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0136 0.0178
Brugia malayi jmjC domain containing protein 0.0028 0.0072 0.0504
Loa Loa (eye worm) hypothetical protein 0.0117 0.0533 0.48
Loa Loa (eye worm) hypothetical protein 0.0073 0.0307 0.2714
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0022 0.0323
Leishmania major DNA topoisomerase ii 0.0039 0.0127 0.6288
Loa Loa (eye worm) histone methyltransferase 0.0032 0.0094 0.0756
Brugia malayi jmjC domain containing protein 0.0028 0.0072 0.0504
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0022 0.0323
Brugia malayi jmjC domain containing protein 0.0028 0.0072 0.0504
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.011 0.5425
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0028 0.0072 0.0749
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0032 0.0094 0.0111
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0121 0.0553 0.0553
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0173 0.082 0.1062
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0018 0.0018
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0035 0.011 0.0131
Echinococcus granulosus JmjC domain containing protein 4 0.0028 0.0072 0.0082
Brugia malayi Bromodomain containing protein 0.0035 0.0107 0.0823
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0035 0.011 0.5425
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0022 0.1049
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0035 0.011 0.7343
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0201 0.0252
Echinococcus granulosus jumonji domain containing 1A 0.0028 0.0072 0.0082
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0022 0.1049
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0072 0.0552
Onchocerca volvulus 0.0105 0.0468 0.8638
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0145 0.0678 0.703
Schistosoma mansoni hypothetical protein 0.1492 0.764 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.006 0.0441
Schistosoma mansoni lamin 0.0026 0.006 0.0079
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0022 0.1049
Brugia malayi hypoxia-induced factor 1 0.0146 0.0683 0.6171
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0022 0.1049
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0043 0.0149 0.0183
Plasmodium vivax DNA topoisomerase II, putative 0.0043 0.0149 0.2203
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0022 0.0022
Brugia malayi PHD-finger family protein 0.0029 0.0078 0.0561
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0034 0.0101 0.012
Echinococcus multilocularis lysine specific demethylase 6a 0.0028 0.0072 0.0082
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0022 0.0323
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.005 0.2401
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0034 0.0102 0.5033
Echinococcus granulosus zinc finger protein 0.0024 0.0053 0.0056
Leishmania major trypanothione reductase 0.0053 0.0201 1
Brugia malayi Thioredoxin reductase 0.0053 0.0201 0.1701
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.005 0.2401
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0067 0.0075
Toxoplasma gondii DNA topoisomerase 2, putative 0.0043 0.0149 0.1549
Brugia malayi hypothetical protein 0.0159 0.0747 0.6761
Echinococcus granulosus lamin dm0 0.0026 0.006 0.0066
Plasmodium vivax glutathione reductase, putative 0.0053 0.0201 0.2971
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0043 0.0149 0.1219
Schistosoma mansoni lamin 0.0026 0.006 0.0079
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0028 0.0072 0.0749
Plasmodium falciparum JmjC domain-containing protein, putative 0.0028 0.0072 0.1066
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.0136 0.0166
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0095 0.0987
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0018 0.0265
Loa Loa (eye worm) hypothetical protein 0.0029 0.0076 0.0588
Loa Loa (eye worm) hypothetical protein 0.0036 0.0113 0.0926
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.1949 1 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0135 0.0623 0.0446
Trypanosoma brucei DNA topoisomerase ii 0.0034 0.0102 0.5033
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0035 0.011 0.0144
Loa Loa (eye worm) hypothetical protein 0.0046 0.0164 0.1402
Trichomonas vaginalis DNA topoisomerase II, putative 0.0043 0.0149 1
Echinococcus granulosus lysine specific demethylase 5A 0.0113 0.0512 0.0659
Mycobacterium tuberculosis Probable oxidoreductase 0.0135 0.0623 0.0623
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0022 0.1049
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0031 0.0088 0.0593
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0022 0.0022
Giardia lamblia PHD finger protein 15 0.0033 0.0095 0.6353
Schistosoma mansoni bromodomain containing protein 0.0065 0.0264 0.0346
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0018 0.0848
Loa Loa (eye worm) hypothetical protein 0.0038 0.0124 0.1031
Schistosoma mansoni hypothetical protein 0.0046 0.0165 0.0216
Trypanosoma cruzi DNA topoisomerase II, putative 0.0039 0.0127 0.6288
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.005 0.2401
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0035 0.011 0.698
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0035 0.011 0.0131
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0145 0.0678 1
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0017 0.0015 0.022
Echinococcus granulosus peregrin 0.0035 0.0107 0.0127
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0022 0.0022
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0018 0.0018
Echinococcus granulosus tar DNA binding protein 0.0131 0.0606 0.0782
Giardia lamblia DNA topoisomerase II 0.0041 0.014 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0121 0.0553 0.0375
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0247 0.0311
Onchocerca volvulus Alhambra homolog 0.0033 0.0095 0.0741
Schistosoma mansoni ap endonuclease 0.0018 0.0018 0.0024
Echinococcus multilocularis phd:f box containing protein 0.0028 0.0072 0.0082
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0022 0.0016
Echinococcus granulosus tyrosine protein kinase shark 0.0264 0.1293 0.1682
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0043 0.0149 0.0183
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0145 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0035 0.011 0.0898
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0036 0.0112 0.0135
Echinococcus granulosus lysine specific demethylase 6a 0.0028 0.0072 0.0082
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0034 0.0102 0.5033
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.005 0.0186 0.2738
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0061 0.0068
Echinococcus granulosus intermediate filament protein 0.0026 0.006 0.0066
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0022 0.1049
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.011 0.5425
Schistosoma mansoni cpg binding protein 0.0113 0.0509 0.0666
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0022 0.1049
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.1949 1 1
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0161 0.0199
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0021 0.0028
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.006 0.0392
Trypanosoma brucei trypanothione reductase 0.0053 0.0201 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0022 0.0323
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0035 0.011 0.0144
Plasmodium falciparum glutathione reductase 0.0053 0.0201 0.2972
Echinococcus granulosus mixed lineage leukemia protein mll 0.0026 0.0061 0.0068
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0018 0.0011
Schistosoma mansoni hypothetical protein 0.0033 0.0095 0.0125
Plasmodium vivax JmjC domain containing protein 0.0028 0.0072 0.1065
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0036 0.0112 0.0135
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0028 0.0072 0.0095
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0022 0.1049
Schistosoma mansoni jumonji/arid domain-containing protein 0.0113 0.0512 0.0671
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0108 0.0833
Schistosoma mansoni ap endonuclease 0.0018 0.0018 0.0024
Echinococcus multilocularis ubiquitin specific protease 41 0.0035 0.011 0.0131
Echinococcus granulosus ubiquitin specific protease 41 0.0035 0.011 0.0131
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0037 0.0116 0.0152
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0005 0.0006
Echinococcus granulosus phd:f box containing protein 0.0028 0.0072 0.0082
Schistosoma mansoni phd/f-box containing protein 0.0028 0.0072 0.0095
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0118
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0015 0.0219
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0034 0.0101 0.012
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0018 0.0848
Schistosoma mansoni single-minded 0.0047 0.0171 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.005 0.2401
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0118
Echinococcus multilocularis jumonji domain containing 1A 0.0028 0.0072 0.0082
Schistosoma mansoni cpg binding protein 0.0105 0.0468 0.0613
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0018 0.0264
Brugia malayi Probable ClpP-like protease 0.0145 0.0678 0.612
Echinococcus multilocularis lysine specific demethylase 5A 0.0105 0.0472 0.0606
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0108 0.0108
Brugia malayi jmjC domain containing protein 0.0028 0.0072 0.0504
Brugia malayi CXXC zinc finger family protein 0.0105 0.0468 0.4177
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.0136 0.0166
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0021 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0606 0.0793
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0171 0.0224
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0061 0.0068
Toxoplasma gondii exonuclease III APE 0.0018 0.0018 0.0186
Schistosoma mansoni cpg binding protein 0.0113 0.0509 0.0666
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0022 0.0022
Schistosoma mansoni jumonji/arid domain-containing protein 0.0113 0.0512 0.0671
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0018 0.0051
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0606 0.0793
Echinococcus multilocularis tyrosine protein kinase shark 0.0264 0.1293 0.1682
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0145 0.0678 1
Onchocerca volvulus 0.0046 0.0165 0.2226
Loa Loa (eye worm) hypothetical protein 0.0025 0.0058 0.0418
Echinococcus multilocularis zinc finger protein 0.0024 0.0053 0.0056
Loa Loa (eye worm) jmjC domain-containing protein 0.0113 0.0512 0.4612
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0173 0.082 0.1062
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0161 0.0199
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0022 0.0037
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0072 0.3557
Toxoplasma gondii hypothetical protein 0.005 0.0186 0.1924
Schistosoma mansoni peptidase Clp (S14 family) 0.0145 0.0678 0.0887
Echinococcus granulosus cpg binding protein 0.0113 0.0509 0.0654
Toxoplasma gondii thioredoxin reductase 0.0053 0.0201 0.2088
Schistosoma mansoni intermediate filament proteins 0.0026 0.006 0.0079
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0031 0.0088 0.0593
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0095 0.0987
Mycobacterium tuberculosis Probable reductase 0.0121 0.0553 0.0553
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0022 0.1049
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0022 0.1049
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0072 0.0552
Echinococcus multilocularis musashi 0.0026 0.006 0.0066
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0041 0.0136 0.1097
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0095 0.0419 0.0419
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0136 0.0178
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0032 0.0094 0.0111
Brugia malayi Bromodomain containing protein 0.0036 0.0112 0.0876
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.0136 0.0166
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0145 0.0678 0.0876
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0135 0.0623 0.0623
Loa Loa (eye worm) intermediate filament protein 0.0026 0.006 0.0441
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0018 0.0264
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0 0.0002
Echinococcus multilocularis tar DNA binding protein 0.0131 0.0606 0.0782
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0136 0.0178
Echinococcus granulosus lamin 0.0026 0.006 0.0066
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.0606 0.5477
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0028 0.0072 0.3557
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.005 0.2401
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.0683 0.6191
Brugia malayi hypothetical protein 0.0117 0.0533 0.4774
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.005 0.2401
Schistosoma mansoni jumonji domain containing protein 0.0151 0.0707 0.0925
Trichomonas vaginalis helicase, putative 0.0024 0.005 0.2401
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0121 0.0553 0.0553
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0041 0.0136 0.1143
Brugia malayi Probable DNA topoisomerase II 0.0043 0.0149 0.1219
Echinococcus multilocularis cpg binding protein 0.0113 0.0509 0.0654
Brugia malayi PHD-finger family protein 0.0033 0.0095 0.0717
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0067 0.0075
Echinococcus granulosus survival motor neuron protein 1 0.0226 0.1096 0.1424
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0039 0.0127 0.6288
Plasmodium falciparum glutathione reductase 0.0018 0.0022 0.0325
Echinococcus multilocularis lamin dm0 0.0026 0.006 0.0066
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0022 0.1049
Trypanosoma cruzi DNA topoisomerase II, putative 0.0039 0.0127 0.6288
Echinococcus granulosus single minded 2 0.0035 0.0108 0.0129
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0022 0.1049
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0022 0.0325
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0022 0.0029
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0145 0.0678 1
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0022 0.0307
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0018 0.0264
Brugia malayi RNA binding protein 0.0131 0.0606 0.5453
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0022 0.1049
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0067 0.0088
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0201 0.2971
Loa Loa (eye worm) PHD-finger family protein 0.0019 0.0027 0.0133
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0222 0.1076 0.1408
Brugia malayi jmjC domain containing protein 0.0173 0.082 0.7437
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0201 0.1744
Brugia malayi glutathione reductase 0.0053 0.0201 0.1701
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.005 0.2401
Loa Loa (eye worm) hypothetical protein 0.0033 0.0095 0.0764
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0121 0.0553 0.0553
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0035 0.011 0.698
Schistosoma mansoni DNA topoisomerase II 0.0043 0.0149 0.0196
Loa Loa (eye worm) hypothetical protein 0.0159 0.0747 0.6777
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0095 0.0125
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0145 0.0678 0.0678
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0018 0.0848
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.005 0.0186 0.2737
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0018 0.1203
Brugia malayi TAR-binding protein 0.0131 0.0606 0.5453
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0039 0.0127 0.6288
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.005 0.2401
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0776 0.3937 0.5148
Treponema pallidum NADH oxidase 0.0018 0.0022 0.0323
Entamoeba histolytica DNA topoisomerase II, putative 0.0043 0.0149 1
Plasmodium falciparum thioredoxin reductase 0.0018 0.0022 0.0325
Brugia malayi F/Y-rich N-terminus family protein 0.0044 0.0157 0.1285
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0072 0.3557
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0022 0.0307
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0018 0.0011
Echinococcus multilocularis dnaJ subfamily B 0.1492 0.764 1
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.1949 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0552

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 305 nM BindingDB_Patents: Mobility-Shift kinase assay. Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary LabChip technology. The off-chip incubation mobility-shift kinase assay uses a microfluidic chip to measure the conversion of a fluorescent peptide substrate to a phosphorylated product. The reaction mixture, from a microtiter plate well, is introduced through a capillary sipper onto the chip, where the nonphosphorylated substrate and phosphorylated product are separated by electrophoresis and detected via laser induced fluorescence. The signature of the fluorescence signal over time reveals the extent of the reaction. The phosphorylated product migrates through the chip faster than the non-phosphorylated substrate, and signals from the two forms of the peptide appear as distinct peaks. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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