TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 440.492 | Formula: C23H28N4O5
H donors: 4 H acceptors: 3 LogP: 1.29 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1OCC(CNCC(=O)Nc1ccc(cc1)C1=NNC(=O)CC1C)O
InChi: 1S/C23H28N4O5/c1-15-11-21(29)26-27-23(15)16-7-9-17(10-8-16)25-22(30)13-24-12-18(28)14-32-20-6-4-3-5-19(20)31-2/h3-10,15,18,24,28H,11-14H2,1-2H3,(H,25,30)(H,26,29)
InChiKey: LXDCNDLUKHSICP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0029	0.0123
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0023	0.0359	0.1527
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0023	0.0359	0.1527
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0099	0.1489
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0094	0.1581	0.6769
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0008	0.0099	0.0098
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0008	0.0099	0.2746
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0094	0.1581	0.7394
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0008	0.0099	0.2746
Echinococcus multilocularis	serine protein kinase ATM	0.0023	0.0359	0.0358
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0008	0.0099	0.1103
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0008	0.0099	0.0099
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0284	0.4018
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0008	0.0099	0.1489
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0008	0.0099	0.1103
Onchocerca volvulus		0.001	0.0137	0.0521
Echinococcus granulosus	sterile alpha and tir motif containing protein	0.0012	0.0175	0.0175
Trichomonas vaginalis	c2h2 zinc finger protein, putative	0.0012	0.0175	0.2638
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0137	0.2063
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0008	0.0099	0.1103
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0284	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0359	0.5405
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0175	0.0817
Schistosoma mansoni	nAChR subunit	0.0094	0.1581	0.673
Loa Loa (eye worm)	phosphatidylinositol 3	0.0008	0.0099	0.0461
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0094	0.1581	0.1581
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0008	0.0099	0.0203
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0008	0.0099	0.0595
Echinococcus granulosus	nAChR subunit	0.0051	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1581	0.7394
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0224	0.3378
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0029	0.0123
Schistosoma mansoni	hypothetical protein	0.0004	0.0029	0.0123
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0094	0.1581	0.7394
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0094	0.1581	0.7394
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0008	0.0099	0.2746
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0137	0.2063
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0175	0.0817
Loa Loa (eye worm)	hypothetical protein	0.001	0.0137	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1581	0.7394
Schistosoma mansoni	nAChR subunit	0.0094	0.1581	0.673
Onchocerca volvulus		0.0051	0.0835	0.3889
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0094	0.1581	0.1581
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0008	0.0099	0.0203
Onchocerca volvulus		0.0051	0.0835	0.3889
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0008	0.0099	0.0099
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0023	0.0359	0.0359
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0094	0.1581	0.7394
Echinococcus granulosus	CCR4 NOT transcription complex subunit 6	0.0004	0.0029	0.0029
Echinococcus granulosus	replication factor c subunit 1	0.001	0.0137	0.0137
Schistosoma mansoni	sarm1	0.0012	0.0175	0.0745
Brugia malayi	hypothetical protein	0.0012	0.0175	0.0749
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0008	0.0099	0.2746
Loa Loa (eye worm)	tnks protein	0.0127	0.2138	1
Trypanosoma brucei	poly(adp-ribose) polymerase	0.002	0.0304	0.4343
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0043	0.071	0.304
Plasmodium vivax	hypothetical protein	0.0008	0.0099	0.2746
Echinococcus granulosus	nibrin	0.001	0.0137	0.0137
Schistosoma mansoni	ap endonuclease	0.0019	0.0284	0.1208
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0008	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0029	0.0133
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0018	0.0269	0.0269
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0099	0.0461
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0041	0.0663	0.1773
Loa Loa (eye worm)	toll and interleukin 1 receptor domain-containing protein isoform f	0.0012	0.0175	0.0817
Echinococcus granulosus	poly ADP ribose polymerase 1	0.002	0.0304	0.0304
Brugia malayi	topoisomerase	0.001	0.0137	0.0586
Loa Loa (eye worm)	hypothetical protein	0.0043	0.071	0.332
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0137	0.2063
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0094	0.1581	0.6769
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0041	0.0663	0.5391
Loa Loa (eye worm)	ACC-1 protein	0.0094	0.1581	0.7394
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0094	0.1581	0.673
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0094	0.1581	0.6769
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0094	0.1581	0.1581
Entamoeba histolytica	hypothetical protein	0.0072	0.1206	1
Onchocerca volvulus		0.0043	0.071	0.3286
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0018	0.0269	0.0269
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0008	0.0099	0.1103
Loa Loa (eye worm)	hypothetical protein	0.0043	0.071	0.332
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1581	0.7394
Loa Loa (eye worm)	phosphatidylinositol 3	0.0008	0.0099	0.0461
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Echinococcus multilocularis	SAM domain containing protein	0.0012	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0043	0.071	0.332
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0008	0.0099	0.0203
Trichomonas vaginalis	replication factor C large subunit, putative	0.001	0.0137	0.2063
Schistosoma mansoni	nAChR subunit	0.0043	0.071	0.3023
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0008	0.0099	0.1489
Brugia malayi	Neurabin protein 1	0.0012	0.0175	0.0749
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.002	0.0304	0.1296
Echinococcus multilocularis	poly (adp ribose) polymerase 2	0.002	0.0304	0.0304
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0094	0.1581	0.1581
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0304	0.4589
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0224	0.1047
Loa Loa (eye worm)	hypothetical protein	0.001	0.0137	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0835	0.3906
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0023	0.0359	0.2801
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0008	0.0099	0.1103
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0094	0.1581	0.1581
Echinococcus multilocularis	nAChR subunit	0.0094	0.1581	0.1581
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0008	0.0099	0.0196
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.002	0.0304	0.08
Echinococcus multilocularis	nibrin	0.001	0.0137	0.0137
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0284	0.1326
Echinococcus granulosus	poly adp ribose polymerase 2	0.002	0.0304	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0043	0.071	0.332
Schistosoma mansoni	nAChR subunit	0.0094	0.1581	0.673
Onchocerca volvulus		0.0094	0.1581	0.7486
Echinococcus multilocularis	synaptojanin 1	0.0004	0.0029	0.0028
Echinococcus multilocularis	sterile alpha and tir motif containing protein	0.0012	0.0175	0.0175
Echinococcus granulosus	tankyrase	0.0139	0.2346	0.2346
Giardia lamblia	hypothetical protein	0.0004	0.0029	0.0434
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0094	0.1581	0.1581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.0137	0.0583
Schistosoma mansoni	synaptojanin	0.0004	0.0029	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1581	0.7394
Loa Loa (eye worm)	phosphatidylinositol 3	0.0008	0.0099	0.0461
Brugia malayi	Pax transcription activation domain interacting protein	0.001	0.0137	0.0586
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0284	1
Echinococcus granulosus	nAChR subunit	0.0094	0.1581	0.1581
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0008	0.0099	0.1489
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0404	0.6084
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0359	0.5405
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0008	0.0099	0.0595
Entamoeba histolytica	zinc finger protein, putative	0.002	0.0304	0.2341
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0835	0.3906
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0043	0.071	0.332
Schistosoma mansoni	hypothetical protein	0.0012	0.0175	0.0745
Schistosoma mansoni	topbp1	0.001	0.0137	0.0583
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0137	0.2063
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1581	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1581	0.7394
Schistosoma mansoni	hypothetical protein	0.0072	0.1206	0.5134
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0041	0.0663	0.2841
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0835	0.3906
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0008	0.0099	0.1489
Schistosoma mansoni	ocrl type II inositol 5-phosphatase	0.0004	0.0029	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0029	0.0133
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1581	0.7394
Onchocerca volvulus		0.0043	0.071	0.3286
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0175	0.2638
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0026	0.0404	0.5906
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0284	0.1215
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0041	0.0663	0.0663
Brugia malayi	Cation transporter family protein	0.0094	0.1581	0.6769
Onchocerca volvulus		0.0094	0.1581	0.7486
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0094	0.1581	0.1581
Entamoeba histolytica	hypothetical protein	0.0008	0.0099	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0359	0.1676
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0041	0.0663	0.0663
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0008	0.0099	0.0099
Echinococcus granulosus	SAM domain containing protein	0.0012	0.0175	0.0175
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0094	0.1581	0.1581
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0137	0.1703
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0041	0.0663	0.1773
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0008	0.0099	0.0595
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0008	0.0099	0.2746
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0008	0.0099	0.1489
Loa Loa (eye worm)	hypothetical protein	0.001	0.0137	0.0639
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0029	0.0133
Brugia malayi	Liprin-alpha 2	0.0012	0.0175	0.0749
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0175	0.0817
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0029	0.0133
Schistosoma mansoni	neutral sphingomyelinase	0.0004	0.0029	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0175	0.0817
Loa Loa (eye worm)	phosphatidylinositol 3	0.0041	0.0663	0.3102
Brugia malayi	hypothetical protein	0.0043	0.071	0.304
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0008	0.0099	0.1103
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1581	0.7394
Schistosoma mansoni	hypothetical protein	0.0012	0.0175	0.0745
Entamoeba histolytica	hypothetical protein	0.0072	0.1206	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Schistosoma mansoni	transcription factor LCR-F1	0.0072	0.1206	0.5134
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0008	0.0099	0.1489
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0029	0.0133
Schistosoma mansoni	hypothetical protein	0.0012	0.0175	0.0745
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0041	0.0663	1
Entamoeba histolytica	hypothetical protein	0.002	0.0304	0.2341
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0008	0.0099	0.0595
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0008	0.0099	0.0461
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0008	0.0099	0.0099
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0094	0.1581	0.6769
Echinococcus granulosus	stromal interaction molecule 1	0.0012	0.0175	0.0175
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0008	0.0099	0.0595
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0008	0.0099	0.0196
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0304	0.4589
Entamoeba histolytica	hypothetical protein	0.002	0.0304	0.2341
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0041	0.0663	0.2824
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0359	0.5405
Trichomonas vaginalis	carbon catabolite repressor protein, putative	0.0004	0.0029	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0043	0.071	0.332
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0008	0.0099	0.0098
Echinococcus multilocularis	glycine receptor subunit beta	0.0094	0.1581	0.1581
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.001	0.0137	0.0918
Echinococcus multilocularis	liprin alpha 2	0.0012	0.0175	0.0175
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0284	0.4277
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0094	0.1581	0.7394
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0094	0.1581	0.7394
Onchocerca volvulus		0.0094	0.1581	0.7486
Schistosoma mansoni	nAChR subunit	0.0094	0.1581	0.673
Echinococcus granulosus	synaptojanin 1	0.0004	0.0029	0.0029
Schistosoma mansoni	hypothetical protein	0.0018	0.0269	0.1146
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0094	0.1581	0.1581
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0094	0.1581	0.6769
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0008	0.0099	0.0203
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0137	0.0314
Entamoeba histolytica	hypothetical protein	0.0008	0.0099	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0835	0.3906
Schistosoma mansoni	nAChR subunit	0.0094	0.1581	0.673
Echinococcus granulosus	neutral sphingomyelinase	0.0004	0.0029	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0304	0.4589
Loa Loa (eye worm)	phosphatidylinositol 3	0.0008	0.0099	0.0461
Echinococcus multilocularis	tankyrase	0.0139	0.2346	0.2346
Trichomonas vaginalis	Phospholipase C precursor, putative	0.0004	0.0029	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0043	0.071	0.332
Toxoplasma gondii	FATC domain-containing protein	0.0023	0.0359	0.5197
Loa Loa (eye worm)	GABA receptor subunit	0.0051	0.0835	0.3906
Schistosoma mansoni	acetylcholine receptor-related	0.0043	0.071	0.3023
Brugia malayi	Cation transporter family protein	0.0094	0.1581	0.6769
Schistosoma mansoni	DNA ligase IV	0.001	0.0137	0.0583
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0008	0.0099	0.0423
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0008	0.0099	0.0421
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0008	0.0099	0.2746
Plasmodium falciparum	tyrosine kinase-like protein	0.0012	0.0175	0.5736
Echinococcus multilocularis		0.0008	0.0099	0.0098
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0137	0.2063
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0359	0.5405
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0137	0.2063
Brugia malayi	Tnks protein	0.0138	0.2336	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0835	0.3906
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0008	0.0099	0.0203
Leishmania major	hypothetical protein, unknown function	0.0008	0.0099	0.0196
Plasmodium falciparum	protein kinase, putative	0.0012	0.0175	0.5736
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0029	0.0123
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0043	0.071	0.071
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0404	0.1887
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0284	0.0284
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0008	0.0099	0.0196
Loa Loa (eye worm)	hypothetical protein	0.001	0.0137	0.0639
Brugia malayi	hypothetical protein	0.0043	0.071	0.304
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0041	0.0663	1
Treponema pallidum	DNA ligase (lig)	0.001	0.0137	0.4238
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0004	0.0029	0.0029
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.002	0.0304	0.1296
Entamoeba histolytica	hypothetical protein	0.0023	0.0359	0.2801
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.003	0.0477	0.7062
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0043	0.071	0.304
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0008	0.0099	0.0421
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0008	0.0099	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0175	0.0817
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0094	0.1581	0.6769
Schistosoma mansoni	cript-related	0.0004	0.0029	0.0123
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0094	0.1581	0.6769
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0008	0.0099	0.0461
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0008	0.0099	0.0423
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0404	0.6084
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0284	1
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0584	1	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0041	0.0663	0.1842
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0835	0.3906
Chlamydia trachomatis	DNA ligase	0.001	0.0137	0.5
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0284	0.4277
Brugia malayi	sterile alpha and TIR motif containing protein 1 isoform a	0.0012	0.0175	0.0749
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0023	0.0359	0.1535
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0099	0.1489
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0008	0.0099	0.1489
Toxoplasma gondii	exonuclease III APE	0.0019	0.0284	0.4018
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0041	0.0663	0.2824
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0072	0.1206	0.1206
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0029	0.0123
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0003	0.0016	0.0239
Trichomonas vaginalis	sphingomyelinase C 2 precursor, putative	0.0004	0.0029	0.0434
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0094	0.1581	0.1581
Giardia lamblia	GTOR	0.0041	0.0663	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.071	0.332
Onchocerca volvulus		0.0012	0.0175	0.0705
Brugia malayi	CCR4	0.0004	0.0029	0.0123
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0008	0.0099	0.0099
Onchocerca volvulus		0.0094	0.1581	0.7486
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0008	0.0099	0.0423
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1581	0.7394
Trypanosoma cruzi	target of rapamycin kinase 3	0.0041	0.0663	0.1842
Brugia malayi	coiled-coil like protein 1	0.0012	0.0175	0.0749
Loa Loa (eye worm)	hypothetical protein	0.001	0.0137	0.0639
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0304	0.4589
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0043	0.071	0.071
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0043	0.071	0.071
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0051	0.0835	0.3576
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0175	0.2638
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0835	0.3906
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0008	0.0099	0.0203
Onchocerca volvulus	Tankyrase homolog	0.0124	0.2102	1
Trichomonas vaginalis	type IV inositol 5-phosphatase, putative	0.0004	0.0029	0.0434
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0269	0.4057
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0094	0.1581	0.6769
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0029	0.0123
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0008	0.0099	0.0203
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0008	0.0099	0.0203
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0043	0.071	0.304
Echinococcus granulosus	liprin beta 1	0.0012	0.0175	0.0175
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0094	0.1581	0.6769
Loa Loa (eye worm)	hypothetical protein	0.0043	0.071	0.332
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0008	0.0099	0.1489
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0835	0.3906
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0284	0.0283
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0094	0.1581	0.1581
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0029	0.0133
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0284	0.0712
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0043	0.071	0.304
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0008	0.0099	0.1489
Plasmodium falciparum	replication factor C subunit 1, putative	0.001	0.0137	0.4238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Brugia malayi	hypothetical protein	0.0043	0.071	0.304
Brugia malayi	FAT domain containing protein	0.0018	0.0269	0.1152
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0008	0.0099	0.0098
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0284	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0284	0.074
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0008	0.0099	0.0196
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0304	0.4589
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0026	0.0404	0.5906
Onchocerca volvulus		0.0012	0.0175	0.0705
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0137	0.2063
Leishmania major	hypothetical protein, conserved	0.0212	0.3609	1
Entamoeba histolytica	hypothetical protein	0.002	0.0304	0.2341
Loa Loa (eye worm)	hypothetical protein	0.0043	0.071	0.332
Loa Loa (eye worm)	hypothetical protein	0.002	0.0304	0.1423
Trichomonas vaginalis	carbon catabolite repressor protein, putative	0.0004	0.0029	0.0434
Plasmodium vivax	replication factor C subunit 1, putative	0.001	0.0137	0.4238
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0008	0.0099	0.0421
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0094	0.1581	0.6769
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0043	0.071	0.304
Loa Loa (eye worm)	hypothetical protein	0.0043	0.071	0.332
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1581	0.7394
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	0.002	0.0304	0.1423
Echinococcus multilocularis	inositol polyphosphate 5 phosphatase OCRL 1	0.0004	0.0029	0.0028
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0041	0.0663	0.0663
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0094	0.1581	0.1581
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0041	0.0663	0.1842
Trichomonas vaginalis	ankyrin, putative	0.0002	0	0.0005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1581	0.7394
Giardia lamblia	Hypothetical protein	0.0008	0.0099	0.1489
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0224	0.3378
Schistosoma mansoni	carbon catabolite repressor protein	0.0004	0.0029	0.0123
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0304	0.4589
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0043	0.071	0.332
Leishmania major	phosphatidylinositol kinase, putative	0.0008	0.0099	0.0196
Entamoeba histolytica	hypothetical protein	0.0008	0.0099	0.0595
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0041	0.0663	1
Entamoeba histolytica	hypothetical protein	0.0072	0.1206	1
Onchocerca volvulus		0.0008	0.0099	0.0338
Brugia malayi	hypothetical protein	0.001	0.0137	0.0586
Schistosoma mansoni	lip-related protein (liprin) alpha	0.0012	0.0175	0.0745
Onchocerca volvulus	Putative nachr subunit	0.0094	0.1581	0.7486
Trichomonas vaginalis	carbon catabolite repressor protein, putative	0.0004	0.0029	0.0434
Schistosoma mansoni	lar interacting protein (lip)-related protein	0.0012	0.0175	0.0745
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0008	0.0099	0.1103
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0137	0.2063
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0284	1
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0008	0.0099	0.1489
Echinococcus granulosus	inositol polyphosphate 5 phosphatase OCRL 1	0.0004	0.0029	0.0029
Entamoeba histolytica	hypothetical protein	0.001	0.0137	0.0918
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Brugia malayi	hypothetical protein	0.0043	0.071	0.304
Schistosoma mansoni	tankyrase	0.0139	0.2349	1
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1581	0.7394
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0043	0.071	0.3023
Brugia malayi	hypothetical protein	0.001	0.0137	0.0586
Echinococcus multilocularis	stromal interaction molecule 1	0.0012	0.0175	0.0175
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0008	0.0099	0.0098
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0051	0.0835	0.3576
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0008	0.0099	0.1103
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0008	0.0099	0.0421
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0008	0.0099	0.0423
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0041	0.0663	0.1773
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0304	0.4589
Schistosoma mansoni	nAChR subunit	0.0094	0.1581	0.673
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0012	0.0175	0.2304
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0137	0.0314
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	0.002	0.0304	0.2341
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1581	0.7394
Schistosoma mansoni	nocturnin	0.0004	0.0029	0.0123
Echinococcus multilocularis	traf and tnf receptor associated protein	0.0004	0.0029	0.0028
Loa Loa (eye worm)	LGC-31 protein	0.0094	0.1581	0.7394
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0137	0.2063
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0094	0.1581	0.1581
Toxoplasma gondii	ATPase, AAA family protein	0.001	0.0137	0.1703
Giardia lamblia	Inositol 5-phosphatase 4	0.0004	0.0029	0.0434
Plasmodium vivax	hypothetical protein, conserved	0.0008	0.0099	0.2746
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0269	0.1257
Trichomonas vaginalis	type II inositol 5-phosphatase, putative	0.0004	0.0029	0.0434
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0008	0.0099	0.0098
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0023	0.0359	0.0358
Echinococcus multilocularis	glycine receptor subunit beta	0.0094	0.1581	0.1581
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1581	0.7394
Loa Loa (eye worm)	CCR4-NOT transcription complex subunit 6 family protein	0.0004	0.0029	0.0133
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0175	0.2638
Echinococcus granulosus	serine protein kinase ATM	0.0023	0.0359	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0029	0.0133
Echinococcus multilocularis	poly (ADP ribose) polymerase	0.002	0.0304	0.0304
Brugia malayi	hypothetical protein	0.0072	0.1206	0.5164
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0094	0.1581	0.1581
Loa Loa (eye worm)	hypothetical protein	0.0043	0.071	0.332
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.001	0.0137	0.0586
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1581	0.7394
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0041	0.0663	0.1842
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0094	0.1581	0.1581
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0008	0.0099	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1581	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1581	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0835	0.3906
Entamoeba histolytica	hypothetical protein	0.0072	0.1206	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0008	0.0099	0.1489
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0023	0.0359	0.1535
Loa Loa (eye worm)	phosphatidylinositol 3	0.0041	0.0663	0.3102
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0041	0.0663	0.1842
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0008	0.0099	0.1489
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0041	0.0663	1
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1581	0.7394
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0094	0.1581	0.673
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0099	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0105	0.1766	0.8257
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0008	0.0099	0.0595
Schistosoma mansoni	synaptojanin	0.0004	0.0029	0.0123
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0008	0.0099	0.1489
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0072	0.1206	0.1206
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0041	0.0663	0.0663
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0094	0.1581	0.1581
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0284	0.2166
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0094	0.1581	0.1581
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0304	0.4589
Echinococcus multilocularis	CCR4 NOT transcription complex subunit 6	0.0004	0.0029	0.0028
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0004	0.0029	0.0028
Onchocerca volvulus		0.0094	0.1581	0.7486
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0008	0.0099	0.0421
Echinococcus granulosus	glycine receptor subunit beta	0.0094	0.1581	0.1581
Loa Loa (eye worm)	hypothetical protein	0.001	0.0137	0.0639
Giardia lamblia	Replication factor C, subunit 1	0.001	0.0137	0.2063
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0041	0.0663	0.1773
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0284	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0023	0.0359	0.0957
Entamoeba histolytica	hypothetical protein	0.0008	0.0099	0.0595
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0041	0.0663	0.5391
Entamoeba histolytica	protein kinase rad3, putative	0.0023	0.0359	0.2801
Onchocerca volvulus		0.0008	0.0099	0.0338
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0094	0.1581	0.673
Loa Loa (eye worm)	acetylcholine receptor protein	0.0043	0.071	0.332
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0008	0.0099	0.2746
Brugia malayi	hypothetical protein	0.0043	0.071	0.304
Schistosoma mansoni	neurotransmitter gated ion channel	0.0043	0.071	0.3023
Echinococcus multilocularis	Zinc finger, PHD finger	0.0008	0.0099	0.0098
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0137	0.0314
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Echinococcus granulosus	traf and tnf receptor associated protein	0.0004	0.0029	0.0029
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0094	0.1581	0.6769
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0041	0.0663	1
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0023	0.0359	0.5197
Trichomonas vaginalis	skeletal muscle/kidney enriched inositol 5-phosphatase, putative	0.0004	0.0029	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0029	0.0133
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0008	0.0099	0.0099
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0008	0.0099	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0043	0.071	0.332
Echinococcus multilocularis	deoxyribonuclease 1 2	0.0004	0.0029	0.0028
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0359	0.5405
Trichomonas vaginalis	ocrl type II inositol 5-phosphatase, putative	0.0004	0.0029	0.0434
Schistosoma mansoni	ap endonuclease	0.0019	0.0284	0.1208
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0029	0.0123
Brugia malayi	DKFZp564C0469 protein	0.001	0.0137	0.0586
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0094	0.1581	0.1581
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0175	0.2638
Echinococcus granulosus	liprin alpha 2	0.0012	0.0175	0.0175
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0	0.0005
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.001	0.0137	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0008	0.0099	0.0461
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0051	0.0835	0.3576
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0094	0.1581	0.673
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0008	0.0099	0.0421
Onchocerca volvulus		0.0043	0.071	0.3286
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0284	0.074
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0099	0.1489
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0284	0.4277
Echinococcus granulosus	Sterile alpha motif SAM	0.0012	0.0175	0.0175
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0015	0.0224	0.0567
Schistosoma mansoni	neurotransmitter gated ion channel	0.0043	0.071	0.3023
Brugia malayi	excitatory GABA receptor EXP-1A	0.0094	0.1581	0.6769
Schistosoma mansoni	neurotransmitter gated ion channel	0.0051	0.0835	0.3556
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0041	0.0663	0.2841
Entamoeba histolytica	hypothetical protein	0.0051	0.0835	0.685
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0003	0.0016	0.0244
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0359	0.5405
Echinococcus granulosus	glycine receptor subunit beta	0.0094	0.1581	0.1581
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0094	0.1581	0.6769
Brugia malayi	WGR domain containing protein	0.002	0.0304	0.1303
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0094	0.1581	0.1581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0012	0.0175	0.5736
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0043	0.071	0.071
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0043	0.071	0.304
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0051	0.0835	0.3556
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0029	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0043	0.071	0.332
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0094	0.1581	0.1581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0359	0.5405
Loa Loa (eye worm)	ACC-1 protein	0.0094	0.1581	0.7394
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.002	0.0304	0.0304
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0008	0.0099	0.0423
Schistosoma mansoni	topbp1	0.001	0.0137	0.0583
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.0137	0.0137
Trypanosoma cruzi	hypothetical protein, conserved	0.0204	0.3474	1
Echinococcus multilocularis	liprin beta 1	0.0012	0.0175	0.0175
Entamoeba histolytica	hypothetical protein	0.002	0.0304	0.2341
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0003	0.002	0.0295
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0008	0.0099	0.0203
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0094	0.1581	0.673
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0359	0.5405
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0094	0.1581	0.673
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0008	0.0099	0.1489
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0304	0.4589
Loa Loa (eye worm)	hypothetical protein	0.0043	0.071	0.332
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0094	0.1581	0.6769
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0008	0.0099	0.0423
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0008	0.0099	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1581	0.7394
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0008	0.0099	0.0423
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0043	0.071	0.071
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0051	0.0835	0.3576
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0094	0.1581	0.6769
Schistosoma mansoni	hypothetical protein	0.0008	0.0099	0.0421
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0094	0.1581	0.6769
Echinococcus multilocularis	neutral sphingomyelinase	0.0004	0.0029	0.0028
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0008	0.0099	0.1489
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0029	0.0123
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0094	0.1581	0.6769
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0051	0.0835	0.3556
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0008	0.0099	0.2746
Trypanosoma cruzi	FHA domain containing protein, putative	0.001	0.0137	0.0314
Echinococcus multilocularis	nAChR subunit	0.0051	0.0835	0.0835
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0008	0.0099	0.1103
Schistosoma mansoni	hypothetical protein	0.0012	0.0175	0.0745
Schistosoma mansoni	nAChR subunit	0.0094	0.1581	0.673
Brugia malayi	WGR domain containing protein	0.002	0.0304	0.1303
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0008	0.0099	0.1489
Brugia malayi	hypothetical protein	0.0012	0.0175	0.0749
Brugia malayi	Cation transporter family protein	0.0094	0.1581	0.6769
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0008	0.0099	0.1103
Loa Loa (eye worm)	hypothetical protein	0.0043	0.071	0.332
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.002	0.0304	0.08
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0029	0.0123
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0041	0.0663	0.1773
Schistosoma mansoni	nAChR subunit	0.0043	0.071	0.3023
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0663	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0023	0.0359	0.0957
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0029	0.0133
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0041	0.0663	1
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0094	0.1581	0.1581
Onchocerca volvulus		0.0094	0.1581	0.7486

Activities

Activity type	Activity value	Assay description	Source	Reference
ED40 (functional)	< 4 uM kg-1	Dose required to produce a fall in blood pressure of 40 mmHg in the anesthetized rat	ChEMBL.	2892934
ED50 (functional)	= 3 uM kg-1	Dose required to produce a 50% increase in blood flow to the autoperfused hindquarters of the anesthetized rat	ChEMBL.	2892934
ID50 (functional)	= 2.6 uM kg-1	Beta1-adrenoceptor antagonsim of compound expressed as inhibition of isoprenaline-induced tachycardia in the ganglion-blocked anesthetized cat	ChEMBL.	2892934
ID50 (functional)	= 2.6 uM kg-1	Beta1-adrenoceptor antagonsim of compound expressed as inhibition of isoprenaline-induced tachycardia in the ganglion-blocked anesthetized cat	ChEMBL.	2892934
ISA (functional)	= 0.37	Intrinsic Sympathomimetic Activity (ISA) determined from the ratio of the maximal compound and isoprenaline induced tachycardia in anesthetized ganglion blocked cats following intravenous administration	ChEMBL.	2892934
ISA (functional)	= 0.37	Intrinsic Sympathomimetic Activity (ISA) determined from the ratio of the maximal compound and isoprenaline induced tachycardia in anesthetized ganglion blocked cats following intravenous administration	ChEMBL.	2892934

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL119654

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 205247