Detailed information for compound 209332

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 790.562 | Formula: C48H75ClN4OP+
  • H donors: 3 H acceptors: 1 LogP: 12.92 Rotable bonds: 24
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)N/C(=[NH+]/C1CCCCC1)/NC1CCCCC1)(CCCCC)CCCCC.[Cl-]
  • InChi: 1S/C48H73N4OP.ClH/c1-4-7-18-33-54(34-19-8-5-2,35-20-9-6-3)38-39-28-31-45(32-29-39)49-47(53)46(37-40-27-30-41-21-16-17-22-42(41)36-40)52-48(50-43-23-12-10-13-24-43)51-44-25-14-11-15-26-44;/h16-17,21-22,27-32,36,43-44,46H,4-15,18-20,23-26,33-35,37-38H2,1-3H3,(H2-,49,50,51,52,53);1H/p+1/t46-;/m0./s1
  • InChiKey: JGPDCPRNFNAICG-IDCINFOJSA-O  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.0334 0.3794
Onchocerca volvulus 0.0051 0.0101 0.01
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0159 0.0159
Onchocerca volvulus 0.0015 0.0007 0.0007
Schistosoma mansoni amine GPCR 0.0015 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0028
Brugia malayi Cytochrome P450 family protein 0.003 0.0046 0.0046
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.033 0.033
Echinococcus multilocularis neuropeptide FF receptor 2 0.0015 0.0007 0.0007
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0067 0.0812
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0035 0.0059 0.0498
Echinococcus multilocularis neuropeptides capa receptor 0.0015 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.0075 0.0162 0.1973
Onchocerca volvulus 0.0015 0.0007 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0159 0.0159
Echinococcus multilocularis sodium and chloride dependent glycine 0.0025 0.0034 0.0033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0015 0.0007 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0028
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0015 0.0007 0.0007
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.033 0.033
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0015 0.0007 0.0007
Brugia malayi hypothetical protein 0.0015 0.0007 0.0007
Schistosoma mansoni opsin-like receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0025 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Echinococcus multilocularis neuropeptide receptor 0.0015 0.0007 0.0007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0159 0.0159
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0021 0.0899
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0022 0.0028
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0159 0.0202
Mycobacterium tuberculosis Probable reductase 0.0228 0.0556 0.4722
Plasmodium falciparum thioredoxin reductase 0.0035 0.0059 0.2586
Brugia malayi GnHR receptor homolog 0.0015 0.0007 0.0007
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0067 0.294
Giardia lamblia Fructose-bisphosphate aldolase 0.0291 0.0716 0.8723
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0159 0.1347
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0059 0.0074
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0033
Schistosoma mansoni sodium/chloride dependent transporter 0.0025 0.0034 0.0034
Loa Loa (eye worm) RecQ helicase 0.0023 0.0028 0.0027
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0129 0.0129
Echinococcus granulosus G protein coupled receptor 139 0.0015 0.0007 0.0007
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0034 0.1474
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0022
Echinococcus granulosus neuropeptide Y receptor 0.0015 0.0007 0.0007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0059 0.0074
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.0345 0.0345
Echinococcus multilocularis neuropeptide Y receptor 0.0015 0.0007 0.0007
Mycobacterium ulcerans hypothetical protein 0.0074 0.0159 0.217
Echinococcus granulosus survival motor neuron protein 1 0.025 0.0611 0.0611
Echinococcus granulosus g protein coupled receptor 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0074 0.0159 0.0159
Loa Loa (eye worm) beta-lactamase 0.0074 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0525 0.1319 0.1319
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.0121 0.1684
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0143 0.0338 0.5012
Toxoplasma gondii thioredoxin reductase 0.01 0.0227 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0034 0.0034
Echinococcus multilocularis dna polymerase eta 0.002 0.0022 0.0022
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0015 0.0007 0.0007
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0015 0.0007 0.0007
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0015 0.0007 0.0007
Echinococcus granulosus biogenic amine 5HT receptor 0.0015 0.0007 0.0007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0015 0.0007 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.0345 0.0345
Schistosoma mansoni histamine h1 receptor 0.0015 0.0007 0.0007
Mycobacterium tuberculosis Possible penicillin-binding protein 0.047 0.1178 1
Brugia malayi hypothetical protein 0.0157 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.0074 0.0159 0.0159
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0716 0.5826
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0076 0.333
Onchocerca volvulus 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0059 0.0074
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0007 0.0007
Loa Loa (eye worm) G-protein coupled receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0121 0.0981
Echinococcus multilocularis serotonin transporter 0.0147 0.0346 0.0346
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0025 0.0034 0.0033
Echinococcus multilocularis vesicular acetylcholine transporter 0.3906 1 1
Brugia malayi neuropeptide F receptor 0.0015 0.0007 0.0007
Toxoplasma gondii NADPH-glutathione reductase 0.0035 0.0059 0.2586
Brugia malayi Tachykinin-like peptides receptor 99D 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0015 0.0007 0.0007
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 0.0716 0.8723
Schistosoma mansoni hypothetical protein 0.0015 0.0007 0.0007
Plasmodium falciparum thioredoxin reductase 0.01 0.0227 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0035 0.0059 0.2586
Echinococcus granulosus tachykinin peptides receptor 99D 0.0015 0.0007 0.0007
Echinococcus granulosus peptide allatostatin:somatostatin 0.0015 0.0007 0.0007
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0076 0.0614
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0015 0.0007 0.0007
Brugia malayi Pre-SET motif family protein 0.0431 0.1076 0.1076
Giardia lamblia PHD finger protein 15 0.0029 0.0044 0.0536
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0015 0.0007 0.0007
Schistosoma mansoni amine GPCR 0.0015 0.0007 0.0007
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0162 0.0162
Schistosoma mansoni hypothetical protein 0.0029 0.0044 0.0044
Entamoeba histolytica glycogen phosphorylase, putative 0.0331 0.0821 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0254 0.0622 0.5278
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0025 0.0034 0.0033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.0345 0.0345
Echinococcus multilocularis G-protein coupled receptor, putative 0.0015 0.0007 0.0007
Trypanosoma brucei C-8 sterol isomerase, putative 0.3074 0.7865 1
Schistosoma mansoni neuropeptide F-like receptor 0.0015 0.0007 0.0007
Plasmodium falciparum phd finger protein, putative 0.0029 0.0044 0.194
Brugia malayi putative neuropeptide receptor 0.0015 0.0007 0.0007
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0034 0.0034
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0716 0.5826
Echinococcus granulosus dro:myosuppressin receptor 0.0015 0.0007 0.0007
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0044 0.0044
Echinococcus multilocularis allatostatin A receptor 0.0015 0.0007 0.0007
Brugia malayi G-protein coupled receptor 0.0015 0.0007 0.0007
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.006 0.006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.0345 0.0345
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0022 0.0022
Echinococcus granulosus glycogen phosphorylase 0.0331 0.0821 0.0821
Echinococcus granulosus neuropeptides capa receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0046 0.0045
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0035 0.0059 0.0583
Schistosoma mansoni glutaminase 0.0266 0.0652 0.0652
Brugia malayi Bromodomain containing protein 0.0032 0.0053 0.0053
Brugia malayi glutaminase DH11.1 0.0266 0.0652 0.0652
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0076 0.333
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0006 0.0007
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0059 0.0074
Schistosoma mansoni alpha-1 adrenergic receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0121 0.0121
Echinococcus granulosus neuropeptide receptor 0.0015 0.0007 0.0007
Trypanosoma brucei unspecified product 0.0014 0.0006 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Schistosoma mansoni biogenic amine receptor 0.0015 0.0007 0.0007
Echinococcus granulosus neuropeptide Y receptor 0.0015 0.0007 0.0007
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0035 0.0059 0.0059
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0044 0.194
Brugia malayi hypothetical protein 0.0015 0.0007 0.0007
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0159 0.129
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0016 0.0016
Loa Loa (eye worm) melatonin receptor type 1A 0.0015 0.0007 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0015 0.0007 0.0007
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Giardia lamblia NADH oxidase lateral transfer candidate 0.0035 0.0059 0.0714
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0022 0.0022
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0015 0.0007 0.0007
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0034 0.1474
Echinococcus granulosus alpha 1A adrenergic receptor 0.0015 0.0007 0.0007
Brugia malayi putative neuropeptide receptor NPR1 0.0015 0.0007 0.0007
Trypanosoma cruzi trypanothione reductase, putative 0.01 0.0227 0.0288
Schistosoma mansoni neuropeptide receptor 0.0015 0.0007 0.0007
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0121 0.0981
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0007 0.0007
Echinococcus granulosus hypothetical protein 0.0015 0.0007 0.0007
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0035 0.0059 0.2586
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0059 0.0074
Loa Loa (eye worm) hypothetical protein 0.0147 0.0346 0.0346
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0159 0.129
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Echinococcus multilocularis geminin 0.0525 0.1319 0.1319
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0159 0.0202
Echinococcus multilocularis sodium and chloride dependent glycine 0.0025 0.0034 0.0033
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0015 0.0007 0.0007
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0015 0.0007 0.0007
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.032 0.032
Echinococcus granulosus sodium and chloride dependent glycine 0.0025 0.0034 0.0033
Brugia malayi Abnormal catecholamine distribution protein 1 0.0187 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0033
Echinococcus granulosus orexin receptor type 2 0.0015 0.0007 0.0007
Echinococcus multilocularis g protein coupled receptor 0.0015 0.0007 0.0007
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0101 0.0101
Echinococcus granulosus allatostatin A receptor 0.0015 0.0007 0.0007
Schistosoma mansoni ap endonuclease 0.0059 0.0121 0.0121
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0121 0.5321
Echinococcus granulosus glycogen phosphorylase 0.0331 0.0821 0.0821
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0033
Schistosoma mansoni neuropeptide receptor 0.0015 0.0007 0.0007
Schistosoma mansoni amine GPCR 0.0015 0.0007 0.0007
Schistosoma mansoni biogenic amine receptor 0.0015 0.0007 0.0007
Echinococcus granulosus neuropeptides capa receptor 0.0015 0.0007 0.0007
Treponema pallidum fructose-bisphosphate aldolase 0.0291 0.0716 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Brugia malayi neuropeptide F receptor 0.0015 0.0007 0.0007
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0159 0.1347
Echinococcus granulosus synaptic vesicular amine transporter 0.0187 0.0451 0.045
Onchocerca volvulus 0.0025 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.005 0.0097 0.0097
Loa Loa (eye worm) glutathione reductase 0.01 0.0227 0.0227
Echinococcus multilocularis sex peptide receptor 0.0015 0.0007 0.0007
Trichomonas vaginalis set domain proteins, putative 0.049 0.1229 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0044 0.0044
Brugia malayi hypothetical protein 0.0075 0.0162 0.0162
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0228 0.0556 0.8586
Onchocerca volvulus 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0147 0.0346 0.0346
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0159 0.129
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0143 0.0338 0.2867
Loa Loa (eye worm) hypothetical protein 0.0074 0.0159 0.0159
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0015 0.0007 0.0007
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0022 0.0028
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0073 0.0073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0022 0.0022
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0034 0.0034
Brugia malayi PHD-finger family protein 0.0029 0.0044 0.0044
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0076 0.0614
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0044 0.0044
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0147 0.0346 0.0346
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0015 0.0007 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0059 0.0074
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0035 0.0059 0.0583
Schistosoma mansoni survival motor neuron protein 0.0051 0.0101 0.0101
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0157 0.0374 0.0374
Schistosoma mansoni biogenic amine receptor 0.0015 0.0007 0.0007
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0034 0.1474
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0034 0.0034
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0159 0.1347
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0034 0.0034
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0716 0.5826
Onchocerca volvulus Glycogen phosphorylase homolog 0.0331 0.0821 0.0821
Loa Loa (eye worm) TYRA-2 protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0015 0.0007 0.0007
Schistosoma mansoni glycogen phosphorylase 0.0331 0.0821 0.0821
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0159 0.217
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0015 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0015 0.0007 0.0007
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0121 0.0153
Loa Loa (eye worm) hypothetical protein 0.025 0.0611 0.0611
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.3906 1 1
Onchocerca volvulus 0.0015 0.0007 0.0007
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0035 0.0059 0.2586
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0059 0.0074
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0121 0.1469
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0716 0.5826
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0025 0.0034 0.0033
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0022 0.0028
Onchocerca volvulus 0.0015 0.0007 0.0007
Echinococcus granulosus dna polymerase eta 0.002 0.0022 0.0022
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0121 0.1024
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0044 0.194
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0716 0.5826
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0028
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0162 0.0162
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0716 0.5826
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Plasmodium vivax thioredoxin reductase, putative 0.01 0.0227 1
Brugia malayi G-protein coupled receptor 0.0015 0.0007 0.0007
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0022 0.0028
Echinococcus granulosus tm gpcr rhodopsin 0.0015 0.0007 0.0007
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.01 0.0227 0.1925
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0015 0.0007 0.0007
Brugia malayi beta-lactamase 0.0074 0.0159 0.0159
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0034 0.0034
Trichomonas vaginalis esterase, putative 0.0074 0.0159 0.129
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0129 0.0129
Schistosoma mansoni amine GPCR 0.0015 0.0007 0.0007
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0123 0.0122
Loa Loa (eye worm) glutaminase 0.0266 0.0652 0.0652
Loa Loa (eye worm) thioredoxin reductase 0.01 0.0227 0.0227
Schistosoma mansoni biogenic amine (5HT) receptor 0.0015 0.0007 0.0007
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0025 0.0034 0.0034
Brugia malayi hypothetical protein 0.0015 0.0007 0.0007
Brugia malayi AKH receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0033
Brugia malayi hypothetical protein 0.0015 0.0007 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0007 0.0007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0059 0.0074
Echinococcus multilocularis synaptic vesicular amine transporter 0.0187 0.0451 0.045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0007 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0159 0.6997
Schistosoma mansoni hypothetical protein 0.0015 0.0007 0.0007
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0022 0.0178
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0033
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0034 0.0034
Echinococcus granulosus dna polymerase kappa 0.002 0.0022 0.0022
Brugia malayi carbohydrate phosphorylase 0.0331 0.0821 0.0821
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.0611 0.0611
Brugia malayi RE15519p 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0147 0.0346 0.0346
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0022 0.0028
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0001 0.0005
Loa Loa (eye worm) G-protein coupled receptor 0.0015 0.0007 0.0007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0121 0.0153
Schistosoma mansoni amine GPCR 0.0015 0.0007 0.0007
Echinococcus multilocularis fmrfamide receptor 0.0015 0.0007 0.0007
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) neuropeptide F receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0074 0.0159 0.0159
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0025 0.0034 0.0033
Mycobacterium tuberculosis Conserved protein 0.0074 0.0159 0.1347
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0009 0.0382
Schistosoma mansoni vesicular acetylcholine transporter 0.3906 1 1
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0028 0.0028
Brugia malayi Serotonin receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0146 0.0345 0.0345
Echinococcus multilocularis Glycosyl transferase, family 35 0.0331 0.0821 0.0821
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0025 0.0034 0.0033
Brugia malayi Pre-SET motif family protein 0.0062 0.0129 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0028
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0001 0.0004
Plasmodium vivax SET domain protein, putative 0.0062 0.0129 0.5658
Brugia malayi Serotonin receptor 0.0015 0.0007 0.0007
Schistosoma mansoni sodium-dependent amino acid transporter 0.0025 0.0034 0.0034
Mycobacterium tuberculosis Probable oxidoreductase 0.0254 0.0622 0.5278
Trypanosoma brucei unspecified product 0.0014 0.0006 0.0007
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0015 0.0007 0.0007
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0025 0.0034 0.0033
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0129 0.5658
Echinococcus granulosus geminin 0.0525 0.1319 0.1319
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0121 0.0153
Brugia malayi jmjC domain containing protein 0.0095 0.0214 0.0214
Echinococcus multilocularis neuropeptide receptor 0.0015 0.0007 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0159 0.129
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0159 0.0159
Entamoeba histolytica hypothetical protein 0.0075 0.0162 0.1973
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0345 0.0345
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0028
Brugia malayi hypothetical protein 0.0015 0.0007 0.0007
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0025 0.0034 0.0033
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0059 0.0074
Schistosoma mansoni glycogen phosphorylase 0.0143 0.0338 0.0338
Onchocerca volvulus Alhambra homolog 0.0029 0.0044 0.0044
Plasmodium falciparum glutathione reductase 0.01 0.0227 1
Brugia malayi hypothetical protein 0.0015 0.0007 0.0007
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0147 0.0346 0.0346
Echinococcus multilocularis neuropeptide Y receptor 0.0015 0.0007 0.0007
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0022 0.0186
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.006 0.006
Brugia malayi Dopamine receptor protein 2 0.0015 0.0007 0.0007
Brugia malayi ORL1-like opioid receptor 0.0015 0.0007 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0034 0.1474
Loa Loa (eye worm) glycogen phosphorylase 0.0331 0.0821 0.0821
Onchocerca volvulus 0.0147 0.0346 0.0346
Echinococcus granulosus somatostatin receptor 0.0015 0.0007 0.0007
Echinococcus multilocularis fmrfamide receptor 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0015 0.0007 0.0007
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0121 0.1469
Echinococcus granulosus biogenic amine 5HT receptor 0.0015 0.0007 0.0007
Echinococcus multilocularis glycogen phosphorylase 0.0331 0.0821 0.0821
Loa Loa (eye worm) glutaminase 2 0.0266 0.0652 0.0652
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0015 0.0007 0.0007
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0015 0.0007 0.0007
Echinococcus granulosus thioredoxin glutathione reductase 0.01 0.0227 0.0227
Echinococcus multilocularis g protein coupled receptor 0.0015 0.0007 0.0007
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0121 0.0121
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0015 0.0007 0.0007
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0159 0.1347
Schistosoma mansoni DNA polymerase eta 0.002 0.0022 0.0022
Echinococcus granulosus 7TM GPCR rhodopsin 0.0015 0.0007 0.0007
Trypanosoma cruzi C-8 sterol isomerase, putative 0.3074 0.7865 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0129 0.0128
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0228 0.0556 0.4722
Brugia malayi jmjC domain containing protein 0.0035 0.006 0.006
Schistosoma mansoni ap endonuclease 0.0059 0.0121 0.0121
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.3074 0.7865 0.7865
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0007 0.0007
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0015 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.0075 0.0162 0.1973
Echinococcus multilocularis glycogen phosphorylase 0.0331 0.0821 0.0821
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0121 0.0121
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0035 0.0059 0.0074
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0035 0.0059 0.0583
Onchocerca volvulus 0.0015 0.0007 0.0007
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0001 0.0001
Onchocerca volvulus 0.0015 0.0007 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0007 0.0007
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0001 0.0001
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0214 0.0213
Schistosoma mansoni opsin-like receptor 0.0015 0.0007 0.0007
Mycobacterium ulcerans glutaminase 0.0266 0.0652 1
Brugia malayi beta-lactamase family protein 0.0074 0.0159 0.0159
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0028
Entamoeba histolytica glycogen phosphorylase, putative 0.0331 0.0821 1
Brugia malayi hypothetical protein 0.025 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0074 0.0159 0.0159
Schistosoma mansoni hypothetical protein 0.0015 0.0007 0.0007
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0015 0.0007 0.0007
Echinococcus multilocularis serotonin receptor 0.0015 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Toxoplasma gondii exonuclease III APE 0.0059 0.0121 0.5321
Echinococcus granulosus tm gpcr rhodopsin 0.056 0.1408 0.1408
Entamoeba histolytica glycogen phosphorylase, putative 0.0143 0.0338 0.4113
Echinococcus multilocularis dro:myosuppressin receptor 0.0015 0.0007 0.0007
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0015 0.0007 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0007 0.0007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0146 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Echinococcus granulosus fmrfamide receptor 0.0015 0.0007 0.0007
Echinococcus multilocularis neuropeptide receptor A26 0.0015 0.0007 0.0007
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0076 0.333
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0431 0.1076 0.1076
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0009 0.0361
Echinococcus multilocularis dna polymerase kappa 0.002 0.0022 0.0022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0022 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0028
Loa Loa (eye worm) hypothetical protein 0.0074 0.0159 0.0159
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0015 0.0007 0.0007
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0035 0.0059 0.0059
Brugia malayi sulfakinin receptor protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.1571 0.4005 0.4005
Plasmodium falciparum transporter, putative 0.0025 0.0034 0.1474
Schistosoma mansoni neuropeptide receptor 0.0015 0.0007 0.0007
Trichomonas vaginalis glycogen phosphorylase, putative 0.0331 0.0821 0.6679
Schistosoma mansoni sodium/chloride dependent transporter 0.0025 0.0034 0.0034
Trichomonas vaginalis glutaminase, putative 0.0266 0.0652 0.5303
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0015 0.0007 0.0007
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0035 0.0059 0.0059
Brugia malayi hypothetical protein 0.0015 0.0007 0.0007
Plasmodium vivax amine transporter, putative 0.0025 0.0034 0.1474
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0129 0.0128
Brugia malayi hypothetical protein 0.0015 0.0007 0.0007
Brugia malayi ERG2 and Sigma1 receptor like protein 0.3074 0.7865 0.7865
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0124 0.0123
Leishmania major DNA polymerase kappa, putative 0.002 0.0022 0.0028
Leishmania major C-8 sterol isomerase-like protein 0.3074 0.7865 1
Echinococcus multilocularis serotonin receptor 0.0015 0.0007 0.0007
Schistosoma mansoni glycogen phosphorylase 0.0331 0.0821 0.0821
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0025 0.0034 0.0034
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0035 0.0059 0.0074
Brugia malayi hypothetical protein 0.0025 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.0121 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0059 0.0074
Trypanosoma brucei unspecified product 0.002 0.0022 0.0028
Echinococcus granulosus tm gpcr rhodopsin 0.0015 0.0007 0.0007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0059 0.0074
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0121 0.1567
Echinococcus multilocularis thioredoxin glutathione reductase 0.01 0.0227 0.0227
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0001 0.0001
Brugia malayi beta-lactamase family protein 0.0074 0.0159 0.0159
Echinococcus granulosus g-protein coupled receptor 0.0015 0.0007 0.0007
Schistosoma mansoni neuropeptide F-like receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) neuropeptide F receptor 0.0015 0.0007 0.0007
Brugia malayi Dopamine receptor 0.0015 0.0007 0.0007
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0025 0.0034 0.0033
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0034 0.0034
Leishmania major DNA polymerase eta, putative 0.002 0.0022 0.0028
Schistosoma mansoni neuropeptide f receptor 76f 0.0015 0.0007 0.0007
Echinococcus granulosus vesicular acetylcholine transporter 0.3906 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0015 0.0007 0.0007
Schistosoma mansoni vesicular amine transporter 0.0187 0.0451 0.0451
Trichomonas vaginalis glutathione reductase, putative 0.0035 0.0059 0.0477
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0015 0.0007 0.0007
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0076 0.0075
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0159 0.1347
Entamoeba histolytica hypothetical protein 0.0075 0.0162 0.1973
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0059 0.0074
Mycobacterium tuberculosis Probable dehydrogenase 0.0228 0.0556 0.4722
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.0007 0.0007
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0059 0.0074
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0121 0.0153
Echinococcus granulosus neuropeptide s receptor 0.0015 0.0007 0.0007
Mycobacterium ulcerans beta-lactamase 0.0074 0.0159 0.217
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0159 0.129
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Toxoplasma gondii hypothetical protein 0.0025 0.0034 0.1474
Echinococcus granulosus neuropeptide receptor 0.0015 0.0007 0.0007
Giardia lamblia DINP protein human, muc B family 0.002 0.0022 0.0266
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0022 0.0022
Brugia malayi larval opioid receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0062 0.0129 0.0128
Echinococcus granulosus g protein coupled receptor 0.0015 0.0007 0.0007
Treponema pallidum NADH oxidase 0.0035 0.0059 0.0818
Leishmania major trypanothione reductase 0.01 0.0227 0.0288
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0159 0.0202
Schistosoma mansoni sodium/chloride dependent transporter 0.0147 0.0346 0.0346
Echinococcus granulosus neuropeptide receptor A26 0.0015 0.0007 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0067 0.0812
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0254 0.0622 0.5278
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0025 0.0034 0.0034
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.0334 0.4958
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0035 0.0059 0.0059
Onchocerca volvulus 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0033
Echinococcus granulosus serotonin receptor 0.0015 0.0007 0.0007
Schistosoma mansoni neuropeptide receptor 0.0015 0.0007 0.0007
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0228 0.0556 0.4722
Schistosoma mansoni biogenic amine (5HT) receptor 0.0015 0.0007 0.0007
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0228 0.0556 0.4722
Mycobacterium tuberculosis Conserved protein 0.0074 0.0159 0.1347
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.0334 0.2838
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0022 0.0022
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0121 0.5321
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0214 0.0213
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0034 0.0034
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 0.0716 0.8723
Loa Loa (eye worm) acetyltransferase 0.014 0.033 0.033
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0035 0.0059 0.0074
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Brugia malayi G protein-coupled receptor F59B2.13 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0157 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0028 0.0223
Schistosoma mansoni growth hormone secretagogue receptor 0.0015 0.0007 0.0007
Entamoeba histolytica glycogen phosphorylase, putative 0.0143 0.0338 0.4113
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Trichomonas vaginalis mercuric reductase, putative 0.0035 0.0059 0.0477
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0254 0.0622 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Trichomonas vaginalis glycogen phosphorylase, putative 0.0331 0.0821 0.6679
Echinococcus granulosus serotonin transporter 0.0147 0.0346 0.0346
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0022 0.0028
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0159 0.1347
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.3906 1 1
Brugia malayi G protein-coupled receptor 0.0015 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0028
Brugia malayi Dopamine receptor protein 1 0.0015 0.0007 0.0007
Mycobacterium ulcerans lipase LipD 0.0074 0.0159 0.217
Echinococcus granulosus jumonji domain containing protein 0.004 0.0073 0.0073
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0035 0.0059 0.0074
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Plasmodium vivax glutathione reductase, putative 0.01 0.0227 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0028 0.0223
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0015 0.0007 0.0007
Echinococcus multilocularis g protein coupled receptor 0.0015 0.0007 0.0007
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0121 0.0121
Brugia malayi Thioredoxin reductase 0.01 0.0227 0.0227
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0025 0.0034 0.0033
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0022 0.0028
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0015 0.0007 0.0007
Echinococcus granulosus bloom syndrome protein 0.0023 0.0028 0.0027
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0228 0.0556 0.4722
Brugia malayi hypothetical protein 0.0015 0.0007 0.0007
Plasmodium falciparum glutathione reductase 0.0035 0.0059 0.2586
Loa Loa (eye worm) solute carrier family 6 member 4 0.0147 0.0346 0.0346
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0044 0.194
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0015 0.0007 0.0007
Schistosoma mansoni myosin xvIII 0.0015 0.0007 0.0007
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0015 0.0007 0.0007
Echinococcus multilocularis somatostatin receptor 0.0015 0.0007 0.0007
Entamoeba histolytica glycogenphosphorylase, putative 0.0143 0.0338 0.4113
Brugia malayi Melatonin receptor type 1A 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0015 0.0007 0.0007
Schistosoma mansoni opsin-like receptor 0.0015 0.0007 0.0007
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0022 0.0266
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0015 0.0007 0.0007
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0015 0.0007 0.0007
Toxoplasma gondii ABC1 family protein 0.0074 0.0159 0.6997
Schistosoma mansoni hypothetical protein 0.0051 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Echinococcus multilocularis orexin receptor type 2 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0074 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Onchocerca volvulus 0.0074 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0022 0.0178
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0028 0.0027
Loa Loa (eye worm) norepinephrine transporter 0.0147 0.0346 0.0346
Onchocerca volvulus 0.0062 0.0129 0.0128
Onchocerca volvulus 0.049 0.1229 0.1229
Schistosoma mansoni hypothetical protein 0.0525 0.1319 0.1319
Schistosoma mansoni hypothetical protein 0.0075 0.0162 0.0162
Brugia malayi hypothetical protein 0.0015 0.0007 0.0007
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0162 0.0162
Echinococcus multilocularis g-protein coupled receptor 0.0015 0.0007 0.0007
Toxoplasma gondii hypothetical protein 0.0025 0.0034 0.1474
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.006 0.006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0159 0.0159
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0159 0.1347
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0006 0.0007
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0035 0.0059 0.2586
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0258 0.0632 0.0631
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Plasmodium falciparum amino acid transporter, putative 0.0025 0.0034 0.1474
Onchocerca volvulus 0.0015 0.0007 0.0007
Brugia malayi follicle stimulating hormone receptor 0.0258 0.0632 0.0632
Leishmania major hypothetical protein, conserved 0.0074 0.0159 0.0202
Loa Loa (eye worm) serotonin transporter b 0.0147 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Echinococcus multilocularis neuropeptide s receptor 0.0015 0.0007 0.0007
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0035 0.0035
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0716 0.5826
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0345 0.0345
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0035 0.0059 0.032
Echinococcus granulosus peregrin 0.0032 0.0053 0.0053
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0022 0.0186
Echinococcus granulosus sex peptide receptor 0.0015 0.0007 0.0007
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0025 0.0034 0.0033
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.006 0.006
Echinococcus granulosus sodium and chloride dependent glycine 0.0025 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0074 0.0159 0.0159
Echinococcus multilocularis peregrin 0.0032 0.0053 0.0053
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0022 0.0022
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0015 0.0007 0.0007
Giardia lamblia Glycogen phosphorylase 0.0331 0.0821 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0716 0.5826
Brugia malayi glutathione reductase 0.01 0.0227 0.0227
Echinococcus multilocularis neuropeptides capa receptor 0.0015 0.0007 0.0007
Echinococcus granulosus neuropeptide FF receptor 2 0.0015 0.0007 0.0007
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0035 0.0059 0.2586
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Chlamydia trachomatis glycogen phosphorylase 0.0331 0.0821 1
Schistosoma mansoni adenoreceptor 0.0015 0.0007 0.0007
Mycobacterium tuberculosis Conserved protein 0.0074 0.0159 0.1347
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.0007 0.0007
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0022 0.0028
Echinococcus granulosus g protein coupled receptor 0.0015 0.0007 0.0007
Echinococcus granulosus Glycosyl transferase family 35 0.0331 0.0821 0.0821
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.056 0.1408 0.1408
Trypanosoma brucei trypanothione reductase 0.01 0.0227 0.0288
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Treponema pallidum sodium- and chloride- dependent transporter 0.0147 0.0346 0.4832
Echinococcus multilocularis G protein coupled receptor 139 0.0015 0.0007 0.0007
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0015 0.0007 0.0007
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0159 0.217
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0028
Echinococcus granulosus 7tm_1 domain containing protein 0.0015 0.0007 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0129 0.0129
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0129 0.0128
Onchocerca volvulus Neuropeptide F receptor homolog 0.0015 0.0007 0.0007
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0022 0.0028
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0015 0.0007 0.0007
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.0187 0.0451 0.045

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.06 uM Binding affinity against human IMR 90 fetal lung fibroblast bradykinin receptor B2 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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