Detailed information for compound 209912

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 415.913 | Formula: C21H20ClN2O3S-
  • H donors: 1 H acceptors: 2 LogP: 4.46 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)Cc1scc(n1)c1ccc2c(c1)CCC(=O)N2.[Cl-]
  • InChi: 1S/C21H20N2O3S.ClH/c1-25-18-7-3-13(9-19(18)26-2)10-21-23-17(12-27-21)15-4-6-16-14(11-15)5-8-20(24)22-16;/h3-4,6-7,9,11-12H,5,8,10H2,1-2H3,(H,22,24);1H/p-1
  • InChiKey: XFBGRNZFYHDDDO-UHFFFAOYSA-M  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0007 0.0666
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0019 0.0009 0.0002
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0027 0.002 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0349 0.9528
Schistosoma mansoni neuropeptide receptor 0.0019 0.0009 0.0002
Echinococcus multilocularis sex peptide receptor 0.0019 0.0009 0.0002
Echinococcus granulosus G protein coupled receptor 139 0.0019 0.0009 0.0002
Schistosoma mansoni alpha-1 adrenergic receptor 0.0019 0.0009 0.0002
Schistosoma mansoni neuropeptide receptor 0.0019 0.0009 0.0002
Brugia malayi hypothetical protein 0.0019 0.0009 0.0009
Schistosoma mansoni amine GPCR 0.0019 0.0009 0.0002
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0011 0.0249
Echinococcus multilocularis beta galactosidase 0.0136 0.0177 0.017
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0011 0.0679
Mycobacterium tuberculosis Probable dehydrogenase 0.0121 0.0156 0.8837
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0027 0.002 0.002
Schistosoma mansoni biogenic amine receptor 0.0019 0.0009 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0261 0.0359 0.0352
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0009 0.0001
Schistosoma mansoni opsin-like receptor 0.0019 0.0009 0.0002
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0009 0.0002
Echinococcus granulosus dro:myosuppressin receptor 0.0019 0.0009 0.0002
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.0222 0.0214
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0009 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0222 0.5996
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0011 0.0073
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0009 0.0002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0009 0.0002
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.5868 0.8495 0.8494
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0029 0.0022
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0012
Echinococcus granulosus g-protein coupled receptor 0.0019 0.0009 0.0002
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0011 0.0059
Echinococcus granulosus neuropeptide receptor A26 0.0019 0.0009 0.0002
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0027 0.002 0.0012
Brugia malayi hypothetical protein 0.0019 0.0009 0.0009
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.002 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0011 0.0011
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0057 0.2985
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0015 0.0208
Schistosoma mansoni opsin-like receptor 0.0019 0.0009 0.0002
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0041 0.0041 0.6654
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0019 0.0009 0.0002
Echinococcus granulosus g protein coupled receptor 0.0019 0.0009 0.0002
Echinococcus granulosus 7TM GPCR rhodopsin 0.0019 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0057 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0019 0.0009 0.0009
Onchocerca volvulus 0.0027 0.002 0.0011
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0027 0.002 0.0012
Trypanosoma brucei trypanothione reductase 0.0053 0.0057 0.0066
Schistosoma mansoni DNA polymerase eta 0.0021 0.0011 0.0004
Echinococcus granulosus neuropeptide receptor 0.0019 0.0009 0.0002
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0019 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0009 0.0002
Schistosoma mansoni neuropeptide receptor 0.0019 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Trypanosoma cruzi sterol C-24 reductase, putative 0.0048 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0034 0.0029 0.0021
Brugia malayi Tachykinin-like peptides receptor 99D 0.0019 0.0009 0.0009
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0019 0.0009 0.0002
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Schistosoma mansoni neuropeptide f receptor 76f 0.0019 0.0009 0.0002
Brugia malayi Serotonin receptor 0.0019 0.0009 0.0009
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0009 0.0002
Leishmania major C-14 sterol reductase, putative 0.0092 0.0113 0.0125
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0027 0.002 0.0012
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0009 0.0002
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0254 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0222 0.5996
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0011 0.0095
Echinococcus multilocularis synaptic vesicular amine transporter 0.0192 0.0259 0.0252
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0027 0.002 0.0012
Schistosoma mansoni hypothetical protein 0.0019 0.0009 0.0002
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0009 0.0002
Echinococcus granulosus serotonin transporter 0.0159 0.0211 0.0204
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0009 0.0002
Brugia malayi Dopamine receptor 0.0019 0.0009 0.0009
Trypanosoma cruzi C-14 sterol reductase, putative 0.0092 0.0113 0.0125
Brugia malayi Dopamine receptor protein 1 0.0019 0.0009 0.0009
Echinococcus granulosus vesicular acetylcholine transporter 0.6906 1 1
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0011 0.0011
Echinococcus granulosus neuropeptide FF receptor 2 0.0019 0.0009 0.0002
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0029 0.0022
Brugia malayi hypothetical protein 0.0019 0.0009 0.0009
Brugia malayi G-protein coupled receptor 0.0019 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Echinococcus granulosus tm gpcr rhodopsin 0.111 0.1592 0.1586
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0011 0.0005
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.0192 0.0259 0.0252
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0007 0.0007
Brugia malayi glutathione reductase 0.0053 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0136 0.0177 0.017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0012
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0058 0.0058
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0159 0.0211 0.0204
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0011 0.0004
Leishmania major DNA polymerase eta, putative 0.0021 0.0011 0.0005
Echinococcus multilocularis fucosidase, alpha L 1, tissue 0.0415 0.0583 0.0576
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0011 0.0117
Trypanosoma brucei C-8 sterol isomerase, putative 0.5868 0.8495 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0027 0.002 0.0012
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0009 0.0002
Echinococcus granulosus 7tm_1 domain containing protein 0.0019 0.0009 0.0002
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0029 0.4761
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0011 0.0011
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0057 0.005
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0349 0.9528
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0121 0.0156 0.8837
Schistosoma mansoni survival motor neuron protein 0.0053 0.0058 0.0051
Schistosoma mansoni hypothetical protein 0.0377 0.0528 0.0521
Echinococcus multilocularis sodium and chloride dependent glycine 0.0027 0.002 0.0012
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0009 0.0002
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0009 0.0002
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0027 0.002 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0222 0.5996
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0019 0.0009 0.0009
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0009 0.0002
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0009 0.0001
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0009 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0009 0.0002
Schistosoma mansoni amine GPCR 0.0019 0.0009 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0349 0.9528
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0009 0.0002
Brugia malayi RE15519p 0.0019 0.0009 0.0009
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0222 0.5996
Loa Loa (eye worm) hypothetical protein 0.2999 0.4332 0.4328
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0009 0.0002
Loa Loa (eye worm) solute carrier family 6 member 4 0.0159 0.0211 0.0204
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0004
Trypanosoma cruzi C-8 sterol isomerase, putative 0.5868 0.8495 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0011 0.0117
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Loa Loa (eye worm) TYRA-2 protein 0.0019 0.0009 0.0001
Echinococcus granulosus serotonin receptor 0.0019 0.0009 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0349 0.9528
Echinococcus multilocularis neuropeptide receptor A26 0.0019 0.0009 0.0002
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0009 0.0002
Leishmania major C-8 sterol isomerase-like protein 0.5868 0.8495 1
Echinococcus granulosus allatostatin A receptor 0.0019 0.0009 0.0002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0011 0.0004
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0009 0.0002
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0273 0.0377 0.037
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0011 0.0011
Brugia malayi hypothetical protein 0.0261 0.0359 0.0359
Schistosoma mansoni sodium/chloride dependent transporter 0.0159 0.0211 0.0204
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.002 0.0012
Echinococcus multilocularis G protein coupled receptor 139 0.0019 0.0009 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0009 0.0002
Echinococcus granulosus synaptic vesicular amine transporter 0.0192 0.0259 0.0252
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0019 0.0009 0.0002
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0007 0.0006
Brugia malayi Melatonin receptor type 1A 0.0019 0.0009 0.0009
Brugia malayi Thioredoxin reductase 0.0053 0.0057 0.0057
Echinococcus multilocularis g-protein coupled receptor 0.0019 0.0009 0.0002
Brugia malayi ERG2 and Sigma1 receptor like protein 0.5868 0.8495 0.8495
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0009 0.0002
Leishmania major trypanothione reductase 0.0053 0.0057 0.0059
Loa Loa (eye worm) alpha-L-fucosidase 0.0251 0.0345 0.0337
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0011 0.0011
Plasmodium vivax glutathione reductase, putative 0.0053 0.0057 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0019 0.0009 0.0002
Brugia malayi hypothetical protein 0.0019 0.0009 0.0009
Echinococcus granulosus tachykinin peptides receptor 99D 0.0019 0.0009 0.0002
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0007 0.0666
Echinococcus granulosus g protein coupled receptor 0.0019 0.0009 0.0002
Brugia malayi follicle stimulating hormone receptor 0.0273 0.0377 0.0377
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0019 0.0009 0.0002
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0019 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Brugia malayi hypothetical protein 0.0019 0.0009 0.0009
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.002 0.3011
Onchocerca volvulus 0.0027 0.002 0.0011
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0019 0.0009 0.0002
Schistosoma mansoni sodium-dependent amino acid transporter 0.0027 0.002 0.0012
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0041 0.6877
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0009 0.0002
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0019 0.0009 0.0001
Mycobacterium ulcerans alpha-L-fucosidase 0.0415 0.0583 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0015 0.0208
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0011 0.0005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0011 0.0168
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0121 0.0156 0.8837
Echinococcus granulosus beta galactosidase 0.0136 0.0177 0.017
Echinococcus granulosus sex peptide receptor 0.0019 0.0009 0.0002
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0019 0.0009 0.0002
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0019 0.0009 0.0002
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0011 0.0004
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0019 0.0009 0.0001
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0254 0.0349 0.0342
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0011 0.0203
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0011 0.0095
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0011 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0009 0.0002
Brugia malayi GnHR receptor homolog 0.0019 0.0009 0.0009
Giardia lamblia DINP protein human, muc B family 0.0021 0.0011 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Echinococcus granulosus neuropeptide receptor 0.0019 0.0009 0.0002
Brugia malayi putative neuropeptide receptor 0.0019 0.0009 0.0009
Brugia malayi G-protein coupled receptor 0.0019 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0019 0.0009 0.0002
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.002 0.3011
Toxoplasma gondii exonuclease III APE 0.0021 0.0011 0.1344
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.002 0.002
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0011 0.0003
Onchocerca volvulus 0.0034 0.0029 0.002
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0009 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0011 0.0011
Schistosoma mansoni amine GPCR 0.0019 0.0009 0.0002
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0009 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0009 0.0002
Echinococcus multilocularis allatostatin A receptor 0.0019 0.0009 0.0002
Brugia malayi larval opioid receptor 0.0019 0.0009 0.0009
Brugia malayi hypothetical protein 0.0019 0.0009 0.0009
Brugia malayi neuropeptide F receptor 0.0019 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Trichomonas vaginalis alpha-L-fucosidase, putative 0.011 0.014 0.3704
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0011 0.0003
Plasmodium falciparum amino acid transporter, putative 0.0027 0.002 0.2474
Brugia malayi sulfakinin receptor protein 0.0019 0.0009 0.0009
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0019 0.0009 0.0009
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0029 0.0022
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0135 0.0176 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0011 0.0005
Echinococcus multilocularis vesicular acetylcholine transporter 0.6906 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0057 0.0059
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Loa Loa (eye worm) norepinephrine transporter 0.0159 0.0211 0.0204
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Toxoplasma gondii thioredoxin reductase 0.0053 0.0057 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Schistosoma mansoni vesicular amine transporter 0.0192 0.0259 0.0252
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0012
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0048 0.005 0.0042
Schistosoma mansoni amine GPCR 0.0019 0.0009 0.0002
Onchocerca volvulus 0.0053 0.0058 0.0049
Mycobacterium tuberculosis Probable reductase 0.0121 0.0156 0.8837
Plasmodium falciparum transporter, putative 0.0027 0.002 0.2474
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0009 0.0002
Plasmodium falciparum glutathione reductase 0.0053 0.0057 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0027 0.002 0.0012
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0057 0.005
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0349 0.9528
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0027 0.002 0.0012
Schistosoma mansoni biogenic amine receptor 0.0019 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0159 0.0211 0.0204
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Brugia malayi hypothetical protein 0.0019 0.0009 0.0009
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0015 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0029 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0222 0.5996
Trypanosoma brucei C-14 sterol reductase, putative 0.0092 0.0113 0.0132
Trypanosoma cruzi sterol C-24 reductase, putative 0.0048 0.005 0.005
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0019 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Treponema pallidum sodium- and chloride- dependent transporter 0.0159 0.0211 1
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0009 0.0002
Schistosoma mansoni ap endonuclease 0.0021 0.0011 0.0003
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0027 0.002
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0009 0.0002
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0136 0.0177 0.017
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0135 0.0176 1
Toxoplasma gondii hypothetical protein 0.0027 0.002 0.3011
Brugia malayi Dopamine receptor protein 2 0.0019 0.0009 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0011 0.0011
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0011 1
Echinococcus granulosus neuropeptide s receptor 0.0019 0.0009 0.0002
Echinococcus multilocularis serotonin receptor 0.0019 0.0009 0.0002
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.002 0.0012
Schistosoma mansoni hypothetical protein 0.0377 0.0528 0.0521
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.002 0.3011
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0011 1
Plasmodium falciparum thioredoxin reductase 0.0053 0.0057 1
Echinococcus multilocularis serotonin transporter 0.0159 0.0211 0.0204
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0009 0.0002
Onchocerca volvulus 0.0266 0.0366 0.0358
Brugia malayi Abnormal catecholamine distribution protein 1 0.0192 0.0259 0.0259
Schistosoma mansoni biogenic amine receptor 0.0019 0.0009 0.0002
Brugia malayi neuropeptide F receptor 0.0019 0.0009 0.0009
Echinococcus granulosus survival motor neuron protein 1 0.0261 0.0359 0.0352
Loa Loa (eye worm) RecQ helicase 0.0024 0.0015 0.0007
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0019 0.0009 0.0001
Brugia malayi hypothetical protein 0.0019 0.0009 0.0009
Loa Loa (eye worm) glutathione reductase 0.0053 0.0057 0.005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0009 0.0002
Onchocerca volvulus 0.0159 0.0211 0.0203
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0019 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Echinococcus granulosus hypothetical protein 0.0019 0.0009 0.0002
Schistosoma mansoni vesicular acetylcholine transporter 0.6906 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0011 0.0005
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.001 0.066
Echinococcus granulosus bloom syndrome protein 0.0024 0.0015 0.0007
Echinococcus multilocularis orexin receptor type 2 0.0019 0.0009 0.0002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0011 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0009 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0011 0.0011
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.002 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0236 0.6359
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0011 0.0249
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0011 0.0011
Brugia malayi AKH receptor 0.0019 0.0009 0.0009
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0009 0.0002
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0011 0.0003
Echinococcus granulosus peptide allatostatin:somatostatin 0.0019 0.0009 0.0002
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.6906 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0019 0.0009 0.0002
Echinococcus granulosus fmrfamide receptor 0.0019 0.0009 0.0002
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.002 0.002
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0009 0.0002
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0019 0.0009 0.0002
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0121 0.0156 0.8837
Schistosoma mansoni amine GPCR 0.0019 0.0009 0.0002
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0019 0.0009 0.0002
Schistosoma mansoni hypothetical protein 0.0019 0.0009 0.0002
Leishmania major DNA polymerase kappa, putative 0.0021 0.0011 0.0005
Plasmodium vivax SET domain protein, putative 0.0034 0.0029 0.4734
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0009 0.0002
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0027 0.002 1
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0011 0.0011
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0019 0.0009 0.0002
Echinococcus multilocularis neuropeptide FF receptor 2 0.0019 0.0009 0.0002
Schistosoma mansoni histamine h1 receptor 0.0019 0.0009 0.0002
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0011 0.0004
Echinococcus granulosus lamin b receptor 0.0092 0.0113 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0011 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0009 0.0002
Echinococcus multilocularis G-protein coupled receptor, putative 0.0019 0.0009 0.0002
Schistosoma mansoni beta-galactosidase 0.0136 0.0177 0.017
Brugia malayi ORL1-like opioid receptor 0.0019 0.0009 0.0009
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0019 0.0009 0.0001
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0027 0.002 0.0012
Schistosoma mansoni opsin-like receptor 0.0019 0.0009 0.0002
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0121 0.0156 0.8837
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Echinococcus granulosus sodium and chloride dependent glycine 0.0027 0.002 0.0012
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0011 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0009 0.0002
Echinococcus granulosus g protein coupled receptor 0.0019 0.0009 0.0002
Schistosoma mansoni sodium/chloride dependent transporter 0.0027 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0029 0.0022
Echinococcus multilocularis sodium and chloride dependent glycine 0.0027 0.002 0.0012
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Loa Loa (eye worm) serotonin transporter b 0.0159 0.0211 0.0204
Trichomonas vaginalis alpha-L-fucosidase, putative 0.011 0.014 0.3704
Brugia malayi Pre-SET motif family protein 0.0034 0.0029 0.0029
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0011 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0222 0.5996
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0009 0.0002
Schistosoma mansoni hypothetical protein 0.0053 0.0058 0.0051
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0222 0.5996
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Brugia malayi hypothetical protein 0.0019 0.0009 0.0009
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0135 0.0176 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0019 0.0009 0.0009
Echinococcus granulosus sodium and chloride dependent glycine 0.0027 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0019 0.0009 0.0002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0009 0.0002
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0009 0.0002
Loa Loa (eye worm) melatonin receptor type 1A 0.0019 0.0009 0.0001
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0019 0.0009 0.0002
Schistosoma mansoni myosin xvIII 0.0019 0.0009 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0009 0.0002
Schistosoma mansoni growth hormone secretagogue receptor 0.0019 0.0009 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0009 0.0002
Schistosoma mansoni sodium/chloride dependent transporter 0.0027 0.002 0.0012
Echinococcus multilocularis neuropeptide s receptor 0.0019 0.0009 0.0002
Brugia malayi Serotonin receptor 0.0019 0.0009 0.0009
Echinococcus multilocularis geminin 0.0377 0.0528 0.0521
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0011 0.0005
Echinococcus granulosus geminin 0.0377 0.0528 0.0521
Brugia malayi hypothetical protein 0.0027 0.002 0.002
Echinococcus granulosus dna polymerase eta 0.0021 0.0011 0.0004
Echinococcus multilocularis lamin b receptor 0.0092 0.0113 0.0106
Brugia malayi Pre-SET motif family protein 0.0234 0.0319 0.0319
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0012
Brugia malayi putative neuropeptide receptor NPR1 0.0019 0.0009 0.0009
Brugia malayi G protein-coupled receptor 0.0019 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Onchocerca volvulus 0.0027 0.002 0.0011
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0234 0.0319 0.0312
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0019 0.0009 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0027 0.002 0.2976
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0159 0.0211 0.0204
Brugia malayi hypothetical protein 0.0019 0.0009 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0009 0.0002
Trichomonas vaginalis set domain proteins, putative 0.0266 0.0366 1
Schistosoma mansoni adenoreceptor 0.0019 0.0009 0.0002
Schistosoma mansoni ap endonuclease 0.0021 0.0011 0.0003
Toxoplasma gondii hypothetical protein 0.0027 0.002 0.3011
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0007 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0029 0.0022
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0057 0.005
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.111 0.1592 0.1586
Schistosoma mansoni alpha-l-fucosidase 0.0251 0.0345 0.0338
Schistosoma mansoni hypothetical protein 0.0019 0.0009 0.0002
Echinococcus multilocularis dro:myosuppressin receptor 0.0019 0.0009 0.0002
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0007 0.0714
Echinococcus granulosus orexin receptor type 2 0.0019 0.0009 0.0002
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0159 0.0211 0.0211
Trypanosoma brucei unspecified product 0.0021 0.0011 0.0011
Trypanosoma cruzi C-14 sterol reductase, putative 0.0092 0.0113 0.0125
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0011 0.0073
Plasmodium vivax amine transporter, putative 0.0027 0.002 0.2976
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0019 0.0009 0.0002
Mycobacterium tuberculosis Probable oxidoreductase 0.0135 0.0176 1
Echinococcus multilocularis dna polymerase eta 0.0021 0.0011 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0009 0.0002
Echinococcus granulosus dna polymerase kappa 0.0021 0.0011 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0011 0.0011
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0009 0.0002
Echinococcus granulosus fucosidase alpha L 1 tissue 0.0415 0.0583 0.0576
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0011 0.8127
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.002 0.0012
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0009 0.0002
Schistosoma mansoni neuropeptide receptor 0.0019 0.0009 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0009 0.0002
Leishmania major sterol C-24 reductase, putative 0.0048 0.005 0.005
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0009 0.0002
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0007 0.0714
Brugia malayi Alpha-L-fucosidase family protein 0.0251 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0159 0.0211 0.0204
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0009 0.0001
Echinococcus multilocularis serotonin receptor 0.0019 0.0009 0.0002
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0027 0.002 0.0012
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0011 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0236 0.6359
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0029 0.0022
Schistosoma mansoni Lamin B receptor (ERG24) 0.0092 0.0113 0.0106
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0009 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0349 0.9528
Schistosoma mansoni hypothetical protein 0.0019 0.0009 0.0002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0009 0.0002
Echinococcus granulosus somatostatin receptor 0.0019 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0001
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0011 0.13
Echinococcus multilocularis survival motor neuron protein 1 0.0261 0.0359 0.0352
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.6906 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0009 0.0002
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.002 0.0012
Echinococcus multilocularis somatostatin receptor 0.0019 0.0009 0.0002
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0011 0.0011

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 10 uM In vitro inhibitory activity against superoxide production from human neutrophils stimulated with f-MLP ChEMBL. 7830278

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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