Detailed information for compound 23085

Basic information

Technical information
  • TDR Targets ID: 23085
  • Name: N-(2-bromo-6-chlorophenyl)-N-(cyclopropylmeth yl)-4,5-dihydro-1H-imidazol-2-amine
  • MW: 328.635 | Formula: C13H15BrClN3
  • H donors: 1 H acceptors: 0 LogP: 2.86 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1N(C1=NCCN1)CC1CC1)Br
  • InChi: 1S/C13H15BrClN3/c14-10-2-1-3-11(15)12(10)18(8-9-4-5-9)13-16-6-7-17-13/h1-3,9H,4-8H2,(H,16,17)
  • InChiKey: AEVDCVQMCTUJJP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-bromo-6-chloro-phenyl)-N-(cyclopropylmethyl)-4,5-dihydro-1H-imidazol-2-amine
  • (2-bromo-6-chloro-phenyl)-(cyclopropylmethyl)-(2-imidazolin-2-yl)amine
  • (2-bromo-6-chloro-phenyl)-(cyclopropylmethyl)-(4,5-dihydro-1H-imidazol-2-yl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.037 0.492 0.8456
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0212 0.0516
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0071 0.0803 0.2159
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0055 0.0091
Onchocerca volvulus 0.0435 0.5818 1
Echinococcus granulosus glutamate synthase 0.0019 0.0086 0.014
Brugia malayi hypothetical protein 0.0017 0.0055 0.0082
Schistosoma mansoni apoferritin-2 0.0026 0.0192 0.0329
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.0934 0.1383
Plasmodium vivax hypothetical protein, conserved 0.0116 0.1419 0.5255
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0922 0.1506
Onchocerca volvulus 0.0019 0.0086 0.0148
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0454 0.0742
Schistosoma mansoni hypothetical protein 0.008 0.0934 0.1605
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0218 0.0532
Brugia malayi beta-lactamase family protein 0.0116 0.1419 0.2102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.018 0.0437
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0019 0.0086 0.0152
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.3181 0.4713
Schistosoma mansoni peroxidasin 0.0435 0.5818 1
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0019 0.0086 0.014
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0922 0.1506
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0086 0.0206
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0019 0.0086 0.0073
Loa Loa (eye worm) RNA binding protein 0.0064 0.0712 0.1055
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0071 0.0803 0.2265
Echinococcus granulosus prolyl endopeptidase 0.0267 0.3497 0.571
Loa Loa (eye worm) hypothetical protein 0.0435 0.5818 0.8619
Loa Loa (eye worm) hypothetical protein 0.0116 0.1419 0.2102
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0019 0.0086 0.0127
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0086 0.0206
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0204 0.0463
Plasmodium vivax thioredoxin reductase, putative 0.0205 0.2643 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0712 0.1224
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0028 0.0212 0.0364
Loa Loa (eye worm) hypothetical protein 0.0028 0.0212 0.0314
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.4056 0.8559
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0019 0.0086 0.014
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0046 0.0076
Schistosoma mansoni hypothetical protein 0.0109 0.1325 0.2278
Loa Loa (eye worm) hypothetical protein 0.0435 0.5818 0.8619
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0135 0.0191
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.4056 1
Schistosoma mansoni thyroid hormone receptor 0.0162 0.206 0.3541
Brugia malayi Blistered cuticle protein 3 0.0435 0.5818 0.8619
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0712 0.1224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0314 0.0768
Brugia malayi prolyl oligopeptidase family protein 0.0028 0.0212 0.0314
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0046 0.008
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0019 0.0086 0.0206
Echinococcus granulosus ferritin 0.0026 0.0192 0.0313
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0545 0.089
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.1419 0.3495
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0922 0.4628
Echinococcus multilocularis neuropeptide receptor A26 0.0458 0.6124 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0177 0.0431
Schistosoma mansoni sulfide quinone reductase 0.0019 0.0086 0.0148
Echinococcus granulosus smad 0.0017 0.0055 0.0091
Echinococcus granulosus neuropeptide s receptor 0.0458 0.6124 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.018 0.0369
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.018 0.0451
Loa Loa (eye worm) hypothetical protein 0.0435 0.5818 0.8619
Leishmania major NADH dehydrogenase, putative 0.0019 0.0086 0.0206
Echinococcus granulosus expressed protein 0.0026 0.0192 0.0313
Echinococcus granulosus protein cereblon 0.0357 0.4737 0.7734
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0482 0.1182
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.1893 0.1823
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0028 0.0212 0.0364
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0177 0.0263
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0086 0.0206
Entamoeba histolytica hypothetical protein 0.0109 0.1325 0.2777
Echinococcus multilocularis smad 0.0017 0.0055 0.0091
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.4056 0.8559
Mycobacterium ulcerans lipase LipD 0.0116 0.1419 0.7378
Echinococcus multilocularis protein cereblon 0.0357 0.4737 0.7734
Mycobacterium leprae Probable lipase LipE 0.0116 0.1419 0.7378
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0048 0.0482 0.099
Trichomonas vaginalis glutamate synthase, putative 0.0019 0.0086 0.0206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0214 0.0522
Mycobacterium ulcerans bacterioferritin BfrB 0.0026 0.0192 0.0585
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0019 0.0086 0.0206
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0028 0.0212 0.0346
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0091 0.0134
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.1325 0.2164
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0079 0.0911 0.1349
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0028 0.0212 0.0364
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0028 0.0212 0.0516
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0046 0.0069
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.018 0.0369
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0267 0.3497 1
Schistosoma mansoni ferritin 0.0026 0.0192 0.0329
Echinococcus multilocularis neuropeptide s receptor 0.0458 0.6124 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0071 0.0803 0.8572
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0019 0.0086 0.014
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0086 0.0206
Trichomonas vaginalis glutamate synthase, putative 0.0019 0.0086 0.0206
Entamoeba histolytica thioredoxin reductase, putative 0.0019 0.0086 0.0152
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0086 0.0206
Trichomonas vaginalis penicillin-binding protein, putative 0.0116 0.1419 0.3495
Brugia malayi hypothetical protein 0.0435 0.5818 0.8619
Schistosoma mansoni hypothetical protein 0.0019 0.0086 0.0148
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0106 0.1286 0.3653
Loa Loa (eye worm) hypothetical protein 0.0116 0.1419 0.2102
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0646 0.3098
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0106 0.1286 0.1211
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0079 0.0911 0.1349
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0079 0.0911 0.1487
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0019 0.0086 0.0152
Giardia lamblia GTOR 0.0048 0.0482 0.0996
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.1893 1
Mycobacterium tuberculosis Conserved protein 0.0116 0.1419 0.1345
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0545 0.089
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.1325 0.2278
Loa Loa (eye worm) hypothetical protein 0.0267 0.3497 0.518
Schistosoma mansoni hypothetical protein 0.0174 0.2218 0.3812
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0046 0.0076
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0803 0.2265
Onchocerca volvulus Chorion peroxidase homolog 0.0435 0.5818 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0314 0.0768
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0071 0.0803 0.2265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0252 0.0615
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0267 0.3497 0.601
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0267 0.3497 0.601
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0646 0.111
Loa Loa (eye worm) hypothetical protein 0.0254 0.3325 0.4925
Loa Loa (eye worm) hypothetical protein 0.0435 0.5818 0.8619
Loa Loa (eye worm) hypothetical protein 0.0435 0.5818 0.8619
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0254 0.3325 0.4925
Trypanosoma brucei hypothetical protein, conserved 0.0116 0.1419 0.4034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0218 0.0532
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1106 0.1901
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0048 0.0482 0.099
Onchocerca volvulus 0.0116 0.1419 0.2439
Giardia lamblia NADH oxidase lateral transfer candidate 0.0071 0.0803 0.1806
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0646 0.1054
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0254 0.3325 0.4925
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0116 0.1419 0.2102
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.1325 0.2164
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0192 0.0266
Loa Loa (eye worm) thioredoxin reductase 0.0205 0.2643 0.3915
Echinococcus multilocularis peroxidasin 0.0435 0.5818 0.95
Onchocerca volvulus Dual oxidase homolog 0.0435 0.5818 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.3181 0.4713
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0099 0.0243
Entamoeba histolytica hypothetical protein 0.0109 0.1325 0.2777
Echinococcus multilocularis prolyl endopeptidase 0.0267 0.3497 0.571
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0046 0.0069
Echinococcus granulosus GPCR family 2 0.008 0.0934 0.1525
Echinococcus granulosus peroxidasin 0.0435 0.5818 0.95
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0712 0.1163
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0079 0.0911 0.2575
Brugia malayi RNA binding protein 0.0064 0.0712 0.1055
Mycobacterium tuberculosis Probable peptidase 0.0106 0.1286 0.1211
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0019 0.0086 0.014
Loa Loa (eye worm) beta-lactamase 0.0116 0.1419 0.2102
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0055 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0348 0.0851
Loa Loa (eye worm) hypothetical protein 0.0174 0.2218 0.3286
Loa Loa (eye worm) hypothetical protein 0.0435 0.5818 0.8619
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0116 0.1419 0.1345
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0028 0.0212 0.0419
Brugia malayi prolyl oligopeptidase family protein 0.0028 0.0212 0.0314
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0091 0.0104
Mycobacterium ulcerans hypothetical protein 0.0116 0.1419 0.7378
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0071 0.0803 0.0723
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.015 0.1894 0.3093
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0106 0.1286 0.6644
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0019 0.0086 0.0206
Trypanosoma cruzi prolyl endopeptidase 0.0267 0.3497 1
Brugia malayi Peroxidasin 0.0435 0.5818 0.8619
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.4056 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0071 0.0803 0.3967
Echinococcus multilocularis GPCR, family 2 0.008 0.0934 0.1525
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0545 0.0463
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.1419 0.4034
Brugia malayi MH2 domain containing protein 0.0017 0.0055 0.0082
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0922 1
Leishmania major hypothetical protein, conserved 0.0019 0.0086 0.0206
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.1419 0.3495
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0019 0.0086 0.014
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1106 0.1806
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0071 0.0803 0.2803
Treponema pallidum NADH oxidase 0.0071 0.0803 0.1806
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0071 0.0803 0.2265
Loa Loa (eye worm) programmed cell death 8 0.0019 0.0086 0.0127
Brugia malayi Animal haem peroxidase family protein 0.0435 0.5818 0.8619
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0922 0.2507
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0086 0.0206
Loa Loa (eye worm) hypothetical protein 0.0435 0.5818 0.8619
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.0482 0.1342
Schistosoma mansoni ap endonuclease 0.0019 0.0091 0.0156
Toxoplasma gondii prolyl endopeptidase 0.0267 0.3497 1
Leishmania major oligopeptidase b 0.0106 0.1286 0.3653
Brugia malayi hypothetical protein 0.0026 0.018 0.0267
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0028 0.0212 0.0439
Schistosoma mansoni smad1 5 8 and 0.0017 0.0055 0.0095
Brugia malayi follicle stimulating hormone receptor 0.0503 0.6751 1
Entamoeba histolytica disulphide oxidoreductase, putative 0.0019 0.0086 0.0152
Echinococcus multilocularis acylamino acid releasing enzyme 0.0028 0.0212 0.0346
Loa Loa (eye worm) hypothetical protein 0.0378 0.5036 0.7461
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0046 0.0108
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0091 0.0005
Loa Loa (eye worm) hypothetical protein 0.0435 0.5818 0.8619
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0071 0.0803 0.2865
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.1893 1
Plasmodium falciparum glutathione reductase 0.0071 0.0803 0.2803
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0048 0.0482 0.0828
Giardia lamblia Alanyl dipeptidyl peptidase 0.0028 0.0212 0.0317
Mycobacterium ulcerans esterase/lipase LipP 0.0116 0.1419 0.7378
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0028 0.0212 0.0568
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0079 0.0911 0.2575
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0239 0.3112 0.3052
Plasmodium falciparum glutathione reductase 0.0205 0.2643 1
Schistosoma mansoni hypothetical protein 0.015 0.1894 0.3256
Mycobacterium tuberculosis Probable hydrolase 0.0116 0.1419 0.1345
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0922 0.4628
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0091 0.0018
Schistosoma mansoni glutamate synthase 0.0019 0.0086 0.0148
Onchocerca volvulus Peroxidase homolog 0.0435 0.5818 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.018 0.0477
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0048 0.0482 0.1342
Schistosoma mansoni smad1 5 8 and 0.0017 0.0055 0.0095
Loa Loa (eye worm) hypothetical protein 0.0435 0.5818 0.8619
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0028 0.0212 0.0419
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0028 0.0212 0.0346
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0086 0.0206
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.4056 1
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0212 0.0568
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0086 0.0206
Brugia malayi MH1 domain containing protein 0.0017 0.0055 0.0082
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0091 0.0134
Trypanosoma cruzi NADH dehydrogenase, putative 0.0019 0.0086 0.0206
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0019 0.0086 0.0152
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0922 0.1585
Leishmania major phosphatidylinositol 3-kinase, putative 0.0016 0.0046 0.0093
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0922 0.2106
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0019 0.0086 0.0127
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0086 0.0206
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0712 0.1224
Giardia lamblia Alanyl dipeptidyl peptidase 0.0028 0.0212 0.0317
Schistosoma mansoni smad1 5 8 and 0.0017 0.0055 0.0095
Entamoeba histolytica prolyl oligopeptidase family protein 0.0028 0.0212 0.0419
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0028 0.0212 0.0568
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0348 0.0959
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0803 0.2265
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0071 0.0803 0.2265
Entamoeba histolytica prolyl oligopeptidase family protein 0.0028 0.0212 0.0419
Echinococcus multilocularis thyroid hormone receptor alpha 0.0162 0.206 0.3364
Brugia malayi Animal haem peroxidase family protein 0.0435 0.5818 0.8619
Trypanosoma cruzi trypanothione reductase, putative 0.0071 0.0803 0.2265
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0019 0.0086 0.0206
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0091 0.0219
Loa Loa (eye worm) hypothetical protein 0.0435 0.5818 0.8619
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0104 0.0178
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0071 0.0803 0.2265
Onchocerca volvulus 0.0435 0.5818 1
Mycobacterium tuberculosis Probable esterase LipL 0.0116 0.1419 0.1345
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0055 0.0082
Trypanosoma cruzi trypanothione reductase, putative 0.0205 0.2643 0.7548
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0048 0.0482 0.1342
Brugia malayi TAR-binding protein 0.0064 0.0712 0.1055
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0314 0.0736
Echinococcus granulosus Dipeptidyl peptidase 9 0.0028 0.0212 0.0346
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0071 0.0803 0.2803
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0071 0.0803 0.2265
Onchocerca volvulus Prolyl endopeptidase homolog 0.0267 0.3497 0.601
Echinococcus multilocularis ferritin 0.0026 0.0192 0.0313
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0019 0.0086 0.0206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0214 0.0522
Echinococcus multilocularis geminin 0.037 0.492 0.8033
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0503 0.6751 1
Echinococcus multilocularis expressed protein 0.0026 0.0192 0.0313
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.018 0.0477
Trichomonas vaginalis apoptosis inducing factor, putative 0.0019 0.0086 0.0206
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0646 0.3098
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0922 1
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0106 0.1286 0.3653
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0028 0.0212 0.0364
Brugia malayi Animal haem peroxidase family protein 0.0435 0.5818 0.8619
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0079 0.0911 0.2575
Loa Loa (eye worm) hypothetical protein 0.0116 0.1419 0.2102
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0803 0.2265
Brugia malayi hypothetical protein 0.0357 0.4737 0.7017
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0091 0.0025
Loa Loa (eye worm) blistered cuticle protein 3 0.0435 0.5818 0.8619
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0482 0.0713
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0019 0.0086 0.0073
Echinococcus multilocularis beta LACTamase domain containing family member 0.0116 0.1419 0.2317
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0019 0.0086 0.014
Toxoplasma gondii hypothetical protein 0.0028 0.0212 0.0439
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0803 0.2265
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.0934 0.1383
Loa Loa (eye worm) hypothetical protein 0.0028 0.0212 0.0314
Giardia lamblia Fructose-bisphosphate aldolase 0.0307 0.4056 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0071 0.0803 0.2265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.018 0.0437
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0016 0.0046 0.0093
Toxoplasma gondii ABC1 family protein 0.0116 0.1419 0.3953
Brugia malayi prolyl oligopeptidase family protein 0.0267 0.3497 0.518
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0116 0.1419 0.7378
Echinococcus multilocularis glutamate synthase 0.0019 0.0086 0.014
Plasmodium falciparum thioredoxin reductase 0.0071 0.0803 0.2803
Onchocerca volvulus 0.0435 0.5818 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0071 0.0803 0.0723
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0071 0.0803 0.1189
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0116 0.1419 0.2439
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0177 0.0431
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0055 0.0091
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0137 0.0351
Treponema pallidum fructose-bisphosphate aldolase 0.0307 0.4056 1
Loa Loa (eye worm) animal heme peroxidase 0.0435 0.5818 0.8619
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0046 0.0108
Trichomonas vaginalis glutathione reductase, putative 0.0071 0.0803 0.1974
Toxoplasma gondii exonuclease III APE 0.0019 0.0091 0.0086
Schistosoma mansoni hypothetical protein 0.008 0.0934 0.1605
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0116 0.1419 0.1345
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0019 0.0086 0.0127
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0055 0.0091
Schistosoma mansoni thyroid hormone receptor 0.0162 0.206 0.3541
Schistosoma mansoni hypothetical protein 0.008 0.0934 0.1605
Loa Loa (eye worm) prolyl oligopeptidase 0.0028 0.0212 0.0314
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0545 0.254
Loa Loa (eye worm) hypothetical protein 0.0116 0.1419 0.2102
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0106 0.1286 0.3653
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0071 0.0803 0.8572
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0314 0.0768
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0052 0.0544 0.0806
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0086 0.0206
Onchocerca volvulus Peroxidase homolog 0.0435 0.5818 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0314 0.0768
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.018 0.0439
Loa Loa (eye worm) hypothetical protein 0.0435 0.5818 0.8619
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0348 0.0851
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0266 0.065
Mycobacterium tuberculosis Probable lipase LipE 0.0116 0.1419 0.1345
Loa Loa (eye worm) hypothetical protein 0.0026 0.018 0.0267
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0019 0.0086 0.0206
Brugia malayi glutamate synthase 0.0019 0.0086 0.0127
Schistosoma mansoni ferritin light chain 0.0026 0.0192 0.0329
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0055 0.0082
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0646 0.0957
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0212 0.0568
Plasmodium falciparum peptidase, putative 0.0028 0.0212 0.0492
Brugia malayi Probable ClpP-like protease 0.008 0.0922 0.1366
Schistosoma mansoni Smad4 0.0017 0.0055 0.0095
Loa Loa (eye worm) hypothetical protein 0.0116 0.1419 0.2102
Mycobacterium tuberculosis Probable oxidoreductase 0.0071 0.0803 0.0723
Loa Loa (eye worm) hypothetical protein 0.002 0.0106 0.0158
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0028 0.0212 0.0516
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0048 0.0482 0.1342
Entamoeba histolytica prolyl oligopeptidase family protein 0.0028 0.0212 0.0419
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0212 0.0574
Loa Loa (eye worm) prolyl oligopeptidase 0.0028 0.0212 0.0314
Brugia malayi glutathione reductase 0.0205 0.2643 0.3915
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.018 0.0439
Mycobacterium tuberculosis Conserved protein 0.0116 0.1419 0.1345
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.018 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0348 0.0851
Schistosoma mansoni ferritin 0.0026 0.0192 0.0329
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1106 0.1806
Echinococcus granulosus thioredoxin glutathione reductase 0.0205 0.2643 0.4316
Loa Loa (eye worm) animal heme peroxidase 0.0435 0.5818 0.8619
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0019 0.0086 0.0073
Schistosoma mansoni ferritin light chain 0.0026 0.0192 0.0329
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0712 0.1055
Loa Loa (eye worm) hypothetical protein 0.0116 0.1419 0.2102
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0016 0.0046 0.0093
Entamoeba histolytica hypothetical protein 0.0109 0.1325 0.2777
Leishmania major hypothetical protein, conserved 0.0019 0.0086 0.0206
Brugia malayi beta-lactamase 0.0116 0.1419 0.2102
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0116 0.1419 0.2439
Loa Loa (eye worm) animal heme peroxidase 0.0435 0.5818 0.8619
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0026 0.0192 0.1263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0348 0.0851
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0046 0.0108
Echinococcus granulosus Smad4 0.0017 0.0055 0.0091
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0071 0.0803 0.2265
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0204 0.0545
Mycobacterium tuberculosis Probable lipase LipD 0.0116 0.1419 0.1345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0348 0.0851
Trypanosoma brucei oligopeptidase b 0.0106 0.1286 0.3653
Schistosoma mansoni smad 0.0017 0.0055 0.0095
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1106 0.1901
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0071 0.0803 0.3967
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0048 0.0482 0.0786
Mycobacterium ulcerans bacterioferritin BfrA 0.0026 0.0192 0.0585
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.0934 0.1525
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0052 0.0544 0.0806
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0046 0.0093
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0091 0.0217
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0646 0.1814
Brugia malayi prolyl oligopeptidase family protein 0.0028 0.0212 0.0314
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0055 0.0091
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0803 0.2265
Leishmania major hypothetical protein, conserved 0.0026 0.018 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0314 0.0768
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0071 0.0803 0.8572
Loa Loa (eye worm) RecQ helicase 0.0025 0.0177 0.0263
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0026 0.0192 0.0585
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0046 0.0093
Schistosoma mansoni ap endonuclease 0.0019 0.0091 0.0156
Toxoplasma gondii hypothetical protein 0.0027 0.0204 0.0417
Schistosoma mansoni ferritin 0.0026 0.0192 0.0329
Trichomonas vaginalis mercuric reductase, putative 0.0071 0.0803 0.1974
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0482 0.0713
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0922 0.4628
Echinococcus granulosus beta LACTamase domain containing family member 0.0116 0.1419 0.2317
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1106 0.1806
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0019 0.0086 0.014
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0019 0.0086 0.014
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0071 0.0803 0.2265
Onchocerca volvulus Protein cereblon homolog 0.0357 0.4737 0.8141
Onchocerca volvulus Peroxidasin homolog 0.0435 0.5818 1
Brugia malayi beta-lactamase family protein 0.0116 0.1419 0.2102
Entamoeba histolytica hypothetical protein, conserved 0.0028 0.0212 0.0419
Trypanosoma brucei prolyl endopeptidase 0.0267 0.3497 1
Loa Loa (eye worm) Smad1 0.0017 0.0055 0.0082
Loa Loa (eye worm) hypothetical protein 0.0435 0.5818 0.8619
Plasmodium vivax glutathione reductase, putative 0.0205 0.2643 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0922 1
Brugia malayi hypothetical protein 0.0145 0.1826 0.2705
Trichomonas vaginalis esterase, putative 0.0116 0.1419 0.3495
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0646 0.1054
Brugia malayi Calcitonin receptor-like protein seb-1 0.0254 0.3325 0.4925
Schistosoma mansoni disulfide oxidoreductase 0.0019 0.0086 0.0148
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0079 0.0911 0.1566
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0712 0.1055
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0712 0.1055
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0204 0.0655
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0028 0.0212 0.0568
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0091 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0482 0.1182
Schistosoma mansoni hypothetical protein 0.0357 0.4737 0.8141
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0071 0.0803 0.3967
Brugia malayi MH1 domain containing protein 0.0017 0.0055 0.0082
Trypanosoma brucei NADH dehydrogenase 0.0019 0.0086 0.0206
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.0934 0.1525
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0177 0.029
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0106 0.1286 0.3653
Trypanosoma brucei trypanothione reductase 0.0205 0.2643 0.7548
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0019 0.0086 0.0152
Echinococcus granulosus acylamino acid releasing enzyme 0.0028 0.0212 0.0346
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0028 0.0212 0.0568
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0046 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0482 0.1182
Trypanosoma brucei prolyl oligopeptidase, putative 0.0106 0.1286 0.3653
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0106 0.1286 0.6644
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0192 0.0107
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0019 0.0086 0.014
Schistosoma mansoni peroxidasin 0.0435 0.5818 1
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0019 0.0086 0.0152
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0028 0.0212 0.0568
Brugia malayi prolyl oligopeptidase family protein 0.0028 0.0212 0.0314
Loa Loa (eye worm) hypothetical protein 0.0019 0.0086 0.0127
Trypanosoma cruzi oligopeptidase b 0.0106 0.1286 0.3653
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0019 0.0086 0.0127
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0014 0.0028
Schistosoma mansoni ferritin 0.0026 0.0192 0.0329
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0079 0.0911 0.1899
Schistosoma mansoni glutamate synthase 0.0019 0.0086 0.0148
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0091 0.0148
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0019 0.0086 0.0206
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0071 0.0803 0.1311
Plasmodium vivax ferrodoxin reductase, putative 0.0019 0.0086 0.0086
Mycobacterium tuberculosis Conserved protein 0.0116 0.1419 0.1345
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.4056 1
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0028 0.0212 0.0364
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0019 0.0086 0.0086
Loa Loa (eye worm) animal heme peroxidase 0.0435 0.5818 0.8619
Entamoeba histolytica hypothetical protein 0.0109 0.1325 0.2777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.018 0.0439
Trypanosoma cruzi oligopeptidase b 0.0106 0.1286 0.3653
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0348 0.0959
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0071 0.0803 0.3967
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0079 0.0911 0.2575
Brugia malayi Latrophilin receptor protein 2 0.008 0.0934 0.1383
Brugia malayi Thioredoxin reductase 0.0205 0.2643 0.3915
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0086 0.0206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0314 0.0768
Toxoplasma gondii selenide, water dikinase 0.0019 0.0086 0.0073
Brugia malayi latrophilin 2 splice variant baaae 0.0174 0.2218 0.3286
Echinococcus granulosus tar DNA binding protein 0.0064 0.0712 0.1163
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1106 0.1901
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0048 0.0482 0.1342
Echinococcus granulosus bloom syndrome protein 0.0025 0.0177 0.029
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0071 0.0803 0.0723
Loa Loa (eye worm) hypothetical protein 0.0435 0.5818 0.8619
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0348 0.0959
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0019 0.0086 0.0206
Brugia malayi MH2 domain containing protein 0.0244 0.3181 0.4713
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0019 0.0086 0.014
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0646 0.0565
Trichomonas vaginalis penicillin-binding protein, putative 0.0116 0.1419 0.3495
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0028 0.0212 0.0346
Mycobacterium leprae conserved hypothetical protein 0.0116 0.1419 0.7378
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1106 0.1806
Onchocerca volvulus 0.0116 0.1419 0.2439
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0019 0.0086 0.0073
Schistosoma mansoni hypothetical protein 0.037 0.492 0.8456
Leishmania major hypothetical protein, conserved 0.0116 0.1419 0.4034
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0922 0.2507
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0046 0.0108
Loa Loa (eye worm) hypothetical protein 0.008 0.0922 0.1366
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0016 0.0046 0.0093
Brugia malayi MH2 domain containing protein 0.0017 0.0055 0.0082
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0204 0.0298
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0205 0.2643 0.2579
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0091 0.0055
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0803 0.2265
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0116 0.1419 0.2102
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.0934 0.1525
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0071 0.0803 0.1311
Schistosoma mansoni sulfide quinone reductase 0.0019 0.0086 0.0148
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0116 0.1419 0.1345
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0071 0.0803 0.138
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.1419 0.4034
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0019 0.0086 0.0206
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0091 0.0217
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.4056 1
Brugia malayi Animal haem peroxidase family protein 0.0435 0.5818 0.8619
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0454 0.0742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.018 0.0439
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0091 0.0219
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0028 0.0212 0.0439
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0922 0.327
Echinococcus multilocularis thioredoxin glutathione reductase 0.0205 0.2643 0.4316
Leishmania major hypothetical protein, conserved 0.0019 0.0086 0.0206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0386 0.0945
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0019 0.0086 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.018 0.0437
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0091 0.0162
Leishmania major trypanothione reductase 0.0205 0.2643 0.7548
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.018 0.0347
Trypanosoma cruzi NADH dehydrogenase, putative 0.0019 0.0086 0.0206
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0019 0.0086 0.0206
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0086 0.0206
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0019 0.0086 0.0086
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0019 0.0086 0.014
Brugia malayi Smad1 0.0017 0.0055 0.0082
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0028 0.0212 0.0568
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0922 0.3328
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0048 0.0482 0.1342
Trichomonas vaginalis ferritin, putative 0.0026 0.0192 0.0466
Loa Loa (eye worm) glutathione reductase 0.0205 0.2643 0.3915
Toxoplasma gondii NADPH-glutathione reductase 0.0071 0.0803 0.2159
Echinococcus granulosus geminin 0.037 0.492 0.8033
Loa Loa (eye worm) hypothetical protein 0.0435 0.5818 0.8619
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0071 0.0803 0.2265
Loa Loa (eye worm) hypothetical protein 0.008 0.0934 0.1383
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0591 0.0875
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0071 0.0803 0.2865
Onchocerca volvulus Peroxidasin homolog 0.0435 0.5818 1
Echinococcus granulosus neuropeptide receptor A26 0.0458 0.6124 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.0934 0.1525
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.4056 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.015 0.1894 0.3093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0218 0.0532
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.1106 0.1638
Loa Loa (eye worm) hypothetical protein 0.0357 0.4737 0.7017
Entamoeba histolytica hypothetical protein, conserved 0.0357 0.4737 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0091 0.0219
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0545 0.0463
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.1419 0.3495
Toxoplasma gondii thioredoxin reductase 0.0205 0.2643 0.7515
Onchocerca volvulus 0.0116 0.1419 0.2439
Schistosoma mansoni apoferritin-2 0.0026 0.0192 0.0329
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0019 0.0086 0.0206
Mycobacterium ulcerans beta-lactamase 0.0116 0.1419 0.7378
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.4056 1
Schistosoma mansoni glutamate synthase 0.0019 0.0086 0.0148
Echinococcus multilocularis Smad4 0.0017 0.0055 0.0091
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0712 0.1224
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0091 0.0148
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.4056 1
Schistosoma mansoni hypothetical protein 0.008 0.0934 0.1605
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.1106 0.1638
Brugia malayi Animal haem peroxidase family protein 0.0435 0.5818 0.8619
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0314 0.0768
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0019 0.0086 0.0073
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0048 0.0482 0.0786
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0086 0.0206
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0091 0.0219
Plasmodium falciparum thioredoxin reductase 0.0205 0.2643 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0079 0.0911 0.1487
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0192 0.0107
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0091 0.0012
Brugia malayi hypothetical protein 0.0109 0.1325 0.1963
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0712 0.1224

Activities

Activity type Activity value Assay description Source Reference
D150 (functional) = 0.42 mg kg-1 Dose required to decrease heart rate after iv injection to spinal rats ChEMBL. 7452671
logD (ADMET) = -0.79 Partition coefficient (logD7.4) ChEMBL. 7452671
pKa = 10.8 Dissociation constant (pKa) ChEMBL. 7452671
Relative activity (functional) = 1.48 Evaluated for decreased heart rate in spinal rats, relative activity was determined ChEMBL. 7452671

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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