Detailed information for compound 232769

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 288.371 | Formula: C13H16N6S
  • H donors: 3 H acceptors: 1 LogP: 1.19 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCNc1cnc(c2c1cccc2)/C=N\N=C(/S)\N
  • InChi: 1S/C13H16N6S/c14-5-6-16-11-7-17-12(8-18-19-13(15)20)10-4-2-1-3-9(10)11/h1-4,7-8,16H,5-6,14H2,(H3,15,19,20)/b18-8-
  • InChiKey: CHSNFKGUPHWKFL-LSCVHKIXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni chromobox protein 0.0013 0.0004 0.0004
Brugia malayi PXA domain containing protein 0.0022 0.0045 0.0139
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0045 0.0139
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0057 0.0469
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0043 0.0094
Leishmania major hypothetical protein, conserved 0.0018 0.0027 0.0171
Trichomonas vaginalis dullard protein, putative 0.0014 0.0009 0.0013
Schistosoma mansoni DNA helicase recq5 0.0019 0.0031 0.0031
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0181 0.0779 0.7514
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0046 0.036
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0046 0.0101
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0125 0.0519 0.2454
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0069 0.0156
Echinococcus multilocularis dnaJ subfamily B 0.0475 0.213 0.2127
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0085 0.0742
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0104 0.0423 0.042
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0169 0.0722 0.2414
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0046 0.0078
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0452 0.2023 1
Leishmania major basic transcription factor 3a, putative 0.0075 0.0288 0.2726
Trichomonas vaginalis helicase, putative 0.0014 0.0008 0.001
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0019 0.003 0.0027
Echinococcus granulosus dna polymerase kappa 0.0022 0.0046 0.0042
Trichomonas vaginalis glutaminase, putative 0.0317 0.1405 0.3337
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0045 0.0042
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0046 0.036
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0102 0.0413 0.394
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0049 0.0388
Trichomonas vaginalis phosphofructokinase, putative 0.0237 0.1033 0.2453
Entamoeba histolytica hypothetical protein 0.0013 0.0004 0.000000000086808
Schistosoma mansoni chromobox protein 0.0013 0.0004 0.0004
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0043 0.0039
Echinococcus multilocularis mitogen activated protein kinase 0.0102 0.0413 0.0409
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0924 0.4202 1
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0014 0.0009 0.0005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.009
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0046 0.036
Loa Loa (eye worm) hypothetical protein 0.0058 0.0209 0.0691
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0924 0.4202 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0048 0.0044
Trichomonas vaginalis phosphofructokinase, putative 0.0064 0.0237 0.0557
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.003 0.0208
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.0000000001224
Onchocerca volvulus 0.0082 0.032 0.0931
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0209 0.0691
Schistosoma mansoni aldehyde dehydrogenase 0.0132 0.0552 0.0552
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0046 0.036
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0043 0.004
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0296 0.2798
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0046 0.036
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0064 0.0237 0.0545
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0014 0.0009 0.0009
Mycobacterium ulcerans glutaminase 0.0317 0.1405 0.6895
Brugia malayi Bloom's syndrome protein homolog 0.0046 0.0157 0.0514
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0046 0.0142
Trichomonas vaginalis phosphofructokinase, putative 0.0237 0.1033 0.2453
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0046 0.0042
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0014 0.0009 0.0013
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.003 0.0936
Echinococcus granulosus expressed protein 0.0433 0.1939 0.1936
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0168 0.0718 0.0714
Leishmania major cytochrome p450-like protein 0.0031 0.0085 0.0742
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0086 0.1497
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0004 0.000000027145
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0046 0.036
Echinococcus granulosus mixed lineage leukemia protein mll 0.0019 0.003 0.0027
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0018 0.0027 0.0417
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.032 0.1062
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0004 0.000000000086808
Brugia malayi jmjC domain containing protein 0.0018 0.0027 0.0077
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0031 0.0092
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0064 0.0237 0.8212
Plasmodium falciparum glutathione reductase 0.0019 0.003 0.0936
Onchocerca volvulus 0.075 0.34 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0057 0.1403
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0102 0.0413 0.394
Echinococcus granulosus mitogen activated protein kinase 3 0.0102 0.0413 0.0409
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0049 0.0154
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.0027 0.0804
Echinococcus granulosus bloom syndrome protein 0.0046 0.0157 0.0153
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0013 0.0004 0.000000000036461
Loa Loa (eye worm) hypothetical protein 0.0118 0.0484 0.1614
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.0009 0.0013
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0139 0.0584 0.2777
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0288 0.0678
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0274 0.0274
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0069 0.0156
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0296 0.2798
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0027 0.0077
Echinococcus granulosus lysine specific demethylase 5A 0.0072 0.0274 0.027
Onchocerca volvulus 0.0058 0.0209 0.0605
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0209 0.0691
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0049 0.1186
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0064 0.0237 0.8212
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0045 0.0139
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0413 0.0974
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0237 0.1033 0.2404
Schistosoma mansoni aldehyde dehydrogenase 0.0132 0.0552 0.0552
Echinococcus multilocularis transcription factor btf3 0.0075 0.0288 0.0285
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0046 0.036
Mycobacterium ulcerans aldehyde dehydrogenase 0.0132 0.0552 0.2617
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.032 0.0316
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0057 0.0469
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0171 0.0167
Echinococcus granulosus mitogen activated protein kinase 0.0102 0.0413 0.0409
Schistosoma mansoni hypothetical protein 0.0167 0.0712 0.0712
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0043 0.0094
Loa Loa (eye worm) hypothetical protein 0.0037 0.0113 0.0369
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0045 0.0139
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0924 0.4202 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0452 0.2023 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0136 0.057 0.057
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0057 0.0468
Echinococcus granulosus geminin 0.0167 0.0712 0.0708
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.003 0.003
Leishmania major hypothetical protein, conserved 0.0025 0.0057 0.0468
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0296 0.2798
Trypanosoma brucei transcription factor BTF3, putative 0.0075 0.0288 0.2726
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0045 0.0139
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.003 0.0027
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0027 0.0023
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0022 0.0045 0.0139
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0014 0.0009 0.0009
Toxoplasma gondii NAC domain-containing protein 0.0075 0.0288 0.519
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0027 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0046 0.036
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0091 0.0362 0.0358
Trichomonas vaginalis phosphofructokinase, putative 0.0237 0.1033 0.2453
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0181 0.0779 0.3755
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0027 0.0027
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.0027 0.0171
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0924 0.4202 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0096 0.0384 0.038
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.003 0.0027
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0046 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0008 0.001
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0043 0.0133
Echinococcus multilocularis lamin 0.0058 0.0209 0.0206
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0045 0.0042
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.003 0.0051
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.003 0.0027
Trichomonas vaginalis DNA helicase recq1, putative 0.0046 0.0157 0.0365
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0924 0.4202 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0139 0.0584 0.2777
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0046 0.0042
Brugia malayi intermediate filament protein 0.0058 0.0209 0.0691
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0924 0.4202 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0077
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0152 0.0352
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0057 0.0973
Loa Loa (eye worm) hypothetical protein 0.0368 0.1639 0.5492
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0031 0.05
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0102 0.0413 0.394
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0045 0.0045
Schistosoma mansoni cpg binding protein 0.0063 0.0231 0.0231
Trypanosoma brucei unspecified product 0.0015 0.0014 0.0047
Plasmodium falciparum glutathione reductase 0.0055 0.0196 0.6743
Loa Loa (eye worm) CYP4Cod1 0.0031 0.0085 0.0273
Schistosoma mansoni cpg binding protein 0.0066 0.0247 0.0247
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.003 0.0027
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0171 0.3045
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0085 0.0275
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0104 0.0423 0.0423
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0452 0.2023 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.003 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0008 0.001
Schistosoma mansoni lamin 0.0058 0.0209 0.0209
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0046 0.036
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.032 0.0316
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0046 0.0101
Brugia malayi hypothetical protein 0.0025 0.0057 0.0179
Echinococcus multilocularis microtubule associated protein 2 0.2183 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0014 0.0047
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0045 0.0042
Schistosoma mansoni DNA polymerase eta 0.0022 0.0046 0.0046
Schistosoma mansoni jumonji domain containing protein 0.0068 0.0257 0.0257
Echinococcus granulosus histone acetyltransferase KAT2B 0.0164 0.0696 0.0693
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.003 0.0208
Brugia malayi phosphofructokinase 0.0237 0.1033 0.3458
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0045 0.0139
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0004 0.0004
Brugia malayi SET domain containing protein 0.0018 0.0026 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0014 0.0047
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0413 0.0974
Brugia malayi jmjC domain containing protein 0.0072 0.0274 0.0907
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.003 0.0208
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0071 0.0068
Loa Loa (eye worm) hypothetical protein 0.0027 0.0066 0.0211
Loa Loa (eye worm) 6-phosphofructokinase 0.0237 0.1033 0.3458
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0064 0.0237 0.0557
Trypanosoma brucei trypanothione reductase 0.0055 0.0196 0.1821
Loa Loa (eye worm) hypothetical protein 0.0022 0.0045 0.0139
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0384 0.0384
Entamoeba histolytica phosphofructokinase, putative 0.0237 0.1033 0.2453
Onchocerca volvulus 0.0109 0.0445 0.1299
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0049 0.0154
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0046 0.0101
Mycobacterium ulcerans aldehyde dehydrogenase 0.0132 0.0552 0.2617
Trichomonas vaginalis set domain proteins, putative 0.075 0.34 0.809
Treponema pallidum fructose-bisphosphate aldolase 0.0924 0.4202 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0126 0.0524 0.9483
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0008 0.001
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0139 0.0584 0.271
Plasmodium vivax basic transcription factor 3b, putative 0.0075 0.0288 0.7484
Loa Loa (eye worm) phosphofructokinase 0.0237 0.1033 0.3458
Schistosoma mansoni hypothetical protein 0.0167 0.0712 0.0712
Loa Loa (eye worm) POT family protein 0.008 0.0313 0.1039
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0057 0.0127
Plasmodium vivax 6-phosphofructokinase, putative 0.0064 0.0237 0.6146
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0196 0.0192
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0181 0.0779 0.3755
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0196 0.0192
Brugia malayi beta-NAC-like protein 0.0075 0.0288 0.0956
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0045 0.0042
Trypanosoma brucei unspecified product 0.0022 0.0046 0.036
Trypanosoma cruzi transcription factor btf3, putative 0.0075 0.0288 0.2726
Brugia malayi jmjC domain containing protein 0.0018 0.0027 0.0077
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0413 0.0974
Onchocerca volvulus 0.0118 0.0484 0.1415
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.002 0.0016
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0413 0.0974
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0043 0.702
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0049 0.0049
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0004 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0069 0.0156
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0049 0.0049
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.003 0.0208
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0152 0.034
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.066 0.2982 1
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0104 0.0423 0.042
Mycobacterium ulcerans 6-phosphofructokinase 0.0237 0.1033 0.5033
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0171 0.0398
Echinococcus multilocularis dna polymerase eta 0.0022 0.0046 0.0042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0924 0.4202 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0031 0.0092
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0045 0.0042
Schistosoma mansoni intermediate filament proteins 0.0058 0.0209 0.0209
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0924 0.4202 1
Echinococcus granulosus lamin 0.0058 0.0209 0.0206
Plasmodium falciparum basic transcription factor 3b, putative 0.0075 0.0288 1
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0045 0.0139
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0027 0.0066 0.0211
Schistosoma mansoni ap endonuclease 0.0022 0.0043 0.0043
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0031 0.0085 0.0275
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0171 0.3045
Schistosoma mansoni microtubule-associated protein tau 0.2183 1 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0045 0.0139
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0237 0.1033 0.5033
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.003 0.0208
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0043 0.1391
Schistosoma mansoni chromobox protein 0.0013 0.0004 0.0004
Echinococcus multilocularis geminin 0.0167 0.0712 0.0708
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0045 0.0139
Schistosoma mansoni chromobox protein 0.0013 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0045 0.0099
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0046 0.036
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0181 0.0779 0.2603
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0031 0.0053
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0014 0.0009 0.0098
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0015
Brugia malayi MAP kinase sur-1 0.0102 0.0413 0.1373
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0132 0.0552 0.0549
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0104 0.0423 0.0423
Mycobacterium ulcerans aldehyde dehydrogenase 0.0132 0.0552 0.2617
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0017 0.002 0.002
Schistosoma mansoni 6-phosphofructokinase 0.0237 0.1033 0.1033
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0049 0.0822
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0045 0.0045
Brugia malayi glutaminase DH11.1 0.0317 0.1405 0.4704
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0031 0.0027
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.003 0.0208
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0004 0.000000000086808
Brugia malayi CXXC zinc finger family protein 0.0063 0.0231 0.0763
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0046 0.0142
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0022 0.0046 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0045 0.0099
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0085 0.0273
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0085 0.0742
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0049 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0045 0.0099
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0027 0.0171
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0027 0.0023
Brugia malayi jmjC domain containing protein 0.0018 0.0027 0.0077
Loa Loa (eye worm) CHromoDomain protein family member 0.0017 0.002 0.0055
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.003 0.0486
Trypanosoma brucei cytochrome P450, putative 0.0031 0.0085 0.0742
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0027 0.0027
Schistosoma mansoni DNA helicase recq1 0.0019 0.0031 0.0031
Echinococcus granulosus intermediate filament protein 0.0058 0.0209 0.0206
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0018
Trichomonas vaginalis phosphofructokinase, putative 0.0064 0.0237 0.0557
Leishmania major DNA polymerase kappa, putative 0.0022 0.0046 0.036
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0171 0.439
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.0274 0.0907
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0077 0.0296 0.0981
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0057 0.1875
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0045 0.0099
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0237 0.1033 0.4986
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0043 0.0334
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0027 0.0171
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0057 0.0469
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0004 0.000000000086808
Leishmania major trypanothione reductase 0.0055 0.0196 0.1821
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0007 0.0011
Brugia malayi Pre-SET motif family protein 0.066 0.2982 1
Schistosoma mansoni hypothetical protein 0.0013 0.0004 0.0004
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0064 0.0237 0.4262
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0109 0.0445 0.0445
Trichomonas vaginalis dullard protein, putative 0.0014 0.0009 0.0013
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.003 0.0063
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0013 0.0004 0.0000000012807
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0096 0.0384 0.6935
Toxoplasma gondii 6-phosphofructokinase 0.0064 0.0237 0.4262
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0046 0.0078
Brugia malayi hypothetical protein 0.0016 0.0016 0.0043
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0043 0.0082
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0085 0.0275
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0077 0.0296 0.0296
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0045 0.0045
Plasmodium vivax JmjC domain containing protein 0.0018 0.0027 0.0602
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0384 0.0384
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0049 0.0388
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0043 0.0133
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0924 0.4202 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0008 0.001
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0045 0.0042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0069 0.0156
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0043 0.0065
Schistosoma mansoni lamin 0.0058 0.0209 0.0209
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0046 0.036
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0014 0.0009 0.0141
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.003 0.0701
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0046 0.0046
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0041 0.0131 0.4468
Brugia malayi PXA domain containing protein 0.0022 0.0045 0.0139
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0168 0.0718 0.0718
Onchocerca volvulus 0.0063 0.0231 0.0669
Loa Loa (eye worm) RecQ helicase 0.0046 0.0157 0.0514
Echinococcus multilocularis 0.0014 0.0009 0.0005
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.032 0.032
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0045 0.0042
Echinococcus granulosus histone lysine methyltransferase setb 0.0096 0.0384 0.038
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0027 0.0023
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0045 0.0042
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0057 0.1875
Leishmania major ATP-dependent phosphofructokinase 0.0237 0.1033 1
Brugia malayi 6-phosphofructokinase 0.0237 0.1033 0.3458
Brugia malayi POT family protein 0.008 0.0313 0.1039
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0147 0.0143
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0045 0.0045
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0046 0.036
Brugia malayi Cytochrome P450 family protein 0.0034 0.0099 0.0321
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0196 0.0644
Echinococcus multilocularis expressed protein 0.0433 0.1939 0.1936
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0181 0.0779 0.0775
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0046 0.036
Echinococcus granulosus CTD small phosphatase protein like 0.0014 0.0009 0.0005
Entamoeba histolytica hypothetical protein 0.0022 0.0045 0.0099
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0384 0.0384
Mycobacterium tuberculosis Probable oxidoreductase 0.0139 0.0584 0.2777
Loa Loa (eye worm) glutathione reductase 0.0055 0.0196 0.0644
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0077 0.0296 0.0696
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0031 0.0092
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0046 0.0078
Echinococcus multilocularis bloom syndrome protein 0.0046 0.0157 0.0153
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0043 0.0031
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0068 0.0257 0.0254
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0077 0.0296 0.0292
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0043 0.0065
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0064 0.0237 0.0557
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0049 0.0046
Toxoplasma gondii thioredoxin reductase 0.0055 0.0196 0.3499
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.003 0.0936
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0043 0.0334
Echinococcus granulosus dna polymerase eta 0.0022 0.0046 0.0042
Trichomonas vaginalis dullard protein, putative 0.0014 0.0009 0.0013
Brugia malayi Thioredoxin reductase 0.0055 0.0196 0.0644
Toxoplasma gondii exonuclease III APE 0.0022 0.0043 0.0722
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0046 0.036
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.003 0.0089
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0014 0.0009 0.0189
Loa Loa (eye worm) hypothetical protein 0.0022 0.0045 0.0139
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0069 0.0156
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0045 0.0042
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0043 0.0094
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0069 0.0156
Loa Loa (eye worm) hypothetical protein 0.0057 0.0204 0.0674
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0069 0.0156
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.003 0.0208
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0057 0.0468
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0132 0.0552 0.2617
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0014 0.0047
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0196 0.1821
Echinococcus granulosus 6 phosphofructokinase 0.0237 0.1033 0.103
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0048 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0046 0.036
Brugia malayi hypothetical protein 0.0141 0.0594 0.1981
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0046 0.036
Giardia lamblia Kinase, CMGC MAPK 0.0102 0.0413 0.0963
Schistosoma mansoni 6-phosphofructokinase 0.0237 0.1033 0.1033
Entamoeba histolytica phosphofructokinase, putative 0.0237 0.1033 0.2453
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0099 0.0321
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.003 0.0208
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0102 0.0413 0.394
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0102 0.0413 0.394
Echinococcus multilocularis lamin dm0 0.0058 0.0209 0.0206
Brugia malayi hypothetical protein 0.0118 0.0484 0.1614
Echinococcus multilocularis 6 phosphofructokinase 0.0237 0.1033 0.103
Schistosoma mansoni hypothetical protein 0.0014 0.0008 0.0008
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0125 0.0519 0.2454
Plasmodium vivax 6-phosphofructokinase, putative 0.0064 0.0237 0.6146
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0045 0.0045
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0049 0.0046
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0045 0.0042
Echinococcus multilocularis mitogen activated protein kinase 3 0.0102 0.0413 0.0409
Trypanosoma cruzi transcription factor btf3, putative 0.0075 0.0288 0.2726
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.0009 0.0013
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0027 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0046 0.036
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0077 0.0296 0.0292
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0071 0.0068
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0004 0.000000000086808
Loa Loa (eye worm) glutaminase 2 0.0317 0.1405 0.4704
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0046 0.0142
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0043 0.0334
Brugia malayi hypothetical protein 0.0022 0.0045 0.0139
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0049 0.0049
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0043 0.0334
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0004 0.000000000086808
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0045 0.0042
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0125 0.0519 0.2454
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0064 0.0237 1
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0045 0.0045
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0049 0.0891
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0196 0.5046
Loa Loa (eye worm) hypothetical protein 0.0025 0.0057 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0008 0.001
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0045 0.0045
Schistosoma mansoni glutaminase 0.0317 0.1405 0.1405
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0077 0.0296 0.2798
Entamoeba histolytica transcription factor BTF3, putative 0.0075 0.0288 0.0678
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.003 0.0208
Echinococcus granulosus cpg binding protein 0.0066 0.0247 0.0244
Schistosoma mansoni transcription factor btf3 0.0075 0.0288 0.0288
Trypanosoma brucei unspecified product 0.0015 0.0014 0.0047
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0049 0.0822
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0413 0.0413
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0046 0.036
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0152 0.5199
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0008 0.001
Entamoeba histolytica hypothetical protein 0.0023 0.0049 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0008 0.001
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0027 0.0027
Toxoplasma gondii aldehyde dehydrogenase 0.0132 0.0552 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0049 0.0154
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0237 0.1033 1
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0147 0.0143
Entamoeba histolytica hypothetical protein 0.0022 0.0045 0.0099
Brugia malayi Pre-SET motif family protein 0.0096 0.0384 0.1277
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0069 0.0156
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.003 0.0701
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0031 0.0027
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0007 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0045 0.0099
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.003 0.0208
Loa Loa (eye worm) histone methyltransferase 0.0023 0.0048 0.0148
Trichomonas vaginalis phosphofructokinase, putative 0.0064 0.0237 0.0557
Onchocerca volvulus 0.0118 0.0484 0.1415
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0031 0.0087 0.2204
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0102 0.0413 0.1373
Trichomonas vaginalis DNA helicase recq, putative 0.0046 0.0157 0.0365
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0031 0.05
Loa Loa (eye worm) hypothetical protein 0.0118 0.0484 0.1614
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0171 0.0398
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0031 0.0027
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0096 0.0384 0.038
Plasmodium falciparum thioredoxin reductase 0.0055 0.0196 0.6743
Trichomonas vaginalis phosphofructokinase, putative 0.0064 0.0237 0.0557
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0014 0.0009 0.0141
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.0009 0.0013
Schistosoma mansoni hypothetical protein 0.006 0.0219 0.0219
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0077 0.0296 0.0981
Trichomonas vaginalis phosphofructokinase, putative 0.0237 0.1033 0.2453
Trypanosoma brucei protein kinase, putative 0.0102 0.0413 0.394
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0077
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0043 0.004
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0102 0.0413 0.394
Schistosoma mansoni cpg binding protein 0.0066 0.0247 0.0247
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0046 0.036
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0004 0.0000000001224
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.002 0.0016
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0014 0.0009 0.0018
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0231 0.0763
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0068 0.0257 0.0254
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0274 0.0274
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0049 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0008 0.001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0045 0.0139
Brugia malayi hypothetical protein 0.0022 0.0045 0.0139
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0045 0.0042
Schistosoma mansoni hypothetical protein 0.0475 0.213 0.213
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.003 0.0208
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0043 0.0039
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0027 0.0023
Loa Loa (eye worm) ICD-1 protein 0.0075 0.0288 0.0956
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0125 0.0519 0.2454
Giardia lamblia DINP protein human, muc B family 0.0022 0.0046 0.0088
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0064 0.0237 1
Plasmodium falciparum thioredoxin reductase 0.0019 0.003 0.0936
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0022 0.0045 0.0099
Entamoeba histolytica hypothetical protein 0.0022 0.0045 0.0099
Loa Loa (eye worm) hypothetical protein 0.0096 0.0384 0.1277
Brugia malayi acetyltransferase, GNAT family protein 0.0168 0.0718 0.2398
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0034 0.0072
Plasmodium vivax glutathione reductase, putative 0.0055 0.0196 0.5046
Mycobacterium tuberculosis Probable reductase 0.0125 0.0519 0.2454
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0049 0.0044
Toxoplasma gondii phosphofructokinase PFKII 0.0064 0.0237 0.4262
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0196 0.0829
Brugia malayi glutathione reductase 0.0055 0.0196 0.0644
Echinococcus granulosus Chromo domain 0.0013 0.0004 0.000000000036461
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0045 0.0042
Echinococcus multilocularis lysine specific demethylase 5A 0.0068 0.0257 0.0254
Loa Loa (eye worm) hypothetical protein 0.0022 0.0045 0.0139
Echinococcus granulosus transcription factor btf3 0.0075 0.0288 0.0285
Echinococcus granulosus dnaJ subfamily B 0.0475 0.213 0.2127
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.003 0.0208
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.003 0.0486
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0288 0.0678
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0039 0.0083
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0209 0.0691
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0031 0.0963
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.003 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0008 0.001
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0045 0.0042
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0027 0.0027
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0045 0.0045
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0102 0.0413 0.7459
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.003 0.0208
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0014 0.0009 0.0005
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0181 0.0779 0.0779
Entamoeba histolytica hypothetical protein 0.0075 0.0288 0.0678
Loa Loa (eye worm) 6-phosphofructokinase 0.0237 0.1033 0.3458
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0237 0.1033 1
Echinococcus multilocularis cpg binding protein 0.0066 0.0247 0.0244
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0045 0.0139
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0004 0.000000000086808
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0102 0.0413 0.394
Brugia malayi M-phase phosphoprotein, mpp8 0.0118 0.0484 0.1614
Plasmodium vivax SET domain protein, putative 0.0096 0.0384 1
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0013 0.0004 0.00000000066469
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0057 0.0468
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.003 0.0208
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0045 0.0045
Brugia malayi jmjC domain containing protein 0.0018 0.0027 0.0077
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0132 0.0552 0.0549
Echinococcus multilocularis musashi 0.0058 0.0209 0.0206
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0027 0.0077
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0049 0.1584
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0027 0.0023
Giardia lamblia Fructose-bisphosphate aldolase 0.0924 0.4202 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0046 0.036
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0004 0.00000000095844
Echinococcus multilocularis Chromo domain 0.0013 0.0004 0.000000000036461
Brugia malayi Cytochrome P450 family protein 0.0031 0.0085 0.0273
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0288 0.0678
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0018 0.0027 0.0417
Loa Loa (eye worm) acetyltransferase 0.0168 0.0718 0.2398
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0071 0.0227
Echinococcus granulosus Chromobox protein 3 0.0013 0.0004 0.000000027145
Brugia malayi jmjC domain containing protein 0.0068 0.0257 0.0851
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0064 0.0237 0.0496
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0125 0.0519 0.2384
Trichomonas vaginalis phosphofructokinase, putative 0.0064 0.0237 0.0557
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0045 0.0099
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0039 0.0083
Schistosoma mansoni ap endonuclease 0.0022 0.0043 0.0043
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0045 0.0042
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0046 0.0046
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0049 0.0093
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0045 0.0045
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.003 0.0063
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0013 0.0004 0.0000000001224
Loa Loa (eye worm) hypothetical protein 0.0082 0.032 0.1062
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0092
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0046 0.0078
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0049 0.0093
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0924 0.4202 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0181 0.0779 0.0775
Entamoeba histolytica recQ family helicase, putative 0.0025 0.0057 0.0127
Onchocerca volvulus 0.0058 0.0209 0.0605
Brugia malayi Cytochrome P450 family protein 0.0031 0.0085 0.0273
Entamoeba histolytica phosphofructokinase, putative 0.0237 0.1033 0.2453
Brugia malayi 6-phosphofructokinase 0.0237 0.1033 0.3458
Schistosoma mansoni blooms syndrome DNA helicase 0.0037 0.0112 0.0112
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0181 0.0779 0.3755
Trichomonas vaginalis phosphofructokinase, putative 0.0064 0.0237 0.0557
Echinococcus granulosus Solute carrier family 22 5 0.102 0.4641 0.4639
Loa Loa (eye worm) glutaminase 0.0317 0.1405 0.4704
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0013 0.0004 0.000000000036461
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0085 0.0273
Brugia malayi CHD4 protein 0.0017 0.002 0.0055
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.003 0.0208
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0031 0.0027
Leishmania major DNA polymerase eta, putative 0.0022 0.0046 0.036
Echinococcus granulosus phd:f box containing protein 0.0018 0.0027 0.0023
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0027 0.0023
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0045 0.0042
Mycobacterium tuberculosis Probable dehydrogenase 0.0125 0.0519 0.2454
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0132 0.0552 0.53
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0004 0.0004
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0045 0.0045
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0047 0.0145
Echinococcus granulosus lamin dm0 0.0058 0.0209 0.0206
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0043 0.1041

Activities

Activity type Activity value Assay description Source Reference
Average weight (functional) = -5 % antineoplastic activity on the survival time of mice bearing L1210 leukemia. Average weight change of mice from onset to termination of drug treatment. ChEMBL. 7473550
Average weight (functional) = -5 % antineoplastic activity on the survival time of mice bearing L1210 leukemia. Average weight change of mice from onset to termination of drug treatment. ChEMBL. 7473550
Average weight (functional) = -4.6 % antineoplastic activity on the survival time of mice bearing L1210 leukemia. Average weight change of mice from onset to termination of drug treatment. ChEMBL. 7473550
Average weight (functional) = -4.6 % antineoplastic activity on the survival time of mice bearing L1210 leukemia. Average weight change of mice from onset to termination of drug treatment. ChEMBL. 7473550
Dose (functional) = 20 mg kg-1 antineoplastic activity on the survival time of mice bearing L1210 leukemia. Daily dosage of the compound. ChEMBL. 7473550
Dose (functional) = 20 mg kg-1 antineoplastic activity on the survival time of mice bearing L1210 leukemia. Daily dosage of the compound. ChEMBL. 7473550
Dose (functional) = 40 mg kg-1 antineoplastic activity on the survival time of mice bearing L1210 leukemia. Daily dosage of the compound. ChEMBL. 7473550
Dose (functional) = 40 mg kg-1 antineoplastic activity on the survival time of mice bearing L1210 leukemia. Daily dosage of the compound. ChEMBL. 7473550
Dose (functional) = 60 mg kg-1 antineoplastic activity on the survival time of mice bearing L1210 leukemia. Daily dosage of the compound. ChEMBL. 7473550
Dose (functional) = 60 mg kg-1 antineoplastic activity on the survival time of mice bearing L1210 leukemia. Daily dosage of the compound. ChEMBL. 7473550
T/C (functional) = 116 % antineoplastic activity on the survival time of mice bearing L1210 leukemia.% T/C represents the ratio of the survival time of treated to control mice * 100. ChEMBL. 7473550
T/C (functional) = 116 % antineoplastic activity on the survival time of mice bearing L1210 leukemia.% T/C represents the ratio of the survival time of treated to control mice * 100. ChEMBL. 7473550
T/C (functional) = 120 % antineoplastic activity on the survival time of mice bearing L1210 leukemia.% T/C represents the ratio of the survival time of treated to control mice * 100. ChEMBL. 7473550
T/C (functional) = 120 % antineoplastic activity on the survival time of mice bearing L1210 leukemia.% T/C represents the ratio of the survival time of treated to control mice * 100. ChEMBL. 7473550
T/C (functional) = 145 % antineoplastic activity on the survival time of mice bearing L1210 leukemia.% T/C represents the ratio of the survival time of treated to control mice * 100. ChEMBL. 7473550
T/C (functional) = 145 % antineoplastic activity on the survival time of mice bearing L1210 leukemia.% T/C represents the ratio of the survival time of treated to control mice * 100. ChEMBL. 7473550

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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