Detailed information for compound 255114

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 896.206 | Formula: C40H65N5O12SSi2
  • H donors: 2 H acceptors: 7 LogP: 3.81 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: OCC1C=CC(O1)n1cc(C)c(=O)n(c1=O)CCCCCCn1c(=O)c(C)cn(c1=O)C1OC(C2(C1O[Si](C(C)(C)C)(C)C)OS(=O)(=O)C=C2N)CO[Si](C(C)(C)C)(C)C
  • InChi: 1S/C40H65N5O12SSi2/c1-26-21-44(31-18-17-28(23-46)54-31)36(49)42(33(26)47)19-15-13-14-16-20-43-34(48)27(2)22-45(37(43)50)35-32(56-60(11,12)39(6,7)8)40(29(41)25-58(51,52)57-40)30(55-35)24-53-59(9,10)38(3,4)5/h17-18,21-22,25,28,30-32,35,46H,13-16,19-20,23-24,41H2,1-12H3
  • InChiKey: RXRUPEKXJDCHTK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0053 0.0282
Loa Loa (eye worm) hypothetical protein 0.0173 0.0435 0.2771
Schistosoma mansoni coup transcription factor 0.0043 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0051
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1032
Echinococcus multilocularis transcription factor btf3 0.0073 0.0161 0.0152
Loa Loa (eye worm) hypothetical protein 0.0043 0.0079 0.0457
Schistosoma mansoni hypothetical protein 0.0033 0.0053 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0043 0.0079 0.0457
Trypanosoma brucei chrX additional, unordered contigs 0.0025 0.0031 0.0552
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.002 0.0157
Brugia malayi hypothetical protein 0.002 0.0017 0.0051
Schistosoma mansoni terminal deoxycytidyl transferase 0.0082 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0056 0.0116 0.0692
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0022 0.0277
Loa Loa (eye worm) hypothetical protein 0.0056 0.0116 0.0692
Entamoeba histolytica deoxycytidyl transferase, putative 0.0082 0.0185 1
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0049 0.0094 0.0171
Schistosoma mansoni hypothetical protein 0.0309 0.0809 0.0809
Schistosoma mansoni smad1 5 8 and 0.0018 0.0009 0.0009
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0022 0.0019
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0075 0.0168 0.0629
Loa Loa (eye worm) hypothetical protein 0.0043 0.0079 0.0457
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0017 0.0051
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0017 0.0051
Echinococcus multilocularis GPCR, family 2 0.0033 0.0053 0.0043
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0107 0.0197
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0041 0.0864
Brugia malayi steroid hormone receptor 0.0043 0.0079 0.0457
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0022 0.0515
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.002 0.001
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0017 0.0017
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0026 0.0017
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0022 0.0277
Loa Loa (eye worm) glutaminase 2 0.0578 0.1546 1
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0053 0.0282
Trypanosoma cruzi DNA polymerase kappa, putative 0.0082 0.0185 0.538
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0051 0.0051
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0168 0.1032
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0022 0.0277
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0056 0.0116 0.0215
Echinococcus granulosus GPCR family 2 0.0033 0.0053 0.0043
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0328 0.0328
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0043 0.0079 0.0457
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0043 0.0079 0.007
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0022 0.0019
Plasmodium falciparum DNA repair protein REV1, putative 0.0025 0.0031 0.1191
Echinococcus granulosus L aminoadipate semialdehyde 0.0173 0.0435 0.0426
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0022 0.0082
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0043 0.0079 0.007
Schistosoma mansoni nuclear receptor 0.002 0.0017 0.0017
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0079 0.0178 0.3903
Loa Loa (eye worm) hypothetical protein 0.0043 0.0079 0.0457
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0075 0.0168 0.0324
Trypanosoma cruzi DNA polymerase eta, putative 0.0135 0.0333 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0022 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0328 0.0328
Echinococcus granulosus dna polymerase kappa 0.0082 0.0185 0.0176
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0022 0.0019
Brugia malayi nuclear receptor NHR-67 0.002 0.0017 0.0051
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0079 0.007
Leishmania major phosphopantetheinyl transferase-like protein 0.0049 0.0094 0.2549
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.0643 0.0635
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0049 0.0094 0.0171
Onchocerca volvulus 0.0075 0.0168 0.2429
Trichomonas vaginalis ran, putative 0.0021 0.002 0.0043
Echinococcus multilocularis lamin dm0 0.0114 0.0275 0.0266
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0152 0.4334
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0022 0.0082
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0097 0.0088
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0168 0.4844
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0071 0.0062
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0159 0.0973
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0022 0.0019
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0022 0.0019
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0049 0.0094 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0053 0.0043
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0022 0.0019
Schistosoma mansoni smad 0.0018 0.0009 0.0009
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0031 0.0552
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0022 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0079 0.007
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0024 0.0024
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0041 0.0031
Loa Loa (eye worm) DR-78 0.002 0.0017 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0043 0.0079 0.0457
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0018 0.003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0097 0.0088
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0017 0.0008
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0022 0.0058
Loa Loa (eye worm) hypothetical protein 0.0043 0.0079 0.0457
Echinococcus granulosus muscleblind protein 0.016 0.0401 0.0392
Echinococcus granulosus mixed lineage leukemia protein mll 0.0024 0.0026 0.0017
Leishmania major DNA polymerase kappa, putative 0.0025 0.0031 0.0552
Onchocerca volvulus 0.0114 0.0275 0.4149
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0022 0.0277
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0043 0.0079 0.0457
Onchocerca volvulus Bile acid receptor homolog 0.0043 0.0079 0.1007
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0097 0.0569
Echinococcus multilocularis ecdysone induced protein 78C 0.0043 0.0079 0.007
Trypanosoma brucei unspecified product 0.0082 0.0185 0.538
Echinococcus multilocularis geminin 0.018 0.0456 0.0447
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0051
Brugia malayi CXXC zinc finger family protein 0.0091 0.021 0.131
Loa Loa (eye worm) hypothetical protein 0.0053 0.0107 0.0635
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0185 0.538
Echinococcus multilocularis lamin 0.0114 0.0275 0.0266
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0043 0.0079 0.0457
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0022 0.0019
Schistosoma mansoni hypothetical protein 0.018 0.0456 0.0456
Echinococcus multilocularis muscleblind protein 0.016 0.0401 0.0392
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0031 0.0552
Mycobacterium tuberculosis Conserved hypothetical protein 0.0082 0.0185 0.036
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0022 0.0209
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0075 0.0168 0.0324
Schistosoma mansoni zinc finger protein 0.002 0.0017 0.0017
Brugia malayi photoreceptor-specific nuclear receptor 0.0043 0.0079 0.0457
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1032
Loa Loa (eye worm) hypothetical protein 0.0249 0.0643 0.4124
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0152 0.0152
Echinococcus granulosus cpg binding protein 0.0096 0.0225 0.0216
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0082 0.0185 0.1122
Brugia malayi hypothetical protein 0.0023 0.0024 0.0094
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0067 0.0058
Entamoeba histolytica hypothetical protein 0.0023 0.0026 0.0733
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0094
Schistosoma mansoni cpg binding protein 0.0096 0.0225 0.0225
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0031 0.0552
Leishmania major DNA damage repair protein, putative 0.0025 0.0031 0.0552
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0031 0.0552
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0043 0.0079 0.0457
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0053 0.0282
Schistosoma mansoni ap endonuclease 0.0019 0.0013 0.0013
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0079 0.0079
Entamoeba histolytica hypothetical protein 0.0039 0.0067 0.3147
Loa Loa (eye worm) hypothetical protein 0.0056 0.0116 0.0692
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0026 0.0082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0097 0.0097
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0152 0.0926
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0013 0.0004
Entamoeba histolytica hypothetical protein 0.0039 0.0067 0.3147
Brugia malayi hypothetical protein 0.002 0.0017 0.0051
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0026 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0043 0.0079 0.0457
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0185 0.538
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0161 0.0966
Schistosoma mansoni hypothetical protein 0.0033 0.0053 0.0053
Brugia malayi conserved hypotetical protein 0.002 0.0017 0.0051
Onchocerca volvulus 0.0247 0.0638 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0026 0.0082
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0022 0.0019
Entamoeba histolytica acyl-CoA synthetase, putative 0.0075 0.0168 0.9005
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0075 0.0168 0.0324
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0079 0.0457
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0082 0.0185 0.1143
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0018 0.003
Onchocerca volvulus 0.0173 0.0435 0.6731
Loa Loa (eye worm) hypothetical protein 0.0033 0.0051 0.0273
Echinococcus granulosus lamin dm0 0.0114 0.0275 0.0266
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0017 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0022 0.0019
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0043 0.0079 0.007
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0152 0.4334
Schistosoma mansoni retinoic acid receptor RXR 0.0043 0.0079 0.0079
Mycobacterium ulcerans DNA polymerase IV 0.0082 0.0185 0.036
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0043 0.0079 0.1007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0018 0.003
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0022 0.0019
Brugia malayi Pre-SET motif family protein 0.0033 0.0051 0.0273
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0097 0.0088
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0022 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0082 0.0185 0.538
Echinococcus granulosus FTZ F1 alpha 0.0043 0.0079 0.007
Brugia malayi cytoplasmic intermediate filament protein 0.0061 0.0129 0.078
Onchocerca volvulus 0.0091 0.021 0.3115
Schistosoma mansoni ran 0.0021 0.002 0.002
Brugia malayi Steroid receptor seven-up type 2 0.0043 0.0079 0.0457
Trypanosoma cruzi DNA polymerase kappa, putative 0.0082 0.0185 0.538
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0024 0.0026 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0115 0.3207
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0017 0.0051
Loa Loa (eye worm) hypothetical protein 0.0161 0.0402 0.2557
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0055 0.0112 0.0103
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0168 0.1032
Schistosoma mansoni Smad4 0.0018 0.0009 0.0009
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0152 0.0142
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0031 0.0552
Giardia lamblia DINP protein human, muc B family 0.0082 0.0185 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0051
Trypanosoma cruzi DNA polymerase kappa, putative 0.0082 0.0185 0.538
Echinococcus granulosus X box binding protein 1 0.0303 0.0792 0.0784
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.002 0.0208
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0022 0.0019
Schistosoma mansoni importin beta-1 0.0029 0.0041 0.0041
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.004 0.0203
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0094
Trypanosoma brucei transcription factor BTF3, putative 0.0073 0.0161 0.4634
Brugia malayi beta-NAC-like protein 0.0073 0.0161 0.0988
Schistosoma mansoni smad1 5 8 and 0.0018 0.0009 0.0009
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0043 0.0079 0.0079
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0031 0.0552
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0031 0.0552
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0018 0.003
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0152 0.0142
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0022 0.0019
Entamoeba histolytica hypothetical protein 0.0073 0.0161 0.8613
Schistosoma mansoni cpg binding protein 0.0096 0.0225 0.0225
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0017 0.0008
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0097 0.0569
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0049 0.0094 0.1923
Plasmodium falciparum acyl-CoA synthetase 0.0056 0.0116 0.6927
Brugia malayi hypothetical protein 0.0039 0.0067 0.0377
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.025 0.1568
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0022 0.0019
Loa Loa (eye worm) ICD-1 protein 0.0073 0.0161 0.0988
Schistosoma mansoni hypothetical protein 0.0303 0.0792 0.0792
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0051 0.0051
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0022 0.0277
Loa Loa (eye worm) hypothetical protein 0.0072 0.0159 0.0973
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0134 0.0328 0.2077
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0022 0.0013
Trypanosoma cruzi DNA polymerase eta, putative 0.0079 0.0178 0.5172
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0097 0.0097
Brugia malayi hypothetical protein 0.0023 0.0024 0.0094
Mycobacterium leprae conserved hypothetical protein 0.0049 0.0094 0.0313
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0022 0.0082
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0022 0.0598
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0022 0.0209
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.002 0.0387
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0017 0.0017
Schistosoma mansoni transcription factor btf3 0.0073 0.0161 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0018 0.003
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0051
Entamoeba histolytica acyl-coA synthetase, putative 0.0075 0.0168 0.9005
Leishmania major DNA polymerase eta, putative 0.0135 0.0333 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0022 0.0277
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0017 0.0051
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0082 0.0185 0.0176
Loa Loa (eye worm) CXXC zinc finger family protein 0.0091 0.021 0.131
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0082
Schistosoma mansoni steroid hormone receptor ad4bp 0.0043 0.0079 0.0079
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0082 0.0185 0.538
Loa Loa (eye worm) hypothetical protein 0.0029 0.0041 0.0204
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0152 0.0926
Echinococcus granulosus dna polymerase eta 0.0135 0.0333 0.0324
Loa Loa (eye worm) hypothetical protein 0.016 0.0401 0.2549
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0185 0.538
Plasmodium vivax basic transcription factor 3b, putative 0.0073 0.0161 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0079 0.0457
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0017 0.0008
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0051
Onchocerca volvulus 0.0051 0.01 0.134
Loa Loa (eye worm) hypothetical protein 0.0112 0.0269 0.169
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0051
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0024 0.0094
Schistosoma mansoni hypothetical protein 0.0033 0.0053 0.0053
Echinococcus multilocularis dnaJ subfamily B 0.1294 0.3513 0.3507
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0079 0.0457
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0051
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0061 0.0129 0.078
Schistosoma mansoni hypothetical protein 0.0072 0.0159 0.0159
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0328 0.0328
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0018 0.003
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0043 0.0079 0.0457
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0022 0.0019
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0067 0.0067
Onchocerca volvulus 0.0022 0.0022 0.0078
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0022 0.0209
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0026 0.0394
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0056 0.0116 0.0215
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.025 0.1568
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0022 0.0019
Schistosoma mansoni DNA polymerase IV / kappa 0.0025 0.0031 0.0031
Schistosoma mansoni glutaminase 0.0578 0.1546 0.1546
Entamoeba histolytica hypothetical protein 0.0039 0.0067 0.3147
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0026 0.0082
Loa Loa (eye worm) TAR-binding protein 0.0134 0.0328 0.2077
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.002 0.0068
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0018 0.003
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0168 0.0324
Trypanosoma brucei DNA polymerase eta, putative 0.0135 0.0333 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0043 0.0079 0.007
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.0557 0.3562
Mycobacterium ulcerans imidazoleglycerol-phosphate dehydratase 0.1759 0.4788 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0056 0.0116 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.01 0.0592
Brugia malayi ecdysteroid receptor 0.0043 0.0079 0.0457
Echinococcus multilocularis thyroid hormone receptor alpha 0.0043 0.0079 0.007
Echinococcus multilocularis muscleblind protein 1 0.016 0.0401 0.0392
Echinococcus granulosus geminin 0.018 0.0456 0.0447
Schistosoma mansoni RAR-like nuclear receptor 0.0043 0.0079 0.0079
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0023 0.0024 0.0014
Schistosoma mansoni intermediate filament proteins 0.0114 0.0275 0.0275
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0051 0.0042
Loa Loa (eye worm) hypothetical protein 0.0055 0.0112 0.0672
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0043 0.0079 0.0457
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0018 0.003
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0017 0.0008
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0022 0.0019
Loa Loa (eye worm) oxidoreductase 0.0022 0.0022 0.0082
Brugia malayi Nuclear hormone receptor E75 0.002 0.0017 0.0051
Loa Loa (eye worm) hypothetical protein 0.0105 0.025 0.1568
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0051
Leishmania major GTP-binding protein, putative 0.0021 0.002 0.0208
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0022 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0043 0.0079 0.0457
Schistosoma mansoni ap endonuclease 0.0019 0.0013 0.0013
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0051 0.0042
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0053 0.0043
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0022 0.0019
Echinococcus granulosus tar DNA binding protein 0.0134 0.0328 0.032
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0082 0.0185 0.0176
Echinococcus multilocularis X box binding protein 1 0.0303 0.0792 0.0784
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0079 0.0079
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0013 0.0004
Entamoeba histolytica transcription factor BTF3, putative 0.0073 0.0161 0.8613
Loa Loa (eye worm) MH2 domain-containing protein 0.0257 0.0667 0.4277
Giardia lamblia DNA damage repair protein 0.0025 0.0031 0.1026
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0018 0.003
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0053 0.0043
Loa Loa (eye worm) hypothetical protein 0.0135 0.0333 0.2104
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0079 0.0079
Echinococcus multilocularis cpg binding protein 0.0096 0.0225 0.0216
Schistosoma mansoni DNA polymerase eta 0.0135 0.0333 0.0333
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0067 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0185 0.538
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0051 0.0903
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0023 0.0024 0.0094
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0194 0.0493 0.0493
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0022 0.0082
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0018 0.003
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0023 0.0024 0.0014
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0017 0.0051
Echinococcus granulosus dnaJ subfamily B 0.1294 0.3513 0.3507
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0107 0.0197
Mycobacterium tuberculosis Probable imidazole glycerol-phosphate dehydratase HisB 0.1759 0.4788 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0022 0.0019
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0022 0.0022
Brugia malayi ImpB/MucB/SamB family protein 0.0082 0.0185 0.1143
Onchocerca volvulus 0.0022 0.0022 0.0078
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0094
Brugia malayi intermediate filament protein 0.0114 0.0275 0.1727
Trypanosoma brucei unspecified product 0.0056 0.0115 0.3207
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0041 0.0032
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0168 0.4844
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0152 0.4334
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0022 0.0082
Entamoeba histolytica hypothetical protein 0.0039 0.0067 0.3147
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0075 0.0168 0.0324
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0107 0.0197
Onchocerca volvulus 0.0022 0.0022 0.0078
Brugia malayi nuclear receptor NHR-88 0.002 0.0017 0.0051
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0022 0.0277
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0043 0.0079 0.0457
Trichomonas vaginalis set domain proteins, putative 0.0247 0.0638 0.4077
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0051
Loa Loa (eye worm) hypothetical protein 0.016 0.0401 0.2549
Echinococcus granulosus importin subunit beta 1 0.0029 0.0041 0.0031
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0168 0.1032
Brugia malayi Nuclear hormone receptor E75 0.002 0.0017 0.0051
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0026 0.0017
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0018 0.003
Loa Loa (eye worm) RNA binding protein 0.0134 0.0328 0.2077
Brugia malayi hypothetical protein 0.0249 0.0643 0.4124
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0079 0.0079
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0043 0.0079 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0018 0.003
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.002 0.0449
Loa Loa (eye worm) hypothetical protein 0.0056 0.0116 0.0692
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0017 0.0008
Echinococcus granulosus snurportin 1 0.0309 0.0809 0.0801
Schistosoma mansoni smad1 5 8 and 0.0018 0.0009 0.0009
Echinococcus multilocularis dna polymerase kappa 0.0082 0.0185 0.0176
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0043 0.0079 0.007
Loa Loa (eye worm) intermediate filament protein 0.0114 0.0275 0.1727
Leishmania major basic transcription factor 3a, putative 0.0073 0.0161 0.4634
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0185 0.538
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0079 0.0457
Trypanosoma brucei DNA polymerase IV, putative 0.0082 0.0185 0.538
Loa Loa (eye worm) hypothetical protein 0.0043 0.0079 0.0457
Schistosoma mansoni nuclear receptor 0.002 0.0017 0.0017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0097 0.0097
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0049 0.0094 0.1923
Trypanosoma cruzi transcription factor btf3, putative 0.0073 0.0161 0.4634
Schistosoma mansoni nuclear hormone receptor 0.002 0.0017 0.0017
Entamoeba histolytica acyl-CoA synthetase, putative 0.0075 0.0168 0.9005
Onchocerca volvulus Protein ultraspiracle homolog 0.0043 0.0079 0.1007
Toxoplasma gondii NAC domain-containing protein 0.0073 0.0161 0.3496
Echinococcus granulosus lamin 0.0114 0.0275 0.0266
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0075 0.0168 0.0324
Echinococcus granulosus transcription factor btf3 0.0073 0.0161 0.0152
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0022 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0185 0.538
Trypanosoma brucei hypothetical protein, conserved 0.0049 0.0094 0.2549
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0079 0.0457
Trypanosoma brucei DNA polymerase IV, putative 0.0082 0.0185 0.538
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0041 0.0864
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0152 0.8056
Loa Loa (eye worm) hypothetical protein 0.0043 0.0079 0.0457
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0114 0.0275 0.1727
Toxoplasma gondii histone lysine methyltransferase SET1 0.0173 0.0437 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.0275 0.1727
Brugia malayi MH2 domain containing protein 0.0257 0.0667 0.4277
Brugia malayi TAR-binding protein 0.0134 0.0328 0.2077
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0043 0.0079 0.0457
Plasmodium vivax SET domain protein, putative 0.0033 0.0051 0.2583
Brugia malayi RNA recognition motif domain containing protein 0.0134 0.0328 0.2077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0051 0.0051
Brugia malayi glutaminase DH11.1 0.0578 0.1546 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0043 0.0079 0.007
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0017 0.0008
Plasmodium vivax DNA repair protein REV1, putative 0.0025 0.0031 0.1191
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0018 0.003
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0168 0.0324
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0043 0.0033
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0094
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0043 0.0079 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0018 0.003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0075 0.0168 0.0324
Echinococcus multilocularis dna polymerase eta 0.0135 0.0333 0.0324
Leishmania major DNA polymerase eta, putative 0.0079 0.0178 0.5172
Brugia malayi ImpB/MucB/SamB family protein 0.0135 0.0333 0.2104
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0022 0.0019
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0168 0.4844
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0051
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0017 0.0008
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0082 0.0185 0.0185
Trichomonas vaginalis glutaminase, putative 0.0578 0.1546 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0018 0.003
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0017 0.0008
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.002 0.0449
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0022 0.0019
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.002 0.001
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0022 0.0598
Echinococcus multilocularis musashi 0.0114 0.0275 0.0266
Schistosoma mansoni hypothetical protein 0.1294 0.3513 0.3513
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0043 0.0079 0.007
Plasmodium falciparum importin beta, putative 0.0029 0.0041 0.1865
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0009 0.0009
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0022 0.0277
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0031 0.0552
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0049 0.0094 1
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.0643 0.0635
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0043 0.0079 0.007
Schistosoma mansoni ran 0.0021 0.002 0.002
Mycobacterium leprae Probable imidazole glycerol-phosphate dehydratase HisB 0.0868 0.2342 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0055 0.0112 0.0103
Echinococcus multilocularis FTZ F1 alpha 0.0043 0.0079 0.007
Schistosoma mansoni nuclear hormone receptor 0.002 0.0017 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0043 0.0079 0.0457
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0049 0.0094 0.55
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0018 0.003
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0152 0.4334
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0022 0.0082
Trichomonas vaginalis DNA polymerase eta, putative 0.0082 0.0185 0.1122
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0017 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0115 0.3207
Mycobacterium ulcerans hypothetical protein 0.0025 0.0031 0.0037
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0168 0.0324
Brugia malayi Importin beta-1 subunit 0.0029 0.0041 0.0204
Schistosoma mansoni survival motor neuron protein 0.0051 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0043 0.0079 0.0457
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0043 0.0079 0.0457
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0185 0.538
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0049 0.0094 0.0171
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0013 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0082
Loa Loa (eye worm) transcription factor SMAD2 0.0257 0.0667 0.4277
Onchocerca volvulus 0.0033 0.0051 0.0551
Onchocerca volvulus 0.0161 0.0402 0.6203
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0031 0.0552
Brugia malayi nuclear receptor RXR 0.002 0.0017 0.0051
Schistosoma mansoni microtubule-associated protein tau 0.3659 1 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0022 0.0019
Onchocerca volvulus 0.0114 0.0275 0.4149
Trypanosoma cruzi transcription factor btf3, putative 0.0073 0.0161 0.4634
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0024 0.0094
Mycobacterium ulcerans DNA polymerase IV 0.0082 0.0185 0.036
Schistosoma mansoni hypothetical protein 0.018 0.0456 0.0456
Leishmania major DNA polymerase kappa, putative 0.0082 0.0185 0.538
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0025 0.0031 0.0416
Schistosoma mansoni hypothetical protein 0.0039 0.0067 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0185 0.538
Brugia malayi ecdysone receptor 0.002 0.0017 0.0051
Echinococcus multilocularis L aminoadipate semialdehyde 0.0173 0.0435 0.0426
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0097 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0079 0.0457
Loa Loa (eye worm) hypothetical protein 0.0056 0.0116 0.0692
Brugia malayi nuclear hormone receptor 0.0043 0.0079 0.0457
Trichomonas vaginalis helicase, putative 0.0021 0.0018 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0161 0.0966
Brugia malayi Intermediate filament tail domain containing protein 0.0114 0.0275 0.1727
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0013 0.0024
Mycobacterium ulcerans hypothetical protein 0.0075 0.0168 0.0324
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0022 0.0019
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.025 0.1568
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0838 0.226 0.2253
Echinococcus multilocularis snurportin 1 0.0309 0.0809 0.0801
Schistosoma mansoni lamin 0.0114 0.0275 0.0275
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0043 0.0079 0.0079
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0075 0.0168 0.0629
Echinococcus multilocularis tar DNA binding protein 0.0134 0.0328 0.032
Entamoeba histolytica hypothetical protein 0.0049 0.0094 0.4737
Trypanosoma brucei unspecified product 0.0056 0.0115 0.3207
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0173 0.0435 0.0435
Brugia malayi RNA binding protein 0.0134 0.0328 0.2077
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0185 0.538
Entamoeba histolytica Ran family GTPase 0.0021 0.002 0.0387
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0161 0.0966
Loa Loa (eye worm) hypothetical protein 0.0075 0.0168 0.1032
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0049 0.0094 0.55
Loa Loa (eye worm) hypothetical protein 0.0033 0.0053 0.0282
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0022 0.0082
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0051 0.0042
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0041 0.0209
Onchocerca volvulus 0.0043 0.0079 0.1007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0079 0.0457
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0051
Schistosoma mansoni cpg binding protein 0.0091 0.021 0.021
Trypanosoma brucei DNA polymerase IV, putative 0.0082 0.0185 0.538
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0079 0.007
Brugia malayi hypothetical protein 0.0161 0.0402 0.2557
Loa Loa (eye worm) glutaminase 0.0578 0.1546 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0022 0.0019
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.002 0.0208
Loa Loa (eye worm) steroid hormone receptor 0.0043 0.0079 0.0457
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0022 0.0058
Brugia malayi RNA, U transporter 1 0.0082 0.0187 0.1157
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0309 0.0809 0.5206
Schistosoma mansoni hypothetical protein 0.0033 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0053 0.0107 0.0635
Plasmodium falciparum basic transcription factor 3b, putative 0.0073 0.0161 1
Mycobacterium ulcerans glutaminase 0.0578 0.1546 0.3211
Schistosoma mansoni hypothetical protein 0.0051 0.01 0.01
Leishmania major importin beta-1 subunit, putative 0.0023 0.0026 0.0394
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0043 0.0079 0.007
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0017 0.0008
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0023 0.0024 0.0024
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0041 0.0032
Brugia malayi Muscleblind-like protein 0.016 0.0401 0.2549
Echinococcus multilocularis microtubule associated protein 2 0.3659 1 1
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0094
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0022 0.0277
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0043 0.0079 0.0079
Echinococcus granulosus ecdysone induced protein 78C 0.0043 0.0079 0.007
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0328 0.0328
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0031 0.0552
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.002 0.0208
Plasmodium vivax importin-beta 2, putative 0.0029 0.0041 0.1865
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.0139
Brugia malayi Pre-SET motif family protein 0.0217 0.0557 0.3562
Brugia malayi nuclear receptor RXR 0.0023 0.0024 0.0094
Echinococcus granulosus transcription factor Dp 1 0.004 0.0071 0.0062
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0173 0.0435 0.2771
Brugia malayi nuclear hormone receptor 0.002 0.0017 0.0051
Plasmodium vivax acyl-CoA synthetase, putative 0.0056 0.0116 0.6927
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0022 0.0013
Onchocerca volvulus 0.0022 0.0022 0.0078
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0082 0.0185 0.036
Echinococcus granulosus intermediate filament protein 0.0114 0.0275 0.0266
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0185 0.538
Schistosoma mansoni lamin 0.0114 0.0275 0.0275
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0079 0.007
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0079 0.0457
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0025 0.0031 0.0416
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0053 0.0043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0051 0.0051
Brugia malayi tailless protein 0.002 0.0017 0.0051
Brugia malayi polk-prov protein 0.0025 0.0031 0.0139
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0041 0.0652
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.002 0.0068
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0017 0.0051
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0107 0.0197
Brugia malayi nuclear receptor NHR-88 0.0043 0.0079 0.0457
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0115 0.3207
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.0013 0.0001
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0017 0.0008
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0017 0.0051
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0018 0.003
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0051

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) = 116 uM Cytostatic concentration against MT-4 cell ChEMBL. 10602704
CC50 (functional) > 250 uM Cytostatic concentration against CEM cell ChEMBL. 10602704
EC50 (functional) = 0.12 uM Inhibition of HIV-1 induced cytopathicity against CEM cell ChEMBL. 10602704
EC50 (functional) = 0.23 uM Inhibition of HIV-1 induced cytopathicity against MT-4 cell ChEMBL. 10602704
EC50 (functional) > 50 uM Inhibition of HIV-2 induced cytopathicity against CEM cell ChEMBL. 10602704
EC50 (functional) > 250 uM Inhibition of HIV-2 induced cytopathicity against MT-4 cell ChEMBL. 10602704

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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