Detailed information for compound 25823

Basic information

Technical information
  • TDR Targets ID: 25823
  • Name: 2-[bis(2-hydroxyethylamino)methylideneamino]a cetic acid
  • MW: 205.212 | Formula: C7H15N3O4
  • H donors: 5 H acceptors: 4 LogP: -2.12 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCNC(=NCC(=O)O)NCCO
  • InChi: 1S/C7H15N3O4/c11-3-1-8-7(9-2-4-12)10-5-6(13)14/h11-12H,1-5H2,(H,13,14)(H2,8,9,10)
  • InChiKey: IWWZOWCEMZETEN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[bis(2-hydroxyethylamino)methyleneamino]acetic acid
  • 2-[bis(2-hydroxyethylamino)methylideneamino]ethanoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi jmjC domain containing protein 0.0037 0.0057 0.0057
Mycobacterium ulcerans hypothetical protein 0.0013 0.0003 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0026 0.0032 0.0185
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0232 0.051 0.051
Trypanosoma cruzi Aph-1 protein, putative 0.0096 0.0194 0.0194
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.1722 0.396 0.396
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0053 0.0094 0.055
Echinococcus granulosus histone deacetylase 6 0.0573 0.1298 0.1298
Loa Loa (eye worm) hypothetical protein 0.0053 0.0095 0.0095
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0053 0.0094 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0048 0.0083 0.0083
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0053 0.0094 0.0094
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0052 0.0052
Entamoeba histolytica hypothetical protein, conserved 0.0454 0.1023 0.6015
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.1722 0.396 0.396
Echinococcus multilocularis histone deacetylase 3 0.0747 0.1701 0.1701
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.0315 0.0315
Giardia lamblia Cathepsin B precursor 0.0048 0.0084 0.0491
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0003 0.0003
Loa Loa (eye worm) subtilase 0.0276 0.0612 0.0612
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0454 0.1023 0.1023
Plasmodium falciparum histone deacetylase 1 0.0747 0.1701 1
Leishmania major cathepsin L-like protease 0.0026 0.0032 0.0032
Echinococcus granulosus histone deacetylase 8 0.0295 0.0654 0.0654
Toxoplasma gondii histone deacetylase SIR2 0.0048 0.0083 0.0083
Echinococcus multilocularis Mastin 0.0013 0.0003 0.0003
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0103 0.0211 0.0211
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0017 0.0042
Onchocerca volvulus 0.0099 0.0202 0.0202
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0232 0.051 0.2997
Entamoeba histolytica prolyl oligopeptidase family protein 0.0454 0.1023 0.6015
Toxoplasma gondii kringle domain-containing protein 0.0053 0.0095 0.0095
Plasmodium vivax vivapain-1 0.0015 0.0007 0.0041
Toxoplasma gondii histone deacetylase HDAC3 0.0747 0.1701 0.1701
Trypanosoma brucei histone deacetylase, putative 0.056 0.1269 0.1269
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0053 0.0094 0.0094
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0052 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0015 0.0007 0.0007
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0053 0.0094 0.0094
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0066 0.0066
Schistosoma mansoni cpg binding protein 0.0029 0.0038 0.0038
Brugia malayi Cell death protein 3 precursor 0.0093 0.0186 0.0186
Giardia lamblia Transcriptional regulator, Sir2 family 0.0048 0.0083 0.0485
Trypanosoma cruzi histone deacetylase, putative 0.056 0.1269 0.1269
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0048 0.0083 0.0083
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.1722 0.396 1
Mycobacterium ulcerans hypothetical protein 0.0047 0.0082 0.0206
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0026 0.0032 0.0185
Plasmodium falciparum cysteine proteinase falcipain 3 0.0026 0.0032 0.0185
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0103 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0046 0.0079 0.0079
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0032
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0045 0.0077 0.0077
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0032 0.0185
Brugia malayi NAD-dependent deacetylase SIRT1 0.0153 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Brugia malayi Matrixin family protein 0.0038 0.006 0.006
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0039 0.0231
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.01 0.01
Echinococcus multilocularis enteropeptidase 0.0013 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0032 0.0185
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0454 0.1023 0.1023
Onchocerca volvulus Matrilysin homolog 0.0085 0.0168 0.0168
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0052 0.0052
Loa Loa (eye worm) sirtuin 4 0.0048 0.0083 0.0083
Trypanosoma brucei histone deacetylase 3 0.056 0.1269 0.1269
Onchocerca volvulus 0.0054 0.0097 0.0097
Echinococcus granulosus apoptotic protease activating factor 1 0.0093 0.0186 0.0186
Echinococcus granulosus histone deacetylase 6 0.056 0.1269 0.1269
Brugia malayi transcriptional regulator, Sir2 family protein 0.0048 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0038 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0101 0.0206 0.0206
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0454 0.1023 0.1023
Brugia malayi Cathepsin L-like precursor 0.0019 0.0015 0.0015
Brugia malayi hypothetical protein 0.0013 0.0003 0.0003
Mycobacterium tuberculosis Probable oxidoreductase 0.082 0.1871 0.2077
Plasmodium falciparum cysteine proteinase falcipain 1 0.0015 0.0007 0.0041
Brugia malayi Matrixin family protein 0.0092 0.0185 0.0185
Onchocerca volvulus Deterin homolog 0.0234 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Schistosoma mansoni histone deacetylase 4 5 0.056 0.1269 0.1269
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0138 0.0292 0.0292
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0015 0.0087
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0053 0.0053
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.004 0.0065 0.0065
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0234 0.0512 0.0512
Brugia malayi histone deacetylase 11 0.0295 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0024
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0747 0.1701 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0057 0.0057
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0083 0.0486
Brugia malayi hypothetical protein 0.0093 0.0186 0.0186
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0032 0.0185
Entamoeba histolytica cysteine protease, putative 0.0015 0.0007 0.0041
Loa Loa (eye worm) hypothetical protein 0.0148 0.0315 0.0315
Plasmodium falciparum histone deacetylase, putative 0.056 0.1269 0.746
Leishmania major histone deacetylase, putative 0.056 0.1269 0.1269
Schistosoma mansoni hypothetical protein 0.0047 0.008 0.008
Echinococcus multilocularis GPCR, family 2 0.0047 0.008 0.008
Giardia lamblia Histone deacetylase 0.0747 0.1701 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0047 0.0082 0.048
Onchocerca volvulus 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0024
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0083 0.0486
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0042 0.0042
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0032 0.0032
Toxoplasma gondii exonuclease III APE 0.0019 0.0017 0.0017
Trypanosoma cruzi aminopeptidase, putative 0.0035 0.0052 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0082 0.0082
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0153 0.0327 0.0327
Entamoeba histolytica prolyl oligopeptidase family protein 0.0454 0.1023 0.6015
Trypanosoma brucei prolyl oligopeptidase, putative 0.1722 0.396 0.396
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0012 0 0.0001
Trypanosoma cruzi Aminopeptidase M1, putative 0.0035 0.0052 0.0052
Echinococcus granulosus inhibitor of apoptosis protein 0.0234 0.0512 0.0512
Schistosoma mansoni cpg binding protein 0.003 0.0042 0.0042
Leishmania major oligopeptidase b 0.1722 0.396 0.396
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0026 0.0032 0.0185
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0024
Onchocerca volvulus Prolyl endopeptidase homolog 0.4331 1 1
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0015
Schistosoma mansoni immunophilin 0.0053 0.0094 0.0094
Entamoeba histolytica cysteine protease, putative 0.0015 0.0007 0.0041
Echinococcus multilocularis cathepsin b 0.0138 0.0292 0.0292
Trichomonas vaginalis histone deacetylase, putative 0.0747 0.1701 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0048 0.0083 0.0083
Schistosoma mansoni cathepsin D (A01 family) 0.0105 0.0215 0.0215
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0042 0.0042
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0052 0.0052
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0138 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.0454 0.1023 0.1023
Schistosoma mansoni hypothetical protein 0.0013 0.0003 0.0003
Plasmodium falciparum histone deacetylase 2 0.056 0.1269 0.746
Echinococcus multilocularis histone deacetylase 6 0.056 0.1269 0.1269
Brugia malayi Peptidase family M1 containing protein 0.0035 0.0052 0.0052
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0052 0.0052
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0138 0.0292 0.0292
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0032 0.0185
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0003 0.0003
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0138 0.0292 0.0292
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0042 0.0042
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0039 0.0039
Echinococcus granulosus dnaJ subfamily B 0.0409 0.0919 0.0919
Leishmania major histone deacetylase, putative 0.0747 0.1701 0.1701
Trichomonas vaginalis histone deacetylase, putative 0.0747 0.1701 1
Schistosoma mansoni cpg binding protein 0.003 0.0042 0.0042
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0052 0.0052
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0013 0.0003 0.0003
Echinococcus multilocularis fk506 binding protein 0.0053 0.0094 0.0094
Schistosoma mansoni histone deacetylase 1 2 3 0.0295 0.0654 0.0654
Loa Loa (eye worm) transcriptional regulator 0.0048 0.0083 0.0083
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0099 0.0202 0.0202
Echinococcus multilocularis cysteine protease 0.0026 0.0032 0.0032
Trypanosoma cruzi cysteine peptidase, putative 0.0015 0.0007 0.0007
Trypanosoma cruzi histone deacetylase, putative 0.056 0.1269 0.1269
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0032 0.0185
Toxoplasma gondii histone deacetylase HDAC1 0.056 0.1269 0.1269
Loa Loa (eye worm) hypothetical protein 0.0093 0.0186 0.0186
Mycobacterium ulcerans short chain dehydrogenase 0.082 0.1871 0.4726
Echinococcus multilocularis tissue type plasminogen activator 0.0053 0.0095 0.0095
Brugia malayi transcriptional regulator, Sir2 family protein 0.0048 0.0083 0.0083
Echinococcus multilocularis gamma secretase subunit aph 1 0.0246 0.0541 0.0541
Brugia malayi Pre-SET motif family protein 0.0209 0.0455 0.0455
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0053 0.0094 0.055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0032 0.0185
Leishmania major cathepsin L-like protease 0.0026 0.0032 0.0032
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0153 0.0327 0.1921
Trypanosoma cruzi Aph-1 protein, putative 0.0096 0.0194 0.0194
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0003 0.0003
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0015
Schistosoma mansoni immunophilin 0.0053 0.0094 0.0094
Trichomonas vaginalis histone deacetylase, putative 0.0747 0.1701 1
Onchocerca volvulus 0.0093 0.0186 0.0186
Loa Loa (eye worm) fibroinase 0.0026 0.0032 0.0032
Trichomonas vaginalis set domain proteins, putative 0.0238 0.0522 0.3068
Loa Loa (eye worm) hypothetical protein 0.0153 0.0327 0.0327
Giardia lamblia Alanyl dipeptidyl peptidase 0.0454 0.1023 0.6015
Echinococcus multilocularis cathepsin L cysteine protease 0.0026 0.0032 0.0032
Schistosoma mansoni chromatin regulatory protein sir2 0.0232 0.051 0.051
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0042 0.0042
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0057 0.0057
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0003 0.0003
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0147 0.0147
Echinococcus granulosus prolyl endopeptidase 0.4331 1 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.0094 0.0094
Onchocerca volvulus Matrix metalloproteinase homolog 0.0085 0.0168 0.0168
Toxoplasma gondii histone deacetylase HDAC4 0.0295 0.0654 0.0654
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0032 0.0032
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0012 0 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0082 0.0082
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0138 0.0292 0.0292
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0032 0.0032
Brugia malayi Protein kinase domain containing protein 0.0053 0.0095 0.0095
Brugia malayi Latrophilin receptor protein 2 0.0047 0.008 0.008
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0032 0.0032
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0099 0.0202 0.0202
Brugia malayi histone deacetylase 3 (HD3) 0.0747 0.1701 0.1701
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0234 0.0512 0.0512
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0017 0.0017
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0139 0.0293 0.0293
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0035 0.0052 0.0052
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.3877 0.8948 1
Leishmania major hypothetical protein, conserved 0.0053 0.0095 0.0095
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0193 0.0193
Loa Loa (eye worm) matrix metalloproteinase 0.0038 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0029 0.0039 0.0039
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0454 0.1023 0.1023
Loa Loa (eye worm) hypothetical protein 0.0234 0.0512 0.0512
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0232 0.051 0.051
Brugia malayi gamma-secretase subunit aph-1 0.0246 0.0541 0.0541
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0017 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0032 0.0032
Echinococcus granulosus cathepsin l cysteine peptidase 0.0026 0.0032 0.0032
Schistosoma mansoni chromatin regulatory protein sir2 0.0232 0.051 0.051
Brugia malayi Cathepsin L-like precursor 0.0026 0.0032 0.0032
Schistosoma mansoni histone deacetylase 0.0747 0.1701 0.1701
Mycobacterium ulcerans Sir2-like regulatory protein 0.0048 0.0083 0.0209
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0012 0 0.0001
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.4331 1 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.0654 0.0654
Schistosoma mansoni immunophilin 0.0045 0.0077 0.0077
Brugia malayi PHD-finger family protein 0.0029 0.0039 0.0039
Onchocerca volvulus 0.0038 0.006 0.006
Echinococcus granulosus histone deacetylase 1 0.0747 0.1701 0.1701
Trypanosoma brucei oligopeptidase b 0.1722 0.396 0.396
Plasmodium vivax hypothetical protein, conserved 0.0454 0.1023 0.6015
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0035 0.0052 0.0052
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0153 0.0327 0.1922
Entamoeba histolytica cysteine protease, putative 0.0015 0.0007 0.0041
Loa Loa (eye worm) hypothetical protein 0.003 0.0042 0.0042
Onchocerca volvulus 0.0019 0.0015 0.0015
Onchocerca volvulus 0.0086 0.0171 0.0171
Onchocerca volvulus 0.0026 0.0032 0.0032
Echinococcus multilocularis peregrin 0.0029 0.0039 0.0039
Brugia malayi jmjC domain containing protein 0.0096 0.0193 0.0193
Echinococcus granulosus cathepsin l1 0.0019 0.0015 0.0015
Echinococcus granulosus histone deacetylase 3 0.0747 0.1701 0.1701
Echinococcus multilocularis aminopeptidase N 0.0035 0.0052 0.0052
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0053 0.0094 0.055
Giardia lamblia PHD finger protein 15 0.0029 0.0039 0.023
Plasmodium vivax hypothetical protein, conserved 0.0012 0 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0032 0.0185
Trichomonas vaginalis immunophilin, putative 0.0053 0.0094 0.055
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0053 0.0094 0.0094
Treponema pallidum mcbG protein 0.0047 0.0082 0.8439
Onchocerca volvulus 0.0029 0.0038 0.0038
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0234 0.0512 0.0512
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0038 0.0038
Loa Loa (eye worm) prolyl oligopeptidase 0.0454 0.1023 0.1023
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0032 0.0032
Mycobacterium ulcerans aminopeptidase N PepN 0.0035 0.0052 0.0132
Schistosoma mansoni hypothetical protein 0.0029 0.0039 0.0039
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0003 0.0003
Brugia malayi Cathepsin L-like precursor 0.0026 0.0032 0.0032
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.0007 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0045 0.0077 0.0077
Schistosoma mansoni chromatin regulatory protein sir2 0.0048 0.0083 0.0083
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0013 0.0003 0.0003
Entamoeba histolytica cysteine protease, putative 0.0015 0.0007 0.0041
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0007 0.0041
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0013 0.0003 0.0003
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0083 0.0486
Loa Loa (eye worm) cysteine protease 0.0026 0.0032 0.0032
Echinococcus granulosus transmembrane protease serine 3 0.0013 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0032 0.0185
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0084 0.0084
Echinococcus granulosus histone deacetylase 6 0.056 0.1269 0.1269
Plasmodium vivax vivapain-2 0.0026 0.0032 0.0185
Echinococcus multilocularis cysteine protease 0.0026 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0007 0.0041
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Onchocerca volvulus Cathepsin L homolog 0.0026 0.0032 0.0032
Toxoplasma gondii histone deacetylase SIR2-like 0.0048 0.0083 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0015 0.0087
Loa Loa (eye worm) hypothetical protein 0.0038 0.006 0.006
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0048 0.0083 0.0486
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0053 0.0095 0.0556
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0032 0.0185
Leishmania major cathepsin L-like protease 0.0026 0.0032 0.0032
Brugia malayi Histone deacetylase 1 0.0747 0.1701 0.1701
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0048 0.0083 0.0083
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0026 0.0032 0.0032
Brugia malayi cathepsin L-like precursor 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0038 0.006 0.006
Trypanosoma cruzi histone deacetylase 1, putative 0.0747 0.1701 0.1701
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0012 0 0.0001
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0232 0.051 0.051
Loa Loa (eye worm) TK/ROR protein kinase 0.0053 0.0095 0.0095
Echinococcus multilocularis histone deacetylase 7 0.056 0.1269 0.1269
Echinococcus granulosus histone deacetylase 7 0.056 0.1269 0.1269
Entamoeba histolytica cysteine protease, putative 0.0026 0.0032 0.0185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0032 0.0185
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0053 0.0094 0.0094
Echinococcus multilocularis apoptotic protease activating factor 1 0.0093 0.0186 0.0186
Schistosoma mansoni chromatin regulatory protein sir2 0.0048 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0245 0.0538 0.3164
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0026 0.0032 0.0032
Plasmodium vivax SET domain protein, putative 0.003 0.0042 0.0249
Schistosoma mansoni hypothetical protein 0.0047 0.008 0.008
Trypanosoma cruzi histone deacetylase, putative 0.0295 0.0654 0.0654
Giardia lamblia Cathepsin B precursor 0.0048 0.0084 0.0491
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0042 0.0042
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.1722 0.396 0.396
Loa Loa (eye worm) hypothetical protein 0.0047 0.008 0.008
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0007 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0032 0.0185
Loa Loa (eye worm) histone deacetylase 11 0.0295 0.0654 0.0654
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1611 0.3703 0.3703
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0026 0.0032 0.0185
Echinococcus granulosus cysteine protease 0.0015 0.0007 0.0007
Trypanosoma cruzi cysteine proteinase, putative 0.0015 0.0007 0.0007
Echinococcus granulosus Mastin 0.0013 0.0003 0.0003
Onchocerca volvulus Cathepsin L homolog 0.0026 0.0032 0.0032
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0003 0.0003
Trypanosoma brucei SIR2-like protein 4, putative 0.0048 0.0083 0.0083
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0042 0.0042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0015 0.0007 0.0007
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0454 0.1023 0.1023
Entamoeba histolytica cysteine protease, putative 0.0015 0.0007 0.0041
Onchocerca volvulus 0.0035 0.0052 0.0052
Echinococcus granulosus cathepsin L cysteine protease 0.0015 0.0007 0.0007
Echinococcus multilocularis caspase 2 0.0093 0.0186 0.0186
Trypanosoma brucei Aminopeptidase M1, putative 0.0035 0.0052 0.0052
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0454 0.1023 0.6015
Echinococcus granulosus cathepsin L cysteine proteinase 0.0026 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.4331 1 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0747 0.1701 1
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0012 0 0.0001
Brugia malayi Hemopexin family protein 0.0054 0.0097 0.0097
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0052 0.0052
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0003 0.0003
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0017 0.0017
Leishmania major sir2-family protein-like protein 0.0048 0.0083 0.0083
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0003 0.0003
Trypanosoma brucei prolyl endopeptidase 0.4331 1 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0454 0.1023 0.6015
Entamoeba histolytica cysteine protease, putative 0.0015 0.0007 0.0041
Toxoplasma gondii hypothetical protein 0.0454 0.1023 0.1023
Plasmodium vivax aspartyl protease, putative 0.0092 0.0184 0.1081
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0017 0.0097
Leishmania major cathepsin L-like protease 0.0026 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0454 0.1023 0.1023
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0017 0.0097
Loa Loa (eye worm) hypothetical protein 0.0106 0.0216 0.0216
Schistosoma mansoni histone deacetylase 0.0747 0.1701 0.1701
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.0007 0.0007
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0042 0.0042
Brugia malayi Kringle domain containing protein 0.0053 0.0095 0.0095
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0057 0.0057
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0032 0.0032
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0012 0 0.0001
Leishmania major silent information regulator 2, putative 0.0232 0.051 0.051
Onchocerca volvulus 0.0013 0.0003 0.0003
Onchocerca volvulus 0.003 0.0042 0.0042
Echinococcus multilocularis acylamino acid releasing enzyme 0.0454 0.1023 0.1023
Giardia lamblia Hypothetical protein 0.0232 0.051 0.2997
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0017 0.0097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0032 0.0032
Schistosoma mansoni cathepsin D (A01 family) 0.0105 0.0215 0.0215
Giardia lamblia Alanyl dipeptidyl peptidase 0.0454 0.1023 0.6015
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0035 0.0052 0.0307
Plasmodium falciparum peptidase, putative 0.0454 0.1023 0.6015
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0053 0.0094 0.055
Echinococcus granulosus geminin 0.0334 0.0745 0.0745
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0032 0.0032
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0099 0.0202 0.0202
Echinococcus granulosus cathepsin b 0.0138 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Toxoplasma gondii prolyl endopeptidase 0.4331 1 1
Leishmania major cathepsin L-like protease 0.0026 0.0032 0.0032
Echinococcus granulosus Dipeptidyl peptidase 9 0.0454 0.1023 0.1023
Echinococcus multilocularis cathepsin b 0.0138 0.0292 0.0292
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0023 0.0024 0.0024
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.0047 0.008 0.008
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.4331 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0032 0.0185
Echinococcus multilocularis prolyl endopeptidase 0.4331 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0032 0.0185
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0038 0.0038
Echinococcus granulosus caspase 2 0.0093 0.0186 0.0186
Plasmodium falciparum cysteine repeat modular protein 1 0.0053 0.0095 0.0556
Brugia malayi Histone deacetylase family protein 0.056 0.1269 0.1269
Echinococcus granulosus acylamino acid releasing enzyme 0.0454 0.1023 0.1023
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0454 0.1023 0.6015
Leishmania major peptidylprolyl isomerase-like protein 0.0053 0.0094 0.0094
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0454 0.1023 0.1023
Brugia malayi Histone deacetylase family protein 0.056 0.1269 0.1269
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.0094 0.0094
Trypanosoma brucei Aminopeptidase M1, putative 0.0035 0.0052 0.0052
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0023 0.0024 0.0024
Trypanosoma brucei Aph-1 protein, putative 0.0096 0.0194 0.0194
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0045 0.0077 0.0077
Echinococcus granulosus cpg binding protein 0.003 0.0042 0.0042
Echinococcus granulosus glycoprotein Antigen 5 0.0013 0.0003 0.0003
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0048 0.0083 0.0083
Schistosoma mansoni histone deacetylase 4 5 0.056 0.1269 0.1269
Mycobacterium tuberculosis Conserved protein 0.0047 0.0082 0.0073
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0013 0.0003 0.0003
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0007 0.0041
Brugia malayi Trypsin family protein 0.0099 0.0202 0.0202
Echinococcus multilocularis histone deacetylase 0.056 0.1269 0.1269
Mycobacterium ulcerans hydrolase 0.0046 0.0079 0.02
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.008 0.008
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0048 0.0083 0.0485
Toxoplasma gondii cathepsin B 0.0048 0.0084 0.0084
Brugia malayi prolyl oligopeptidase family protein 0.0454 0.1023 0.1023
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0015 0.0015
Trichomonas vaginalis histone deacetylase, putative 0.0747 0.1701 1
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0012 0 0.0001
Brugia malayi Trypsin family protein 0.0013 0.0003 0.0003
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0048 0.0083 0.0486
Trypanosoma cruzi hypothetical protein, conserved 0.0454 0.1023 0.1023
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0232 0.051 0.051
Trypanosoma cruzi prolyl endopeptidase 0.4331 1 1
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0048 0.0083 0.0074
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0042 0.0042
Schistosoma mansoni gamma-secretase subunit aph-1 0.0246 0.0541 0.0541
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0017 0.0017
Echinococcus granulosus chromatin regulatory protein sir2 0.0232 0.051 0.051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0032 0.0185
Echinococcus multilocularis inhibitor of apoptosis protein 0.0234 0.0512 0.0512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0032 0.0185
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0046 0.0079 0.007
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0035 0.0052 0.0052
Echinococcus granulosus gamma secretase subunit aph 1 0.0246 0.0541 0.0541
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0023 0.0024 0.0024
Echinococcus granulosus cathepsin l1 0.0026 0.0032 0.0032
Trypanosoma cruzi oligopeptidase b 0.1722 0.396 0.396
Brugia malayi prolyl oligopeptidase family protein 0.0454 0.1023 0.1023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0032 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0012 0 0.0001
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0153 0.0327 0.1922
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0032 0.0185
Onchocerca volvulus 0.0234 0.0512 0.0512
Trichomonas vaginalis fk506-binding protein, putative 0.0053 0.0094 0.055
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0017 0.0097
Echinococcus granulosus GPCR family 2 0.0047 0.008 0.008
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.0094 0.0094
Toxoplasma gondii histone deacetylase HDAC5 0.0295 0.0654 0.0654
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0048 0.0084 0.0491
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0048 0.0083 0.0083
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0232 0.051 0.2998
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0015 0.0087
Entamoeba histolytica cysteine protease, putative 0.0015 0.0007 0.0041
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0083 0.0485
Loa Loa (eye worm) histone deacetylase 0.056 0.1269 0.1269
Trichomonas vaginalis histone deacetylase, putative 0.0747 0.1701 1
Schistosoma mansoni hypothetical protein 0.0093 0.0186 0.0186
Plasmodium vivax vivapain-2 0.0026 0.0032 0.0185
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0003 0.0003
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0053 0.0094 0.0094
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0032 0.0185
Schistosoma mansoni hypothetical protein 0.0047 0.008 0.008
Trypanosoma cruzi cruzipain precursor, putative 0.0026 0.0032 0.0032
Plasmodium vivax histone deacetylase 1, putative 0.0747 0.1701 1
Toxoplasma gondii cathepsin CPL 0.0026 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0032 0.0185
Trypanosoma cruzi hypothetical protein, conserved 0.0454 0.1023 0.1023
Onchocerca volvulus 0.0035 0.0052 0.0052
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0278 0.0615 0.0615
Schistosoma mansoni ap endonuclease 0.0019 0.0017 0.0017
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0053 0.0094 0.0236
Trypanosoma cruzi cysteine proteinase, putative 0.0015 0.0007 0.0007
Echinococcus multilocularis histone deacetylase 8 0.0295 0.0654 0.0654
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0012 0 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0007 0.0041
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0206 0.0206
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0017 0.0097
Brugia malayi Cathepsin L-like precursor 0.0026 0.0032 0.0032
Onchocerca volvulus Matrilysin homolog 0.0038 0.006 0.006
Leishmania major histone deacetylase, putative 0.0747 0.1701 0.1701
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0048 0.0083 0.0083
Brugia malayi Bromodomain containing protein 0.0029 0.0039 0.0039
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0115 0.0115
Echinococcus granulosus cathepsin b 0.0138 0.0292 0.0292
Entamoeba histolytica cysteine protease, putative 0.0015 0.0007 0.0041
Echinococcus multilocularis chromatin regulatory protein sir2 0.0232 0.051 0.051
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0012 0 0.0001
Loa Loa (eye worm) matrixin family protein 0.0085 0.0168 0.0168
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.0053 0.0095 0.0095
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0153 0.0327 0.1922
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0153 0.0327 0.0327
Giardia lamblia Sirtuin type 2 0.0048 0.0083 0.0485
Brugia malayi Matrixin family protein 0.0038 0.006 0.006
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0003 0.0003
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0039 0.0039
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0003 0.0003
Entamoeba histolytica cysteine protease, putative 0.0015 0.0007 0.0041
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0193 0.0193
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.008 0.008
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0046 0.0079 0.0079
Entamoeba histolytica cysteine proteinase 2 0.0015 0.0007 0.0041
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0032 0.0032
Echinococcus granulosus enteropeptidase 0.0013 0.0003 0.0003
Trypanosoma cruzi histone deacetylase, putative 0.056 0.1269 0.1269
Loa Loa (eye worm) prolyl oligopeptidase 0.0454 0.1023 0.1023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0032 0.0185
Trypanosoma brucei histone deacetylase 4 0.056 0.1269 0.1269
Mycobacterium tuberculosis Probable peptidase 0.1722 0.396 0.4415
Schistosoma mansoni inhibitor of apoptosis protein 0.0234 0.0512 0.0512
Plasmodium falciparum plasmepsin X 0.0092 0.0184 0.1081
Loa Loa (eye worm) hypothetical protein 0.0234 0.0512 0.0512
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0153 0.0327 0.1922
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.0095 0.0095
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0048 0.0084 0.0084
Loa Loa (eye worm) matrixin family protein 0.0092 0.0185 0.0185
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0013 0.0013
Leishmania major cysteine peptidase A (CPA) 0.0026 0.0032 0.0032
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0083 0.0486
Entamoeba histolytica cysteine protease, putative 0.0015 0.0007 0.0041
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0035 0.0052 0.0052
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.0094 0.0094
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0026 0.0032 0.0032
Trypanosoma cruzi histone deacetylase, putative 0.0295 0.0654 0.0654
Entamoeba histolytica cysteine protease, putative 0.0015 0.0007 0.0041
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0003 0.0003
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0039 0.0039
Entamoeba histolytica cysteine proteinase 1, putative 0.0015 0.0007 0.0041
Echinococcus multilocularis cathepsin L cysteine protease 0.0026 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0054 0.0097 0.0097
Brugia malayi Pre-SET motif family protein 0.003 0.0042 0.0042
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0454 0.1023 0.6015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0032 0.0185
Loa Loa (eye worm) aminopeptidase N 0.0035 0.0052 0.0052
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0015 0.0007 0.0007
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0052 0.0052
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0747 0.1701 1
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0454 0.1023 0.1023
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0246 0.0541 0.0541
Leishmania major histone deacetylase, putative 0.056 0.1269 0.1269
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0003 0.0003
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0035 0.0052 0.0052
Loa Loa (eye worm) trypsin family protein 0.0013 0.0003 0.0003
Plasmodium vivax vivapain-3 0.0015 0.0007 0.0041
Brugia malayi Matrixin family protein 0.0038 0.006 0.006
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0454 0.1023 0.1023
Plasmodium vivax aspartyl protease, putative 0.0092 0.0184 0.1081
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0234 0.0512 0.0512
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.4331 1 1
Leishmania major cathepsin L-like protease 0.0026 0.0032 0.0032
Echinococcus multilocularis transmembrane protease serine 3 0.0013 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0234 0.0512 0.0512
Trypanosoma brucei histone deacetylase 1 0.0747 0.1701 0.1701
Schistosoma mansoni histone deacetylase hda2 0.0573 0.1298 0.1298
Loa Loa (eye worm) hypothetical protein 0.0266 0.0587 0.0587
Onchocerca volvulus 0.0026 0.0032 0.0032
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0276 0.0612 0.0612
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0454 0.1023 0.6015
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.0919 0.0919
Onchocerca volvulus Cathepsin F homolog 0.0026 0.0032 0.0032
Brugia malayi CXXC zinc finger family protein 0.0029 0.0038 0.0038
Trypanosoma cruzi cysteine protease, putative 0.0015 0.0007 0.0007
Brugia malayi Trypsin family protein 0.0013 0.0003 0.0003
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0039 0.0039
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0032 0.0185
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0003 0.0003
Brugia malayi hypothetical protein 0.0035 0.0052 0.0052
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.008 0.008
Entamoeba histolytica aminopeptidase, putative 0.0035 0.0052 0.0306
Schistosoma mansoni histone deacetylase hda2 0.0295 0.0654 0.0654
Brugia malayi histone deacetylase 1 (HD1) 0.0747 0.1701 0.1701
Leishmania major cathepsin L-like protease 0.0026 0.0032 0.0032
Brugia malayi Cathepsin L-like cysteine proteinase 0.0019 0.0015 0.0015
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0334 0.0745 0.0745
Onchocerca volvulus 0.0053 0.0095 0.0095
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0048 0.0083 0.0083
Leishmania major hypothetical protein, conserved 0.0047 0.0082 0.0082
Trichomonas vaginalis BRCA1-associated protein, putative 0.0012 0 0.0001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.008 0.008
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0007 0.0041
Brugia malayi transcriptional regulator, Sir2 family protein 0.0232 0.051 0.051
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0017 0.0017
Onchocerca volvulus 0.0026 0.0032 0.0032
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0454 0.1023 0.1023
Brugia malayi Cathepsin L-like precursor 0.0026 0.0032 0.0032
Echinococcus multilocularis histone deacetylase 1 0.0747 0.1701 0.1701
Leishmania major fk506-binding protein 1-like protein 0.0053 0.0094 0.0094
Loa Loa (eye worm) transcriptional regulator 0.0232 0.051 0.051
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0232 0.051 0.051
Loa Loa (eye worm) transcriptional regulator 0.0048 0.0083 0.0083
Onchocerca volvulus Alhambra homolog 0.0029 0.0039 0.0039
Onchocerca volvulus 0.0238 0.0522 0.0522
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0052 0.0052
Schistosoma mansoni chromatin regulatory protein sir2 0.0232 0.051 0.051
Schistosoma mansoni chromatin regulatory protein sir2 0.0153 0.0327 0.0327
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0039 0.0039
Echinococcus multilocularis cpg binding protein 0.003 0.0042 0.0042
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0019 0.0015 0.0015
Toxoplasma gondii aspartyl protease ASP3 0.0092 0.0184 0.0184
Trichomonas vaginalis brca1-associated protein, putative 0.0012 0 0.0001
Brugia malayi Trypsin family protein 0.0013 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0334 0.0745 0.0745
Onchocerca volvulus 0.0013 0.0003 0.0003
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0138 0.0292 0.0292
Toxoplasma gondii histone deacetylase HDAC2 0.0747 0.1701 0.1701
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0048 0.0083 0.0083
Loa Loa (eye worm) histone deacetylase 3 0.0747 0.1701 0.1701
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.008 0.008
Onchocerca volvulus Histone deacetylase 10 homolog 0.0295 0.0654 0.0654
Echinococcus granulosus tissue type plasminogen activator 0.0053 0.0095 0.0095
Echinococcus granulosus aminopeptidase N 0.0035 0.0052 0.0052
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0053 0.0094 0.055
Loa Loa (eye worm) hypothetical protein 0.0099 0.0202 0.0202
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0234 0.0512 0.0512
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0083 0.0486
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0032 0.0185
Schistosoma mansoni hypothetical protein 0.0101 0.0206 0.0206
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0454 0.1023 0.1023
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0057 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0032 0.0032
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0017 0.5
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0053 0.0094 0.055
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.1722 0.396 0.396
Loa Loa (eye worm) FKBP5 protein 0.0053 0.0094 0.0094
Entamoeba histolytica cysteine protease, putative 0.0015 0.0007 0.0041
Echinococcus granulosus peregrin 0.0029 0.0039 0.0039
Entamoeba histolytica cysteine protease, putative 0.0015 0.0007 0.0041
Giardia lamblia Cathepsin B precursor 0.0048 0.0084 0.0491
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0013 0.0003 0.0003
Onchocerca volvulus 0.0026 0.0032 0.0032
Brugia malayi Cathepsin L-like precursor 0.0026 0.0032 0.0032
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0048 0.0084 0.0084
Brugia malayi Trypsin-like protease protein 5 0.0013 0.0003 0.0003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.0315 0.0315
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0454 0.1023 0.1023
Brugia malayi Peptidase family M1 containing protein 0.0035 0.0052 0.0052
Schistosoma mansoni ap endonuclease 0.0019 0.0017 0.0017
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.1722 0.396 1
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0053 0.0094 0.055
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.0315 0.0315
Echinococcus granulosus cathepsin L 0.0015 0.0007 0.0007
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.0007 0.0007
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0454 0.1023 0.1023
Loa Loa (eye worm) ctsf protein 0.0026 0.0032 0.0032
Trypanosoma cruzi histone deacetylase 1, putative 0.0747 0.1701 0.1701
Leishmania major cathepsin L-like protease 0.0026 0.0032 0.0032
Plasmodium falciparum plasmepsin IX 0.0092 0.0184 0.1081
Leishmania major hypothetical protein, conserved 0.0047 0.0082 0.0082
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0454 0.1023 0.1023
Brugia malayi Subtilase family protein 0.0276 0.0612 0.0612
Loa Loa (eye worm) cathepsin B 0.0048 0.0084 0.0084
Echinococcus multilocularis cathepsin L 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0088
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0035 0.0052 0.0307
Trichomonas vaginalis conserved hypothetical protein 0.0454 0.1023 0.6015
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0139 0.0293 0.0293
Loa Loa (eye worm) histone deacetylase 7A 0.056 0.1269 0.1269
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0053 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0747 0.1701 0.1701
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0017 0.0097
Onchocerca volvulus 0.0026 0.0032 0.0032
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0053 0.0094 0.055
Onchocerca volvulus Cell death protein 3 homolog 0.0093 0.0186 0.0186
Mycobacterium ulcerans NAD-dependent deacetylase 0.0048 0.0083 0.0209
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0454 0.1023 0.1023
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0032 0.0185
Loa Loa (eye worm) hypothetical protein 0.0093 0.0186 0.0186
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.008 0.008
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0026 0.0032 0.0032
Plasmodium falciparum phd finger protein, putative 0.0029 0.0039 0.0231
Plasmodium vivax NAD-dependent deacetylase, putative 0.0048 0.0083 0.0486
Brugia malayi Cathepsin L-like precursor 0.0026 0.0032 0.0032
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0038 0.006 0.006
Trichomonas vaginalis histone deacetylase, putative 0.0747 0.1701 1
Plasmodium vivax histone deacetylase, putative 0.056 0.1269 0.746
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.1722 0.396 0.4415
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0232 0.051 0.2998
Brugia malayi prolyl oligopeptidase family protein 0.0454 0.1023 0.1023
Schistosoma mansoni hypothetical protein 0.0409 0.0919 0.0919
Trypanosoma cruzi oligopeptidase b 0.1722 0.396 0.396
Brugia malayi cathepsin B-like cysteine proteinase 0.0138 0.0292 0.0292
Brugia malayi Matrixin family protein 0.0038 0.006 0.006
Loa Loa (eye worm) histone deacetylase 1 0.0747 0.1701 0.1701
Schistosoma mansoni caspase-7 (C14 family) 0.0093 0.0186 0.0186
Echinococcus multilocularis histone deacetylase 6 0.056 0.1269 0.1269
Plasmodium vivax histone deacetylase 2, putative 0.056 0.1269 0.746
Trypanosoma brucei cysteine peptidase C (CPC) 0.0048 0.0084 0.0084
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.0455 0.0455
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0048 0.0083 0.0083
Onchocerca volvulus 0.0026 0.0032 0.0032
Brugia malayi prolyl oligopeptidase family protein 0.0454 0.1023 0.1023
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0032 0.0185
Echinococcus granulosus histone deacetylase 0.056 0.1269 0.1269
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0454 0.1023 0.1023
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0048 0.0083 0.0485
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0032 0.0032
Onchocerca volvulus 0.0026 0.0032 0.0032
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0039 0.0039
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0454 0.1023 0.1023
Echinococcus multilocularis histone deacetylase 6 0.0573 0.1298 0.1298
Plasmodium vivax histone deacetylase, putative 0.0295 0.0654 0.3845
Entamoeba histolytica histone deacetylase, putative 0.0747 0.1701 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0035 0.0052 0.0052
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0083 0.0486
Echinococcus multilocularis glycoprotein Antigen 5 0.0013 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0032 0.0185
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0017 0.0017
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0003 0.0003
Onchocerca volvulus 0.0013 0.0003 0.0003
Trypanosoma brucei histone deacetylase 2 0.0295 0.0654 0.0654
Echinococcus multilocularis geminin 0.0334 0.0745 0.0745
Onchocerca volvulus 0.0013 0.0003 0.0003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0017 0.0017
Plasmodium vivax unspecified product 0.0015 0.0007 0.0041
Brugia malayi Cathepsin L-like precursor 0.0019 0.0015 0.0015

Activities

Activity type Activity value Assay description Source Reference
MISS T/C (functional) = 1.07 In vivo blood glucose was determined in obese, hyperglycemic, hyperinsulinemic, insulin-resistant KKAy mice after a dose of 500 mg/kg for 4 days ChEMBL. 11312923

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.