Detailed information for compound 259547

Basic information

Technical information
  • TDR Targets ID: 259547
  • Name: 3-chloropropyl sulfamate
  • MW: 173.619 | Formula: C3H8ClNO3S
  • H donors: 1 H acceptors: 2 LogP: -0.08 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCCCOS(=O)(=O)N
  • InChi: 1S/C3H8ClNO3S/c4-2-1-3-8-9(5,6)7/h1-3H2,(H2,5,6,7)
  • InChiKey: UKDMPBWGULHLIR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • sulfamic acid 3-chloropropyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens carbonic anhydrase IX Starlite/ChEMBL References
Homo sapiens carbonic anhydrase I Starlite/ChEMBL References
Homo sapiens carbonic anhydrase II Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus granulosus carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania major carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus multilocularis carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania braziliensis carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania infantum carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei gambiense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) carbonic anhydrase 3 Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Putative carbonic anhydrase 5 precursor Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania mexicana carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania donovani carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Eukaryotic-type carbonic anhydrase family protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei carbonic anhydrase-like protein carbonic anhydrase I 261 aa 281 aa 25.3 %
Brugia malayi Carbonic anhydrase like protein 2 precursor carbonic anhydrase II 260 aa 259 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cpg binding protein 0.0124 0.0673 0.0665
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0318 0.0309
Echinococcus multilocularis geminin 0.0164 0.0919 0.0875
Echinococcus multilocularis carbonic anhydrase II 0.0214 0.1222 0.118
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0318 0.0271
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0031 0.0116 0.0068
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0056 0.0008
Loa Loa (eye worm) hypothetical protein 0.0145 0.0801 0.1866
Schistosoma mansoni hypothetical protein 0.0042 0.0178 0.0169
Trichomonas vaginalis esterase, putative 0.0035 0.0137 0.0335
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0286 0.0571
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0137 0.0549
Schistosoma mansoni rac gtpase activating protein 0.0075 0.0381 0.0372
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0324 0.0666
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0397 0.0912
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0286 0.1563
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0316 0.0664
Onchocerca volvulus 0.0022 0.0056 0.0028
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0318 0.0716
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0032 0.0121 0.0074
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0049 0.0222 0.1813
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0101 0.0535 0.1205
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.022
Entamoeba histolytica acyl-coA synthetase, putative 0.0073 0.0369 0.0882
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0049 0.0222 0.0175
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0121 0.0655 0.0611
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0039 0.0159 0.0111
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0369 0.2127
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0204 0.1159 0.275
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0056 0.002
Echinococcus multilocularis cpg binding protein 0.0124 0.0673 0.0629
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0316 0.0269
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0137 0.022
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0056 0.0457
Schistosoma mansoni microtubule-associated protein tau 0.1383 0.829 0.8288
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0688 0.4087 1
Brugia malayi TAR-binding protein 0.0065 0.0318 0.0716
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0369 0.0882
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0294 0.1701 0.4093
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0222 0.1813
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0038 0.0154 0.1259
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0214 0.1222 0.1214
Schistosoma mansoni carbonic anhydrase-related 0.0101 0.0535 0.0526
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0635 0.1453
Loa Loa (eye worm) hypothetical protein 0.0065 0.0318 0.067
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0369 0.0843
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0286 0.2008
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0089 0.0218
Loa Loa (eye worm) RNA binding protein 0.0065 0.0318 0.0668
Schistosoma mansoni carbonic anhydrase-related 0.0101 0.0535 0.0526
Brugia malayi Blistered cuticle protein 3 0.0078 0.0397 0.0912
Trypanosoma brucei glycosyl hydrolase-like protein 0.0027 0.0089 0.0731
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0056 0.0146
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0056 0.0457
Trichomonas vaginalis maltase-glucoamylase, putative 0.0073 0.0365 0.0893
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.0535 0.0489
Brugia malayi beta-lactamase family protein 0.0035 0.0137 0.0271
Toxoplasma gondii isocitrate dehydrogenase 0.0049 0.0222 0.0411
Mycobacterium tuberculosis Conserved protein 0.0035 0.0137 0.0801
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0032 0.0121 0.0182
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0397 0.0912
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.0535 0.1251
Schistosoma mansoni carbonic anhydrase 0.0101 0.0535 0.0526
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0137 0.0335
Loa Loa (eye worm) glutaminase 0.0265 0.1528 0.3665
Schistosoma mansoni hypothetical protein 0.0065 0.0316 0.0307
Echinococcus multilocularis carbonic anhydrase 0.0101 0.0535 0.0489
Echinococcus granulosus carbonic anhydrase 0.0101 0.0535 0.0489
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0369 0.0777
Loa Loa (eye worm) carbonic anhydrase 3 0.0214 0.1222 0.2906
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0318 0.0668
Toxoplasma gondii histone lysine methyltransferase SET1 0.0224 0.128 0.3036
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0365 0.0893
Echinococcus granulosus peroxidasin 0.0078 0.0397 0.0351
Loa Loa (eye worm) histone methyltransferase 0.0039 0.0159 0.0275
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0369 0.0777
Loa Loa (eye worm) hypothetical protein 0.0101 0.0535 0.1205
Loa Loa (eye worm) hypothetical protein 0.0078 0.0397 0.0865
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0012 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0086 0.021
Echinococcus multilocularis peroxidasin 0.0078 0.0397 0.0351
Onchocerca volvulus Peroxidasin homolog 0.0078 0.0397 0.1191
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0137 0.1119
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0316 0.0269
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0073 0.0365 0.0872
Schistosoma mansoni rab6-interacting 0.002 0.0048 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0688 0.4087 1
Brugia malayi Uncoordinated protein 44 0.0032 0.0121 0.0233
Loa Loa (eye worm) hypothetical protein 0.0078 0.0397 0.0865
Loa Loa (eye worm) hypothetical protein 0.0204 0.1159 0.275
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.083 0.4943 0.4918
Onchocerca volvulus Peroxidasin homolog 0.0078 0.0397 0.1191
Echinococcus granulosus mixed lineage leukemia protein mll 0.0031 0.0116 0.0068
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0056 0.002
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0369 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.022
Loa Loa (eye worm) hypothetical protein 0.0078 0.0397 0.0865
Brugia malayi MH2 domain containing protein 0.0117 0.0635 0.1497
Brugia malayi Pre-SET motif family protein 0.0444 0.2613 0.6368
Onchocerca volvulus 0.0035 0.0137 0.0303
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0137 0.022
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0089 0.0218
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.1274 1
Toxoplasma gondii hypothetical protein 0.0101 0.0535 0.1187
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0316 0.1839 0.18
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0187 0.014
Echinococcus multilocularis Niemann Pick C1 protein 0.0144 0.0796 0.0752
Echinococcus multilocularis netrin receptor unc 5 0.0032 0.0121 0.0074
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0101 0.0535 0.125
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0222 0.0175
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0369 0.0843
Schistosoma mansoni carbonic anhydrase-related 0.0101 0.0535 0.0526
Echinococcus granulosus carbonic anhydrase 0.0101 0.0535 0.0489
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0801 0.0757
Echinococcus multilocularis GPCR, family 2 0.0065 0.0316 0.0269
Brugia malayi Doublecortin family protein 0.002 0.0048 0.0051
Toxoplasma gondii Erv1 / Alr family protein 0.0038 0.0154 0.0243
Onchocerca volvulus 0.0022 0.0056 0.0028
Plasmodium vivax acyl-CoA synthetase, putative 0.0055 0.0257 0.0518
Onchocerca volvulus 0.0066 0.0324 0.0943
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0031 0.0116 0.0068
Schistosoma mansoni mixed-lineage leukemia protein mll 0.025 0.144 0.1432
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0222 0.0175
Brugia malayi Muscleblind-like protein 0.0145 0.0801 0.1907
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0137 0.0335
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0121 0.0233
Loa Loa (eye worm) hypothetical protein 0.0078 0.0397 0.0865
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0049 0.0222 0.043
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0086 0.021
Brugia malayi beta-lactamase family protein 0.0035 0.0137 0.0271
Brugia malayi beta-lactamase 0.0035 0.0137 0.0271
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0056 0.002
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0222 0.0175
Loa Loa (eye worm) hypothetical protein 0.0139 0.0769 0.1785
Leishmania major hypothetical protein, conserved 0.0026 0.0082 0.0066
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0239 0.1626
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0086 0.021
Brugia malayi F/Y-rich N-terminus family protein 0.0038 0.0156 0.0318
Loa Loa (eye worm) hypothetical protein 0.0055 0.0257 0.0518
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0397 0.0912
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0056 0.0146
Schistosoma mansoni hypothetical protein 0.1666 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0239 0.1626
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0086 0.021
Loa Loa (eye worm) hypothetical protein 0.0078 0.0397 0.0865
Onchocerca volvulus Netrin receptor homolog 0.0032 0.0121 0.0251
Loa Loa (eye worm) DnaJ domain-containing protein 0.0063 0.0305 0.0636
Schistosoma mansoni peroxidasin 0.0078 0.0397 0.0388
Echinococcus granulosus geminin 0.0164 0.0919 0.0875
Brugia malayi hypothetical protein 0.002 0.0048 0.0051
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0214 0.1222 0.2943
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0365 0.0893
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0086 0.021
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0089 0.0218
Loa Loa (eye worm) hypothetical protein 0.0073 0.0369 0.0795
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0056 0.0072
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0038 0.0154 0.0107
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0316 0.0712
Onchocerca volvulus 0.0022 0.0056 0.0028
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0049 0.0222 0.0175
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0137 0.0089
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0038 0.0154 0.1259
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0049 0.0222 0.1486
Onchocerca volvulus Chorion peroxidase homolog 0.0078 0.0397 0.1191
Leishmania major macrophage migration inhibitory factor-like protein 0.0688 0.4087 1
Brugia malayi hypothetical protein 0.0146 0.0811 0.1932
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0222 0.0411
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0318 0.0309
Loa Loa (eye worm) hypothetical protein 0.0101 0.0535 0.1205
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0038 0.0154 0.1259
Leishmania major glycosyl hydrolase-like protein 0.0027 0.0089 0.0083
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0089 0.0218
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0038 0.0154 0.0263
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0056 0.0137
Loa Loa (eye worm) oxidoreductase 0.0022 0.0056 0.002
Plasmodium vivax SET domain protein, putative 0.0066 0.0324 0.0685
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0039 0.0159 0.0111
Loa Loa (eye worm) hypothetical protein 0.0078 0.0397 0.0865
Loa Loa (eye worm) hypothetical protein 0.0053 0.0246 0.0491
Loa Loa (eye worm) hypothetical protein 0.0101 0.0535 0.1206
Trypanosoma brucei glucosidase, putative 0.0073 0.0365 0.2986
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0137 0.0801
Onchocerca volvulus 0.0022 0.0056 0.0028
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0073 0.0369 0.2679
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0324 0.0315
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0086 0.021
Loa Loa (eye worm) isocitrate dehydrogenase 0.0049 0.0222 0.043
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0032 0.0121 0.0074
Echinococcus granulosus netrin receptor unc 5 0.0032 0.0121 0.0074
Mycobacterium ulcerans lipase LipD 0.0035 0.0137 0.0549
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0038 0.0154 0.0107
Loa Loa (eye worm) hypothetical protein 0.0055 0.0257 0.0518
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.0535 0.1289
Loa Loa (eye worm) hypothetical protein 0.0032 0.0122 0.0184
Echinococcus multilocularis Rac GTPase activating protein 1 0.0075 0.0381 0.0335
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0239 0.1626
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0056 0.0115
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0688 0.4087 1
Schistosoma mansoni ankyrin 23/unc44 0.0032 0.0121 0.0112
Schistosoma mansoni loxhd1 0.002 0.0048 0.0039
Brugia malayi Glycosyl hydrolases family 31 protein 0.0073 0.0365 0.0832
Schistosoma mansoni cpg binding protein 0.0124 0.0673 0.0665
Schistosoma mansoni alpha glucosidase 0.0073 0.0365 0.0356
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0086 0.021
Onchocerca volvulus 0.0146 0.0811 0.2602
Echinococcus multilocularis protein patched 0.0043 0.0187 0.014
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0073 0.0369 0.2127
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0688 0.4087 1
Schistosoma mansoni rab6-interacting 0.002 0.0048 0.0039
Echinococcus multilocularis protein dispatched 1 0.0049 0.0224 0.0177
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0056 0.0137
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0082 0.0674
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0137 0.0128
Echinococcus granulosus expressed conserved protein 0.0095 0.0498 0.0452
Brugia malayi hypothetical protein 0.0078 0.0397 0.0912
Loa Loa (eye worm) hypothetical protein 0.0026 0.0082 0.0086
Onchocerca volvulus Peroxidase homolog 0.0078 0.0397 0.1191
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0073 0.0369 0.2127
Echinococcus granulosus dnaJ subfamily C 6 0.0063 0.0305 0.0258
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.022
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0082 0.0674
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0012 0.0029
Schistosoma mansoni polycystin 1-related 0.002 0.0048 0.0039
Brugia malayi CHE-14 protein 0.0043 0.0187 0.0395
Schistosoma mansoni hypothetical protein 0.0042 0.0178 0.0169
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0688 0.4087 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0324 0.0315
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.022
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0137 0.1119
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0086 0.021
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0635 0.1453
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0286 0.1563
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0086 0.021
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0286 0.0277
Mycobacterium tuberculosis Conserved protein 0.0035 0.0137 0.0801
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0073 0.0369 0.2127
Trichomonas vaginalis set domain proteins, putative 0.0505 0.2982 0.7295
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0324 0.0278
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0137 0.0801
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0369 0.0882
Echinococcus granulosus nuclear factor of activated T cells 5 0.0316 0.1839 0.18
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0086 0.021
Schistosoma mansoni netrin receptor unc5 0.0032 0.0121 0.0112
Echinococcus granulosus carbonic anhydrase II 0.0214 0.1222 0.118
Loa Loa (eye worm) hypothetical protein 0.0078 0.0397 0.0865
Brugia malayi CXXC zinc finger family protein 0.0117 0.0633 0.1493
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0056 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0187 0.0458
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0365 0.2986
Giardia lamblia Macrophage migration inhibitory factor 0.0688 0.4087 1
Loa Loa (eye worm) blistered cuticle protein 3 0.0078 0.0397 0.0865
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0187 0.014
Brugia malayi Augmenter of liver regeneration 0.0038 0.0154 0.0313
Mycobacterium tuberculosis Conserved protein 0.0035 0.0137 0.0801
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0214 0.1222 0.2906
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0056 0.0047
Loa Loa (eye worm) glutaminase 2 0.0265 0.1528 0.3665
Loa Loa (eye worm) hypothetical protein 0.0075 0.0381 0.0824
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0056 0.0457
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0032 0.0122 0.0113
Onchocerca volvulus 0.0505 0.2982 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0324 0.0315
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0316 0.0269
Schistosoma mansoni hypothetical protein 0.0042 0.0178 0.0169
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.0089 0.0731
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0056 0.0146
Onchocerca volvulus 0.0035 0.0137 0.0303
Schistosoma mansoni hypothetical protein 0.0139 0.0769 0.076
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0056 0.0146
Echinococcus multilocularis neutral alpha glucosidase AB 0.0073 0.0365 0.0319
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0101 0.0535 0.125
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0137 0.0801
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0397 0.0912
Plasmodium falciparum macrophage migration inhibitory factor 0.0688 0.4087 1
Echinococcus granulosus Ankyrin 0.0032 0.0122 0.0075
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0089 0.0218
Brugia malayi hypothetical protein 0.0026 0.0082 0.0137
Mycobacterium ulcerans beta-lactamase 0.0035 0.0137 0.0549
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0056 0.0457
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0397 0.0912
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0137 0.0128
Brugia malayi Calcitonin receptor-like protein seb-1 0.0204 0.1159 0.2788
Trichomonas vaginalis glutaminase, putative 0.0265 0.1528 0.3738
Brugia malayi Pre-SET motif family protein 0.0066 0.0324 0.0733
Brugia malayi isocitrate dehydrogenase 0.0049 0.0222 0.048
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0365 0.0893
Echinococcus multilocularis dnaJ subfamily B 0.1666 1 1
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0316 0.0712
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.0089 0.0731
Trichomonas vaginalis helicase, putative 0.0027 0.0086 0.021
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0286 0.0571
Mycobacterium leprae Probable lipase LipE 0.0035 0.0137 0.2583
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0049 0.0222 0.0213
Echinococcus multilocularis carbonic anhydrase 0.0101 0.0535 0.0489
Trypanosoma brucei carbonic anhydrase-like protein 0.0214 0.1222 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0257 0.0518
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0031 0.0116 0.0106
Schistosoma mansoni lipoxygenase 0.0084 0.0436 0.0427
Brugia malayi RNA binding protein 0.0065 0.0318 0.0716
Leishmania major carbonic anhydrase-like protein 0.0214 0.1222 0.2892
Schistosoma mansoni hypothetical protein 0.0063 0.0305 0.0296
Loa Loa (eye worm) hypothetical protein 0.0078 0.0397 0.0865
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0327 0.1905 0.4597
Onchocerca volvulus 0.0078 0.0397 0.1191
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0048 0.0094
Loa Loa (eye worm) hypothetical protein 0.0146 0.0811 0.1891
Loa Loa (eye worm) hypothetical protein 0.0022 0.0056 0.002
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.0535 0.125
Echinococcus granulosus tar DNA binding protein 0.0065 0.0318 0.0271
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.0397 0.0865
Loa Loa (eye worm) hypothetical protein 0.0073 0.0369 0.0795
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0286 0.0277
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0073 0.0365 0.0893
Echinococcus multilocularis lysosomal alpha glucosidase 0.0327 0.1905 0.1866
Onchocerca volvulus 0.0117 0.0633 0.1995
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0365 0.2986
Schistosoma mansoni lipoxygenase 0.0121 0.0655 0.0647
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0444 0.2613 0.6349
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0038 0.0154 0.1259
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0137 0.0801
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0286 0.1563
Onchocerca volvulus Peroxidase homolog 0.0078 0.0397 0.1191
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0049 0.0222 0.1813
Brugia malayi Glycosyl hydrolases family 31 protein 0.0027 0.0089 0.0154
Loa Loa (eye worm) hypothetical protein 0.0073 0.0369 0.0795
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.0324 0.0278
Plasmodium falciparum acyl-CoA synthetase 0.0055 0.0257 0.0608
Echinococcus multilocularis carbonic anhydrase 0.0101 0.0535 0.0489
Echinococcus multilocularis dnaJ subfamily C 6 0.0063 0.0305 0.0258
Brugia malayi RhoGAP domain containing protein 0.0065 0.0318 0.0718
Trichomonas vaginalis hypothetical protein 0.0014 0.0012 0.0029
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0031 0.0116 0.0068
Echinococcus granulosus lysosomal alpha glucosidase 0.0327 0.1905 0.1866
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.0397 0.0865
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0214 0.1222 0.2943
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0086 0.021
Loa Loa (eye worm) hypothetical protein 0.0055 0.0257 0.0518
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0137 0.0549
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0056 0.0146
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0056 0.0008
Onchocerca volvulus 0.0078 0.0397 0.1191
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0214 0.1222 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0239 0.1626
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0369 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0121 0.0655 0.0611
Schistosoma mansoni hypothetical protein 0.0164 0.0919 0.0911
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0286 0.0239
Onchocerca volvulus Dual oxidase homolog 0.0078 0.0397 0.1191
Brugia malayi RhoGAP domain containing protein 0.0075 0.0381 0.0872
Echinococcus multilocularis microtubule associated protein 2 0.1383 0.829 0.8281
Loa Loa (eye worm) hypothetical protein 0.0078 0.0397 0.0865
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0137 0.0801
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0086 0.021
Brugia malayi latrophilin 2 splice variant baaae 0.0139 0.0769 0.1827
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.0397 0.0865
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0365 0.0893
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0055 0.0257 0.1773
Toxoplasma gondii Erv1 / Alr family protein 0.0038 0.0154 0.0243
Brugia malayi hypothetical protein 0.002 0.0048 0.0051
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0056 0.0072
Schistosoma mansoni hypothetical protein 0.0164 0.0919 0.0911
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0082 0.0086
Schistosoma mansoni glutaminase 0.0265 0.1528 0.152
Brugia malayi Isocitrate dehydrogenase 0.0049 0.0222 0.048
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0369 0.0777
Brugia malayi Peroxidasin 0.0078 0.0397 0.0912
Schistosoma mansoni hypothetical protein 0.0065 0.0316 0.0307
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0073 0.0365 0.0785
Schistosoma mansoni unc-13 (munc13) 0.0016 0.0024 0.0015
Onchocerca volvulus 0.0073 0.0369 0.1095
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0056 0.0146
Loa Loa (eye worm) hypothetical protein 0.0078 0.0397 0.0865
Brugia malayi Death domain containing protein 0.0032 0.0121 0.0233
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.022
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0056 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0086 0.021
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0086 0.021
Trichomonas vaginalis protein kinase inhibitor, putative 0.0063 0.0305 0.0746
Onchocerca volvulus 0.0035 0.0137 0.0303
Echinococcus granulosus microtubule associated protein 2 0.1383 0.829 0.8281
Schistosoma mansoni hypothetical protein 0.0032 0.0121 0.0112
Loa Loa (eye worm) hypothetical protein 0.0055 0.0257 0.0518
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0688 0.4087 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0027 0.0089 0.0218
Loa Loa (eye worm) hypothetical protein 0.0065 0.0316 0.0664
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0056 0.0146
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0204 0.1159 0.2788
Loa Loa (eye worm) hypothetical protein 0.0078 0.0397 0.0865
Brugia malayi DnaJ domain containing protein 0.0063 0.0305 0.0684
Toxoplasma gondii isocitrate dehydrogenase 0.0049 0.0222 0.0411
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0056 0.0115
Loa Loa (eye worm) hypothetical protein 0.0078 0.0397 0.0865
Leishmania major hypothetical protein, conserved 0.0038 0.0154 0.0243
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0086 0.021
Loa Loa (eye worm) hypothetical protein 0.0101 0.0535 0.1205
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0137 0.0271
Echinococcus multilocularis Ankyrin 0.0032 0.0122 0.0075
Echinococcus granulosus muscleblind protein 0.0145 0.0801 0.0757
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.0535 0.125
Loa Loa (eye worm) hypothetical protein 0.0027 0.0089 0.0103
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0318 0.0309
Brugia malayi Protein kinase domain containing protein 0.0032 0.0121 0.0233
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0137 0.1119
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0056 0.0146
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0082 0.0066
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0027 0.0089 0.0196
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0038 0.0154 0.0355
Echinococcus multilocularis isocitrate dehydrogenase 0.0049 0.0222 0.0175
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0316 0.0269
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0055 0.0257 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.0056 0.002
Echinococcus granulosus Rac GTPase activating protein 1 0.0075 0.0381 0.0335
Schistosoma mansoni hypothetical protein 0.0065 0.0316 0.0307
Schistosoma mansoni peroxidasin 0.0078 0.0397 0.0388
Loa Loa (eye worm) hepatopoietin HPO2 0.0038 0.0154 0.0263
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0137 0.0801
Schistosoma mansoni hypothetical protein 0.0101 0.0535 0.0526
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0294 0.1701 0.4093
Schistosoma mansoni cpg binding protein 0.0117 0.0633 0.0624
Loa Loa (eye worm) beta-lactamase 0.0035 0.0137 0.022
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0318 0.0668
Onchocerca volvulus 0.0078 0.0397 0.1191
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0086 0.021
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0324 0.0315
Echinococcus multilocularis expressed conserved protein 0.0095 0.0498 0.0452
Echinococcus granulosus cpg binding protein 0.0124 0.0673 0.0629
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0089 0.0218
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0214 0.1222 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0327 0.1905 0.1866
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0222 0.1813
Echinococcus granulosus neutral alpha glucosidase AB 0.0073 0.0365 0.0319
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.0324 0.0278
Leishmania major alpha glucosidase II subunit, putative 0.0073 0.0365 0.0766
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0056 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0086 0.021
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0187 0.014
Mycobacterium ulcerans hypothetical protein 0.0073 0.0369 0.2127
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0214 0.1222 0.1214
Onchocerca volvulus 0.0189 0.107 0.3484
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0187 0.0345
Loa Loa (eye worm) CXXC zinc finger family protein 0.0117 0.0633 0.1449
Schistosoma mansoni hypothetical protein 0.0042 0.0178 0.0169
Leishmania major hypothetical protein, conserved 0.0035 0.0137 0.0201
Leishmania major macrophage migration inhibitory factor-like protein 0.0688 0.4087 1
Mycobacterium ulcerans hypothetical protein 0.0035 0.0137 0.0549
Echinococcus granulosus GPCR family 2 0.0065 0.0316 0.0269
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0082 0.0674
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0137 0.0801
Echinococcus granulosus Niemann Pick C1 protein 0.0144 0.0796 0.0752
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0369 0.0843
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0073 0.0369 0.2127
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.0535 0.0489
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.0544 0.0536
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0082 0.0179
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0369 0.2127
Loa Loa (eye worm) hypothetical protein 0.0043 0.0187 0.0345
Echinococcus multilocularis muscleblind protein 0.0145 0.0801 0.0757
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0055 0.0257 0.1366
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0137 0.0089
Loa Loa (eye worm) hypothetical protein 0.0066 0.0324 0.0685
Mycobacterium ulcerans glutaminase 0.0265 0.1528 1
Brugia malayi glutaminase DH11.1 0.0265 0.1528 0.3697
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0073 0.0365 0.0766
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0137 0.0335
Echinococcus granulosus carbonic anhydrase 0.0101 0.0535 0.0489
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0056 0.0457
Schistosoma mansoni hypothetical protein 0.002 0.0048 0.0039
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0082 0.0179
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0073 0.0365 0.0893
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0027 0.0089 0.0142
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0137 0.0335
Brugia malayi Glycosyl hydrolases family 31 protein 0.0327 0.1905 0.4625
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.0397 0.0865
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0056 0.0146
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0056 0.0072
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0137 0.0335
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0056 0.0146
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0369 0.2679
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0049 0.0222 0.0521
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0056 0.0457
Loa Loa (eye worm) hypothetical protein 0.0078 0.0397 0.0865
Loa Loa (eye worm) hypothetical protein 0.0078 0.0397 0.0865
Toxoplasma gondii ABC1 family protein 0.0035 0.0137 0.0201
Schistosoma mansoni alpha-glucosidase 0.0282 0.1629 0.1621
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0369 0.2127
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0286 0.0239
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0073 0.0365 0.0872
Schistosoma mansoni alpha-glucosidase 0.0282 0.1629 0.1621
Loa Loa (eye worm) hypothetical protein 0.0145 0.0801 0.1866
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0041 0.0032
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0137 0.2583
Brugia malayi Bm-MIF-1, identical 0.0688 0.4087 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0318 0.0309
Loa Loa (eye worm) hypothetical protein 0.0032 0.0121 0.0182
Echinococcus granulosus death domain containing protein 0.0032 0.0121 0.0074
Schistosoma mansoni hypothetical protein 0.0065 0.0316 0.0307
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0365 0.0893
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.0535 0.125
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0318 0.0309
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0089 0.0218
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0056 0.0072
Trichomonas vaginalis sucrase-isomaltase, putative 0.0073 0.0365 0.0893
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0295 0.0248
Plasmodium falciparum carbonic anhydrase 0.0101 0.0535 0.1288
Schistosoma mansoni patched 1 0.0043 0.0187 0.0178

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 570 nM Inhibitory activity against human carbonic anhydrase II. ChEMBL. 14640555
Ki (binding) = 570 nM Inhibitory activity against human carbonic anhydrase II. ChEMBL. 14640555
Ki (binding) > 1000 nM Inhibitory activity against human carbonic anhydrase IX. ChEMBL. 14640555
Ki (binding) > 1000 nM Inhibitory activity against human carbonic anhydrase IX. ChEMBL. 14640555
Ki (binding) = 4.62 uM Inhibitory activity against human carbonic anhydrase I. ChEMBL. 14640555
Ki (binding) = 4.62 uM Inhibitory activity against human carbonic anhydrase I. ChEMBL. 14640555

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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