TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 458.555 | Formula: C26H30N6O2
H donors: 2 H acceptors: 6 LogP: 5.77 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCCCc1n(CCCC)nc(c1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O
InChi: 1S/C26H30N6O2/c1-3-5-11-23-22(24(26(33)34)29-32(23)16-6-4-2)17-18-12-14-19(15-13-18)20-9-7-8-10-21(20)25-27-30-31-28-25/h7-10,12-15H,3-6,11,16-17H2,1-2H3,(H,33,34)(H,27,28,30,31)
InChiKey: CODPUXFYQOUEGG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	C-14 sterol reductase, putative	0.0089	0.1058	0.201
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0165	0.0314
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0741	0.2314
Brugia malayi	RNA binding protein	0.0064	0.0741	0.2314
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0051	0.005
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0165	0.0314
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.068	0.2124
Echinococcus multilocularis	lamin b receptor	0.0089	0.1058	0.1035
Schistosoma mansoni	hypothetical protein	0.0049	0.0546	0.1706
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0051	0.016
Echinococcus granulosus	BRK domain containing protein	0.0011	0.007	0.0085
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0051	0.016
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0051	0.016
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0051	0.016
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0013	0.0089	0.0065
Brugia malayi	MH2 domain containing protein	0.0008	0.0027	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0165	0.0517
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0291	0.3243
Echinococcus multilocularis	GPCR, family 2	0.0049	0.0546	0.0523
Echinococcus multilocularis	BRK domain	0.0011	0.007	0.0045
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0165	0.0517
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0165	0.0314
Schistosoma mansoni	hypothetical protein	0.0011	0.007	0.0219
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.1082	0.3382
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0165	0.0309
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0165	0.0309
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0165	0.0314
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0027	0.0004
Brugia malayi	Pre-SET motif family protein	0.0211	0.2604	0.8134
Brugia malayi	steroid hormone receptor	0.001	0.0051	0.016
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0741	0.2314
Onchocerca volvulus		0.003	0.031	0.0496
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0165	0.0265
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0051	0.016
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.042	0.5262	1
Echinococcus multilocularis	vesicular acetylcholine transporter	0.0243	0.3007	0.299
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.016
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.0243	0.3007	0.5672
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0027	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1266	0.3956
Loa Loa (eye worm)	BRM protein	0.0042	0.0459	0.1432
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0025	0.0077
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0051	0.0027
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0291	0.3243
Echinococcus granulosus	fucosidase alpha L 1 tissue	0.0427	0.5343	1
Echinococcus multilocularis	Chromo domain	0.0011	0.007	0.0046
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0051	0.016
Trichomonas vaginalis	set domain proteins, putative	0.024	0.2974	1
Loa Loa (eye worm)	Smad1	0.0008	0.0027	0.0083
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0051	0.016
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0051	0.005
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0897	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0106	0.1266	0.3956
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0229	0.2827	0.8833
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0008	0.0025	0.0077
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0077	0.0897	1
Toxoplasma gondii	SWI2/SNF2 Brahma-like putative	0.0012	0.0078	0.0865
Brugia malayi	Pre-SET motif family protein	0.003	0.031	0.0968
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0049	0.0546	0.1706
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0291	0.0553
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0165	0.0314
Brugia malayi	nuclear hormone receptor	0.001	0.0051	0.016
Toxoplasma gondii	SWI2/SNF2 Brahma-like putative	0.001	0.0056	0.0619
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.016
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0049	0.0546	0.1706
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0051	0.016
Brugia malayi	Probable ClpP-like protease	0.0077	0.0897	0.2803
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0897	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0051	0.016
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0049	0.0546	0.0523
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0026	0.026	0.2902
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0165	0.0517
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0051	0.016
Trypanosoma cruzi	sterol C-24 reductase, putative	0.0046	0.0514	0.0976
Brugia malayi	MH1 domain containing protein	0.0008	0.0027	0.0083
Plasmodium vivax	DEAD/DEAH helicase, putative	0.001	0.0056	0.0619
Brugia malayi	MH2 domain containing protein	0.0117	0.1409	0.4401
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0027	0.0004
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0897	0.1679
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0165	0.0314
Brugia malayi	Latrophilin receptor protein 2	0.0049	0.0546	0.1706
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0051	0.016
Schistosoma mansoni	hypothetical protein	0.0049	0.0546	0.1706
Echinococcus granulosus	global transcription activator snf2l2	0.0066	0.076	0.1383
Loa Loa (eye worm)	hypothetical protein	0.003	0.031	0.0968
Brugia malayi	Associated with TFs and helicases family protein	0.0011	0.007	0.0219
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0051	0.0027
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0897	0.5
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.068	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0051	0.016
Loa Loa (eye worm)	type III restriction enzyme	0.0008	0.0025	0.0077
Trypanosoma brucei	unspecified product	0.0019	0.0165	0.0314
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0165	0.0314
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0027	0.0002
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.1082	0.1989
Echinococcus granulosus	peptidase Clp S14 family	0.005	0.0562	0.1011
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.068	0.1273
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0091	0.0173
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0154	0.1887	0.5895
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0165	0.0517
Schistosoma mansoni	DNA repair and recombination protein rad54-related	0.0008	0.0025	0.0077
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.1082	0.1989
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0165	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0051	0.0027
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.0897	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0291	0.3243
Echinococcus multilocularis	BRK domain containing protein	0.0011	0.007	0.0045
Schistosoma mansoni	helicase	0.0066	0.076	0.2374
Echinococcus multilocularis	BRK domain containing protein	0.0011	0.007	0.0045
Schistosoma mansoni	hypothetical protein	0.0106	0.1266	0.3956
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0165	0.0517
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0091	0.0173
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0051	0.005
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.068	0.1273
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.068	0.2124
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0051	0.016
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0025	0.0077
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.031	0.3452
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0165	0.0314
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.0897	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0165	0.0314
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.031	0.0968
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0049	0.0546	0.0523
Echinococcus multilocularis	peptidase Clp (S14 family)	0.005	0.0562	0.0539
Onchocerca volvulus	Huntingtin homolog	0.012	0.1448	0.268
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0165	0.0314
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0291	0.3243
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.016
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0049	0.0546	0.0981
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0165	0.0314
Leishmania major	hypothetical protein, conserved	0.042	0.5262	1
Leishmania major	sterol C-24 reductase, putative	0.0046	0.0514	0.0976
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0051	0.016
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0051	0.016
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0291	0.0553
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0165	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0514	0.1605
Loa Loa (eye worm)	alpha-L-fucosidase	0.0258	0.3201	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0165	0.0314
Schistosoma mansoni	DNA repair and recombination protein rad54-related	0.0008	0.0025	0.0077
Brugia malayi	hypothetical protein	0.0019	0.0161	0.0504
Onchocerca volvulus	Huntingtin homolog	0.012	0.1448	0.268
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.005	0.0562	0.4744
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0051	0.005
Echinococcus multilocularis	Smad4	0.0008	0.0027	0.0002
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0165	0.0517
Leishmania major	DNA polymerase eta, putative	0.0019	0.0165	0.0314
Schistosoma mansoni	alpha-l-fucosidase	0.0258	0.3201	1
Trypanosoma cruzi	C-14 sterol reductase, putative	0.0089	0.1058	0.201
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0027	0.0083
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0051	0.016
Brugia malayi	MH1 domain containing protein	0.0008	0.0027	0.0083
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.005	0.0562	0.7716
Echinococcus multilocularis	muscleblind protein 1	0.0146	0.1781	0.1761
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0051	0.016
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0741	0.1346
Brugia malayi	Alpha-L-fucosidase family protein	0.0258	0.3201	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0211	0.2604	0.8134
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0741	0.2314
Trypanosoma brucei	DNA repair and recombination protein RAD54, putative	0.0008	0.0025	0.0047
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0051	0.016
Schistosoma mansoni	hypothetical protein	0.0013	0.0089	0.0279
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0165	0.0314
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0165	0.0314
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.016
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.1082	0.106
Plasmodium vivax	DNA repair protein RAD54, putative	0.0008	0.0025	0.0276
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.005	0.0562	0.7716
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0165	0.0141
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0051	0.016
Toxoplasma gondii	hypothetical protein	0.0026	0.026	0.2902
Echinococcus granulosus	muscleblind protein	0.0146	0.1781	0.3303
Echinococcus multilocularis	fucosidase, alpha L 1, tissue	0.0427	0.5343	0.5331
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1781	0.5565
Brugia malayi	follicle stimulating hormone receptor	0.0229	0.2827	0.8833
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.1409	0.4401
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0025	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1781	0.5565
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.042	0.5262	1
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0113	0.1362	0.4437
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0741	0.2314
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0051	0.005
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0051	0.005
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0027	0.0083
Loa Loa (eye worm)	BRM protein	0.0034	0.0357	0.1116
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0051	0.0027
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0051	0.016
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.068	0.1273
Trypanosoma cruzi	Emopamil binding protein, putative	0.042	0.5262	1
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0165	0.0303
Schistosoma mansoni	vesicular acetylcholine transporter	0.0243	0.3007	0.9394
Trypanosoma brucei	Emopamil binding protein, putative	0.042	0.5262	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0051	0.016
Mycobacterium ulcerans	alpha-L-fucosidase	0.0427	0.5343	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0051	0.016
Trypanosoma cruzi	C-14 sterol reductase, putative	0.0089	0.1058	0.201
Leishmania major	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.042	0.5262	1
Trypanosoma brucei	unspecified product	0.0013	0.0091	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0025	0.0077
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.016
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0051	0.016
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0051	0.016
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0051	0.016
Schistosoma mansoni	hypothetical protein	0.0049	0.0546	0.1706
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0165	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0546	0.1706
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0051	0.016
Trypanosoma cruzi	DNA repair and recombination protein RAD54, putative	0.0008	0.0025	0.0047
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0027	0.0083
Loa Loa (eye worm)	helicase DNA-binding protein	0.0011	0.007	0.0219
Plasmodium falciparum	DNA repair and recombination protein RAD54, putative	0.0008	0.0025	0.0276
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0051	0.016
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0165	0.0265
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0051	0.0027
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0165	0.0141
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.016
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0051	0.0027
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0154	0.1887	0.5895
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0051	0.016
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0165	0.0303
Brugia malayi	Smad1	0.0008	0.0027	0.0083
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0026	0.026	0.2902
Brugia malayi	TAR-binding protein	0.0064	0.0741	0.2314
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0051	0.0027
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0897	0.1679
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.016
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.1082	0.3382
Brugia malayi	hypothetical protein	0.012	0.1448	0.4523
Echinococcus granulosus	Smad4	0.0008	0.0027	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0897	0.2803
Echinococcus multilocularis	chromodomain helicase DNA binding protein 7	0.0011	0.007	0.0045
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.031	0.0968
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.1409	0.4401
Onchocerca volvulus		0.024	0.2974	0.5608
Schistosoma mansoni	Lamin B receptor (ERG24)	0.0089	0.1058	0.3304
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0165	0.0517
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0113	0.1362	0.4437
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0051	0.016
Brugia malayi	vesicular acetylcholine transporter unc-17	0.0243	0.3007	0.9394
Brugia malayi	hypothetical protein	0.0029	0.0291	0.0909
Echinococcus granulosus	Chromo domain	0.0011	0.007	0.0085
Echinococcus granulosus	GPCR family 2	0.0049	0.0546	0.0981
Echinococcus granulosus	lamin b receptor	0.0089	0.1058	0.1942
Trypanosoma brucei	C-14 sterol reductase, putative	0.0089	0.1058	0.201
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.1082	0.106
Echinococcus multilocularis	smad	0.0008	0.0027	0.0002
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0051	0.016
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0051	0.005
Trypanosoma cruzi	Emopamil binding protein, putative	0.042	0.5262	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0051	0.0027
Plasmodium vivax	SET domain protein, putative	0.003	0.031	0.3452
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.068	0.0657
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0051	0.016
Echinococcus multilocularis	muscleblind protein	0.0146	0.1781	0.1761
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0051	0.016
Echinococcus multilocularis	BRK domain containing protein	0.0011	0.007	0.0045
Plasmodium falciparum	DEAD/DEAH box helicase, putative	0.001	0.0056	0.0619
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0741	0.2314
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0165	0.0314
Schistosoma mansoni	hypothetical protein	0.0011	0.007	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1887	0.5895
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0165	0.0314
Schistosoma mansoni	Smad4	0.0008	0.0027	0.0083
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0897	0.5
Trypanosoma cruzi	sterol C-24 reductase, putative	0.0046	0.0514	0.0976
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0051	0.0027
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0165	0.0314
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.031	0.0536
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0741	0.0718
Leishmania major	DNA repair and recombination protein RAD54, putative	0.0008	0.0025	0.0047
Loa Loa (eye worm)	hypothetical protein	0.012	0.1448	0.4523
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0051	0.016
Echinococcus granulosus	vesicular acetylcholine transporter	0.0243	0.3007	0.5608
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.031	0.0968
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0165	0.0141
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0296	0.0509
Brugia malayi	recombination factor GdRad54	0.0008	0.0025	0.0077
Brugia malayi	Muscleblind-like protein	0.0146	0.1781	0.5565
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0051	0.005
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.031	0.0286
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0051	0.016
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.068	0.1292
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0077	0.0897	0.1641
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.1082	0.3382
Trypanosoma cruzi	DNA repair and recombination protein RAD54, putative	0.0008	0.0025	0.0047
Brugia malayi	ecdysteroid receptor	0.001	0.0051	0.016
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.0243	0.3007	0.9394
Echinococcus granulosus	dna polymerase eta	0.0019	0.0165	0.0265
Trypanosoma brucei	unspecified product	0.0013	0.0091	0.0173
Onchocerca volvulus		0.042	0.5262	1
Echinococcus multilocularis	BRK domain containing protein	0.0011	0.007	0.0045
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0165	0.0314
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0091	0.1082	0.3382
Echinococcus multilocularis	BRK domain containing protein	0.0011	0.007	0.0045
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0027	0.0002
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.068	0.1232
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0077	0.0897	0.0875
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0741	0.2314
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0291	0.0553
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0051	0.005
Loa Loa (eye worm)	hypothetical protein	0.012	0.1448	0.4523
Brugia malayi	nuclear receptor NHR-88	0.001	0.0051	0.016
Leishmania major	hypothetical protein, conserved	0.0029	0.0291	0.0553
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.031	0.0286
Echinococcus multilocularis	global transcription activator snf2l2	0.0066	0.076	0.0737
Echinococcus multilocularis	BRK domain containing protein	0.0011	0.007	0.0045
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0091	0.1082	0.3382
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0897	0.5
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0154	0.1887	0.5895
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0165	0.0314
Schistosoma mansoni	smad	0.0008	0.0027	0.0083
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.068	0.7579
Schistosoma mansoni	hypothetical protein	0.0049	0.0546	0.1706
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0051	0.016
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0741	0.2314
Brugia malayi	BRM protein	0.0066	0.076	0.2374
Schistosoma mansoni	peptidase Clp (S14 family)	0.0077	0.0897	0.2803
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0027	0.0083
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0741	0.2314
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0051	0.016
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0741	0.2314
Brugia malayi	MH2 domain containing protein	0.0008	0.0027	0.0083
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0091	0.0173
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0049	0.0546	0.0981
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0077	0.0897	1
Echinococcus granulosus	smad	0.0008	0.0027	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0291	0.0909
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.031	0.0968
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0013	0.0089	0.0122
Loa Loa (eye worm)	hypothetical protein	0.001	0.0051	0.016
Schistosoma mansoni	coup transcription factor	0.001	0.0051	0.016
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0165	0.0314
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0027	0.0083

Activities

Activity type	Activity value	Assay description	Source	Reference
pKB (binding)	= 8	In vitro inhibition of ATII induced contractions of the isolated rabbit aorta.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 25999