Detailed information for compound 262883

Basic information

Technical information
  • TDR Targets ID: 262883
  • Name: toxin NT-1
  • MW: 382.405 | Formula: C19H26O8
  • H donors: 2 H acceptors: 4 LogP: -0.91 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@]12C[C@H](OC(=O)C)C(=C[C@H]1O[C@H]1[C@@]3([C@]2(C)[C@H](OC(=O)C)[C@H]1O)OC3)C
  • InChi: 1S/C19H26O8/c1-9-5-13-18(7-20,6-12(9)25-10(2)21)17(4)15(26-11(3)22)14(23)16(27-13)19(17)8-24-19/h5,12-16,20,23H,6-8H2,1-4H3/t12-,13+,14+,15+,16+,17+,18+,19-/m0/s1
  • InChiKey: UROCTWOJYLMRHO-WVJYZQHISA-N  


Substructure search Similarity search

Network

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Synonyms

  • 65180-29-2
  • Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 4,8-diacetate, (3alpha,4beta,8alpha)-
  • 4beta,8alpha-Diacetoxy-12,13-epoxytrichothec-9-ene-3alpha,15-diol
  • Toxin NT 1

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0654 0.1755
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0073 0.0195
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0923 0.0923
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0063 0.052 0.1396
Loa Loa (eye worm) hypothetical protein 0.0124 0.1201 0.3222
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.062 0.8481
Schistosoma mansoni septate junction protein 0.0114 0.1084 0.2908
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0072 0.062 1
Schistosoma mansoni hypothetical protein 0.0074 0.0648 0.1739
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0073 0.0195
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.062 0.1663
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0073 0.0195
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.062 0.8481
Loa Loa (eye worm) animal heme peroxidase 0.0351 0.3727 1
Giardia lamblia High cysteine protein 0.0114 0.1084 0.5
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0691 0.1854
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0073 0.0195
Brugia malayi hypothetical protein 0.0028 0.0139 0.0372
Onchocerca volvulus 0.0351 0.3727 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0222 0.0596
Brugia malayi Animal haem peroxidase family protein 0.0351 0.3727 1
Loa Loa (eye worm) TAR-binding protein 0.0075 0.0654 0.1755
Brugia malayi hypothetical protein 0.0018 0.0026 0.0071
Echinococcus multilocularis GPCR, family 2 0.0034 0.0205 0.0205
Brugia malayi beta-lactamase family protein 0.0036 0.0222 0.0596
Echinococcus multilocularis fat cadherin tumor suppressor 0.0114 0.1084 0.1084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0073 0.0195
Loa Loa (eye worm) hypothetical protein 0.0351 0.3727 1
Brugia malayi notch-like transmembrane receptor 0.0114 0.1084 0.2908
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0073 0.0195
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1166 0.3127
Onchocerca volvulus 0.0031 0.0169 0.0264
Loa Loa (eye worm) hypothetical protein 0.0351 0.3727 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0073 0.0195
Brugia malayi EGF-like domain containing protein 0.0114 0.1084 0.2908
Schistosoma mansoni lamin 0.0031 0.0169 0.0453
Brugia malayi Delta serrate ligand family protein 0.0114 0.1084 0.2908
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0205 0.0205
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0238 0.2195
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0923 0.2475
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0073 0.0195
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.02 0.0536
Onchocerca volvulus 0.0114 0.1084 0.2767
Onchocerca volvulus 0.028 0.2933 0.7828
Onchocerca volvulus Neurogenic locus notch homolog 0.0114 0.1084 0.2767
Echinococcus multilocularis notch 0.0114 0.1084 0.1084
Loa Loa (eye worm) hypothetical protein 0.0023 0.0073 0.0195
Loa Loa (eye worm) hypothetical protein 0.0114 0.1084 0.2908
Echinococcus granulosus protein jagged 1 0.0114 0.1084 0.2908
Loa Loa (eye worm) hypothetical protein 0.0023 0.0073 0.0195
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0073 0.0195
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0073 0.0195
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0122 0.1759
Brugia malayi beta-lactamase family protein 0.0036 0.0222 0.0596
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0222 0.0934
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0073 0.0195
Brugia malayi Cadherin domain containing protein 0.0114 0.1084 0.2908
Onchocerca volvulus 0.0036 0.0222 0.0409
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0073 0.0073
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0392 0.1647
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0214 0.0575
Schistosoma mansoni hypothetical protein 0.0336 0.3551 0.9526
Brugia malayi Peroxidasin 0.0351 0.3727 1
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0222 0.0934
Echinococcus granulosus polycomb protein SCMH1 0.0055 0.0436 0.1169
Schistosoma mansoni hypothetical protein 0.0167 0.1673 0.4489
Brugia malayi RNA binding protein 0.0075 0.0654 0.1755
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0222 0.9341
Loa Loa (eye worm) hypothetical protein 0.0023 0.0073 0.0195
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0691 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0222 0.0596
Loa Loa (eye worm) hypothetical protein 0.0063 0.052 0.1396
Loa Loa (eye worm) hypothetical protein 0.0114 0.1084 0.2908
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0073 0.0195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0073 0.0195
Echinococcus granulosus geminin 0.0167 0.1673 0.4489
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0691 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0392 0.0392
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0073 0.0073
Echinococcus multilocularis histone acetyltransferase MYST2 0.0063 0.052 0.052
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0691 1
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0436 0.1169
Schistosoma mansoni hypothetical protein 0.0114 0.1084 0.2908
Mycobacterium tuberculosis Conserved protein 0.0036 0.0222 0.0934
Onchocerca volvulus Dual oxidase homolog 0.0351 0.3727 1
Echinococcus multilocularis muscleblind protein 1 0.0175 0.1762 0.1762
Loa Loa (eye worm) hypothetical protein 0.0351 0.3727 1
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0073 0.0195
Brugia malayi intermediate filament protein 0.0031 0.0169 0.0453
Onchocerca volvulus Peroxidase homolog 0.0351 0.3727 1
Schistosoma mansoni coup transcription factor 0.0023 0.0073 0.0195
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0238 0.0058
Schistosoma mansoni laminin gamma-3 chain 0.0114 0.1084 0.2908
Onchocerca volvulus 0.0351 0.3727 1
Brugia malayi ecdysteroid receptor 0.0023 0.0073 0.0195
Loa Loa (eye worm) hypothetical protein 0.0078 0.0691 0.1854
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0238 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0194 0.0817
Echinococcus multilocularis neurogenic locus protein delta 0.0114 0.1084 0.1084
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0218 0.2239 0.2239
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0691 0.6375
Loa Loa (eye worm) MBCTL1 0.0063 0.052 0.1396
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0691 0.6375
Echinococcus multilocularis neurogenic locus protein delta 0.0114 0.1084 0.1084
Echinococcus granulosus lamin dm0 0.0031 0.0169 0.0453
Loa Loa (eye worm) hypothetical protein 0.0114 0.1084 0.2908
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0114 0.1084 0.2908
Schistosoma mansoni notch 0.0114 0.1084 0.2908
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0648 0.1739
Schistosoma mansoni lamin 0.0031 0.0169 0.0453
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0214 0.1977
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0238 0.0334
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0073 0.0195
Loa Loa (eye worm) hypothetical protein 0.0114 0.1084 0.2908
Loa Loa (eye worm) hypothetical protein 0.0036 0.0222 0.0596
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0392 0.1647
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0139 0.5827
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0114 0.1084 0.2767
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0073 0.0195
Echinococcus granulosus intermediate filament protein 0.0031 0.0169 0.0453
Loa Loa (eye worm) hypothetical protein 0.0351 0.3727 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0222 0.0596
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0169 0.0453
Echinococcus multilocularis protein jagged 1 0.0114 0.1084 0.1084
Mycobacterium tuberculosis Conserved protein 0.0036 0.0222 0.0934
Loa Loa (eye worm) animal heme peroxidase 0.0351 0.3727 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0205 0.0549
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0222 0.0934
Loa Loa (eye worm) hypothetical protein 0.0031 0.0169 0.0453
Loa Loa (eye worm) hypothetical protein 0.0114 0.1084 0.2908
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0055 0.0436 0.0993
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0691 0.5
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0073 0.0195
Schistosoma mansoni peroxidasin 0.0351 0.3727 1
Brugia malayi Inositol-1 0.0037 0.0238 0.0638
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0073 0.0195
Echinococcus granulosus SAM and MBT domain containing protein 0.0055 0.0436 0.1169
Loa Loa (eye worm) hypothetical protein 0.0114 0.1084 0.2908
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0073 0.0195
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0238 0.3838
Brugia malayi Animal haem peroxidase family protein 0.0351 0.3727 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0114 0.1084 0.2908
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0691 0.1854
Brugia malayi Animal haem peroxidase family protein 0.0351 0.3727 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.062 0.8481
Loa Loa (eye worm) inositol-1 0.0037 0.0238 0.0638
Mycobacterium tuberculosis Conserved protein 0.0036 0.0222 0.0934
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0222 0.0934
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.0923 0.2475
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0205 0.0549
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.0114 0.1084 0.2908
Onchocerca volvulus 0.0114 0.1084 0.2767
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0063 0.052 0.052
Echinococcus granulosus tar DNA binding protein 0.0075 0.0654 0.1755
Loa Loa (eye worm) hypothetical protein 0.0351 0.3727 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0214 0.0214
Schistosoma mansoni hypothetical protein 0.0114 0.1084 0.2908
Loa Loa (eye worm) hypothetical protein 0.0023 0.0073 0.0195
Onchocerca volvulus Huntingtin homolog 0.0124 0.1201 0.3087
Echinococcus multilocularis neural cadherin 0.0114 0.1084 0.1084
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0072 0.062 0.2607
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0073 0.0195
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0073 0.0195
Loa Loa (eye worm) hypothetical protein 0.0023 0.0073 0.0195
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.2377 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0222 0.0596
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0205 0.0549
Brugia malayi EGF-like domain containing protein 0.0114 0.1084 0.2908
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0169 0.0453
Onchocerca volvulus 0.0055 0.0436 0.0993
Loa Loa (eye worm) hypothetical protein 0.0074 0.0648 0.1739
Echinococcus multilocularis SAM and MBT domain containing protein 0.0055 0.0436 0.0436
Loa Loa (eye worm) Notch2 0.0114 0.1084 0.2908
Schistosoma mansoni slit 0.0114 0.1084 0.2908
Toxoplasma gondii aldehyde dehydrogenase 0.0072 0.062 0.5718
Loa Loa (eye worm) hypothetical protein 0.0036 0.0222 0.0596
Onchocerca volvulus 0.0035 0.0214 0.0388
Schistosoma mansoni notch 0.0114 0.1084 0.2908
Echinococcus multilocularis polycomb protein SCMH1 0.0055 0.0436 0.0436
Echinococcus multilocularis protein jagged 1 0.0114 0.1084 0.1084
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0222 0.9341
Leishmania major hypothetical protein, conserved 0.0036 0.0222 0.3585
Echinococcus granulosus notch 0.0114 0.1084 0.2908
Loa Loa (eye worm) hypothetical protein 0.0114 0.1084 0.2908
Brugia malayi EGF-like domain containing protein 0.0114 0.1084 0.2908
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.1031 0.2765
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0073 0.0073
Echinococcus multilocularis neurogenic locus notch protein 4 0.0114 0.1084 0.1084
Echinococcus granulosus slit 2 protein 0.0114 0.1084 0.2908
Loa Loa (eye worm) hypothetical protein 0.0023 0.0073 0.0195
Loa Loa (eye worm) hypothetical protein 0.0351 0.3727 1
Loa Loa (eye worm) hypothetical protein 0.0351 0.3727 1
Onchocerca volvulus 0.0114 0.1084 0.2767
Loa Loa (eye worm) hypothetical protein 0.0351 0.3727 1
Brugia malayi Calcium binding EGF domain containing protein 0.0114 0.1084 0.2908
Brugia malayi beta-lactamase 0.0036 0.0222 0.0596
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0073 0.0195
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0392 0.1051
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0073 0.0195
Loa Loa (eye worm) hypothetical protein 0.0175 0.1762 0.4727
Loa Loa (eye worm) blistered cuticle protein 3 0.0351 0.3727 1
Brugia malayi mbt repeat family protein 0.0055 0.0436 0.1169
Toxoplasma gondii EGF family domain-containing protein 0.0114 0.1084 1
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0238 0.0638
Loa Loa (eye worm) hypothetical protein 0.0114 0.1084 0.2908
Onchocerca volvulus Putative cubilin 0.0114 0.1084 0.2767
Loa Loa (eye worm) animal heme peroxidase 0.0351 0.3727 1
Brugia malayi EGF-like domain containing protein 0.0114 0.1084 0.2908
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0923 0.2475
Loa Loa (eye worm) notch protein 0.0114 0.1084 0.2908
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0073 0.0073
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0222 0.0596
Echinococcus multilocularis muscleblind protein 0.0175 0.1762 0.1762
Loa Loa (eye worm) hypothetical protein 0.0028 0.0139 0.0372
Loa Loa (eye worm) hypothetical protein 0.0109 0.1031 0.2765
Echinococcus multilocularis lamin dm0 0.0031 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.0436
Onchocerca volvulus Peroxidasin homolog 0.0351 0.3727 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0073 0.0195
Schistosoma mansoni hypothetical protein 0.0114 0.1084 0.2908
Brugia malayi EGF-like domain containing protein 0.0114 0.1084 0.2908
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0222 0.0934
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0139 0.2006
Echinococcus multilocularis neurogenic locus notch protein 0.0114 0.1084 0.1084
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0073 0.0195
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0205 0.0205
Echinococcus granulosus neurogenic locus notch protein 0.0114 0.1084 0.2908
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0923 0.0923
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0073 0.0195
Brugia malayi Pre-SET motif family protein 0.0246 0.2556 0.6857
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0139 0.1279
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0073 0.0195
Echinococcus multilocularis tar DNA binding protein 0.0075 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0351 0.3727 1
Brugia malayi Animal haem peroxidase family protein 0.0351 0.3727 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0923 0.2475
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0073 0.0195
Schistosoma mansoni notch 0.0114 0.1084 0.2908
Toxoplasma gondii hypothetical protein 0.0027 0.0122 0.1121
Echinococcus granulosus delta-like protein 1 0.0114 0.1084 0.2908
Brugia malayi Pre-SET motif family protein 0.0035 0.0214 0.0575
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0691 0.0691
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0073 0.0073
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0073 0.0073
Brugia malayi TAR-binding protein 0.0075 0.0654 0.1755
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0222 0.0934
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0238 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0139 0.2006
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0073 0.0195
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0073 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0073 0.0195
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0923 0.2475
Loa Loa (eye worm) animal heme peroxidase 0.0351 0.3727 1
Echinococcus multilocularis protein jagged 2 0.0114 0.1084 0.1084
Brugia malayi hypothetical protein 0.0351 0.3727 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0923 0.2475
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0073 0.0195
Schistosoma mansoni hypothetical protein 0.0114 0.1084 0.2908
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0073 0.0195
Loa Loa (eye worm) hypothetical protein 0.0036 0.0222 0.0596
Echinococcus granulosus protein jagged 1 0.0114 0.1084 0.2908
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0075 0.0654 0.1755
Loa Loa (eye worm) RNA binding protein 0.0075 0.0654 0.1755
Leishmania major hypothetical protein, conserved 0.0028 0.0139 0.2236
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.062 0.1663
Brugia malayi GCC2 and GCC3 family protein 0.0114 0.1084 0.2908
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0654 0.1755
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0222 0.3216
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0114 0.1084 0.2908
Loa Loa (eye worm) hypothetical protein 0.0351 0.3727 1
Schistosoma mansoni intermediate filament proteins 0.0031 0.0169 0.0453
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0654 0.1755
Schistosoma mansoni notch 0.0114 0.1084 0.2908
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0073 0.0073
Echinococcus multilocularis slit 2 protein 0.0114 0.1084 0.1084
Brugia malayi nuclear hormone receptor 0.0023 0.0073 0.0195
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1166 0.3127
Brugia malayi RNA recognition motif domain containing protein 0.0075 0.0654 0.1755
Loa Loa (eye worm) hypothetical protein 0.0351 0.3727 1
Echinococcus granulosus neurogenic locus notch protein 0.0114 0.1084 0.2908
Echinococcus granulosus protein jagged 2 0.0114 0.1084 0.2908
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0139 0.5827
Echinococcus granulosus neurogenic locus protein delta 0.0114 0.1084 0.2908
Brugia malayi Probable ClpP-like protease 0.0078 0.0691 0.1854
Onchocerca volvulus Huntingtin homolog 0.0124 0.1201 0.3087
Onchocerca volvulus 0.0114 0.1084 0.2767
Echinococcus multilocularis fibropellin Ia 0.0114 0.1084 0.1084
Brugia malayi Animal haem peroxidase family protein 0.0351 0.3727 1
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0654 0.1755
Trichomonas vaginalis set domain proteins, putative 0.028 0.2933 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0073 0.0195
Loa Loa (eye worm) hypothetical protein 0.0114 0.1084 0.2908
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0691 1
Brugia malayi EGF-like domain containing protein 0.0114 0.1084 0.2908
Loa Loa (eye worm) hypothetical protein 0.0114 0.1084 0.2908
Loa Loa (eye worm) hypothetical protein 0.0023 0.0073 0.0195
Brugia malayi Cadherin domain containing protein 0.0114 0.1084 0.2908
Loa Loa (eye worm) hypothetical protein 0.0351 0.3727 1
Echinococcus granulosus protein jagged 2 0.0114 0.1084 0.2908
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0008 0.0021
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0036 0.0222 0.0596
Loa Loa (eye worm) hypothetical protein 0.0023 0.0073 0.0195
Schistosoma mansoni notch 0.0114 0.1084 0.2908
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.0923 0.2475
Schistosoma mansoni hypothetical protein 0.0167 0.1673 0.4489
Loa Loa (eye worm) hypothetical protein 0.0114 0.1084 0.2908
Echinococcus multilocularis musashi 0.0031 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0175 0.1762 0.4727
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0139 0.2006
Brugia malayi nuclear receptor NHR-88 0.0023 0.0073 0.0195
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0392 0.4744
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0073 0.0073
Brugia malayi Muscle positioning protein 4 0.0114 0.1084 0.2908
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0073 0.0195
Loa Loa (eye worm) hypothetical protein 0.0114 0.1084 0.2908
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0073 0.0195
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0124 0.1201 0.3222
Loa Loa (eye worm) hypothetical protein 0.0034 0.0205 0.0549
Loa Loa (eye worm) hypothetical protein 0.0351 0.3727 1
Schistosoma mansoni hypothetical protein 0.0114 0.1084 0.2908
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0055 0.0436 0.1169
Onchocerca volvulus 0.0114 0.1084 0.2767
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0214 0.0575
Schistosoma mansoni hypothetical protein 0.0034 0.0205 0.0549
Loa Loa (eye worm) hypothetical protein 0.0036 0.0222 0.0596
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0238 0.0058
Loa Loa (eye worm) hypothetical protein 0.0114 0.1084 0.2908
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0205 0.0549
Echinococcus granulosus GPCR family 2 0.0034 0.0205 0.0549
Onchocerca volvulus 0.0351 0.3727 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0073 0.0195
Schistosoma mansoni peroxidasin 0.0351 0.3727 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0238 1
Schistosoma mansoni hypothetical protein 0.0034 0.0205 0.0549
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0073 0.0195
Echinococcus multilocularis lamin 0.0031 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0035 0.0214 0.0575
Plasmodium vivax SET domain protein, putative 0.0035 0.0214 0.3102
Schistosoma mansoni myelin transcription factor 1 myt1 0.0063 0.052 0.1396
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0214 0.0575
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0073 0.0195
Echinococcus granulosus neural cadherin 0.0114 0.1084 0.2908
Loa Loa (eye worm) hypothetical protein 0.0055 0.0436 0.1169
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0072 0.062 0.062
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0073 0.0195
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0691 0.5
Echinococcus granulosus fibropellin Ia 0.0114 0.1084 0.2908
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0073 0.0195
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0205 0.0549
Echinococcus granulosus histone acetyltransferase MYST2 0.0063 0.052 0.1396
Schistosoma mansoni cell polarity protein 0.0114 0.1084 0.2908
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.1031 0.2765
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0073 0.0195
Brugia malayi Muscleblind-like protein 0.0175 0.1762 0.4727
Onchocerca volvulus Peroxidasin homolog 0.0351 0.3727 1
Echinococcus granulosus muscleblind protein 0.0175 0.1762 0.4727
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0063 0.052 0.1396
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0073 0.0195
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0222 0.0934
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0654 0.1755
Echinococcus granulosus peroxidasin 0.0351 0.3727 1
Schistosoma mansoni hypothetical protein 0.0034 0.0205 0.0549
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0073 0.0195
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0222 0.1768
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0238 0.0058
Echinococcus granulosus neurogenic locus notch protein 4 0.0114 0.1084 0.2908
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0139 0.5827
Schistosoma mansoni notch 0.0114 0.1084 0.2908
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0222 0.0222
Toxoplasma gondii ABC1 family protein 0.0036 0.0222 0.205
Loa Loa (eye worm) hypothetical protein 0.0114 0.1084 0.2908
Echinococcus multilocularis peroxidasin 0.0351 0.3727 0.3727
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0238 0.5
Onchocerca volvulus Slit protein homolog 0.0114 0.1084 0.2767
Onchocerca volvulus 0.0036 0.0222 0.0409
Schistosoma mansoni inositol monophosphatase 0.0037 0.0238 0.0638
Onchocerca volvulus Chorion peroxidase homolog 0.0351 0.3727 1
Echinococcus granulosus lamin 0.0031 0.0169 0.0453
Echinococcus multilocularis neurogenic locus notch protein 0.0114 0.1084 0.1084
Brugia malayi mbt repeat family protein 0.0055 0.0436 0.1169
Loa Loa (eye worm) hypothetical protein 0.0114 0.1084 0.2908
Loa Loa (eye worm) beta-lactamase 0.0036 0.0222 0.0596
Schistosoma mansoni hypothetical protein 0.0114 0.1084 0.2908
Onchocerca volvulus 0.0036 0.0222 0.0409
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0246 0.2556 0.6857
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0122 0.1759
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0691 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.1084 0.2908
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0222 0.9341
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0169 0.0453
Loa Loa (eye worm) hypothetical protein 0.0114 0.1084 0.2908
Loa Loa (eye worm) mbt repeat family protein 0.0055 0.0436 0.1169
Brugia malayi Calcium binding EGF domain containing protein 0.0114 0.1084 0.2908
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.1031 0.2765
Brugia malayi Blistered cuticle protein 3 0.0351 0.3727 1
Loa Loa (eye worm) hypothetical protein 0.0351 0.3727 1
Schistosoma mansoni hypothetical protein 0.0034 0.0205 0.0549
Onchocerca volvulus Peroxidase homolog 0.0351 0.3727 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.0238 0.0638
Loa Loa (eye worm) hypothetical protein 0.0114 0.1084 0.2908
Schistosoma mansoni hypothetical protein 0.0114 0.1084 0.2908
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0436 0.1169
Brugia malayi MH2 domain containing protein 0.0121 0.1166 0.3127
Brugia malayi steroid hormone receptor 0.0023 0.0073 0.0195
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0072 0.062 0.1663
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0194 0.1278
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0214 0.0575
Loa Loa (eye worm) hypothetical protein 0.0114 0.1084 0.2908
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0691 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0691 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.1084 0.2908
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0073 0.0195
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0214 0.0575
Onchocerca volvulus 0.0031 0.0169 0.0264
Brugia malayi Calcium binding EGF domain containing protein 0.0114 0.1084 0.2908
Brugia malayi EGF-like domain containing protein 0.0114 0.1084 0.2908
Mycobacterium leprae Probable lipase LipE 0.0036 0.0222 0.1768
Echinococcus multilocularis geminin 0.0167 0.1673 0.1673
Brugia malayi hypothetical protein 0.0124 0.1201 0.3222
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0218 0.2239 0.6008
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0222 0.0596

Activities

Activity type Activity value Assay description Source Reference
LC50 (ADMET) = 60 ng ml-1 Cytotoxicity, assayed on L5178Y mouse lymphoma cells ChEMBL. 2918501
LC50 (ADMET) = 60 ng ml-1 Cytotoxicity, assayed on L5178Y mouse lymphoma cells ChEMBL. 2918501

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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