Detailed information for compound 271957

Basic information

Technical information
  • TDR Targets ID: 271957
  • Name: 1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl ]-1,3-diazepan-2-one
  • MW: 246.26 | Formula: C10H18N2O5
  • H donors: 4 H acceptors: 4 LogP: -1.47 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(C(C1O)O)N1CCCCNC1=O
  • InChi: 1S/C10H18N2O5/c13-5-6-7(14)8(15)9(17-6)12-4-2-1-3-11-10(12)16/h6-9,13-15H,1-5H2,(H,11,16)
  • InChiKey: XFBDBFJTEFLACS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,3-diazepan-2-one
  • 1-[3,4-dihydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-1,3-diazepan-2-one
  • 1-(3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl)-1,3-diazepan-2-one
  • 74024-66-1
  • NSC322095

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0082 0.0152 0.0174
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0722 0.2057 0.2268
Loa Loa (eye worm) hypothetical protein 0.0043 0.0035 0.0039
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0708 0.2012 0.2218
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0047 0.005
Schistosoma mansoni hypothetical protein 0.0041 0.0028 0.0031
Toxoplasma gondii peptidase c13 family protein 0.0708 0.2012 0.5069
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0028 0.0066
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0043 0.0035 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.027 0.071 0.0764
Trichomonas vaginalis inositol monophosphatase, putative 0.0082 0.0152 0.0141
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2849 0.8385 1
Echinococcus granulosus cathepsin b 0.0409 0.1122 0.2644
Trypanosoma cruzi cysteine peptidase, putative 0.0722 0.2057 0.2448
Toxoplasma gondii ABC1 family protein 0.004 0.0026 0.0051
Loa Loa (eye worm) hypothetical protein 0.004 0.0026 0.0029
Echinococcus multilocularis inositol monophosphatase 1 0.0082 0.0152 0.0357
Loa Loa (eye worm) beta-lactamase 0.004 0.0026 0.0029
Schistosoma mansoni DNA polymerase eta 0.0041 0.0028 0.0031
Loa Loa (eye worm) papain family cysteine protease containing protein 0.027 0.071 0.079
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.027 0.071 0.1779
Brugia malayi jmjC domain containing protein 0.0059 0.0082 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.027 0.071 0.0764
Brugia malayi Thioredoxin reductase 0.0085 0.016 0.0178
Trypanosoma cruzi cytidine deaminase-like protein, putative 0.013 0.0292 0.0342
Loa Loa (eye worm) hypothetical protein 0.0052 0.0061 0.0068
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.027 0.071 0.1779
Leishmania major mitochondrial DNA polymerase beta 0.0336 0.0906 0.1063
Trichomonas vaginalis conserved hypothetical protein 0.027 0.071 0.0764
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0082 0.0091
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.027 0.071 0.1779
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0185 0.0456 0.1075
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0082 0.0192
Plasmodium vivax sentrin-specific protease 1, putative 0.0043 0.0035 0.0076
Entamoeba histolytica cysteine protease, putative 0.027 0.071 0.1731
Trichomonas vaginalis set domain proteins, putative 0.0263 0.069 0.0742
Toxoplasma gondii hypothetical protein 0.0054 0.0068 0.0158
Echinococcus multilocularis cytidine deaminase 0.013 0.0292 0.0688
Echinococcus granulosus sentrin specific protease 8 0.0103 0.0213 0.0502
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0028 0.0027
Loa Loa (eye worm) hypothetical protein 0.0148 0.0347 0.0386
Toxoplasma gondii cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein 0.013 0.0292 0.0725
Echinococcus multilocularis sentrin specific protease 8 0.0103 0.0213 0.0502
Giardia lamblia Cysteine protease 0.027 0.071 0.2535
Echinococcus multilocularis caspase 0.0148 0.0347 0.0817
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.027 0.071 0.079
Loa Loa (eye worm) hypothetical protein 0.0042 0.0032 0.0036
Plasmodium vivax metacaspase 1, putative 0.0148 0.0347 0.0863
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.0107 0.0109
Schistosoma mansoni cathepsin F (C01 family) 0.1364 0.3965 0.4414
Onchocerca volvulus 0.0263 0.069 0.0763
Entamoeba histolytica cysteine protease, putative 0.0722 0.2057 0.5153
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0944 0.2716 0.3004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0028 0.0027
Plasmodium falciparum serine repeat antigen 9 0.027 0.071 0.1756
Onchocerca volvulus 0.1364 0.3965 0.4411
Loa Loa (eye worm) hypothetical protein 0.027 0.071 0.079
Brugia malayi Cathepsin L-like precursor 0.1364 0.3965 0.4414
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.021 0.0495
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0103 0.0213 0.0209
Plasmodium falciparum thioredoxin reductase 0.0085 0.016 0.0364
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0708 0.2012 0.2218
Giardia lamblia Cytidine deaminase 0.013 0.0292 0.0982
Echinococcus granulosus tissue type plasminogen activator 0.0037 0.0016 0.0038
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0043 0.0035 0.0036
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0047 0.005
Loa Loa (eye worm) hypothetical protein 0.027 0.071 0.079
Entamoeba histolytica cysteine protease, putative 0.0722 0.2057 0.5153
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0026 0.0024
Loa Loa (eye worm) twinkle helicase 0.011 0.0235 0.0262
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0028 0.0027
Loa Loa (eye worm) cysteine protease 0.1364 0.3965 0.4414
Giardia lamblia Cathepsin B precursor 0.027 0.071 0.2535
Loa Loa (eye worm) Ulp1 protease 0.0103 0.0213 0.0237
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0148 0.0347 0.0817
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0409 0.1122 0.125
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0043 0.0035 0.0076
Leishmania major GPI-anchor transamidase subunit 8 (GPI8), putative 0.0708 0.2012 0.2385
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.027 0.071 0.0764
Entamoeba histolytica cysteine protease, putative 0.0722 0.2057 0.5153
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0043 0.0035 0.0011
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0082 0.0152 0.0141
Brugia malayi CHE-14 protein 0.0042 0.0032 0.0036
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0148 0.0347 0.0359
Plasmodium falciparum serine repeat antigen 5 0.027 0.071 0.1756
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0028 0.0031
Leishmania major cathepsin L-like protease 0.1364 0.3965 0.4718
Plasmodium falciparum cysteine proteinase falcipain 3 0.1364 0.3965 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2849 0.8385 1
Giardia lamblia Encystation-specific protease 0.027 0.071 0.2535
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0082 0.0091
Entamoeba histolytica cysteine proteinase, putative 0.1364 0.3965 1
Echinococcus granulosus sentrin specific protease 7 0.0194 0.0484 0.1139
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0028 0.0027
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0148 0.0347 0.0359
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.305 0.8982 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0148 0.0347 0.0359
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0005 0.0012
Giardia lamblia Hypothetical protein 0.027 0.071 0.2535
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2849 0.8385 1
Echinococcus multilocularis cathepsin L 0.027 0.071 0.1672
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0453 0.1253 0.1395
Onchocerca volvulus Cathepsin F homolog 0.1364 0.3965 0.4411
Schistosoma mansoni hemoglobinase (C13 family) 0.305 0.8982 1
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.0347 0.0359
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0944 0.2716 0.3004
Plasmodium vivax unspecified product 0.027 0.071 0.1779
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0313 0.0837 0.0932
Loa Loa (eye worm) Ulp1 protease 0.0043 0.0035 0.0039
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0082 0.0192
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1364 0.3965 0.4398
Echinococcus granulosus cathepsin L cysteine proteinase 0.1364 0.3965 0.9339
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.027 0.071 0.079
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.0078 0.0086
Brugia malayi Inositol-1 0.0082 0.0152 0.0169
Loa Loa (eye worm) hypothetical protein 0.0169 0.0409 0.0456
Plasmodium falciparum serine repeat antigen 4 0.027 0.071 0.1756
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.027 0.071 0.079
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0107 0.012
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0028 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1364 0.3965 0.4398
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0016 0.0013
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0194 0.0484 0.0538
Entamoeba histolytica cysteine protease, putative 0.0722 0.2057 0.5153
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0085 0.016 0.0135
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0216 0.0549 0.0525
Schistosoma mansoni hypothetical protein 0.017 0.0411 0.0458
Schistosoma mansoni caspase-7 (C14 family) 0.0234 0.0602 0.0671
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0108 0.0228 0.0618
Plasmodium falciparum GPI-anchor transamidase, putative 0.0708 0.2012 0.5056
Trypanosoma brucei trypanothione reductase 0.0085 0.016 0.0184
Plasmodium falciparum metacaspase-like protein 0.0148 0.0347 0.0837
Brugia malayi Papain family cysteine protease containing protein 0.027 0.071 0.079
Echinococcus granulosus GPI anchor transamidase 0.0708 0.2012 0.474
Entamoeba histolytica cysteine protease, putative 0.0722 0.2057 0.5153
Plasmodium falciparum cysteine proteinase falcipain 1 0.0722 0.2057 0.5167
Giardia lamblia Cathepsin L-like protease 0.027 0.071 0.2535
Entamoeba histolytica cysteine protease, putative 0.0722 0.2057 0.5153
Toxoplasma gondii thioredoxin reductase 0.0085 0.016 0.0391
Loa Loa (eye worm) hypothetical protein 0.0911 0.2618 0.2914
Brugia malayi beta-lactamase family protein 0.004 0.0026 0.0029
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0148 0.0347 0.0863
Brugia malayi Cathepsin L-like precursor 0.0911 0.2618 0.2914
Echinococcus granulosus cathepsin b 0.0409 0.1122 0.2644
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0037 0.0016 0.0028
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0148 0.0347 0.0386
Entamoeba histolytica cytidine deaminase, putative 0.013 0.0292 0.0671
Brugia malayi fibroinase precursor 0.027 0.071 0.079
Toxoplasma gondii cathepsin B 0.0313 0.0837 0.2101
Giardia lamblia Cathepsin L precursor 0.027 0.071 0.2535
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0183 0.0452 0.1065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1364 0.3965 0.4398
Toxoplasma gondii cathepsin CPC2 0.027 0.071 0.1779
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0028 0.0003
Trichomonas vaginalis cytidine deaminase, putative 0.013 0.0292 0.0298
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1364 0.3965 0.4414
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0026 0.006
Echinococcus multilocularis dna polymerase eta 0.0041 0.0028 0.0066
Loa Loa (eye worm) TK/ROR protein kinase 0.0037 0.0016 0.0018
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0107 0.012
Onchocerca volvulus 0.0169 0.0409 0.045
Echinococcus granulosus dna polymerase kappa 0.0041 0.0028 0.0066
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0005 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0701 0.1994 0.2198
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0148 0.0347 0.0863
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0313 0.0837 0.0906
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0251 0.0654 0.0728
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0028 0.0027
Toxoplasma gondii cathepsin CPC1 0.027 0.071 0.1779
Entamoeba histolytica cysteine protease, putative 0.027 0.071 0.1731
Brugia malayi Papain family cysteine protease containing protein 0.027 0.071 0.079
Loa Loa (eye worm) hypothetical protein 0.004 0.0026 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0005 0.0006
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0043 0.0035 0.0011
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0102 0.021 0.0234
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0202 0.0225
Loa Loa (eye worm) hypothetical protein 0.0043 0.0035 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.0347 0.0359
Schistosoma mansoni hypothetical protein 0.2342 0.6876 0.7655
Entamoeba histolytica cysteine proteinase, putative 0.0722 0.2057 0.5153
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0032 0.0036
Trypanosoma brucei metacaspase 5, putative 0.0148 0.0347 0.0408
Plasmodium vivax serine-repeat antigen (SERA) 0.027 0.071 0.1779
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.027 0.071 0.1779
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0107 0.0258
Leishmania major trypanothione reductase 0.0085 0.016 0.0172
Trypanosoma cruzi metacaspase 5, putative 0.0148 0.0347 0.0408
Schistosoma mansoni cathepsin S (C01 family) 0.027 0.071 0.079
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0043 0.0035 0.0018
Onchocerca volvulus 0.1364 0.3965 0.4411
Entamoeba histolytica cysteine proteinase, putative 0.0722 0.2057 0.5153
Loa Loa (eye worm) hypothetical protein 0.0453 0.1253 0.1395
Echinococcus multilocularis cathepsin b 0.0409 0.1122 0.2644
Loa Loa (eye worm) hypothetical protein 0.0041 0.0028 0.0031
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0082 0.0091
Brugia malayi cathepsin L precursor 0.027 0.071 0.079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.027 0.071 0.0764
Leishmania major hypothetical protein, conserved 0.004 0.0026 0.0011
Loa Loa (eye worm) hypothetical protein 0.0251 0.0654 0.0728
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0159 0.038 0.0446
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0028 0.0027
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0453 0.1253 0.1395
Loa Loa (eye worm) hypothetical protein 0.004 0.0026 0.0029
Echinococcus granulosus cathepsin l1 0.0911 0.2618 0.6166
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0944 0.2716 0.3004
Mycobacterium leprae PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE) 0.013 0.0292 0.0814
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.2396 0.7038 0.8393
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.305 0.8982 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0202 0.0225
Brugia malayi Cathepsin L-like precursor 0.1364 0.3965 0.4414
Trypanosoma cruzi metacaspase, putative 0.0148 0.0347 0.0408
Plasmodium vivax sentrin-specific protease 2, putative 0.0043 0.0035 0.0076
Leishmania major cytidine deaminase-like protein 0.013 0.0292 0.033
Schistosoma mansoni transcription factor LCR-F1 0.0185 0.0456 0.0508
Treponema pallidum fructose-bisphosphate aldolase 0.0944 0.2716 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0107 0.0253
Trypanosoma cruzi cruzipain precursor, putative 0.0453 0.1253 0.1489
Loa Loa (eye worm) inositol-1 0.0082 0.0152 0.0169
Entamoeba histolytica hypothetical protein 0.027 0.071 0.1731
Plasmodium falciparum serine repeat antigen 6 0.027 0.071 0.1756
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0082 0.0152 0.1005
Loa Loa (eye worm) hypothetical protein 0.027 0.071 0.079
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.027 0.071 0.079
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1364 0.3965 0.4398
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.021 0.0234
Giardia lamblia Cysteine protease 0.027 0.071 0.2535
Echinococcus multilocularis GPI anchor transamidase 0.0708 0.2012 0.474
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1364 0.3965 0.4398
Entamoeba histolytica papain family cysteine protease domain containing protein 0.027 0.071 0.1731
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0026 0.0024
Brugia malayi Cathepsin L-like precursor 0.1364 0.3965 0.4414
Plasmodium vivax vivapain-2 0.1364 0.3965 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0005 0.0012
Onchocerca volvulus 0.0043 0.0035 0.0033
Leishmania major cathepsin L-like protease 0.1364 0.3965 0.4718
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0028 0.0066
Loa Loa (eye worm) hypothetical protein 0.1364 0.3965 0.4414
Brugia malayi Cathepsin L-like precursor 0.1364 0.3965 0.4414
Echinococcus granulosus cathepsin L 0.0722 0.2057 0.4844
Brugia malayi jmjC domain containing protein 0.0059 0.0082 0.0091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2849 0.8385 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0028 0.0027
Echinococcus granulosus dna polymerase eta 0.0041 0.0028 0.0066
Echinococcus granulosus sentrin specific protease 1 0.0043 0.0035 0.0083
Brugia malayi beta-lactamase 0.004 0.0026 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0028 0.0027
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.021 0.0495
Brugia malayi Cathepsin L-like cysteine proteinase 0.0911 0.2618 0.2914
Leishmania major cathepsin L-like protease 0.2849 0.8385 1
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0108 0.0228 0.0842
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.027 0.071 0.079
Brugia malayi cathepsin F-like cysteine proteinase 0.0453 0.1253 0.1395
Loa Loa (eye worm) hypothetical protein 0.0453 0.1253 0.1395
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0043 0.0035 0.0011
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3113 0.917 0.9168
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0204 0.0227
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0047 0.005
Giardia lamblia Cathepsin L-like protease 0.027 0.071 0.2535
Schistosoma mansoni family C13 non-peptidase homologue (C13 family) 0.305 0.8982 1
Plasmodium vivax serine-repeat antigen (SERA) 0.027 0.071 0.1779
Schistosoma mansoni inositol monophosphatase 0.0082 0.0152 0.0169
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0028 0.0027
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0387 0.1057 0.8231
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0028 0.0003
Trypanosoma cruzi metacaspase, putative 0.0148 0.0347 0.0408
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0722 0.2057 0.229
Onchocerca volvulus 0.004 0.0026 0.0023
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0028 0.0027
Mycobacterium ulcerans recombinase A 0.0108 0.0228 0.1613
Entamoeba histolytica hypothetical protein 0.0185 0.0456 0.1088
Giardia lamblia Cathepsin B precursor 0.0313 0.0837 0.301
Entamoeba histolytica cysteine protease, putative 0.0722 0.2057 0.5153
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.027 0.071 0.1779
Brugia malayi Cathepsin L-like precursor 0.0911 0.2618 0.2914
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0005 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.027 0.071 0.0764
Entamoeba histolytica cysteine protease, putative 0.0722 0.2057 0.5153
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0082 0.0152 0.0174
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0103 0.0213 0.0209
Onchocerca volvulus 0.013 0.0292 0.032
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0026 0.0029
Leishmania major DNA polymerase eta, putative 0.0041 0.0028 0.0014
Mycobacterium leprae Conserved hypothetical protein 0.114 0.33 1
Brugia malayi cathepsin L-like cysteine proteinase 0.027 0.071 0.079
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0313 0.0837 0.0981
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0107 0.0253
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.027 0.071 0.1756
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0387 0.1057 1
Mycobacterium tuberculosis Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) 0.013 0.0292 0.0267
Echinococcus granulosus microtubule associated protein 2 0.1458 0.4245 1
Echinococcus granulosus expressed conserved protein 0.0093 0.0182 0.0429
Loa Loa (eye worm) hypothetical protein 0.027 0.071 0.079
Trypanosoma cruzi cysteine proteinase, putative 0.0722 0.2057 0.2448
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0082 0.0152 0.0174
Leishmania major cathepsin L-like protease 0.2849 0.8385 1
Echinococcus granulosus cathepsin L 0.027 0.071 0.1672
Echinococcus granulosus caspase 0.0148 0.0347 0.0817
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0722 0.2057 0.229
Trypanosoma cruzi major cysteine proteinase, putative 0.027 0.071 0.084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1364 0.3965 0.4398
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.027 0.071 0.0764
Brugia malayi Cell death protein 3 precursor 0.0234 0.0602 0.0671
Giardia lamblia Cathepsin L precursor 0.027 0.071 0.2535
Loa Loa (eye worm) hypothetical protein 0.0099 0.02 0.0222
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0461 0.1279 0.3828
Leishmania major metacaspase, putative 0.0148 0.0347 0.0395
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0409 0.1122 0.125
Echinococcus multilocularis caspase 2 0.0234 0.0602 0.1419
Brugia malayi Cathepsin L-like precursor 0.1364 0.3965 0.4414
Plasmodium vivax unspecified product 0.0722 0.2057 0.5181
Schistosoma mansoni hypothetical protein 0.0185 0.0456 0.0508
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0336 0.0906 0.1075
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0018
Onchocerca volvulus 0.004 0.0026 0.0023
Leishmania major cathepsin L-like protease 0.1364 0.3965 0.4718
Schistosoma mansoni caspase-7 (C14 family) 0.0148 0.0347 0.0386
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0231 0.0595 0.0663
Toxoplasma gondii kringle domain-containing protein 0.0037 0.0016 0.0028
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0103 0.0213 0.0237
Echinococcus granulosus caspase 2 0.0234 0.0602 0.1419
Schistosoma mansoni Replicative DNA helicase 0.0387 0.1057 0.1177
Entamoeba histolytica papain family cysteine protease domain containing protein 0.027 0.071 0.1731
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1364 0.3965 0.4398
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0043 0.0035 0.0011
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0043 0.0035 0.0018
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.027 0.071 0.1779
Giardia lamblia Hypothetical protein 0.027 0.071 0.2535
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.305 0.8982 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0028 0.0066
Giardia lamblia Dipeptidyl-peptidase I precursor 0.027 0.071 0.2535
Giardia lamblia Sentrin specific protease, putative 0.0043 0.0035 0.0026
Echinococcus multilocularis cysteine protease 0.1364 0.3965 0.9339
Mycobacterium tuberculosis Probable reductase 0.0194 0.0485 0.046
Trypanosoma cruzi cysteine peptidase, putative 0.2849 0.8385 1
Entamoeba histolytica cysteine protease, putative 0.0722 0.2057 0.5153
Echinococcus multilocularis protein patched 0.0042 0.0032 0.0076
Schistosoma mansoni inositol monophosphatase 0.0082 0.0152 0.0169
Brugia malayi hypothetical protein 0.0169 0.0409 0.0456
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0035 0.0011
Trypanosoma brucei metacaspase MCA3 0.0148 0.0347 0.0408
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.027 0.071 0.1779
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0107 0.0652
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0911 0.2618 0.2894
Onchocerca volvulus Legumain homolog 0.305 0.8982 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0409 0.1122 0.1333
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0043 0.0035 0.0011
Plasmodium falciparum serine repeat antigen 2 0.027 0.071 0.1756
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0028 0.0031
Giardia lamblia Cathepsin B precursor 0.027 0.071 0.2535
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0944 0.2716 0.3004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1364 0.3965 0.4398
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0216 0.0549 0.1599
Entamoeba histolytica cysteine proteinase, putative 0.0722 0.2057 0.5153
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0028 0.0003
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0043 0.0035 0.0076
Plasmodium vivax serine-repeat antigen (SERA), putative 0.027 0.071 0.1779
Chlamydia trachomatis replicative DNA helicase 0.0387 0.1057 1
Brugia malayi Kringle domain containing protein 0.0037 0.0016 0.0018
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0409 0.1122 0.125
Trypanosoma cruzi cysteine protease, putative 0.0722 0.2057 0.2448
Giardia lamblia GPI-anchor transamidase, putative 0.0708 0.2012 0.7381
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0722 0.2057 0.229
Plasmodium falciparum serine repeat antigen 1 0.027 0.071 0.1756
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0047 0.005
Schistosoma mansoni hypothetical protein 0.0041 0.0028 0.0031
Brugia malayi glutathione reductase 0.0085 0.016 0.0178
Echinococcus multilocularis geminin 0.017 0.0411 0.0969
Loa Loa (eye worm) peptidase C13 family protein 0.305 0.8982 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0722 0.2057 0.2448
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0043 0.0035 0.0039
Onchocerca volvulus 0.027 0.071 0.0785
Giardia lamblia Cathepsin B precursor 0.027 0.071 0.2535
Brugia malayi Pre-SET motif family protein 0.0231 0.0595 0.0663
Onchocerca volvulus Cathepsin L homolog 0.027 0.071 0.0785
Giardia lamblia Cathepsin B precursor 0.0313 0.0837 0.301
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.021 0.0495
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0256 0.0668 0.0644
Schistosoma mansoni caspase-3 (C14 family) 0.0148 0.0347 0.0386
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0043 0.0035 0.0039
Onchocerca volvulus 0.013 0.0292 0.032
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0026 0.0029
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0043 0.0035 0.0018
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0032 0.0076
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0944 0.2716 0.6829
Trypanosoma cruzi cysteine peptidase, putative 0.0453 0.1253 0.1489
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1364 0.3965 0.4398
Schistosoma mansoni glycosylphosphatidylinositol:protein transamidase (C13 family) 0.0708 0.2012 0.224
Giardia lamblia Cathepsin B precursor 0.027 0.071 0.2535
Brugia malayi Cathepsin L-like precursor 0.1364 0.3965 0.4414
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0032 0.0007
Mycobacterium ulcerans hypothetical protein 0.0177 0.0433 0.3249
Trypanosoma brucei Metacaspase-4 0.0148 0.0347 0.0408
Onchocerca volvulus 0.1364 0.3965 0.4411
Plasmodium falciparum metacaspase 1 0.0148 0.0347 0.0837
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2849 0.8385 1
Onchocerca volvulus 0.004 0.0026 0.0023
Loa Loa (eye worm) hypothetical protein 0.0033 0.0005 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1364 0.3965 0.4398
Trypanosoma cruzi cysteine peptidase, putative 0.2849 0.8385 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0194 0.0485 0.046
Mycobacterium tuberculosis Conserved hypothetical protein 0.0177 0.0433 0.0408
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0028 0.0027
Treponema pallidum replicative DNA helicase (dnaB) 0.0387 0.1057 0.3334
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0701 0.1994 0.2198
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0326 0.0767
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0026 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0944 0.2716 0.3004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2849 0.8385 1
Entamoeba histolytica hypothetical protein 0.0185 0.0456 0.1088
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0026 0.0024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0701 0.1994 0.2198
Entamoeba histolytica cysteine proteinase, putative 0.0911 0.2618 0.6578
Entamoeba histolytica cysteine protease, putative 0.0722 0.2057 0.5153
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0028 0.0027
Onchocerca volvulus 0.1364 0.3965 0.4411
Entamoeba histolytica cysteine protease, putative 0.027 0.071 0.1731
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0028 0.0027
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0103 0.0213 0.0237
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.027 0.071 0.0764
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0148 0.0347 0.0817
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1364 0.3965 0.4398
Trypanosoma cruzi cysteine peptidase, Clan CD, family C13, putative 0.0708 0.2012 0.2395
Trypanosoma cruzi metacaspase 5, putative 0.0148 0.0347 0.0408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0722 0.2057 0.2448
Brugia malayi Papain family cysteine protease containing protein 0.0722 0.2057 0.229
Plasmodium vivax glutathione reductase, putative 0.0085 0.016 0.0391
Schistosoma mansoni microtubule-associated protein tau 0.1458 0.4245 0.4726
Schistosoma mansoni hypothetical protein 0.0068 0.0108 0.0121
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.027 0.071 0.0764
Trypanosoma brucei cytidine deaminase 0.013 0.0292 0.0342
Entamoeba histolytica cysteine protease, putative 0.027 0.071 0.1731
Loa Loa (eye worm) hypothetical protein 0.0043 0.0035 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.0347 0.0359
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0313 0.0837 0.0993
Echinococcus multilocularis cathepsin L cysteine protease 0.1364 0.3965 0.9339
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2849 0.8385 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0148 0.0347 0.0359
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0028 0.0027
Echinococcus granulosus neuropeptide receptor A26 0.0473 0.1313 0.3093
Leishmania major cathepsin L-like protease 0.2849 0.8385 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0944 0.2716 0.3004
Plasmodium vivax unspecified product 0.0453 0.1253 0.3152
Toxoplasma gondii preprocathepsin c precursor, putative 0.027 0.071 0.1779
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0028 0.0003
Echinococcus multilocularis microtubule associated protein 2 0.1458 0.4245 1
Plasmodium vivax GPI-anchor transamidase, putative 0.0708 0.2012 0.5069
Giardia lamblia Fructose-bisphosphate aldolase 0.0944 0.2716 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2849 0.8385 1
Plasmodium falciparum serine repeat antigen 8 0.027 0.071 0.1756
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0148 0.0347 0.0359
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.027 0.071 0.0764
Loa Loa (eye worm) hypothetical protein 0.0911 0.2618 0.2914
Trypanosoma cruzi metacaspase, putative 0.0148 0.0347 0.0408
Loa Loa (eye worm) hypothetical protein 0.004 0.0026 0.0029
Plasmodium vivax hypothetical protein, conserved 0.004 0.0026 0.0051
Brugia malayi cahepsin L-like non-peptiedase homolog 0.027 0.071 0.079
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.305 0.8982 1
Plasmodium vivax thioredoxin reductase, putative 0.0085 0.016 0.0391
Loa Loa (eye worm) hypothetical protein 0.0068 0.0108 0.0121
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.027 0.071 0.1779
Giardia lamblia Cathepsin L precursor 0.027 0.071 0.2535
Entamoeba histolytica hypothetical protein 0.0185 0.0456 0.1088
Entamoeba histolytica hypothetical protein 0.0185 0.0456 0.1088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.027 0.071 0.0764
Plasmodium falciparum serine repeat antigen 7 0.027 0.071 0.1756
Entamoeba histolytica cysteine protease, putative 0.0722 0.2057 0.5153
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0028 0.0027
Trypanosoma cruzi metacaspase, putative 0.0148 0.0347 0.0408
Onchocerca volvulus Cell death protein 3 homolog 0.0234 0.0602 0.0665
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0183 0.0452 0.1065
Onchocerca volvulus 0.0037 0.0016 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2849 0.8385 1
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0082 0.0192
Leishmania major cathepsin L-like protease 0.1364 0.3965 0.4718
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1364 0.3965 0.9339
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0082 0.0152 0.0162
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0005 0.0012
Echinococcus granulosus neuropeptide s receptor 0.0473 0.1313 0.3093
Schistosoma mansoni hypothetical protein 0.017 0.0411 0.0458
Echinococcus multilocularis tissue type plasminogen activator 0.0037 0.0016 0.0038
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0028 0.0031
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0194 0.0484 0.1157
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0043 0.0035 0.0039
Entamoeba histolytica cysteine proteinase, putative 0.0722 0.2057 0.5153
Schistosoma mansoni hypothetical protein 0.0041 0.0028 0.0031
Trichomonas vaginalis cytidine deaminase, putative 0.013 0.0292 0.0298
Brugia malayi GPI-anchor transamidase 0.0708 0.2012 0.224
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.027 0.071 0.0764
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0944 0.2716 0.3004
Plasmodium falciparum serine repeat antigen 3 0.027 0.071 0.1756
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.305 0.8982 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0944 0.2716 0.3004
Echinococcus multilocularis cathepsin L cysteine protease 0.1364 0.3965 0.9339
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0148 0.0347 0.0359
Trypanosoma cruzi hypothetical protein 0.0103 0.0213 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.0347 0.0359
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0082 0.0152 0.0141
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0194 0.0485 0.046
Plasmodium vivax vivapain-3 0.0722 0.2057 0.5181
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0082 0.0152 0.037
Giardia lamblia Cysteine protease 0.027 0.071 0.2535
Mycobacterium ulcerans cytidine deaminase 0.013 0.0292 0.2127
Loa Loa (eye worm) papain family cysteine protease containing protein 0.027 0.071 0.079
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0701 0.1994 0.222
Brugia malayi cathepsin Z-like cysteine proteinase 0.0701 0.1994 0.222
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0159 0.038 0.0434
Echinococcus multilocularis expressed conserved protein 0.0151 0.0355 0.0836
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0028 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1364 0.3965 0.4398
Leishmania major cysteine peptidase A (CPA) 0.1364 0.3965 0.4718
Giardia lamblia Cathepsin L precursor 0.027 0.071 0.2535
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0216 0.0549 0.0525
Giardia lamblia Cysteine protease 0.027 0.071 0.2535
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0911 0.2618 0.2894
Leishmania major DNA polymerase kappa, putative 0.0041 0.0028 0.0014
Leishmania major cathepsin L-like protease 0.1364 0.3965 0.4718
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0103 0.0213 0.047
Echinococcus granulosus apoptotic protease activating factor 1 0.0086 0.0162 0.0381
Trypanosoma brucei GPI-anchor transamidase subunit 8 (GPI8) 0.0708 0.2012 0.2395
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0043 0.0035 0.0011
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0194 0.0485 0.046
Schistosoma mansoni hypothetical protein 0.0086 0.0162 0.018
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.027 0.071 0.1756
Trypanosoma brucei cysteine peptidase C (CPC) 0.0313 0.0837 0.0993
Loa Loa (eye worm) hypothetical protein 0.0086 0.0162 0.018
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0185 0.0456 0.1075
Brugia malayi Papain family cysteine protease containing protein 0.1364 0.3965 0.4414
Brugia malayi Peptidase C13 family protein 0.305 0.8982 1
Trypanosoma brucei DNA polymerase eta, putative 0.0041 0.0028 0.0027
Schistosoma mansoni cathepsin B (C01 family) 0.027 0.071 0.079
Brugia malayi hypothetical protein 0.0086 0.0162 0.018
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0032 0.0076
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.027 0.071 0.079
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.027 0.071 0.079
Chlamydia trachomatis recombinase RecA 0.0108 0.0228 0.1885
Plasmodium vivax serine-repeat antigen (SERA), putative 0.027 0.071 0.1779
Loa Loa (eye worm) hypothetical protein 0.004 0.0026 0.0029
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0722 0.2057 0.2448
Echinococcus granulosus caspase 8 0.0148 0.0347 0.0817
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0043 0.0035 0.0023
Brugia malayi hypothetical protein 0.0185 0.0456 0.0508
Giardia lamblia Cathepsin B precursor 0.0701 0.1994 0.7314
Schistosoma mansoni hypothetical protein 0.0037 0.0016 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1364 0.3965 0.4398
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1364 0.3965 0.4398
Loa Loa (eye worm) hypothetical protein 0.0708 0.2012 0.224
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0102 0.021 0.0234
Giardia lamblia Dipeptidyl-peptidase I precursor 0.027 0.071 0.2535
Echinococcus multilocularis thioredoxin glutathione reductase 0.0086 0.0162 0.038
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0082 0.0192
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1364 0.3965 0.4398
Brugia malayi beta-lactamase family protein 0.004 0.0026 0.0029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.021 0.0495
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1364 0.3965 0.4398
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0326 0.0767
Echinococcus granulosus cathepsin l cysteine peptidase 0.1364 0.3965 0.9339
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0336 0.0906 0.1075
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.027 0.071 0.1756
Loa Loa (eye worm) hypothetical protein 0.0409 0.1122 0.125
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1364 0.3965 0.9339
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0944 0.2716 0.6829
Brugia malayi cathepsin F-like cysteine proteinase 0.027 0.071 0.079
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0107 0.0652
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.0347 0.0359
Loa Loa (eye worm) hypothetical protein 0.0453 0.1253 0.1395
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.027 0.071 0.079
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0148 0.0347 0.0386
Giardia lamblia Cathepsin L precursor 0.027 0.071 0.2535
Trypanosoma cruzi cysteine peptidase, putative 0.2849 0.8385 1
Echinococcus multilocularis cathepsin L 0.0722 0.2057 0.4844
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0028 0.0014
Echinococcus granulosus thioredoxin glutathione reductase 0.0086 0.0162 0.038
Giardia lamblia Cathepsin B precursor 0.0313 0.0837 0.301
Echinococcus granulosus inositol monophosphatase 1 0.0082 0.0152 0.0357
Trypanosoma cruzi cysteine peptidase, putative 0.1364 0.3965 0.4725
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1364 0.3965 0.4398
Trypanosoma brucei SUMO1/Ulp2, putative 0.0043 0.0035 0.0036
Onchocerca volvulus Cathepsin L homolog 0.1364 0.3965 0.4411
Brugia malayi cathepsin Z-like cysteine proteinase 0.0701 0.1994 0.222
Loa Loa (eye worm) hypothetical protein 0.027 0.071 0.079
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0461 0.1279 0.1257
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0026 0.006
Echinococcus multilocularis cysteine protease 0.1364 0.3965 0.9339
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0026 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0005 0.0006
Entamoeba histolytica cysteine proteinase 1, putative 0.0722 0.2057 0.5153
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.0708 0.2012 0.2218
Echinococcus multilocularis sentrin specific protease 1 0.0043 0.0035 0.0083
Trypanosoma cruzi cytidine deaminase-like protein 0.013 0.0292 0.0342
Echinococcus granulosus expressed conserved protein 0.0151 0.0355 0.0836
Entamoeba histolytica cysteine protease, putative 0.027 0.071 0.1731
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0701 0.1994 0.2198
Toxoplasma gondii cathepsin CPL 0.1364 0.3965 1
Loa Loa (eye worm) glutathione reductase 0.0085 0.016 0.0178
Loa Loa (eye worm) thioredoxin reductase 0.0085 0.016 0.0178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1364 0.3965 0.4398
Trypanosoma brucei metacaspase 0.0148 0.0347 0.0408
Echinococcus multilocularis sentrin specific protease 7 0.0194 0.0484 0.1139
Echinococcus multilocularis protein dispatched 1 0.0048 0.005 0.0118
Schistosoma mansoni cathepsin F (C01 family) 0.1364 0.3965 0.4414
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0043 0.0035 0.0018
Loa Loa (eye worm) fibroinase 0.1364 0.3965 0.4414
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0043 0.0035 0.0039
Plasmodium falciparum sentrin-specific protease 1 0.0043 0.0035 0.0048
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0194 0.0485 0.046
Brugia malayi cytidine deaminase, identical 0.013 0.0292 0.0325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0722 0.2057 0.2268
Schistosoma mansoni hypothetical protein 0.0041 0.0028 0.0031
Brugia malayi Papain family cysteine protease containing protein 0.0722 0.2057 0.229
Brugia malayi cathepsin L-like precursor 0.0911 0.2618 0.2914
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.0107 0.0082
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0159 0.038 0.0446
Brugia malayi Papain family cysteine protease containing protein 0.027 0.071 0.079
Loa Loa (eye worm) hypothetical protein 0.027 0.071 0.079
Entamoeba histolytica cysteine proteinase 2 0.0722 0.2057 0.5153
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0194 0.0485 0.1402
Echinococcus granulosus cytidine deaminase 0.013 0.0292 0.0688
Trypanosoma brucei metacaspase MCA2 0.0148 0.0347 0.0408
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.021 0.0234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2849 0.8385 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.02 0.0436
Schistosoma mansoni cathepsin F (C01 family) 0.0911 0.2618 0.2914
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1364 0.3965 0.4398
Mycobacterium tuberculosis Probable oxidoreductase 0.0216 0.0549 0.0525
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0461 0.1279 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.02 0.047
Echinococcus granulosus cathepsin L cysteine protease 0.0722 0.2057 0.4844
Loa Loa (eye worm) ctsf protein 0.1364 0.3965 0.4414
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1364 0.3965 0.4398
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0148 0.0347 0.0359
Plasmodium vivax vivapain-1 0.0722 0.2057 0.5181
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1364 0.3965 0.4398
Onchocerca volvulus 0.1364 0.3965 0.4411
Entamoeba histolytica cysteine protease, putative 0.027 0.071 0.1731
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0103 0.0213 0.0209
Echinococcus multilocularis neuropeptide s receptor 0.0473 0.1313 0.3093
Entamoeba histolytica cysteine protease, putative 0.1364 0.3965 1
Trypanosoma cruzi major cysteine proteinase, putative 0.1755 0.513 0.6116
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.027 0.071 0.0764
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.02 0.0222
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.305 0.8982 1
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.0347 0.0359
Echinococcus granulosus geminin 0.017 0.0411 0.0969
Schistosoma mansoni hemoglobinase (C13 family) 0.305 0.8982 1
Onchocerca volvulus 0.1364 0.3965 0.4411
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0028 0.0031
Echinococcus granulosus cathepsin l1 0.1364 0.3965 0.9339
Schistosoma mansoni cathepsin s 0.0453 0.1253 0.1395
Echinococcus multilocularis apoptotic protease activating factor 1 0.0086 0.0162 0.0381
Entamoeba histolytica cysteine proteinase, putative 0.1364 0.3965 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0194 0.0485 0.046
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0028 0.002
Loa Loa (eye worm) hypothetical protein 0.004 0.0026 0.0029
Plasmodium vivax hypothetical protein, conserved 0.0148 0.0347 0.0863
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.021 0.0234
Brugia malayi Protein kinase domain containing protein 0.0037 0.0016 0.0018
Loa Loa (eye worm) hypothetical protein 0.0911 0.2618 0.2914
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0043 0.0035 0.0076
Plasmodium vivax vivapain-2 0.1364 0.3965 1
Echinococcus multilocularis cathepsin b 0.0409 0.1122 0.2644
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1364 0.3965 0.4398
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0032 0.0076
Giardia lamblia Cathepsin L precursor 0.027 0.071 0.2535
Giardia lamblia Dipeptidyl-peptidase I precursor 0.027 0.071 0.2535
Trypanosoma brucei unspecified product 0.0041 0.0028 0.0027
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0387 0.1057 0.3151
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1364 0.3965 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1364 0.3965 1
Brugia malayi Pre-SET motif family protein 0.0033 0.0005 0.0006
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0028 0.0031
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0074 0.0126 0.0306
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0082 0.0152 0.0314
Echinococcus granulosus cysteine protease 0.0722 0.2057 0.4844
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0002 0.0004
Entamoeba histolytica cysteine protease, putative 0.0722 0.2057 0.5153
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.027 0.071 0.2535
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0028 0.0027
Echinococcus multilocularis neuropeptide receptor A26 0.0473 0.1313 0.3093
Trypanosoma cruzi cruzipain precursor, putative 0.2849 0.8385 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0148 0.0347 0.0359
Entamoeba histolytica GPI-anchor transamidase, putative 0.0708 0.2012 0.5041
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0409 0.1122 0.125
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1364 0.3965 0.4398
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.027 0.071 0.079
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0082 0.0091
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0148 0.0347 0.0863
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0148 0.0347 0.0359
Echinococcus multilocularis caspase 8 0.0148 0.0347 0.0817
Onchocerca volvulus Cathepsin L homolog 0.1364 0.3965 0.4411
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0028 0.0027
Brugia malayi Cathepsin L-like precursor 0.0453 0.1253 0.1395
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0107 0.0652
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0108 0.0121
Schistosoma mansoni cathepsin C 0.027 0.071 0.079
Onchocerca volvulus 0.1364 0.3965 0.4411
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1364 0.3965 0.4398
Entamoeba histolytica cysteine protease, putative 0.0722 0.2057 0.5153
Trypanosoma cruzi cysteine proteinase, putative 0.0722 0.2057 0.2448
Schistosoma mansoni patched 1 0.0042 0.0032 0.0036
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.02 0.047
Onchocerca volvulus 0.0086 0.0162 0.0174
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0043 0.0035 0.0011
Brugia malayi cathepsin B-like cysteine proteinase 0.0409 0.1122 0.125
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0043 0.0035 0.0039
Loa Loa (eye worm) cathepsin B 0.0313 0.0837 0.0932
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2849 0.8385 1
Echinococcus multilocularis expressed conserved protein 0.0093 0.0182 0.0429
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0074 0.0126 0.0101
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1364 0.3965 0.4398
Trichomonas vaginalis Sentrin-specific protease, putative 0.0103 0.0213 0.0209
Plasmodium falciparum glutathione reductase 0.0085 0.016 0.0364
Trichomonas vaginalis Clan CD, family C13, legumain-like cysteine peptidase 0.305 0.8982 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0336 0.0906 0.1075
Trypanosoma cruzi trypanothione reductase, putative 0.0085 0.016 0.0184
Loa Loa (eye worm) hypothetical protein 0.0234 0.0602 0.0671
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.027 0.071 0.0764
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1364 0.3965 0.4414
Onchocerca volvulus 0.0911 0.2618 0.291
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.027 0.071 0.0764

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.0000003 M Cytidine Deaminase Inhibition in mouse Kidney ChEMBL. 7401098
Ki (binding) = 0.0000003 M Binding affinity of the compound against cytidine deaminase of mouse kidney ChEMBL. 7252974
Ki (binding) = 0.0000004 M Cytidine Deaminase Inhibition in human liver ChEMBL. 7401098
Ki (binding) = 0.0000004 M Binding affinity of the compound against cytidine deaminase of human liver ChEMBL. 7252974
Ki (binding) = 400 nM Binding affinity for human cytidine deaminase ChEMBL. 15689149

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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