Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ap endonuclease | 0.0037 | 0.0089 | 0.0089 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0019 | 0.0019 |
Mycobacterium ulcerans | oxidoreductase | 0.0041 | 0.0106 | 0.0283 |
Loa Loa (eye worm) | beta-lactamase | 0.0075 | 0.0271 | 0.0661 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0141 | 0.0595 | 0.0595 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0075 | 0.0271 | 0.1682 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0041 | 0.0106 | 0.0076 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0122 | 0.0503 | 0.0503 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0304 | 0.0304 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0041 | 0.0106 | 0.0106 |
Onchocerca volvulus | 0.0047 | 0.0135 | 0.0181 | |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0037 | 0.0089 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0075 | 0.0271 | 0.3169 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0477 | 0.2227 | 1 |
Echinococcus granulosus | geminin | 0.034 | 0.1559 | 0.1559 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0047 | 0.0135 | 0.0135 |
Onchocerca volvulus | 0.0041 | 0.0106 | 0.0116 | |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0295 | 0.1341 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0075 | 0.0271 | 0.085 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0295 | 0.1341 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0167 | 0.0403 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0037 | 0.0089 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0304 | 0.0304 |
Echinococcus granulosus | synaptic vesicular amine transporter | 0.0186 | 0.0813 | 0.0813 |
Schistosoma mansoni | amine oxidase | 0.0041 | 0.0106 | 0.0106 |
Trichomonas vaginalis | esterase, putative | 0.0075 | 0.0271 | 0.04 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0053 | 0.0167 | 0.0404 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0081 | 0.0304 | 0.0304 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0037 | 0.0089 | 0.0213 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0346 | 0.1591 | 0.1591 |
Schistosoma mansoni | bromodomain containing protein | 0.007 | 0.0249 | 0.0249 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0055 | 0.0049 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0041 | 0.0106 | 0.0106 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0053 | 0.0167 | 0.0167 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0038 | 0.0093 | 0.0222 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0075 | 0.0271 | 0.0662 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0041 | 0.0106 | 0.0283 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0041 | 0.0106 | 0.0395 |
Echinococcus multilocularis | synaptic vesicular amine transporter | 0.0186 | 0.0813 | 0.0813 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0139 | 0.0586 | 0.4132 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0037 | 0.0089 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0304 | 0.0304 |
Leishmania major | hypothetical protein, conserved | 0.0075 | 0.0271 | 0.1682 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.0197 | 0.0503 |
Echinococcus granulosus | jumonji domain containing protein | 0.0041 | 0.0109 | 0.0109 |
Schistosoma mansoni | vesicular amine transporter | 0.0186 | 0.0813 | 0.0813 |
Plasmodium vivax | hypothetical protein, conserved | 0.0075 | 0.0271 | 0.4849 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.003 | 0.0053 | 0.0053 |
Echinococcus multilocularis | tumor protein p63 | 0.0327 | 0.1499 | 0.1499 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.0197 | 0.1105 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0135 | 0.0326 |
Schistosoma mansoni | microtubule-associated protein tau | 0.2076 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0041 | 0.011 | 0.0427 |
Echinococcus granulosus | tumor protein p63 | 0.0327 | 0.1499 | 0.1499 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.003 | 0.003 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0041 | 0.011 | 0.0427 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0038 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0106 | 0.0252 |
Toxoplasma gondii | ABC1 family protein | 0.0075 | 0.0271 | 0.4849 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0122 | 0.0503 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.0476 | 0.1166 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0229 | 0.1021 | 0.1021 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.0053 | 0.0123 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.045 | 0.2096 | 0.2096 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0041 | 0.0106 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0075 | 0.0271 | 0.3169 |
Mycobacterium ulcerans | dehydrogenase | 0.0041 | 0.0106 | 0.0283 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.0139 | 0.1924 |
Echinococcus multilocularis | peregrin | 0.0032 | 0.0065 | 0.0065 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.003 | 0.0053 | 0.0053 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0.0106 | 0.1177 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0346 | 0.1591 | 0.1591 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0041 | 0.0106 | 0.1177 |
Leishmania major | UDP-galactopyranose mutase | 0.0041 | 0.0106 | 0.0395 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0053 | 0.0053 |
Brugia malayi | Pre-SET motif family protein | 0.0853 | 0.4057 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0047 | 0.0135 | 0.0135 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0053 | 0.0167 | 0.0167 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0081 | 0.0304 | 0.0741 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0053 | 0.0122 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.0476 | 0.1166 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.0141 | 0.0141 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0075 | 0.0271 | 0.04 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0041 | 0.0106 | 0.0106 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.1021 | 0.2511 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0041 | 0.011 | 0.0427 |
Brugia malayi | mbt repeat family protein | 0.0047 | 0.0135 | 0.0327 |
Echinococcus multilocularis | GPCR, family 2 | 0.0081 | 0.0304 | 0.0304 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0141 | 0.034 |
Echinococcus multilocularis | zinc finger protein | 0.0022 | 0.0014 | 0.0014 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0047 | 0.0135 | 0.0181 |
Schistosoma mansoni | ap endonuclease | 0.0037 | 0.0089 | 0.0089 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0122 | 0.0503 | 0.0503 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0066 | 0.023 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0128 | 0.0306 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0041 | 0.0106 | 0.1177 |
Schistosoma mansoni | hypothetical protein | 0.0292 | 0.1326 | 0.1326 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0037 | 0.0089 | 0.0212 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0139 | 0.0586 | 0.4132 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0037 | 0.0089 | 0.0269 |
Loa Loa (eye worm) | PHD-finger family protein | 0.003 | 0.0053 | 0.0122 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0053 | 0.0167 | 0.0167 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0346 | 0.1591 | 0.3916 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0304 | 0.0741 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0041 | 0.0106 | 0.1177 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0075 | 0.0271 | 0.04 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0041 | 0.0106 | 0.1177 |
Echinococcus granulosus | GPCR family 2 | 0.0081 | 0.0304 | 0.0304 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0346 | 0.1591 | 0.1591 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0289 | 0.0705 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0041 | 0.0106 | 0.0076 |
Echinococcus multilocularis | neuropeptide s receptor | 0.045 | 0.2096 | 0.2096 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0192 | 0.084 | 0.084 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0853 | 0.4057 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0271 | 0.0661 |
Loa Loa (eye worm) | abnormal catecholamine distribution protein 1 | 0.0186 | 0.0813 | 0.1998 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0197 | 0.0197 |
Brugia malayi | beta-lactamase | 0.0075 | 0.0271 | 0.0662 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0075 | 0.0271 | 0.085 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0106 | 0.0252 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0047 | 0.0135 | 0.0135 |
Mycobacterium leprae | Probable lipase LipE | 0.0075 | 0.0271 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0346 | 0.1591 | 0.1591 |
Trichomonas vaginalis | set domain proteins, putative | 0.0971 | 0.463 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0038 | 0.0093 | 0.0223 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0041 | 0.0106 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0077 | 0.0284 | 0.0284 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0106 | 0.0254 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0141 | 0.0595 | 0.0595 |
Brugia malayi | hypothetical protein | 0.003 | 0.0055 | 0.0128 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0038 | 0.0093 | 0.0093 |
Brugia malayi | Pre-SET motif family protein | 0.0122 | 0.0503 | 0.1234 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0037 | 0.0089 | 0.6934 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0122 | 0.0503 | 0.0503 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0431 | 0.2002 | 0.493 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.0102 | 0.0102 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0097 | 0.0381 | 0.0381 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0037 | 0.0089 | 0.0269 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0197 | 0.1876 |
Echinococcus multilocularis | pol protein | 0.0634 | 0.2992 | 0.2992 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0139 | 0.0586 | 0.4132 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0106 | 0.0252 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.003 | 0.003 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0041 | 0.0106 | 0.0106 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0271 | 0.0661 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0138 | 0.0332 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0075 | 0.0271 | 0.3169 |
Mycobacterium ulcerans | lipase LipD | 0.0075 | 0.0271 | 0.3169 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.0763 | 0.0763 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0271 | 0.0661 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0081 | 0.0304 | 0.0304 |
Brugia malayi | jmjC domain containing protein | 0.0097 | 0.0381 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0271 | 0.0661 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0271 | 0.0661 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0925 | 0.4407 | 0.4407 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0075 | 0.0271 | 0.0271 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0304 | 0.0304 |
Toxoplasma gondii | exonuclease III APE | 0.0037 | 0.0089 | 0.0816 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0081 | 0.0304 | 0.0742 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0075 | 0.0271 | 0.1682 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0041 | 0.0106 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0075 | 0.0271 | 0.0662 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0097 | 0.0381 | 0.0381 |
Brugia malayi | Abnormal catecholamine distribution protein 1 | 0.0186 | 0.0813 | 0.1999 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0037 | 0.0089 | 0.0816 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0037 | 0.0089 | 0.0269 |
Plasmodium vivax | SET domain protein, putative | 0.0122 | 0.0503 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0257 | 0.1158 | 0.285 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0075 | 0.0271 | 0.04 |
Onchocerca volvulus | 0.0971 | 0.463 | 1 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0055 | 0.0413 |
Schistosoma mansoni | amine oxidase | 0.0041 | 0.0106 | 0.0106 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0075 | 0.0271 | 0.0271 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.0197 | 0.0197 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0047 | 0.0135 | 0.0135 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0075 | 0.0271 | 0.085 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0.0106 | 0.1177 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0106 | 0.0252 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0192 | 0.084 | 0.084 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0075 | 0.0271 | 0.0661 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0595 | 0.146 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.0197 | 0.3203 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0295 | 0.1341 | 1 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0047 | 0.0135 | 0.0135 |
Brugia malayi | PHD-finger family protein | 0.0028 | 0.0042 | 0.0097 |
Brugia malayi | hypothetical protein | 0.0229 | 0.1021 | 0.2512 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0075 | 0.0271 | 0.085 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0257 | 0.1158 | 0.2851 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0047 | 0.0135 | 0.0135 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0081 | 0.0304 | 0.0742 |
Brugia malayi | Bromodomain containing protein | 0.0083 | 0.0312 | 0.0763 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0037 | 0.0089 | 0.0089 |
Mycobacterium leprae | conserved hypothetical protein | 0.0075 | 0.0271 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0197 | 0.1876 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0037 | 0.0089 | 0.5 |
Loa Loa (eye worm) | MBCTL1 | 0.0053 | 0.0167 | 0.0403 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0075 | 0.0271 | 0.3169 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.0476 | 0.1167 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0041 | 0.0106 | 0.0395 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0346 | 0.1591 | 0.1591 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0075 | 0.0271 | 0.0271 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0041 | 0.011 | 0.0427 |
Echinococcus multilocularis | geminin | 0.034 | 0.1559 | 0.1559 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.0197 | 0.0197 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0037 | 0.0089 | 0.0089 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0346 | 0.1591 | 0.1591 |
Onchocerca volvulus | 0.0122 | 0.0503 | 0.0985 | |
Schistosoma mansoni | hypothetical protein | 0.034 | 0.1559 | 0.1559 |
Echinococcus granulosus | neuropeptide s receptor | 0.045 | 0.2096 | 0.2096 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0346 | 0.1591 | 0.3917 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0135 | 0.0135 |
Onchocerca volvulus | 0.0075 | 0.0271 | 0.0477 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0075 | 0.0271 | 0.04 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0118 | 0.0481 | 0.0481 |
Echinococcus granulosus | zinc finger protein | 0.0022 | 0.0014 | 0.0014 |
Brugia malayi | SWIRM domain containing protein | 0.0041 | 0.0106 | 0.0254 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0066 | 0.023 | 0.023 |
Mycobacterium ulcerans | hypothetical protein | 0.0155 | 0.0663 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0037 | 0.0089 | 0.0269 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.045 | 0.2096 | 0.2096 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0075 | 0.0271 | 0.04 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0075 | 0.0271 | 0.085 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0295 | 0.1341 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0055 | 0.0413 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.003 | 0.003 |
Mycobacterium ulcerans | monoamine oxidase | 0.0041 | 0.0106 | 0.0283 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0141 | 0.0595 | 0.0595 |
Mycobacterium tuberculosis | Conserved protein | 0.0075 | 0.0271 | 0.085 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0135 | 0.0327 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0155 | 0.0663 | 0.2683 |
Echinococcus multilocularis | 0.0041 | 0.0106 | 0.0106 | |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0041 | 0.0106 | 0.0106 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0156 | 0.0376 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0135 | 0.0135 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0041 | 0.0109 | 0.0109 |
Echinococcus granulosus | peregrin | 0.0032 | 0.0065 | 0.0065 |
Brugia malayi | Bromodomain containing protein | 0.0032 | 0.0065 | 0.0154 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0041 | 0.0106 | 0.0283 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0038 | 0.0093 | 0.0093 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0346 | 0.1591 | 0.1591 |
Mycobacterium tuberculosis | Conserved protein | 0.0075 | 0.0271 | 0.085 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0106 | 0.0252 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0047 | 0.0135 | 0.0135 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0041 | 0.0106 | 0.0106 |
Onchocerca volvulus | 0.0075 | 0.0271 | 0.0477 | |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0106 | 0.0252 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0041 | 0.0106 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0255 | 0.1147 | 0.1147 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0047 | 0.0135 | 0.0326 |
Echinococcus multilocularis | pol protein | 0.0634 | 0.2992 | 0.2992 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0055 | 0.0127 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.0102 | 0.0102 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0036 | 0.0083 | 0.0083 |
Brugia malayi | beta-lactamase family protein | 0.0075 | 0.0271 | 0.0662 |
Brugia malayi | mbt repeat family protein | 0.0047 | 0.0135 | 0.0327 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.2076 | 1 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0019 | 0.0039 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.005 | 0.0154 | 0.0769 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0055 | 0.0049 |
Schistosoma mansoni | hypothetical protein | 0.034 | 0.1559 | 0.1559 |
Onchocerca volvulus | 0.0047 | 0.0135 | 0.0181 | |
Echinococcus multilocularis | pol protein | 0.0634 | 0.2992 | 0.2992 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.003 | 0.0053 | 0.0053 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0075 | 0.0271 | 0.0271 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0141 | 0.0595 | 0.0595 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0053 | 0.0167 | 0.0167 |
Onchocerca volvulus | 0.0075 | 0.0271 | 0.0477 | |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0075 | 0.0271 | 0.085 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0041 | 0.0106 | 0.0254 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0197 | 0.1876 |
Echinococcus multilocularis | pol protein | 0.0634 | 0.2992 | 0.2992 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0197 | 0.0197 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0115 | 0.0275 |
Mycobacterium tuberculosis | Conserved protein | 0.0075 | 0.0271 | 0.085 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0255 | 0.1147 | 0.1147 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0229 | 0.1021 | 0.1021 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.2002 | 0.493 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0271 | 0.0661 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0041 | 0.0106 | 0.0283 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0061 | 0.0206 | 0.0501 |
Onchocerca volvulus | 0.0048 | 0.0141 | 0.0193 | |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0053 | 0.0167 | 0.0167 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0075 | 0.0271 | 0.1682 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0176 | 0.0763 | 0.1875 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.0763 | 0.1874 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.0114 | 0.0275 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0075 | 0.0271 | 0.085 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Decrease (functional) | = 18 % | In vivo evaluation for the percentage decrease in blood pressure at 135 micromol/kg administered through oral route in spontaneously hypertensive rats and observed for 12-18 h. | ChEMBL. | 1542102 |
Decrease (functional) | = 20 % | In vivo evaluation for the percentage decrease in blood pressure at 135 micromol/kg administered through oral route in spontaneously hypertensive rats and observed for 0-6 h. | ChEMBL. | 1542102 |
Decrease (functional) | = 21 % | In vivo evaluation for the percentage decrease in blood pressure at 135 micromol/kg administered through oral route in spontaneously hypertensive rats and observed for 6-12 h. | ChEMBL. | 1542102 |
Decrease (functional) | = 29 % | In vivo evaluation for the percentage decrease in blood pressure at 135 micromol/kg administered through oral route in spontaneously hypertensive rats and observed for 6-12 h. | ChEMBL. | 1542102 |
Decrease (functional) | = 29 % | In vivo evaluation for the percentage decrease in blood pressure at 135 micromol/kg administered through oral route in spontaneously hypertensive rats and observed for 12-18 h. | ChEMBL. | 1542102 |
Decrease (functional) | = 30 % | In vivo evaluation for the percentage decrease in blood pressure at 135 micromol/kg administered through oral route in spontaneously hypertensive rats and observed for 0-6 h. | ChEMBL. | 1542102 |
IC50 (functional) | = 0.52 uM | In vitro evaluation of the compound for the vasorelaxant effects in circumferential strips of potassium-depolarized rabbit aorta. (IC50 in rabbit aorta strips contracted with KCl | ChEMBL. | 1542102 |
IC50 (functional) | = 1.1 uM | Vasorelaxant effects in circumferential strips of potassium-depolarized rabbit aorta. (IC50 in rabbit aorta strips contracted with KCl(95% confidence interval)) | ChEMBL. | 1542102 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.