Detailed information for compound 289100

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 433.168 | Formula: C18H9Cl2F2N2NaO3
  • H donors: 2 H acceptors: 3 LogP: 5.27 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1F)F)/C=C/c1c([nH]c2c1c(Cl)cc(c2)Cl)C(=O)[O-].[Na+]
  • InChi: 1S/C18H10Cl2F2N2O3.Na/c19-8-5-11(20)16-10(17(18(26)27)24-14(16)6-8)2-4-15(25)23-13-3-1-9(21)7-12(13)22;/h1-7,24H,(H,23,25)(H,26,27);/q;+1/p-1/b4-2+;
  • InChiKey: DOPFLZCFNTZQLR-VEELZWTKSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum expressed protein Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus multilocularis glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus multilocularis nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma mansoni glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus multilocularis nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Drosophila melanogaster NMDA receptor 2 Glutamate (NMDA) receptor subunit zeta 1   938 aa 878 aa 27.4 %
Echinococcus multilocularis glutamate (NMDA) receptor subunit Glutamate (NMDA) receptor subunit zeta 1   938 aa 822 aa 23.2 %
Drosophila melanogaster Glutamate receptor IA Glutamate (NMDA) receptor subunit zeta 1   938 aa 979 aa 23.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0061 0.0523
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0024 0.0018 0.0148
Schistosoma mansoni tyrosine kinase 0.0313 0.1069 0.1933
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0025 0.0217
Loa Loa (eye worm) hypothetical protein 0.0073 0.0195 0.0465
Trypanosoma cruzi aurora B kinase, putative 0.0126 0.0389 0.3455
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0001 0.0001
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0009 0.0015
Loa Loa (eye worm) hypothetical protein 0.0051 0.0115 0.0275
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0068 0.0178 0.1573
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0025 0.0023 0.0041
Schistosoma mansoni hypothetical protein 0.0319 0.1091 0.1973
Echinococcus multilocularis tyrosine protein kinase Blk 0.0049 0.0111 0.02
Echinococcus granulosus tyrosine protein kinase HCK 0.0045 0.0097 0.0173
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0009 0.0009
Trypanosoma brucei RNA helicase, putative 0.0914 0.3249 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0022
Brugia malayi Trypsin family protein 0.0034 0.0057 0.0057
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0006 0.0006
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0001 0.0001
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0192 0.1758
Echinococcus granulosus tyrosine protein kinase Fyn 0.0053 0.0126 0.0226
Onchocerca volvulus 0.0021 0.0009 0.0074
Schistosoma mansoni tyrosine kinase 0.0287 0.0975 0.1762
Echinococcus granulosus casein kinase ii subunit alpha 0.0077 0.0211 0.0381
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0025 0.0041
Brugia malayi Phosphoglycerate kinase 0.0185 0.0603 0.0603
Giardia lamblia Pyruvate kinase 0.0073 0.0195 0.1784
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0019 0.0001 0.0003
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0099 0.087
Echinococcus multilocularis hemicentin 1 0.0019 0.0001 0.0001
Echinococcus multilocularis muscleblind protein 0.0162 0.0521 0.0941
Onchocerca volvulus 0.0034 0.0057 0.0457
Echinococcus multilocularis cyclins 0.0019 0.0002 0.0002
Schistosoma mansoni loxhd1 0.0023 0.0014 0.0025
Mycobacterium tuberculosis Mycobacterial persistence regulator MRPA (two component response transcriptional regulatory protein) 0.0024 0.0018 0.0029
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0024 0.0372
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0006 0.0008
Treponema pallidum fructose-bisphosphate aldolase 0.0318 0.1085 1
Brugia malayi protein unc-22 0.0019 0.0001 0.0001
Entamoeba histolytica protein kinase, putative 0.004 0.0078 0.0704
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0009 0.0009
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0001 0.0001
Brugia malayi Doublecortin family protein 0.0023 0.0014 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0009 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0009 0.0009
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0192 0.1698
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0159 0.0508 0.4508
Echinococcus multilocularis pyruvate kinase 0.0037 0.0067 0.012
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0034 0.0057 0.0101
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0022
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0155 0.0496 0.1522
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0024 0.0167
Entamoeba histolytica casein kinase, putative 0.0077 0.0211 0.1934
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0006 0.0014
Schistosoma mansoni cyclin B3 0.0019 0.0002 0.0003
Trichomonas vaginalis pyruvate kinase, putative 0.0073 0.0195 0.1784
Loa Loa (eye worm) hypothetical protein 0.0059 0.0147 0.0351
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0025 0.0041
Plasmodium vivax pyruvate kinase 2, putative 0.0037 0.0067 0.1084
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0185 0.0603 0.5363
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.003 0.004 0.0094
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0003
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0035 0.0302
Echinococcus multilocularis lachesin 0.0019 0.0001 0.0001
Treponema pallidum chemotaxis response regulator (cheY) 0.0024 0.0018 0.011
Echinococcus granulosus tyrosine protein kinase Src42A 0.0053 0.0126 0.0226
Brugia malayi Pyruvate kinase, M2 isozyme 0.0073 0.0195 0.0195
Leishmania major pyruvate kinase 0.0073 0.0195 0.1723
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0328 0.1124 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0003
Echinococcus granulosus serine threonine protein kinase nrc 0.0027 0.0029 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0084 0.0253
Toxoplasma gondii pyruvate kinase PyK1 0.0073 0.0195 0.3165
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.0211 0.1934
Trypanosoma cruzi casein kinase II, putative 0.0077 0.0211 0.1868
Mycobacterium tuberculosis Possible hydrolase 0.0083 0.0232 0.0417
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0051 0.0116 0.102
Trypanosoma cruzi polo-like protein kinase, putative 0.0159 0.0508 0.4508
Echinococcus multilocularis phosphoglycerate kinase 1 0.0185 0.0603 0.109
Loa Loa (eye worm) hypothetical protein 0.007 0.0185 0.044
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0126 0.0389 0.0703
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0057 0.0102
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0057 0.0102
Loa Loa (eye worm) pyruvate kinase-PB 0.0051 0.0115 0.0275
Entamoeba histolytica N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative 0.0053 0.0123 0.1119
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0053 0.0123 0.1119
Echinococcus multilocularis 0.0138 0.0431 0.0778
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0192 0.1698
Echinococcus granulosus tyrosine protein kinase Fyn 0.0053 0.0126 0.0226
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Schistosoma mansoni N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 0.0053 0.0123 0.0223
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0057 0.0102
Echinococcus granulosus cyclins 0.0019 0.0002 0.0002
Schistosoma mansoni cyclins 0.0019 0.0002 0.0003
Schistosoma mansoni cell adhesion molecule 0.0025 0.0023 0.0042
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0057 0.0101
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0025 0.021
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0025 0.0023 0.0042
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0084 0.0253
Schistosoma mansoni tyrosine kinase 0.03 0.1019 0.1843
Trypanosoma brucei phosphoglycerate kinase 0.0068 0.0178 0.0544
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0003
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0053 0.0126 0.0226
Echinococcus granulosus roundabout 2 0.0062 0.0158 0.0285
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0037 0.0108
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0033
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0023 0.0015 0.0024
Brugia malayi Immunoglobulin I-set domain containing protein 0.0399 0.138 0.138
Trypanosoma brucei DNA polymerase eta, putative 0.007 0.0185 0.0563
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0025 0.0041
Loa Loa (eye worm) hypothetical protein 0.0026 0.0025 0.0061
Loa Loa (eye worm) hypothetical protein 0.0052 0.012 0.0286
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0006 0.0008
Mycobacterium tuberculosis Two component sensory transduction protein RegX3 (transcriptional regulatory protein) (probably LuxR-family) 0.0024 0.0018 0.0029
Echinococcus granulosus epidermal growth factor receptor 0.0313 0.1069 0.1932
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0024 0.0372
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0068 0.0178 0.1573
Echinococcus granulosus muscleblind protein 0.0162 0.0521 0.0941
Schistosoma mansoni nephrin 0.0052 0.0119 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0009 0.0009
Echinococcus granulosus expressed protein 0.0036 0.0064 0.0114
Brugia malayi SRC-1 0.0053 0.0126 0.0126
Loa Loa (eye worm) pyruvate kinase 0.0073 0.0195 0.0465
Giardia lamblia DINP protein human, muc B family 0.0042 0.0084 0.076
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0014 0.0033
Loa Loa (eye worm) hypothetical protein 0.0034 0.0057 0.0135
Trichomonas vaginalis pyruvate kinase, putative 0.0073 0.0195 0.1784
Mycobacterium leprae Probable pyruvate kinase PykA 0.0073 0.0195 0.031
Brugia malayi serine/threonine protein kinase 6 0.0126 0.0389 0.0389
Mycobacterium tuberculosis Possible two component system response transcriptional positive regulator PhoP 0.0024 0.0018 0.0029
Echinococcus granulosus pyruvate kinase 0.0073 0.0195 0.0352
Trichomonas vaginalis CAMK family protein kinase 0.0159 0.0508 0.4668
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0014 0.0024
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0009 0.0015
Plasmodium falciparum phosphoglycerate kinase 0.0185 0.0603 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0061 0.0181
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0125 0.0387 0.0698
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0185 0.0603 1
Onchocerca volvulus 0.0034 0.0057 0.0457
Mycobacterium tuberculosis Probable two component transcriptional regulatory protein TcrX 0.0024 0.0018 0.0029
Trichomonas vaginalis rotamase, putative 0.0035 0.0061 0.0542
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0025 0.021
Entamoeba histolytica cell division protein kinase 2, putative 0.0051 0.0116 0.1057
Entamoeba histolytica protein kinase , putative 0.0126 0.0389 0.3578
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0014 0.0024
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0027 0.0029 0.0449
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.0211 0.1934
Mycobacterium ulcerans two component transcriptional regulator 0.0024 0.0018 0.0028
Echinococcus granulosus defective proboscis extension response 0.0037 0.0066 0.0119
Loa Loa (eye worm) hypothetical protein 0.1174 0.4194 1
Brugia malayi Trypsin family protein 0.0034 0.0057 0.0057
Schistosoma mansoni rotamase 0.0036 0.0064 0.0115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0009 0.0022
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0035 0.0302
Echinococcus multilocularis pyruvate kinase 0.0073 0.0195 0.0352
Echinococcus multilocularis Immunoglobulin 0.0037 0.0066 0.0119
Echinococcus multilocularis nmda type glutamate receptor 0.01 0.0294 0.0531
Wolbachia endosymbiont of Brugia malayi response regulator PleD 0.0024 0.0018 0.0198
Trypanosoma brucei Casein kinase II 0.0077 0.0211 0.0645
Trypanosoma cruzi cdc2-related kinase 1 0.0051 0.0116 0.102
Brugia malayi hypothetical protein 0.0023 0.0014 0.0014
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0192 0.0347
Echinococcus granulosus dna polymerase eta 0.007 0.0185 0.0333
Echinococcus multilocularis pyruvate kinase 0.0037 0.0067 0.012
Loa Loa (eye worm) hypothetical protein 0.0034 0.0057 0.0135
Schistosoma mansoni tyrosine kinase 0.0033 0.0051 0.0092
Mycobacterium ulcerans N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB 0.0053 0.0123 0.0212
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0084 0.0734
Trichomonas vaginalis AGC family protein kinase 0.004 0.0078 0.0704
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Onchocerca volvulus 0.0338 0.1157 0.9353
Trichomonas vaginalis receptor histidine kinase, putative 0.0024 0.0018 0.0148
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0009 0.0015
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.0496 0.4404
Giardia lamblia Kinase, CMGC CK2 0.0077 0.0211 0.1934
Entamoeba histolytica pyruvate kinase, putative 0.0051 0.0115 0.1048
Schistosoma mansoni tyrosine kinase 0.0053 0.0126 0.0228
Schistosoma mansoni titin 0.0019 0.0001 0.0002
Brugia malayi steroid hormone receptor 0.0021 0.0009 0.0009
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0037 0.0066 0.0119
Plasmodium falciparum casein kinase 2, alpha subunit 0.0077 0.0211 0.3484
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0051 0.0116 0.102
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0023 0.0015 0.0225
Mycobacterium tuberculosis Probable sulfatase 0.0083 0.0232 0.0417
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0019 0.0002 0.0002
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0083 0.0232 0.0417
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0185 0.0603 0.5363
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0009 0.0016
Giardia lamblia Pyruvate kinase 0.0037 0.0067 0.0601
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0009 0.0016
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0053 0.0126 0.0226
Loa Loa (eye worm) phosphatidylinositol glycan anchor biosynthesis protein 0.0053 0.0123 0.0294
Loa Loa (eye worm) hypothetical protein 0.0037 0.0066 0.0158
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0025 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0009 0.0009
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.0083 0.0232 0.2128
Echinococcus granulosus tyrosine protein kinase Src64B 0.0053 0.0126 0.0226
Echinococcus granulosus phosphoglycerate kinase 1 0.0185 0.0603 0.109
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0024 0.0302
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0025 0.0025
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0009 0.0016
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0061 0.0542
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0023 0.0015 0.0086
Trichomonas vaginalis rotamase, putative 0.0036 0.0064 0.057
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0084 0.0253
Echinococcus granulosus serine/threonine protein kinase 0.0029 0.0037 0.0065
Echinococcus multilocularis cyclin dependent kinase 1 0.0051 0.0116 0.0209
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0208 0.0689 0.1244
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0159 0.0508 0.0917
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0068 0.0178 0.1573
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0146 0.0264
Loa Loa (eye worm) TK/EGFR protein kinase 0.0463 0.1613 0.3847
Brugia malayi hypothetical protein 0.0034 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0034 0.0056 0.0133
Echinococcus multilocularis transmembrane protease serine 3 0.0034 0.0057 0.0101
Mycobacterium tuberculosis Conserved hypothetical protein 0.0173 0.056 0.1008
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0006 0.0039
Loa Loa (eye worm) hypothetical protein 0.0083 0.0232 0.0554
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0006 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0004
Echinococcus multilocularis epidermal growth factor receptor 0.0313 0.1069 0.1932
Brugia malayi cell division control protein 2 homolog 0.0051 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0026 0.0025 0.0061
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0084 0.076
Schistosoma mansoni tyrosine kinase 0.0398 0.1376 0.2488
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0057 0.0102
Treponema pallidum protein-glutamate methylesterase (cheB) 0.0024 0.0018 0.011
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0009 0.0015
Trichomonas vaginalis AGC family protein kinase 0.0126 0.0389 0.3578
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0025 0.0217
Mycobacterium tuberculosis Possible nitrate/nitrite response transcriptional regulatory protein NarL 0.0024 0.0018 0.0029
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0051 0.0116 0.0277
Echinococcus multilocularis cyclins 0.0019 0.0002 0.0002
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0034 0.0057 0.0101
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0083 0.0232 0.0417
Chlamydia trachomatis glutamine binding protein 0.0023 0.0015 0.0225
Schistosoma mansoni tyrosine kinase 0.0053 0.0126 0.0228
Loa Loa (eye worm) hypothetical protein 0.0059 0.0146 0.0348
Loa Loa (eye worm) pyruvate kinase 0.0073 0.0195 0.0465
Echinococcus granulosus L aminoadipate semialdehyde 0.009 0.026 0.0469
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0084 0.0253
Mycobacterium ulcerans glutaminase 0.0297 0.1011 0.1762
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Loa Loa (eye worm) glutaminase 0.0297 0.1011 0.241
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0318 0.1085 1
Onchocerca volvulus 0.0034 0.0057 0.0457
Echinococcus multilocularis enteropeptidase 0.0034 0.0057 0.0101
Echinococcus multilocularis neuroglian 0.0025 0.0023 0.0041
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0061 0.0523
Toxoplasma gondii hypothetical protein 0.0053 0.0124 0.1975
Echinococcus granulosus cyclin dependent kinase 5 0.0051 0.0116 0.0209
Echinococcus multilocularis pyruvate kinase 0.0057 0.014 0.0251
Echinococcus multilocularis tyrosine protein kinase HCK 0.0045 0.0097 0.0173
Treponema pallidum phosphoglycerate kinase 0.0185 0.0603 0.5536
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0035 0.0083
Echinococcus granulosus protein tyrosine kinase 0.0287 0.0975 0.1761
Loa Loa (eye worm) glutaminase 2 0.0297 0.1011 0.241
Mycobacterium ulcerans pyruvate kinase 0.0073 0.0195 0.0338
Echinococcus granulosus cyclin b3 0.0019 0.0002 0.0002
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0126 0.0389 0.6443
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0084 0.0144
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0022 0.0012 0.0012
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0003
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0009 0.0015
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0185 0.0603 0.1087
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0328 0.1124 1
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0057 0.0102
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0009 0.0016
Echinococcus multilocularis Immunoglobulin 0.0037 0.0066 0.0119
Brugia malayi protein-tyrosine kinase 0.0049 0.0111 0.0111
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.0211 0.1934
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0024 0.0018 0.0148
Schistosoma mansoni coup transcription factor 0.0021 0.0009 0.0016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0033
Echinococcus granulosus insulin receptor 0.0398 0.1376 0.2487
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0116 0.021
Onchocerca volvulus 0.0019 0.0002 0.0015
Brugia malayi serine/threonine kinase 12 0.0126 0.0389 0.0389
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0064 0.0152
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0057 0.0102
Plasmodium falciparum cyclin 0.0019 0.0002 0.0002
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0009 0.0015
Echinococcus granulosus cyclin B 0.0019 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0009 0.0009
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0024 0.004
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0051 0.0116 0.0277
Echinococcus multilocularis microtubule associated protein 2 0.1542 0.5531 1
Echinococcus granulosus neuroglian 0.0025 0.0023 0.0041
Echinococcus granulosus microtubule associated protein 2 0.1542 0.5531 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0399 0.138 0.3291
Echinococcus granulosus nmda type glutamate receptor 0.0127 0.0394 0.0711
Trichomonas vaginalis CAMK family protein kinase 0.0159 0.0508 0.4668
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0004
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0009 0.0015
Echinococcus multilocularis cyclin B3 1 0.0019 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0022
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0019 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0022 0.0011 0.0018
Toxoplasma gondii AGC kinase 0.0038 0.007 0.1071
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0035 0.0101
Brugia malayi Casein kinase II, alpha chain 0.0077 0.0211 0.0211
Mycobacterium ulcerans two component system response phosphate regulon transcriptional regulator, PhoP 0.0024 0.0018 0.0028
Trypanosoma cruzi cdc2-related kinase 3 0.0051 0.0116 0.102
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0004
Echinococcus granulosus cyclins 0.0019 0.0002 0.0002
Echinococcus multilocularis nervana 2 0.0022 0.0013 0.0022
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0009 0.0015
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0025 0.0041
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0155 0.0495 0.0892
Brugia malayi Trypsin family protein 0.0034 0.0057 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0159 0.0508 0.4668
Trypanosoma brucei cdc2-related kinase 3 0.0051 0.0116 0.0353
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0009 0.0022
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0009 0.0015
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0063 0.0162 0.0292
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0009 0.0016
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0126 0.0389 0.3578
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0014 0.0024
Echinococcus granulosus c src tyrosine kinase 0.0022 0.0011 0.0018
Echinococcus granulosus enteropeptidase 0.0034 0.0057 0.0101
Mycobacterium tuberculosis Conserved hypothetical protein 0.0053 0.0123 0.0219
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0077 0.0211 0.0504
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0155 0.0495 0.0836
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0037 0.0108
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0019 0.0001 0.0003
Onchocerca volvulus 0.0019 0.0001 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0084 0.0253
Brugia malayi Pyruvate kinase, muscle isozyme 0.0073 0.0195 0.0195
Entamoeba histolytica protein kinase, putative 0.0045 0.0097 0.0874
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0014 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0084 0.0253
Mycobacterium tuberculosis Two component DNA binding transcriptional regulatory protein TcrA 0.0024 0.0018 0.0029
Loa Loa (eye worm) hypothetical protein 0.0162 0.0521 0.1243
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0192 0.0459
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0185 0.0603 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0066 0.0158
Echinococcus granulosus peroxidasin 0.0019 0.0001 0.0001
Brugia malayi ImpB/MucB/SamB family protein 0.007 0.0185 0.0185
Schistosoma mansoni protein kinase 0.0077 0.0211 0.0382
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0024 0.0039
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0035 0.0478
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Mycobacterium ulcerans two component sensory transduction transcriptional regulatory protein MtrA 0.0024 0.0018 0.0028
Loa Loa (eye worm) hypothetical protein 0.0185 0.0603 0.1439
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0404 0.1398 0.2527
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0084 0.0734
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0025 0.0043
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0009 0.0015
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0009 0.0016
Echinococcus granulosus tyrosine protein kinase Blk 0.0049 0.0111 0.02
Trypanosoma brucei phosphoglycerate kinase, putative 0.0068 0.0178 0.0544
Loa Loa (eye worm) hypothetical protein 0.0083 0.0232 0.0554
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0057 0.0102
Echinococcus granulosus pyruvate kinase 0.0037 0.0067 0.012
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0057 0.0102
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0146 0.0263
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0006 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Plasmodium vivax N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0053 0.0123 0.2017
Plasmodium vivax protein kinase Crk2 0.0051 0.0116 0.1904
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0192 0.0192
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0084 0.0253
Brugia malayi serine/threonine-protein kinase 6 0.0126 0.0389 0.0389
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0057 0.0102
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.0084 0.0734
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0034 0.0057 0.0102
Echinococcus multilocularis roundabout 2 0.0025 0.0023 0.0041
Echinococcus granulosus hemicentin 1 0.0019 0.0001 0.0001
Echinococcus granulosus N acetylglucosaminyl phosphatidylinositol 0.0053 0.0123 0.0221
Brugia malayi Tyrosine-protein kinase abl-1 0.0022 0.0011 0.0011
Giardia lamblia Hypothetical protein 0.0083 0.0232 0.2128
Loa Loa (eye worm) AUR protein kinase 0.0126 0.0389 0.0929
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0025 0.0023 0.0056
Loa Loa (eye worm) hypothetical protein 0.0026 0.0025 0.0061
Brugia malayi plexin A 0.0022 0.0012 0.0012
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0146 0.0263
Schistosoma mansoni pyruvate kinase 0.0073 0.0195 0.0353
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0083 0.0148
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0024 0.0039
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0051 0.0116 0.1846
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0001 0.0001
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0053 0.0126 0.0226
Leishmania major DNA polymerase kappa, putative 0.0042 0.0084 0.0734
Leishmania major DNA polymerase eta, putative 0.007 0.0185 0.163
Entamoeba histolytica serine/threonine protein kinase, putative 0.0159 0.0508 0.4668
Trypanosoma brucei cdc2-related kinase 1 0.0051 0.0116 0.0353
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0077 0.0211 0.3484
Onchocerca volvulus Serine\/threonine kinase homolog 0.0159 0.0508 0.4103
Loa Loa (eye worm) TK/INSR protein kinase 0.0398 0.1376 0.3281
Onchocerca volvulus 0.0023 0.0014 0.0113
Onchocerca volvulus Tyrosine kinase homolog 0.036 0.1237 1
Brugia malayi mbt repeat family protein 0.0052 0.012 0.012
Toxoplasma gondii CMGC kinase, CK2 family 0.0077 0.0211 0.3437
Onchocerca volvulus 0.0034 0.0057 0.0457
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.0083 0.0232 0.2128
Brugia malayi p70 ribosomal S6 kinase beta 0.0038 0.007 0.007
Leishmania major phosphoglycerate kinase B, cytosolic 0.0185 0.0603 0.5363
Echinococcus multilocularis cyclin dependent kinase 5 0.0051 0.0116 0.0209
Chlamydia trachomatis pyruvate kinase 0.0073 0.0195 0.3214
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0192 0.0347
Mycobacterium ulcerans two component response transcriptional regulatory protein MprA 0.0024 0.0018 0.0028
Giardia lamblia Glucosamine-6-phosphate isomerase, putative 0.0053 0.0123 0.1119
Brugia malayi Immunoglobulin I-set domain containing protein 0.0022 0.0012 0.0012
Schistosoma mansoni cell adhesion molecule 0.0019 0.0001 0.0002
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0057 0.0102
Schistosoma mansoni ephrin receptor 0.002 0.0004 0.0007
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0025 0.0217
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0032 0.0048 0.0085
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0159 0.0508 0.121
Treponema pallidum response regulatory protein (atoC) 0.0024 0.0018 0.011
Schistosoma mansoni phosphoglycerate kinase 0.0185 0.0603 0.1091
Trichomonas vaginalis AGC family protein kinase 0.004 0.0078 0.0704
Brugia malayi Fibronectin type III domain containing protein 0.0043 0.0089 0.0089
Giardia lamblia Kinase, CMGC CDK 0.0051 0.0116 0.1057
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0006 0.001
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0027 0.0029 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0009 0.0009
Echinococcus multilocularis roundabout 2 0.0062 0.0158 0.0285
Brugia malayi Protein kinase domain containing protein 0.0169 0.0545 0.0545
Echinococcus multilocularis c src tyrosine kinase 0.0022 0.0011 0.0018
Onchocerca volvulus Pyruvate kinase homolog 0.0073 0.0195 0.1577
Schistosoma mansoni ephrin receptor 0.0073 0.0197 0.0356
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0009 0.0009
Trypanosoma cruzi cdc2-related kinase 1 0.0051 0.0116 0.102
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0159 0.0508 0.0917
Schistosoma mansoni phosphoglycerate kinase 0.0185 0.0603 0.1091
Mycobacterium ulcerans two component transcriptional regulator 0.0024 0.0018 0.0028
Echinococcus multilocularis insulin receptor 0.0398 0.1376 0.2487
Schistosoma mansoni ap endonuclease 0.002 0.0006 0.0011
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0318 0.1085 1
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0037 0.0066 0.012
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.012 0.0971
Brugia malayi Phosphoglycerate kinase 0.0068 0.0178 0.0178
Schistosoma mansoni microtubule-associated protein tau 0.1542 0.5531 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0009 0.0015
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0024 0.0018 0.0148
Echinococcus multilocularis neuroglian 0.0045 0.0097 0.0174
Brugia malayi Cyclin, N-terminal domain containing protein 0.0019 0.0002 0.0002
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0025 0.0023 0.0041
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0035 0.0546
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0009 0.0022
Echinococcus multilocularis cyclin B 0.0019 0.0002 0.0002
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0024 0.0011
Mycobacterium tuberculosis N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) 0.0053 0.0123 0.0219
Giardia lamblia Kinase, PLK 0.0159 0.0508 0.4668
Entamoeba histolytica protein kinase, putative 0.0126 0.0389 0.3578
Schistosoma mansoni serine/threonine-protein kinase 0.0029 0.0037 0.0067
Schistosoma mansoni tyrosine kinase 0.0398 0.1376 0.2488
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0024 0.0018 0.0198
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0053 0.0123 0.1119
Plasmodium falciparum N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0053 0.0123 0.2017
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0068 0.0178 0.1573
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0084 0.0734
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0083 0.0148
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0061 0.0912
Schistosoma mansoni vesicular amine transporter 0.0037 0.0066 0.012
Mycobacterium ulcerans two component response transcriptional regulatory protein PrrA 0.0024 0.0018 0.0028
Schistosoma mansoni tyrosine kinase 0.0463 0.1613 0.2917
Trypanosoma brucei phosphoglycerate kinase 0.0185 0.0603 0.1853
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0025 0.0013
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0035 0.0292
Schistosoma mansoni rab6-interacting 0.0023 0.0014 0.0025
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0024 0.0302
Echinococcus multilocularis ephrin type A receptor 4 A 0.0087 0.0248 0.0447
Schistosoma mansoni pyruvate kinase 0.0037 0.0067 0.0121
Entamoeba histolytica PH domain containing protein kinase, putative 0.0029 0.0037 0.0323
Brugia malayi nuclear receptor NHR-88 0.0021 0.0009 0.0009
Wolbachia endosymbiont of Brugia malayi response regulator 0.0024 0.0018 0.0198
Trichomonas vaginalis AGC family protein kinase 0.004 0.0078 0.0704
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0023 0.0023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.1085 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0022 0.0011 0.002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.1085 1
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Mycobacterium tuberculosis Two component transcriptional regulator TrcR 0.0024 0.0018 0.0029
Entamoeba histolytica PH domain containing protein kinase, putative 0.0029 0.0037 0.0323
Brugia malayi Cyclin, N-terminal domain containing protein 0.0019 0.0002 0.0002
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.0211 0.1934
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0053 0.0126 0.0226
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.012 0.0217
Mycobacterium ulcerans mycothiol conjugate amidase Mca 0.1597 0.5729 1
Loa Loa (eye worm) AGC/AKT protein kinase 0.004 0.0078 0.0186
Echinococcus granulosus Glutaredoxin protein 5 0.0022 0.0013 0.0022
Brugia malayi Protein kinase domain containing protein 0.004 0.0078 0.0078
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0099 0.03
Loa Loa (eye worm) hypothetical protein 0.0037 0.0066 0.0158
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0009 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0084 0.0253
Schistosoma mansoni septate junction protein 0.0019 0.0001 0.0002
Brugia malayi serine/threonine-protein kinase plk-2 0.0159 0.0508 0.0508
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0009 0.0022
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0053 0.0126 0.0226
Echinococcus granulosus dna polymerase kappa 0.0042 0.0084 0.0151
Mycobacterium ulcerans nitrate/nitrite response regulator protein NarL 0.0024 0.0018 0.0028
Echinococcus granulosus transmembrane protease serine 3 0.0034 0.0057 0.0101
Giardia lamblia Fructose-bisphosphate aldolase 0.0318 0.1085 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0009 0.0074
Loa Loa (eye worm) SRC-1 0.0053 0.0126 0.03
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0155 0.0495 0.0862
Echinococcus granulosus roundabout 2 0.0025 0.0023 0.0041
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0009 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0009 0.0022
Schistosoma mansoni neuroglian 0.0025 0.0023 0.0042
Mycobacterium ulcerans two-component system transcriptional regulator 0.0024 0.0018 0.0028
Mycobacterium tuberculosis Two component sensory transduction transcriptional regulatory protein MtrA 0.0024 0.0018 0.0029
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0084 0.0144
Echinococcus granulosus nmda type glutamate receptor 0.01 0.0294 0.0531
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.0211 0.1934
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0037 0.0066 0.012
Loa Loa (eye worm) hypothetical protein 0.0034 0.0057 0.0135
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0006 0.0072
Trypanosoma brucei unspecified product 0.0029 0.0037 0.0108
Schistosoma mansoni sex comb on midleg homolog 0.0057 0.0137 0.0248
Echinococcus multilocularis glutamate receptor NMDA 0.0095 0.0278 0.0501
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0038 0.007 0.0167
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0025 0.0025
Echinococcus granulosus glutamate receptor NMDA 0.0095 0.0278 0.0501
Echinococcus granulosus aurora kinase A 0.0126 0.0389 0.0703
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0136 0.1196
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0063 0.0162 0.0292
Brugia malayi glutaminase DH11.1 0.0297 0.1011 0.1011
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0023 0.0023
Echinococcus multilocularis dna polymerase eta 0.007 0.0185 0.0333
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0024 0.0018 0.0148
Loa Loa (eye worm) hypothetical protein 0.0043 0.0089 0.0212
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0053 0.0126 0.0226
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0014 0.0204
Entamoeba histolytica deoxycytidyl transferase, putative 0.0042 0.0084 0.076
Trichomonas vaginalis CAMK family protein kinase 0.0159 0.0508 0.4668
Schistosoma mansoni tyrosine kinase 0.03 0.1019 0.1843
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0049 0.0111 0.02
Mycobacterium tuberculosis Probable two-component system transcriptional regulator 0.0024 0.0018 0.0029
Onchocerca volvulus 0.0034 0.0057 0.0457
Echinococcus granulosus cyclins 0.0019 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0004
Onchocerca volvulus 0.0034 0.0057 0.0457
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0025 0.0041
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0057 0.0102
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0006 0.0037
Trichomonas vaginalis glutaminase, putative 0.0297 0.1011 0.9311
Onchocerca volvulus 0.0023 0.0014 0.0113
Schistosoma mansoni serine/threonine-protein kinase 0.0029 0.0037 0.0067
Mycobacterium ulcerans two component sensory transduction protein RegX3 0.0024 0.0018 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Trypanosoma brucei phosphoglycerate kinase 0.0185 0.0603 0.1853
Echinococcus multilocularis polycomb protein SCMH1 0.0057 0.0137 0.0246
Schistosoma mansoni pyruvate kinase 0.0073 0.0195 0.0353
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0053 0.0126 0.0226
Schistosoma mansoni glutamate receptor NMDA 0.0109 0.0327 0.0591
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0024 0.0198
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0014 0.0024
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0084 0.076
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0068 0.0178 0.1573
Echinococcus granulosus cyclins 0.0019 0.0002 0.0002
Plasmodium vivax unspecified product 0.0077 0.0211 0.3484
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0042 0.0084 0.0151
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0053 0.0126 0.0226
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0035 0.0061
Schistosoma mansoni sensor histidine kinase/response regulator 0.0024 0.0018 0.0032
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0006 0.001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0009 0.0009
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0057 0.0102
Echinococcus multilocularis tyrosine protein kinase otk 0.0019 0.0001 0.0001
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0024 0.0372
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0146 0.0263
Brugia malayi Muscleblind-like protein 0.0162 0.0521 0.0521
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0125 0.0387 0.0698
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.008 0.0693
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0089 0.0089
Onchocerca volvulus Pyruvate kinase homolog 0.0073 0.0195 0.1577
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0024 0.0018 0.0148
Echinococcus multilocularis glycoprotein Antigen 5 0.0034 0.0057 0.0101
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0073 0.0195 0.0349
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0084 0.0253
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0057 0.0102
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0051 0.0116 0.0277
Plasmodium falciparum serine/threonine protein kinase, putative 0.0126 0.0389 0.6443
Loa Loa (eye worm) trypsin family protein 0.0034 0.0057 0.0135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0009 0.0022
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0025 0.0013
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0057 0.0102
Trypanosoma cruzi DNA polymerase eta, putative 0.007 0.0185 0.163
Leishmania major phosphoglycerate kinase C, glycosomal 0.0185 0.0603 0.5363
Trichomonas vaginalis AGC family protein kinase 0.004 0.0078 0.0704
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Leishmania major DNA polymerase eta, putative 0.0041 0.008 0.0693
Echinococcus multilocularis nervana 2 0.0022 0.0013 0.0022
Echinococcus multilocularis roundabout 2 0.0025 0.0023 0.0041
Echinococcus granulosus cyclin dependent kinase 0.0051 0.0116 0.0209
Brugia malayi Trypsin-like protease protein 5 0.0034 0.0057 0.0057
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.009 0.026 0.026
Echinococcus granulosus RUN 0.0023 0.0014 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0084 0.0253
Loa Loa (eye worm) hypothetical protein 0.0034 0.0057 0.0135
Schistosoma mansoni roundabout 0.0019 0.0001 0.0002
Echinococcus multilocularis cyclin dependent kinase 1 0.0051 0.0116 0.0209
Mycobacterium ulcerans hypothetical protein 0.0173 0.056 0.0974
Schistosoma mansoni hypothetical protein 0.0914 0.3249 0.5874
Brugia malayi Furin-like cysteine rich region family protein 0.0463 0.1613 0.1613
Loa Loa (eye worm) hypothetical protein 0.009 0.026 0.062
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0025 0.0023 0.0041
Plasmodium vivax phosphoglycerate kinase, putative 0.0185 0.0603 1
Mycobacterium leprae Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase) 0.1597 0.5729 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0022
Schistosoma mansoni lipoxygenase 0.0023 0.0014 0.0025
Trypanosoma cruzi cdc2-related kinase 3 0.0051 0.0116 0.102
Brugia malayi ecdysteroid receptor 0.0021 0.0009 0.0009
Echinococcus granulosus plexin a4 0.0022 0.0012 0.0021
Schistosoma mansoni protein kinase 0.0126 0.0389 0.0704
Giardia lamblia Kinase, CMGC CDK 0.0051 0.0116 0.1057
Echinococcus multilocularis Glutaredoxin protein 5 0.0022 0.0013 0.0022
Schistosoma mansoni titin 0.0019 0.0001 0.0001
Trypanosoma brucei unspecified product 0.0042 0.0084 0.0253
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Loa Loa (eye worm) TK protein kinase 0.0045 0.0097 0.023
Loa Loa (eye worm) hypothetical protein 0.0162 0.0521 0.1243
Schistosoma mansoni hypothetical protein 0.0023 0.0014 0.0025
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0022
Loa Loa (eye worm) AUR protein kinase 0.0126 0.0389 0.0929
Entamoeba histolytica protein kinase domain containing protein 0.0126 0.0389 0.3578
Echinococcus multilocularis muscleblind protein 1 0.0162 0.0521 0.0941
Toxoplasma gondii aurora kinase 0.0126 0.0389 0.6418
Trichomonas vaginalis CAMK family protein kinase 0.0159 0.0508 0.4668
Plasmodium vivax pyruvate kinase, putative 0.0073 0.0195 0.3214
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0057 0.0102
Echinococcus multilocularis aurora kinase A 0.0126 0.0389 0.0703
Brugia malayi Peroxidasin 0.0019 0.0001 0.0001
Brugia malayi Protein kinase domain containing protein 0.0398 0.1376 0.1376
Trichomonas vaginalis AGC family protein kinase 0.0126 0.0389 0.3578
Loa Loa (eye worm) TK/FAK protein kinase 0.029 0.0986 0.2352
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.0211 0.1934
Entamoeba histolytica protein kinase, putative 0.004 0.0078 0.0704
Schistosoma mansoni lipoxygenase 0.0063 0.0162 0.0293
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0001 0.0001
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0057 0.0102
Echinococcus granulosus twitchin 0.005 0.0113 0.0203
Leishmania major N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase 0.0053 0.0123 0.1081
Giardia lamblia Hypothetical protein 0.0083 0.0232 0.2128
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0037 0.0108
Echinococcus multilocularis nmda type glutamate receptor 0.0127 0.0394 0.0711
Onchocerca volvulus 0.0059 0.0147 0.1189
Loa Loa (eye worm) CAMK protein kinase 0.0019 0.0001 0.0002
Echinococcus multilocularis cyclins 0.0019 0.0002 0.0002
Echinococcus granulosus Mastin 0.0034 0.0057 0.0101
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0009 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Echinococcus granulosus nervana 2 0.0022 0.0013 0.0022
Mycobacterium tuberculosis Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) 0.1544 0.5537 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.0495 0.1181
Echinococcus granulosus ephrin type A receptor 4 A 0.0087 0.0248 0.0447
Toxoplasma gondii N-acetylglucosaminylphosphatidylinositol deacetylase 0.0053 0.0123 0.196
Echinococcus multilocularis pyruvate kinase 0.0037 0.0067 0.012
Mycobacterium ulcerans two component transcriptional regulatory protein DevR 0.0024 0.0018 0.0028
Echinococcus granulosus lachesin 0.0019 0.0001 0.0001
Echinococcus multilocularis cyclin dependent kinase 0.0051 0.0116 0.0209
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0084 0.0084
Trypanosoma brucei polo-like protein kinase 0.0159 0.0508 0.1558
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0009 0.0016
Schistosoma mansoni glutaminase 0.0297 0.1011 0.1827
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0192 0.0348
Onchocerca volvulus 0.0026 0.0025 0.0205
Entamoeba histolytica protein kinase 2, putative 0.0027 0.0029 0.0248
Trypanosoma cruzi pyruvate kinase 2, putative 0.0073 0.0195 0.1723
Echinococcus granulosus tyrosine protein kinase otk 0.0019 0.0001 0.0001
Mycobacterium tuberculosis Probable transcriptional regulatory protein KdpE 0.0024 0.0018 0.0029
Mycobacterium tuberculosis Two component response transcriptional regulatory protein PrrA 0.0024 0.0018 0.0029
Trichomonas vaginalis AGC family protein kinase 0.0126 0.0389 0.3578
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Loa Loa (eye worm) CAMK/CAMKL/NUAK protein kinase 0.0533 0.1867 0.4452
Schistosoma mansoni DNA polymerase eta 0.007 0.0185 0.0334
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0009 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.0131 0.1194
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0009 0.0015
Loa Loa (eye worm) hypothetical protein 0.0043 0.0089 0.0212
Onchocerca volvulus 0.0057 0.0137 0.1107
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0053 0.0126 0.0226
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0019 0.0002 0.0002
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0053 0.0126 0.0226
Trichomonas vaginalis CAMK family protein kinase 0.0159 0.0508 0.4668
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0006 0.0072
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0064 0.0064
Echinococcus granulosus epidermal growth factor receptor 0.0463 0.1613 0.2916
Echinococcus granulosus tyrosine protein kinase Lyn 0.0058 0.0142 0.0255
Brugia malayi GnHR receptor homolog 0.0103 0.0305 0.0305
Echinococcus granulosus polycomb protein SCMH1 0.0057 0.0137 0.0246
Loa Loa (eye worm) hypothetical protein 0.0034 0.0057 0.0135
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.0389 0.0704
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.0211 0.1934
Echinococcus granulosus roundabout 2 0.0025 0.0023 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.1085 1
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0027 0.0029 0.0051
Entamoeba histolytica phosphoglycerate kinase, putative 0.0185 0.0603 0.5553
Loa Loa (eye worm) TK/EPH protein kinase 0.0089 0.0256 0.061
Onchocerca volvulus 0.009 0.026 0.2101
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0009 0.0074
Leishmania major mitochondrial DNA polymerase beta 0.0328 0.1124 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.01 0.0239
Trichomonas vaginalis sensor histidine kinase, putative 0.0024 0.0018 0.0148
Leishmania major protein kinase, putative 0.0126 0.0389 0.3455
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0006 0.0037
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0042 0.0084 0.0151
Mycobacterium ulcerans two component transcriptional regulator TrcR 0.0024 0.0018 0.0028
Loa Loa (eye worm) AUR protein kinase 0.0126 0.0389 0.0929
Schistosoma mansoni nephrin 0.0025 0.0023 0.0042
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0025 0.0023 0.0041
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0084 0.0151
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0014 0.0204
Loa Loa (eye worm) hypothetical protein 0.0043 0.0089 0.0212
Loa Loa (eye worm) TK protein kinase 0.0022 0.0012 0.0029
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0035 0.0302
Echinococcus granulosus pyruvate kinase 0.0037 0.0067 0.012
Trypanosoma cruzi Protein kinase B 0.0029 0.0037 0.0312
Entamoeba histolytica cell division protein kinase 2, putative 0.0051 0.0116 0.1057
Brugia malayi Trypsin family protein 0.0034 0.0057 0.0057
Plasmodium falciparum pyruvate kinase 2 0.0037 0.0067 0.1084
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0009 0.0009
Echinococcus multilocularis cyclins 0.0019 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0034 0.0057 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0009 0.0009
Echinococcus multilocularis Mastin 0.0034 0.0057 0.0101
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0034 0.0057 0.0101
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0053 0.0123 0.1081
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0084 0.0253
Echinococcus granulosus cyclins 0.0019 0.0002 0.0002
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0042 0.0084 0.0201
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0025 0.0023 0.0041
Mycobacterium ulcerans arylsulfatase AtsD 0.0083 0.0232 0.0403
Echinococcus granulosus pyruvate kinase 0.0073 0.0195 0.0352
Echinococcus granulosus nervana 2 0.0022 0.0013 0.0022
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0023 0.0015 0.0024
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0051 0.0116 0.0209
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0057 0.0102
Schistosoma mansoni cell adhesion molecule 0.0025 0.0023 0.0042
Trypanosoma brucei unspecified product 0.0029 0.0037 0.0108
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0185 0.0603 1
Brugia malayi mbt repeat family protein 0.0052 0.012 0.012
Giardia lamblia Phosphoglycerate kinase 0.0185 0.0603 0.5553
Schistosoma mansoni kinase 0.0229 0.0763 0.138
Entamoeba histolytica protein kinase domain containing protein 0.0077 0.0211 0.1934
Giardia lamblia Kinase, AGC PKA 0.0027 0.0029 0.0248
Schistosoma mansoni tyrosine kinase 0.0022 0.0011 0.002
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0099 0.087
Brugia malayi Protein kinase domain containing protein 0.029 0.0986 0.0986
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0036 0.0062 0.011
Schistosoma mansoni sex comb on midleg homolog 0.0057 0.0137 0.0248
Echinococcus granulosus tyrosine kinase 0.0049 0.0111 0.02
Plasmodium falciparum flap endonuclease 1 0.0028 0.0035 0.0546
Trichomonas vaginalis receptor histidine kinase, putative 0.0024 0.0018 0.0148
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0126 0.0389 0.3578
Schistosoma mansoni terminal deoxycytidyl transferase 0.0042 0.0084 0.0152
Echinococcus granulosus neuroglian 0.0045 0.0097 0.0174
Mycobacterium ulcerans hypothetical protein 0.0024 0.0018 0.0028
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0053 0.0126 0.0226
Echinococcus multilocularis casein kinase ii subunit alpha 0.0077 0.0211 0.0381
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0006 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0003
Trypanosoma brucei N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase 0.0053 0.0123 0.0373
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0004
Echinococcus granulosus flap endonuclease 1 0.0028 0.0035 0.0061
Brugia malayi Uncharacterized LmbE-like protein, COG2120 containing protein 0.0053 0.0123 0.0123
Trypanosoma cruzi polo-like protein kinase, putative 0.0159 0.0508 0.4508
Echinococcus granulosus pyruvate kinase 0.0037 0.0067 0.012
Echinococcus granulosus cyclin B3 1 0.0019 0.0002 0.0002
Echinococcus granulosus tyrosine protein kinase Fyn 0.0053 0.0126 0.0226
Echinococcus multilocularis cyclins 0.0019 0.0002 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.1085 1
Schistosoma mansoni tyrosine kinase 0.0313 0.1069 0.1933
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0061 0.0523
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0022
Mycobacterium ulcerans adenylylate/guanylate cyclase 0.0024 0.0018 0.0028
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0027 0.0029 0.024
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0009 0.0015
Schistosoma mansoni ap endonuclease 0.002 0.0006 0.0011
Echinococcus multilocularis protein tyrosine kinase 0.0287 0.0975 0.1761
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0009 0.0074
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0068 0.0178 0.1573
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0009 0.0009
Schistosoma mansoni flap endonuclease-1 0.0026 0.0025 0.0045
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0328 0.1124 0.3455
Mycobacterium ulcerans phosphoglycerate kinase 0.0185 0.0603 0.1051
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0146 0.0146
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0192 0.1698
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0064 0.057
Trichomonas vaginalis AGC family protein kinase 0.0126 0.0389 0.3578
Echinococcus granulosus contactin 0.0025 0.0023 0.0041
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0009 0.0016
Echinococcus multilocularis hemicentin 1 0.0019 0.0001 0.0001
Brugia malayi hypothetical protein 0.0043 0.0089 0.0089
Echinococcus granulosus Immunoglobulin 0.0037 0.0066 0.0119
Trypanosoma brucei pyruvate kinase 1, putative 0.0073 0.0195 0.0595
Loa Loa (eye worm) hypothetical protein 0.0048 0.0105 0.0251
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0116 0.1057
Schistosoma mansoni tyrosine kinase 0.0022 0.0011 0.002
Mycobacterium leprae N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase MshB (GlcNAc-Ins deacetylase) 0.0053 0.0123 0.0184
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Echinococcus multilocularis plexin a4 0.0022 0.0012 0.0021
Echinococcus multilocularis peroxidasin 0.0019 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0004
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0208 0.0689 0.1244
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0009 0.0009
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.0012 0.0029
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0057 0.0102
Plasmodium falciparum pyruvate kinase 0.0073 0.0195 0.3214
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0024 0.0302
Mycobacterium ulcerans hypothetical protein 0.0034 0.0057 0.0096
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.012 0.0216
Plasmodium falciparum protein kinase 5 0.0051 0.0116 0.1904
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.0084 0.0149
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0003
Trichomonas vaginalis sensor histidine kinase, putative 0.0024 0.0018 0.0148
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0404 0.1398 0.2527
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0022
Trichomonas vaginalis CAMK family protein kinase 0.0159 0.0508 0.4668
Onchocerca volvulus Pyruvate kinase homolog 0.0073 0.0195 0.1577
Trichomonas vaginalis AGC family protein kinase 0.004 0.0078 0.0704
Mycobacterium ulcerans hypothetical protein 0.0026 0.0025 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.1085 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0022 0.0013 0.0022
Mycobacterium ulcerans two component regulator receiver domain-containing protein 0.0024 0.0018 0.0028
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0053 0.0123 0.1081
Loa Loa (eye worm) plexin A 0.0022 0.0012 0.003
Echinococcus multilocularis pyruvate kinase 0.0073 0.0195 0.0352
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0009 0.0015
Trypanosoma cruzi pyruvate kinase 2, putative 0.0073 0.0195 0.1723
Echinococcus multilocularis N acetylglucosaminyl phosphatidylinositol 0.0053 0.0123 0.0221
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0014 0.0024
Loa Loa (eye worm) cyclin domain-containing protein 0.0019 0.0002 0.0004
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0035 0.0292
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.0131 0.1194
Brugia malayi Flap endonuclease-1 0.0028 0.0035 0.0035
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0126 0.0389 0.0703
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0041 0.008 0.1232
Entamoeba histolytica hypothetical protein 0.0025 0.0024 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Leishmania major pyruvate kinase 0.0073 0.0195 0.1723
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0049 0.0111 0.02
Loa Loa (eye worm) hypothetical protein 0.0056 0.0136 0.0324
Trypanosoma brucei rac serine-threonine kinase, putative 0.004 0.0078 0.0235
Schistosoma mansoni septate junction protein 0.0019 0.0001 0.0002
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.009 0.026 0.047
Mycobacterium ulcerans two component transcriptional regulatory protein TcrX 0.0024 0.0018 0.0028
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0025 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0116 0.021
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0009 0.0015
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0022 0.0012 0.002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0084 0.0734
Loa Loa (eye worm) hypothetical protein 0.0056 0.0136 0.0324
Echinococcus multilocularis cyclins 0.0019 0.0002 0.0002
Loa Loa (eye worm) pyruvate kinase 0.0073 0.0195 0.0465
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0019 0.0001 0.001
Echinococcus granulosus cyclin dependent kinase 1 0.0051 0.0116 0.0209
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.1085 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0019 0.0002 0.0002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0009 0.0015
Echinococcus multilocularis cyclin b3 0.0019 0.0002 0.0002
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.012 0.0286
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0185 0.0603 0.5553
Brugia malayi ephrin receptor 1 precursor 0.0042 0.0083 0.0083
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0116 0.1057
Schistosoma mansoni hypothetical protein 0.0034 0.0057 0.0102
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0001 0.0001
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0009 0.0016
Echinococcus multilocularis L aminoadipate semialdehyde 0.009 0.026 0.0469
Loa Loa (eye worm) TK protein kinase 0.0049 0.0111 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Echinococcus multilocularis expressed protein 0.0036 0.0064 0.0114
Mycobacterium ulcerans hydrolase 0.0083 0.0232 0.0403
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0185 0.0603 0.5553
Echinococcus granulosus glycoprotein Antigen 5 0.0034 0.0057 0.0101
Echinococcus multilocularis tyrosine protein kinase Srms 0.0049 0.0111 0.02
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0025 0.021
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0029 0.0037 0.0312
Echinococcus multilocularis epidermal growth factor receptor 0.0463 0.1613 0.2916
Brugia malayi Sulfatase family protein 0.0083 0.0232 0.0232
Giardia lamblia Aurora kinase 0.0126 0.0389 0.3578
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0006 0.0039
Echinococcus granulosus tyrosine protein kinase Src42A 0.0036 0.0062 0.011
Loa Loa (eye worm) hypothetical protein 0.0034 0.0057 0.0135
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0083 0.0232 0.1878
Loa Loa (eye worm) hypothetical protein 0.0025 0.0023 0.0056
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0084 0.0149
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0019 0.0001 0.0002
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0185 0.0603 0.1025
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0023 0.0015 0.0086
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0146 0.0263
Trypanosoma brucei aurora B kinase 0.0126 0.0389 0.1194
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0034 0.0057 0.0057
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0192 0.0587
Brugia malayi hypothetical protein 0.0023 0.0014 0.0014
Mycobacterium ulcerans arylsulfatase AtsB 0.0083 0.0232 0.0403
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0022 0.0012 0.002
Trypanosoma brucei pyruvate kinase 1 0.0073 0.0195 0.0595
Mycobacterium ulcerans sulfatase 0.0083 0.0232 0.0403
Schistosoma mansoni serine/threonine protein kinase 0.0159 0.0508 0.0918
Loa Loa (eye worm) MBCTL1 0.0059 0.0146 0.0348
Chlamydia trachomatis phosphoglycerate kinase 0.0185 0.0603 1
Echinococcus multilocularis RUN 0.0023 0.0014 0.0024
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0025 0.0043
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0022 0.0013 0.0022
Chlamydia trachomatis two component regulatory system response regulator/ATPase 0.0024 0.0018 0.0268
Brugia malayi nuclear hormone receptor 0.0021 0.0009 0.0009
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0116 0.1057
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0019 0.0001 0.0002
Echinococcus multilocularis tyrosine protein kinase Abl 0.0022 0.0011 0.0018
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.0496 0.4404
Mycobacterium ulcerans arylsulfatase AtsD 0.0083 0.0232 0.0403
Schistosoma mansoni tyrosine kinase 0.03 0.1019 0.1843
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0048 0.0105 0.0189
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.1085 1
Leishmania major casein kinase II, putative 0.0077 0.0211 0.1868
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0042 0.0084 0.0152
Echinococcus multilocularis cyclins 0.0019 0.0002 0.0002
Schistosoma mansoni cyclin B 0.0019 0.0002 0.0003
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0009 0.0016
Trichomonas vaginalis AGC family protein kinase 0.004 0.0078 0.0704
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0084 0.0253
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0009 0.0015
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0027 0.0029 0.0449
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0318 0.1085 1
Brugia malayi Prion-like- 0.0019 0.0001 0.0001
Schistosoma mansoni cell adhesion molecule 0.0054 0.0128 0.0231
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0126 0.0389 0.3578
Brugia malayi hypothetical protein 0.0083 0.0232 0.0232
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0084 0.0253
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0009 0.0022
Schistosoma mansoni rab6-interacting 0.0023 0.0014 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0232 0.2128
Entamoeba histolytica protein kinase, putative 0.0126 0.0389 0.3578
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0099 0.087
Loa Loa (eye worm) hypothetical protein 0.0034 0.0057 0.0135
Mycobacterium ulcerans arylsulfatase, AslA 0.0083 0.0232 0.0403
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0025 0.0041
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0313 0.1069 0.1932
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.012 0.0216
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0006 0.0037
Schistosoma mansoni polycystin 1-related 0.0023 0.0014 0.0025
Brugia malayi Protein kinase domain containing protein 0.0051 0.0116 0.0116
Echinococcus multilocularis rac serine:threonine kinase 0.0029 0.0037 0.0065
Trichomonas vaginalis AGC family protein kinase 0.004 0.0078 0.0704
Entamoeba histolytica protein kinase, putative 0.0038 0.007 0.0629
Toxoplasma gondii pyruvate kinase PyKII 0.0037 0.0067 0.102
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0024 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0009 0.0009
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0022 0.0011 0.0018

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = -8.3 Inhibition of [3H]-glycine to glycine binding site, associated with the N-methyl-D-aspartate glutamate receptor 1 in crude synaptic membranes prepared from adult rat cerebral cortex. ChEMBL. 9083472
Log Ki (binding) = 8.3 Inhibition of [3H]-glycine to glycine binding site, associated with the N-methyl-D-aspartate glutamate receptor 1 in crude synaptic membranes prepared from adult rat cerebral cortex. ChEMBL. 9083472

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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