Detailed information for compound 305210

Basic information

Technical information
  • TDR Targets ID: 305210
  • Name: 4-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]butyl dihydrogen phosphate
  • MW: 333.238 | Formula: C10H16N5O6P
  • H donors: 4 H acceptors: 7 LogP: -1.5 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nc(O)c2c(n1)n(COCCCCOP(=O)(O)O)cn2
  • InChi: 1S/C10H16N5O6P/c11-10-13-8-7(9(16)14-10)12-5-15(8)6-20-3-1-2-4-21-22(17,18)19/h5H,1-4,6H2,(H2,17,18,19)(H3,11,13,14,16)
  • InChiKey: FRXGIEXXSZGHSR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(2-azanyl-6-oxo-3H-purin-9-yl)methoxy]butyl dihydrogen phosphate
  • 4-[(2-amino-6-keto-3H-purin-9-yl)methoxy]butyl dihydrogen phosphate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens purine nucleoside phosphorylase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase Get druggable targets OG5_128114 All targets in OG5_128114
Echinococcus granulosus purine nucleoside phosphorylase Get druggable targets OG5_128114 All targets in OG5_128114
Trichomonas vaginalis purine nucleoside phosphorylase I, putative Get druggable targets OG5_128114 All targets in OG5_128114
Echinococcus granulosus purine nucleoside phosphorylase Get druggable targets OG5_128114 All targets in OG5_128114
Echinococcus multilocularis purine nucleoside phosphorylase Get druggable targets OG5_128114 All targets in OG5_128114
Candida albicans similar to human purine nucleoside phosphorylase Get druggable targets OG5_128114 All targets in OG5_128114
Echinococcus granulosus purine nucleoside phosphorylase Get druggable targets OG5_128114 All targets in OG5_128114
Schistosoma mansoni purine nucleoside phosphorylase Get druggable targets OG5_128114 All targets in OG5_128114
Echinococcus granulosus purine nucleoside phosphorylase Get druggable targets OG5_128114 All targets in OG5_128114
Echinococcus granulosus purine nucleoside phosphorylase Get druggable targets OG5_128114 All targets in OG5_128114
Echinococcus multilocularis purine nucleoside phosphorylase Get druggable targets OG5_128114 All targets in OG5_128114
Echinococcus multilocularis purine nucleoside phosphorylase Get druggable targets OG5_128114 All targets in OG5_128114
Schistosoma japonicum ko:K03783 purine-nucleoside phosphorylase, putative Get druggable targets OG5_128114 All targets in OG5_128114
Onchocerca volvulus Purine nucleoside phosphorylase homolog Get druggable targets OG5_128114 All targets in OG5_128114
Echinococcus multilocularis purine nucleoside phosphorylase Get druggable targets OG5_128114 All targets in OG5_128114
Schistosoma japonicum Purine nucleoside phosphorylase, putative Get druggable targets OG5_128114 All targets in OG5_128114
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128114 All targets in OG5_128114
Echinococcus multilocularis purine nucleoside phosphorylase Get druggable targets OG5_128114 All targets in OG5_128114
Mycobacterium ulcerans purine nucleoside phosphorylase Get druggable targets OG5_128114 All targets in OG5_128114
Schistosoma mansoni purine nucleoside phosphorylase Get druggable targets OG5_128114 All targets in OG5_128114
Echinococcus multilocularis purine nucleoside phosphorylase Get druggable targets OG5_128114 All targets in OG5_128114
Echinococcus granulosus purine nucleoside phosphorylase Get druggable targets OG5_128114 All targets in OG5_128114
Candida albicans similar to human purine nucleoside phosphorylase Get druggable targets OG5_128114 All targets in OG5_128114
Echinococcus multilocularis purine nucleoside phosphorylase Get druggable targets OG5_128114 All targets in OG5_128114
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate Get druggable targets OG5_128114 All targets in OG5_128114
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) Get druggable targets OG5_128114 All targets in OG5_128114
Echinococcus granulosus purine nucleoside phosphorylase Get druggable targets OG5_128114 All targets in OG5_128114
Echinococcus granulosus purine nucleoside phosphorylase Get druggable targets OG5_128114 All targets in OG5_128114
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein Get druggable targets OG5_128114 All targets in OG5_128114
Echinococcus multilocularis purine nucleoside phosphorylase Get druggable targets OG5_128114 All targets in OG5_128114
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) Get druggable targets OG5_128114 All targets in OG5_128114
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei methylthioadenosine phosphorylase, putative purine nucleoside phosphorylase 289 aa 255 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0032 0.0038 0.0876
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0032 0.0038 0.0876
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0016 0.0247
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0004 0.0057
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0005 0.0101
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0016 0.0057
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0021 0.0022 0.0345
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0007 0.0106
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0032 0.0038 1
Echinococcus multilocularis uridine phosphorylase 1 0.0032 0.0038 0.0596
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0007 0.0106
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0032 0.0038 0.0138
Trichomonas vaginalis ap endonuclease, putative 0.002 0.002 0.0461
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0021 0.0479
Schistosoma mansoni cpg binding protein 0.0068 0.0091 0.1439
Brugia malayi Telomerase reverse transcriptase 0.4925 0.7266 1
Toxoplasma gondii hypothetical protein 0.009 0.0124 0.0455
Trypanosoma brucei telomerase reverse transcriptase 0.1851 0.2725 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0007 0.0141
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0007 0.0106
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0016 0.0057
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0445
Brugia malayi Importin beta-1 subunit 0.0031 0.0036 0.005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0001 0.0000098982
Echinococcus granulosus importin subunit beta 1 0.0031 0.0036 0.057
Schistosoma mansoni glutaminase 0.0291 0.0421 0.6635
Loa Loa (eye worm) helicase DNA-binding protein 0.0012 0.0009 0.0191
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0007 0.0009
Echinococcus granulosus global transcription activator snf2l2 0.0072 0.0097 0.1521
Echinococcus granulosus purine nucleoside phosphorylase 0.0154 0.0218 0.3433
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0141
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0077
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0032 0.0038 0.0336
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0032 0.0038 0.0893
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0032 0.0116
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0322 0.0466 0.1711
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0004 0.0057
Echinococcus granulosus uridine phosphorylase 1 0.0032 0.0038 0.0596
Echinococcus multilocularis muscleblind protein 0.0159 0.0226 0.356
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.002 0.0074
Loa Loa (eye worm) hypothetical protein 0.0159 0.0226 0.4753
Echinococcus granulosus flap endonuclease 1 0.0028 0.0032 0.0501
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0154 0.0218 0.8965
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0028 0.0632
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0087 0.1366
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0021 0.0334
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0016 0.0057
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.0216 0.0792
Echinococcus multilocularis disco interacting protein 2 0.0041 0.0051 0.081
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0105 0.0147 0.2436
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0058 0.0211
Echinococcus multilocularis purine nucleoside phosphorylase 0.0122 0.0171 0.2692
Schistosoma mansoni purine nucleoside phosphorylase 0.0154 0.0218 0.3433
Brugia malayi Disco-interacting protein 2 homolog 0.0041 0.0051 0.0071
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0021 0.0498
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0007 0.0009
Brugia malayi RNA, U transporter 1 0.0087 0.012 0.0165
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0021 0.0077
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0002 0.0032
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0032 0.0038 0.0796
Brugia malayi MH1 domain containing protein 0.0009 0.0004 0.0005
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0016 0.0247
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0032 0.0038 0.0893
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0021 0.0479
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0007 0.0106
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.002 0.0321
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0077
Brugia malayi steroid hormone receptor 0.0011 0.0007 0.0009
Plasmodium vivax importin-beta 2, putative 0.0031 0.0036 0.0133
Schistosoma mansoni hypothetical protein 0.0181 0.0258 0.4058
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0012 0.0009 0.0143
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.002 0.0074
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0007 0.0007
Trypanosoma brucei unspecified product 0.0014 0.0012 0.0042
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0021 0.0022 0.008
Brugia malayi MH2 domain containing protein 0.0127 0.0179 0.0246
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.002 0.021
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0028 0.0632
Brugia malayi Smad1 0.0009 0.0004 0.0005
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0047 0.0747
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0007 0.0106
Echinococcus multilocularis purine nucleoside phosphorylase 0.0154 0.0218 0.3433
Schistosoma mansoni smad1 5 8 and 0.0009 0.0004 0.0057
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0032 0.0116
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0021 0.0244
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0032 0.0038 0.0876
Schistosoma mansoni uridine phosphorylase 0.0032 0.0038 0.0596
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0016 0.0022
Echinococcus granulosus purine nucleoside phosphorylase 0.0154 0.0218 0.3433
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0371 0.0538 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.017 0.0241 1
Entamoeba histolytica hypothetical protein 0.0038 0.0047 0.0522
Echinococcus granulosus helicase 0.0006 0.00000041601 0.00000000010135
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.0179 0.376
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0007 0.0009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0007 0.0106
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0072 0.0265
Leishmania major methylthioadenosine phosphorylase, putative 0.0032 0.0038 0.0138
Brugia malayi uridine phosphorylase family protein 0.0032 0.0038 0.0052
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0021 0.0077
Leishmania major DNA polymerase eta, putative 0.0021 0.0021 0.0077
Schistosoma mansoni ap endonuclease 0.002 0.002 0.0321
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0007 0.0106
Toxoplasma gondii DNA methyltransferase 2, putative 0.0021 0.0022 0.008
Echinococcus granulosus purine nucleoside phosphorylase 0.0154 0.0218 0.3433
Plasmodium falciparum importin beta, putative 0.0031 0.0036 0.0133
Echinococcus multilocularis dnaJ subfamily B 0.0436 0.0635 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0021 0.0015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0141
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0032 0.0038 0.0138
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0021 0.0334
Brugia malayi Flap endonuclease-1 0.0028 0.0032 0.0044
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0007 0.0106
Echinococcus multilocularis Chromo domain 0.0012 0.0009 0.0143
Plasmodium vivax telomerase reverse transcriptase, putative 0.1851 0.2725 1
Schistosoma mansoni uridine phosphorylase 0.0032 0.0038 0.0596
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0058 0.0211
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0005 0.0075
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0016 0.0247
Toxoplasma gondii phosphorylase family protein 0.0032 0.0038 0.0138
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0009 0.0143
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0007 0.0106
Echinococcus granulosus purine nucleoside phosphorylase 0.0154 0.0218 0.3433
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0032 0.0038 0.0336
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0032 0.0038 0.0138
Giardia lamblia Telomerase catalytic subunit 0.1851 0.2725 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0036 0.0761
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0077
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0021 0.0022 0.008
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0032 0.0038 0.0876
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0012 0.0042
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0007 0.0106
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0021 0.0334
Treponema pallidum uridine phosphorylase (udp) 0.0032 0.0038 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0154 0.0218 0.3433
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0007 0.0141
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0322 0.0466 0.1711
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0007 0.0106
Echinococcus granulosus purine nucleoside phosphorylase 0.0154 0.0218 0.3433
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0016 0.0057
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0007 0.0106
Leishmania major telomerase reverse transcriptase, putative 0.1851 0.2725 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.009 0.0124 0.0455
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0041 0.0051 0.081
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0141
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0007 0.0009
Schistosoma mansoni helicase 0.0006 0.00000041601 0.0000065514
Loa Loa (eye worm) hypothetical protein 0.0006 0 0.0008
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0032 0.0038 0.0336
Schistosoma mansoni hypothetical protein 0.0181 0.0258 0.4058
Echinococcus multilocularis Smad4 0.0009 0.0004 0.0057
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0021 0.0077
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0141
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0058 0.0211
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0007 0.0009
Plasmodium vivax DNA repair protein REV1, putative 0.0006 0 0.0001
Echinococcus multilocularis global transcription activator snf2l2 0.0072 0.0097 0.1521
Brugia malayi MH2 domain containing protein 0.0009 0.0004 0.0005
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0021 0.0029
Loa Loa (eye worm) hypothetical protein 0.0122 0.0171 0.3594
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0141
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0032 0.0038 0.0138
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0154 0.0218 0.5171
Treponema pallidum pfs protein (pfs) 0.0032 0.0038 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0007 0.0141
Trichomonas vaginalis ap endonuclease, putative 0.002 0.002 0.0461
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0021 0.0334
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.0216 0.0792
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0009 0.0143
Echinococcus multilocularis snurportin 1 0.0328 0.0476 0.749
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0021 0.0022 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0077
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0002 0.0032
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0032 0.022
Entamoeba histolytica hypothetical protein 0.0038 0.0047 0.0522
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0004 0.0057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0016 0.0058
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0032 0.0038 0.0336
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0007 0.0106
Entamoeba histolytica hypothetical protein 0.0105 0.0147 0.2436
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0077
Echinococcus granulosus polybromo 1 0.0007 0.0001 0.0009
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0016 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0077
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.0179 0.376
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0021 0.0077
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0036 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0007 0.0009
Entamoeba histolytica hypothetical protein 0.0038 0.0047 0.0522
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0007 0.0106
Schistosoma mansoni hypothetical protein 0.0014 0.0012 0.0184
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0021 0.0498
Mycobacterium tuberculosis Conserved hypothetical protein 0.0032 0.0038 0.0982
Brugia malayi CXXC zinc finger family protein 0.0066 0.0089 0.0122
Echinococcus granulosus dnaJ subfamily B 0.0436 0.0635 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0322 0.0466 0.1711
Schistosoma mansoni helicase 0.0072 0.0097 0.1521
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0077
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0016 0.0057
Schistosoma mansoni importin beta-1 0.0031 0.0036 0.057
Schistosoma mansoni ap endonuclease 0.002 0.002 0.0321
Echinococcus multilocularis purine nucleoside phosphorylase 0.0154 0.0218 0.3433
Schistosoma mansoni cpg binding protein 0.0068 0.0091 0.1439
Toxoplasma gondii hypothetical protein 0.0052 0.0068 0.0247
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0154 0.0218 0.5162
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0007 0.0009
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.002 0.0074
Toxoplasma gondii phosphorylase family protein 0.0032 0.0038 0.0138
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0021 0.0334
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0154 0.0218 0.03
Brugia malayi polybromodomain protein 0.0007 0.0001 0.0001
Trypanosoma brucei unspecified product 0.0021 0.0021 0.0077
Echinococcus granulosus disco interacting protein 2 0.0041 0.0051 0.081
Brugia malayi Muscleblind-like protein 0.0159 0.0226 0.0311
Brugia malayi isocitrate dehydrogenase 0.0017 0.0016 0.0022
Echinococcus granulosus muscleblind protein 0.0159 0.0226 0.356
Plasmodium falciparum telomerase reverse transcriptase 0.1851 0.2725 1
Echinococcus multilocularis polybromo 1 0.0007 0.0001 0.0009
Schistosoma mansoni Smad4 0.0009 0.0004 0.0057
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.002 0.0479
Echinococcus granulosus snurportin 1 0.0328 0.0476 0.749
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0032 0.0038 0.0138
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0007 0.0141
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0032 0.0038 0.0876
Echinococcus granulosus purine nucleoside phosphorylase 0.0154 0.0218 0.3433
Leishmania major modification methylase-like protein 0.0021 0.0022 0.008
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0047 0.0747
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0016 0.0057
Brugia malayi MTAP 0.0032 0.0038 0.0052
Schistosoma mansoni DNA polymerase eta 0.0021 0.0021 0.0334
Echinococcus multilocularis muscleblind protein 1 0.0159 0.0226 0.356
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.002 0.5
Loa Loa (eye worm) BRM protein 0.0046 0.0058 0.1227
Echinococcus multilocularis purine nucleoside phosphorylase 0.0154 0.0218 0.3433
Mycobacterium ulcerans glutaminase 0.0291 0.0421 1
Trichomonas vaginalis lymphoid specific helicase, putative 0.0013 0.001 0.0214
Echinococcus granulosus methylthioadenosine phosphorylase 0.0032 0.0038 0.0596
Plasmodium falciparum flap endonuclease 1 0.0028 0.0032 0.0117
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0007 0.0106
Loa Loa (eye worm) hypothetical protein 0.0041 0.0051 0.1082
Leishmania major mitochondrial DNA polymerase beta 0.0322 0.0466 0.1711
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0141
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0001 0.0000098982
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0002 0.0032
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1851 0.2725 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.0077
Schistosoma mansoni methylthioadenosine phosphorylase 0.0032 0.0038 0.0596
Echinococcus granulosus BRK domain containing protein 0.0012 0.0009 0.0143
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0002 0.0032
Toxoplasma gondii RNA-directed DNA polymerase 0.1851 0.2725 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0077
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0016 0.0247
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0032 0.0116
Giardia lamblia UPL-1 0.0032 0.0038 0.0138
Loa Loa (eye worm) glutaminase 2 0.0291 0.0421 0.8859
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.0077
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0 0.0004
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0328 0.0476 1
Giardia lamblia DINP protein human, muc B family 0.0021 0.0021 0.0077
Chlamydia trachomatis AMP nucleosidase 0.0032 0.0038 0.5
Brugia malayi nuclear hormone receptor 0.0011 0.0007 0.0009
Schistosoma mansoni helicase 0.0006 0.00000041601 0.0000065514
Brugia malayi SET domain containing protein 0.0007 0.0001 0.0002
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0032 0.0038 0.0138
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0032 0.0038 0.0139
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.002 0.0074
Loa Loa (eye worm) hypothetical protein 0.0159 0.0226 0.4753
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0007 0.0009
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0009 0.0143
Leishmania major nucleoside phosphorylase-like protein 0.0032 0.0038 0.0138
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0047 0.0747
Schistosoma mansoni polybromo-1 0.0007 0.0001 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0012 0.0042
Echinococcus granulosus cpg binding protein 0.0068 0.0091 0.1439
Echinococcus granulosus dna polymerase kappa 0.0021 0.0021 0.0334
Onchocerca volvulus 0.0066 0.0089 0.0089
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0032 0.0038 0.0138
Plasmodium vivax DEAD/DEAH helicase, putative 0.0011 0.0007 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0038 0.0876
Schistosoma mansoni hypothetical protein 0.0012 0.0009 0.0143
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0079 0.029
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.002 0.0429
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0007 0.0106
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0154 0.0218 1
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0032 0.0669
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0032 0.0501
Echinococcus granulosus purine nucleoside phosphorylase 0.0154 0.0218 0.3433
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0001 0.0000098982
Loa Loa (eye worm) hypothetical protein 0.0006 0 0.0005
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0009 0.0143
Echinococcus multilocularis smad 0.0009 0.0004 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0007 0.0009
Echinococcus granulosus DNA methyltransferase 2, putative 0.0021 0.0022 0.0345
Schistosoma mansoni methylthioadenosine phosphorylase 0.0032 0.0038 0.0596
Toxoplasma gondii Purine nucleoside phosphorylase 0.0032 0.0038 0.0138
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0058 0.0211
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0007 0.0106
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0007 0.0106
Echinococcus multilocularis geminin 0.0181 0.0258 0.4058
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0007 0.0106
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0021 0.0022 0.0345
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0007 0.0007
Brugia malayi MH1 domain containing protein 0.0009 0.0004 0.0005
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0016 0.0247
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0005 0.0075
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0021 0.0022 0.008
Plasmodium falciparum DEAD/DEAH box helicase, putative 0.0011 0.0007 0.0027
Echinococcus multilocularis BRK domain 0.0012 0.0009 0.0143
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0021 0.0077
Trichomonas vaginalis glutaminase, putative 0.0291 0.0421 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0038 0.0876
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0012 0.0042
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0036 0.057
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0077
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0154 0.0218 0.0799
Echinococcus granulosus smad 0.0009 0.0004 0.0057
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0007 0.0009
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0007 0.0106
Toxoplasma gondii exonuclease III APE 0.002 0.002 0.0074
Schistosoma mansoni cpg binding protein 0.0066 0.0089 0.1398
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0001 0.0000098982
Echinococcus granulosus geminin 0.0181 0.0258 0.4058
Echinococcus multilocularis purine nucleoside phosphorylase 0.0122 0.0171 0.2692
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0021 0.0445
Brugia malayi ecdysteroid receptor 0.0011 0.0007 0.0009
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0007 0.0141
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0032 0.0038 0.0138
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0007 0.0141
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0032 0.0116
Schistosoma mansoni flap endonuclease-1 0.0025 0.0028 0.0439
Echinococcus granulosus Chromo domain 0.0012 0.0009 0.0143
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0077
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0032 0.0038 0.0876
Schistosoma mansoni hypothetical protein 0.0328 0.0476 0.749
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0032 0.0116
Echinococcus multilocularis purine nucleoside phosphorylase 0.0154 0.0218 0.3433
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0004 0.0057
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0001 0.0000098982
Trypanosoma brucei uridine phosphorylase 0.0032 0.0038 0.0138
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0007 0.0106
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0007 0.0106
Onchocerca volvulus 0.0041 0.0051 0.0051
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1851 0.2725 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0007 0.0009
Onchocerca volvulus 0.0011 0.0007 0.0007
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0002 0.0032
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0007 0.0106
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0007 0.0106
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0007 0.0106
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0021 0.0244
Plasmodium vivax helicase, putative 0.0006 0.00000041601 0.0000015268
Mycobacterium ulcerans hypothetical protein 0.017 0.0241 0.5726
Schistosoma mansoni smad1 5 8 and 0.0009 0.0004 0.0057
Leishmania major DNA polymerase kappa, putative 0.0021 0.0021 0.0077
Echinococcus multilocularis dna polymerase eta 0.0021 0.0021 0.0334
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0141
Entamoeba histolytica hypothetical protein 0.0025 0.0028 0.0139
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.002 0.0075
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.002 0.0074
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0009 0.0143
Echinococcus granulosus dna polymerase eta 0.0021 0.0021 0.0334
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0013 0.001 0.0036
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0016 0.0247
Schistosoma mansoni purine nucleoside phosphorylase 0.0154 0.0218 0.3433
Echinococcus granulosus Smad4 0.0009 0.0004 0.0057
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0016 0.0247
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0016 0.0058
Leishmania major importin beta-1 subunit, putative 0.0025 0.0028 0.0101
Entamoeba histolytica hypothetical protein 0.0038 0.0047 0.0522
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0122 0.0171 0.2692
Brugia malayi MH2 domain containing protein 0.0009 0.0004 0.0005
Schistosoma mansoni smad 0.0009 0.0004 0.0057
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0028 0.0101
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0009 0.0143
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0007 0.0106
Schistosoma mansoni hypothetical protein 0.0038 0.0047 0.0747
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0007 0.0009
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0154 0.0218 0.0218
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0032 0.0038 0.0336
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0032 0.0038 0.0336
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0007 0.0007
Giardia lamblia DNA repair protein RAD52 0.0371 0.0538 0.1975
Brugia malayi BRM protein 0.0072 0.0097 0.0133
Loa Loa (eye worm) BRM protein 0.0037 0.0045 0.0956
Entamoeba histolytica hypothetical protein 0.0032 0.0038 0.0336
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0021 0.0022 0.0029
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0001 0.0000098982
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0001 0.0000098982
Schistosoma mansoni coup transcription factor 0.0011 0.0007 0.0106
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0036 0.0132
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0009 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0007 0.0141
Schistosoma mansoni smad1 5 8 and 0.0009 0.0004 0.0057
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0032 0.0117
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0001 0.0000098982
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0032 0.0732
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0028 0.0632
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.002 0.0075
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0016 0.033
Plasmodium falciparum purine nucleoside phosphorylase 0.0032 0.0038 0.0139
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0036 0.0132
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0011 0.0007 0.0026
Mycobacterium tuberculosis Hypothetical protein 0.0032 0.0038 0.0982
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0032 0.0038 0.0876
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0004 0.0076
Echinococcus multilocularis cpg binding protein 0.0068 0.0091 0.1439
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0007 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0007 0.0009
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0007 0.0106
Loa Loa (eye worm) Smad1 0.0009 0.0004 0.0076
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.0077
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0152 0.0216 0.0792
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0007 0.0106
Loa Loa (eye worm) uridine phosphorylase 0.0032 0.0038 0.0796
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0007 0.0106
Schistosoma mansoni methylthioadenosine phosphorylase 0.0032 0.0038 0.0596
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0007 0.0141
Brugia malayi nuclear receptor NHR-88 0.0011 0.0007 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0007 0.0009
Brugia malayi glutaminase DH11.1 0.0291 0.0421 0.058
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0007 0.0106
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0005 0.0006
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0004 0.0076
Trypanosoma brucei unspecified product 0.0014 0.0012 0.0042
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0032 0.0038 0.0982
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0007 0.0009
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.002 0.0028
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0021 0.0077
Echinococcus multilocularis helicase 0.0006 0.00000041601 0.00000000010135
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0004 0.0057
Plasmodium falciparum DNA repair protein REV1, putative 0.0006 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0141
Schistosoma mansoni hypothetical protein 0.0436 0.0635 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0066 0.0089 0.1867
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0021 0.0029
Loa Loa (eye worm) glutaminase 0.0291 0.0421 0.8859
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.002 0.0321
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0032 0.0038 0.0596
Echinococcus multilocularis purine nucleoside phosphorylase 0.0154 0.0218 0.3433
Brugia malayi hypothetical protein 0.0038 0.0047 0.0065
Echinococcus multilocularis purine nucleoside phosphorylase 0.0154 0.0218 0.3433

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.051 uM In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes. ChEMBL. 8632418
Ki (binding) = 0.051 uM In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes. ChEMBL. 8632418

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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