Detailed information for compound 306654

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 473.56 | Formula: C29H31NO5
  • H donors: 1 H acceptors: 3 LogP: 6.82 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1c(OCCCCOc2cccc(c2)CCC(=O)O)ccc2c1onc2c1ccccc1
  • InChi: 1S/C29H31NO5/c1-2-9-24-26(16-15-25-28(30-35-29(24)25)22-11-4-3-5-12-22)34-19-7-6-18-33-23-13-8-10-21(20-23)14-17-27(31)32/h3-5,8,10-13,15-16,20H,2,6-7,9,14,17-19H2,1H3,(H,31,32)
  • InChiKey: DQINTDUSYVMMHS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens peroxisome proliferator-activated receptor alpha Starlite/ChEMBL References
Homo sapiens peroxisome proliferator-activated receptor gamma Starlite/ChEMBL References
Homo sapiens peroxisome proliferator-activated receptor delta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni nuclear hormone receptor superfamily protein-related Get druggable targets OG5_137778 All targets in OG5_137778
Schistosoma japonicum ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative Get druggable targets OG5_137778 All targets in OG5_137778
Schistosoma japonicum IPR008946,Nuclear receptor, ligand-binding,domain-containing Get druggable targets OG5_137778 All targets in OG5_137778
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi ecdysteroid receptor peroxisome proliferator-activated receptor alpha 468 aa 397 aa 25.4 %
Echinococcus granulosus ecdysone induced protein 78C peroxisome proliferator-activated receptor gamma 477 aa 447 aa 28.2 %
Brugia malayi ecdysteroid receptor peroxisome proliferator-activated receptor delta 441 aa 369 aa 24.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii PAN/Apple domain-containing protein 0.0107 0.0277 0.0925
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0084 0.0209 0.0207
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0025 0.02
Onchocerca volvulus 0.0024 0.0028 0.0245
Schistosoma mansoni cercarial elastase (S01 family) 0.0084 0.0209 0.1647
Echinococcus granulosus pyruvate kinase 0.0099 0.0253 0.1261
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.0646 0.3236
Onchocerca volvulus 0.0107 0.0277 0.2582
Loa Loa (eye worm) Notch2 0.0016 0.0003 0.0015
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.003 0.0044 0.0364
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0042 0.0081 0.0683
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0081 0.068
Schistosoma mansoni hypothetical protein 0.0113 0.0294 0.2323
Echinococcus multilocularis protein jagged 1 0.0016 0.0003 0.0002
Onchocerca volvulus 0.0284 0.0812 0.7585
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.0079 0.0658
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0055 0.0457
Onchocerca volvulus 0.0084 0.0209 0.1943
Brugia malayi EGF-like domain containing protein 0.0016 0.0003 0.0015
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0055 0.0426
Onchocerca volvulus Pyruvate kinase homolog 0.0099 0.0253 0.2353
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0233 0.1163
Schistosoma mansoni cercarial elastase (S01 family) 0.0084 0.0209 0.1647
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0084 0.1767
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0404 0.1173 1
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0042 0.0081 0.191
Onchocerca volvulus 0.0107 0.0277 0.2582
Leishmania major 4-coumarate:coa ligase-like protein 0.0144 0.0388 0.3576
Onchocerca volvulus 0.0016 0.0003 0.0017
Mycobacterium ulcerans acyl-CoA synthetase 0.0144 0.0388 1
Echinococcus multilocularis protein patched 0.0173 0.0477 0.0476
Mycobacterium ulcerans acyl-CoA synthetase 0.0144 0.0388 1
Toxoplasma gondii patched family protein 0.0024 0.0028 0.0082
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0025 0.012
Echinococcus granulosus tumor protein p63 0.0675 0.1994 1
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0042 0.0081 0.0683
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0049 0.0101 0.0329
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.0079 0.0658
Giardia lamblia Pyruvate kinase 0.0051 0.0107 0.4165
Loa Loa (eye worm) hypothetical protein 0.0099 0.0252 0.214
Loa Loa (eye worm) hypothetical protein 0.0144 0.0388 0.3298
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0049
Echinococcus granulosus replication factor c subunit 1 0.003 0.0043 0.021
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.003 0.0043 1
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.0079 0.0657
Onchocerca volvulus 0.0042 0.0081 0.0746
Loa Loa (eye worm) hypothetical protein 0.0107 0.0277 0.2353
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0084 0.0209 0.1647
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0102 0.0261 0.6638
Brugia malayi EGF-like domain containing protein 0.0016 0.0003 0.0015
Echinococcus multilocularis cpg binding protein 0.0031 0.0048 0.0047
Onchocerca volvulus 0.0084 0.0209 0.1943
Echinococcus granulosus Mastin 0.0084 0.0209 0.1041
Brugia malayi hypothetical protein 0.0017 0.0004 0.0023
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0143 0.1124
Echinococcus multilocularis neurogenic locus notch protein 4 0.0016 0.0003 0.0002
Echinococcus granulosus Protein patched homolog 1 0.0173 0.0477 0.2387
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0032 0.0097
Loa Loa (eye worm) hypothetical protein 0.0034 0.0055 0.0457
Schistosoma mansoni cercarial elastase (S01 family) 0.0084 0.0209 0.1647
Echinococcus multilocularis pyruvate kinase 0.0051 0.0107 0.0106
Plasmodium vivax pyruvate kinase 2, putative 0.0051 0.0107 0.0928
Echinococcus granulosus neural cadherin 0.0016 0.0003 0.0009
Entamoeba histolytica acyl-coA synthetase, putative 0.0144 0.0388 0.3257
Schistosoma mansoni hypothetical protein 0.0041 0.0079 0.0612
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0049
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0042 0.0081 0.191
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0049 0.0101 0.0868
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0042 0.0081 0.0683
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0142 0.3525
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0055 0.0426
Schistosoma mansoni cercarial elastase (S01 family) 0.0084 0.0209 0.1647
Loa Loa (eye worm) hypothetical protein 0.0107 0.0277 0.2353
Toxoplasma gondii patched family protein 0.0024 0.0028 0.0082
Echinococcus granulosus transmembrane protease serine 3 0.0084 0.0209 0.1041
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0043 0.0911
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0144 0.0388 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.0277 0.2353
Schistosoma mansoni hypothetical protein 0.0369 0.1069 0.848
Brugia malayi hypothetical protein 0.0229 0.0646 0.5501
Entamoeba histolytica hypothetical protein 0.0113 0.0294 0.2449
Entamoeba histolytica acyl-CoA synthetase, putative 0.0144 0.0388 0.3257
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0009 0.0196
Echinococcus granulosus protein jagged 2 0.0016 0.0003 0.0009
Brugia malayi Kringle domain containing protein 0.0369 0.1069 0.9113
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0042 0.0081 0.068
Loa Loa (eye worm) hypothetical protein 0.0107 0.0277 0.2353
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0233 0.1977
Loa Loa (eye worm) trypsin family protein 0.0084 0.0209 0.177
Leishmania major acetyl-CoA synthetase, putative 0.0042 0.0081 0.0683
Brugia malayi Cadherin domain containing protein 0.0016 0.0003 0.0015
Brugia malayi PAN domain containing protein 0.0107 0.0277 0.2353
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Treponema pallidum DNA ligase (lig) 0.003 0.0043 1
Echinococcus multilocularis expressed conserved protein 0.0379 0.1099 0.1098
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.003 0.0043 0.0915
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0043 0.0354
Brugia malayi PAN domain containing protein 0.0107 0.0277 0.2353
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0055 0.0457
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0009 0.0007
Trypanosoma brucei pyruvate kinase 1, putative 0.0099 0.0253 0.4296
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0042 0.0081 0.1096
Toxoplasma gondii hypothetical protein 0.0107 0.0277 0.0925
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0015
Schistosoma mansoni laminin gamma-3 chain 0.0016 0.0003 0.0014
Loa Loa (eye worm) PAN domain-containing protein 0.0107 0.0277 0.2353
Trichomonas vaginalis replication factor C large subunit, putative 0.003 0.0043 0.0911
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0015
Brugia malayi Pax transcription activation domain interacting protein 0.003 0.0043 0.0358
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0055 0.0502
Schistosoma mansoni ap endonuclease 0.0018 0.0009 0.0057
Schistosoma mansoni hypothetical protein 0.0016 0.0003 0.0014
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0084 0.1767
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0042 0.0081 0.0622
Plasmodium vivax acetyl-CoA synthetase, putative 0.0042 0.0081 0.0683
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.0025 0.0426
Brugia malayi nuclear receptor NHR-88 0.0034 0.0055 0.0457
Toxoplasma gondii pyruvate kinase PyKII 0.0051 0.0107 0.0351
Trypanosoma cruzi pyruvate kinase 2, putative 0.0099 0.0253 0.2301
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0055 0.0426
Echinococcus granulosus dnaJ subfamily B 0.0421 0.1225 0.6143
Onchocerca volvulus Pyruvate kinase homolog 0.0099 0.0253 0.2353
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0025 0.0157
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0042 0.0081 0.0683
Echinococcus granulosus protein jagged 2 0.0016 0.0003 0.0009
Leishmania major cytochrome p450-like protein 0.0024 0.0025 0.0152
Brugia malayi Trypsin family protein 0.0084 0.0209 0.177
Schistosoma mansoni pyruvate kinase 0.0051 0.0107 0.0839
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0055 0.0457
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0055 0.0054
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Schistosoma mansoni notch 0.0016 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0015
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Schistosoma mansoni topbp1 0.003 0.0043 0.0333
Schistosoma mansoni cercarial elastase (S01 family) 0.0084 0.0209 0.1647
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0081 0.068
Loa Loa (eye worm) PAN domain-containing protein 0.0107 0.0277 0.2353
Brugia malayi Patched family protein 0.0024 0.0028 0.0223
Schistosoma mansoni hypothetical protein 0.0167 0.0458 0.3627
Brugia malayi Niemann-Pick C1 protein precursor 0.0404 0.1173 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0113 0.0294 0.0293
Schistosoma mansoni DNA ligase IV 0.003 0.0043 0.0333
Onchocerca volvulus Neurogenic locus notch homolog 0.0016 0.0003 0.0017
Loa Loa (eye worm) hypothetical protein 0.0034 0.0055 0.0457
Brugia malayi Patched related family protein 4 0.0024 0.0028 0.0223
Mycobacterium ulcerans acetyl-CoA synthetase 0.0042 0.0081 0.191
Loa Loa (eye worm) hypothetical protein 0.0041 0.0079 0.0657
Echinococcus granulosus chromobox protein 1 0.0072 0.017 0.0847
Schistosoma mansoni hypothetical protein 0.0183 0.0508 0.4021
Echinococcus granulosus slit 2 protein 0.0016 0.0003 0.0009
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0009 0.0184
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0055 0.0054
Brugia malayi EGF-like domain containing protein 0.0016 0.0003 0.0015
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0055 0.0269
Toxoplasma gondii PAN domain-containing protein 0.0107 0.0277 0.0925
Echinococcus multilocularis notch 0.0016 0.0003 0.0002
Schistosoma mansoni cpg binding protein 0.0031 0.0048 0.0369
Onchocerca volvulus 0.0042 0.0081 0.0746
Entamoeba histolytica hypothetical protein 0.0113 0.0294 0.2449
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.003 0.0043 0.0358
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Brugia malayi AMP-binding enzyme family protein 0.0144 0.0388 0.3298
Plasmodium vivax replication factor C subunit 1, putative 0.003 0.0043 0.0327
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0055 0.0269
Onchocerca volvulus 0.0042 0.0081 0.0746
Echinococcus multilocularis enteropeptidase 0.0084 0.0209 0.0207
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0081 0.191
Leishmania major hypothetical protein, conserved 0.0206 0.0577 0.5355
Brugia malayi hypothetical protein 0.0018 0.0007 0.0049
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Loa Loa (eye worm) hypothetical protein 0.0368 0.1067 0.9091
Onchocerca volvulus 0.0107 0.0277 0.2582
Schistosoma mansoni hypothetical protein 0.0183 0.0508 0.4021
Brugia malayi Muscle positioning protein 4 0.0016 0.0003 0.0015
Schistosoma mansoni notch 0.0016 0.0003 0.0014
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0055 0.0426
Brugia malayi EGF-like domain containing protein 0.0016 0.0003 0.0015
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Giardia lamblia Replication factor C, subunit 1 0.003 0.0043 0.1609
Echinococcus granulosus tissue type plasminogen activator 0.0369 0.1069 0.536
Loa Loa (eye worm) hypothetical protein 0.0034 0.0055 0.0457
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0009 0.0196
Echinococcus multilocularis chromobox protein 1 0.0072 0.017 0.0169
Trichomonas vaginalis chromobox protein, putative 0.0072 0.017 0.3569
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0025 0.044
Mycobacterium leprae Probable pyruvate kinase PykA 0.0099 0.0253 0.6075
Onchocerca volvulus 0.0016 0.0003 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0043 0.0911
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0055 0.0426
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.0079 0.0657
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0081 0.068
Schistosoma mansoni cell polarity protein 0.0016 0.0003 0.0014
Echinococcus multilocularis neurogenic locus notch protein 0.0016 0.0003 0.0002
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0042 0.0081 0.1276
Loa Loa (eye worm) hypothetical protein 0.0084 0.0209 0.177
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0042 0.0081 0.0683
Echinococcus granulosus nibrin 0.003 0.0043 0.021
Echinococcus multilocularis Niemann Pick C1 protein 0.0404 0.1173 0.1172
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0055 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0055 0.0457
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0055 0.0426
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.017 0.144
Onchocerca volvulus 0.0047 0.0095 0.0875
Brugia malayi CXXC zinc finger family protein 0.003 0.0043 0.0354
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0055 0.0269
Schistosoma mansoni cercarial elastase (S01 family) 0.0084 0.0209 0.1647
Onchocerca volvulus 0.0042 0.0081 0.0746
Brugia malayi Heterochromatin protein 1 0.0072 0.017 0.144
Onchocerca volvulus 0.0369 0.1069 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0099 0.0253 0.2144
Loa Loa (eye worm) pyruvate kinase 0.0099 0.0253 0.2144
Onchocerca volvulus 0.0107 0.0277 0.2582
Onchocerca volvulus 0.0024 0.0028 0.0245
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Echinococcus multilocularis protein jagged 2 0.0016 0.0003 0.0002
Plasmodium vivax acyl-CoA synthetase, putative 0.0107 0.0278 0.2541
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0009 0.0036
Schistosoma mansoni hypothetical protein 0.0016 0.0003 0.0014
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0032 0.022
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0142 0.3525
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0055 0.0457
Echinococcus multilocularis chromobox protein 1 0.0072 0.017 0.0169
Schistosoma mansoni cercarial elastase (S01 family) 0.0084 0.0209 0.1647
Brugia malayi protein C24B5.3 0.0024 0.0028 0.0223
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0084 0.0209 0.1647
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0007 0.0049
Echinococcus multilocularis replication factor c subunit 1 0.003 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0084 0.0209 0.177
Echinococcus granulosus expressed protein 0.0049 0.0101 0.0498
Toxoplasma gondii PAN domain-containing protein 0.0996 0.2965 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0055 0.0426
Loa Loa (eye worm) hypothetical protein 0.0042 0.0081 0.068
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0007 0.0046
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0049 0.0101 0.0847
Schistosoma mansoni notch 0.0016 0.0003 0.0014
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0025 0.02
Loa Loa (eye worm) hypothetical protein 0.0107 0.0277 0.2353
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0055 0.0457
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0042 0.0081 0.191
Loa Loa (eye worm) hypothetical protein 0.0404 0.1173 1
Brugia malayi hypothetical protein 0.0026 0.0032 0.026
Brugia malayi Patched family protein 0.0024 0.0028 0.0223
Trypanosoma cruzi FHA domain containing protein, putative 0.003 0.0043 0.0327
Loa Loa (eye worm) hypothetical protein 0.0368 0.1067 0.9091
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0009 0.0196
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0007 0.0006
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0003 0.0015
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0432 0.1261 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0055 0.0457
Brugia malayi PAN domain containing protein 0.0107 0.0277 0.2353
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.003 0.0043 0.0327
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0057 0.0473
Echinococcus granulosus glycoprotein Antigen 5 0.0084 0.0209 0.1041
Brugia malayi Patched protein homolog 1 0.0024 0.0028 0.0223
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0055 0.0457
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0233 0.184
Brugia malayi hypothetical protein 0.0037 0.0066 0.0554
Loa Loa (eye worm) hypothetical protein 0.0107 0.0278 0.2361
Trichomonas vaginalis antibiotic synthetase, putative 0.0042 0.0081 0.1702
Toxoplasma gondii ATPase, AAA family protein 0.003 0.0043 0.0136
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0015
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0055 0.0054
Brugia malayi hypothetical protein 0.0024 0.0028 0.0223
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0084 0.0209 0.177
Onchocerca volvulus Protein patched homolog 0.0024 0.0028 0.0245
Brugia malayi PAN domain containing protein 0.0107 0.0277 0.2353
Brugia malayi hypothetical protein 0.0084 0.0209 0.177
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0049 0.0101 0.0847
Brugia malayi Patched family protein 0.0024 0.0028 0.0223
Echinococcus granulosus Niemann Pick C1 protein 0.0577 0.1697 0.851
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0055 0.0269
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Plasmodium vivax pyruvate kinase, putative 0.0099 0.0253 0.2301
Onchocerca volvulus 0.0107 0.0277 0.2582
Echinococcus granulosus pyruvate kinase 0.0051 0.0107 0.053
Echinococcus granulosus sterol regulatory element binding protein 0.0173 0.0477 0.2387
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0032 0.022
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0025 0.02
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0009 0.0196
Schistosoma mansoni hypothetical protein 0.0016 0.0003 0.0014
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0055 0.0426
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0042 0.0081 0.191
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0025 0.044
Onchocerca volvulus 0.003 0.0043 0.0393
Echinococcus multilocularis pyruvate kinase 0.0078 0.019 0.0188
Plasmodium falciparum acyl-CoA synthetase 0.0107 0.0278 0.2541
Leishmania major hypothetical protein, conserved 0.0369 0.1069 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.003 0.0043 0.0911
Brugia malayi ecdysteroid receptor 0.0034 0.0055 0.0457
Onchocerca volvulus 0.0107 0.0277 0.2582
Loa Loa (eye worm) hypothetical protein 0.0144 0.0388 0.3298
Schistosoma mansoni patched 1 0.0173 0.0477 0.3777
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0025 0.0533
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0042 0.0081 0.1096
Schistosoma mansoni cercarial elastase (S01 family) 0.0084 0.0209 0.1647
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0015
Trichomonas vaginalis pyruvate kinase, putative 0.0099 0.0253 0.5298
Loa Loa (eye worm) hypothetical protein 0.0212 0.0595 0.5063
Schistosoma mansoni hypothetical protein 0.0047 0.0095 0.0742
Schistosoma mansoni hypothetical protein 0.0016 0.0003 0.0014
Trypanosoma brucei hypothetical protein, conserved 0.0206 0.0577 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0055 0.0457
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.0079 0.0657
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0055 0.0457
Brugia malayi PAN domain containing protein 0.0107 0.0277 0.2353
Brugia malayi Patched family protein 0.0024 0.0028 0.0223
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0015
Loa Loa (eye worm) hypothetical protein 0.0369 0.1069 0.9113
Schistosoma mansoni notch 0.0016 0.0003 0.0014
Brugia malayi hypothetical protein 0.0024 0.0028 0.0223
Echinococcus multilocularis transmembrane protease serine 3 0.0084 0.0209 0.0207
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0055 0.0502
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0025 0.0152
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0081 0.191
Echinococcus granulosus pyruvate kinase 0.0051 0.0107 0.053
Plasmodium vivax patched family protein, putative 0.0024 0.0028 0.0178
Loa Loa (eye worm) hypothetical protein 0.0084 0.0209 0.177
Loa Loa (eye worm) hypothetical protein 0.003 0.0043 0.0358
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0142 0.3525
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0144 0.0388 1
Brugia malayi hypothetical protein 0.0024 0.0028 0.0223
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0055 0.0457
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.0081 0.191
Loa Loa (eye worm) hypothetical protein 0.0084 0.0209 0.177
Echinococcus multilocularis neural cadherin 0.0016 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0015
Brugia malayi protein C24B5.3 0.0024 0.0028 0.0223
Schistosoma mansoni cpg binding protein 0.003 0.0043 0.0329
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0102 0.0261 0.6638
Brugia malayi Trypsin family protein 0.0084 0.0209 0.177
Onchocerca volvulus 0.0107 0.0277 0.2582
Loa Loa (eye worm) pyruvate kinase 0.0021 0.0017 0.0129
Brugia malayi EGF-like domain containing protein 0.0016 0.0003 0.0015
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0055 0.0269
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0107 0.0277 0.0925
Schistosoma mansoni niemann-pick C1 (NPC1) 0.041 0.1192 0.9456
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0009 0.0196
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0042 0.0081 0.0683
Onchocerca volvulus Putative cubilin 0.0016 0.0003 0.0017
Loa Loa (eye worm) TK/ROR protein kinase 0.0369 0.1069 0.9113
Echinococcus multilocularis protein jagged 1 0.0016 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.003 0.0043 0.0358
Onchocerca volvulus 0.0024 0.0028 0.0245
Schistosoma mansoni topbp1 0.003 0.0043 0.0333
Loa Loa (eye worm) hypothetical protein 0.0042 0.0081 0.068
Brugia malayi hypothetical protein 0.003 0.0043 0.0358
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0049 0.0101 0.0788
Schistosoma mansoni pyruvate kinase 0.0099 0.0253 0.1995
Entamoeba histolytica hypothetical protein 0.003 0.0043 0.0298
Schistosoma mansoni chromosome transmission fidelity factor 0.003 0.0043 0.0333
Mycobacterium ulcerans pyruvate kinase 0.0099 0.0253 0.6434
Schistosoma mansoni coup transcription factor 0.0034 0.0055 0.0426
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0025 0.044
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.0079 0.0077
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0042 0.0081 0.191
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0009 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0075 0.1574
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0312 0.2651
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0015
Onchocerca volvulus Pyruvate kinase homolog 0.0099 0.0253 0.2353
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0049
Echinococcus multilocularis pyruvate kinase 0.0099 0.0253 0.0251
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0055 0.0269
Toxoplasma gondii exonuclease III APE 0.0018 0.0009 0.0018
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0042 0.0081 0.068
Onchocerca volvulus 0.0084 0.0209 0.1943
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0015
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0042 0.0081 0.008
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0032 0.022
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0081 0.191
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Entamoeba histolytica hypothetical protein 0.0113 0.0294 0.2449
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.0577 0.5355
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0084 0.0209 0.1647
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.003 0.0043 0.0911
Schistosoma mansoni ap endonuclease 0.0018 0.0009 0.0057
Schistosoma mansoni septate junction protein 0.0016 0.0003 0.0014
Brugia malayi PAN domain containing protein 0.0107 0.0277 0.2353
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0049 0.0101 0.0868
Loa Loa (eye worm) PAN domain-containing protein 0.0107 0.0277 0.2353
Echinococcus granulosus fibropellin Ia 0.0016 0.0003 0.0009
Brugia malayi chromobox protein homolog 3 0.004 0.0075 0.0628
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0312 0.2651
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0055 0.0054
Echinococcus granulosus chromobox protein 1 0.0072 0.017 0.0847
Mycobacterium ulcerans hypothetical protein 0.0084 0.0209 0.5279
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0233 0.0232
Toxoplasma gondii PAN domain-containing protein 0.0107 0.0277 0.0925
Loa Loa (eye worm) hypothetical protein 0.0107 0.0277 0.2353
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.003 0.0043 0.0611
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0009 0.0219
Toxoplasma gondii kringle domain-containing protein 0.0369 0.1069 0.3599
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.0646 0.0645
Brugia malayi EGF-like domain containing protein 0.0016 0.0003 0.0015
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0081 0.068
Brugia malayi GCC2 and GCC3 family protein 0.0016 0.0003 0.0015
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0043 0.0327
Trypanosoma cruzi pyruvate kinase 2, putative 0.0099 0.0253 0.2301
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0009 0.0196
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0084 0.0209 0.1647
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0016 0.0003 0.0015
Schistosoma mansoni hypothetical protein 0.002 0.0014 0.0098
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0043 0.0327
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0075 0.0689
Loa Loa (eye worm) patched family protein 0.0024 0.0028 0.0223
Brugia malayi Patched family protein 0.0024 0.0028 0.0223
Schistosoma mansoni transcription factor LCR-F1 0.0113 0.0294 0.2323
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.004 0.0831
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0009 0.0062
Echinococcus multilocularis fibropellin Ia 0.0016 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.0016 0.0003 0.0014
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0042 0.0081 0.191
Brugia malayi Patched related family protein 10 0.0024 0.0028 0.0223
Loa Loa (eye worm) hypothetical protein 0.0069 0.0162 0.1372
Brugia malayi Patched family protein 0.0024 0.0028 0.0223
Echinococcus granulosus enteropeptidase 0.0084 0.0209 0.1041
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0144 0.0388 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Echinococcus multilocularis neurogenic locus notch protein 0.0016 0.0003 0.0002
Brugia malayi Delta serrate ligand family protein 0.0016 0.0003 0.0015
Echinococcus multilocularis geminin 0.0183 0.0508 0.0506
Loa Loa (eye worm) hypothetical protein 0.003 0.0043 0.0358
Brugia malayi Cytochrome P450 family protein 0.0034 0.0057 0.0473
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0055 0.0457
Brugia malayi pyruvate kinase 0.0021 0.0017 0.0129
Loa Loa (eye worm) hypothetical protein 0.0034 0.0055 0.0457
Loa Loa (eye worm) hypothetical protein 0.0034 0.0055 0.0457
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0025 0.0152
Loa Loa (eye worm) hypothetical protein 0.0107 0.0278 0.2361
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.0081 0.191
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0015
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0042 0.0081 0.191
Loa Loa (eye worm) hypothetical protein 0.0229 0.0646 0.5501
Brugia malayi Patched family protein 0.0024 0.0028 0.0223
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0055 0.0457
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0009 0.0196
Toxoplasma gondii propionate-CoA ligase 0.0042 0.0081 0.0263
Echinococcus multilocularis pyruvate kinase 0.0051 0.0107 0.0106
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0144 0.0388 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0032 0.022
Schistosoma mansoni cercarial elastase (S01 family) 0.0084 0.0209 0.1647
Echinococcus multilocularis pyruvate kinase 0.0051 0.0107 0.0106
Mycobacterium tuberculosis Conserved protein 0.0024 0.0025 0.044
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0113 0.0294 0.1468
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0055 0.0054
Toxoplasma gondii patched family protein 0.0024 0.0028 0.0082
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0049
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0084 0.0775
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0055 0.0457
Brugia malayi Patched related family protein 12 0.0024 0.0028 0.0223
Loa Loa (eye worm) notch protein 0.0016 0.0003 0.0015
Leishmania major 4-coumarate:coa ligase-like protein 0.0144 0.0388 0.3576
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0042 0.0081 0.0263
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0032 0.022
Onchocerca volvulus Slit protein homolog 0.0016 0.0003 0.0017
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0042 0.0081 0.068
Brugia malayi pyruvate kinase, muscle isozyme 0.0021 0.0017 0.0129
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0099 0.0253 0.6434
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0015
Loa Loa (eye worm) hypothetical protein 0.0107 0.0278 0.2361
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Loa Loa (eye worm) hypothetical protein 0.0034 0.0055 0.0457
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0173 0.0477 0.4058
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0107 0.0278 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0577 0.1697 0.1696
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0007 0.0049
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0055 0.0457
Schistosoma mansoni notch 0.0016 0.0003 0.0014
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0016 0.0003 0.0017
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Echinococcus granulosus neurogenic locus notch protein 4 0.0016 0.0003 0.0009
Loa Loa (eye worm) pyruvate kinase 0.0099 0.0253 0.2144
Mycobacterium ulcerans hypothetical protein 0.0144 0.0388 1
Onchocerca volvulus 0.0099 0.0252 0.2348
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0055 0.0269
Echinococcus multilocularis pyruvate kinase 0.0099 0.0253 0.0251
Schistosoma mansoni hypothetical protein 0.0167 0.0458 0.3627
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0015
Entamoeba histolytica hypothetical protein 0.0113 0.0294 0.2449
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0142 0.3525
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Toxoplasma gondii microneme protein MIC17B 0.0107 0.0277 0.0925
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0055 0.0426
Echinococcus multilocularis Mastin 0.0084 0.0209 0.0207
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0003 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0055 0.0457
Echinococcus granulosus protein jagged 1 0.0016 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.004 0.0075 0.0628
Brugia malayi Cytochrome P450 family protein 0.0024 0.0025 0.02
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0025 0.0024
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0081 0.191
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0055 0.0426
Onchocerca volvulus 0.0107 0.0277 0.2582
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0123 0.0404
Brugia malayi Patched family protein 0.0024 0.0028 0.0223
Brugia malayi Trypsin-like protease protein 5 0.0084 0.0209 0.177
Echinococcus multilocularis expressed protein 0.0049 0.0101 0.0099
Onchocerca volvulus 0.0016 0.0003 0.0017
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0042 0.0081 0.191
Loa Loa (eye worm) hypothetical protein 0.0034 0.0055 0.0457
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0081 0.191
Trypanosoma brucei pyruvate kinase 1 0.0099 0.0253 0.4296
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0055 0.0457
Onchocerca volvulus 0.0084 0.0209 0.1943
Toxoplasma gondii TIM10 family protein, putative 0.0049 0.0101 0.0329
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0055 0.0457
Schistosoma mansoni survival motor neuron protein 0.0047 0.0095 0.0742
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0043 0.0911
Schistosoma mansoni hypothetical protein 0.0167 0.0458 0.3627
Onchocerca volvulus 0.0107 0.0277 0.2582
Echinococcus granulosus pyruvate kinase 0.0099 0.0253 0.1261
Loa Loa (eye worm) patched family protein 0.0024 0.0028 0.0223
Loa Loa (eye worm) PAN domain-containing protein 0.0107 0.0277 0.2353
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0142 0.1119
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0025 0.0157
Toxoplasma gondii PAN domain-containing protein 0.0996 0.2965 1
Plasmodium falciparum pyruvate kinase 2 0.0051 0.0107 0.0928
Brugia malayi hypothetical protein 0.0037 0.0066 0.0554
Onchocerca volvulus 0.0024 0.0028 0.0245
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0049
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0055 0.0426
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.0081 0.191
Toxoplasma gondii pyruvate kinase PyK1 0.0099 0.0253 0.0842
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0055 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0369 0.1069 1
Schistosoma mansoni hypothetical protein 0.0084 0.0209 0.1647
Loa Loa (eye worm) patched family protein 0.0024 0.0028 0.0223
Brugia malayi Cytochrome P450 family protein 0.0024 0.0025 0.02
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.0081 0.191
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0102 0.0261 0.6638
Echinococcus granulosus neurogenic locus notch protein 0.0016 0.0003 0.0009
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.003 0.0043 0.0136
Loa Loa (eye worm) hypothetical protein 0.0144 0.0388 0.3298
Onchocerca volvulus 0.0024 0.0028 0.0245
Echinococcus granulosus Niemann Pick C1 protein 0.0404 0.1173 0.5882
Loa Loa (eye worm) hypothetical protein 0.0107 0.0278 0.2361
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.003 0.0043 0.0911
Plasmodium falciparum pyruvate kinase 0.0099 0.0253 0.2301
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0081 0.191
Loa Loa (eye worm) oxidoreductase 0.0042 0.0081 0.068
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0015
Schistosoma mansoni notch 0.0016 0.0003 0.0014
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0233 0.0232
Leishmania major acetyl-CoA synthetase, putative 0.0042 0.0081 0.0683
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0055 0.0502
Loa Loa (eye worm) hypothetical protein 0.0034 0.0055 0.0457
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0081 0.191
Mycobacterium ulcerans hypothetical protein 0.0024 0.0025 0.044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0144 0.0388 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0055 0.0269
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Schistosoma mansoni cercarial elastase (S01 family) 0.0084 0.0209 0.1647
Echinococcus granulosus expressed conserved protein 0.0379 0.1099 0.5511
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0043 0.0911
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0042 0.0081 0.1096
Onchocerca volvulus Protein patched homolog 0.0024 0.0028 0.0245
Brugia malayi Patched family protein 0.0024 0.0028 0.0223
Schistosoma mansoni hypothetical protein 0.0421 0.1225 0.9718
Echinococcus granulosus pyruvate kinase 0.0051 0.0107 0.053
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0003 0.0015
Brugia malayi PAN domain containing protein 0.0107 0.0277 0.2353
Toxoplasma gondii microneme protein, putative 0.0107 0.0277 0.0925
Toxoplasma gondii PAN domain-containing protein 0.0107 0.0277 0.0925
Trichomonas vaginalis antibiotic synthetase, putative 0.0042 0.0081 0.1702
Schistosoma mansoni pyruvate kinase 0.0099 0.0253 0.1995
Brugia malayi Pyruvate kinase, M2 isozyme 0.0099 0.0253 0.2144
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0142 0.0707
Mycobacterium ulcerans hypothetical protein 0.0024 0.0025 0.044
Brugia malayi Patched family protein 0.0024 0.0028 0.0223
Echinococcus multilocularis tissue type plasminogen activator 0.0369 0.1069 0.1068
Onchocerca volvulus 0.003 0.0043 0.0388
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0042 0.0081 0.191
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0107 0.0278 0.7105
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0144 0.0388 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0144 0.0388 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0084 0.0209 0.1647
Onchocerca volvulus 0.0016 0.0003 0.0017
Toxoplasma gondii hypothetical protein 0.0107 0.0277 0.0925
Onchocerca volvulus 0.0024 0.0028 0.0245
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0233 0.184
Brugia malayi hypothetical protein 0.0018 0.0007 0.0049
Trichomonas vaginalis chromobox protein, putative 0.0072 0.017 0.3569
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Brugia malayi DKFZp564C0469 protein 0.003 0.0043 0.0358
Loa Loa (eye worm) patched family protein 0.0024 0.0028 0.0223
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0369 0.1069 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0015
Loa Loa (eye worm) hypothetical protein 0.003 0.0043 0.0358
Schistosoma mansoni hypothetical protein 0.0167 0.0458 0.3627
Brugia malayi Patched family protein 0.0024 0.0028 0.0223
Echinococcus granulosus geminin 0.0183 0.0508 0.2541
Onchocerca volvulus 0.0107 0.0277 0.2582
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.0477 1
Toxoplasma gondii PAN domain-containing protein 0.0107 0.0277 0.0925
Brugia malayi hypothetical protein 0.003 0.0043 0.0358
Loa Loa (eye worm) pyruvate kinase-PB 0.0069 0.0162 0.1372
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0055 0.0457
Brugia malayi notch-like transmembrane receptor 0.0016 0.0003 0.0015
Echinococcus multilocularis slit 2 protein 0.0016 0.0003 0.0002
Brugia malayi nuclear receptor RXR 0.0018 0.0007 0.0049
Onchocerca volvulus 0.0034 0.0055 0.0502
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0055 0.0457
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0025 0.0285
Loa Loa (eye worm) hypothetical protein 0.0107 0.0277 0.2353
Toxoplasma gondii microneme protein MIC17C 0.0107 0.0277 0.0925
Echinococcus multilocularis nibrin 0.003 0.0043 0.0042
Schistosoma mansoni acetyl-CoA synthetase 0.0042 0.0081 0.0633
Brugia malayi CHE-14 protein 0.0173 0.0477 0.4058
Brugia malayi Patched family protein 0.0024 0.0028 0.0223
Schistosoma mansoni cercarial elastase (S01 family) 0.0084 0.0209 0.1647
Loa Loa (eye worm) patched family protein 0.0024 0.0028 0.0223
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0142 0.1261
Echinococcus multilocularis glycoprotein Antigen 5 0.0084 0.0209 0.0207
Echinococcus multilocularis neurogenic locus protein delta 0.0016 0.0003 0.0002
Schistosoma mansoni cpg binding protein 0.0031 0.0048 0.0369
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0009 0.0062
Echinococcus multilocularis sterol regulatory element binding protein 0.0173 0.0477 0.0476
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0042 0.0081 0.0263
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0055 0.0457
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0015
Brugia malayi Patched family protein 0.0024 0.0028 0.0223
Echinococcus multilocularis tumor protein p63 0.0675 0.1994 0.1993
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0042 0.0081 0.1276
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0015
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.003 0.0043 0.0911
Onchocerca volvulus 0.0031 0.0049 0.0443
Echinococcus granulosus neurogenic locus protein delta 0.0016 0.0003 0.0009
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.003 0.0043 0.0298
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0142 0.0141
Loa Loa (eye worm) hypothetical protein 0.0173 0.0477 0.4058
Giardia lamblia Pyruvate kinase 0.0099 0.0253 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0368 0.1067 0.846
Toxoplasma gondii subtilisin SUB12 0.0107 0.0277 0.0925
Leishmania major pyruvate kinase 0.0099 0.0253 0.2301
Toxoplasma gondii microneme protein MIC4 0.0107 0.0277 0.0925
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0042 0.0081 0.191
Loa Loa (eye worm) hypothetical protein 0.0107 0.0278 0.2361
Brugia malayi hypothetical protein 0.0024 0.0028 0.0223
Onchocerca volvulus 0.0144 0.0388 0.3619
Echinococcus multilocularis neurogenic locus protein delta 0.0016 0.0003 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.0577 0.5355
Schistosoma mansoni slit 0.0016 0.0003 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0144 0.0388 0.3298
Trichomonas vaginalis pyruvate kinase, putative 0.0099 0.0253 0.5298
Entamoeba histolytica pyruvate kinase, putative 0.0069 0.0162 0.1318
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0142 0.1119
Brugia malayi Patched family protein 0.0024 0.0028 0.0223
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0055 0.0054
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0009 0.0184
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0084 0.0209 0.1041
Echinococcus multilocularis protein dispatched 1 0.0198 0.0551 0.055
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0042 0.0081 0.04
Echinococcus multilocularis fat cadherin tumor suppressor 0.0016 0.0003 0.0002
Plasmodium falciparum cysteine repeat modular protein 1 0.0369 0.1069 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0007 0.0049
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0252 0.1991
Loa Loa (eye worm) hypothetical protein 0.003 0.0043 0.0358
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0015
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0081 0.068
Leishmania major pyruvate kinase 0.0099 0.0253 0.2301
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0055 0.0426
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0107 0.0278 0.7105
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0084 0.0209 0.1041
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Brugia malayi PAN domain containing protein 0.0107 0.0277 0.2353
Loa Loa (eye worm) hypothetical protein 0.0084 0.0209 0.177
Entamoeba histolytica acyl-CoA synthetase, putative 0.0144 0.0388 0.3257
Onchocerca volvulus 0.0107 0.0277 0.2582
Echinococcus granulosus delta-like protein 1 0.0016 0.0003 0.0009
Brugia malayi Myosin head containing protein 0.0024 0.0028 0.0223
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0042 0.0081 0.191
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0042 0.0081 0.191
Leishmania major 4-coumarate:coa ligase-like protein 0.0144 0.0388 0.3576
Echinococcus granulosus neurogenic locus notch protein 0.0016 0.0003 0.0009
Chlamydia trachomatis pyruvate kinase 0.0099 0.0253 0.8916
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.026
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0015
Echinococcus granulosus cpg binding protein 0.0031 0.0048 0.0234
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0025 0.044
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Brugia malayi steroid hormone receptor 0.0034 0.0055 0.0457
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0007 0.0046
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0081 0.191
Toxoplasma gondii hypothetical protein 0.0024 0.0028 0.0082
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0055 0.0457
Brugia malayi hypothetical protein 0.0113 0.0294 0.2496
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0042 0.0081 0.191
Brugia malayi Cadherin domain containing protein 0.0016 0.0003 0.0015
Loa Loa (eye worm) PAN domain-containing protein 0.0107 0.0277 0.2353
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0055 0.0269
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0075 0.1574
Brugia malayi Trypsin family protein 0.0084 0.0209 0.177
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Plasmodium falciparum lipid/sterol:H+ symporter 0.0024 0.0028 0.0178
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0095 0.0797
Leishmania major hypothetical protein, conserved 0.0026 0.0032 0.022
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0084 0.0209 0.1647
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0084 0.0209 0.0207
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0042 0.0081 0.191
Loa Loa (eye worm) hypothetical protein 0.003 0.0043 0.0358
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0233 0.184
Schistosoma mansoni chromobox protein 0.0072 0.017 0.134
Brugia malayi topoisomerase 0.003 0.0043 0.0358
Schistosoma mansoni hypothetical protein 0.0016 0.0003 0.0014
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0144 0.0388 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0223
Brugia malayi nuclear hormone receptor 0.0034 0.0055 0.0457
Onchocerca volvulus 0.0016 0.0003 0.0017
Onchocerca volvulus 0.0084 0.0209 0.1943
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0016 0.0003 0.0014
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0007 0.0029
Brugia malayi EGF-like domain containing protein 0.0016 0.0003 0.0015
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0036 0.0063 0.1443
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0032 0.041
Loa Loa (eye worm) pyruvate kinase 0.0099 0.0253 0.2144
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0233 0.1163
Schistosoma mansoni chromobox protein 0.0072 0.017 0.134
Echinococcus granulosus protein jagged 1 0.0016 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0015
Onchocerca volvulus 0.0368 0.1067 0.9976
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0102 0.0261 0.6638
Brugia malayi Protein kinase domain containing protein 0.0369 0.1069 0.9113
Toxoplasma gondii patched family protein 0.0024 0.0028 0.0082
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0055 0.0054
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0041 0.0079 0.0254
Brugia malayi PAN domain containing protein 0.0107 0.0277 0.2353
Brugia malayi PAN domain containing protein 0.0107 0.0277 0.2353
Plasmodium falciparum replication factor C subunit 1, putative 0.003 0.0043 0.0327
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0404
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0055 0.0457
Schistosoma mansoni hypothetical protein 0.0084 0.0209 0.1647
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0233 0.1977
Brugia malayi Trypsin family protein 0.0368 0.1067 0.9091
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0368 0.1067 0.846
Brugia malayi AMP-binding enzyme family protein 0.0144 0.0388 0.3298
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0043 0.0911
Toxoplasma gondii microneme protein MIC17A 0.0107 0.0277 0.0925
Loa Loa (eye worm) hypothetical protein 0.0099 0.0253 0.2144
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.004 0.0831
Brugia malayi MH2 domain containing protein 0.0119 0.0312 0.2651
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0142 0.047
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0144 0.0388 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0042 0.0081 0.191
Onchocerca volvulus 0.0024 0.0028 0.0245
Schistosoma mansoni hypothetical protein 0.0016 0.0003 0.0014
Echinococcus multilocularis dnaJ subfamily B 0.0421 0.1225 0.1224
Echinococcus granulosus notch 0.0016 0.0003 0.0009
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0025 0.0157
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0055 0.0457
Brugia malayi Patched family protein 0.0024 0.0028 0.0223

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 52 nM In vitro binding affinity towards human peroxisome proliferator activated receptor delta (PPAR delta) ChEMBL. 12617924
Ki (binding) = 52 nM In vitro binding affinity towards human peroxisome proliferator activated receptor delta (PPAR delta) ChEMBL. 12617924
Ki (binding) = 115 nM In vitro binding affinity towards human peroxisome proliferator activated receptor gamma (PPAR gamma) ChEMBL. 12617924
Ki (binding) = 115 nM In vitro binding affinity towards human peroxisome proliferator activated receptor gamma (PPAR gamma) ChEMBL. 12617924
Ki (binding) = 329 nM In vitro binding affinity towards human peroxisome proliferator activated receptor alpha (PPAR alpha) ChEMBL. 12617924
Ki (binding) = 329 nM In vitro binding affinity towards human peroxisome proliferator activated receptor alpha (PPAR alpha) ChEMBL. 12617924

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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