Detailed information for compound 306980

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 526.414 | Formula: C26H25Cl2N5O3
  • H donors: 3 H acceptors: 4 LogP: 3.87 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: NC(=O)C1CCN(CC1)Cc1ccc(cc1)C(=O)Nc1ccc(cc1C(=O)Nc1ccc(cn1)Cl)Cl
  • InChi: 1S/C26H25Cl2N5O3/c27-19-5-7-22(21(13-19)26(36)32-23-8-6-20(28)14-30-23)31-25(35)18-3-1-16(2-4-18)15-33-11-9-17(10-12-33)24(29)34/h1-8,13-14,17H,9-12,15H2,(H2,29,34)(H,31,35)(H,30,32,36)
  • InChiKey: VFHCWZOOWGZTFF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor X Starlite/ChEMBL References
Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) Starlite/ChEMBL References
Homo sapiens protease, serine, 1 (trypsin 1) Starlite/ChEMBL References
Homo sapiens plasminogen activator, tissue Starlite/ChEMBL References
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References
Homo sapiens plasminogen Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Echinococcus multilocularis Mastin Get druggable targets OG5_136757 All targets in OG5_136757
Brugia malayi Trypsin family protein Get druggable targets OG5_126639 All targets in OG5_126639
Echinococcus multilocularis enteropeptidase Get druggable targets OG5_136757 All targets in OG5_136757
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_136757 All targets in OG5_136757
Echinococcus multilocularis glycoprotein Antigen 5 Get druggable targets OG5_136757 All targets in OG5_136757
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Echinococcus granulosus Mastin Get druggable targets OG5_136757 All targets in OG5_136757
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K01346 pancreatic elastase II [EC3.4.21.71], putative Get druggable targets OG5_136757 All targets in OG5_136757
Echinococcus granulosus enteropeptidase Get druggable targets OG5_136757 All targets in OG5_136757
Echinococcus granulosus glycoprotein Antigen 5 Get druggable targets OG5_136757 All targets in OG5_136757
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Trypsin family protein protease, serine, 1 (trypsin 1) 247 aa 287 aa 21.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0048 0.0141
Loa Loa (eye worm) cysteine protease 0.0022 0.001 0.003
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0883 0.3414 1
Brugia malayi Fibulin-1 precursor 0.0032 0.0052 0.0151
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0219 0.0612
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0015 0.0044
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0146 0.05 0.1466
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.0106 0.0106
Giardia lamblia Rab geranylgeranyltransferase 0.0239 0.0871 0.2278
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0048 0.0141
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0239 0.0871 0.2528
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0219 0.4301
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.1092 0.3176
Onchocerca volvulus 0.0022 0.001 0.0075
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0883 0.3414 1
Brugia malayi Inositol-1 0.0079 0.0235 0.0689
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0368 0.138 0.4043
Echinococcus multilocularis Tolloid protein 1 0.0032 0.0052 0.0052
Entamoeba histolytica hypothetical protein 0.0035 0.0063 0.0154
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0048 0.0141
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0048 0.0048
Echinococcus granulosus Mastin 0.0069 0.0197 0.0576
Plasmodium falciparum plasmepsin X 0.0034 0.0059 0.0172
Entamoeba histolytica hypothetical protein 0.0035 0.0063 0.0154
Loa Loa (eye worm) hypothetical protein 0.0032 0.0052 0.0151
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0368 0.138 0.4043
Brugia malayi nuclear receptor NHR-88 0.0031 0.0048 0.0141
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0219 0.0708
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0368 0.138 0.4043
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.0106 0.0312
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0197 0.055
Brugia malayi Trypsin family protein 0.0023 0.0015 0.0044
Loa Loa (eye worm) oxidoreductase 0.0022 0.0011 0.0031
Giardia lamblia Prenyltransferase 0.0883 0.3414 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.0141
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.012 0.0323
Trypanosoma cruzi hypothetical protein, conserved 0.0368 0.138 0.4025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.1092 0.3176
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0132 0.0414
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0239 0.0871 0.0871
Giardia lamblia Fructose-bisphosphate aldolase 0.0295 0.1092 0.2948
Brugia malayi MH2 domain containing protein 0.0121 0.0401 0.1174
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0144 0.0494 0.1446
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0048 0.0141
Plasmodium falciparum plasmepsin VII 0.0034 0.0059 0.0172
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0883 0.3414 1
Brugia malayi nuclear hormone receptor 0.0031 0.0048 0.0141
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0048 0.0141
Brugia malayi Papain family cysteine protease containing protein 0.0022 0.001 0.003
Schistosoma mansoni patched 1 0.0133 0.0449 0.1315
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0031
Trichomonas vaginalis ral, putative 0.0594 0.2272 0.6645
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.1092 0.3176
Schistosoma mansoni hypothetical protein 0.0128 0.043 0.126
Echinococcus granulosus Niemann Pick C1 protein 0.0309 0.1147 0.336
Onchocerca volvulus 0.0034 0.0059 0.0425
Brugia malayi Pepsin A precursor 0.0034 0.0059 0.0172
Plasmodium vivax aspartyl proteinase, putative 0.0144 0.0494 0.1446
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.012 0.0323
Onchocerca volvulus Arrow homolog 0.0032 0.0052 0.0374
Loa Loa (eye worm) hypothetical protein 0.0133 0.0449 0.1315
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.012 0.012
Onchocerca volvulus 0.0022 0.0011 0.0076
Echinococcus granulosus glycoprotein Antigen 5 0.0069 0.0197 0.0576
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0643 0.2467 0.7227
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0377 0.1414 0.4124
Brugia malayi hypothetical protein 0.0035 0.0063 0.0184
Loa Loa (eye worm) aspartyl protease 6 0.0034 0.0059 0.0172
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0401 0.1174
Trypanosoma brucei lanosterol synthase 0.0765 0.2948 0.8631
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0492 0.1442
Trichomonas vaginalis inositol monophosphatase, putative 0.0079 0.0235 0.0661
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.001 0.003
Onchocerca volvulus 0.0022 0.001 0.0075
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.1092 0.3176
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0239 0.0871 0.0871
Onchocerca volvulus 0.0022 0.001 0.0075
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0015 0.0044
Trichomonas vaginalis ras-dva small GTPase, putative 0.0594 0.2272 0.6645
Echinococcus multilocularis cathepsin L cysteine protease 0.0022 0.001 0.001
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0074 0.0219 0.4301
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0146 0.05 0.1466
Schistosoma mansoni hypothetical protein 0.0046 0.0106 0.0312
Trichomonas vaginalis CMGC family protein kinase 0.005 0.012 0.0323
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0048 0.0349
Plasmodium falciparum plasmepsin I 0.0144 0.0494 0.1446
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0015 0.0044
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0032 0.0052 0.0151
Loa Loa (eye worm) ctsf protein 0.0022 0.001 0.003
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0056 0.0144 0.5
Brugia malayi Trypsin-like protease protein 5 0.0023 0.0015 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0048 0.0141
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0023 0.0015 0.0044
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0048 0.0048
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.007 0.0203 0.0654
Echinococcus multilocularis laminin 0.0032 0.0052 0.0052
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0219 0.0612
Schistosoma mansoni lamin 0.0026 0.0028 0.0082
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0167 0.0459
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0059 0.0172
Entamoeba histolytica Ras family GTPase 0.0594 0.2272 0.6645
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0048 0.0141
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0015 0.0044
Entamoeba histolytica hypothetical protein 0.0035 0.0063 0.0154
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0079 0.0235 0.0661
Echinococcus multilocularis inositol monophosphatase 1 0.0079 0.0235 0.0235
Brugia malayi MAP kinase sur-1 0.005 0.012 0.0353
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0167 0.0531
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0167 0.3225
Schistosoma mansoni hypothetical protein 0.01 0.0318 0.0932
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0063 0.0063
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0011 0.0031
Plasmodium falciparum cysteine repeat modular protein 1 0.0069 0.0197 0.0578
Onchocerca volvulus 0.0022 0.001 0.0075
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.0106 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0048 0.0141
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0368 0.138 0.4025
Onchocerca volvulus Cathepsin F homolog 0.0022 0.001 0.0075
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0239 0.0871 0.2551
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0368 0.138 0.4043
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0034 0.0059 0.0172
Loa Loa (eye worm) inositol-1 0.0079 0.0235 0.0689
Schistosoma mansoni serine/threonine protein kinase 0.005 0.012 0.0353
Echinococcus granulosus Protein patched homolog 1 0.0133 0.0449 0.1315
Loa Loa (eye worm) hypothetical protein 0.0069 0.0197 0.0578
Loa Loa (eye worm) hypothetical protein 0.0129 0.0436 0.1276
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0883 0.3414 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.0494 1
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0239 0.0871 0.2551
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0745 0.2871 0.8403
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.0141
Treponema pallidum fructose-bisphosphate aldolase 0.0295 0.1092 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0048 0.0141
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0048 0.0141
Trypanosoma brucei hypothetical protein, conserved 0.0368 0.138 0.4025
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0011 0.0031
Loa Loa (eye worm) hypothetical protein 0.0056 0.0144 0.0422
Onchocerca volvulus 0.0023 0.0015 0.0108
Toxoplasma gondii aspartyl protease ASP1 0.0144 0.0494 0.142
Onchocerca volvulus 0.0031 0.0048 0.0349
Trypanosoma cruzi hypothetical protein, conserved 0.0239 0.0871 0.2528
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0028 0.0082
Brugia malayi Trypsin family protein 0.0023 0.0015 0.0044
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0015 0.0044
Loa Loa (eye worm) hypothetical protein 0.0745 0.2871 0.8408
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0144 0.0494 0.1446
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0011 0.0031
Echinococcus multilocularis sterol regulatory element binding protein 0.0133 0.0449 0.0449
Trypanosoma cruzi protein farnesyltransferase, putative 0.0883 0.3414 1
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0167 0.0488
Echinococcus granulosus lamin dm0 0.0026 0.0028 0.0082
Echinococcus multilocularis cysteine protease 0.0022 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0239 0.0871 0.2551
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0239 0.0871 0.2551
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.0494 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0492 0.1442
Onchocerca volvulus 0.0022 0.0011 0.0076
Schistosoma mansoni cathepsin D (A01 family) 0.0425 0.1603 0.4696
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0015 0.0044
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.0379 0.1109
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0032 0.0052 0.0151
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0032 0.0052 0.0151
Brugia malayi hypothetical protein 0.0034 0.0059 0.0172
Trypanosoma brucei protein kinase, putative 0.005 0.012 0.0323
Loa Loa (eye worm) trypsin family protein 0.0023 0.0015 0.0044
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.012 0.0323
Trichomonas vaginalis GTP-binding protein rit, putative 0.0594 0.2272 0.6645
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0239 0.0871 0.2551
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0492 0.0492
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0048 0.0141
Brugia malayi Calcium binding EGF domain containing protein 0.0032 0.0052 0.0151
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0048 0.0141
Loa Loa (eye worm) hypothetical protein 0.0163 0.0567 0.1661
Onchocerca volvulus 0.0022 0.001 0.0075
Leishmania major lanosterol synthase, putative 0.0525 0.2001 0.5849
Echinococcus multilocularis protein dispatched 1 0.0151 0.0523 0.0523
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0048 0.0141
Loa Loa (eye worm) hypothetical protein 0.0146 0.05 0.1466
Echinococcus granulosus Niemann Pick C1 protein 0.0442 0.1672 0.4898
Loa Loa (eye worm) hypothetical protein 0.0034 0.0059 0.0172
Echinococcus granulosus neuropeptide receptor A26 0.0451 0.1706 0.4998
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0219 0.4301
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.0141
Schistosoma mansoni hypothetical protein 0.0128 0.043 0.126
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0492 0.1442
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0015 0.0015
Plasmodium falciparum plasmepsin III 0.0034 0.0059 0.0172
Onchocerca volvulus 0.0106 0.0345 0.2497
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.0318 0.0932
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0167 0.3225
Echinococcus multilocularis lamin dm0 0.0026 0.0028 0.0028
Echinococcus multilocularis transmembrane protease serine 3 0.0023 0.0015 0.0015
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0079 0.0235 0.4649
Trichomonas vaginalis CMGC family protein kinase 0.005 0.012 0.0323
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0765 0.2948 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0106 0.0312
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0015 0.0044
Onchocerca volvulus Cathepsin L homolog 0.0022 0.001 0.0075
Schistosoma mansoni hypothetical protein 0.0023 0.0015 0.0044
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0032 0.0052 0.0151
Echinococcus granulosus lamin 0.0026 0.0028 0.0082
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0059 0.0172
Brugia malayi CHE-14 protein 0.0133 0.0449 0.1315
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.012 0.0323
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0219 0.4301
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.0141
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.012 0.0353
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0239 0.0871 0.2551
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0074 0.0219 0.4301
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0239 0.0871 0.2528
Brugia malayi Eukaryotic aspartyl protease family protein 0.0034 0.0059 0.0172
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0144 0.0494 0.0494
Echinococcus granulosus enteropeptidase 0.0069 0.0197 0.0576
Echinococcus multilocularis fibrillin 1 0.0032 0.0052 0.0052
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0011 0.0031
Trichomonas vaginalis rap1 and, putative 0.0594 0.2272 0.6645
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0044
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0239 0.0871 0.2528
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0239 0.0871 0.2551
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0048 0.0141
Schistosoma mansoni hypothetical protein 0.0046 0.0106 0.0312
Schistosoma mansoni inositol monophosphatase 0.0079 0.0235 0.0689
Brugia malayi aspartic protease BmAsp-2, identical 0.0034 0.0059 0.0172
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0235 0.0661
Schistosoma mansoni hypothetical protein 0.0046 0.0106 0.0312
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0883 0.3414 1
Brugia malayi ecdysteroid receptor 0.0031 0.0048 0.0141
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.1092 0.3176
Onchocerca volvulus 0.0023 0.0015 0.0108
Brugia malayi Cathepsin L-like precursor 0.0022 0.001 0.003
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0034 0.0059 0.0142
Echinococcus granulosus tissue type plasminogen activator 0.0069 0.0197 0.0578
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0011 0.0031
Toxoplasma gondii calcium binding egf domain-containing protein 0.0032 0.0052 0.0121
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0011 0.0031
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0883 0.3414 1
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0239 0.0871 0.2528
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0239 0.0871 0.2551
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0401 0.1174
Trypanosoma cruzi lanosterol synthase, putative 0.0765 0.2948 0.8631
Onchocerca volvulus 0.0368 0.138 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0745 0.2871 0.8403
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0048 0.0141
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0015 0.0044
Echinococcus granulosus neuropeptide s receptor 0.0451 0.1706 0.4998
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0368 0.138 0.4043
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0132 0.0414
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0235 0.0661
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.1092 0.3176
Toxoplasma gondii aspartyl protease 0.0034 0.0059 0.0142
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0069 0.0197 0.0576
Echinococcus granulosus mitogen activated protein kinase 0.005 0.012 0.0353
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.1092 0.3176
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0368 0.138 0.4025
Onchocerca volvulus 0.0022 0.001 0.0075
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.1092 0.3176
Onchocerca volvulus 0.0022 0.0011 0.0076
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0368 0.138 0.4025
Schistosoma mansoni hypothetical protein 0.0069 0.0197 0.0578
Loa Loa (eye worm) hypothetical protein 0.0594 0.2272 0.6656
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0048 0.0141
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0219 0.064
Loa Loa (eye worm) hypothetical protein 0.01 0.0318 0.0932
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0063 0.0184
Schistosoma mansoni egf-like domain protein 0.0032 0.0052 0.0151
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0368 0.138 0.4043
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.0494 0.1647
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0239 0.0871 0.2551
Echinococcus multilocularis expressed conserved protein 0.0291 0.1073 0.1073
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0044
Echinococcus multilocularis musashi 0.0026 0.0028 0.0028
Onchocerca volvulus 0.0022 0.0011 0.0076
Plasmodium falciparum plasmepsin V 0.0034 0.0059 0.0172
Echinococcus granulosus cathepsin l cysteine peptidase 0.0022 0.001 0.003
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0059 0.0172
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0048 0.0141
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0492 0.0492
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0745 0.2871 0.8408
Schistosoma mansoni cathepsin D (A01 family) 0.0425 0.1603 0.4696
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0235 0.0661
Brugia malayi Ras-related protein R-Ras2 0.0594 0.2272 0.6656
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0883 0.3414 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0309 0.1147 0.336
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.012 0.0323
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0048 0.0141
Brugia malayi Ras protein let-60 0.0594 0.2272 0.6656
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.1092 0.3176
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0144 0.0492 0.1442
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0059 0.0172
Loa Loa (eye worm) hypothetical protein 0.0022 0.001 0.003
Schistosoma mansoni hypothetical protein 0.0128 0.043 0.126
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0048 0.0048
Entamoeba histolytica hypothetical protein 0.0035 0.0063 0.0154
Trichomonas vaginalis CMGC family protein kinase 0.005 0.012 0.0323
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0056 0.0144 0.0455
Echinococcus multilocularis Niemann Pick C1 protein 0.0442 0.1672 0.1672
Trypanosoma cruzi lanosterol synthase, putative 0.0765 0.2948 0.8631
Schistosoma mansoni hypothetical protein 0.0046 0.0106 0.0312
Toxoplasma gondii kringle domain-containing protein 0.0069 0.0197 0.055
Brugia malayi Kringle domain containing protein 0.0069 0.0197 0.0578
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0048 0.0141
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0076
Trichomonas vaginalis CMGC family protein kinase 0.005 0.012 0.0323
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0015 0.0044
Mycobacterium ulcerans hypothetical protein 0.0023 0.0015 0.0092
Echinococcus granulosus laminin 0.0032 0.0052 0.0151
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0883 0.3414 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0368 0.138 0.4025
Toxoplasma gondii calcium binding egf domain-containing protein 0.0032 0.0052 0.0121
Schistosoma mansoni hypothetical protein 0.0035 0.0063 0.0184
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0074 0.0219 0.4301
Plasmodium falciparum plasmepsin II 0.0144 0.0494 0.1446
Toxoplasma gondii aspartyl protease ASP3 0.0034 0.0059 0.0142
Brugia malayi Trypsin family protein 0.0023 0.0015 0.0044
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0048 0.0141
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0368 0.138 0.138
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.012 0.0323
Echinococcus multilocularis neuropeptide receptor A26 0.0451 0.1706 0.1706
Echinococcus multilocularis GPCR, family 2 0.0046 0.0106 0.0106
Plasmodium vivax geranylgeranyltransferase, putative 0.0239 0.0871 0.2551
Loa Loa (eye worm) hypothetical protein 0.0074 0.0219 0.064
Loa Loa (eye worm) hypothetical protein 0.0129 0.0436 0.1276
Echinococcus multilocularis cysteine protease 0.0022 0.001 0.001
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0167 0.0488
Schistosoma mansoni lamin 0.0026 0.0028 0.0082
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0368 0.138 0.4025
Brugia malayi hypothetical protein 0.0034 0.0059 0.0172
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0048 0.0141
Loa Loa (eye worm) hypothetical protein 0.0309 0.1147 0.336
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0167 0.0488
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0015 0.0044
Echinococcus granulosus GPCR family 2 0.0046 0.0106 0.0312
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0048 0.0141
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0219 0.4301
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.0141
Schistosoma mansoni inositol monophosphatase 0.0079 0.0235 0.0689
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0022 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0048 0.0141
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0368 0.138 0.4025
Echinococcus multilocularis glycoprotein Antigen 5 0.0069 0.0197 0.0197
Echinococcus granulosus sterol regulatory element binding protein 0.0133 0.0449 0.1315
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0219 0.064
Plasmodium vivax aspartyl protease, putative 0.0034 0.0059 0.0172
Giardia lamblia Rab geranylgeranyltransferase 0.0368 0.138 0.3825
Loa Loa (eye worm) hypothetical protein 0.0056 0.0144 0.0422
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0069 0.0197 0.0578
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0745 0.2871 0.8408
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0309 0.1147 0.334
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.0219 0.4301
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0048 0.0141
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0368 0.138 0.4025
Toxoplasma gondii hypothetical protein 0.0368 0.138 0.4025
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0079 0.0235 0.0661
Loa Loa (eye worm) TK/ROR protein kinase 0.0069 0.0197 0.0578
Plasmodium falciparum cysteine proteinase falcipain 3 0.0022 0.001 0.003
Schistosoma mansoni memapsin-2 (A01 family) 0.0034 0.0059 0.0172
Echinococcus granulosus Tolloid protein 1 0.0032 0.0052 0.0151
Echinococcus multilocularis ras gtpase 0.0594 0.2272 0.2272
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0048 0.0141
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0048 0.0141
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0048 0.0141
Schistosoma mansoni coup transcription factor 0.0031 0.0048 0.0141
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0048 0.0141
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0745 0.2871 0.2871
Loa Loa (eye worm) hypothetical protein 0.0144 0.0494 0.1446
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.0449 0.1289
Entamoeba histolytica acyl-coA synthetase, putative 0.0074 0.0219 0.0612
Giardia lamblia Rab geranylgeranyltransferase 0.0745 0.2871 0.835
Plasmodium falciparum acyl-CoA synthetase 0.0056 0.0144 0.0422
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0883 0.3414 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0015 0.0044
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0368 0.138 0.4043
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0368 0.138 0.4025
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0239 0.0871 0.2528
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0219 0.0612
Echinococcus granulosus intermediate filament protein 0.0026 0.0028 0.0082
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0048 0.0349
Plasmodium falciparum plasmepsin VIII, putative 0.0034 0.0059 0.0172
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0074 0.0219 0.0708
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0883 0.3414 0.3414
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0239 0.0871 0.2528
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0048 0.0141
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0235 0.0661
Loa Loa (eye worm) hypothetical protein 0.0032 0.0052 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0048 0.0141
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0082
Brugia malayi Cathepsin L-like precursor 0.0022 0.001 0.003
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0059 0.0172
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0883 0.3414 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0048 0.0141
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0133 0.0449 0.1315
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0132 0.0414
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0048 0.0141
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0048 0.0141
Plasmodium vivax vivapain-2 0.0022 0.001 0.003
Toxoplasma gondii hypothetical protein 0.0377 0.1414 0.4124
Mycobacterium ulcerans hypothetical protein 0.0074 0.0219 0.4301
Loa Loa (eye worm) fibroinase 0.0022 0.001 0.003
Plasmodium vivax aspartyl protease, putative 0.0034 0.0059 0.0172
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0023 0.0015 0.0044
Brugia malayi Calcitonin receptor-like protein seb-1 0.0146 0.05 0.1466
Onchocerca volvulus 0.0074 0.0219 0.1584
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0048 0.0349
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0219 0.0612
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.0141
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0745 0.2871 0.8403
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0745 0.2871 0.8408
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0239 0.0871 0.2551
Onchocerca volvulus 0.0023 0.0015 0.0108
Onchocerca volvulus 0.0026 0.0028 0.0202
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.0106 0.0312
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0235 0.0661
Plasmodium falciparum plasmepsin VI 0.0144 0.0494 0.1446
Onchocerca volvulus 0.0022 0.001 0.0075
Echinococcus multilocularis Mastin 0.0069 0.0197 0.0197
Echinococcus granulosus ras gtpase 0.0594 0.2272 0.6656
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.012 0.0323
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0368 0.138 0.4025
Echinococcus multilocularis enteropeptidase 0.0069 0.0197 0.0197
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0745 0.2871 0.8403
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.007 0.0203 0.3974
Echinococcus granulosus inositol monophosphatase 1 0.0079 0.0235 0.0689
Plasmodium vivax vivapain-2 0.0022 0.001 0.003
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0022 0.001 0.003
Brugia malayi Latrophilin receptor protein 2 0.0046 0.0106 0.0312
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0492 0.1442
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0059 0.0172
Schistosoma mansoni lipoxygenase 0.008 0.0242 0.0708
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0079 0.0235 0.5
Echinococcus multilocularis protein patched 0.0133 0.0449 0.0449
Trichomonas vaginalis rheb, putative 0.0594 0.2272 0.6645
Loa Loa (eye worm) hypothetical protein 0.0074 0.0219 0.064
Echinococcus granulosus cathepsin L cysteine proteinase 0.0022 0.001 0.003
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.012 0.0323
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0048 0.0048
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0048 0.0141
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0219 0.064
Plasmodium vivax acyl-CoA synthetase, putative 0.0056 0.0144 0.0422
Leishmania major farnesyltransferase beta subunit 0.0883 0.3414 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0048 0.0141
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0167 0.0459
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0132 0.0414
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0883 0.3414 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0167 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0048 0.0141
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0048 0.0141
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0129 0.0436 0.1276
Echinococcus granulosus transmembrane protease serine 3 0.0023 0.0015 0.0044
Leishmania major geranylgeranyltransferase, putative 0.0239 0.0871 0.2528
Brugia malayi Cathepsin L-like precursor 0.0022 0.001 0.003
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0219 0.0612
Loa Loa (eye worm) hypothetical protein 0.0032 0.0052 0.0151
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0144 0.0494 0.142
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0023 0.0015 0.0044
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.0141
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0028 0.0082
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0048 0.0141
Plasmodium falciparum plasmepsin IV 0.0144 0.0494 0.1446
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0883 0.3414 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0048 0.0048
Echinococcus granulosus expressed conserved protein 0.0291 0.1073 0.3143
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0883 0.3414 1
Trichomonas vaginalis dexras1, putative 0.0594 0.2272 0.6645
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0492 0.1442
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0144 0.0492 0.1442
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.0379 0.0379
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0239 0.0871 0.2551
Echinococcus multilocularis lamin 0.0026 0.0028 0.0028
Echinococcus multilocularis neuropeptide s receptor 0.0451 0.1706 0.1706
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0015 0.0044
Schistosoma mansoni lipoxygenase 0.0115 0.0379 0.1109
Brugia malayi aspartic protease BmAsp-1, identical 0.0034 0.0059 0.0172
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0011 0.0031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0044
Onchocerca volvulus Cathepsin L homolog 0.0022 0.001 0.0075
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.012 0.012
Onchocerca volvulus 0.0023 0.0015 0.0108
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0048 0.0141
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0745 0.2871 0.8408
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0023 0.0015 0.0044
Brugia malayi Trypsin family protein 0.0129 0.0436 0.1276
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0023 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0056 0.0144 0.0422
Loa Loa (eye worm) hypothetical protein 0.0032 0.0052 0.0151
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0056 0.0144 0.2762
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0048 0.0141
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0235 0.0661
Brugia malayi Protein kinase domain containing protein 0.0069 0.0197 0.0578
Brugia malayi Cathepsin L-like precursor 0.0022 0.001 0.003
Onchocerca volvulus 0.0023 0.0015 0.0108
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0167 0.3225
Brugia malayi Cathepsin L-like precursor 0.0022 0.001 0.003
Brugia malayi hypothetical protein 0.0023 0.0015 0.0044
Plasmodium vivax plasmepsin V, putative 0.0034 0.0059 0.0172
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0015 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0048 0.0141
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0011 0.0031
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0239 0.0871 0.2528
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0032 0.0052 0.0151
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0048 0.0048
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0015 0.0044
Brugia malayi Cathepsin L-like precursor 0.0022 0.001 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0368 0.138 0.4025
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0314 0.1166 0.3416
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.012 0.0353
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0129 0.0436 0.1276
Entamoeba histolytica Ras family GTPase 0.0594 0.2272 0.6645
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0048 0.0048
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0144 0.0494 0.142
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0059 0.0172
Leishmania major hypothetical protein, conserved 0.0069 0.0197 0.055
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.0106 0.0312
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0022 0.001 0.003
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0011 0.0031
Plasmodium vivax aspartyl proteinase, putative 0.0034 0.0059 0.0172
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0044
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0022 0.001 0.003
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0011 0.0031
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0368 0.138 0.138
Plasmodium falciparum plasmepsin IX 0.0034 0.0059 0.0172
Schistosoma mansoni hypothetical protein 0.0023 0.0015 0.0044
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0059 0.0172
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0011 0.0031
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0745 0.2871 0.8408
Echinococcus multilocularis cathepsin L cysteine protease 0.0022 0.001 0.001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.0106 0.0312
Onchocerca volvulus 0.0034 0.0059 0.0425
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0048 0.0141
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0011 0.0031
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0745 0.2871 0.8408
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0022 0.001 0.001
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0144 0.0494 0.1446
Onchocerca volvulus 0.0026 0.0028 0.0202
Plasmodium vivax aspartyl protease, putative 0.0034 0.0059 0.0172
Plasmodium vivax plasmepsin IV, putative 0.0144 0.0494 0.1446
Loa Loa (eye worm) hypothetical protein 0.0034 0.0059 0.0172
Loa Loa (eye worm) hypothetical protein 0.0032 0.0052 0.0151
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0028 0.0082
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0011 0.0011
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0022 0.001 0.003
Trypanosoma cruzi protein farnesyltransferase, putative 0.0883 0.3414 1
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0048 0.0141
Brugia malayi steroid hormone receptor 0.0031 0.0048 0.0141
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.1092 0.3176
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0883 0.3414 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0063 0.0184
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0239 0.0871 0.2528
Schistosoma mansoni cercarial elastase (S01 family) 0.0023 0.0015 0.0044
Echinococcus multilocularis tissue type plasminogen activator 0.0069 0.0197 0.0197
Echinococcus multilocularis Niemann Pick C1 protein 0.0309 0.1147 0.1147
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.0141
Onchocerca volvulus 0.0069 0.0197 0.1431
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0048 0.0141
Plasmodium falciparum geranylgeranyltransferase, putative 0.0239 0.0871 0.2551
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0048 0.0141
Loa Loa (eye worm) hypothetical protein 0.0056 0.0144 0.0422
Entamoeba histolytica ras-1, putative 0.0594 0.2272 0.6645
Trypanosoma cruzi hypothetical protein, conserved 0.0239 0.0871 0.2528
Echinococcus granulosus cathepsin l1 0.0022 0.001 0.003
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0883 0.3414 1
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0239 0.0871 0.2528
Brugia malayi intermediate filament protein 0.0026 0.0028 0.0082
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0219 0.4301
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0044
Schistosoma mansoni hypothetical protein 0.0128 0.043 0.126
Loa Loa (eye worm) Ras protein let-60 0.0594 0.2272 0.6656
Loa Loa (eye worm) hypothetical protein 0.0074 0.0219 0.064
Onchocerca volvulus 0.0129 0.0436 0.3156
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.001 0.003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0056 0.0144 0.0422
Schistosoma mansoni intermediate filament proteins 0.0026 0.0028 0.0082

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 76 nM In vitro inhibitory activity against coagulation factor X. ChEMBL. 15013007
IC50 (binding) = 76 nM In vitro inhibitory activity against coagulation factor X. ChEMBL. 15013007
IC50 (binding) > 11 uM Inhibitory activity against thrombin. ChEMBL. 15013007
IC50 (binding) > 11 uM Inhibitory activity against tissue type plasminogen activator. ChEMBL. 15013007
IC50 (binding) > 11 uM Inhibitory activity against trypsin. ChEMBL. 15013007
IC50 (binding) > 11 uM Inhibitory activity against activated protein C ChEMBL. 15013007
IC50 (binding) > 11 uM Inhibitory activity against plasmin. ChEMBL. 15013007
IC50 (binding) > 11 uM Inhibitory activity against thrombin. ChEMBL. 15013007
IC50 (binding) > 11 uM Inhibitory activity against tissue type plasminogen activator. ChEMBL. 15013007
IC50 (binding) > 11 uM Inhibitory activity against trypsin. ChEMBL. 15013007
IC50 (binding) > 11 uM Inhibitory activity against activated protein C ChEMBL. 15013007
IC50 (binding) > 11 uM Inhibitory activity against plasmin. ChEMBL. 15013007

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.