Detailed information for compound 312747

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 328.342 | Formula: C16H12N2O4S
  • H donors: 1 H acceptors: 4 LogP: 1.9 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=Cc1c(C(=O)N)c2c(n1S(=O)(=O)c1ccccc1)cccc2
  • InChi: 1S/C16H12N2O4S/c17-16(20)15-12-8-4-5-9-13(12)18(14(15)10-19)23(21,22)11-6-2-1-3-7-11/h1-10H,(H2,17,20)
  • InChiKey: FBUQCMCBMIQDJW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0019 0.0548 0.0697
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.028 0.5109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0277 0.5049
Schistosoma mansoni neurotransmitter gated ion channel 0.001 0.0261 0.0509
Loa Loa (eye worm) hypothetical protein 0.0004 0.0056 0.0071
Loa Loa (eye worm) hypothetical protein 0.0009 0.0213 0.027
Echinococcus granulosus poly adp ribose polymerase 2 0.001 0.0269 0.0303
Toxoplasma gondii F5/8 type C domain-containing protein 0.0011 0.028 0.4666
Onchocerca volvulus 0.0007 0.0173 0.0473
Trypanosoma cruzi glutaminyl cyclase, putative 0.0018 0.0518 0.1571
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.028 0.5109
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0019 0.0548 0.0548
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0549 0.0619
Loa Loa (eye worm) hypothetical protein 0.0019 0.0548 0.0697
Echinococcus multilocularis SAM domain containing protein 0.0006 0.0138 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.028 0.5109
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0004 0.0046 0.0051
Echinococcus multilocularis insulin receptor 0.005 0.1597 0.1801
Schistosoma mansoni tyrosine kinase 0.0084 0.2705 0.5343
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0019 0.0548 0.0697
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0004 0.0046 0.0051
Loa Loa (eye worm) hypothetical protein 0.0019 0.0548 0.0697
Schistosoma mansoni nicalin (M28 family) 0.0018 0.0518 0.1018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Echinococcus granulosus discoidin domain receptor 0.0085 0.2756 0.3108
Onchocerca volvulus 0.0009 0.0213 0.0583
Leishmania major hypothetical protein, conserved 0.0098 0.3173 1
Brugia malayi Liprin-alpha 2 0.0006 0.0138 0.0138
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0004 0.0046 0.083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0018 0.0518 0.1018
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.001 0.0269 0.0303
Plasmodium falciparum protein kinase, putative 0.0009 0.0213 0.7118
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0549 0.1673
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0007 0.0173 0.0173
Echinococcus granulosus SAM domain containing protein 0.0006 0.0138 0.0156
Loa Loa (eye worm) hypothetical protein 0.0019 0.0548 0.0697
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0269 0.4902
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0019 0.0548 0.0618
Loa Loa (eye worm) phosphatidylinositol kinase 0.0004 0.0046 0.0058
Brugia malayi Neurabin protein 1 0.0006 0.0138 0.0138
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0549 0.1609
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0018 0.0518 0.0584
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.0006 0.0138 0.0176
Onchocerca volvulus 0.0019 0.0548 0.1502
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0548 0.0548
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0018 0.0518 0.0584
Loa Loa (eye worm) hypothetical protein 0.0055 0.1743 0.2217
Brugia malayi hypothetical protein 0.0004 0.0042 0.0042
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0004 0.0042 0.0048
Entamoeba histolytica hypothetical protein 0.001 0.0269 0.4902
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0009 0.0213 0.027
Loa Loa (eye worm) hypothetical protein 0.0009 0.0213 0.027
Onchocerca volvulus Tankyrase homolog 0.0065 0.2083 0.571
Loa Loa (eye worm) hypothetical protein 0.0019 0.0548 0.0697
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.028 0.5109
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0007 0.0173 0.0195
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0549 0.0619
Schistosoma mansoni coup transcription factor 0.0007 0.0173 0.0335
Loa Loa (eye worm) hypothetical protein 0.001 0.0261 0.0332
Loa Loa (eye worm) hypothetical protein 0.0112 0.3648 0.4639
Echinococcus granulosus serine protein kinase ATM 0.0011 0.0277 0.0312
Loa Loa (eye worm) hypothetical protein 0.0012 0.0317 0.0403
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0518 0.9442
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0548 0.1077
Echinococcus granulosus tyrosine protein kinase shark 0.0002 0.0003 0.0004
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0549 0.1079
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0549 0.0698
Loa Loa (eye worm) hypothetical protein 0.0019 0.0548 0.0697
Echinococcus granulosus epidermal growth factor receptor 0.0155 0.5059 0.5705
Loa Loa (eye worm) hypothetical protein 0.0009 0.0213 0.027
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0004 0.0046 0.0051
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0549 0.0698
Brugia malayi conserved hypotetical protein 0.0004 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0009 0.0213 0.027
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0011 0.028 0.0316
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0548 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0277 0.5049
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0269 0.4902
Loa Loa (eye worm) hypothetical protein 0.0009 0.0213 0.027
Loa Loa (eye worm) hypothetical protein 0.0006 0.0138 0.0176
Loa Loa (eye worm) hypothetical protein 0.0007 0.0173 0.022
Schistosoma mansoni nuclear receptor nhr-48 0.0004 0.0042 0.0077
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0019 0.0548 0.0618
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.028 0.5109
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.028 0.5109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0317 0.5781
Loa Loa (eye worm) phosphatidylinositol 3 0.0004 0.0046 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0157 0.2865
Trichomonas vaginalis conserved hypothetical protein 0.0002 0 0.0006
Loa Loa (eye worm) LGC-31 protein 0.0019 0.0548 0.0697
Toxoplasma gondii hypothetical protein 0.0018 0.0518 0.9391
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0549 0.1673
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0009 0.0213 0.024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0518 0.0659
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0548 0.0548
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0004 0.0046 0.0051
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0019 0.0548 0.0697
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0004 0.0046 0.083
Schistosoma mansoni hypothetical protein 0.0006 0.0138 0.0267
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0019 0.0548 0.0697
Entamoeba histolytica zinc finger protein, putative 0.001 0.0269 0.4902
Trichomonas vaginalis PIKK family atypical protein kinase 0.0007 0.0157 0.2865
Brugia malayi hypothetical protein 0.0009 0.0213 0.0213
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0007 0.0173 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0277 0.5049
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0269 0.4902
Schistosoma mansoni poly [ADP-ribose] polymerase 0.001 0.0269 0.0525
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0004 0.0042 0.0116
Echinococcus multilocularis nuclear receptor nhr 48 0.0004 0.0042 0.0048
Schistosoma mansoni tankyrase 0.0072 0.2332 0.4606
Loa Loa (eye worm) hypothetical protein 0.0004 0.0042 0.0054
Loa Loa (eye worm) TK/INSR protein kinase 0.005 0.1597 0.2031
Schistosoma mansoni RAR-like nuclear receptor 0.0007 0.0173 0.0335
Onchocerca volvulus 0.0019 0.0548 0.1502
Loa Loa (eye worm) hypothetical protein 0.0004 0.0056 0.0071
Loa Loa (eye worm) hypothetical protein 0.0019 0.0548 0.0697
Entamoeba histolytica hypothetical protein 0.0004 0.0046 0.083
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0197 0.3596
Schistosoma mansoni tyrosine kinase 0.0081 0.2631 0.5196
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0004 0.0046 0.0083
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0006 0.0138 0.0176
Onchocerca volvulus 0.0004 0.0046 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.028 0.5109
Plasmodium falciparum LCCL domain-containing protein 0.0011 0.028 1
Onchocerca volvulus 0.0019 0.0548 0.1502
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0004 0.0046 0.0051
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0011 0.028 0.0316
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0009 0.0213 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0138 0.2522
Loa Loa (eye worm) hypothetical protein 0.0007 0.0173 0.022
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0269 0.444
Loa Loa (eye worm) hypothetical protein 0.001 0.0261 0.0332
Schistosoma mansoni glutaminyl-peptide cyclotransferase-related 0.0018 0.0518 0.1018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0007 0.0173 0.022
Onchocerca volvulus 0.0006 0.0138 0.0379
Echinococcus multilocularis glutaminyl peptide cyclotransferase 0.0112 0.3648 0.4114
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0277 0.0277
Schistosoma mansoni steroid hormone receptor ad4bp 0.0007 0.0173 0.0335
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0007 0.0173 0.0335
Schistosoma mansoni hypothetical protein 0.0004 0.0046 0.0083
Brugia malayi hypothetical protein 0.0006 0.0138 0.0138
Plasmodium vivax tyrosine kinase-like protein, putative 0.0009 0.0213 0.7118
Entamoeba histolytica hypothetical protein 0.0011 0.0277 0.5049
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0004 0.0046 0.0046
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0009 0.0213 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0269 0.4902
Loa Loa (eye worm) hypothetical protein 0.001 0.0261 0.0332
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0007 0.0173 0.0335
Echinococcus multilocularis epidermal growth factor receptor 0.0155 0.5059 0.5705
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.028 0.5109
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0004 0.0046 0.083
Schistosoma mansoni Fxna peptidase (M28 family) 0.0018 0.0518 0.1018
Echinococcus multilocularis nAChR subunit 0.001 0.0261 0.0294
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0004 0.0046 0.083
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0548 0.0548
Schistosoma mansoni hypothetical protein 0.0011 0.028 0.0548
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0213 0.0213
Brugia malayi nuclear receptor NHR-88 0.0004 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0007 0.0173 0.022
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.001 0.0261 0.0509
Trypanosoma cruzi glutaminyl cyclase, putative 0.0018 0.0518 0.1571
Echinococcus multilocularis FTZ F1 alpha 0.0007 0.0173 0.0195
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0004 0.0046 0.083
Echinococcus granulosus glutaminyl peptide cyclotransferase 0.0112 0.3648 0.4114
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0004 0.0046 0.0051
Echinococcus granulosus nAChR subunit 0.0019 0.0548 0.0618
Onchocerca volvulus 0.0019 0.0548 0.1502
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0548 0.0618
Echinococcus granulosus nuclear receptor nhr 48 0.0004 0.0042 0.0048
Echinococcus multilocularis tyrosine protein kinase shark 0.0002 0.0003 0.0004
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0213 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0007 0.0173 0.0173
Onchocerca volvulus 0.0009 0.0213 0.0583
Schistosoma mansoni poly [ADP-ribose] polymerase 0.001 0.0269 0.0525
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0011 0.0277 0.0312
Echinococcus multilocularis 0.0047 0.1501 0.1692
Brugia malayi ecdysteroid receptor 0.0007 0.0173 0.0173
Schistosoma mansoni zinc finger protein 0.0004 0.0042 0.0077
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0548 0.0548
Echinococcus granulosus ecdysone induced protein 78C 0.0007 0.0173 0.0195
Loa Loa (eye worm) TK/EGFR protein kinase 0.0155 0.5059 0.6433
Entamoeba histolytica ankyrin repeat protein 0.0002 0 0.0006
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0548 0.0548
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.0173 0.0195
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0007 0.0173 0.0473
Schistosoma mansoni acetylcholine receptor-related 0.0009 0.0213 0.0414
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0004 0.0042 0.0048
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0213 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.028 0.5109
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0549 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0009 0.0213 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0004 0.0056 0.0104
Loa Loa (eye worm) hypothetical protein 0.0007 0.0173 0.022
Trypanosoma brucei poly(adp-ribose) polymerase 0.001 0.0269 0.444
Loa Loa (eye worm) hypothetical protein 0.0004 0.0042 0.0054
Plasmodium vivax LCCL domain-containing protein 0.0011 0.028 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0004 0.0042 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0317 0.5781
Loa Loa (eye worm) hypothetical protein 0.0018 0.0518 0.0659
Entamoeba histolytica hypothetical protein 0.0004 0.0046 0.083
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0007 0.0173 0.0335
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0007 0.0173 0.0173
Schistosoma mansoni tyrosine kinase 0.0155 0.5059 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0019 0.0548 0.0618
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0004 0.0046 0.0051
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0548 0.0548
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0548 0.0548
Schistosoma mansoni hypothetical protein 0.0006 0.0138 0.0267
Onchocerca volvulus 0.0011 0.028 0.0768
Loa Loa (eye worm) phosphatidylinositol 3 0.0004 0.0046 0.0058
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0004 0.0046 0.083
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0007 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0004 0.0042 0.0054
Echinococcus multilocularis poly (ADP ribose) polymerase 0.001 0.0269 0.0303
Schistosoma mansoni thyroid hormone receptor 0.0007 0.0173 0.0335
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0549 0.0549
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0277 0.5049
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0549 1
Schistosoma mansoni sarm1 0.0006 0.0138 0.0267
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0009 0.0213 0.0213
Schistosoma mansoni tyrosine kinase 0.0084 0.2705 0.5343
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0138 0.2522
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0007 0.0173 0.0173
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0011 0.0277 0.0312
Toxoplasma gondii peptidase, M28 family protein 0.0018 0.0518 0.9391
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.001 0.0269 0.0743
Plasmodium falciparum LCCL domain-containing protein 0.0011 0.028 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0548 0.0618
Loa Loa (eye worm) hypothetical protein 0.0085 0.2756 0.3505
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0548 0.0618
Brugia malayi nuclear receptor NHR-67 0.0004 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Onchocerca volvulus 0.0004 0.0046 0.0125
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0004 0.0046 0.0046
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0004 0.0046 0.0083
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0549 0.1609
Brugia malayi hypothetical protein 0.0009 0.0213 0.0213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0277 0.5049
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0006 0.0138 0.0267
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0004 0.0046 0.083
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0018 0.0518 0.0584
Echinococcus granulosus discoidin domain containing receptor 2 0.0011 0.028 0.0316
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0007 0.0173 0.0195
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0018 0.0518 0.0584
Schistosoma mansoni btb and poz domain-containing protein 0.0011 0.028 0.0548
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0269 0.8868 1
Echinococcus granulosus liprin beta 1 0.0006 0.0138 0.0156
Schistosoma mansoni nuclear hormone receptor 0.0004 0.0042 0.0077
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0012 0.0317 0.5399
Brugia malayi excitatory GABA receptor EXP-1A 0.0019 0.0548 0.0548
Loa Loa (eye worm) hypothetical protein 0.0004 0.0042 0.0054
Brugia malayi hypothetical protein 0.0004 0.0042 0.0042
Echinococcus granulosus discoidin domain containing receptor 2 0.0011 0.028 0.0316
Loa Loa (eye worm) hypothetical protein 0.0009 0.0213 0.027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.0173 0.0195
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0004 0.0046 0.083
Loa Loa (eye worm) hypothetical protein 0.0006 0.0138 0.0176
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0111 0.3599 0.7112
Echinococcus granulosus FTZ F1 alpha 0.0007 0.0173 0.0195
Entamoeba histolytica hypothetical protein 0.001 0.0269 0.4902
Loa Loa (eye worm) hypothetical protein 0.0004 0.0056 0.0071
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0004 0.0042 0.0077
Loa Loa (eye worm) tnks protein 0.0066 0.2119 0.2695
Schistosoma mansoni nuclear receptor 0.0004 0.0042 0.0077
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0548 0.1077
Mycobacterium tuberculosis Conserved protein 0.0018 0.0518 1
Schistosoma mansoni nAChR subunit 0.0019 0.0548 0.1077
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0007 0.0173 0.0195
Loa Loa (eye worm) hypothetical protein 0.001 0.0261 0.0332
Brugia malayi Peptidase family M28 containing protein 0.0112 0.3648 0.3648
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0004 0.0056 0.0071
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0006 0.0138 0.0156
Loa Loa (eye worm) hypothetical protein 0.0077 0.2476 0.3148
Brugia malayi Nuclear hormone receptor-like 1 0.0004 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0011 0.028 0.0356
Echinococcus multilocularis liprin beta 1 0.0006 0.0138 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.001 0.0261 0.0261
Loa Loa (eye worm) hypothetical protein 0.0007 0.0173 0.022
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0007 0.0173 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0007 0.0157 0.0371
Trichomonas vaginalis c2h2 zinc finger protein, putative 0.0006 0.0138 0.2522
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0009 0.0213 0.024
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0004 0.0042 0.0048
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0004 0.0046 0.0083
Brugia malayi WGR domain containing protein 0.001 0.0269 0.0269
Schistosoma mansoni nAChR subunit 0.0019 0.0548 0.1077
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0004 0.0046 0.083
Loa Loa (eye worm) hypothetical protein 0.0009 0.0213 0.027
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0019 0.0548 0.0548
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0004 0.0046 0.0083
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0004 0.0042 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0007 0.0173 0.0173
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.001 0.0269 0.0303
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0004 0.0046 0.0046
Brugia malayi hypothetical protein 0.0006 0.0138 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0269 0.4902
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.0261 0.0261
Onchocerca volvulus Fxna peptidase homolog 0.0018 0.0518 0.142
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0019 0.0548 0.0548
Schistosoma mansoni nAChR subunit 0.0019 0.0548 0.1077
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.001 0.0261 0.0261
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0004 0.0056 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Toxoplasma gondii F5/8 type C domain-containing protein 0.0011 0.028 0.4666
Schistosoma mansoni tyrosine kinase 0.005 0.1597 0.3152
Leishmania major hypothetical protein, conserved 0.0018 0.0518 0.1511
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.005 0.1597 0.1801
Loa Loa (eye worm) hypothetical protein 0.0009 0.0213 0.027
Schistosoma mansoni thyroid hormone receptor 0.0007 0.0173 0.0335
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0007 0.0173 0.0195
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0019 0.0548 0.0618
Echinococcus granulosus Nuclear hormone receptor HR96 0.0004 0.0042 0.0048
Schistosoma mansoni tyrosine kinase 0.0081 0.2631 0.5196
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0011 0.028 0.5109
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0004 0.0046 0.083
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.001 0.0269 0.0743
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0004 0.0046 0.083
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0007 0.0173 0.0335
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0277 0.5049
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0007 0.0173 0.0173
Onchocerca volvulus Fxna peptidase homolog 0.0018 0.0518 0.142
Schistosoma mansoni discoidin domain receptor 0.0011 0.028 0.0548
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0004 0.0046 0.083
Schistosoma mansoni acetylcholine receptor subunit beta 0.0009 0.0213 0.0414
Entamoeba histolytica hypothetical protein 0.0004 0.0046 0.083
Loa Loa (eye worm) hypothetical protein 0.0019 0.0548 0.0697
Loa Loa (eye worm) phosphatidylinositol 3 0.0004 0.0046 0.0058
Brugia malayi leucyl aminopeptidase 0.0018 0.0518 0.0518
Entamoeba histolytica hypothetical protein 0.001 0.0269 0.4902
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0004 0.0046 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0007 0.0173 0.0473
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0004 0.0042 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0007 0.0173 0.0173
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0007 0.0173 0.0173
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0004 0.0046 0.083
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0008 0.0197 0.0223
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0009 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.001 0.0261 0.0332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0004 0.0046 0.083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0008 0.0197 0.0223
Loa Loa (eye worm) hypothetical protein 0.001 0.0261 0.0332
Echinococcus multilocularis liprin alpha 2 0.0006 0.0138 0.0156
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0019 0.0548 0.0618
Loa Loa (eye worm) hypothetical protein 0.0009 0.0213 0.027
Schistosoma mansoni discoidin domain receptor 0.0011 0.028 0.0548
Loa Loa (eye worm) hypothetical protein 0.0004 0.0042 0.0054
Plasmodium falciparum tyrosine kinase-like protein 0.0009 0.0213 0.7118
Brugia malayi nuclear receptor RXR 0.0004 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0064 0.2055 0.2613
Toxoplasma gondii PA14 domain-containing protein 0.0011 0.028 0.4666
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0518 0.9442
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0019 0.0548 0.0618
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0004 0.0046 0.083
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0004 0.0046 0.0083
Brugia malayi Nuclear hormone receptor-like 1 0.0007 0.0173 0.0173
Loa Loa (eye worm) nuclear receptor NHR-67 0.0004 0.0042 0.0054
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0004 0.0046 0.083
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0009 0.0213 0.024
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0011 0.0277 0.0541
Entamoeba histolytica hypothetical protein 0.001 0.0269 0.4902
Schistosoma mansoni nAChR subunit 0.0019 0.0548 0.1077
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0004 0.0046 0.0083
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.001 0.0269 0.4902
Giardia lamblia Kinase, NEK 0.0002 0.0003 0.0061
Onchocerca volvulus 0.0006 0.0138 0.0379
Loa Loa (eye worm) DR-78 0.0004 0.0042 0.0054
Schistosoma mansoni neurotransmitter gated ion channel 0.0009 0.0213 0.0414
Giardia lamblia Phosphatidylinositol 4-kinase 0.0004 0.0046 0.083
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0549 0.1673
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Loa Loa (eye worm) hypothetical protein 0.0004 0.0046 0.0058
Brugia malayi Furin-like cysteine rich region family protein 0.0155 0.5059 0.5059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0549 0.0619
Brugia malayi FAT domain containing protein 0.0008 0.0197 0.0197
Echinococcus multilocularis 0.0004 0.0046 0.0051
Loa Loa (eye worm) hypothetical protein 0.0018 0.0518 0.0659
Echinococcus granulosus insulin growth factor 1 receptor beta 0.005 0.1597 0.1801
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0548 0.1077
Brugia malayi coiled-coil like protein 1 0.0006 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0011 0.0277 0.0352
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0004 0.0056 0.0104
Schistosoma mansoni nAChR subunit 0.0019 0.0548 0.1077
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0019 0.0548 0.1077
Loa Loa (eye worm) hypothetical protein 0.0009 0.0213 0.027
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0549 0.1609
Loa Loa (eye worm) hypothetical protein 0.0019 0.0548 0.0697
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Mycobacterium tuberculosis Probable lipoprotein aminopeptidase LpqL 0.0018 0.0518 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.028 0.5109
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0007 0.0173 0.022
Loa Loa (eye worm) hypothetical protein 0.0004 0.0056 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0007 0.0173 0.0173
Schistosoma mansoni tyrosine kinase 0.0081 0.2631 0.5196
Echinococcus granulosus insulin receptor 0.005 0.1597 0.1801
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Loa Loa (eye worm) hypothetical protein 0.0004 0.0042 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0007 0.0173 0.0173
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0004 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.001 0.0269 0.0342
Brugia malayi photoreceptor-specific nuclear receptor 0.0007 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0004 0.0042 0.0054
Brugia malayi nicalin 0.0018 0.0518 0.0518
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0019 0.0548 0.0697
Entamoeba histolytica hypothetical protein 0.0004 0.0046 0.083
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0004 0.0046 0.083
Onchocerca volvulus 0.0009 0.0213 0.0583
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0004 0.0042 0.0077
Echinococcus multilocularis stromal interaction molecule 1 0.0006 0.0138 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.028 0.5109
Loa Loa (eye worm) GABA receptor subunit 0.001 0.0261 0.0332
Loa Loa (eye worm) hypothetical protein 0.0004 0.0042 0.0054
Brugia malayi nuclear hormone receptor family member nhr-6 0.0004 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0019 0.0548 0.0697
Entamoeba histolytica protein kinase rad3, putative 0.0011 0.0277 0.5049
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0548 0.0618
Onchocerca volvulus 0.0004 0.0042 0.0116
Loa Loa (eye worm) hypothetical protein 0.0007 0.0173 0.022
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0004 0.0046 0.0051
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0007 0.0173 0.022
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0019 0.0548 0.0618
Echinococcus granulosus poly ADP ribose polymerase 1 0.001 0.0269 0.0303
Brugia malayi Protein kinase domain containing protein 0.0087 0.283 0.283
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0004 0.0046 0.083
Brugia malayi hypothetical protein 0.0004 0.0056 0.0056
Loa Loa (eye worm) leucyl aminopeptidase 0.0018 0.0518 0.0659
Loa Loa (eye worm) hypothetical protein 0.0007 0.0173 0.022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0548 0.0697
Loa Loa (eye worm) hypothetical protein 0.0009 0.0213 0.027
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0277 0.0277
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0138 0.2522
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0019 0.0548 0.0618
Onchocerca volvulus Glutaminyl cyclase homolog 0.0112 0.3648 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0548 0.0548
Brugia malayi Nuclear hormone receptor E75 0.0004 0.0042 0.0042
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0019 0.0548 0.0697
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0011 0.028 0.0316
Loa Loa (eye worm) hypothetical protein 0.001 0.0261 0.0332
Trichomonas vaginalis Clan MH, family M28, aminopeptidase S-like metallopeptidase 0.0018 0.0518 0.9442
Schistosoma mansoni nAChR subunit 0.0009 0.0213 0.0414
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0019 0.0548 0.1077
Echinococcus multilocularis thyroid hormone receptor alpha 0.0007 0.0173 0.0195
Schistosoma mansoni hypothetical protein 0.0008 0.0197 0.0384
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0004 0.0042 0.0042
Onchocerca volvulus 0.001 0.0261 0.0715
Trypanosoma cruzi hypothetical protein, conserved 0.0094 0.3053 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0518 0.0659
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0004 0.0046 0.083
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0007 0.0173 0.0195
Loa Loa (eye worm) hypothetical protein 0.0128 0.4191 0.5329
Giardia lamblia Hypothetical protein 0.0004 0.0046 0.083
Loa Loa (eye worm) hypothetical protein 0.001 0.0261 0.0332
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0004 0.0042 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.028 0.5109
Loa Loa (eye worm) hypothetical protein 0.0019 0.0548 0.0697
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0269 0.4902
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0549 0.1609
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0549 0.1673
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0548 0.0697
Brugia malayi Cation transporter family protein 0.0019 0.0548 0.0548
Onchocerca volvulus 0.0004 0.0042 0.0116
Loa Loa (eye worm) hypothetical protein 0.0019 0.0548 0.0697
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0549 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0007 0.0173 0.022
Echinococcus multilocularis discoidin domain containing receptor 2 0.0011 0.028 0.0316
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0549 1
Brugia malayi Nuclear hormone receptor E75 0.0004 0.0042 0.0042
Schistosoma mansoni nuclear hormone receptor 0.0007 0.0173 0.0335
Entamoeba histolytica protein kinase, putative 0.0002 0 0.0006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0548 0.0697
Echinococcus multilocularis ecdysone induced protein 78C 0.0007 0.0173 0.0195
Leishmania major glutaminyl cyclase, putative 0.0018 0.0518 0.1511
Loa Loa (eye worm) hypothetical protein 0.0009 0.0213 0.027
Loa Loa (eye worm) hypothetical protein 0.001 0.0261 0.0332
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0004 0.0046 0.0051
Loa Loa (eye worm) hypothetical protein 0.0004 0.0046 0.0058
Schistosoma mansoni nuclear receptor 0.0004 0.0042 0.0077
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0011 0.028 0.4969
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0173 0.022
Schistosoma mansoni septate junction protein 0.0011 0.028 0.0548
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0012 0.0317 0.5399
Brugia malayi hypothetical protein 0.0009 0.0213 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0269 0.4902
Mycobacterium ulcerans hypothetical protein 0.0018 0.0518 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.0173 0.0195
Onchocerca volvulus 0.001 0.0261 0.0715
Echinococcus multilocularis nAChR subunit 0.0019 0.0548 0.0618
Toxoplasma gondii F5/8 type C domain-containing protein 0.0011 0.028 0.4666
Schistosoma mansoni retinoic acid receptor RXR 0.0007 0.0173 0.0335
Plasmodium vivax LCCL domain-containing protein 0.0011 0.028 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0019 0.0548 0.0697
Schistosoma mansoni hypothetical protein 0.0006 0.0138 0.0267
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0004 0.0046 0.083
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0548 0.0548
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.028 0.5109
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0269 0.8868 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0004 0.0046 0.083
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0011 0.0277 0.077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0004 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0009 0.0213 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.028 0.5109
Brugia malayi hypothetical protein 0.0004 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0004 0.0042 0.0054
Brugia malayi nuclear hormone receptor 0.0007 0.0173 0.0173
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0548 0.0618
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.028 0.5109
Brugia malayi hypothetical protein 0.0009 0.0213 0.0213
Loa Loa (eye worm) acetylcholine receptor protein 0.0009 0.0213 0.027
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0269 0.4902
Loa Loa (eye worm) hypothetical protein 0.0239 0.7864 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0004 0.0046 0.083
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0006 0.0138 0.0156
Brugia malayi nuclear receptor NHR-88 0.0007 0.0173 0.0173
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0548 0.0618
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0011 0.0277 0.4601
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0006 0.0138 0.0138
Echinococcus granulosus tankyrase 0.0072 0.2329 0.2626
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0548 0.0618
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.0261 0.0261
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0019 0.0548 0.0548
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0019 0.0548 0.0548
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0549 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0548 0.0697
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0549 0.1609
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0004 0.0042 0.0116
Brugia malayi Protein kinase domain containing protein 0.005 0.1597 0.1597
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0011 0.028 0.5109
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0549 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0548 0.0697
Loa Loa (eye worm) steroid hormone receptor 0.0007 0.0173 0.022
Loa Loa (eye worm) hypothetical protein 0.0004 0.0042 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0277 0.5049
Loa Loa (eye worm) nuclear hormone receptor 0.0004 0.0042 0.0054
Echinococcus granulosus discoidin domain containing receptor 2 0.0011 0.028 0.0316
Schistosoma mansoni tyrosine kinase 0.005 0.1597 0.3152
Brugia malayi nuclear hormone receptor family member odr-7 0.0004 0.0042 0.0042
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0011 0.028 0.5109
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0019 0.0548 0.0548
Brugia malayi WGR domain containing protein 0.001 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0006 0.0138 0.0176
Onchocerca volvulus 0.0087 0.283 0.7759
Loa Loa (eye worm) hypothetical protein 0.0004 0.0042 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0549 0.1079
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0019 0.0548 0.1077
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0549 1
Trichomonas vaginalis TKL family protein kinase 0.0002 0 0.0006
Trypanosoma brucei glutaminyl cyclase, putative 0.0018 0.0518 0.9391
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0011 0.0277 0.5049
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0004 0.0046 0.0083
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0548 0.0618
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0004 0.0042 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0007 0.0173 0.0173
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0548 0.0618
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0004 0.0046 0.0046
Loa Loa (eye worm) phosphatidylinositol 3 0.0004 0.0046 0.0058
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0084 0.2705 0.305
Brugia malayi nuclear hormone receptor 0.0004 0.0042 0.0042
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0007 0.0173 0.0195
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0548 0.0618
Echinococcus granulosus thyroid hormone receptor alpha 0.0004 0.0042 0.0048
Echinococcus granulosus Sterile alpha motif SAM 0.0006 0.0138 0.0156
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0548 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0549 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0197 0.0251
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0011 0.0277 0.077
Brugia malayi Cation transporter family protein 0.0019 0.0548 0.0548
Onchocerca volvulus 0.0019 0.0548 0.1502
Brugia malayi steroid hormone receptor 0.0007 0.0173 0.0173
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0004 0.0046 0.083
Schistosoma mansoni nAChR subunit 0.0009 0.0213 0.0414
Loa Loa (eye worm) phosphatidylinositol 3 0.0004 0.0046 0.0058
Onchocerca volvulus 0.0018 0.0518 0.142
Entamoeba histolytica hypothetical protein 0.001 0.0261 0.4755
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0548 0.0618
Echinococcus granulosus Nuclear hormone receptor HR96 0.0004 0.0042 0.0048
Echinococcus granulosus liprin alpha 2 0.0006 0.0138 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0518 0.9442
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0007 0.0173 0.0173
Echinococcus multilocularis discoidin domain containing receptor 2 0.0011 0.028 0.0316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Schistosoma mansoni dock 0.0011 0.028 0.0548
Echinococcus multilocularis serine protein kinase ATM 0.0011 0.0277 0.0312
Loa Loa (eye worm) hypothetical protein 0.0004 0.0042 0.0054
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0548 0.0697
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0138 0.2522
Loa Loa (eye worm) hypothetical protein 0.0009 0.0213 0.027
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0004 0.0056 0.0063
Mycobacterium ulcerans lipoprotein aminopeptidase LpqL 0.0018 0.0518 0.5
Schistosoma mansoni neurotransmitter gated ion channel 0.0009 0.0213 0.0414
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0019 0.0548 0.0618
Loa Loa (eye worm) hypothetical protein 0.0006 0.0138 0.0176
Loa Loa (eye worm) TK/DDR protein kinase 0.0077 0.2476 0.3148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0277 0.5049
Giardia lamblia GTOR 0.0019 0.0549 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0007 0.0173 0.0335
Loa Loa (eye worm) hypothetical protein 0.0004 0.0056 0.0071
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0019 0.0548 0.0548
Echinococcus granulosus epidermal growth factor receptor 0.0084 0.2705 0.305
Brugia malayi Steroid receptor seven-up type 2 0.0007 0.0173 0.0173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0007 0.0173 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0549 0.1673
Loa Loa (eye worm) hypothetical protein 0.0009 0.0213 0.027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.0173 0.0195
Brugia malayi Tnks protein 0.0072 0.2319 0.2319
Echinococcus multilocularis tankyrase 0.0072 0.2329 0.2626
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0018 0.0518 0.0584
Onchocerca volvulus Fxna peptidase homolog 0.0018 0.0518 0.142
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0548 0.0618
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0548 0.0697
Schistosoma mansoni lip-related protein (liprin) alpha 0.0006 0.0138 0.0267
Schistosoma mansoni nAChR subunit 0.0019 0.0548 0.1077
Brugia malayi tailless protein 0.0004 0.0042 0.0042
Echinococcus multilocularis discoidin domain receptor 0.0011 0.028 0.0316
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0011 0.028 1
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0548 0.0618
Loa Loa (eye worm) hypothetical protein 0.0019 0.0548 0.0697
Echinococcus granulosus stromal interaction molecule 1 0.0006 0.0138 0.0156
Schistosoma mansoni glutaminyl cyclase (M28 family) 0.0112 0.3648 0.7209
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0007 0.0173 0.0335
Brugia malayi nuclear receptor RXR 0.0004 0.0056 0.0056
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0004 0.0046 0.0051
Loa Loa (eye worm) hypothetical protein 0.0011 0.028 0.0356
Onchocerca volvulus Putative nachr subunit 0.0019 0.0548 0.1502
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0004 0.0046 0.0058
Loa Loa (eye worm) hypothetical protein 0.0004 0.0042 0.0054
Echinococcus multilocularis epidermal growth factor receptor 0.0084 0.2705 0.305
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0548 0.0618
Schistosoma mansoni fkbp-rapamycin associated protein 0.0011 0.0277 0.0541
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0007 0.0173 0.022
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0007 0.0173 0.0195
Brugia malayi FXNA 0.0018 0.0518 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Brugia malayi ecdysone receptor 0.0004 0.0042 0.0042
Trichomonas vaginalis hypothetical protein 0.0011 0.028 0.5109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Schistosoma mansoni nAChR subunit 0.0019 0.0548 0.1077
Echinococcus granulosus nAChR subunit 0.001 0.0261 0.0294
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.001 0.0261 0.0509
Trichomonas vaginalis PIKK family atypical protein kinase 0.0004 0.0046 0.083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0549 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0549 0.0619
Brugia malayi Cation transporter family protein 0.0019 0.0548 0.0548
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0006 0.0138 0.1845
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0007 0.0173 0.022
Brugia malayi orphan nuclear receptor NR2E1 0.0004 0.0042 0.0042
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0004 0.0046 0.0046
Onchocerca volvulus Bile acid receptor homolog 0.0007 0.0173 0.0473
Schistosoma mansoni nuclear hormone receptor 0.0004 0.0042 0.0077
Loa Loa (eye worm) hypothetical protein 0.0019 0.0548 0.0697
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0269 0.4902
Brugia malayi hypothetical protein 0.0009 0.0213 0.0213
Brugia malayi Nuclear hormone receptor-like 1 0.0004 0.0056 0.0056
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.001 0.0269 0.0342
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0004 0.0046 0.0051
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0009 0.0213 0.024
Loa Loa (eye worm) hypothetical protein 0.0007 0.0157 0.02
Onchocerca volvulus 0.0019 0.0548 0.1502
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0004 0.0046 0.083
Echinococcus multilocularis discoidin domain containing receptor 2 0.0011 0.028 0.0316
Echinococcus multilocularis Zinc finger, PHD finger 0.0004 0.0046 0.0051
Schistosoma mansoni hypothetical protein 0.0006 0.0138 0.0267
Toxoplasma gondii FATC domain-containing protein 0.0011 0.0277 0.4601
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0004 0.0046 0.083

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 32 uM Protection of infected MT-4 cells from wtIIIB-HIV-1-induced cytopathogenicity ChEMBL. 15634015
EC50 (functional) > 32 uM Protection of infected MT-4 cells from wtIIIB-HIV-1-induced cytopathogenicity ChEMBL. 15634015

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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