TDR Targets

Basic information

Technical information

TDR Targets ID: 336889
Name: (3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-meth yl-3-(trifluoromethyl)-6,7-dihydro-4H-pyrazol o[4,3-c]pyridin-5-yl]butan-1-one
MW: 402.362 | Formula: C18H19F5N4O
H donors: 1 H acceptors: 2 LogP: 1.73 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: N[C@H](Cc1cc(F)ccc1F)CC(=O)N1CCc2c(C1)c(n(n2)C)C(F)(F)F
InChi: 1S/C18H19F5N4O/c1-26-17(18(21,22)23)13-9-27(5-4-15(13)25-26)16(28)8-12(24)7-10-6-11(19)2-3-14(10)20/h2-3,6,12H,4-5,7-9,24H2,1H3/t12-/m1/s1
InChiKey: DXPLWSRNTJOVFI-GFCCVEGCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(trifluoromethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]-1-butanone
(3R)-3-azanyl-4-(2,5-difluorophenyl)-1-[2-methyl-3-(trifluoromethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dipeptidyl-peptidase 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	prolyl oligopeptidase family protein	Get druggable targets OG5_128614	All targets in OG5_128614
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	Get druggable targets OG5_128614	All targets in OG5_128614
Loa Loa (eye worm)	prolyl oligopeptidase	Get druggable targets OG5_128614	All targets in OG5_128614
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma japonicum	ko:K01278 dipeptidyl-peptidase 4, putative	Get druggable targets OG5_128614	All targets in OG5_128614
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	Get druggable targets OG5_128614	All targets in OG5_128614

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0313	0.3251	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0081	0.0707	0.2154
Entamoeba histolytica	cysteine proteinase, putative	0.0055	0.0423	0.5387
Onchocerca volvulus	Cathepsin L homolog	0.0037	0.0228	0.0822
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0064	0.0523	0.0515
Onchocerca volvulus	Cathepsin L homolog	0.0081	0.0707	0.2722
Echinococcus multilocularis	geminin	0.0502	0.5333	0.5324
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0513	0.0505
Echinococcus granulosus	lamin dm0	0.0038	0.0234	0.022
Brugia malayi	Pre-SET motif family protein	0.0129	0.1236	0.1228
Echinococcus multilocularis	GPCR, family 2	0.0021	0.0049	0.0031
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0081	0.0707	0.1584
Entamoeba histolytica	cysteine proteinase, putative	0.0055	0.0423	0.5387
Brugia malayi	cathepsin F-like cysteine proteinase	0.0037	0.0228	0.022
Echinococcus multilocularis	cysteine protease	0.0081	0.0707	0.069
Trypanosoma cruzi	cysteine peptidase, putative	0.0018	0.0012	0.0012
Leishmania major	cathepsin L-like protease	0.0081	0.0707	0.2154
Plasmodium falciparum	serine repeat antigen 2	0.0037	0.0228	0.3147
Toxoplasma gondii	cathepsin CPC2	0.0037	0.0228	0.0678
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0038	0.0232	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0317	0.0309
Onchocerca volvulus		0.0081	0.0707	0.2722
Plasmodium vivax	vivapain-1	0.0055	0.0423	0.5925
Brugia malayi	Cathepsin L-like precursor	0.0063	0.0513	0.0505
Leishmania major	cathepsin L-like protease	0.0081	0.0707	0.2154
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0021	0.0049	0.0031
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0037	0.0228	0.3147
Entamoeba histolytica	cysteine protease, putative	0.0055	0.0423	0.5387
Echinococcus multilocularis	survival motor neuron protein 1	0.0332	0.3463	0.3451
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.007	0.059	0.1793
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.002	0.0041	0.0032
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0081	0.0707	0.1584
Loa Loa (eye worm)	ctsf protein	0.0081	0.0707	0.0699
Brugia malayi	cathepsin L-like cysteine proteinase	0.0037	0.0228	0.022
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.007	0.059	0.059
Toxoplasma gondii	aldehyde dehydrogenase	0.0038	0.0232	0.0687
Echinococcus multilocularis	cathepsin L cysteine protease	0.0081	0.0707	0.069
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0055	0.0423	0.1276
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0081	0.0707	0.1584
Entamoeba histolytica	cysteine protease, putative	0.0081	0.0707	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0081	0.0707	0.1584
Brugia malayi	latrophilin 2 splice variant baaae	0.0046	0.0317	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0228	0.022
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0064	0.0523	0.0523
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0081	0.0707	0.1584
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0034	0.0188	0.0174
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0129	0.1236	0.1228
Echinococcus multilocularis	cathepsin b	0.0928	1	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0017	0.0009	0.0009
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0037	0.0228	0.022
Brugia malayi	Zinc finger, C2H2 type family protein	0.0213	0.2158	0.2152
Trypanosoma cruzi	major cysteine proteinase, putative	0.0037	0.0228	0.0228
Loa Loa (eye worm)	zinc finger protein	0.0213	0.2158	0.2152
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0064	0.0523	0.051
Echinococcus granulosus	cathepsin b	0.0928	1	1
Echinococcus granulosus	cathepsin L	0.0055	0.0423	0.0409
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0081	0.0707	0.0699
Brugia malayi	Cathepsin L-like precursor	0.0081	0.0707	0.0699
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.007	0.059	0.059
Onchocerca volvulus		0.0081	0.0707	0.2722
Echinococcus multilocularis	lamin dm0	0.0038	0.0234	0.0215
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0081	0.0707	0.1584
Brugia malayi	cytoplasmic intermediate filament protein	0.002	0.0041	0.0032
Loa Loa (eye worm)	cathepsin B	0.0313	0.3251	0.3245
Brugia malayi	hypothetical protein	0.0054	0.0408	0.04
Brugia malayi	Papain family cysteine protease containing protein	0.0037	0.0228	0.022
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0081	0.0707	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0037	0.0228	0.2241
Echinococcus granulosus	cathepsin l1	0.0063	0.0513	0.05
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0928	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0055	0.0423	0.0414
Echinococcus granulosus	GPCR family 2	0.0021	0.0049	0.0035
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0038	0.0232	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0064	0.0523	0.0505
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0037	0.0228	0.3147
Brugia malayi	Cathepsin L-like precursor	0.0063	0.0513	0.0505
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0034	0.0188	0.0188
Schistosoma mansoni	lamin	0.0038	0.0234	0.0234
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0081	0.0707	0.1584
Plasmodium falciparum	serine repeat antigen 4	0.0037	0.0228	0.3147
Schistosoma mansoni	survival motor neuron protein	0.0068	0.0561	0.0561
Entamoeba histolytica	hypothetical protein	0.0037	0.0228	0.2241
Echinococcus granulosus	cathepsin L	0.0037	0.0228	0.0215
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0037	0.0228	0.0678
Echinococcus granulosus	cathepsin b	0.0928	1	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0707	0.0699
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0081	0.0707	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0019	0.001
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0021	0.0049	0.004
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0067	0.0549	0.054
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0117	0.1098	0.1086
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0012	0.0003
Onchocerca volvulus		0.0081	0.0707	0.2722
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0038	0.0232	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0081	0.0707	0.1584
Brugia malayi	hypothetical protein	0.0332	0.3463	0.3457
Entamoeba histolytica	cysteine protease, putative	0.0055	0.0423	0.5387
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0055	0.0423	0.5925
Onchocerca volvulus		0.0063	0.0513	0.1952
Schistosoma mansoni	aldehyde dehydrogenase	0.0038	0.0232	0.0232
Onchocerca volvulus		0.0038	0.0234	0.0843
Schistosoma mansoni	hypothetical protein	0.0021	0.0049	0.0049
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0081	0.0707	0.069
Plasmodium vivax	unspecified product	0.0037	0.0228	0.3147
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0081	0.0707	0.1584
Onchocerca volvulus		0.003	0.0143	0.0483
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0928	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0037	0.0228	0.022
Onchocerca volvulus	Cathepsin F homolog	0.0081	0.0707	0.2722
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0081	0.0707	0.1584
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0019	0.0021	0.0021
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0037	0.0228	0.0228
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0037	0.0228	0.3147
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0081	0.0707	0.1584
Plasmodium vivax	unspecified product	0.0055	0.0423	0.5925
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0081	0.0707	0.1584
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0037	0.0228	0.3147
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0188	0.0179
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.007	0.059	0.1793
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0313	0.3251	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0081	0.0707	0.0707
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0018	0.0019	0.0005
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0081	0.0707	0.2154
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0037	0.0228	0.022
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0025	0.009	0.0077
Plasmodium vivax	vivapain-3	0.0055	0.0423	0.5925
Brugia malayi	mbt repeat family protein	0.003	0.0143	0.0134
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0081	0.0707	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0234	0.0225
Entamoeba histolytica	cysteine proteinase, putative	0.0081	0.0707	1
Schistosoma mansoni	hypothetical protein	0.0046	0.0317	0.0317
Brugia malayi	mbt repeat family protein	0.003	0.0143	0.0134
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0037	0.0228	0.3147
Schistosoma mansoni	aldehyde dehydrogenase	0.0038	0.0232	0.0232
Toxoplasma gondii	cathepsin CPL	0.0081	0.0707	0.2154
Echinococcus multilocularis	polycomb protein SCMH1	0.003	0.0143	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0228	0.022
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0055	0.0423	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0513	0.0505
Onchocerca volvulus	Huntingtin homolog	0.0248	0.2541	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0228	0.022
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0037	0.0228	0.0228
Entamoeba histolytica	cysteine protease, putative	0.0055	0.0423	0.5387
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0081	0.0707	0.1584
Loa Loa (eye worm)	prolyl oligopeptidase	0.0209	0.2115	0.2108
Echinococcus multilocularis	musashi	0.0038	0.0234	0.0215
Entamoeba histolytica	cysteine protease, putative	0.0055	0.0423	0.5387
Brugia malayi	prolyl oligopeptidase family protein	0.0209	0.2115	0.2108
Loa Loa (eye worm)	MH2 domain-containing protein	0.0082	0.0722	0.0713
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0209	0.2115	0.2115
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0081	0.0707	0.1584
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0081	0.0707	0.1584
Entamoeba histolytica	cysteine proteinase 2	0.0055	0.0423	0.5387
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0228	0.022
Brugia malayi	Cathepsin L-like precursor	0.0081	0.0707	0.0699
Onchocerca volvulus	Cathepsin L homolog	0.0081	0.0707	0.2722
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0081	0.0707	0.1584
Entamoeba histolytica	cysteine protease, putative	0.0037	0.0228	0.2241
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0081	0.0707	0.1584
Schistosoma mansoni	hypothetical protein	0.0068	0.0561	0.0561
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0064	0.0523	0.051
Schistosoma mansoni	sex comb on midleg homolog	0.003	0.0143	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0228	0.022
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0055	0.0423	0.0423
Trypanosoma cruzi	cysteine protease, putative	0.0055	0.0423	0.0423
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0055	0.0423	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0513	0.0505
Brugia malayi	Cathepsin L-like precursor	0.0081	0.0707	0.0699
Leishmania major	cathepsin L-like protease	0.0081	0.0707	0.2154
Onchocerca volvulus		0.0037	0.0228	0.0822
Entamoeba histolytica	cysteine protease, putative	0.0055	0.0423	0.5387
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0037	0.0228	0.022
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0012	0.0003
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0081	0.0707	0.2154
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0021	0.0049	0.004
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0209	0.2115	0.8308
Trypanosoma cruzi	cysteine peptidase, putative	0.0081	0.0707	0.0707
Plasmodium vivax	vivapain-2	0.0081	0.0707	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0082	0.0722	0.0713
Schistosoma mansoni	hypothetical protein	0.0502	0.5333	0.5333
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2541	0.2534
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0019	0.0021	0.0003
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0037	0.0228	0.3147
Echinococcus multilocularis	cathepsin b	0.0928	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0037	0.0228	0.022
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0055	0.0423	0.0423
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0928	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0081	0.0707	1
Onchocerca volvulus		0.0081	0.0707	0.2722
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0064	0.0523	0.0515
Entamoeba histolytica	cysteine proteinase, putative	0.0063	0.0513	0.6854
Schistosoma mansoni	lamin	0.0038	0.0234	0.0234
Plasmodium falciparum	serine repeat antigen 1	0.0037	0.0228	0.3147
Loa Loa (eye worm)	intermediate filament protein	0.0038	0.0234	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0021	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0549	0.054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0081	0.0707	0.2154
Leishmania major	cathepsin L-like protease	0.0081	0.0707	0.2154
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0081	0.0707	0.2154
Schistosoma mansoni	cathepsin s	0.0018	0.0012	0.0012
Plasmodium falciparum	serine repeat antigen 5	0.0037	0.0228	0.3147
Leishmania major	cathepsin L-like protease	0.0081	0.0707	0.2154
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0038	0.0234	0.0225
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0034	0.0188	0.017
Echinococcus granulosus	survival motor neuron protein 1	0.0332	0.3463	0.3454
Loa Loa (eye worm)	cysteine protease	0.0081	0.0707	0.0699
Brugia malayi	Cathepsin L-like precursor	0.0081	0.0707	0.0699
Entamoeba histolytica	cysteine protease, putative	0.0055	0.0423	0.5387
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0081	0.0707	0.2154
Entamoeba histolytica	cysteine protease, putative	0.0055	0.0423	0.5387
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0034	0.0188	0.017
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0313	0.3251	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0037	0.0228	0.0228
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0019	0.0021	0.0021
Trypanosoma cruzi	cysteine peptidase, putative	0.0055	0.0423	0.0423
Schistosoma mansoni	cathepsin F (C01 family)	0.0081	0.0707	0.0707
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0081	0.0707	0.1584
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0063	0.0513	0.0513
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0055	0.0423	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0228	0.022
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0021	0.0049	0.0035
Trypanosoma cruzi	PAB1-binding protein , putative	0.0017	0.0009	0.0009
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0063	0.0513	0.0942
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0067	0.0549	0.054
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0081	0.0707	0.069
Plasmodium falciparum	serine repeat antigen 6	0.0037	0.0228	0.3147
Echinococcus granulosus	Dipeptidyl peptidase 9	0.007	0.059	0.0577
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0064	0.0523	0.0523
Schistosoma mansoni	cathepsin B (C01 family)	0.0037	0.0228	0.0228
Schistosoma mansoni	cathepsin F (C01 family)	0.0081	0.0707	0.0707
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0081	0.0707	0.2154
Leishmania major	cathepsin L-like protease	0.0081	0.0707	0.2154
Entamoeba histolytica	cysteine protease, putative	0.0055	0.0423	0.5387
Leishmania major	cathepsin L-like protease	0.0081	0.0707	0.2154
Schistosoma mansoni	hypothetical protein	0.0502	0.5333	0.5333
Loa Loa (eye worm)	hypothetical protein	0.003	0.0143	0.0134
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0063	0.0513	0.0505
Entamoeba histolytica	cysteine protease, putative	0.0037	0.0228	0.2241
Plasmodium vivax	SET domain protein, putative	0.0019	0.0021	0.018
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.007	0.059	0.0573
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0038	0.0232	0.5
Echinococcus granulosus	polycomb protein SCMH1	0.003	0.0143	0.0129
Trypanosoma cruzi	cysteine proteinase, putative	0.0055	0.0423	0.0423
Schistosoma mansoni	transcription factor LCR-F1	0.0025	0.009	0.009
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0034	0.0188	0.0179
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0037	0.0228	0.3147
Toxoplasma gondii	cathepsin B	0.0313	0.3251	1
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0012	0.0003
Entamoeba histolytica	cysteine protease, putative	0.0037	0.0228	0.2241
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0012	0.0003
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0209	0.2115	0.2104
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0117	0.1098	0.1082
Echinococcus multilocularis	cathepsin L cysteine protease	0.0081	0.0707	0.069
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0012	0.0003
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0559	0.5955	0.5947
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0081	0.0707	0.0694
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0021	0.0049	0.0035
Brugia malayi	intermediate filament protein	0.0038	0.0234	0.0225
Giardia lamblia	Cathepsin B precursor	0.0313	0.3251	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0037	0.0228	0.022
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0081	0.0707	0.2154
Entamoeba histolytica	cysteine proteinase, putative	0.0055	0.0423	0.5387
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0081	0.0707	0.1584
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0081	0.0707	0.0694
Brugia malayi	hypothetical protein	0.0025	0.009	0.0082
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0037	0.0228	0.3147
Schistosoma mansoni	hypothetical protein	0.0025	0.009	0.009
Leishmania major	cathepsin L-like protease	0.0081	0.0707	0.2154
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0019	0.0021	0.0021
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.007	0.059	0.059
Schistosoma mansoni	hypothetical protein	0.0021	0.0049	0.0049
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0019	0.0021	0.0039
Brugia malayi	Pre-SET motif family protein	0.0019	0.0021	0.0013
Echinococcus granulosus	lamin	0.0038	0.0234	0.022
Onchocerca volvulus	Huntingtin homolog	0.0248	0.2541	1
Entamoeba histolytica	cysteine protease, putative	0.0037	0.0228	0.2241
Loa Loa (eye worm)	MBCTL1	0.0034	0.0188	0.0179
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0081	0.0707	0.1584
Trypanosoma cruzi	cruzipain precursor, putative	0.0018	0.0012	0.0012
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.007	0.059	0.1793
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0037	0.0228	0.3147
Schistosoma mansoni	sex comb on midleg homolog	0.003	0.0143	0.0143
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0037	0.0228	0.3147
Loa Loa (eye worm)	hypothetical protein	0.0928	1	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0025	0.009	0.0072
Plasmodium falciparum	serine repeat antigen 9	0.0037	0.0228	0.3147
Entamoeba histolytica	cysteine protease, putative	0.0055	0.0423	0.5387
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0038	0.0232	0.0218
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0037	0.0228	0.0228
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0037	0.0228	0.3147
Onchocerca volvulus		0.0147	0.1432	0.5597
Brugia malayi	cathepsin F-like cysteine proteinase	0.0018	0.0012	0.0003
Echinococcus multilocularis	cathepsin L	0.0037	0.0228	0.021
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0037	0.0228	0.3147
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0081	0.0707	0.0699
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0209	0.2115	0.21
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0081	0.0707	0.2154
Echinococcus multilocularis	cysteine protease	0.0081	0.0707	0.069
Entamoeba histolytica	cysteine protease, putative	0.0055	0.0423	0.5387
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0037	0.0228	0.0228
Echinococcus granulosus	histone lysine methyltransferase setb	0.0019	0.0021	0.0007
Brugia malayi	Cathepsin L-like precursor	0.0081	0.0707	0.0699
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0049	0.004
Echinococcus granulosus	intermediate filament protein	0.0038	0.0234	0.022
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0423	0.0642
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0037	0.0228	0.022
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0037	0.0228	0.0228
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0038	0.0232	0.0687
Echinococcus multilocularis	cathepsin L	0.0055	0.0423	0.0405
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.003	0.0143	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0011	0.0002
Plasmodium falciparum	serine repeat antigen 7	0.0037	0.0228	0.3147
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0011	0.0002
Schistosoma mansoni	intermediate filament proteins	0.0038	0.0234	0.0234
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0037	0.0228	0.3147
Brugia malayi	hypothetical protein	0.0248	0.2541	0.2534
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0019	0.0021	0.0003
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0038	0.0232	0.5
Giardia lamblia	Cathepsin B precursor	0.0313	0.3251	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0081	0.0707	0.0707
Brugia malayi	Latrophilin receptor protein 2	0.0021	0.0049	0.004
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0037	0.0228	0.2241
Entamoeba histolytica	cysteine protease, putative	0.0055	0.0423	0.5387
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0018	0.0012	0.0003
Echinococcus granulosus	histone acetyltransferase MYST2	0.0034	0.0188	0.0174
Entamoeba histolytica	cysteine protease, putative	0.0037	0.0228	0.2241
Onchocerca volvulus		0.0068	0.0561	0.2144
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0081	0.0707	0.1584
Schistosoma mansoni	hypothetical protein	0.0021	0.0049	0.0049
Entamoeba histolytica	cysteine proteinase, putative	0.0055	0.0423	0.5387
Onchocerca volvulus		0.0081	0.0707	0.2722
Schistosoma mansoni	hypothetical protein	0.0021	0.0049	0.0049
Entamoeba histolytica	cysteine proteinase 1, putative	0.0055	0.0423	0.5387
Entamoeba histolytica	cysteine protease, putative	0.0055	0.0423	0.5387
Echinococcus multilocularis	lamin	0.0038	0.0234	0.0215
Echinococcus granulosus	SAM and MBT domain containing protein	0.003	0.0143	0.0129
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0021	0.0049	0.0031
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0068	0.0561	0.0553
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0037	0.0228	0.0228
Trypanosoma cruzi	cysteine proteinase, putative	0.0055	0.0423	0.0423
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0081	0.0707	0.2154
Echinococcus granulosus	cathepsin L cysteine protease	0.0055	0.0423	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0332	0.3463	0.3457
Brugia malayi	MH2 domain containing protein	0.0082	0.0722	0.0713
Plasmodium vivax	unspecified product	0.0018	0.0012	0.0047
Echinococcus multilocularis	SAM and MBT domain containing protein	0.003	0.0143	0.0125
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0064	0.0523	0.0505
Trypanosoma cruzi	major cysteine proteinase, putative	0.0037	0.0228	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0408	0.04
Plasmodium vivax	vivapain-2	0.0081	0.0707	1
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2541	0.2534
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0081	0.0707	0.2154
Plasmodium vivax	serine-repeat antigen (SERA)	0.0037	0.0228	0.3147
Brugia malayi	cathepsin L precursor	0.0037	0.0228	0.022
Onchocerca volvulus		0.0081	0.0707	0.2722
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0313	0.3251	0.3251
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0423	0.0642
Echinococcus granulosus	cysteine protease	0.0055	0.0423	0.0409
Loa Loa (eye worm)	fibroinase	0.0081	0.0707	0.0699
Entamoeba histolytica	cysteine protease, putative	0.0055	0.0423	0.5387
Plasmodium falciparum	serine repeat antigen 3	0.0037	0.0228	0.3147
Brugia malayi	Papain family cysteine protease containing protein	0.0055	0.0423	0.0414
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.003	0.0143	0.0143
Trypanosoma cruzi	cruzipain precursor, putative	0.0081	0.0707	0.0707
Echinococcus granulosus	geminin	0.0502	0.5333	0.5326
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0019	0.0021	0.0021
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0081	0.0707	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0313	0.3251	0.3251
Entamoeba histolytica	cysteine protease, putative	0.0037	0.0228	0.2241
Echinococcus granulosus	zinc finger transcription factor gli2	0.0213	0.2158	0.2148
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0081	0.0707	0.1584
Schistosoma mansoni	hypothetical protein	0.018	0.1793	0.1793
Giardia lamblia	Cathepsin B precursor	0.0313	0.3251	1
Brugia malayi	Papain family cysteine protease containing protein	0.0037	0.0228	0.022
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0037	0.0228	0.0228
Brugia malayi	cathepsin L-like precursor	0.0063	0.0513	0.0505
Brugia malayi	Cathepsin L-like precursor	0.0081	0.0707	0.0699
Plasmodium falciparum	serine repeat antigen 8	0.0037	0.0228	0.3147
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0928	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0928	1	1
Onchocerca volvulus		0.0038	0.0234	0.0843
Leishmania major	cysteine peptidase A (CPA)	0.0081	0.0707	0.2154
Schistosoma mansoni	cathepsin S (C01 family)	0.0037	0.0228	0.0228
Trypanosoma cruzi	cysteine peptidase, putative	0.0081	0.0707	0.0707
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0037	0.0228	0.0228
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0081	0.0707	1
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.007	0.059	0.1793
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0063	0.0513	0.0942
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0081	0.0707	0.1584
Schistosoma mansoni	cathepsin F (C01 family)	0.0063	0.0513	0.0513
Onchocerca volvulus		0.0081	0.0707	0.2722
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0226	0.0217
Plasmodium vivax	serine-repeat antigen (SERA)	0.0037	0.0228	0.3147
Trichomonas vaginalis	set domain proteins, putative	0.0147	0.1432	0.3981
Toxoplasma gondii	cathepsin CPC1	0.0037	0.0228	0.0678
Loa Loa (eye worm)	mbt repeat family protein	0.003	0.0143	0.0134
Echinococcus multilocularis	zinc finger transcription factor gli2	0.0213	0.2158	0.2144
Schistosoma mansoni	cathepsin C	0.0037	0.0228	0.0228
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0067	0.0549	0.054
Brugia malayi	prolyl oligopeptidase family protein	0.007	0.059	0.0582
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0064	0.0523	0.0523
Brugia malayi	fibroinase precursor	0.0037	0.0228	0.022
Echinococcus granulosus	cathepsin l1	0.0081	0.0707	0.0694
Brugia malayi	Intermediate filament tail domain containing protein	0.0038	0.0234	0.0225
Brugia malayi	Papain family cysteine protease containing protein	0.0081	0.0707	0.0699

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.15 uM	Inhibitory concentration against human dipeptidyl-peptidase IV	ChEMBL.	15837304
IC50 (binding)	= 0.15 uM	Inhibitory concentration against human dipeptidyl-peptidase IV	ChEMBL.	15837304
IC50 (binding)	= 51 uM	Inhibitory concentration against human dipeptidyl-peptidase VII (QPP)	ChEMBL.	15837304
IC50 (binding)	= 51 uM	Inhibitory concentration against human dipeptidyl-peptidase VII (QPP)	ChEMBL.	15837304
IC50 (binding)	> 100 uM	Inhibitory concentration against human dipeptidyl-peptidase 8	ChEMBL.	15837304
IC50 (binding)	> 100 uM	Inhibitory concentration against human dipeptidyl-peptidase 9	ChEMBL.	15837304
IC50 (binding)	> 100 uM	Inhibitory concentration against human dipeptidyl-peptidase 8	ChEMBL.	15837304
IC50 (binding)	> 100 uM	Inhibitory concentration against human dipeptidyl-peptidase 9	ChEMBL.	15837304

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL191805
PubChem: 23645920

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 336889