Detailed information for compound 338842

Basic information

Technical information
  • TDR Targets ID: 338842
  • Name: methyl 2-[4-[[[3-[(2-methoxyacetyl)amino]pyri din-2-yl]amino]methyl]phenyl]benzoate
  • MW: 405.446 | Formula: C23H23N3O4
  • H donors: 2 H acceptors: 3 LogP: 3.2 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCC(=O)Nc1cccnc1NCc1ccc(cc1)c1ccccc1C(=O)OC
  • InChi: 1S/C23H23N3O4/c1-29-15-21(27)26-20-8-5-13-24-22(20)25-14-16-9-11-17(12-10-16)18-6-3-4-7-19(18)23(28)30-2/h3-13H,14-15H2,1-2H3,(H,24,25)(H,26,27)
  • InChiKey: ZLYBATPQQQIGSX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 2-[4-[[[3-[(2-methoxyacetyl)amino]-2-pyridyl]amino]methyl]phenyl]benzoate
  • 2-[4-[[[3-[(2-methoxy-1-oxoethyl)amino]-2-pyridyl]amino]methyl]phenyl]benzoic acid methyl ester
  • methyl 2-[4-[[[3-(2-methoxyethanoylamino)pyridin-2-yl]amino]methyl]phenyl]benzoate
  • 2-[4-[[[3-[(2-methoxyacetyl)amino]-2-pyridyl]amino]methyl]phenyl]benzoic acid methyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bradykinin receptor B1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0138 0.2933 0.6902
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0164 0.0375
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0144 0.3052 0.4748
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0348 0.765 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.6403 1
Treponema pallidum thioredoxin reductase (trxB) 0.0144 0.3052 0.4748
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0362 0.0851
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0561 0.8432
Loa Loa (eye worm) hypothetical protein 0.015 0.3188 0.7294
Loa Loa (eye worm) hypothetical protein 0.0032 0.0551 0.126
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.057 0.8573
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0546 0.1249
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0016 0.0037
Leishmania major T-complex protein 1, beta subunit, putative 0.0023 0.0352 0.5296
Trypanosoma cruzi trypanothione reductase, putative 0.0009 0.0022 0.0338
Loa Loa (eye worm) hypothetical protein 0.0036 0.0637 0.1457
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0362 0.112
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0164 0.2462
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.1265 0.2976
Brugia malayi major facilitator superfamily protein 0.0015 0.0164 0.0375
Loa Loa (eye worm) hypothetical protein 0.0124 0.2605 0.5959
Loa Loa (eye worm) glutathione reductase 0.0009 0.0022 0.0051
Leishmania major hypothetical protein, conserved 0.0009 0.0022 0.0338
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0009 0.0022 0.0338
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0637 0.1234
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0193 0.0455
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0164 0.0466
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0662 0.1557
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0107 0.2224 0.5233
Trypanosoma brucei glucose transporter, putative 0.0033 0.057 0.8573
Trypanosoma brucei glucose transporter 2A 0.0033 0.057 0.8573
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0193 0.2909
Onchocerca volvulus 0.0015 0.0164 0.23
Schistosoma mansoni Smad4 0.0008 0.0016 0.0037
Toxoplasma gondii sugar transporter ST1 0.0015 0.0164 0.0215
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0009 0.0022 0.0338
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0637 0.1457
Trypanosoma cruzi hexose transporter, putative 0.0033 0.057 0.8573
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0561 0.1283
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0164 0.0221
Plasmodium falciparum hexose transporter 0.0107 0.2224 0.2224
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0164 0.0164
Echinococcus multilocularis pyruvate kinase 0.0017 0.0198 0.0467
Toxoplasma gondii sugar transporter ST2 0.0015 0.0164 0.0215
Loa Loa (eye worm) hypothetical protein 0.0015 0.0164 0.0375
Schistosoma mansoni hypothetical protein 0.0107 0.2224 0.5233
Schistosoma mansoni smad1 5 8 and 0.0008 0.0016 0.0037
Onchocerca volvulus 0.0015 0.0164 0.23
Loa Loa (eye worm) T-complex protein 1 0.0023 0.0352 0.0806
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0164 0.2462
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0023 0.0352 0.5296
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0022 0.0338
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.6403 1
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0009 0.0022 0.0338
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0144 0.3052 0.4748
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0022 0.0338
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0546 0.1284
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0009 0.0022 0.0029
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0009 0.0022 0.0053
Brugia malayi Cam kinase protein 1 0.0033 0.0561 0.1283
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0193 0.0443
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0546 0.1249
Onchocerca volvulus 0.0036 0.0637 1
Trypanosoma cruzi NADH dehydrogenase, putative 0.0009 0.0022 0.0338
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0144 0.3052 0.6084
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0637 0.1234
Entamoeba histolytica hypothetical protein 0.0037 0.0662 0.0865
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.0025 0.0387 0.0886
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Plasmodium falciparum glutathione reductase 0.0009 0.0022 0.0022
Echinococcus granulosus intermediate filament protein 0.0028 0.0449 0.1056
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0362 0.0851
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0023 0.0352 0.5296
Loa Loa (eye worm) hypothetical protein 0.0013 0.0116 0.0264
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0099 0.2053 0.2683
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0362 0.112
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2224 0.5233
Loa Loa (eye worm) hypothetical protein 0.0197 0.425 0.9722
Leishmania major protein kinase, putative 0.0033 0.0561 0.8432
Brugia malayi T-complex protein 1, beta subunit 0.0023 0.0352 0.0806
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0193 0.0455
Trichomonas vaginalis esterase, putative 0.0036 0.0637 0.0963
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0172 0.37 0.5592
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0193 0.2909
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0387 0.5821
Schistosoma mansoni transient receptor potential channel 0.013 0.2752 0.6476
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0172 0.37 0.37
Brugia malayi Sugar transporter family protein 0.0015 0.0164 0.0375
Schistosoma mansoni hypothetical protein 0.0064 0.1265 0.2976
Schistosoma mansoni hypothetical protein 0.0011 0.0078 0.0184
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0022 0.0053
Loa Loa (eye worm) hypothetical protein 0.0073 0.1472 0.3367
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0164 0.0221
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0009 0.0022 0.0338
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0016 0.0036
Echinococcus multilocularis General substrate transporter 0.0092 0.1887 0.444
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0261 0.3925
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0009 0.0022 0.0338
Loa Loa (eye worm) hypothetical protein 0.015 0.3188 0.7294
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0046 0.0105
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0016 0.0037
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0362 0.0362
Entamoeba histolytica hypothetical protein 0.0037 0.0662 0.0865
Brugia malayi hypothetical protein 0.0037 0.0662 0.1514
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0164 0.0466
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0387 0.5821
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.016 0.0366
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.2224 0.5233
Echinococcus multilocularis GPCR, family 2 0.0064 0.1265 0.2976
Trypanosoma cruzi hexose transporter, putative 0.0033 0.057 0.8573
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0144 0.3052 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0561 0.1319
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0362 0.544
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0546 0.1284
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.3039 0.9957
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0022 0.0338
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0281 0.0854
Echinococcus multilocularis transient receptor potential gamma protein 0.0197 0.425 1
Trichomonas vaginalis glucose transporter, putative 0.0033 0.057 0.0858
Schistosoma mansoni glucose transport protein 0.0107 0.2224 0.5233
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0362 0.0532
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0637 0.1234
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0637 0.9578
Leishmania major pyruvate kinase 0.0032 0.0551 0.8284
Loa Loa (eye worm) hypothetical protein 0.0015 0.0164 0.0375
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.3039 0.6058
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0009 0.0022 0.0053
Schistosoma mansoni pyruvate kinase 0.0032 0.0551 0.1296
Onchocerca volvulus 0.0036 0.0637 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.0551 0.1744
Loa Loa (eye worm) hypothetical protein 0.0015 0.0164 0.0375
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0009 0.0022 0.0338
Echinococcus granulosus solute carrier family 22 0.0015 0.0164 0.0385
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Loa Loa (eye worm) hypothetical protein 0.0015 0.0164 0.0375
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.0551 0.0803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0022 0.0338
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.2933 0.671
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0561 0.0819
Onchocerca volvulus 0.0015 0.0164 0.23
Loa Loa (eye worm) hypothetical protein 0.0036 0.0637 0.1457
Echinococcus multilocularis thioredoxin glutathione reductase 0.0009 0.0022 0.0053
Echinococcus granulosus Smad4 0.0008 0.0016 0.0037
Leishmania major glucose transporter, lmgt1 0.0033 0.057 0.8573
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0016 0.0036
Echinococcus granulosus pyruvate kinase 0.0032 0.0551 0.1296
Plasmodium falciparum ferrodoxin reductase-like protein 0.0009 0.0022 0.0022
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0193 0.026
Echinococcus multilocularis lamin 0.0028 0.0449 0.1056
Entamoeba histolytica disulphide oxidoreductase, putative 0.0009 0.0022 0.0029
Leishmania major hypothetical protein, conserved 0.0025 0.0387 0.5821
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0009 0.0022 0.0053
Echinococcus multilocularis dna polymerase eta 0.0019 0.0261 0.0614
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0009 0.0022 0.0338
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0449 0.1027
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0164 0.0375
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.1265 0.2893
Leishmania major hypothetical protein, conserved 0.0036 0.0637 0.9578
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0233 0.3505
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0164 0.0466
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0009 0.0022 0.0338
Echinococcus granulosus lamin 0.0028 0.0449 0.1056
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0261 0.0614
Trypanosoma brucei sugar transporter, putative 0.0015 0.0164 0.2462
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.6403 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.2224 0.5233
Leishmania major hypothetical protein, conserved 0.0009 0.0022 0.0338
Loa Loa (eye worm) hypothetical protein 0.0013 0.0116 0.0264
Mycobacterium tuberculosis Conserved protein 0.0036 0.0637 0.1234
Leishmania major hypothetical protein, conserved 0.0015 0.0164 0.2462
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.057 0.0858
Onchocerca volvulus 0.0015 0.0164 0.23
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0551 0.126
Loa Loa (eye worm) hypothetical protein 0.0067 0.1324 0.3029
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.057 0.8573
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0009 0.0022 0.0338
Onchocerca volvulus 0.0015 0.0164 0.23
Trichomonas vaginalis glucose transporter, putative 0.0033 0.057 0.0858
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0637 0.2028
Trypanosoma brucei pyruvate kinase 1 0.0032 0.0551 0.8284
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0362 0.544
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0637 0.1499
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0546 0.1727
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.2598 0.5943
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0551 0.126
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0009 0.0022 0.0051
Brugia malayi Sugar transporter family protein 0.0107 0.2224 0.5087
Plasmodium falciparum mitogen-activated protein kinase 2 0.0172 0.37 0.37
Schistosoma mansoni sugar transporter 0.0015 0.0164 0.0385
Entamoeba histolytica protein kinase, putative 0.0033 0.0561 0.0733
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0126 0.1898
Schistosoma mansoni transient receptor potential channel 4 0.0197 0.425 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0164 0.0375
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0362 0.0445
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0637 0.0963
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0665 1
Giardia lamblia Pyruvate kinase 0.0017 0.0198 0.0231
Leishmania major trypanothione reductase 0.0009 0.0022 0.0338
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0127 0.0299
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0009 0.0022 0.0338
Mycobacterium ulcerans hypothetical protein 0.0036 0.0637 0.2028
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.016 0.0366
Trypanosoma brucei glucose transporter 1E 0.0033 0.057 0.8573
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0261 0.0374
Loa Loa (eye worm) hypothetical protein 0.0202 0.4371 1
Brugia malayi beta-lactamase family protein 0.0036 0.0637 0.1457
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0023 0.0352 0.0829
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0051
Loa Loa (eye worm) Smad1 0.0008 0.0016 0.0036
Loa Loa (eye worm) hypothetical protein 0.0015 0.0164 0.0375
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0009 0.0022 0.0053
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0009 0.0022 0.0029
Echinococcus granulosus smad 0.0008 0.0016 0.0037
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0387 0.5821
Schistosoma mansoni sugar transporter 0.0015 0.0164 0.0385
Echinococcus multilocularis solute carrier family 22 0.0015 0.0164 0.0385
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.0022 0.0051
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0009 0.0022 0.0022
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0164 0.0221
Loa Loa (eye worm) hypothetical protein 0.0032 0.0546 0.1249
Mycobacterium tuberculosis Conserved protein 0.0036 0.0637 0.1234
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0561 0.1319
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0193 0.0455
Echinococcus granulosus pyruvate kinase 0.0032 0.0551 0.1296
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0009 0.0022 0.0051
Loa Loa (eye worm) hypothetical protein 0.0015 0.0164 0.0375
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0164 0.0215
Entamoeba histolytica thioredoxin reductase, putative 0.0144 0.3052 0.399
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0016 0.0037
Brugia malayi Thioredoxin reductase 0.0009 0.0022 0.0051
Giardia lamblia DNA repair protein RAD52 0.0348 0.765 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0637 0.0963
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0551 0.126
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.5003 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0164 0.0375
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0022 0.0053
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0164 0.2462
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0009 0.0022 0.0022
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0561 0.0843
Plasmodium falciparum thioredoxin reductase 0.0009 0.0022 0.0022
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0362 0.112
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0009 0.0022 0.0029
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0144 0.3052 0.4748
Schistosoma mansoni glucose transport protein 0.0107 0.2224 0.5233
Loa Loa (eye worm) hypothetical protein 0.0024 0.0362 0.0828
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Trypanosoma brucei glucose transporter, putative 0.0033 0.057 0.8573
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0551 0.0828
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0009 0.0022 0.0338
Leishmania major DNA polymerase eta, putative 0.0019 0.0261 0.3925
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1905 0.4484
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0362 0.0516
Schistosoma mansoni hypothetical protein 0.0037 0.0662 0.1557
Loa Loa (eye worm) hypothetical protein 0.0019 0.0261 0.0597
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0665 1
Schistosoma mansoni glucose transporter 0.0015 0.0164 0.0385
Loa Loa (eye worm) hypothetical protein 0.0028 0.0449 0.1027
Echinococcus multilocularis muscleblind protein 1 0.015 0.3188 0.7502
Onchocerca volvulus 0.0015 0.0164 0.23
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.6403 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0261 0.0614
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0009 0.0022 0.0338
Plasmodium vivax ferrodoxin reductase, putative 0.0009 0.0022 0.0022
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0016 0.0037
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0561 0.0819
Giardia lamblia Pyruvate kinase 0.0032 0.0551 0.0693
Onchocerca volvulus 0.0015 0.0164 0.23
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0261 0.3925
Loa Loa (eye worm) programmed cell death 8 0.0009 0.0022 0.0051
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Schistosoma mansoni hypothetical protein 0.0064 0.1265 0.2976
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0164 0.0284
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0561 0.1283
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0009 0.0022 0.0022
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0164 0.2462
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0561 0.0561
Echinococcus granulosus transient receptor potential ion channel A 0.019 0.4102 0.9653
Trypanosoma brucei glucose transporter, putative 0.0033 0.057 0.8573
Onchocerca volvulus 0.0015 0.0164 0.23
Brugia malayi glutamate synthase 0.0009 0.0022 0.0051
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0261 0.3925
Loa Loa (eye worm) hypothetical protein 0.0138 0.2933 0.671
Leishmania major hypothetical protein, conserved 0.0009 0.0022 0.0338
Echinococcus multilocularis musashi 0.0028 0.0449 0.1056
Loa Loa (eye worm) hypothetical protein 0.0026 0.0411 0.094
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0637 0.9578
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0261 0.0341
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0546 0.1284
Echinococcus multilocularis short transient receptor potential channel 6 0.013 0.2752 0.6476
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0261 0.0614
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1905 0.4484
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0009 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.2224 0.345
Schistosoma mansoni smad1 5 8 and 0.0008 0.0016 0.0037
Brugia malayi hypothetical protein 0.0025 0.0387 0.0886
Schistosoma mansoni sugar transporter 0.0015 0.0164 0.0385
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0362 0.0851
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0281 0.0519
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0261 0.0614
Trichomonas vaginalis sugar transporter, putative 0.0033 0.057 0.0858
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0009 0.0022 0.0029
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0637 0.1234
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0561 0.0561
Brugia malayi MH2 domain containing protein 0.0008 0.0016 0.0036
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.6403 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0164 0.0375
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0296 0.0428
Trypanosoma cruzi hexose transporter, putative 0.0033 0.057 0.8573
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.2224 0.5233
Onchocerca volvulus 0.0015 0.0164 0.23
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.1905 0.4359
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0561 0.0561
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0127 0.0299
Schistosoma mansoni transient receptor potential channel 0.0197 0.425 1
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0551 0.86
Brugia malayi beta-lactamase family protein 0.0036 0.0637 0.1457
Echinococcus multilocularis transient receptor potential ion channel A 0.019 0.4102 0.9653
Loa Loa (eye worm) hypothetical protein 0.0015 0.0164 0.0375
Echinococcus granulosus thioredoxin glutathione reductase 0.0009 0.0022 0.0053
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0009 0.0022 0.0338
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0009 0.0022 0.0053
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1905 0.4484
Loa Loa (eye worm) hypothetical protein 0.0064 0.1265 0.2893
Loa Loa (eye worm) thioredoxin reductase 0.0009 0.0022 0.0051
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0261 0.3925
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0126 0.1898
Onchocerca volvulus 0.0028 0.0449 0.6937
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0261 0.3925
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0022 0.0338
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.1905 0.4359
Brugia malayi Latrophilin receptor protein 2 0.0064 0.1265 0.2893
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0193 0.2909
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0193 0.026
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0665 0.0977
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.057 0.8573
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Echinococcus multilocularis pyruvate kinase 0.0017 0.0198 0.0467
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0144 0.3052 0.4748
Onchocerca volvulus 0.0028 0.0449 0.6937
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0009 0.0022 0.0338
Schistosoma mansoni smad 0.0008 0.0016 0.0037
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0515 0.1213
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Echinococcus granulosus short transient receptor potential channel 6 0.013 0.2752 0.6476
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.1265 0.2893
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.057 0.0858
Plasmodium falciparum T-complex protein 1 subunit beta 0.0023 0.0352 0.0352
Plasmodium vivax thioredoxin reductase, putative 0.0009 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0015 0.0164 0.0375
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0261 0.0614
Brugia malayi T-complex protein 1, beta subunit 0.0023 0.0352 0.0806
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0009 0.0022 0.0338
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0193 0.2909
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0362 0.0362
Brugia malayi hypothetical protein 0.0015 0.0164 0.0375
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0561 0.0561
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0387 0.0387
Onchocerca volvulus 0.0015 0.0164 0.23
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.2598 0.5943
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0387 0.0554
Giardia lamblia Thioredoxin reductase 0.0144 0.3052 0.3973
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0202 0.4371 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.6403 1
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0023 0.0352 0.0352
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0022 0.0338
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0561 0.1283
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0551 0.0828
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Onchocerca volvulus 0.0015 0.0164 0.23
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0261 0.0787
Echinococcus multilocularis muscleblind protein 0.015 0.3188 0.7502
Trypanosoma brucei trypanothione reductase 0.0009 0.0022 0.0338
Leishmania major pyruvate kinase 0.0032 0.0551 0.8284
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0193 0.0193
Trichomonas vaginalis sugar transporter, putative 0.0033 0.057 0.0858
Echinococcus multilocularis solute carrier family 22 0.0015 0.0164 0.0385
Giardia lamblia Fructose-bisphosphate aldolase 0.0293 0.6403 0.8366
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0023 0.0352 0.0517
Schistosoma mansoni pyruvate kinase 0.0032 0.0551 0.1296
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0261 0.3925
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0261 0.0597
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0546 0.0714
Echinococcus granulosus dna polymerase kappa 0.0019 0.0261 0.0614
Echinococcus granulosus TRP transient receptor potential channel 0.0073 0.1472 0.3463
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0164 0.0385
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0261 0.3925
Echinococcus multilocularis short transient receptor potential channel 6 0.013 0.2752 0.6476
Echinococcus granulosus solute carrier family 22 0.0015 0.0164 0.0385
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0261 0.3925
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0637 0.1499
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.6403 0.8371
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0665 0.0665
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0078 0.0184
Trypanosoma cruzi hexose transporter 0.0033 0.057 0.8573
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0637 0.0637
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0261 0.0597
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0449 0.1027
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0022 0.0053
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0022 0.0053
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0362 0.544
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.6403 1
Brugia malayi MH2 domain containing protein 0.0123 0.2598 0.5943
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0551 0.8284
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0164 0.0385
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0073 0.1472 0.3463
Plasmodium falciparum pyruvate kinase 0.0032 0.0551 0.0551
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0009 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0036 0.0637 0.1457
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0198 0.0268
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0261 0.3925
Schistosoma mansoni disulfide oxidoreductase 0.0009 0.0022 0.0053
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0261 0.0787
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0362 0.112
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0665 0.0665
Schistosoma mansoni hypothetical protein 0.0064 0.1265 0.2976
Echinococcus granulosus solute carrier family 22 0.0015 0.0164 0.0385
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0202 0.4371 1
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0551 0.86
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0009 0.0022 0.0338
Brugia malayi Calcitonin receptor-like protein seb-1 0.0202 0.4371 1
Schistosoma mansoni pyruvate kinase 0.0017 0.0198 0.0467
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1905 0.4484
Leishmania major DNA polymerase kappa, putative 0.0019 0.0261 0.3925
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0164 0.0221
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0009 0.0022 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0261 0.3925
Giardia lamblia DINP protein human, muc B family 0.0019 0.0261 0.0313
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0637 0.1234
Onchocerca volvulus 0.0015 0.0164 0.23
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.0551 0.1061
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0023 0.0352 0.046
Trypanosoma brucei glucose transporter, putative 0.0033 0.057 0.8573
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Brugia malayi Transient-receptor-potential like protein 0.0073 0.1472 0.3367
Schistosoma mansoni glucose transport protein 0.0107 0.2224 0.5233
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0009 0.0022 0.0053
Brugia malayi glutathione reductase 0.0009 0.0022 0.0051
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Echinococcus granulosus GPCR family 2 0.0064 0.1265 0.2976
Schistosoma mansoni protein kinase 0.0033 0.0561 0.1319
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0551 0.126
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0164 0.0221
Echinococcus multilocularis solute carrier family 22 0.0015 0.0164 0.0385
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0009 0.0022 0.0338
Echinococcus multilocularis lamin dm0 0.0028 0.0449 0.1056
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0546 0.1284
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0261 0.3925
Entamoeba histolytica protein kinase, putative 0.0033 0.0561 0.0733
Echinococcus granulosus short transient receptor potential channel 6 0.013 0.2752 0.6476
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0193 0.0455
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0126 0.1898
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0261 0.3925
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0164 0.0385
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0022 0.0338
Plasmodium vivax pyruvate kinase, putative 0.0032 0.0551 0.0551
Entamoeba histolytica hypothetical protein 0.0037 0.0662 0.0865
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0561 0.0561
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Loa Loa (eye worm) hypothetical protein 0.0027 0.0437 0.1001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.1265 0.2976
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.3039 0.9957
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0561 0.1319
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Chlamydia trachomatis thioredoxin reductase 0.0144 0.3052 1
Mycobacterium leprae Probable lipase LipE 0.0036 0.0637 0.2028
Loa Loa (eye worm) beta-lactamase 0.0036 0.0637 0.1457
Loa Loa (eye worm) hypothetical protein 0.0015 0.0164 0.0375
Trypanosoma brucei glucose transporter, putative 0.0033 0.057 0.8573
Echinococcus multilocularis pyruvate kinase 0.0032 0.0551 0.1296
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0164 0.0284
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0546 0.0686
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0665 1
Schistosoma mansoni lamin 0.0028 0.0449 0.1056
Trichomonas vaginalis sugar transporter, putative 0.0033 0.057 0.0858
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0551 0.8284
Brugia malayi hypothetical protein 0.0015 0.0164 0.0375
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0198 0.0198
Plasmodium falciparum glutathione reductase 0.0009 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0009 0.0022 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0164 0.0221
Schistosoma mansoni glutamate synthase 0.0009 0.0022 0.0053
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.1265 0.2976
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0637 0.0963
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0665 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0662 0.1557
Brugia malayi hypothetical protein 0.0016 0.0188 0.0431
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Brugia malayi isocitrate dehydrogenase 0.0016 0.0193 0.0443
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0362 0.0851
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0261 0.3925
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0261 0.3925
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Schistosoma mansoni DNA polymerase eta 0.0019 0.0261 0.0614
Echinococcus granulosus General substrate transporter 0.0092 0.1887 0.444
Plasmodium falciparum thioredoxin reductase 0.0009 0.0022 0.0022
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0164 0.2462
Echinococcus multilocularis smad 0.0008 0.0016 0.0037
Loa Loa (eye worm) hypothetical protein 0.0036 0.0637 0.1457
Schistosoma mansoni hypothetical protein 0.0064 0.1265 0.2976
Echinococcus granulosus solute carrier family 22 0.0015 0.0164 0.0385
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Toxoplasma gondii sugar transporter ST3 0.0015 0.0164 0.0215
Entamoeba histolytica hypothetical protein 0.0099 0.2053 0.2683
Schistosoma mansoni protein kinase 0.0033 0.0561 0.1319
Brugia malayi Smad1 0.0008 0.0016 0.0036
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0164 0.0385
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0637 0.0963
Schistosoma mansoni protein kinase 0.0033 0.0561 0.1319
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0637 0.2028
Echinococcus granulosus pyruvate kinase 0.0017 0.0198 0.0467
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0561 0.1319
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0164 0.0375
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0449 0.1027
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.1265 0.2976
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0193 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0164 0.0221
Schistosoma mansoni glutamate synthase 0.0009 0.0022 0.0053
Onchocerca volvulus 0.0015 0.0164 0.23
Echinococcus multilocularis pyruvate kinase 0.0017 0.0198 0.0467
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0078 0.0184
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0261 0.0479
Loa Loa (eye worm) sugar transporter 0.0015 0.0164 0.0375
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0081 0.0091
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0144 0.3052 1
Entamoeba histolytica hypothetical protein 0.0024 0.0362 0.0473
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0198 0.0198
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0561 0.0561
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1905 0.4484
Plasmodium falciparum protein kinase 7 0.0301 0.6599 0.6599
Echinococcus granulosus lamin dm0 0.0028 0.0449 0.1056
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.6403 1
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0081 0.0192
Mycobacterium tuberculosis Conserved protein 0.0036 0.0637 0.1234
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0561 0.1319
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0261 0.3925
Brugia malayi intermediate filament protein 0.0028 0.0449 0.1027
Entamoeba histolytica hypothetical protein 0.0037 0.0662 0.0865
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0261 0.3925
Schistosoma mansoni intermediate filament proteins 0.0028 0.0449 0.1056
Giardia lamblia Sugar-proton symporter 0.0015 0.0164 0.0185
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0164 0.0385
Trypanosoma brucei unspecified product 0.0019 0.0261 0.3925
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0561 0.1319
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0261 0.0479
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0164 0.0221
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0261 0.0597
Brugia malayi MH1 domain containing protein 0.0008 0.0016 0.0036
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Trypanosoma brucei unspecified product 0.0013 0.0126 0.1898
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0009 0.0022 0.0338
Toxoplasma gondii facilitative glucose transporter GT1 0.0107 0.2224 0.3347
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0164 0.0375
Trichomonas vaginalis chaperonin, putative 0.0023 0.0352 0.0517
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0009 0.0022 0.0053
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0009 0.0022 0.0053
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0009 0.0022 0.0338
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0261 0.3925
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0637 0.1234
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0164 0.0466
Brugia malayi major facilitator superfamily protein 0.0015 0.0164 0.0375
Trypanosoma cruzi trypanothione reductase, putative 0.0009 0.0022 0.0338
Echinococcus granulosus calcium activated potassium channel 0.0009 0.002 0.0047
Onchocerca volvulus 0.0015 0.0164 0.23
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0352 0.0829
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.0022 0.0051
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2224 0.5233
Toxoplasma gondii t-complex protein beta subunit 0.0023 0.0352 0.0501
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0023 0.0352 0.0829
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0022 0.0338
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0009 0.0022 0.0029
Trypanosoma brucei NADH dehydrogenase 0.0009 0.0022 0.0338
Loa Loa (eye worm) pyruvate kinase-PB 0.0022 0.0332 0.0759
Brugia malayi MH2 domain containing protein 0.0008 0.0016 0.0036
Schistosoma mansoni sugar transporter 0.0015 0.0164 0.0385
Plasmodium vivax hexose transporter 0.0107 0.2224 0.2224
Schistosoma mansoni glutamate synthase 0.0009 0.0022 0.0053
Mycobacterium ulcerans pyruvate kinase 0.0032 0.0551 0.1744
Mycobacterium ulcerans sugar transporter 0.0015 0.0164 0.0466
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0551 0.86
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0193 0.0455
Onchocerca volvulus Putative transporter 0.0015 0.0164 0.23
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0637 0.1499
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0261 0.3925
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2224 0.5233
Chlamydia trachomatis pyruvate kinase 0.0032 0.0551 0.1744
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Leishmania major NADH dehydrogenase, putative 0.0009 0.0022 0.0338
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0637 0.0963
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0144 0.3052 1
Giardia lamblia Hexose transporter 0.0015 0.0164 0.0185
Trypanosoma brucei glucose transporter, putative 0.0033 0.057 0.8573
Toxoplasma gondii protein kinase, putative 0.0301 0.6599 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0637 0.9578
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0016 0.0037
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0637 0.2028
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0261 0.3925
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0193 0.2909
Echinococcus granulosus muscleblind protein 0.015 0.3188 0.7502
Echinococcus multilocularis pyruvate kinase 0.0032 0.0551 0.1296
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Loa Loa (eye worm) hypothetical protein 0.0022 0.0332 0.0759
Trypanosoma brucei hypothetical protein, conserved 0.0009 0.0022 0.0338
Onchocerca volvulus 0.0015 0.0164 0.23
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0665 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0193 0.0455
Trypanosoma brucei unspecified product 0.0013 0.0126 0.1898
Brugia malayi Muscleblind-like protein 0.015 0.3188 0.7294
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0022 0.0053
Schistosoma mansoni transient receptor potential channel 0.013 0.2752 0.6476
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0352 0.0829
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0546 0.082
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0561 0.1319
Giardia lamblia TCP-1 chaperonin subunit beta 0.0023 0.0352 0.0432
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0022 0.0053
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.0551 0.8284
Onchocerca volvulus 0.0015 0.0164 0.23
Echinococcus multilocularis glutamate synthase 0.0009 0.0022 0.0053
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0662 0.1557
Brugia malayi hypothetical protein 0.0015 0.0164 0.0375
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.057 0.8573
Echinococcus granulosus pyruvate kinase 0.0017 0.0198 0.0467
Treponema pallidum fructose-bisphosphate aldolase 0.0293 0.6403 1
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0515 0.1213
Brugia malayi beta-lactamase 0.0036 0.0637 0.1457
Echinococcus multilocularis solute carrier family 22 0.0015 0.0164 0.0385
Plasmodium vivax CDK-related protein kinase 6, putative 0.0453 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0261 0.3925
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0561 0.0561
Loa Loa (eye worm) hypothetical protein 0.0013 0.0127 0.029
Echinococcus granulosus transient receptor potential gamma protein 0.0197 0.425 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2224 0.5233
Schistosoma mansoni smad1 5 8 and 0.0008 0.0016 0.0037
Plasmodium vivax glutathione reductase, putative 0.0009 0.0022 0.0022
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0551 0.126
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0352 0.0829
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0009 0.0022 0.0053
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.6403 0.8371
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.0036 0.0637 0.1457
Plasmodium vivax sugar transporter, putative 0.0015 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0015 0.0164 0.0375
Leishmania major glucose transporter, lmgt2 0.0033 0.057 0.8573
Trypanosoma brucei glucose transporter, putative 0.0033 0.057 0.8573
Entamoeba histolytica pyruvate kinase, putative 0.0022 0.0332 0.0434
Trypanosoma brucei glucose transporter, putative 0.0033 0.057 0.8573
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0193 0.0455
Echinococcus multilocularis pyruvate kinase 0.0025 0.0398 0.0937
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0637 0.1234
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0637 0.1457
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0009 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0015 0.0164 0.0375
Loa Loa (eye worm) hypothetical protein 0.0015 0.0164 0.0375
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0009 0.0022 0.0051
Loa Loa (eye worm) hypothetical protein 0.0032 0.0546 0.1249
Mycobacterium ulcerans lipase LipD 0.0036 0.0637 0.2028
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0561 0.1319
Echinococcus granulosus glutamate synthase 0.0009 0.0022 0.0053
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0281 0.0519
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0009 0.0022 0.0022
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0561 0.0561
Trypanosoma cruzi NADH dehydrogenase, putative 0.0009 0.0022 0.0338
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0193 0.0343
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.0081 0.0192
Echinococcus granulosus pyruvate kinase 0.0017 0.0198 0.0467
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0193 0.0443
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1905 0.4484
Loa Loa (eye worm) hypothetical protein 0.0033 0.0561 0.1283
Echinococcus multilocularis Smad4 0.0008 0.0016 0.0037
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0009 0.0022 0.0338
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1905 0.4484
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0122 0.0279
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0164 0.0221
Onchocerca volvulus 0.0036 0.0637 1
Schistosoma mansoni lamin 0.0028 0.0449 0.1056
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0009 0.0022 0.0022
Loa Loa (eye worm) sugar transporter 0.0107 0.2224 0.5087
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0009 0.0022 0.0338
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0561 0.0561
Loa Loa (eye worm) hypothetical protein 0.0015 0.0164 0.0375
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0637 0.1499
Mycobacterium ulcerans beta-lactamase 0.0036 0.0637 0.2028
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0144 0.3052 0.4748
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0009 0.0022 0.0053
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0561 0.1319
Echinococcus multilocularis calcium activated potassium channel 0.0009 0.002 0.0047
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0261 0.0374
Toxoplasma gondii ABC1 family protein 0.0036 0.0637 0.0934
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0561 0.0819
Leishmania major glucose transporter, lmgt3 0.0033 0.057 0.8573
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0362 0.0828
Brugia malayi Sugar transporter family protein 0.0015 0.0164 0.0375
Echinococcus granulosus dna polymerase eta 0.0019 0.0261 0.0614
Loa Loa (eye worm) hypothetical protein 0.0036 0.0637 0.1457
Brugia malayi MH1 domain containing protein 0.0008 0.0016 0.0036

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 390 nM Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells ChEMBL. 15837330
Ki (binding) = 390 nM Inhibitory constant against human Bradykinin receptor B1 expressed in chinese hamster ovary cells ChEMBL. 15837330
T1/2 (ADMET) 0 hr Half life of the compound in the Sprague ChEMBL. 15837330

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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