Detailed information for compound 342855

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 660.927 | Formula: C27H48N4O9SSi2
  • H donors: 2 H acceptors: 5 LogP: 2.62 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CNC(=O)Cn1c(=O)n(cc(c1=O)C)C1OC(C2(C1O[Si](C(C)(C)C)(C)C)OS(=O)(=O)C=C2N)CO[Si](C(C)(C)C)(C)C
  • InChi: 1S/C27H48N4O9SSi2/c1-17-13-31(24(34)30(22(17)33)14-20(32)29-8)23-21(39-43(11,12)26(5,6)7)27(18(28)16-41(35,36)40-27)19(38-23)15-37-42(9,10)25(2,3)4/h13,16,19,21,23H,14-15,28H2,1-12H3,(H,29,32)
  • InChiKey: AKMPBIVPSYUYES-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0146 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.1374 0.5044 0.5044
Onchocerca volvulus 0.0073 0.0138 0.0514
Loa Loa (eye worm) hypothetical protein 0.0138 0.0381 0.0381
Echinococcus granulosus g protein coupled receptor 0.0073 0.0138 0.0255
Loa Loa (eye worm) hypothetical protein 0.0098 0.0231 0.0231
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0138 0.0381 0.0381
Schistosoma mansoni steroid hormone receptor ad4bp 0.0147 0.0415 0.1523
Loa Loa (eye worm) hypothetical protein 0.0138 0.0381 0.0381
Brugia malayi Carboxylesterase family protein 0.0072 0.0135 0.0135
Echinococcus multilocularis fmrfamide receptor 0.0073 0.0138 0.0268
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0073 0.0138 0.0268
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0138 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0515 0.1804 0.1804
Echinococcus granulosus ecdysone induced protein 78C 0.0147 0.0415 0.0766
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0051 0.0053 0.5
Schistosoma mansoni coup transcription factor 0.0147 0.0415 0.1523
Echinococcus granulosus sex peptide receptor 0.0073 0.0138 0.0255
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0069 0.0123 0.0239
Loa Loa (eye worm) hypothetical protein 0.0138 0.0381 0.0381
Echinococcus multilocularis serotonin receptor 0.0073 0.0138 0.0268
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Brugia malayi Serine carboxypeptidase S28 family protein 0.0099 0.0236 0.0236
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0138 0.0506
Mycobacterium leprae conserved hypothetical protein 0.0082 0.0171 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0073 0.0138 0.0268
Loa Loa (eye worm) hypothetical protein 0.0147 0.0415 0.0415
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0298 0.0987 0.3622
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.015 0.0429 0.0792
Echinococcus granulosus nuclear receptor nhr 48 0.0069 0.0123 0.0227
Onchocerca volvulus 0.0298 0.0987 0.3674
Trichomonas vaginalis set domain proteins, putative 0.0516 0.1809 1
Brugia malayi conserved hypotetical protein 0.0069 0.0123 0.0123
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0073 0.0138 0.0268
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0298 0.0987 0.0987
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Echinococcus granulosus nAChR subunit 0.0161 0.0468 0.0864
Loa Loa (eye worm) latrophilin receptor protein 2 0.0098 0.0231 0.0231
Brugia malayi latrophilin 2 splice variant baaae 0.0211 0.0659 0.0659
Loa Loa (eye worm) serotonin transporter b 0.0146 0.0413 0.0413
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0138 0.0255
Echinococcus granulosus 7TM GPCR rhodopsin 0.0073 0.0138 0.0255
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0298 0.0987 0.1919
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0073 0.0138 0.0506
Loa Loa (eye worm) hypothetical protein 0.0077 0.0154 0.0154
Onchocerca volvulus 0.0138 0.0381 0.1418
Mycobacterium ulcerans hypothetical protein 0.0169 0.0499 1
Loa Loa (eye worm) steroid hormone receptor 0.0147 0.0415 0.0415
Schistosoma mansoni neuropeptide f receptor 76f 0.0073 0.0138 0.0506
Onchocerca volvulus 0.0073 0.0138 0.0514
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0298 0.0987 0.1821
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0298 0.0987 0.1919
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0161 0.0468 0.1718
Loa Loa (eye worm) hypothetical protein 0.0138 0.0381 0.0381
Echinococcus granulosus FTZ F1 alpha 0.0147 0.0415 0.0766
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0138 0.0381 0.0381
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0069 0.0123 0.0239
Echinococcus granulosus glutamate receptor NMDA 0.0253 0.0815 0.1504
Onchocerca volvulus 0.0161 0.0468 0.1742
Brugia malayi Cytochrome P450 family protein 0.0078 0.0157 0.0157
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0147 0.0415 0.0807
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0138 0.0255
Echinococcus granulosus survival motor neuron protein 1 0.026 0.0843 0.1556
Schistosoma mansoni hypothetical protein 0.0532 0.1868 0.6856
Echinococcus multilocularis thyroid hormone receptor alpha 0.0147 0.0415 0.0807
Schistosoma mansoni nuclear receptor nhr-48 0.0069 0.0123 0.0451
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0098 0.0231 0.0449
Leishmania major hypothetical protein, conserved 0.0133 0.0365 0.0365
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0073 0.0138 0.0138
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0147 0.0415 0.0415
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0138 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0147 0.0415 0.0415
Echinococcus granulosus nAChR subunit 0.0298 0.0987 0.1821
Brugia malayi nuclear receptor RXR 0.0077 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0298 0.0987 0.0987
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0133 0.0365 0.0365
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0199 0.0614 0.1194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0147 0.0415 0.0415
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0298 0.0987 0.1821
Echinococcus granulosus tm gpcr rhodopsin 0.0073 0.0138 0.0255
Echinococcus multilocularis nAChR subunit 0.0161 0.0468 0.091
Echinococcus multilocularis glutamate receptor 2 0.0197 0.0604 0.1174
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0233 0.0742 0.1442
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.037 0.1257 0.1257
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0161 0.0468 0.0468
Echinococcus granulosus orexin receptor type 2 0.0073 0.0138 0.0255
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0073 0.0138 0.0268
Loa Loa (eye worm) hypothetical protein 0.0298 0.0987 0.0987
Schistosoma mansoni nAChR subunit 0.0138 0.0381 0.1398
Loa Loa (eye worm) nuclear hormone receptor 0.0069 0.0123 0.0123
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0073 0.0138 0.0138
Schistosoma mansoni biogenic amine (5HT) receptor 0.0073 0.0138 0.0506
Trypanosoma cruzi Emopamil binding protein, putative 0.0133 0.0365 0.0365
Schistosoma mansoni myosin xvIII 0.0073 0.0138 0.0506
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0147 0.0415 0.0807
Schistosoma mansoni hypothetical protein 0.0395 0.1353 0.4964
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0053 0.0104
Schistosoma mansoni hypothetical protein 0.0098 0.0231 0.0848
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0147 0.0415 0.1523
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0171 0.0171
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0523 0.1835 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0051 0.0053 0.0053
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0069 0.0123 0.0458
Schistosoma mansoni nAChR subunit 0.0298 0.0987 0.3622
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0073 0.0138 0.0506
Echinococcus granulosus neuropeptide FF receptor 2 0.0073 0.0138 0.0255
Schistosoma mansoni neuropeptide receptor 0.0073 0.0138 0.0506
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0138 0.0268
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Schistosoma mansoni biogenic amine receptor 0.0073 0.0138 0.0506
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.0109 0.0213
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0079 0.016 0.016
Leishmania major C-14 sterol reductase, putative 0.0088 0.0195 0.0195
Echinococcus multilocularis neuropeptide receptor 0.0222 0.0701 0.1363
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0147 0.0415 0.0766
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Onchocerca volvulus 0.0069 0.0123 0.0458
Echinococcus granulosus glycine receptor subunit alpha 1 0.0298 0.0987 0.1821
Loa Loa (eye worm) hypothetical protein 0.0147 0.0415 0.0415
Echinococcus granulosus 7tm_1 domain containing protein 0.0073 0.0138 0.0255
Brugia malayi hypothetical protein 0.0073 0.0138 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0138 0.0506
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0069 0.0123 0.0239
Onchocerca volvulus 0.0138 0.0381 0.1418
Loa Loa (eye worm) hypothetical protein 0.0147 0.0415 0.0415
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0147 0.0415 0.0415
Echinococcus multilocularis lamin b receptor 0.0088 0.0195 0.038
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0073 0.0138 0.0138
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0079 0.016 0.0312
Schistosoma mansoni ATP-binding cassette transporter 0.0197 0.0604 0.2216
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0233 0.0742 0.1442
Schistosoma mansoni biogenic amine receptor 0.0073 0.0138 0.0506
Echinococcus multilocularis somatostatin receptor 0.0073 0.0138 0.0268
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0073 0.0138 0.0506
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0298 0.0987 0.0987
Brugia malayi Pre-SET motif family protein 0.0454 0.1573 0.1573
Loa Loa (eye worm) hypothetical protein 0.0298 0.0987 0.0987
Entamoeba histolytica hypothetical protein 0.0161 0.0468 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0171 0.0171
Onchocerca volvulus 0.0147 0.0415 0.1545
Plasmodium vivax hypothetical protein, conserved 0.0082 0.0171 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0298 0.0987 0.0987
Loa Loa (eye worm) hypothetical protein 0.0069 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0211 0.0659 0.0659
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0077 0.0154 0.0566
Schistosoma mansoni hypothetical protein 0.0073 0.0138 0.0506
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0112 0.041
Trypanosoma cruzi C-14 sterol reductase, putative 0.0088 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0147 0.0415 0.0415
Loa Loa (eye worm) solute carrier family 6 member 4 0.0146 0.0413 0.0413
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0101 0.0243 0.0892
Loa Loa (eye worm) G-protein coupled receptor 0.0073 0.0138 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0138 0.0506
Onchocerca volvulus 0.0073 0.0138 0.0514
Echinococcus multilocularis g-protein coupled receptor 0.0073 0.0138 0.0268
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0298 0.0987 0.0987
Trypanosoma cruzi sterol C-24 reductase, putative 0.0046 0.0035 0.0035
Mycobacterium tuberculosis Conserved protein 0.0082 0.0171 0.0659
Echinococcus multilocularis glutamate receptor NMDA 0.0253 0.0815 0.1584
Loa Loa (eye worm) hypothetical protein 0.2687 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0069 0.0123 0.0458
Onchocerca volvulus 0.0066 0.0109 0.0407
Loa Loa (eye worm) glutamate receptor 1 0.0197 0.0604 0.0604
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0046 0.0035 0.0035
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0062 0.0062
Echinococcus granulosus neuropeptide Y receptor 0.0073 0.0138 0.0255
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0073 0.0138 0.0138
Brugia malayi hypothetical protein 0.0073 0.0138 0.0138
Brugia malayi Nuclear hormone receptor-like 1 0.0147 0.0415 0.0415
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0147 0.0415 0.0415
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0298 0.0987 0.0987
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0101 0.0243 0.0449
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0147 0.0415 0.0415
Brugia malayi Abnormal catecholamine distribution protein 1 0.037 0.1257 0.1257
Echinococcus granulosus fmrfamide receptor 0.0073 0.0138 0.0255
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0298 0.0987 0.0987
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0425 0.1466 0.1466
Onchocerca volvulus TPPP family protein homolog 0.0749 0.2687 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0169 0.0499 0.2503
Echinococcus granulosus glutamate receptor 2 0.0233 0.0742 0.1369
Echinococcus granulosus acetylcholinesterase 0.0072 0.0135 0.0249
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0073 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0161 0.0468 0.0468
Brugia malayi nuclear receptor RXR 0.0069 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0298 0.0987 0.0987
Loa Loa (eye worm) hypothetical protein 0.0069 0.0123 0.0123
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0077 0.0154 0.0285
Brugia malayi Cation transporter family protein 0.0298 0.0987 0.0987
Loa Loa (eye worm) hypothetical protein 0.0161 0.0468 0.0468
Brugia malayi isocitrate dehydrogenase 0.0051 0.0053 0.0053
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0138 0.0268
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Brugia malayi AKH receptor 0.0073 0.0138 0.0138
Echinococcus granulosus glycine receptor subunit beta 0.0298 0.0987 0.1821
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0161 0.0468 0.0468
Loa Loa (eye worm) hypothetical protein 0.0161 0.0468 0.0468
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0101 0.0243 0.0449
Onchocerca volvulus Bile acid receptor homolog 0.0147 0.0415 0.1545
Echinococcus multilocularis isocitrate dehydrogenase 0.0051 0.0053 0.0104
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0073 0.0138 0.0255
Echinococcus multilocularis orexin receptor type 2 0.0073 0.0138 0.0268
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0138 0.0506
Brugia malayi tailless protein 0.0069 0.0123 0.0123
Brugia malayi Pre-SET motif family protein 0.0066 0.0109 0.0109
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0109 0.2955
Schistosoma mansoni adenoreceptor 0.0073 0.0138 0.0506
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0298 0.0987 0.1821
Onchocerca volvulus 0.0073 0.0138 0.0514
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0298 0.0987 0.0987
Echinococcus multilocularis fmrfamide receptor 0.0073 0.0138 0.0268
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0073 0.0138 0.0506
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0138 0.0506
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0073 0.0138 0.0268
Onchocerca volvulus 0.0298 0.0987 0.3674
Loa Loa (eye worm) hypothetical protein 0.0138 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Schistosoma mansoni thyroid hormone receptor 0.0147 0.0415 0.1523
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Loa Loa (eye worm) cytochrome P450 family protein 0.0078 0.0157 0.0157
Schistosoma mansoni biogenic amine (5HT) receptor 0.0073 0.0138 0.0506
Schistosoma mansoni glutamate receptor NMDA 0.0491 0.1715 0.6294
Echinococcus multilocularis neuropeptide s receptor 0.0073 0.0138 0.0268
Echinococcus multilocularis geminin 0.0532 0.1868 0.3633
Brugia malayi nuclear hormone receptor family member nhr-6 0.0069 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0161 0.0468 0.0468
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0147 0.0415 0.0415
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0072 0.0135 0.0495
Echinococcus granulosus GPCR family 2 0.0098 0.0231 0.0426
Echinococcus granulosus neuropeptides capa receptor 0.0073 0.0138 0.0255
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0309 0.1028 0.1028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0147 0.0415 0.0807
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0073 0.0138 0.0268
Schistosoma mansoni retinoic acid receptor RXR 0.0147 0.0415 0.1523
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0109 0.0402
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0298 0.0987 0.0987
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0147 0.0415 0.1523
Echinococcus multilocularis neuropeptide receptor 0.0073 0.0138 0.0268
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0146 0.0413 0.0413
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0321 0.1072 0.1072
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0298 0.0987 0.3622
Loa Loa (eye worm) hypothetical protein 0.0077 0.0154 0.0154
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0077 0.0154 0.0566
Loa Loa (eye worm) neuropeptide F receptor 0.0073 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0069 0.0123 0.0123
Onchocerca volvulus 0.0516 0.1809 0.6734
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0233 0.0742 0.1442
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0298 0.0987 0.1919
Loa Loa (eye worm) hypothetical protein 0.0147 0.0415 0.0415
Echinococcus multilocularis neuropeptide FF receptor 2 0.0073 0.0138 0.0268
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0147 0.0415 0.0807
Echinococcus multilocularis nuclear receptor nhr 48 0.0069 0.0123 0.0239
Brugia malayi Dopamine receptor 0.0073 0.0138 0.0138
Trypanosoma cruzi sterol C-24 reductase, putative 0.0046 0.0035 0.0035
Echinococcus multilocularis acetylcholinesterase 0.0072 0.0135 0.0262
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0112 0.0217
Loa Loa (eye worm) hypothetical protein 0.0082 0.0171 0.0171
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0051 0.0053 0.0098
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0069 0.0123 0.0451
Schistosoma mansoni hypothetical protein 0.0073 0.0138 0.0506
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0069 0.0069
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0138 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0069 0.0123 0.0123
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0051 0.0053 0.0053
Echinococcus granulosus neuropeptide Y receptor 0.0073 0.0138 0.0255
Brugia malayi steroid hormone receptor 0.0147 0.0415 0.0415
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0073 0.0138 0.0514
Loa Loa (eye worm) hypothetical protein 0.0072 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0138 0.0381 0.0381
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0298 0.0987 0.0987
Loa Loa (eye worm) hypothetical protein 0.0069 0.0123 0.0123
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0051 0.0053 0.0021
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0073 0.0138 0.0255
Schistosoma mansoni opsin-like receptor 0.0073 0.0138 0.0506
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Schistosoma mansoni glutamate receptor NMDA 0.0486 0.1695 0.6219
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0098 0.0231 0.0449
Brugia malayi RE15519p 0.0073 0.0138 0.0138
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0138 0.0268
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Echinococcus granulosus microtubule associated protein 2 0.0759 0.2725 0.5029
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0298 0.0987 0.3622
Echinococcus multilocularis G-protein coupled receptor, putative 0.0073 0.0138 0.0268
Onchocerca volvulus 0.0146 0.0413 0.1537
Schistosoma mansoni opsin-like receptor 0.0073 0.0138 0.0506
Brugia malayi putative neuropeptide receptor NPR1 0.0073 0.0138 0.0138
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0073 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0298 0.0987 0.0987
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0073 0.0138 0.0255
Loa Loa (eye worm) hypothetical protein 0.0072 0.0135 0.0135
Echinococcus multilocularis survival motor neuron protein 1 0.026 0.0843 0.1639
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0147 0.0415 0.1523
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0073 0.0138 0.0506
Echinococcus multilocularis neuropeptide Y receptor 0.0073 0.0138 0.0268
Trypanosoma brucei Emopamil binding protein, putative 0.0133 0.0365 0.0334
Loa Loa (eye worm) hypothetical protein 0.0515 0.1804 0.1804
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0138 0.0268
Brugia malayi follicle stimulating hormone receptor 0.0073 0.0138 0.0138
Schistosoma mansoni nAChR subunit 0.0298 0.0987 0.3622
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Schistosoma mansoni alpha-1 adrenergic receptor 0.0073 0.0138 0.0506
Brugia malayi putative neuropeptide receptor 0.0073 0.0138 0.0138
Echinococcus granulosus glutamate receptor 2 0.0135 0.0373 0.0689
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0147 0.0415 0.0415
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0298 0.0987 0.0987
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0073 0.0138 0.0268
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Brugia malayi orphan nuclear receptor NR2E1 0.0069 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0138 0.0381 0.0381
Schistosoma mansoni histamine h1 receptor 0.0073 0.0138 0.0506
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0098 0.0231 0.0426
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0077 0.0154 0.03
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0233 0.0742 0.1369
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0298 0.0987 0.0987
Loa Loa (eye worm) hypothetical protein 0.0298 0.0987 0.0987
Mycobacterium ulcerans beta-lactamase 0.0082 0.0171 0.1525
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0138 0.0381 0.0381
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.015 0.0429 0.0834
Echinococcus granulosus peptide allatostatin:somatostatin 0.0073 0.0138 0.0255
Echinococcus granulosus geminin 0.0532 0.1868 0.3448
Echinococcus granulosus thyroid hormone receptor alpha 0.0069 0.0123 0.0227
Brugia malayi nuclear hormone receptor 0.0147 0.0415 0.0415
Echinococcus granulosus dro:myosuppressin receptor 0.0073 0.0138 0.0255
Brugia malayi hypothetical protein 0.0138 0.0381 0.0381
Schistosoma mansoni acetylcholine receptor subunit beta 0.0138 0.0381 0.1398
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0147 0.0415 0.1523
Echinococcus granulosus beta LACTamase domain containing family member 0.0082 0.0171 0.0315
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0073 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0298 0.0987 0.0987
Schistosoma mansoni hypothetical protein 0.0073 0.0138 0.0506
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0298 0.0987 0.0987
Loa Loa (eye worm) melatonin receptor type 1A 0.0073 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0298 0.0987 0.0987
Echinococcus multilocularis FTZ F1 alpha 0.0147 0.0415 0.0807
Echinococcus granulosus serotonin transporter 0.0146 0.0413 0.0762
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0161 0.0468 0.0468
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0138 0.0255
Mycobacterium ulcerans lipase LipD 0.0082 0.0171 0.1525
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0073 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Trypanosoma cruzi C-8 sterol isomerase, putative 0.2687 1 1
Echinococcus granulosus lamin b receptor 0.0088 0.0195 0.0361
Echinococcus multilocularis ecdysone induced protein 78C 0.0147 0.0415 0.0807
Echinococcus granulosus biogenic amine 5HT receptor 0.0073 0.0138 0.0255
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Brugia malayi Melatonin receptor type 1A 0.0073 0.0138 0.0138
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0073 0.0138 0.0506
Onchocerca volvulus 0.0298 0.0987 0.3674
Brugia malayi neuropeptide F receptor 0.0073 0.0138 0.0138
Mycobacterium tuberculosis Conserved protein 0.0082 0.0171 0.0659
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0147 0.0415 0.0415
Brugia malayi Glutamate receptor 2 precursor 0.0197 0.0604 0.0604
Schistosoma mansoni amine GPCR 0.0073 0.0138 0.0506
Echinococcus multilocularis neuropeptide Y receptor 0.0073 0.0138 0.0268
Loa Loa (eye worm) hypothetical protein 0.0161 0.0468 0.0468
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0098 0.0231 0.0449
Echinococcus multilocularis carboxylesterase 5A 0.0072 0.0135 0.0262
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0596 0.2109 0.41
Schistosoma mansoni nuclear receptor 0.0069 0.0123 0.0451
Loa Loa (eye worm) hypothetical protein 0.0069 0.0123 0.0123
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0138 0.0381 0.0703
Echinococcus multilocularis nmda type glutamate receptor 0.0289 0.0953 0.1853
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0138 0.0381 0.0741
Schistosoma mansoni survival motor neuron protein 0.0053 0.0062 0.0228
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0073 0.0138 0.0268
Brugia malayi nuclear hormone receptor family member odr-7 0.0069 0.0123 0.0123
Echinococcus granulosus glycine receptor subunit alpha 1 0.0298 0.0987 0.1821
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0073 0.0138 0.0506
Leishmania major mitochondrial DNA polymerase beta 0.0321 0.1072 0.1072
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0073 0.0138 0.0268
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0053 0.0021
Brugia malayi hypothetical protein 0.0073 0.0138 0.0138
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0298 0.0987 0.1919
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0138 0.0268
Brugia malayi Cation transporter family protein 0.0298 0.0987 0.0987
Mycobacterium tuberculosis Conserved protein 0.0082 0.0171 0.0659
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0099 0.0236 0.046
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0098 0.0231 0.0426
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0298 0.0987 0.1821
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0146 0.0413 0.0413
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0098 0.0231 0.0231
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0098 0.0231 0.0426
Loa Loa (eye worm) hypothetical protein 0.0425 0.1466 0.1466
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0147 0.0415 0.0415
Brugia malayi hypothetical protein 0.0069 0.0123 0.0123
Trypanosoma brucei C-14 sterol reductase, putative 0.0088 0.0195 0.0164
Onchocerca volvulus 0.0073 0.0138 0.0514
Loa Loa (eye worm) hypothetical protein 0.0161 0.0468 0.0468
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0491 0.1715 0.3335
Echinococcus multilocularis serotonin transporter 0.0146 0.0413 0.0803
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0069 0.0123 0.0239
Loa Loa (eye worm) acetylcholine receptor protein 0.0138 0.0381 0.0381
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0298 0.0987 0.0987
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0102 0.0245 0.3449
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0298 0.0987 0.0987
Echinococcus granulosus synaptic vesicular amine transporter 0.037 0.1257 0.232
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0309 0.1028 0.1028
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0112 0.0206
Brugia malayi Cation transporter family protein 0.0298 0.0987 0.0987
Schistosoma mansoni nuclear hormone receptor 0.0069 0.0123 0.0451
Onchocerca volvulus 0.0082 0.0171 0.0636
Loa Loa (eye worm) hypothetical protein 0.0147 0.0415 0.0415
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0082 0.0171 0.0659
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0147 0.0415 0.1523
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0112 0.3077
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0073 0.0138 0.0268
Loa Loa (eye worm) hypothetical protein 0.0298 0.0987 0.0987
Loa Loa (eye worm) hypothetical protein 0.0147 0.0415 0.0415
Echinococcus multilocularis GPCR, family 2 0.0098 0.0231 0.0449
Echinococcus granulosus g-protein coupled receptor 0.0073 0.0138 0.0255
Schistosoma mansoni nAChR subunit 0.0298 0.0987 0.3622
Loa Loa (eye worm) acetylcholinesterase 1 0.0072 0.0135 0.0135
Schistosoma mansoni hypothetical protein 0.0098 0.0231 0.0847
Onchocerca volvulus 0.0161 0.0468 0.1742
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0098 0.0231 0.0449
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0298 0.0987 0.1919
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0073 0.0138 0.0506
Echinococcus multilocularis conserved hypothetical protein 0.14 0.5143 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0138 0.0506
Brugia malayi hypothetical protein 0.0073 0.0138 0.0138
Brugia malayi G protein-coupled receptor 0.0073 0.0138 0.0138
Brugia malayi Serotonin receptor 0.1006 0.3658 0.3658
Echinococcus multilocularis g protein coupled receptor 0.0073 0.0138 0.0268
Loa Loa (eye worm) hypothetical protein 0.0298 0.0987 0.0987
Loa Loa (eye worm) hypothetical protein 0.0138 0.0381 0.0381
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0233 0.0742 0.1369
Brugia malayi nuclear receptor NHR-88 0.0069 0.0123 0.0123
Leishmania major sterol C-24 reductase, putative 0.0046 0.0035 0.0035
Echinococcus granulosus Nuclear hormone receptor HR96 0.0069 0.0123 0.0227
Echinococcus multilocularis synaptic vesicular amine transporter 0.037 0.1257 0.2445
Toxoplasma gondii ABC1 family protein 0.0082 0.0171 0.6191
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0298 0.0987 0.1919
Treponema pallidum sodium- and chloride- dependent transporter 0.0146 0.0413 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0098 0.0231 0.0449
Echinococcus granulosus g protein coupled receptor 0.0073 0.0138 0.0255
Echinococcus multilocularis nAChR subunit 0.0298 0.0987 0.1919
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0069 0.0123 0.0451
Echinococcus granulosus glycine receptor subunit beta 0.0298 0.0987 0.1821
Schistosoma mansoni hypothetical protein 0.0098 0.0231 0.0848
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Mycobacterium leprae Probable lipase LipE 0.0082 0.0171 0.5
Echinococcus granulosus neuropeptide receptor 0.0222 0.0701 0.1293
Trypanosoma brucei C-8 sterol isomerase, putative 0.2687 1 1
Brugia malayi Nuclear hormone receptor E75 0.0069 0.0123 0.0123
Schistosoma mansoni nAChR subunit 0.0298 0.0987 0.3622
Schistosoma mansoni neurotransmitter gated ion channel 0.0138 0.0381 0.1398
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0082 0.0171 0.0659
Schistosoma mansoni glutamate receptor kainate 0.0197 0.0604 0.2216
Loa Loa (eye worm) hypothetical protein 0.0138 0.0381 0.0381
Echinococcus granulosus hypothetical protein 0.1473 0.5419 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0109 0.0402
Schistosoma mansoni amine GPCR 0.0073 0.0138 0.0506
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0321 0.1072 0.1072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0147 0.0415 0.0415
Loa Loa (eye worm) hypothetical protein 0.0082 0.0171 0.0171
Brugia malayi hypothetical protein 0.0077 0.0154 0.0154
Schistosoma mansoni glutamate receptor kainate 0.0197 0.0604 0.2216
Schistosoma mansoni neuropeptide F-like receptor 0.0073 0.0138 0.0506
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0098 0.0231 0.0426
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0138 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0069 0.0123 0.0123
Onchocerca volvulus 0.0082 0.0171 0.0636
Echinococcus granulosus allatostatin A receptor 0.0073 0.0138 0.0255
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0051 0.0053 0.0104
Schistosoma mansoni nuclear receptor 0.0069 0.0123 0.0451
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0138 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0069 0.0123 0.0227
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0133 0.0365 0.0365
Onchocerca volvulus 0.0073 0.0138 0.0514
Loa Loa (eye worm) hypothetical protein 0.0069 0.0123 0.0123
Onchocerca volvulus 0.0073 0.0138 0.0514
Schistosoma mansoni nAChR subunit 0.0138 0.0381 0.1398
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0147 0.0415 0.0415
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0073 0.0138 0.0506
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Loa Loa (eye worm) neuropeptide F receptor 0.0073 0.0138 0.0138
Schistosoma mansoni amine GPCR 0.0073 0.0138 0.0506
Mycobacterium ulcerans hypothetical protein 0.0082 0.0171 0.1525
Loa Loa (eye worm) hypothetical protein 0.0099 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Schistosoma mansoni hypothetical protein 0.01 0.0239 0.0878
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Trypanosoma brucei hypothetical protein, conserved 0.0082 0.0171 0.0139
Echinococcus multilocularis nmda type glutamate receptor 0.0452 0.1567 0.3047
Schistosoma mansoni opsin-like receptor 0.0073 0.0138 0.0506
Brugia malayi G protein-coupled receptor F59B2.13 0.0073 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0298 0.0987 0.0987
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0138 0.0381 0.0741
Loa Loa (eye worm) hypothetical protein 0.0403 0.1384 0.1384
Brugia malayi hypothetical protein 0.0073 0.0138 0.0138
Echinococcus multilocularis microtubule associated protein 2 0.0759 0.2725 0.5299
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.0435 0.0435
Brugia malayi GnHR receptor homolog 0.0073 0.0138 0.0138
Schistosoma mansoni nuclear hormone receptor 0.0147 0.0415 0.1523
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0298 0.0987 0.1821
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0101 0.0243 0.0473
Loa Loa (eye worm) hypothetical protein 0.0138 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0298 0.0987 0.0987
Brugia malayi ORL1-like opioid receptor 0.0073 0.0138 0.0138
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0233 0.0742 0.1369
Loa Loa (eye worm) p25-alpha family protein 0.0749 0.2687 0.2687
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0147 0.0415 0.0415
Brugia malayi Dopamine receptor protein 2 0.0073 0.0138 0.0138
Echinococcus multilocularis glycine receptor subunit beta 0.0298 0.0987 0.1919
Brugia malayi p25-alpha family protein 0.0749 0.2687 0.2687
Echinococcus multilocularis neuropeptides capa receptor 0.0073 0.0138 0.0268
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0298 0.0987 0.0987
Loa Loa (eye worm) hypothetical protein 0.026 0.0843 0.0843
Schistosoma mansoni neuropeptide receptor 0.0073 0.0138 0.0506
Onchocerca volvulus 0.0073 0.0138 0.0514
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0073 0.0138 0.0506
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0298 0.0987 0.0987
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.015 0.0429 0.0792
Schistosoma mansoni sodium/chloride dependent transporter 0.0146 0.0413 0.1515
Onchocerca volvulus 0.0069 0.0123 0.0458
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0147 0.0415 0.1523
Echinococcus granulosus Nuclear hormone receptor HR96 0.0069 0.0123 0.0227
Brugia malayi hypothetical protein 0.0138 0.0381 0.0381
Echinococcus granulosus tm gpcr rhodopsin 0.0073 0.0138 0.0255
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0147 0.0415 0.0415
Onchocerca volvulus 0.0298 0.0987 0.3674
Loa Loa (eye worm) nuclear receptor NHR-67 0.0069 0.0123 0.0123
Loa Loa (eye worm) GABA receptor subunit 0.0161 0.0468 0.0468
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0298 0.0987 0.3622
Loa Loa (eye worm) hypothetical protein 0.0077 0.0154 0.0154
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.0109 0.0202
Brugia malayi hypothetical protein 0.0069 0.0123 0.0123
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0082 0.0171 0.0171
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0073 0.0138 0.0506
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0147 0.0415 0.1545
Echinococcus multilocularis g protein coupled receptor 0.0073 0.0138 0.0268
Onchocerca volvulus 0.0073 0.0138 0.0514
Brugia malayi Nuclear hormone receptor-like 1 0.0077 0.0154 0.0154
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0093 0.0342
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0053 0.0053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0069 0.0123 0.0239
Loa Loa (eye worm) hypothetical protein 0.0298 0.0987 0.0987
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0069 0.0123 0.0123
Echinococcus multilocularis beta LACTamase domain containing family member 0.0082 0.0171 0.0332
Schistosoma mansoni RAR-like nuclear receptor 0.0147 0.0415 0.1523
Brugia malayi beta-lactamase 0.0082 0.0171 0.0171
Brugia malayi beta-lactamase family protein 0.0082 0.0171 0.0171
Brugia malayi G-protein coupled receptor 0.0073 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0101 0.0243 0.0243
Echinococcus multilocularis G protein coupled receptor 139 0.0222 0.0701 0.1363
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0099 0.0236 0.0868
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0109 0.0402
Mycobacterium tuberculosis Probable hydrolase 0.0082 0.0171 0.0659
Loa Loa (eye worm) hypothetical protein 0.0298 0.0987 0.0987
Onchocerca volvulus 0.0082 0.0171 0.0636
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0147 0.0415 0.0415
Echinococcus multilocularis allatostatin A receptor 0.0073 0.0138 0.0268
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0082 0.0171 0.0659
Loa Loa (eye worm) hypothetical protein 0.0161 0.0468 0.0468
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0147 0.0415 0.0766
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0051 0.0053 0.0196
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0069 0.0123 0.0227
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0101 0.0243 0.0473
Echinococcus granulosus alpha 1A adrenergic receptor 0.0073 0.0138 0.0255
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.1353 0.263
Schistosoma mansoni hypothetical protein 0.0053 0.0062 0.0228
Brugia malayi sulfakinin receptor protein 0.0073 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0069 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0147 0.0415 0.0415
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0053 0.0104
Loa Loa (eye worm) hypothetical protein 0.0069 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0325 0.1089 0.1089
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0073 0.0138 0.0268
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0146 0.0413 0.1515
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0152 0.0435 0.0404
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Brugia malayi Nuclear hormone receptor-like 1 0.0077 0.0154 0.0154
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0298 0.0987 0.0987
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0147 0.0415 0.0415
Mycobacterium ulcerans esterase/lipase LipP 0.0082 0.0171 0.1525
Brugia malayi Latrophilin receptor protein 2 0.0098 0.0231 0.0231
Echinococcus granulosus tachykinin peptides receptor 99D 0.0073 0.0138 0.0255
Brugia malayi nuclear receptor NHR-88 0.0147 0.0415 0.0415
Loa Loa (eye worm) hypothetical protein 0.0082 0.0171 0.0171
Brugia malayi neuropeptide F receptor 0.0073 0.0138 0.0138
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0147 0.0415 0.0766
Onchocerca volvulus 0.0073 0.0138 0.0514
Brugia malayi Tachykinin-like peptides receptor 99D 0.0073 0.0138 0.0138
Echinococcus multilocularis dro:myosuppressin receptor 0.0073 0.0138 0.0268
Loa Loa (eye worm) hypothetical protein 0.0077 0.0154 0.0154
Onchocerca volvulus 0.0053 0.0062 0.0231
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0053 0.0104
Echinococcus granulosus neuropeptide s receptor 0.0073 0.0138 0.0255
Onchocerca volvulus Neuropeptide F receptor homolog 0.0073 0.0138 0.0514
Trypanosoma cruzi Emopamil binding protein, putative 0.0133 0.0365 0.0365
Schistosoma mansoni hypothetical protein 0.0211 0.0659 0.2419
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0082 0.0171 0.0171
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0138 0.0255
Brugia malayi hypothetical protein 0.0073 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Brugia malayi nuclear receptor NHR-67 0.0069 0.0123 0.0123
Trypanosoma brucei RNA helicase, putative 0.01 0.0239 0.0208
Echinococcus granulosus neuropeptide receptor A26 0.0073 0.0138 0.0255
Brugia malayi hypothetical protein 0.0138 0.0381 0.0381
Brugia malayi hypothetical protein 0.0073 0.0138 0.0138
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0101 0.0243 0.5
Schistosoma mansoni glutamate receptor AMPA 0.0197 0.0604 0.2216
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0077 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0138 0.0381 0.0381
Brugia malayi excitatory GABA receptor EXP-1A 0.0298 0.0987 0.0987
Echinococcus granulosus glycine receptor subunit alpha 1 0.0298 0.0987 0.1821
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0098 0.0231 0.0426
Echinococcus multilocularis sex peptide receptor 0.0073 0.0138 0.0268
Brugia malayi larval opioid receptor 0.0073 0.0138 0.0138
Schistosoma mansoni hypothetical protein 0.0073 0.0138 0.0506
Schistosoma mansoni amine GPCR 0.0073 0.0138 0.0506
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0073 0.0138 0.0138
Onchocerca volvulus 0.0133 0.0365 0.136
Onchocerca volvulus Putative nachr subunit 0.0298 0.0987 0.3674
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0073 0.0138 0.0138
Echinococcus multilocularis serotonin receptor 0.0073 0.0138 0.0268
Schistosoma mansoni neurotransmitter gated ion channel 0.0138 0.0381 0.1398
Schistosoma mansoni nAChR subunit 0.0298 0.0987 0.3622
Loa Loa (eye worm) hypothetical protein 0.0298 0.0987 0.0987
Brugia malayi beta-lactamase family protein 0.0082 0.0171 0.0171
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0298 0.0987 0.1919
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0138 0.0381 0.0741
Onchocerca volvulus 0.0073 0.0138 0.0514
Onchocerca volvulus 0.0073 0.0138 0.0514
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0233 0.0742 0.1369
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0032 0.0032
Onchocerca volvulus 0.0298 0.0987 0.3674
Brugia malayi Dopamine receptor protein 1 0.0073 0.0138 0.0138
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0073 0.0138 0.0268
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0298 0.0987 0.3622
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0298 0.0987 0.0987
Loa Loa (eye worm) hypothetical protein 0.0146 0.0413 0.0413
Leishmania major hypothetical protein, conserved 0.0082 0.0171 0.0171
Echinococcus granulosus acetylcholinesterase 0.0072 0.0135 0.0249
Brugia malayi photoreceptor-specific nuclear receptor 0.0147 0.0415 0.0415
Onchocerca volvulus 0.0073 0.0138 0.0514
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0079 0.016 0.016
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0298 0.0987 0.0987
Loa Loa (eye worm) ACC-1 protein 0.0298 0.0987 0.0987
Schistosoma mansoni neuropeptide receptor 0.0222 0.0701 0.2572
Echinococcus multilocularis glutamate receptor 2 0.0135 0.0373 0.0725
Loa Loa (eye worm) norepinephrine transporter 0.0146 0.0413 0.0413
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0082 0.0171 0.1525
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.015 0.0429 0.0834
Brugia malayi Carboxylesterase family protein 0.0072 0.0135 0.0135
Echinococcus granulosus glutamate receptor subunit protein glur 0.0098 0.0231 0.0426
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0133 0.0365 0.0365
Schistosoma mansoni hypothetical protein 0.0098 0.0231 0.0848
Schistosoma mansoni nAChR subunit 0.0298 0.0987 0.3622
Schistosoma mansoni hypothetical protein 0.0098 0.0231 0.0848
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0138 0.0506
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0298 0.0987 0.3622
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0321 0.1072 0.1043
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0069 0.0123 0.0123
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0069 0.0844
Schistosoma mansoni zinc finger protein 0.0069 0.0123 0.0451
Schistosoma mansoni amine GPCR 0.0073 0.0138 0.0506
Schistosoma mansoni glutamate receptor kainate 0.0197 0.0604 0.2216
Brugia malayi hypothetical protein 0.0073 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0298 0.0987 0.0987
Echinococcus granulosus tm gpcr rhodopsin 0.0596 0.2109 0.3892
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0298 0.0987 0.1821
Loa Loa (eye worm) hypothetical protein 0.0099 0.0236 0.0236
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0079 0.016 0.0296
Echinococcus granulosus biogenic amine 5HT receptor 0.0073 0.0138 0.0255
Schistosoma mansoni growth hormone secretagogue receptor 0.0073 0.0138 0.0506
Loa Loa (eye worm) hypothetical protein 0.0298 0.0987 0.0987
Mycobacterium tuberculosis Probable lipase LipE 0.0082 0.0171 0.0659
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0298 0.0987 0.1821
Loa Loa (eye worm) hypothetical protein 0.0138 0.0381 0.0381
Echinococcus granulosus carboxylesterase 5A 0.0072 0.0135 0.0249
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0112 0.0328
Echinococcus granulosus serotonin receptor 0.0073 0.0138 0.0255
Echinococcus granulosus nmda type glutamate receptor 0.0289 0.0953 0.1758
Schistosoma mansoni glutamate receptor AMPA 0.0197 0.0604 0.2216
Brugia malayi Steroid receptor seven-up type 2 0.0147 0.0415 0.0415
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.0429 0.1574
Brugia malayi G-protein coupled receptor 0.0073 0.0138 0.0138
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0147 0.0415 0.0807
Onchocerca volvulus 0.0073 0.0138 0.0514
Brugia malayi Glutamate receptor 1 precursor 0.0197 0.0604 0.0604
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.0429 0.1574
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0147 0.0415 0.0766
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.0098 0.0181
Echinococcus multilocularis NMDA receptor 0.0098 0.0231 0.0449
Echinococcus granulosus glutamate NMDA receptor subunit 0.0491 0.1715 0.3165
Loa Loa (eye worm) hypothetical protein 0.0138 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Loa Loa (eye worm) DR-78 0.0069 0.0123 0.0123
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0102 0.0245 0.5
Echinococcus granulosus dnaJ subfamily B 0.0395 0.1353 0.2496
Schistosoma mansoni nAChR subunit 0.0298 0.0987 0.3622
Echinococcus multilocularis glycine receptor subunit beta 0.0298 0.0987 0.1919
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0138 0.0268
Loa Loa (eye worm) hypothetical protein 0.0077 0.0154 0.0154
Onchocerca volvulus 0.0073 0.0138 0.0514
Mycobacterium tuberculosis Probable lipase LipD 0.0082 0.0171 0.0659
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0073 0.0138 0.0255
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0101 0.0243 1
Echinococcus multilocularis neuropeptide receptor A26 0.0073 0.0138 0.0268
Echinococcus multilocularis glutamate receptor 2 0.0233 0.0742 0.1442
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0298 0.0987 0.1919
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0138 0.0381 0.0381
Schistosoma mansoni Lamin B receptor (ERG24) 0.0088 0.0195 0.0717
Brugia malayi ecdysone receptor 0.0069 0.0123 0.0123
Brugia malayi nuclear hormone receptor 0.0069 0.0123 0.0123
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0161 0.0468 0.1718
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0138 0.0255
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0032 0.0032
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.015 0.0429 0.0429
Loa Loa (eye worm) hypothetical protein 0.0082 0.0171 0.0171
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0073 0.0138 0.0506
Brugia malayi hypothetical protein 0.0138 0.0381 0.0381
Loa Loa (eye worm) TYRA-2 protein 0.0073 0.0138 0.0138
Schistosoma mansoni hypothetical protein 0.0532 0.1868 0.6856
Brugia malayi hypothetical protein 0.0073 0.0138 0.0138
Echinococcus granulosus neuropeptides capa receptor 0.0073 0.0138 0.0255
Loa Loa (eye worm) hypothetical protein 0.0161 0.0468 0.0468
Echinococcus granulosus neuropeptide receptor 0.0073 0.0138 0.0255
Onchocerca volvulus 0.0073 0.0138 0.0514
Brugia malayi Serotonin receptor 0.0073 0.0138 0.0138
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0147 0.0415 0.0766
Onchocerca volvulus 0.0325 0.1089 0.4052
Brugia malayi ecdysteroid receptor 0.0147 0.0415 0.0415
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0073 0.0138 0.0268
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.015 0.0429 0.0429
Loa Loa (eye worm) glutamate receptor 2 0.0197 0.0604 0.0604
Brugia malayi hypothetical protein 0.0077 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0099 0.0236 0.0236
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0109 0.0402
Schistosoma mansoni neuropeptide receptor 0.0073 0.0138 0.0506
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0069 0.0123 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0147 0.0415 0.0415
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0138 0.0268
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0138 0.0506
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0138 0.0381 0.0703
Toxoplasma gondii hypothetical protein 0.0052 0.0057 0.0201
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Schistosoma mansoni nuclear hormone receptor 0.0069 0.0123 0.0451
Loa Loa (eye worm) hypothetical protein 0.0309 0.1028 0.1028
Plasmodium vivax SET domain protein, putative 0.0066 0.0109 0.4773
Echinococcus multilocularis neuropeptides capa receptor 0.0073 0.0138 0.0268
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0032 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0147 0.0415 0.0415
Trypanosoma cruzi C-14 sterol reductase, putative 0.0088 0.0195 0.0195
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0298 0.0987 0.1919
Chlamydia trachomatis glutamine binding protein 0.0102 0.0245 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0147 0.0415 0.0415
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0298 0.0987 0.0987
Loa Loa (eye worm) LGC-31 protein 0.0298 0.0987 0.0987
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0112 0.041
Schistosoma mansoni neuropeptide F-like receptor 0.0073 0.0138 0.0506
Loa Loa (eye worm) ACC-1 protein 0.0298 0.0987 0.0987
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0171 0.0171
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0138 0.0255
Schistosoma mansoni thyroid hormone receptor 0.0147 0.0415 0.1523
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0147 0.0415 0.0766
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0298 0.0987 0.1919
Schistosoma mansoni neurotransmitter gated ion channel 0.0161 0.0468 0.1718
Loa Loa (eye worm) hypothetical protein 0.0298 0.0987 0.0987
Loa Loa (eye worm) hypothetical protein 0.0138 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0298 0.0987 0.0987
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0073 0.0138 0.0506
Loa Loa (eye worm) carboxylesterase 0.0072 0.0135 0.0135
Echinococcus multilocularis acetylcholinesterase 0.0072 0.0135 0.0262
Echinococcus granulosus g protein coupled receptor 0.0073 0.0138 0.0255
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0138 0.0255
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0147 0.0415 0.0807
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0233 0.0742 0.1442
Echinococcus multilocularis g protein coupled receptor 0.0073 0.0138 0.0268
Echinococcus granulosus somatostatin receptor 0.0073 0.0138 0.0255
Loa Loa (eye worm) hypothetical protein 0.0066 0.0109 0.0109
Onchocerca volvulus 0.0073 0.0138 0.0514
Brugia malayi hypothetical protein 0.0325 0.1089 0.1089
Onchocerca volvulus Protein ultraspiracle homolog 0.0147 0.0415 0.1545
Brugia malayi Calcitonin receptor-like protein seb-1 0.0309 0.1028 0.1028
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0147 0.0415 0.0766
Brugia malayi hypothetical protein 0.0073 0.0138 0.0138
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0138 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0069 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0069 0.0123 0.0123
Schistosoma mansoni vesicular amine transporter 0.037 0.1257 0.4613
Schistosoma mansoni biogenic amine receptor 0.0073 0.0138 0.0506
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0147 0.0415 0.0415
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0082 0.0171 0.0627
Leishmania major C-8 sterol isomerase-like protein 0.2687 1 1
Loa Loa (eye worm) beta-lactamase 0.0082 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Onchocerca volvulus 0.0138 0.0381 0.1418
Mycobacterium tuberculosis Probable esterase LipL 0.0082 0.0171 0.0659
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0082 0.0171 0.0627
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.0429 0.1574
Brugia malayi Isocitrate dehydrogenase 0.0051 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0161 0.0468 0.0468
Echinococcus granulosus G protein coupled receptor 139 0.0073 0.0138 0.0255
Onchocerca volvulus 0.0298 0.0987 0.3674
Loa Loa (eye worm) hypothetical protein 0.0073 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0298 0.0987 0.0987
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0109 0.0213
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0102 0.0245 0.1078
Brugia malayi Nuclear hormone receptor E75 0.0069 0.0123 0.0123
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0073 0.0138 0.0255
Schistosoma mansoni acetylcholine receptor-related 0.0138 0.0381 0.1398
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0099 0.0236 0.0436
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0073 0.0138 0.0255
Schistosoma mansoni microtubule-associated protein tau 0.0759 0.2725 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0161 0.0468 0.0468
Loa Loa (eye worm) G-protein coupled receptor 0.0073 0.0138 0.0138
Brugia malayi hypothetical protein 0.026 0.0843 0.0843
Loa Loa (eye worm) hypothetical protein 0.0082 0.0171 0.0171
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0138 0.0506
Echinococcus granulosus nmda type glutamate receptor 0.0452 0.1567 0.2892
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0454 0.1573 0.1573
Brugia malayi hypothetical protein 0.0138 0.0381 0.0381
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0298 0.0987 0.1821
Loa Loa (eye worm) hypothetical protein 0.0298 0.0987 0.0987

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) >= 250 uM Cytostatic concentration required to inhibitcell proliferation in human CEM cell line ChEMBL. 16220981
EC50 (functional) = 0.02 uM Effective concentration required to inhibit HIV-1 induced cytopathicity in human CEM cell line ChEMBL. 16220981
EC50 (functional) = 0.03 uM Effective concentration required to inhibit HIV-1 induced cytopathicity in human MT-4 cell line ChEMBL. 16220981
EC50 (functional) = 3.5 uM Effective concentration required to inhibit HIV-1/138K induced cytopathicity in human CEM cell line ChEMBL. 16220981
EC50 (functional) > 50 uM Effective concentration required to inhibit HIV-2 induced cytopathicity in human CEM cell line ChEMBL. 16220981
EC50 (functional) > 250 uM Effective concentration required to inhibit HIV-2 induced cytopathicity in human MT-4 cell line ChEMBL. 16220981
IC50 (binding) = 3.1 uM Inhibitory concentration required to inhibit recombinant HIV-1 reverse transcriptase ChEMBL. 16220981
SI (functional) >= 12500 Ratio of cytostatic concentration to effective concentration in human CEM cell line ChEMBL. 16220981

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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