TDR Targets

Basic information

Technical information

TDR Targets ID: 36191
Name: 1-(dipropylamino)-3-naphthalen-1-yloxypropan- 2-ol
MW: 301.423 | Formula: C19H27NO2
H donors: 1 H acceptors: 1 LogP: 4.35 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCCN(CC(COc1cccc2c1cccc2)O)CCC
InChi: 1S/C19H27NO2/c1-3-12-20(13-4-2)14-17(21)15-22-19-11-7-9-16-8-5-6-10-18(16)19/h5-11,17,21H,3-4,12-15H2,1-2H3
InChiKey: FHKKLVGOJFXBCC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(dipropylamino)-3-(1-naphthyloxy)propan-2-ol
1-(dipropylamino)-3-(1-naphthalenyloxy)-2-propanol
1-(dipropylamino)-3-naphthalen-1-yloxy-propan-2-ol
1-(dipropylamino)-3-(1-naphthoxy)propan-2-ol

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Serotonin 1a (5-HT1a) receptor	Starlite/ChEMBL	References
Rattus norvegicus	Serotonin 1b (5-HT1b) receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_141128	All targets in OG5_141128
Brugia malayi	Serotonin/octopamine receptor family protein 7	Get druggable targets OG5_141128	All targets in OG5_141128
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_141128	All targets in OG5_141128
Schistosoma japonicum	ko:K04165 Oamb gene product from transcript, putative	Get druggable targets OG5_141128	All targets in OG5_141128
Schistosoma japonicum	Octopamine receptor, putative	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma japonicum	ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma japonicum	expressed protein	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma mansoni	biogenic amine (5HT) receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133249	All targets in OG5_133249
Echinococcus granulosus	biogenic amine 5HT receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	Get druggable targets OG5_141128	All targets in OG5_141128
Echinococcus multilocularis	serotonin receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133249	All targets in OG5_133249
Echinococcus multilocularis	serotonin receptor	Get druggable targets OG5_133249	All targets in OG5_133249

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	sulfakinin receptor protein	Serotonin 1b (5-HT1b) receptor	386 aa	344 aa	23.3 %
Echinococcus granulosus	dro:myosuppressin receptor	Serotonin 1b (5-HT1b) receptor	386 aa	349 aa	18.6 %
Schistosoma japonicum	Octopamine receptor 1, putative	Serotonin 1a (5-HT1a) receptor	422 aa	424 aa	24.3 %
Onchocerca volvulus		Serotonin 1a (5-HT1a) receptor	422 aa	407 aa	23.3 %
Loa Loa (eye worm)	TYRA-2 protein	Serotonin 1a (5-HT1a) receptor	422 aa	491 aa	27.3 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Serotonin 1b (5-HT1b) receptor	386 aa	332 aa	21.7 %
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Serotonin 1a (5-HT1a) receptor	422 aa	392 aa	20.7 %
Echinococcus multilocularis	dro:myosuppressin receptor	Serotonin 1b (5-HT1b) receptor	386 aa	349 aa	18.6 %
Echinococcus multilocularis	g protein coupled receptor	Serotonin 1a (5-HT1a) receptor	422 aa	432 aa	23.6 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Serotonin 1a (5-HT1a) receptor	422 aa	410 aa	27.8 %
Echinococcus multilocularis	neuropeptides capa receptor	Serotonin 1a (5-HT1a) receptor	422 aa	430 aa	20.0 %
Echinococcus multilocularis	g protein coupled receptor	Serotonin 1a (5-HT1a) receptor	422 aa	433 aa	22.4 %
Onchocerca volvulus	26S proteasome non-ATPase regulatory subunit 1 homolog	Serotonin 1b (5-HT1b) receptor	386 aa	371 aa	26.1 %
Onchocerca volvulus	Forkhead box protein biniou homolog	Serotonin 1b (5-HT1b) receptor	386 aa	333 aa	21.3 %
Echinococcus multilocularis	serotonin receptor	Serotonin 1b (5-HT1b) receptor	386 aa	393 aa	32.3 %
Onchocerca volvulus	Phospholipase d-related homolog	Serotonin 1b (5-HT1b) receptor	386 aa	350 aa	18.6 %
Onchocerca volvulus		Serotonin 1b (5-HT1b) receptor	386 aa	354 aa	20.1 %
Schistosoma japonicum	ko:K04255 opsin 4 (melanopsin), putative	Serotonin 1b (5-HT1b) receptor	386 aa	359 aa	22.0 %
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Serotonin 1a (5-HT1a) receptor	422 aa	417 aa	21.1 %
Echinococcus granulosus	g protein coupled receptor	Serotonin 1a (5-HT1a) receptor	422 aa	432 aa	24.3 %
Echinococcus granulosus	alpha 1A adrenergic receptor	Serotonin 1a (5-HT1a) receptor	422 aa	452 aa	21.0 %
Onchocerca volvulus		Serotonin 1a (5-HT1a) receptor	422 aa	390 aa	33.6 %
Onchocerca volvulus		Serotonin 1b (5-HT1b) receptor	386 aa	333 aa	21.0 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Serotonin 1a (5-HT1a) receptor	422 aa	448 aa	29.7 %
Schistosoma mansoni	dro/myosuppressin receptor	Serotonin 1b (5-HT1b) receptor	386 aa	334 aa	24.0 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Serotonin 1b (5-HT1b) receptor	386 aa	331 aa	30.8 %
Echinococcus granulosus	thyrotropin releasing hormone receptor	Serotonin 1b (5-HT1b) receptor	386 aa	355 aa	24.2 %
Schistosoma japonicum	ko:K04136 adrenergic receptor, alpha 1b, putative	Serotonin 1a (5-HT1a) receptor	422 aa	444 aa	29.3 %
Schistosoma mansoni	amine GPCR	Serotonin 1a (5-HT1a) receptor	422 aa	440 aa	31.6 %
Onchocerca volvulus		Serotonin 1a (5-HT1a) receptor	422 aa	436 aa	23.9 %
Onchocerca volvulus		Serotonin 1b (5-HT1b) receptor	386 aa	363 aa	34.4 %
Onchocerca volvulus		Serotonin 1a (5-HT1a) receptor	422 aa	426 aa	29.6 %
Schistosoma japonicum	ko:K04207 neuropeptide Y receptor Y5, putative	Serotonin 1a (5-HT1a) receptor	422 aa	339 aa	23.0 %
Echinococcus multilocularis	neuropeptide receptor	Serotonin 1b (5-HT1b) receptor	386 aa	331 aa	21.4 %
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	Serotonin 1a (5-HT1a) receptor	422 aa	350 aa	20.6 %
Brugia malayi	GnHR receptor homolog	Serotonin 1b (5-HT1b) receptor	386 aa	335 aa	21.8 %
Echinococcus granulosus	orexin receptor type 2	Serotonin 1a (5-HT1a) receptor	422 aa	369 aa	22.0 %
Echinococcus multilocularis	thyrotropin releasing hormone receptor	Serotonin 1b (5-HT1b) receptor	386 aa	355 aa	24.2 %
Echinococcus granulosus	neuropeptide receptor	Serotonin 1b (5-HT1b) receptor	386 aa	331 aa	21.8 %
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Serotonin 1b (5-HT1b) receptor	386 aa	310 aa	21.6 %
Onchocerca volvulus	Mitochondrial inner membrane protein homolog	Serotonin 1a (5-HT1a) receptor	422 aa	383 aa	30.5 %
Onchocerca volvulus	Glycoprotein hormone beta 5 homolog	Serotonin 1a (5-HT1a) receptor	422 aa	477 aa	24.3 %
Loa Loa (eye worm)	hypothetical protein	Serotonin 1a (5-HT1a) receptor	422 aa	388 aa	26.5 %
Schistosoma mansoni	biogenic amine (5HT) receptor	Serotonin 1b (5-HT1b) receptor	386 aa	344 aa	33.4 %
Echinococcus multilocularis	orexin receptor type 2	Serotonin 1a (5-HT1a) receptor	422 aa	369 aa	22.2 %
Echinococcus granulosus	g protein coupled receptor	Serotonin 1a (5-HT1a) receptor	422 aa	432 aa	23.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.0035	0.0525	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0026	0.0273	0.0213
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0021	0.0156	0.0076
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0026	0.0273	0.0183
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0092	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0021	0.0156	0.0065
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0026	0.0273	0.0213
Schistosoma mansoni	myosin xvIII	0.0021	0.0156	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0273	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Onchocerca volvulus		0.0021	0.0156	0.0577
Brugia malayi	Cytochrome P450 family protein	0.0023	0.0194	0.0194
Loa Loa (eye worm)	G-protein coupled receptor	0.0021	0.0156	0.0065
Brugia malayi	photoreceptor-specific nuclear receptor	0.0026	0.0273	0.0273
Loa Loa (eye worm)	TK/ROR protein kinase	0.0022	0.0178	0.0087
Echinococcus multilocularis	sex peptide receptor	0.0021	0.0156	0.0076
Loa Loa (eye worm)	neuropeptide F receptor	0.0021	0.0156	0.0065
Schistosoma mansoni	retinoic acid receptor RXR	0.0026	0.0273	0.0183
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0021	0.0156	0.0076
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0238	0.175
Entamoeba histolytica	hypothetical protein	0.0035	0.0525	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0026	0.0273	0.2002
Schistosoma mansoni	cell polarity protein	0.005	0.0956	0.0872
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0525	0.0511
Schistosoma mansoni	neuropeptide f receptor 76f	0.0021	0.0156	0.0065
Brugia malayi	hypothetical protein	0.0021	0.0156	0.0156
Plasmodium falciparum	cysteine repeat modular protein 1	0.0022	0.0178	0.5874
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0026	0.0273	0.0183
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0021	0.0156	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0884	0.0799
Schistosoma mansoni	hypothetical protein	0.0122	0.2919	0.2853
Entamoeba histolytica	hypothetical protein	0.0035	0.0525	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0156	0.0076
Schistosoma mansoni	amine GPCR	0.0021	0.0156	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0168	0.4209	0.4156
Echinococcus multilocularis	family S10 non peptidase ue (S10 family)	0.0044	0.0792	0.0827
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0156	0.0065
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0021	0.0156	0.0076
Brugia malayi	neuropeptide F receptor	0.0021	0.0156	0.0156
Onchocerca volvulus	Bile acid receptor homolog	0.0026	0.0273	0.2002
Schistosoma mansoni	opsin-like receptor	0.0021	0.0156	0.0065
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.002	0.0109	0.0017
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.002	0.0109	0.002
Brugia malayi	nuclear hormone receptor	0.0026	0.0273	0.0273
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.002	0.0109	0.002
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0021	0.0156	0.0065
Trypanosoma brucei	serine peptidase, Clan SC, Family S10	0.0049	0.0927	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0026	0.0273	0.0273
Brugia malayi	laminin-like protein K08C7.3 precursor	0.005	0.0956	0.0956
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.002	0.0109	0.002
Schistosoma mansoni	nuclear hormone receptor	0.0026	0.0273	0.0183
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.002	0.0109	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0168	0.4209	0.4156
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0026	0.0273	0.0273
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.002	0.0109	0.0017
Echinococcus multilocularis	neuropeptides capa receptor	0.0021	0.0156	0.0076
Echinococcus granulosus	tumor protein p63	0.0326	0.8564	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0021	0.0156	0.0076
Schistosoma mansoni	hypothetical protein	0.0035	0.0525	0.0437
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.002	0.0109	0.002
Loa Loa (eye worm)	LGC-31 protein	0.002	0.0109	0.0017
Onchocerca volvulus		0.0021	0.0156	0.0577
Echinococcus granulosus	neuropeptide receptor A26	0.0021	0.0156	0.0076
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0156	0.0076
Brugia malayi	hypothetical protein	0.0021	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Schistosoma mansoni	nAChR subunit	0.002	0.0109	0.0017
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0021	0.0156	0.0065
Brugia malayi	hypothetical protein	0.0021	0.0156	0.0156
Mycobacterium ulcerans	aldehyde dehydrogenase	0.012	0.2868	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0238	0.175
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0026	0.0273	0.0183
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0122	0.2919	0.3337
Echinococcus multilocularis	neuropeptide receptor A26	0.0021	0.0156	0.0076
Schistosoma mansoni	family S10 unassigned peptidase (S10 family)	0.0049	0.0927	0.0843
Brugia malayi	Cation transporter family protein	0.002	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0315	0.0225
Brugia malayi	G protein-coupled receptor F59B2.13	0.0021	0.0156	0.0156
Schistosoma mansoni	family S10 non-peptidase homologue (S10 family)	0.0049	0.0927	0.0843
Schistosoma mansoni	nAChR subunit	0.002	0.0109	0.0017
Schistosoma mansoni	amine GPCR	0.0021	0.0156	0.0065
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0021	0.0156	0.0076
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0021	0.0156	0.0076
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0026	0.0273	0.0183
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0021	0.0156	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0927	0.0843
Echinococcus granulosus	neuropeptide Y receptor	0.0021	0.0156	0.0076
Loa Loa (eye worm)	hypothetical protein	0.002	0.0109	0.0017
Echinococcus granulosus	biogenic amine 5HT receptor	0.0021	0.0156	0.0076
Schistosoma mansoni	hypothetical protein	0.0068	0.1433	0.1354
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.002	0.0109	0.0109
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.002	0.0109	0.002
Loa Loa (eye worm)	melatonin receptor type 1A	0.0021	0.0156	0.0065
Echinococcus multilocularis	tumor protein p63	0.0326	0.8564	1
Echinococcus granulosus	voltage dependent calcium channel subunit	0.0288	0.7512	0.8758
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0026	0.0273	0.0213
Brugia malayi	neuropeptide F receptor	0.0021	0.0156	0.0156
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0026	0.0273	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0315	0.0225
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.002	0.0109	0.0109
Echinococcus granulosus	allatostatin A receptor	0.0021	0.0156	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0026	0.0273	0.0273
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0156	0.0065
Onchocerca volvulus		0.0021	0.0156	0.0577
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.002	0.0109	0.002
Echinococcus granulosus	sex peptide receptor	0.0021	0.0156	0.0076
Loa Loa (eye worm)	hypothetical protein	0.002	0.0109	0.0017
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0021	0.0156	0.0156
Schistosoma mansoni	laminin gamma-3 chain	0.005	0.0956	0.0872
Schistosoma mansoni	aldehyde dehydrogenase	0.012	0.2868	0.2802
Echinococcus multilocularis	neuropeptide receptor	0.0021	0.0156	0.0076
Echinococcus granulosus	glycine receptor subunit beta	0.002	0.0109	0.002
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0156	0.0076
Loa Loa (eye worm)	hypothetical protein	0.002	0.0109	0.0017
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0026	0.0273	0.0273
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0021	0.0156	0.0076
Echinococcus multilocularis	neuropeptide receptor	0.0021	0.0156	0.0076
Schistosoma mansoni	aldehyde dehydrogenase	0.012	0.2868	0.2802
Trypanosoma cruzi	serine peptidase, Clan SC, Family S10, putative	0.0049	0.0927	1
Schistosoma mansoni	thyroid hormone receptor	0.0147	0.3625	0.3566
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.002	0.0109	0.0017
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.002	0.0109	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0156	0.0065
Brugia malayi	G-protein coupled receptor	0.0021	0.0156	0.0156
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0156	0.0065
Echinococcus granulosus	ecdysone induced protein 78C	0.0026	0.0273	0.0213
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0026	0.0273	0.0183
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0147	0.3625	0.417
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.002	0.0109	0.002
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0109	0.0109
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0021	0.0156	0.0076
Echinococcus multilocularis	neurogenic locus notch protein	0.005	0.0956	0.102
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.0131	0.318	0.3645
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0026	0.0273	0.0213
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.002	0.0109	0.0017
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0021	0.0156	0.0076
Schistosoma mansoni	nAChR subunit	0.002	0.0109	0.0017
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0021	0.0156	0.0065
Echinococcus granulosus	neuropeptide receptor	0.0021	0.0156	0.0076
Onchocerca volvulus		0.0021	0.0156	0.0577
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0168	0.4209	0.4156
Brugia malayi	hypothetical protein	0.0021	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0238	0.0148
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0156	0.0076
Loa Loa (eye worm)	hypothetical protein	0.002	0.0109	0.0017
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.0156	0.0076
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0884	0.0799
Loa Loa (eye worm)	hypothetical protein	0.0379	1	1
Brugia malayi	laminin alpha chain	0.005	0.0956	0.0956
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0021	0.0156	0.0156
Echinococcus multilocularis	g-protein coupled receptor	0.0021	0.0156	0.0076
Echinococcus multilocularis	neuropeptide Y receptor	0.0021	0.0156	0.0076
Loa Loa (eye worm)	hypothetical protein	0.002	0.0109	0.0017
Brugia malayi	G protein-coupled receptor	0.0021	0.0156	0.0156
Trypanosoma cruzi	serine carboxypeptidase (CBP1), putative	0.0049	0.0927	1
Brugia malayi	hypothetical protein	0.0021	0.0156	0.0156
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0021	0.0156	0.0156
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.002	0.0109	0.002
Echinococcus granulosus	glycine receptor subunit alpha 1	0.002	0.0109	0.002
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Schistosoma mansoni	chondroitin sulfate proteoglycan-related	0.005	0.0956	0.0872
Schistosoma mansoni	amine GPCR	0.0021	0.0156	0.0065
Echinococcus granulosus	neuropeptides capa receptor	0.0021	0.0156	0.0076
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.012	0.2868	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0026	0.0273	0.0213
Schistosoma mansoni	lamin	0.0027	0.0315	0.0225
Onchocerca volvulus		0.0027	0.0315	0.2517
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0026	0.0273	0.0183
Schistosoma mansoni	hypothetical protein	0.0021	0.0156	0.0065
Brugia malayi	RE15519p	0.0021	0.0156	0.0156
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0156	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0156	0.0076
Brugia malayi	Serotonin receptor	0.0021	0.0156	0.0156
Brugia malayi	AKH receptor	0.0021	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Onchocerca volvulus		0.0021	0.0156	0.0577
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.002	0.0109	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Loa Loa (eye worm)	ACC-1 protein	0.002	0.0109	0.0017
Echinococcus granulosus	nAChR subunit	0.002	0.0109	0.002
Loa Loa (eye worm)	hypothetical protein	0.002	0.0109	0.0017
Schistosoma mansoni	nAChR subunit	0.002	0.0109	0.0017
Schistosoma mansoni	hypothetical protein	0.0021	0.0156	0.0065
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.012	0.2868	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0156	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Treponema pallidum	methyl-accepting chemotaxis protein (mcp2-1)	0.0267	0.6924	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0178	0.1028
Loa Loa (eye worm)	hypothetical protein	0.002	0.0109	0.0017
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.0156	0.0076
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0021	0.0156	0.0065
Onchocerca volvulus		0.0021	0.0156	0.0577
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0026	0.0273	0.0213
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.002	0.0109	0.002
Schistosoma mansoni	neuropeptide F-like receptor	0.0021	0.0156	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Brugia malayi	putative neuropeptide receptor NPR1	0.0021	0.0156	0.0156
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0026	0.0273	0.0273
Brugia malayi	Serotonin receptor	0.0021	0.0156	0.0156
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.012	0.2868	0.3277
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.002	0.0109	0.0017
Echinococcus multilocularis	neuropeptides capa receptor	0.0021	0.0156	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0026	0.0273	0.0183
Echinococcus multilocularis	pikachurin	0.005	0.0956	0.102
Brugia malayi	hypothetical protein	0.0021	0.0156	0.0156
Echinococcus granulosus	hypothetical protein	0.0021	0.0156	0.0076
Leishmania major	hypothetical protein, conserved	0.0022	0.0178	0.0309
Echinococcus multilocularis	glycine receptor subunit beta	0.002	0.0109	0.002
Echinococcus granulosus	family S10 non peptidase ue S10 family	0.0044	0.0792	0.0827
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0379	1	1
Brugia malayi	follicle stimulating hormone receptor	0.0021	0.0156	0.0156
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0021	0.0156	0.0065
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0156	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0273	0.0183
Brugia malayi	Cache domain containing protein	0.0058	0.1166	0.1166
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0026	0.0273	0.0183
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.002	0.0109	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Loa Loa (eye worm)	abnormal epIthelia family member	0.005	0.0956	0.0872
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0026	0.0273	0.0183
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0026	0.0273	0.0213
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0525	0.0437
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0315	0.0315
Schistosoma mansoni	thyroid hormone receptor	0.0147	0.3625	0.3566
Echinococcus multilocularis	serotonin receptor	0.0168	0.4209	0.486
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0301	0.0211
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0109	0.0109
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0021	0.0156	0.0065
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.0156	0.0076
Trypanosoma cruzi	serine carboxypeptidase (CBP1), putative	0.0049	0.0927	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0026	0.0273	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Onchocerca volvulus		0.0048	0.0884	0.9472
Schistosoma mansoni	slit	0.005	0.0956	0.0872
Loa Loa (eye worm)	hypothetical protein	0.002	0.0109	0.0017
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0238	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0026	0.0273	0.0183
Loa Loa (eye worm)	ACC-1 protein	0.002	0.0109	0.0017
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0021	0.0156	0.0156
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0156	0.0076
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0026	0.0273	0.0273
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0156	0.0076
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.002	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0156	0.0065
Echinococcus granulosus	7TM GPCR rhodopsin	0.0021	0.0156	0.0076
Echinococcus multilocularis	fmrfamide receptor	0.0021	0.0156	0.0076
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.002	0.0109	0.002
Brugia malayi	Kringle domain containing protein	0.0022	0.0178	0.0178
Echinococcus multilocularis	FTZ F1 alpha	0.0026	0.0273	0.0213
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0021	0.0156	0.0076
Echinococcus granulosus	g protein coupled receptor	0.0021	0.0156	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0021	0.0156	0.0065
Echinococcus granulosus	dro:myosuppressin receptor	0.0021	0.0156	0.0076
Echinococcus multilocularis	neuropeptide Y receptor	0.0021	0.0156	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Brugia malayi	ORL1-like opioid receptor	0.0021	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.002	0.0109	0.0017
Loa Loa (eye worm)	hypothetical protein	0.005	0.0956	0.0872
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0156	0.0065
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.002	0.0109	0.0109
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0156	0.0076
Echinococcus multilocularis	orexin receptor type 2	0.0021	0.0156	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0156	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0109	0.0109
Brugia malayi	hypothetical protein	0.0035	0.0525	0.0525
Brugia malayi	Dopamine receptor	0.0021	0.0156	0.0156
Echinococcus granulosus	neuropeptide Y receptor	0.0021	0.0156	0.0076
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0021	0.0156	0.0577
Echinococcus granulosus	FTZ F1 alpha	0.0026	0.0273	0.0213
Echinococcus granulosus	intermediate filament protein	0.0027	0.0315	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1166	0.1085
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0273	0.0183
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0026	0.0273	0.0183
Echinococcus granulosus	neuropeptide FF receptor 2	0.0021	0.0156	0.0076
Schistosoma mansoni	serine-rich repeat protein	0.0068	0.1433	0.1354
Brugia malayi	EGF-like domain containing protein	0.005	0.0956	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0109	0.0109
Entamoeba histolytica	hypothetical protein	0.0035	0.0525	1
Toxoplasma gondii	aldehyde dehydrogenase	0.012	0.2868	1
Brugia malayi	ecdysteroid receptor	0.0026	0.0273	0.0273
Echinococcus granulosus	g-protein coupled receptor	0.0021	0.0156	0.0076
Loa Loa (eye worm)	neuropeptide F receptor	0.0021	0.0156	0.0065
Brugia malayi	nuclear receptor NHR-88	0.0026	0.0273	0.0273
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0156	0.0076
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0021	0.0156	0.0065
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0021	0.0156	0.0076
Schistosoma mansoni	coup transcription factor	0.0026	0.0273	0.0183
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0021	0.0156	0.0065
Brugia malayi	intermediate filament protein	0.0027	0.0315	0.0315
Onchocerca volvulus		0.0027	0.0315	0.2517
Echinococcus granulosus	g protein coupled receptor	0.0021	0.0156	0.0076
Brugia malayi	sulfakinin receptor protein	0.0021	0.0156	0.0156
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0021	0.0156	0.0065
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0021	0.0156	0.0156
Brugia malayi	GnHR receptor homolog	0.0021	0.0156	0.0156
Brugia malayi	Dopamine receptor protein 1	0.0021	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Echinococcus multilocularis	neuropeptide s receptor	0.0021	0.0156	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Echinococcus granulosus	orexin receptor type 2	0.0021	0.0156	0.0076
Schistosoma mansoni	hypothetical protein	0.0021	0.0156	0.0065
Schistosoma mansoni	histamine h1 receptor	0.0021	0.0156	0.0065
Leishmania major	hypothetical protein, conserved	0.0024	0.0238	0.0527
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0021	0.0156	0.0076
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0021	0.0156	0.0076
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0026	0.0273	0.0183
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0156	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0178	0.0087
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0026	0.0273	0.0213
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0026	0.0273	0.0273
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.002	0.0109	0.002
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0021	0.0156	0.0076
Mycobacterium ulcerans	aldehyde dehydrogenase	0.012	0.2868	1
Onchocerca volvulus		0.0021	0.0156	0.0577
Loa Loa (eye worm)	hypothetical protein	0.005	0.0956	0.0872
Schistosoma mansoni	amine GPCR	0.0021	0.0156	0.0065
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0156	0.0065
Brugia malayi	Melatonin receptor type 1A	0.0021	0.0156	0.0156
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0021	0.0156	0.0065
Echinococcus multilocularis	G protein coupled receptor 139	0.0021	0.0156	0.0076
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0238	0.0527
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0026	0.0273	0.0273
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0026	0.0273	0.0273
Onchocerca volvulus		0.0021	0.0156	0.0577
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.002	0.0109	0.0017
Loa Loa (eye worm)	G-protein coupled receptor	0.0021	0.0156	0.0065
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0026	0.0273	0.0213
Brugia malayi	Cation transporter family protein	0.002	0.0109	0.0109
Echinococcus granulosus	voltage dependent calcium channel subunit	0.0131	0.318	0.3645
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.0156	0.0076
Onchocerca volvulus		0.0026	0.0273	0.2002
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Echinococcus multilocularis	glycine receptor subunit beta	0.002	0.0109	0.002
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.002	0.0109	0.0017
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0021	0.0156	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0021	0.0156	0.0577
Schistosoma mansoni	opsin-like receptor	0.0021	0.0156	0.0065
Brugia malayi	Dopamine receptor protein 2	0.0021	0.0156	0.0156
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0026	0.0273	0.0213
Schistosoma mansoni	hypothetical protein	0.0021	0.0156	0.0065
Schistosoma mansoni	opsin-like receptor	0.0021	0.0156	0.0065
Echinococcus granulosus	biogenic amine 5HT receptor	0.0168	0.4209	0.486
Echinococcus granulosus	neuropeptide receptor	0.0021	0.0156	0.0076
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.0156	0.0076
Echinococcus granulosus	G protein coupled receptor 139	0.0021	0.0156	0.0076
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0026	0.0273	0.2002
Echinococcus multilocularis	somatostatin receptor	0.0021	0.0156	0.0076
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0021	0.0156	0.0076
Brugia malayi	hypothetical protein	0.0021	0.0156	0.0156
Trypanosoma brucei	serine peptidase, Clan SC, Family S10	0.0049	0.0927	1
Onchocerca volvulus		0.0021	0.0156	0.0577
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0021	0.0156	0.0076
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0109	0.0109
Echinococcus granulosus	pikachurin	0.005	0.0956	0.102
Brugia malayi	steroid hormone receptor	0.0026	0.0273	0.0273
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.0156	0.0076
Echinococcus granulosus	glycine receptor subunit alpha 1	0.002	0.0109	0.002
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0026	0.0273	0.0273
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0156	0.0065
Echinococcus granulosus	slit 2 protein	0.005	0.0956	0.102
Brugia malayi	excitatory GABA receptor EXP-1A	0.002	0.0109	0.0109
Echinococcus multilocularis	nAChR subunit	0.002	0.0109	0.002
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0026	0.0273	0.0183
Brugia malayi	Serine carboxypeptidase F41C3.5 precursor	0.0049	0.0927	0.0927
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.002	0.0109	0.002
Mycobacterium ulcerans	aldehyde dehydrogenase	0.012	0.2868	1
Echinococcus multilocularis	allatostatin A receptor	0.0021	0.0156	0.0076
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0021	0.0156	0.0076
Schistosoma mansoni	nAChR subunit	0.002	0.0109	0.0017
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0026	0.0273	0.0213
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0156	0.0076
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0525	0.0511
Trypanosoma cruzi	serine peptidase, Clan SC, Family S10, putative	0.0049	0.0927	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0026	0.0273	0.0213
Schistosoma mansoni	nAChR subunit	0.002	0.0109	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0273	0.0183
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.002	0.0109	0.002
Echinococcus granulosus	7tm_1 domain containing protein	0.0021	0.0156	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0273	0.0183
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0156	0.0065
Loa Loa (eye worm)	hypothetical protein	0.002	0.0109	0.0017
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0315	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0273	0.0183
Echinococcus granulosus	lysosomal protective protein	0.0049	0.0927	0.0986
Loa Loa (eye worm)	hypothetical protein	0.005	0.0956	0.0872
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0022	0.0178	0.5874
Brugia malayi	G-protein coupled receptor	0.0021	0.0156	0.0156
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0092	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0238	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0156	0.0065
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.0288	0.7512	0.8758
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0156	0.0065
Echinococcus granulosus	somatostatin receptor	0.0021	0.0156	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Echinococcus multilocularis	musashi	0.0027	0.0315	0.0263
Echinococcus granulosus	tissue type plasminogen activator	0.0022	0.0178	0.0101
Onchocerca volvulus		0.0021	0.0156	0.0577
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.002	0.0109	0.002
Onchocerca volvulus		0.0021	0.0156	0.0577
Leishmania major	serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10	0.0049	0.0927	0.3008
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.002	0.0109	0.0109
Echinococcus granulosus	fmrfamide receptor	0.0021	0.0156	0.0076
Loa Loa (eye worm)	hypothetical protein	0.002	0.0109	0.0017
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0021	0.0156	0.0065
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.002	0.0109	0.0109
Schistosoma mansoni	neuropeptide F-like receptor	0.0021	0.0156	0.0065
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.002	0.0109	0.002
Schistosoma mansoni	lamin	0.0027	0.0315	0.0225
Onchocerca volvulus		0.0021	0.0156	0.0577
Echinococcus multilocularis	lysosomal protective protein	0.0049	0.0927	0.0986
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0156	0.0065
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0156	0.0076
Echinococcus multilocularis	serotonin receptor	0.0168	0.4209	0.486
Brugia malayi	Steroid receptor seven-up type 2	0.0026	0.0273	0.0273
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.002	0.0109	0.0017
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.002	0.0109	0.002
Loa Loa (eye worm)	hypothetical protein	0.0379	1	1
Onchocerca volvulus		0.0021	0.0156	0.0577
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.012	0.2868	0.3277
Loa Loa (eye worm)	TYRA-2 protein	0.0021	0.0156	0.0065
Onchocerca volvulus	Uncharacterized serine carboxypeptidase homolog	0.0049	0.0927	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.0063	0.1314	0.1233
Echinococcus multilocularis	slit 2 protein	0.005	0.0956	0.102
Echinococcus multilocularis	fmrfamide receptor	0.0021	0.0156	0.0076
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0021	0.0156	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0156	0.0065
Onchocerca volvulus		0.0021	0.0156	0.0577
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0156	0.0065
Echinococcus multilocularis	lamin	0.0027	0.0315	0.0263
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0021	0.0156	0.0076
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0092	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0021	0.0156	0.0076
Echinococcus granulosus	lamin dm0	0.0027	0.0315	0.0263
Loa Loa (eye worm)	hypothetical protein	0.002	0.0109	0.0017
Loa Loa (eye worm)	hypothetical protein	0.002	0.0109	0.0017
Echinococcus granulosus	glycine receptor subunit beta	0.002	0.0109	0.002
Loa Loa (eye worm)	hypothetical protein	0.002	0.0109	0.0017
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0026	0.0273	0.0183
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0156	0.0076
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.0156	0.0076
Brugia malayi	Cation transporter family protein	0.002	0.0109	0.0109
Echinococcus multilocularis	lamin dm0	0.0027	0.0315	0.0263
Schistosoma mansoni	amine GPCR	0.0021	0.0156	0.0065
Echinococcus granulosus	neurogenic locus notch protein	0.005	0.0956	0.102
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Schistosoma mansoni	RAR-like nuclear receptor	0.0026	0.0273	0.0183
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0156	0.0065
Onchocerca volvulus		0.0022	0.0178	0.0841
Schistosoma mansoni	nAChR subunit	0.002	0.0109	0.0017
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0156	0.0065
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.002	0.0109	0.002
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0021	0.0156	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0273	0.0183
Echinococcus granulosus	glycine receptor subunit alpha 1	0.002	0.0109	0.002
Onchocerca volvulus		0.0021	0.0156	0.0577
Echinococcus multilocularis	dro:myosuppressin receptor	0.0021	0.0156	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0273	0.0183
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.002	0.0109	0.002
Echinococcus multilocularis	ecdysone induced protein 78C	0.0026	0.0273	0.0213
Onchocerca volvulus		0.0021	0.0156	0.0577
Echinococcus granulosus	serotonin receptor	0.0021	0.0156	0.0076
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0092	0.5
Loa Loa (eye worm)	steroid hormone receptor	0.0026	0.0273	0.0183
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0026	0.0273	0.0213
Schistosoma mansoni	growth hormone secretagogue receptor	0.0021	0.0156	0.0065
Toxoplasma gondii	kringle domain-containing protein	0.0022	0.0178	0.0309
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0026	0.0273	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Brugia malayi	Thrombospondin N-terminal -like domain containing protein	0.005	0.0956	0.0956
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.0156	0.0076
Brugia malayi	hypothetical protein	0.0021	0.0156	0.0156
Brugia malayi	larval opioid receptor	0.0021	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.002	0.0109	0.0017
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.0126	0.3033	0.2968
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.002	0.0109	0.0017
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0021	0.0156	0.0065
Echinococcus multilocularis	tissue type plasminogen activator	0.0022	0.0178	0.0101
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.0194	0.0103
Brugia malayi	hypothetical protein	0.0021	0.0156	0.0156
Brugia malayi	hypothetical protein	0.0021	0.0156	0.0156
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0315	0.0225
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0238	1
Onchocerca volvulus		0.0021	0.0156	0.0577
Loa Loa (eye worm)	hypothetical protein	0.002	0.0109	0.0017
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0156	0.0076
Schistosoma mansoni	hypothetical protein	0.0022	0.0178	0.0087
Echinococcus granulosus	neuropeptide s receptor	0.0021	0.0156	0.0076
Brugia malayi	putative neuropeptide receptor	0.0021	0.0156	0.0156
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0238	0.175
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0122	0.2919	0.3337
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0109	0.0109
Echinococcus granulosus	lamin	0.0027	0.0315	0.0263
Schistosoma mansoni	adenoreceptor	0.0021	0.0156	0.0065
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.0156	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0021	0.0156	0.0076
Brugia malayi	Nuclear hormone receptor-like 1	0.0026	0.0273	0.0273
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0109	0.0109
Trypanosoma brucei	serine peptidase, Clan SC, Family S10	0.0049	0.0927	1
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.002	0.0109	0.0109
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.002	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0065
Loa Loa (eye worm)	hypothetical protein	0.002	0.0109	0.0017
Echinococcus granulosus	g protein coupled receptor	0.0021	0.0156	0.0076
Brugia malayi	hypothetical protein	0.0024	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.002	0.0109	0.0017

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= -6.35	Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabelled [3H]-8-OH-DPAT ligand displacement	ChEMBL.	8568799
Ki (binding)	= 1325 nM	Inhibitory activity of the compound against 5-hyrdroxytryptamine 1A receptor of rat hippocampal tissue using [3H]-OH-DPAT as radioligand.	ChEMBL.	2539480
Ki (binding)	= 1325 nM	Inhibitory activity of the compound against 5-hyrdroxytryptamine 1A receptor of rat hippocampal tissue using [3H]-OH-DPAT as radioligand.	ChEMBL.	2539480
Ki (binding)	= 8000 nM	Inhibitory activity of the compound against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]-5-HT as the radioligand.	ChEMBL.	2539480
Ki (binding)	= 8000 nM	Inhibitory activity of the compound against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]-5-HT as the radioligand.	ChEMBL.	2539480
Log Ki (binding)	= 6.35	Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabelled [3H]-8-OH-DPAT ligand displacement	ChEMBL.	8568799

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL416564
PubChem: 2914436

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 36191