Detailed information for compound 404814

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 2061.17 | Formula: C103H117N23O24
  • H donors: 26 H acceptors: 25 LogP: -1.26 Rotable bonds: 68
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)Cc1ccc(cc1)O)Cc1ccc(cc1)O)CC(=O)N)Cc1ccccc1)Cc1ccccc1)Cc1c[nH]c2c1cccc2)CC(=O)O)C)[C@H](O)C)Cc1nc[nH]c1)Cc1c[nH]c2c1cccc2)CC(=O)N
  • InChi: 1S/C103H117N23O24/c1-54(113-101(147)89(55(2)127)125-87(133)52-111-90(136)78(43-63-51-107-53-112-63)121-96(142)77(41-61-49-109-70-24-13-10-21-67(61)70)119-97(143)79(44-84(105)130)114-86(132)47-104)102(148)126-35-15-26-83(126)100(146)123-81(46-88(134)135)99(145)120-76(40-60-48-108-69-23-12-9-20-66(60)69)95(141)117-72(36-56-16-5-3-6-17-56)91(137)115-73(37-57-18-7-4-8-19-57)93(139)122-80(45-85(106)131)98(144)118-74(38-58-27-31-64(128)32-28-58)92(138)116-75(39-59-29-33-65(129)34-30-59)94(140)124-82(103(149)150)42-62-50-110-71-25-14-11-22-68(62)71/h3-14,16-25,27-34,48-51,53-55,72-83,89,108-110,127-129H,15,26,35-47,52,104H2,1-2H3,(H2,105,130)(H2,106,131)(H,107,112)(H,111,136)(H,113,147)(H,114,132)(H,115,137)(H,116,138)(H,117,141)(H,118,144)(H,119,143)(H,120,145)(H,121,142)(H,122,139)(H,123,146)(H,124,140)(H,125,133)(H,134,135)(H,149,150)/t54-,55+,72-,73-,74-,75-,76-,77-,78-,79-,80-,81+,82-,83+,89-/m0/s1
  • InChiKey: ZUENRBCVCNXGQC-RSJDORCSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens endothelin receptor type B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei importin beta-1 subunit, putative 0.0065 0.0048 0.0172
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0006 0.0019
Trichomonas vaginalis ran, putative 0.0048 0.0033 0.3726
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0004 0.0055
Schistosoma mansoni ets 0.0024 0.0011 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0003 0.0249
Schistosoma mansoni coup transcription factor 0.0012 0 0.0005
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0001 0.0001
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0009 0.0959
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0 0.0001
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0447 0.0386 0.4778
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0447 0.0386 0.4778
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0447 0.0386 0.4778
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0019 0.0007 0.0082
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0113 0.009 0.1484
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0024
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0163 0.0135 0.0491
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0006 0.0077
Brugia malayi hypothetical protein 0.0447 0.0386 0.0531
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0006 0.0012
Schistosoma mansoni alpha-1 adrenergic receptor 0.0447 0.0386 0.4778
Schistosoma mansoni hypothetical protein 0.0924 0.0808 1
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Onchocerca volvulus 0.0447 0.0386 0.0386
Echinococcus multilocularis ETS transcription factor Elf 2 0.0024 0.0011 0.0139
Echinococcus granulosus Chromobox protein 3 0.0013 0.0001 0.0018
Brugia malayi Tachykinin-like peptides receptor 99D 0.0447 0.0386 0.0531
Echinococcus granulosus translational activator gcn1 0.0012 0.0001 0.0014
Brugia malayi hypothetical protein 0.0447 0.0386 0.0531
Brugia malayi AKH receptor 0.0447 0.0386 0.0531
Loa Loa (eye worm) hypothetical protein 0.0051 0.0036 0.0588
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Echinococcus granulosus orexin receptor type 2 0.0447 0.0386 0.4778
Echinococcus granulosus rhodopsin orphan GPCR 0.0447 0.0386 0.4778
Echinococcus multilocularis neuropeptide receptor 0.0447 0.0386 0.4778
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0014 0.1581
Onchocerca volvulus 0.0447 0.0386 0.0386
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0447 0.0386 0.4778
Brugia malayi Serotonin receptor 0.0447 0.0386 0.0531
Echinococcus multilocularis geminin 0.0194 0.0162 0.1999
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0185
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0033 0.0111
Giardia lamblia Telomerase catalytic subunit 0.3089 0.2724 1
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0037 0.43
Schistosoma mansoni hypothetical protein 0.0695 0.0606 0.7496
Schistosoma mansoni elf1 0.0024 0.0011 0.0139
Loa Loa (eye worm) helicase 0.0013 0.0001 0.0024
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0447 0.0386 0.4778
Echinococcus granulosus cpg binding protein 0.0071 0.0053 0.0653
Onchocerca volvulus 0.0447 0.0386 0.0386
Schistosoma mansoni nuclear hormone receptor 0.0012 0 0.0005
Schistosoma mansoni hypothetical protein 0.0024 0.0011 0.0139
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0001 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0 0.0001
Loa Loa (eye worm) neuropeptide F receptor 0.0447 0.0386 0.6374
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0009 0.003
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0 0.0005
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0 0.0005
Echinococcus multilocularis somatostatin receptor 0.0447 0.0386 0.4778
Trichomonas vaginalis DNA helicase recq1, putative 0.0027 0.0014 0.1515
Echinococcus multilocularis dnaJ subfamily B 0.0924 0.0808 1
Echinococcus granulosus ETS transcription factor Elf 2 0.0024 0.0011 0.0139
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0024 0.0011 0.0185
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0074 0.0055 0.0199
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.0108 0.1786
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0447 0.0386 0.4778
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0447 0.0386 0.6374
Brugia malayi hypothetical protein 0.0341 0.0292 0.0402
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0 0.0005
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0001 0.0018
Brugia malayi sulfakinin receptor protein 0.0447 0.0386 0.0531
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Echinococcus multilocularis sex peptide receptor 0.0447 0.0386 0.4778
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0008 0.0127
Schistosoma mansoni ets-related 0.0024 0.0011 0.0139
Brugia malayi DNA-binding protein D-ETS-3 0.0024 0.0011 0.0015
Brugia malayi Protein cec-1. 0.0013 0.0001 0.0002
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0009 0.0111
Echinococcus multilocularis rhodopsin orphan GPCR 0.0447 0.0386 0.4778
Onchocerca volvulus 0.0013 0.0001 0.0001
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0009 0.0959
Echinococcus multilocularis dro:myosuppressin receptor 0.0447 0.0386 0.4778
Echinococcus multilocularis ewsr:fli fusion protein type 0.0024 0.0011 0.0139
Brugia malayi GnHR receptor homolog 0.0447 0.0386 0.0531
Echinococcus granulosus neuropeptide receptor 0.0447 0.0386 0.4778
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0009 0.0214
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0113 0.009 0.0124
Brugia malayi Bromodomain containing protein 0.0043 0.0028 0.0039
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0048 0.0033 0.0539
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0048 0.0033 0.012
Schistosoma mansoni hypothetical protein 0.0447 0.0386 0.4778
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0006 0.0013
Onchocerca volvulus 0.0447 0.0386 0.0386
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0009 0.003
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0009 0.0965
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.0086 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0447 0.0386 0.4778
Echinococcus granulosus g protein coupled receptor 0.0447 0.0386 0.4778
Echinococcus granulosus sex peptide receptor 0.0447 0.0386 0.4778
Plasmodium vivax heterochromatin protein 1, putative 0.0013 0.0001 0.0001
Onchocerca volvulus 0.0014 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0153
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0006 0.0023
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0023 0.0011 0.0035
Echinococcus granulosus rhodopsin orphan GPCR 0.0447 0.0386 0.4778
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0447 0.0386 0.4778
Echinococcus multilocularis Chromo domain 0.0013 0.0001 0.0018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0006 0.0013
Mycobacterium tuberculosis Probable oxidoreductase 0.0134 0.0109 0.7075
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Echinococcus multilocularis protection of telomeres protein 1 0.0594 0.0516 0.6387
Loa Loa (eye worm) melatonin receptor type 1A 0.0447 0.0386 0.6374
Brugia malayi Thioredoxin reductase 0.0053 0.0037 0.0051
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0024
Echinococcus granulosus serotonin receptor 0.0447 0.0386 0.4778
Brugia malayi putative neuropeptide receptor NPR1 0.0447 0.0386 0.0531
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0023 0.0011 0.0039
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0009 0.6867
Onchocerca volvulus 0.0013 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Onchocerca volvulus 0.0447 0.0386 0.0386
Echinococcus multilocularis g protein coupled receptor 0.0447 0.0386 0.4778
Onchocerca volvulus 0.0447 0.0386 0.0386
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0006 0.0019
Echinococcus granulosus 7tm_1 domain containing protein 0.0447 0.0386 0.4778
Trypanosoma cruzi ISWI complex protein 0.0017 0.0005 0.0009
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0003 0.0006
Schistosoma mansoni neuropeptide receptor 0.0447 0.0386 0.4778
Echinococcus multilocularis g protein coupled receptor 0.0447 0.0386 0.4778
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0059 0.6849
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0447 0.0386 0.0531
Mycobacterium ulcerans hypothetical protein 0.0182 0.0151 1
Loa Loa (eye worm) TYRA-2 protein 0.0447 0.0386 0.6374
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0 0.0005
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0009 0.0199
Loa Loa (eye worm) glutathione reductase 0.0053 0.0037 0.061
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0024
Echinococcus granulosus expressed protein 0.0075 0.0057 0.0705
Onchocerca volvulus 0.0447 0.0386 0.0386
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0029 0.0028
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0134 0.0109 0.7075
Echinococcus granulosus neuropeptides capa receptor 0.0447 0.0386 0.4778
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0447 0.0386 0.4778
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0 0.0005
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0006 0.0019
Loa Loa (eye worm) D-ets-2 protein 0.0024 0.0011 0.0185
Brugia malayi neuropeptide F receptor 0.0447 0.0386 0.0531
Schistosoma mansoni importin beta-1 0.0065 0.0048 0.0592
Onchocerca volvulus 0.0447 0.0386 0.0386
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0003 0.0249
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Loa Loa (eye worm) G-protein coupled receptor 0.0447 0.0386 0.6374
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.0014 0.1515
Echinococcus granulosus geminin 0.0194 0.0162 0.1999
Echinococcus granulosus ETS transcription factor Elf 2 0.0024 0.0011 0.0139
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0447 0.0386 0.4778
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0006 0.0077
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.001 0.0013
Echinococcus multilocularis zinc finger protein 0.0026 0.0013 0.0159
Loa Loa (eye worm) kap beta 3 protein 0.0012 0.0001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Loa Loa (eye worm) hypothetical protein 0.0043 0.0028 0.0464
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0 0.0005
Schistosoma mansoni hypothetical protein 0.0077 0.0058 0.0722
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0016 0.0195
Trypanosoma cruzi polo-like protein kinase, putative 0.0108 0.0086 0.0304
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0003 0.0008
Echinococcus multilocularis neuropeptide receptor A26 0.0447 0.0386 0.4778
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0029 0.3273
Toxoplasma gondii exonuclease III APE 0.0021 0.0009 0.0034
Schistosoma mansoni neuropeptide F-like receptor 0.0447 0.0386 0.4778
Brugia malayi Valyl-tRNA synthetase 0.0013 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Trypanosoma brucei trypanothione reductase 0.0053 0.0037 0.0132
Trypanosoma brucei unspecified product 0.0022 0.0009 0.003
Onchocerca volvulus 0.0341 0.0292 0.0292
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0345 0.0296 0.1081
Echinococcus granulosus g protein coupled receptor 0.0447 0.0386 0.4778
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0013 0.0001 0.0005
Echinococcus granulosus importin subunit beta 1 0.0065 0.0048 0.0592
Onchocerca volvulus 0.0034 0.002 0.002
Echinococcus granulosus importin 5 0.0012 0.0001 0.0014
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0048 0.0033 0.012
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0014 0.1581
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0 0.0005
Loa Loa (eye worm) importin-beta domain-containing protein 0.0012 0.0001 0.0018
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0009 0.0115
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0009 0.0024
Brugia malayi follicle stimulating hormone receptor 0.0447 0.0386 0.0531
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0008 0.0103
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0 0.0005
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0009 0.021
Trypanosoma brucei importin beta-1 subunit, putative 0.0065 0.0048 0.0172
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.0007
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0 0.0005
Loa Loa (eye worm) steroid hormone receptor 0.0012 0 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0 0.0001
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0022 0.0269
Echinococcus multilocularis rhodopsin orphan GPCR 0.0447 0.0386 0.4778
Brugia malayi isocitrate dehydrogenase 0.0018 0.0006 0.0009
Mycobacterium tuberculosis Probable reductase 0.012 0.0097 0.6254
Onchocerca volvulus Neuropeptide F receptor homolog 0.0447 0.0386 0.0386
Brugia malayi hypothetical protein 0.0447 0.0386 0.0531
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0024 0.0011 0.0139
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0011 0.0175
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0036 0.0451
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0447 0.0386 0.4778
Echinococcus multilocularis importin subunit beta 1 0.0065 0.0048 0.0592
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0447 0.0386 0.4778
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0008 0.0868
Echinococcus granulosus GPCR family 2 0.0036 0.0022 0.0269
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0037 0.061
Schistosoma mansoni chromobox protein 0.0078 0.0059 0.0731
Echinococcus granulosus snurportin 1 0.0695 0.0606 0.7496
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Brugia malayi larval opioid receptor 0.0447 0.0386 0.0531
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0013 0.0001 0.0018
Schistosoma mansoni chromobox protein 0.0013 0.0001 0.0018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0036 0.0451
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0016 0.0195
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0036 0.0451
Brugia malayi CXXC zinc finger family protein 0.0065 0.0048 0.0066
Leishmania major DNA polymerase eta, putative 0.0022 0.0009 0.003
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0013 0.0001 0.0001
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0006 0.0013
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0001 0.0043
Echinococcus multilocularis GPCR, family 2 0.0036 0.0022 0.0269
Echinococcus multilocularis rhodopsin orphan GPCR 0.0447 0.0386 0.4778
Loa Loa (eye worm) hypothetical protein 0.0341 0.0292 0.4827
Echinococcus granulosus Chromo domain 0.0013 0.0001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0024
Schistosoma mansoni myosin xvIII 0.0447 0.0386 0.4778
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0447 0.0386 0.4778
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0 0.0001
Giardia lamblia DINP protein human, muc B family 0.0022 0.0009 0.0034
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0013 0.0001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Leishmania major importin beta-1 subunit, putative 0.0053 0.0037 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0001 0.0043
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0006 0.0019
Trypanosoma brucei unspecified product 0.0015 0.0003 0.0008
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0052 0.0649
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0009 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0447 0.0386 0.4778
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0057 0.6604
Loa Loa (eye worm) hypothetical protein 0.0065 0.0048 0.079
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0163 0.0135 0.0491
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0037 0.2123
Echinococcus granulosus chromobox protein 1 0.0078 0.0059 0.0731
Echinococcus granulosus neuropeptide Y receptor 0.0447 0.0386 0.4778
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0006 0.0019
Schistosoma mansoni neuropeptide receptor 0.0447 0.0386 0.4778
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0048 0.0033 0.0116
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0 0.0001
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0074 0.0055 0.0193
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0037 0.43
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0003 0.0249
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0447 0.0386 0.4778
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0009 0.0013
Echinococcus granulosus neuropeptide s receptor 0.0447 0.0386 0.4778
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0037 0.0125
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Toxoplasma gondii RNA-directed DNA polymerase 0.3089 0.2724 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0006 0.0079
Loa Loa (eye worm) hypothetical protein 0.0077 0.0058 0.0963
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0024
Loa Loa (eye worm) ets-domain-containing protein 0.0024 0.0011 0.0185
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0001 0.0043
Brugia malayi CHD4 protein 0.0019 0.0007 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.0086 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0 0.0005
Schistosoma mansoni cpg binding protein 0.0065 0.0048 0.0589
Loa Loa (eye worm) hypothetical protein 0.0117 0.0094 0.1552
Echinococcus granulosus ETS domain containing protein Elk 1 0.0024 0.0011 0.0139
Brugia malayi putative neuropeptide receptor 0.0447 0.0386 0.0531
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0001 0.0043
Echinococcus granulosus protein C ets 2 0.0024 0.0011 0.0139
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0 0.0001
Loa Loa (eye worm) RecQ helicase 0.0027 0.0014 0.023
Echinococcus granulosus ETS transcription factor Elf 1 0.0024 0.0011 0.0139
Onchocerca volvulus 0.0447 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0137
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0009 0.0199
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0 0.0005
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0138 0.0112 0.1386
Schistosoma mansoni hypothetical protein 0.0036 0.0022 0.0269
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0345 0.0296 0.1075
Onchocerca volvulus 0.0447 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Trypanosoma cruzi importin beta-1 subunit, putative 0.0053 0.0037 0.0125
Echinococcus multilocularis serotonin receptor 0.0447 0.0386 0.4778
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0037 0.0132
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0006 0.5
Entamoeba histolytica hypothetical protein 0.0013 0.0001 0.0043
Schistosoma mansoni neuropeptide F-like receptor 0.0447 0.0386 0.4778
Loa Loa (eye worm) hypothetical protein 0.0135 0.011 0.181
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0052 0.0649
Loa Loa (eye worm) hypothetical protein 0.0113 0.009 0.1484
Echinococcus multilocularis fmrfamide receptor 0.0447 0.0386 0.4778
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0447 0.0386 0.4778
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0006 0.0023
Plasmodium vivax importin-beta 2, putative 0.0065 0.0048 0.0172
Schistosoma mansoni zinc finger protein 0.0017 0.0005 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0 0.0007
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0447 0.0386 0.6374
Trichomonas vaginalis Heterochromatin protein, putative 0.0013 0.0001 0.0043
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0447 0.0386 0.6374
Echinococcus multilocularis importin 5 0.0012 0.0001 0.0014
Brugia malayi nuclear receptor NHR-88 0.0012 0 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0 0.0007
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Brugia malayi G protein-coupled receptor 0.0447 0.0386 0.0531
Onchocerca volvulus 0.0065 0.0048 0.0047
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0053 0.0037 0.4236
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0006 0.0077
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Onchocerca volvulus 0.0447 0.0386 0.0386
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0026 0.0318
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0003 0.0008
Schistosoma mansoni biogenic amine (5HT) receptor 0.0447 0.0386 0.4778
Echinococcus multilocularis rhodopsin orphan GPCR 0.0447 0.0386 0.4778
Echinococcus multilocularis GA binding protein alpha chain 0.0164 0.0135 0.1671
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0447 0.0386 0.0531
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0001 0.0043
Schistosoma mansoni thyroid hormone receptor 0.0012 0 0.0005
Toxoplasma gondii HEAT repeat-containing protein 0.0012 0.0001 0.0004
Trichomonas vaginalis importin beta-1, putative 0.0053 0.0037 0.4236
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0007 0.0087
Echinococcus granulosus GTP binding nuclear protein Ran 0.0048 0.0033 0.0404
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0036 0.0451
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Entamoeba histolytica hypothetical protein 0.0013 0.0001 0.0043
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0006 0.0019
Brugia malayi hypothetical protein 0.0447 0.0386 0.0531
Brugia malayi SET domain containing protein 0.0014 0.0003 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0 0.0001
Brugia malayi Bromodomain containing protein 0.0087 0.0068 0.0093
Schistosoma mansoni cpg binding protein 0.0071 0.0053 0.0653
Echinococcus granulosus tachykinin peptides receptor 99D 0.0447 0.0386 0.4778
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0014 0.1581
Trichomonas vaginalis rotamase, putative 0.0075 0.0057 0.6604
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0029 0.3273
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0008 0.0103
Loa Loa (eye worm) hypothetical protein 0.0036 0.0022 0.0359
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0013 0.0001 0.0002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0008 0.0868
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0006 0.0077
Onchocerca volvulus 0.0447 0.0386 0.0386
Schistosoma mansoni biogenic amine (5HT) receptor 0.0447 0.0386 0.4778
Loa Loa (eye worm) CHromoDomain protein family member 0.0019 0.0007 0.011
Brugia malayi nuclear hormone receptor 0.0012 0 0.0001
Echinococcus granulosus 7TM GPCR rhodopsin 0.0447 0.0386 0.4778
Onchocerca volvulus 0.0447 0.0386 0.0386
Echinococcus granulosus biogenic amine 5HT receptor 0.0447 0.0386 0.4778
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0006 0.0013
Schistosoma mansoni hypothetical protein 0.0447 0.0386 0.4778
Schistosoma mansoni biogenic amine receptor 0.0447 0.0386 0.4778
Echinococcus multilocularis neuropeptides capa receptor 0.0447 0.0386 0.4778
Loa Loa (eye worm) fli-1 protein 0.0497 0.043 0.7096
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.012 0.0097 0.6254
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0048 0.0033 0.012
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0447 0.0386 0.0531
Plasmodium vivax glutathione reductase, putative 0.0053 0.0037 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0 0.0001
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.012 0.0097 0.6254
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0006 0.0009
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0004 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0 0.0001
Leishmania major telomerase reverse transcriptase, putative 0.3089 0.2724 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0009 0.0115
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0023 0.0011 0.0028
Brugia malayi Dopamine receptor protein 1 0.0447 0.0386 0.0531
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0048 0.0033 0.0116
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0006 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0447 0.0386 0.4778
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0 0.0005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0001 0.0043
Echinococcus multilocularis snurportin 1 0.0695 0.0606 0.7496
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Echinococcus granulosus alpha 1A adrenergic receptor 0.0447 0.0386 0.4778
Trichomonas vaginalis hypothetical protein 0.0013 0.0001 0.0043
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0036 0.0602
Schistosoma mansoni opsin-like receptor 0.0447 0.0386 0.4778
Echinococcus multilocularis neuropeptide FF receptor 2 0.0447 0.0386 0.4778
Brugia malayi Ets-domain containing protein 0.0024 0.0011 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0009 0.003
Brugia malayi Serotonin receptor 0.0447 0.0386 0.0531
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0447 0.0386 0.4778
Schistosoma mansoni hypothetical protein 0.0036 0.0022 0.0269
Echinococcus granulosus chromobox protein 2 0.0013 0.0001 0.0018
Toxoplasma gondii histone lysine methyltransferase SET1 0.0126 0.0101 0.0372
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0008 0.0103
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0033 0.0118
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0001 0.0002
Brugia malayi hypothetical protein 0.0447 0.0386 0.0531
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0001 0.0043
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0447 0.0386 0.4778
Schistosoma mansoni amine GPCR 0.0447 0.0386 0.4778
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0006 0.0023
Loa Loa (eye worm) hypothetical protein 0.0117 0.0094 0.1552
Brugia malayi kap beta 3 protein 0.0012 0.0001 0.0002
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0006 0.0012
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.012 0.0097 0.6254
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0014 0.1581
Brugia malayi hypothetical protein 0.0447 0.0386 0.0531
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0032 0.0031
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0447 0.0386 0.4778
Schistosoma mansoni neuropeptide receptor 0.0447 0.0386 0.4778
Leishmania major mitochondrial DNA polymerase beta 0.0345 0.0296 0.1081
Trichomonas vaginalis rotamase, putative 0.0074 0.0055 0.6418
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0185
Echinococcus granulosus GA binding protein alpha chain 0.0164 0.0135 0.1671
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0033 0.0111
Echinococcus multilocularis translational activator gcn1 0.0012 0.0001 0.0014
Brugia malayi G-protein coupled receptor 0.0447 0.0386 0.0531
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0447 0.0386 0.4778
Toxoplasma gondii peptidylprolyl isomerase 0.0074 0.0055 0.0203
Echinococcus multilocularis rhodopsin orphan GPCR 0.0447 0.0386 0.4778
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0 0.0001
Echinococcus granulosus hypothetical protein 0.0447 0.0386 0.4778
Brugia malayi Fli-1 protein 0.0497 0.043 0.0591
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0023 0.0011 0.0028
Schistosoma mansoni hypothetical protein 0.0194 0.0162 0.1999
Brugia malayi chromobox protein homolog 3 0.0044 0.0029 0.004
Echinococcus granulosus neuropeptide receptor 0.0447 0.0386 0.4778
Brugia malayi hypothetical protein 0.0447 0.0386 0.0531
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0001 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0009 0.003
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0108 0.0086 0.1061
Echinococcus granulosus rhodopsin orphan GPCR 0.0447 0.0386 0.4778
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0 0.0007
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0022 0.0269
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0024
Loa Loa (eye worm) neuropeptide F receptor 0.0447 0.0386 0.6374
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0002 0.0003
Echinococcus multilocularis ETS transcription factor Elf 1 0.0024 0.0011 0.0139
Echinococcus granulosus biogenic amine 5HT receptor 0.0447 0.0386 0.4778
Schistosoma mansoni opsin-like receptor 0.0447 0.0386 0.4778
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0009 0.003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0014 0.1581
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0004 0.0055
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0006 0.0019
Loa Loa (eye worm) hypothetical protein 0.0034 0.002 0.0338
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0447 0.0386 0.4778
Brugia malayi RNA, U transporter 1 0.0185 0.0154 0.0212
Echinococcus multilocularis neuropeptides capa receptor 0.0447 0.0386 0.4778
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.0086 1
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0009 0.0959
Echinococcus multilocularis rhodopsin orphan GPCR 0.0447 0.0386 0.4778
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0003 0.0249
Echinococcus granulosus tm gpcr rhodopsin 0.0447 0.0386 0.4778
Echinococcus multilocularis serotonin receptor 0.0447 0.0386 0.4778
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0108 0.0086 0.0311
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0447 0.0386 0.4778
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0009 0.003
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0013 0.0001 0.0005
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0006 0.0077
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0037 0.0457
Schistosoma mansoni hypothetical protein 0.0024 0.0011 0.0139
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0001 0.0043
Plasmodium vivax telomerase reverse transcriptase, putative 0.3089 0.2724 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0447 0.0386 0.4778
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0009 0.003
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0134 0.0109 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0108 0.0086 0.1061
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0 0.0007
Plasmodium falciparum telomerase reverse transcriptase 0.3089 0.2724 1
Brugia malayi ORL1-like opioid receptor 0.0447 0.0386 0.0531
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0009 0.003
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0108 0.0086 0.1415
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0006 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0447 0.0386 0.4778
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0 0.0001
Brugia malayi Ets-domain containing protein 0.0164 0.0135 0.0186
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0447 0.0386 0.0531
Schistosoma mansoni cpg binding protein 0.0071 0.0053 0.0653
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0447 0.0386 0.4778
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0006 0.0013
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0009 0.0013
Echinococcus multilocularis chromobox protein 1 0.0078 0.0059 0.0731
Mycobacterium tuberculosis Conserved hypothetical protein 0.0182 0.0151 1
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.3089 0.2724 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0009 0.0195
Brugia malayi hypothetical protein 0.0117 0.0094 0.0129
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0006 0.0013
Brugia malayi neuropeptide F receptor 0.0447 0.0386 0.0531
Toxoplasma gondii HEAT repeat-containing protein 0.0065 0.0048 0.0176
Brugia malayi Dopamine receptor 0.0447 0.0386 0.0531
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0019 0.0007 0.0082
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0447 0.0386 0.4778
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0009 0.0153
Plasmodium falciparum glutathione reductase 0.0053 0.0037 0.0136
Brugia malayi hypothetical protein 0.0013 0.0001 0.0002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0008 0.0756
Entamoeba histolytica Ran family GTPase 0.0048 0.0033 0.3726
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0009 0.003
Entamoeba histolytica serine/threonine protein kinase, putative 0.0108 0.0086 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0059 0.0043 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0003 0.0249
Echinococcus granulosus g protein coupled receptor 0.0447 0.0386 0.4778
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0006 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.0007
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0048 0.0033 0.0045
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0074 0.0055 0.0199
Trichomonas vaginalis helicase, putative 0.0015 0.0003 0.0249
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0014 0.1581
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0074 0.0055 0.6418
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0447 0.0386 0.4778
Brugia malayi G protein-coupled receptor F59B2.13 0.0447 0.0386 0.0531
Echinococcus granulosus FTZ F1 alpha 0.0012 0 0.0005
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0009 0.0034
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.0007
Onchocerca volvulus 0.0447 0.0386 0.0386
Echinococcus multilocularis neuropeptide s receptor 0.0447 0.0386 0.4778
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0447 0.0386 0.4778
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0 0.0005
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0004 0.0055
Echinococcus granulosus rhodopsin orphan GPCR 0.0447 0.0386 0.4778
Schistosoma mansoni neuropeptide f receptor 76f 0.0447 0.0386 0.4778
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0003 0.0006
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0008 0.0099
Brugia malayi hypothetical protein 0.0447 0.0386 0.0531
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0447 0.0386 0.4778
Brugia malayi Dopamine receptor protein 2 0.0447 0.0386 0.0531
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0006 0.0077
Schistosoma mansoni hypothetical protein 0.0036 0.0022 0.0269
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0447 0.0386 0.4778
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0 0.0005
Plasmodium falciparum importin beta, putative 0.0065 0.0048 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0009 0.003
Echinococcus multilocularis G-protein coupled receptor, putative 0.0447 0.0386 0.4778
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0023 0.0011 0.0035
Echinococcus granulosus G protein coupled receptor 139 0.0447 0.0386 0.4778
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0059 0.6849
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0024
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0009 0.003
Echinococcus granulosus peptide allatostatin:somatostatin 0.0447 0.0386 0.4778
Loa Loa (eye worm) heterochromatin protein 1 0.0078 0.0059 0.0975
Echinococcus multilocularis fmrfamide receptor 0.0447 0.0386 0.4778
Echinococcus multilocularis protein C ets 2 0.0024 0.0011 0.0139
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0163 0.0135 0.0484
Echinococcus granulosus tm gpcr rhodopsin 0.0447 0.0386 0.4778
Leishmania major hypothetical protein, conserved 0.0017 0.0005 0.0015
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0074 0.0055 0.0193
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0006 0.0019
Plasmodium falciparum thioredoxin reductase 0.0053 0.0037 0.0136
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0447 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0447 0.0386 0.4778
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0006 0.0023
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0022 0.003
Schistosoma mansoni amine GPCR 0.0447 0.0386 0.4778
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0695 0.0606 1
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0024 0.0011 0.0139
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0048 0.0033 0.0404
Schistosoma mansoni biogenic amine receptor 0.0447 0.0386 0.4778
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0009 0.0152
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.0007
Schistosoma mansoni amine GPCR 0.0447 0.0386 0.4778
Echinococcus multilocularis orexin receptor type 2 0.0447 0.0386 0.4778
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0447 0.0386 0.0531
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0009 0.0115
Echinococcus granulosus somatostatin receptor 0.0447 0.0386 0.4778
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0006 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0018 0.1941
Toxoplasma gondii hypothetical protein 0.0056 0.0039 0.0145
Echinococcus granulosus fmrfamide receptor 0.0447 0.0386 0.4778
Schistosoma mansoni opsin-like receptor 0.0447 0.0386 0.4778
Giardia lamblia Kinase, PLK 0.0108 0.0086 0.0315
Schistosoma mansoni importin-beta 2 0.0012 0.0001 0.0014
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0003 0.0209
Loa Loa (eye worm) G-protein coupled receptor 0.0447 0.0386 0.6374
Echinococcus granulosus dro:myosuppressin receptor 0.0447 0.0386 0.4778
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0009 0.0114
Onchocerca volvulus 0.0447 0.0386 0.0386
Brugia malayi Telomerase reverse transcriptase 0.8221 0.7266 1
Echinococcus multilocularis ets variant gene 4 0.0024 0.0011 0.0139
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0164 0.0135 0.2229
Echinococcus granulosus dna polymerase eta 0.0022 0.0009 0.0115
Trypanosoma brucei polo-like protein kinase 0.0108 0.0086 0.0311
Trypanosoma brucei telomerase reverse transcriptase 0.3089 0.2724 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0009 0.003
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0006 0.0625
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0447 0.0386 0.4778
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0036 0.0451
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0006 0.0019
Echinococcus granulosus neuropeptide Y receptor 0.0447 0.0386 0.4778
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0 0.0005
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0006 0.0019
Echinococcus granulosus g-protein coupled receptor 0.0447 0.0386 0.4778
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0018 0.1941
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.0086 1
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.0007
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0 0.0005
Brugia malayi RE15519p 0.0447 0.0386 0.0531
Schistosoma mansoni growth hormone secretagogue receptor 0.0447 0.0386 0.4778
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0009 0.0115
Schistosoma mansoni ets-related 0.0497 0.043 0.5319
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0006 0.0013
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0006 0.0079
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0009 0.0023
Plasmodium falciparum transportin 0.0012 0.0001 0.0004
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0006 0.0077
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0006 0.0019
Echinococcus granulosus zinc finger protein 0.0026 0.0013 0.0159
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0003 0.0249
Plasmodium falciparum heterochromatin protein 1 0.0013 0.0001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0044 0.0029 0.0476
Brugia malayi G-protein coupled receptor 0.0447 0.0386 0.0531
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0003 0.0249
Loa Loa (eye worm) hypothetical protein 0.0045 0.003 0.0503
Mycobacterium tuberculosis Probable dehydrogenase 0.012 0.0097 0.6254
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0 0.0005
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0026 0.0318
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0053 0.0037 0.4236
Schistosoma mansoni bromodomain containing protein 0.0074 0.0056 0.0693
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0001 0.0018
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0016 0.0195
Echinococcus granulosus tm gpcr rhodopsin 0.0447 0.0386 0.4778
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0011 0.0041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0036 0.0451
Echinococcus granulosus rhodopsin orphan GPCR 0.0447 0.0386 0.4778
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Schistosoma mansoni amine GPCR 0.0447 0.0386 0.4778
Echinococcus granulosus neuropeptide receptor A26 0.0447 0.0386 0.4778
Schistosoma mansoni hypothetical protein 0.0117 0.0094 0.1163
Echinococcus multilocularis neuropeptide Y receptor 0.0447 0.0386 0.4778
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0024 0.0011 0.0185
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0009 0.003
Schistosoma mansoni DNA polymerase eta 0.0022 0.0009 0.0115
Brugia malayi latrophilin 2 splice variant baaae 0.0077 0.0058 0.008
Entamoeba histolytica hypothetical protein 0.0053 0.0037 0.4236
Schistosoma mansoni thyroid hormone receptor 0.0012 0 0.0005
Schistosoma mansoni rotamase 0.0075 0.0057 0.0705
Trypanosoma cruzi polo-like protein kinase, putative 0.0108 0.0086 0.0304
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0009 0.0013
Plasmodium falciparum thioredoxin reductase 0.0018 0.0006 0.0023
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0 0.0005
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0447 0.0386 0.4778
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0003 0.0008
Brugia malayi Importin beta-1 subunit 0.0065 0.0048 0.0066
Schistosoma mansoni amine GPCR 0.0447 0.0386 0.4778
Echinococcus granulosus ewsr:fli fusion protein type 0.0024 0.0011 0.0139
Echinococcus multilocularis cpg binding protein 0.0071 0.0053 0.0653
Schistosoma mansoni histamine h1 receptor 0.0447 0.0386 0.4778
Brugia malayi hypothetical protein 0.0117 0.0094 0.0129
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.0086 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0001 0.0043
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.0007
Onchocerca volvulus 0.0447 0.0386 0.0386
Echinococcus granulosus dnaJ subfamily B 0.0924 0.0808 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0447 0.0386 0.4778
Leishmania major GTP-binding protein, putative 0.0048 0.0033 0.0116
Schistosoma mansoni adenoreceptor 0.0447 0.0386 0.4778
Echinococcus multilocularis rhodopsin orphan GPCR 0.0447 0.0386 0.4778
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0447 0.0386 0.4778
Echinococcus multilocularis transportin 1 0.0012 0.0001 0.0014
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0447 0.0386 0.6374
Loa Loa (eye worm) histone methyltransferase 0.002 0.0008 0.0132
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0013 0.0001 0.0005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0009 0.0024
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0447 0.0386 0.4778
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0007 0.0087
Echinococcus multilocularis FTZ F1 alpha 0.0012 0 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0036 0.0451
Brugia malayi serine/threonine-protein kinase plk-2 0.0108 0.0086 0.0118
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0086 0.1061
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0009 0.0214
Brugia malayi transcription factor E74 isoform 0.0024 0.0011 0.0015
Brugia malayi glutathione reductase 0.0053 0.0037 0.0051
Loa Loa (eye worm) hypothetical protein 0.0079 0.006 0.0992
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0009 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0004 0.0055
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0014 0.0003 0.0034
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0009 0.003
Schistosoma mansoni zinc finger protein 0.0026 0.0013 0.0159
Echinococcus granulosus ETS transcription factor Elf 5 0.0024 0.0011 0.0139
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0009 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0001 0.0043
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Schistosoma mansoni ran 0.0048 0.0033 0.0404
Leishmania major trypanothione reductase 0.0053 0.0037 0.0132
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0006 0.0023
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0003 0.0209
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0001 0.0043
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0032 0.3619
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0075 0.0057 0.0941
Echinococcus multilocularis neuropeptide receptor 0.0447 0.0386 0.4778
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0006 0.0079
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0447 0.0386 0.4778
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0002 0.0003
Echinococcus granulosus allatostatin A receptor 0.0447 0.0386 0.4778
Brugia malayi MH2 domain containing protein 0.0133 0.0108 0.0149
Brugia malayi hypothetical protein 0.0447 0.0386 0.0531
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0037 0.0457
Schistosoma mansoni gabp alpha 0.0164 0.0135 0.1671
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0001 0.0043
Brugia malayi hypothetical protein 0.0447 0.0386 0.0531
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0006 0.0013
Echinococcus multilocularis neuropeptide Y receptor 0.0447 0.0386 0.4778
Schistosoma mansoni hypothetical protein 0.0036 0.0022 0.0269
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0 0.0005
Schistosoma mansoni biogenic amine receptor 0.0447 0.0386 0.4778
Trypanosoma cruzi ISWI complex protein 0.0017 0.0005 0.0009
Brugia malayi ecdysteroid receptor 0.0012 0 0.0001
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0006 0.0625
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0003 0.0249
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0001 0.0043
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0009 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0001 0.0043
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0 0.0005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0036 0.005
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0022 0.003
Echinococcus multilocularis bloom syndrome protein 0.0027 0.0014 0.0172
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0001 0.0018
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0134 0.0109 0.7075
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0048 0.0033 0.0109
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.0086 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0001 0.0043
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0007 0.0087
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0032 0.3619
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0009 0.003
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0447 0.0386 0.4778
Echinococcus multilocularis expressed protein 0.0075 0.0057 0.0705
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0009 0.0024
Onchocerca volvulus Serine\/threonine kinase homolog 0.0108 0.0086 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0001 0.0043
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Schistosoma mansoni hypothetical protein 0.0194 0.0162 0.1999
Brugia malayi Heterochromatin protein 1 0.0078 0.0059 0.0081
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0009 0.0024
Echinococcus multilocularis dna polymerase eta 0.0022 0.0009 0.0115
Schistosoma mansoni kinase 0.0055 0.0039 0.048
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0009 0.0023
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.0108 0.1786
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0075 0.0057 0.0078
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0009 0.0965
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0022 0.0269
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0014 0.1581
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0006 0.0019
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0 0.0005
Echinococcus multilocularis g protein coupled receptor 0.0447 0.0386 0.4778
Plasmodium falciparum glutathione reductase 0.0018 0.0006 0.0023
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0447 0.0386 0.4778
Echinococcus multilocularis chromobox protein 2 0.0013 0.0001 0.0018
Schistosoma mansoni hypothetical protein 0.0017 0.0005 0.0066
Brugia malayi Steroid receptor seven-up type 2 0.0012 0 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0009 0.003
Trypanosoma brucei unspecified product 0.0015 0.0003 0.0008
Echinococcus granulosus chromobox protein 1 0.0078 0.0059 0.0731
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0006 0.0009
Brugia malayi Calcitonin receptor-like protein seb-1 0.0113 0.009 0.0124
Schistosoma mansoni chromobox protein 0.0013 0.0001 0.0018
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0009 0.0115
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0447 0.0386 0.4778
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0022 0.0359
Echinococcus multilocularis ETS transcription factor Elf 2 0.0024 0.0011 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0009 0.003
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0447 0.0386 0.4778
Schistosoma mansoni ap endonuclease 0.0021 0.0009 0.0114
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0007 0.0087
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0 0.0005
Leishmania major DNA polymerase kappa, putative 0.0022 0.0009 0.003
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0447 0.0386 0.6374
Echinococcus granulosus rhodopsin orphan GPCR 0.0447 0.0386 0.4778
Schistosoma mansoni ap endonuclease 0.0021 0.0009 0.0114
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0006 0.0023
Mycobacterium tuberculosis Putative ferredoxin reductase 0.012 0.0097 0.6254
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0023 0.0011 1
Echinococcus granulosus protection of telomeres protein 1 0.0594 0.0516 0.6387
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0447 0.0386 0.4778
Echinococcus multilocularis allatostatin A receptor 0.0447 0.0386 0.4778
Echinococcus granulosus neuropeptides capa receptor 0.0447 0.0386 0.4778
Echinococcus granulosus dna polymerase kappa 0.0022 0.0009 0.0115
Loa Loa (eye worm) hypothetical protein 0.014 0.0114 0.1882
Loa Loa (eye worm) CXXC zinc finger family protein 0.0065 0.0048 0.0786
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0447 0.0386 0.4778
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.0007
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0006 0.0102
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0033 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0 0.0001
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.3089 0.2724 1
Toxoplasma gondii HEAT repeat-containing protein 0.0012 0.0001 0.0004
Brugia malayi steroid hormone receptor 0.0012 0 0.0001
Toxoplasma gondii thioredoxin reductase 0.0053 0.0037 0.0136
Brugia malayi M-phase phosphoprotein, mpp8 0.0013 0.0001 0.0002
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0001 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0 0.0007
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0008 0.0099
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Onchocerca volvulus 0.0447 0.0386 0.0386
Schistosoma mansoni hypothetical protein 0.0447 0.0386 0.4778
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0345 0.0296 0.1075
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0008 0.0103
Schistosoma mansoni hypothetical protein 0.0023 0.0011 0.0131
Echinococcus granulosus transportin 1 0.0012 0.0001 0.0014
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0001 0.0005
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0048 0.0033 0.0109
Echinococcus multilocularis chromobox protein 1 0.0078 0.0059 0.0731
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0019 0.0007 0.0082
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0006 0.0019
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0009 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0003 0.0249
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0009 0.0965
Schistosoma mansoni chromobox protein 0.0078 0.0059 0.0731
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0001 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0447 0.0386 0.4778
Brugia malayi PHD-finger family protein 0.0032 0.0018 0.0025
Trypanosoma brucei ISWI complex protein 0.0017 0.0005 0.0015
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0006 0.0023
Schistosoma mansoni neuropeptide receptor 0.0447 0.0386 0.4778
Brugia malayi Ets-domain containing protein 0.0164 0.0135 0.0186
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0014 0.1581
Schistosoma mansoni ran 0.0048 0.0033 0.0404
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Loa Loa (eye worm) hypothetical protein 0.0447 0.0386 0.6374
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0006 0.0019
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.0086 1
Schistosoma mansoni hypothetical protein 0.0447 0.0386 0.4778
Echinococcus multilocularis G protein coupled receptor 139 0.0447 0.0386 0.4778
Brugia malayi Bloom's syndrome protein homolog 0.0027 0.0014 0.0019
Brugia malayi Melatonin receptor type 1A 0.0447 0.0386 0.0531
Echinococcus granulosus bloom syndrome protein 0.0027 0.0014 0.0172
Echinococcus multilocularis ETS transcription factor Elf 5 0.0024 0.0011 0.0139
Echinococcus multilocularis g-protein coupled receptor 0.0447 0.0386 0.4778
Schistosoma mansoni hypothetical protein 0.0013 0.0001 0.0018
Entamoeba histolytica hypothetical protein 0.0013 0.0001 0.0043
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0022 0.0269

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 2.5 uM Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor ChEMBL. No reference
IC50 (binding) > 2.5 uM Binding affinity in Chinese hamster ovary (CHO) cells stably transfected with human endothelin B (ETB) receptor ChEMBL. No reference
IC50 (binding) > 2.5 uM Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor ChEMBL. No reference
IC50 (binding) > 2.5 uM Binding affinity in Chinese hamster ovary (CHO) cells stably transfected with human endothelin B (ETB) receptor ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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