TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 359.421 | Formula: C20H9NO2S2
H donors: 1 H acceptors: 2 LogP: 5.43 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: O=C1NC(=O)c2c1c1c3ccccc3sc1c1c2c2ccccc2s1
InChi: 1S/C20H9NO2S2/c22-19-15-13-9-5-1-3-7-11(9)24-17(13)18-14(16(15)20(23)21-19)10-6-2-4-8-12(10)25-18/h1-8H,(H,21,22,23)
InChiKey: CQEVJRRZNCUCAW-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase kinase kinase 9	Starlite/ChEMBL	References
Homo sapiens	mitogen-activated protein kinase kinase kinase 11	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	Get druggable targets OG5_128497	All targets in OG5_128497
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_128497	All targets in OG5_128497
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	Get druggable targets OG5_128497	All targets in OG5_128497

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0346	0.0253
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0035	0.0596	0.0505
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0175	0.0175
Echinococcus granulosus	Proteasome subunit alpha beta	0.0035	0.0596	0.0505
Brugia malayi	proteasome subunit beta type 3	0.0035	0.0596	0.0596
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0035	0.0596	0.0505
Leishmania major	proteasome alpha 2 subunit, putative	0.0035	0.0596	0.0258
Entamoeba histolytica	cysteine protease, putative	0.0023	0.0346	0.0253
Plasmodium vivax	proteasome subunit beta type-5, putative	0.046	1	1
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0035	0.0596	0.0596
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0035	0.0596	0.0258
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0035	0.0596	0.0505
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0346	0.0253
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0035	0.0596	0.0505
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0035	0.0596	0.0596
Trypanosoma brucei	proteasome beta 7 subunit	0.0035	0.0596	0.0505
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0346	0.0253
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0346	0.0346
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0035	0.0596	0.0596
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0035	0.0596	0.0596
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0035	0.0596	0.0505
Onchocerca volvulus		0.0023	0.0346	0.4069
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0035	0.0596	0.0505
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0035	0.0596	0.0505
Brugia malayi	proteasome subunit alpha type 6	0.0035	0.0596	0.0596
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0035	0.0596	0.0505
Echinococcus granulosus	cathepsin l1	0.0023	0.0346	0.0253
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0023	0.0346	0.0346
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0035	0.0596	0.0505
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0346	0.0346
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0035	0.0596	0.0596
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0035	0.0596	0.0258
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0012	0.0095	0.0095
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0035	0.0596	0.0505
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0035	0.0596	0.0596
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0175	0.0175
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0035	0.0596	0.0596
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0035	0.0596	0.0505
Loa Loa (eye worm)	cysteine protease	0.0023	0.0346	0.0346
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0035	0.0596	0.0505
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0035	0.0596	0.0505
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0175	0.0081
Leishmania major	proteasome beta 2 subunit, putative	0.0035	0.0596	0.0258
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0346	0.0253
Leishmania major	proteasome alpha 1 subunit, putative	0.0035	0.0596	0.0258
Onchocerca volvulus		0.0023	0.0346	0.4069
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0035	0.0596	0.0596
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0346	0.0253
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0035	0.0596	0.0596
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.046	1	1
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0035	0.0596	0.0596
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0346	0.0253
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0346	0.0253
Plasmodium vivax	vivapain-3	0.0012	0.0095	0.0095
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0035	0.0596	0.0505
Trypanosoma cruzi	20S proteasome subunit	0.0035	0.0596	0.0596
Trypanosoma cruzi	cysteine peptidase, putative	0.0023	0.0346	0.0346
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0035	0.0596	0.0505
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0035	0.0596	0.0596
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.046	1	1
Brugia malayi	proteasome subunit beta type 2	0.0035	0.0596	0.0596
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.046	1	1
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0035	0.0596	0.0596
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0035	0.0596	0.0505
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0035	0.0596	0.0596
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.046	1	1
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0035	0.0596	0.0596
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0023	0.0346	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0175	0.0175
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0035	0.0596	0.0596
Onchocerca volvulus		0.0023	0.0346	0.4069
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0346	0.0253
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0035	0.0596	0.0505
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0035	0.0596	0.0258
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0035	0.0596	0.0505
Trypanosoma cruzi	cruzipain precursor, putative	0.0023	0.0346	0.0346
Toxoplasma gondii	heat shock protein hslv, putative	0.0035	0.0596	0.0258
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.0035	0.0596	0.0505
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0346	0.0253
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0035	0.0596	0.0596
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0035	0.0596	0.0505
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0346	0.0253
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0035	0.0596	0.0596
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0346	0.0253
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0346	0.0253
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0023	0.0346	0.0253
Trypanosoma cruzi	cysteine proteinase, putative	0.0012	0.0095	0.0095
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0035	0.0596	0.0596
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0023	0.0346	0.0253
Brugia malayi	Papain family cysteine protease containing protein	0.0012	0.0095	0.0095
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0035	0.0596	0.0596
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.046	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0346	0.0253
Loa Loa (eye worm)	PAS-3 protein	0.0035	0.0596	0.0596
Trypanosoma cruzi	cysteine proteinase, putative	0.0012	0.0095	0.0095
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0035	0.0596	0.0596
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0035	0.0596	0.0596
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0035	0.0596	0.0505
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0035	0.0596	0.0505
Plasmodium falciparum	proteasome subunit alpha type-1, putative	0.0035	0.0596	0.0505
Echinococcus granulosus	proteasome prosome macropain	0.046	1	1
Leishmania major	proteasome beta-1 subunit, putative	0.0035	0.0596	0.0258
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0035	0.0596	0.0505
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0346	0.0253
Brugia malayi	20S proteasome alpha5 subunit	0.0035	0.0596	0.0596
Echinococcus granulosus	proteasome subunit alpha type 2	0.0035	0.0596	0.0505
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0035	0.0596	0.0505
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0346	0.0253
Echinococcus granulosus	proteasome subunit alpha type 6	0.0035	0.0596	0.0505
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0346	0.0253
Trypanosoma cruzi	cysteine peptidase, putative	0.0023	0.0346	0.0346
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0012	0.0095	0.0095
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0035	0.0596	0.0596
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0175	0.0175
Onchocerca volvulus		0.0023	0.0346	0.4069
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0035	0.0596	0.0596
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0035	0.0596	0.0596
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0035	0.0596	0.0596
Echinococcus multilocularis	cysteine protease	0.0023	0.0346	0.0253
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0035	0.0596	0.0596
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0346	0.0253
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0023	0.0346	0.0253
Plasmodium falciparum	proteasome subunit alpha type-7, putative	0.0035	0.0596	0.0505
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0035	0.0596	0.0596
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0346	0.0253
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0035	0.0596	0.0505
Plasmodium falciparum	proteasome subunit beta type-4	0.0035	0.0596	0.0505
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0346	0.0253
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0035	0.0596	0.0505
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0035	0.0596	0.0505
Brugia malayi	cathepsin L-like precursor	0.0016	0.0175	0.0175
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0035	0.0596	0.0258
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0035	0.0596	0.0505
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0035	0.0596	0.0258
Echinococcus multilocularis	cysteine protease	0.0023	0.0346	0.0253
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0035	0.0596	0.0505
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0035	0.0596	0.0505
Plasmodium falciparum	proteasome subunit alpha type-6, putative	0.0035	0.0596	0.0505
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0035	0.0596	0.0505
Leishmania major	proteasome alpha 3 subunit, putative	0.0035	0.0596	0.0258
Entamoeba histolytica	cysteine proteinase, putative	0.0023	0.0346	0.0253
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0035	0.0596	0.0505
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0012	0.0095	0.0095
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0023	0.0346	0.0253
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0035	0.0596	0.0596
Brugia malayi	Proteasome A-type and B-type family protein	0.0035	0.0596	0.0596
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0035	0.0596	0.0596
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.0035	0.0596	0.0505
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0035	0.0596	0.0596
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0346	0.0253
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0035	0.0596	0.0596
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0175	0.0175
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0035	0.0596	0.0596
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0035	0.0596	0.0596
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0346	0.0253
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0012	0.0095	0.0095
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0035	0.0596	0.0596
Plasmodium vivax	unspecified product	0.0012	0.0095	0.0095
Toxoplasma gondii	proteasome subunit	0.0035	0.0596	0.0258
Schistosoma mansoni	cathepsin F (C01 family)	0.0023	0.0346	0.0346
Plasmodium falciparum	proteasome subunit beta type-5	0.046	1	1
Toxoplasma gondii	proteasome beta subunit	0.0035	0.0596	0.0258
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0035	0.0596	0.0505
Brugia malayi	Proteasome subunit alpha type 7-1	0.0035	0.0596	0.0596
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0023	0.0346	0.0253
Trypanosoma brucei	proteasome beta 6 subunit	0.0035	0.0596	0.0505
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0346	0.0346
Entamoeba histolytica	cysteine proteinase, putative	0.0023	0.0346	0.0253
Brugia malayi	proteasome subunit beta type 1	0.0035	0.0596	0.0596
Brugia malayi	Proteasome A-type and B-type family protein	0.0035	0.0596	0.0596
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0224	0.4792	0.4741
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0016	0.0175	0.0175
Toxoplasma gondii	proteasome subunit beta type, putative	0.046	1	1
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0346	0.0346
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0035	0.0596	0.0505
Plasmodium falciparum	proteasome subunit alpha type-2, putative	0.0035	0.0596	0.0505
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0035	0.0596	0.0596
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0346	0.0253
Plasmodium falciparum	proteasome subunit alpha type-3, putative	0.0035	0.0596	0.0505
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.0035	0.0596	0.0505
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0035	0.0596	0.0596
Onchocerca volvulus	Notchless protein homolog	0.0035	0.0596	1
Brugia malayi	proteasome subunit alpha type 2	0.0035	0.0596	0.0596
Brugia malayi	proteasome subunit alpha type 1	0.0035	0.0596	0.0596
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.0035	0.0596	0.0258
Leishmania major	proteasome beta 3 subunit, putative	0.0035	0.0596	0.0258
Brugia malayi	Proteasome A-type and B-type family protein	0.0035	0.0596	0.0596
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0035	0.0596	0.0258
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0023	0.0346	0.0253
Onchocerca volvulus		0.0023	0.0346	0.4069
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0346	0.0346
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0035	0.0596	0.0596
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0035	0.0596	0.0258
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0346	0.0253
Schistosoma mansoni	cathepsin F (C01 family)	0.0023	0.0346	0.0346
Plasmodium falciparum	proteasome subunit alpha type-4, putative	0.0035	0.0596	0.0505
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0346	0.0253
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0035	0.0596	0.0505
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0035	0.0596	0.0258
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0035	0.0596	0.0596
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0035	0.0596	0.0596
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.0035	0.0596	0.0505
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0346	0.0253
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0346	0.0253
Onchocerca volvulus	Cathepsin L homolog	0.0023	0.0346	0.4069
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0035	0.0596	0.0505
Plasmodium vivax	vivapain-1	0.0012	0.0095	0.0095
Onchocerca volvulus	Cathepsin L homolog	0.0023	0.0346	0.4069
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0035	0.0596	0.0505
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0346	0.0253
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0035	0.0596	0.0596
Plasmodium vivax	vivapain-2	0.0023	0.0346	0.0346
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0035	0.0596	0.0596
Leishmania major	proteasome beta 7 subunit, putative	0.0035	0.0596	0.0258
Onchocerca volvulus		0.0023	0.0346	0.4069
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0346	0.0253
Leishmania major	proteasome beta 2 subunit, putative	0.0035	0.0596	0.0258
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.046	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0023	0.0346	0.0346
Leishmania major	proteasome beta 5 subunit, putative	0.046	1	1
Trypanosoma brucei	proteasome alpha 7 subunit	0.0035	0.0596	0.0505
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0035	0.0596	0.0596
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0346	0.0253
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0035	0.0596	0.0596
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0035	0.0596	0.0596
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0035	0.0596	0.0596
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0035	0.0596	0.0258
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0035	0.0596	0.0596
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0035	0.0596	0.0505
Plasmodium falciparum	proteasome subunit beta type-3, putative	0.0035	0.0596	0.0505
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0023	0.0346	0.0253
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0023	0.0346	0.0346
Echinococcus granulosus	proteasome subunit beta type 7	0.0035	0.0596	0.0505
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0035	0.0596	0.0258
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0035	0.0596	0.0505
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.046	1	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0023	0.0346	0.0253
Onchocerca volvulus	Cathepsin F homolog	0.0023	0.0346	0.4069
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0035	0.0596	0.0505
Plasmodium falciparum	proteasome subunit alpha type-5, putative	0.0035	0.0596	0.0505
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0035	0.0596	0.0505
Leishmania major	proteasome alpha 7 subunit, putative	0.0035	0.0596	0.0258
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0035	0.0596	0.0596
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0035	0.0596	0.0258
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0035	0.0596	0.0596
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0035	0.0596	0.0258
Plasmodium falciparum	ATP-dependent protease subunit ClpQ	0.0035	0.0596	0.0505
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.046	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0346	0.0253
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0035	0.0596	0.0505
Brugia malayi	Proteasome subunit alpha type 1	0.0035	0.0596	0.0596
Echinococcus granulosus	proteasome subunit beta t family	0.0035	0.0596	0.0505
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0035	0.0604	0.0513
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0224	0.4792	0.4741
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0035	0.0596	0.0505
Brugia malayi	Papain family cysteine protease containing protein	0.0023	0.0346	0.0346
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0035	0.0596	0.0505
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.0035	0.0596	0.0505
Plasmodium falciparum	proteasome subunit beta type-6, putative	0.0035	0.0596	0.0505
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0035	0.0596	0.0596
Echinococcus multilocularis	cathepsin L cysteine protease	0.0023	0.0346	0.0253
Echinococcus multilocularis	cathepsin L cysteine protease	0.0023	0.0346	0.0253
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0035	0.0596	0.0596
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0035	0.0596	0.0505
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.046	1	1
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0035	0.0596	0.0505
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0035	0.0596	0.0596
Plasmodium vivax	vivapain-2	0.0023	0.0346	0.0346
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0175	0.0081
Brugia malayi	proteasome subunit alpha type 4	0.0035	0.0596	0.0596
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0035	0.0596	0.0505
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0175	0.0081
Mycobacterium ulcerans	proteasome PrcB	0.046	1	1
Echinococcus multilocularis	proteasome subunit beta type 6	0.0035	0.0596	0.0505
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0035	0.0596	0.0596
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0035	0.0596	0.0505
Echinococcus multilocularis	proteasome subunit beta type 7	0.0035	0.0596	0.0505
Onchocerca volvulus		0.0023	0.0346	0.4069
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0035	0.0596	0.0505
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0035	0.0596	0.5
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0035	0.0596	0.0596
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0035	0.0596	0.0505
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0035	0.0596	0.0596
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0035	0.0596	0.0596
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0035	0.0596	0.0505
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0346	0.0346
Brugia malayi	Papain family cysteine protease containing protein	0.0012	0.0095	0.0095
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0035	0.0596	0.0258
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0035	0.0596	0.0505
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0035	0.0596	0.0596
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0035	0.0596	0.0505
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.0035	0.0596	0.0258
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0035	0.0596	0.0596
Trypanosoma cruzi	cysteine peptidase, putative	0.0012	0.0095	0.0095
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0035	0.0596	0.0596
Brugia malayi	proteasome subunit alpha type 3	0.0035	0.0596	0.0596
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0035	0.0596	0.0505
Schistosoma mansoni	serine/threonine protein kinase	0.0218	0.465	0.465
Echinococcus granulosus	cathepsin l1	0.0016	0.0175	0.0081
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0035	0.0596	0.0596
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0346	0.0346
Schistosoma mansoni	tyrosine kinase	0.0008	0.0008	0.0008
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0035	0.0596	0.0258
Echinococcus granulosus	proteasome subunit beta type 6	0.0035	0.0596	0.0505
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0035	0.0596	0.0505
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0035	0.0596	0.0596
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0346	0.0253
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0035	0.0596	0.0505
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0035	0.0596	0.0596
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0346	0.0253
Leishmania major	proteasome alpha 1 subunit, putative	0.0035	0.0596	0.0258
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0035	0.0596	0.0596
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0035	0.0596	0.0596
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0175	0.0175
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0016	0.0175	0.0175
Loa Loa (eye worm)	fibroinase	0.0023	0.0346	0.0346
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.0035	0.0596	0.0505
Leishmania major	proteasome alpha 7 subunit, putative	0.0035	0.0596	0.0258
Plasmodium falciparum	proteasome subunit beta type-7, putative	0.0035	0.0596	0.0505
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0035	0.0596	0.0258
Trypanosoma cruzi	cysteine peptidase, putative	0.0023	0.0346	0.0346
Toxoplasma gondii	peptidase, T1 family protein	0.0035	0.0596	0.0258
Trypanosoma cruzi	cysteine protease, putative	0.0012	0.0095	0.0095
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0035	0.0596	0.0596
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0346	0.0253
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0023	0.0346	0.0253
Echinococcus multilocularis	proteasome (prosome, macropain)	0.046	1	1
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0035	0.0596	0.0505
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0035	0.0596	0.0505
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0035	0.0596	0.0596
Loa Loa (eye worm)	ctsf protein	0.0023	0.0346	0.0346
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0035	0.0596	0.0596
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0035	0.0596	0.0596
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0035	0.0596	0.0596
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0035	0.0596	0.0505
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.0035	0.0596	0.0505
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0035	0.0596	0.0258
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.046	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 300 nM	Inhibition of GST-MLK1 expressed in baculovirus	ChEMBL.	17266195
IC50 (binding)	> 300 nM	Inhibition of GST-MLK3 expressed in baculovirus	ChEMBL.	17266195
IC50 (binding)	> 300 nM	Inhibition of GST-MLK1 expressed in baculovirus	ChEMBL.	17266195
IC50 (binding)	> 300 nM	Inhibition of GST-MLK3 expressed in baculovirus	ChEMBL.	17266195

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL375139
PubChem: 16105513

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 411471