Detailed information for compound 412301

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 361.391 | Formula: C17H16FN3O3S
  • H donors: 2 H acceptors: 4 LogP: 3.26 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)CNC(=O)c1c(O)c2ncsc2n(c1=O)C(C)C
  • InChi: 1S/C17H16FN3O3S/c1-9(2)21-16(24)12(14(22)13-17(21)25-8-20-13)15(23)19-7-10-3-5-11(18)6-4-10/h3-6,8-9,22H,7H2,1-2H3,(H,19,23)
  • InChiKey: UHFCJKJXWGHXHK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans hypothetical protein 0.0166 0.1792 0.4728
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.003
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.1029 0.8702
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0331 0.3777 1
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0238 0.0628
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.1057 0.2796
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.002 0.0026 0.0069
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0221 0.0585
Schistosoma mansoni transcription factor LCR-F1 0.0115 0.1174 0.1341
Schistosoma mansoni hypothetical protein 0.0033 0.019 0.0202
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0088 0.023
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0019 0.0016 0.0011
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0569 0.0568
Leishmania major chloride channel protein, putative 0.002 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0047
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0115 0.1174 0.1173
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0385 0.0384
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0019 0.0016 0.0011
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0656 0.1734
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.1299 0.341
Trypanosoma cruzi chloride channel protein, putative 0.002 0.0026 0.0026
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0019 0.0018 0.0003
Leishmania major inosine-5-monophosphate dehydrogenase 0.0331 0.3777 1
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0238 0.059
Mycobacterium ulcerans hypothetical protein 0.0025 0.0088 0.02
Leishmania major mitochondrial DNA polymerase beta 0.0315 0.3592 0.9508
Brugia malayi cytochrome P450 0.0019 0.0016 0.0041
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.003
Schistosoma mansoni hypothetical protein 0.0357 0.4098 0.4729
Echinococcus multilocularis neuroglian 0.0019 0.002 0.0019
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0019 0.0016 0.0043
Mycobacterium tuberculosis Conserved hypothetical protein 0.0166 0.1792 0.4745
Loa Loa (eye worm) GMP reductase 0.0137 0.1446 0.3828
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0097 0.0955 0.2495
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0324 0.0818
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0129 0.0299
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.1057 0.2796
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0097 0.0955 0.2495
Brugia malayi Prion-like- 0.0019 0.002 0.0051
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.0238 0.1626
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.019 0.0219
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0331 0.3777 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.003
Loa Loa (eye worm) TK/KIN16 protein kinase 0.003 0.0149 0.0392
Onchocerca volvulus 0.005 0.0396 0.2736
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0137 0.1446 0.3828
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0321 0.037
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.003
Echinococcus multilocularis dual specificity 0.0097 0.0955 0.0954
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0569 0.1469
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0056 0.0106
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0088 0.028
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0137 0.1446 0.3828
Schistosoma mansoni nephrin 0.0032 0.0175 0.0183
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.002 0.0026 0.0026
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0019 0.0016 0.0011
Echinococcus multilocularis geminin 0.0357 0.4098 0.4098
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0084 0.0179
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.0435 0.0434
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0019 0.0016 0.0043
Schistosoma mansoni inositol monophosphatase 0.004 0.0271 0.0296
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.019 0.0501
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0238 0.6861
Loa Loa (eye worm) IMP dehydrogenase 1 0.0331 0.3777 1
Brugia malayi hypothetical protein 0.0115 0.1174 0.3106
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.1147 0.3037
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0385 0.0979
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0066
Entamoeba histolytica protein kinase domain containing protein 0.0097 0.0955 0.8039
Brugia malayi beta-NAC-like protein 0.0037 0.0238 0.0628
Echinococcus granulosus Niemann Pick C1 protein 0.0147 0.1561 0.1804
Mycobacterium ulcerans transcriptional regulator 0.002 0.0026 0.0037
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0019 0.002 0.0022
Echinococcus granulosus contactin 0.0019 0.002 0.0022
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0097 0.0955 0.2495
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0051
Entamoeba histolytica hypothetical protein 0.0024 0.0084 0.0243
Trypanosoma brucei GMP reductase 0.0331 0.3777 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0324 0.0818
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0051
Brugia malayi Importin beta-1 subunit 0.003 0.0152 0.0401
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.1147 0.3007
Brugia malayi Latrophilin receptor protein 2 0.0033 0.019 0.0501
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.002 0.0026 0.0069
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0955 0.1087
Echinococcus granulosus twitchin 0.0032 0.0181 0.0208
Leishmania major basic transcription factor 3a, putative 0.0037 0.0238 0.059
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.002 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0082 0.0774 0.2047
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0088 0.02
Echinococcus multilocularis tyrosine protein kinase otk 0.0019 0.002 0.0019
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.1147 0.3037
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0088 0.028
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0238 0.059
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0149 0.1589 0.4181
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0311 0.354 0.9371
Loa Loa (eye worm) hypothetical protein 0.0103 0.1029 0.2722
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0271 0.0271
Echinococcus granulosus Immunoglobulin 0.0019 0.0018 0.002
Toxoplasma gondii CBS family protein 0.002 0.0026 0.0026
Trypanosoma brucei trypanothione reductase 0.0049 0.0385 0.0979
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.002 0.0051
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.002 0.0026 0.0025
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.1589 0.4181
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0019 0.0016 0.0011
Entamoeba histolytica hypothetical protein 0.0115 0.1174 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0051
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0311 0.354 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0082 0.0774 0.2014
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0019 0.0016 0.0043
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0271 0.0679
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0025 0.0093 0.0107
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0019 0.0016 0.0011
Brugia malayi CHE-14 protein 0.0044 0.0321 0.0848
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0324 0.0818
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0019 0.002 0.0051
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.1147 0.3037
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.1057 0.2796
Plasmodium falciparum protein MAM3, putative 0.002 0.0026 0.0039
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0019 0.0016 0.0011
Echinococcus granulosus lachesin 0.0019 0.002 0.0022
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0051
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0088 0.019
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.0435 0.1112
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0569 0.064
Brugia malayi Thioredoxin reductase 0.0049 0.0385 0.1016
Chlamydia trachomatis GutQ/KpsF family sugar-phosphate isomerase 0.002 0.0026 0.0181
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0019 0.0016 0.0011
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0088 0.028
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0047
Brugia malayi Cytochrome P450 family protein 0.0019 0.0016 0.0041
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0271 0.0679
Loa Loa (eye worm) hypothetical protein 0.0054 0.0441 0.1165
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0019 0.002 0.0019
Echinococcus multilocularis Niemann Pick C1 protein 0.0147 0.1561 0.156
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.1147 0.3037
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.002 0.0026 0.0029
Schistosoma mansoni ran 0.0022 0.0056 0.0046
Echinococcus granulosus roundabout 2 0.0038 0.0249 0.0287
Loa Loa (eye worm) hypothetical protein 0.0025 0.0088 0.023
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0774 0.2014
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0019 0.0016 0.0011
Loa Loa (eye worm) inositol-1 0.004 0.0271 0.0717
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.002 0.0026 0.0029
Brugia malayi Fibronectin type III domain containing protein 0.0019 0.0018 0.0047
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0019 0.002 0.0019
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0019 0.0016 0.0043
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0321 0.0848
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0331 0.3777 1
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.002 0.0026 0.0011
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0774 0.2014
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.1147 0.3037
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0331 0.3777 0.3777
Toxoplasma gondii CBS domain-containing protein 0.002 0.0026 0.0026
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0019 0.0016 0.0043
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0157 0.1683 0.4438
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0088 0.023
Echinococcus granulosus H:Cl exchange transporter 3 0.002 0.0026 0.0029
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0019 0.0016 0.0043
Brugia malayi CBS domain containing protein 0.002 0.0026 0.0066
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0019 0.002 0.0019
Brugia malayi Cytochrome P450 family protein 0.0028 0.0129 0.0339
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.002 0.0026 0.0069
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0396 0.1048
Schistosoma mansoni survival motor neuron protein 0.005 0.0396 0.044
Chlamydia trachomatis CBS domain-containing protein 0.002 0.0026 0.0181
Loa Loa (eye worm) hypothetical protein 0.0105 0.1057 0.2796
Echinococcus multilocularis roundabout 2 0.0038 0.0249 0.0249
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.002 0.0051
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0056 0.0125
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0152 0.0361
Chlamydia trachomatis Mg++ transporter 0.002 0.0026 0.0181
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.002 0.0026 0.0011
Echinococcus granulosus neuropeptide receptor A26 0.0495 0.5757 0.6656
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0066
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0012 0.0032
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.002 0.0051
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0097 0.0955 0.2495
Loa Loa (eye worm) hypothetical protein 0.0096 0.0949 0.251
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0084 0.1027
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.002 0.0026 0.0069
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0271 0.0679
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0019 0.0018 0.0018
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0019 0.0016 0.0043
Entamoeba histolytica hypothetical protein 0.0115 0.1174 1
Brugia malayi hypothetical protein 0.0247 0.2767 0.7324
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0569 0.1506
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.002 0.0026 0.0069
Leishmania major importin beta-1 subunit, putative 0.0024 0.0084 0.0179
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0271 0.0655
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0047
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0088 0.023
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0271 0.0679
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0019 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0038 0.0249 0.0658
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0051
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0082 0.0774 0.0773
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0331 0.3777 1
Echinococcus granulosus H:Cl exchange transporter 4 0.002 0.0026 0.0029
Schistosoma mansoni hypothetical protein 0.0321 0.3665 0.4227
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.019 0.0189
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0019 0.0016 0.0043
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0569 0.1478
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0271 0.8126
Plasmodium falciparum glutathione reductase 0.0049 0.0385 0.1055
Mycobacterium tuberculosis Conserved protein 0.002 0.0026 0.0069
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.1589 0.4181
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0271 0.0679
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0774 0.2159
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0238 0.6861
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0019 0.0016 0.0011
Leishmania major chloride channel protein, putative 0.002 0.0026 0.0026
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.002 0.0026 0.0026
Plasmodium vivax importin-beta 2, putative 0.003 0.0152 0.0397
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.0016 0.0018
Schistosoma mansoni cell adhesion molecule 0.0019 0.002 0.0004
Brugia malayi loechrig isoform VII 0.002 0.0026 0.0066
Echinococcus multilocularis lachesin 0.0019 0.002 0.0019
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.1029 0.2722
Entamoeba histolytica hypothetical protein 0.0115 0.1174 1
Echinococcus granulosus snurportin 1 0.0321 0.3665 0.4237
Onchocerca volvulus Putative GMP reductase 0.0137 0.1446 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0088 0.019
Echinococcus multilocularis Immunoglobulin 0.0019 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0051
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0331 0.3777 0.4367
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0082 0.0774 0.1994
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0238 0.6861
Loa Loa (eye worm) cytochrome P450 0.0019 0.0016 0.0041
Loa Loa (eye worm) hypothetical protein 0.0038 0.0249 0.0658
Trypanosoma cruzi GMP reductase 0.0331 0.3777 1
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0152 0.0361
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0569 0.0657
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0019 0.0016 0.0043
Echinococcus multilocularis neuropeptide s receptor 0.0495 0.5757 0.5756
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0056 0.0106
Schistosoma mansoni hypothetical protein 0.0043 0.0302 0.0331
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0774 0.2023
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0088 0.0232
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0315 0.3592 0.9508
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0056 0.0106
Echinococcus granulosus tyrosine protein kinase otk 0.0019 0.002 0.0022
Leishmania major guanosine monophosphate reductase 0.0331 0.3777 1
Schistosoma mansoni nephrin 0.0019 0.002 0.0004
Brugia malayi GMP reductase 0.0137 0.1446 0.3828
Schistosoma mansoni hypothetical protein 0.0043 0.0302 0.0331
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.1029 0.1028
Schistosoma mansoni ran 0.0022 0.0056 0.0046
Brugia malayi Peroxidasin 0.0019 0.002 0.0051
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0056 0.0147
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0152 0.0361
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.1048 0.1195
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0019 0.0016 0.0043
Brugia malayi glutathione reductase 0.0049 0.0385 0.1016
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0019 0.0016 0.0043
Loa Loa (eye worm) glutathione reductase 0.0049 0.0385 0.1016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0047
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0056 0.0064
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0315 0.3592 0.9508
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0129 0.0339
Brugia malayi Cytochrome P450 family protein 0.0028 0.0129 0.0339
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0321 1
Plasmodium vivax glutathione reductase, putative 0.0049 0.0385 0.1055
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0088 0.02
Schistosoma mansoni septate junction protein 0.0019 0.002 0.0004
Toxoplasma gondii IMP dehydrogenas 0.0331 0.3777 1
Trypanosoma cruzi chloride channel protein, putative 0.002 0.0026 0.0026
Brugia malayi RNA, U transporter 1 0.0086 0.0822 0.2173
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0321 0.037
Schistosoma mansoni hypothetical protein 0.0033 0.019 0.0202
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0088 0.019
Loa Loa (eye worm) hypothetical protein 0.0096 0.0949 0.251
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0019 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0025 0.0088 0.023
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0238 0.064
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0019 0.002 0.0019
Brugia malayi ancient conserved domain protein 4 0.002 0.0026 0.0066
Brugia malayi Probable ClpP-like protease 0.0082 0.0774 0.2047
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0019 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.003 0.0152 0.0401
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0088 0.02
Echinococcus multilocularis protein dispatched 1 0.005 0.0396 0.0395
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0019 0.0016 0.0011
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0315 0.3592 0.9508
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0129 0.0299
Loa Loa (eye worm) hypothetical protein 0.0018 0.0012 0.003
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.019 0.0501
Brugia malayi chloride channel protein 7 0.002 0.0026 0.0066
Echinococcus granulosus roundabout 2 0.0019 0.002 0.0022
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.002 0.0026 0.0025
Schistosoma mansoni cell adhesion molecule 0.0025 0.0093 0.0089
Schistosoma mansoni peptidase Clp (S14 family) 0.0082 0.0774 0.0878
Mycobacterium tuberculosis Conserved protein 0.002 0.0026 0.0069
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.1299 0.3439
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0441 0.1129
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0569 0.1478
Echinococcus granulosus neuropeptide s receptor 0.0495 0.5757 0.6656
Echinococcus granulosus GPCR family 2 0.0033 0.019 0.0219
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.002 0.0051
Echinococcus granulosus geminin 0.0357 0.4098 0.4738
Schistosoma mansoni tyrosine kinase 0.0024 0.0076 0.0069
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.002 0.0026 0.0025
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0385 0.1016
Loa Loa (eye worm) hypothetical protein 0.0033 0.019 0.0501
Loa Loa (eye worm) chloride channel protein 7 0.002 0.0026 0.0066
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0321 0.032
Schistosoma mansoni inositol monophosphatase 0.004 0.0271 0.0296
Loa Loa (eye worm) chloride channel 3 0.002 0.0026 0.0066
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0221 0.0544
Loa Loa (eye worm) hypothetical protein 0.0044 0.0321 0.0848
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.1299 0.3439
Schistosoma mansoni cell adhesion molecule 0.0019 0.002 0.0004
Echinococcus multilocularis GPCR, family 2 0.0033 0.019 0.0189
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0149 0.0392
Toxoplasma gondii CBS domain-containing protein 0.002 0.0026 0.0026
Echinococcus granulosus neuroglian 0.0032 0.0175 0.0201
Echinococcus multilocularis Immunoglobulin 0.0019 0.0018 0.0018
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0157 0.1683 0.4432
Trypanosoma cruzi chloride channel protein, putative 0.002 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0051
Brugia malayi hypothetical protein 0.0019 0.0018 0.0047
Trypanosoma cruzi GMP reductase 0.0331 0.3777 1
Toxoplasma gondii hypothetical protein 0.0051 0.0402 0.1027
Echinococcus multilocularis roundabout 2 0.0019 0.002 0.0019
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.002 0.0026 0.0067
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0056 0.0106
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.002 0.0026 0.0069
Mycobacterium tuberculosis Probable reductase 0.0113 0.1147 0.3037
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0088 0.02
Echinococcus multilocularis neuropeptide receptor A26 0.0495 0.5757 0.5756
Schistosoma mansoni chloride channel protein 0.002 0.0026 0.0011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0088 0.0232
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0238 0.059
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0128 0.0329
Mycobacterium tuberculosis Conserved protein 0.002 0.0026 0.0069
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0115 0.1174 0.1356
Schistosoma mansoni titin 0.0019 0.002 0.0004
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0088 0.019
Leishmania major CBS domain protein, conserved 0.002 0.0026 0.0026
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0019 0.002 0.0051
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0774 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0019 0.0016 0.0043
Echinococcus multilocularis expressed conserved protein 0.0097 0.0954 0.0953
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.1299 0.3439
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0097 0.0955 0.2526
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.2767 0.2766
Schistosoma mansoni hypothetical protein 0.0115 0.1174 0.1341
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0311 0.354 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0129 0.031
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0271 0.0689
Echinococcus granulosus transcription factor btf3 0.0037 0.0238 0.0274
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0238 0.059
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0128 0.0329
Toxoplasma gondii thioredoxin reductase 0.0049 0.0385 0.0979
Brugia malayi Protein kinase domain containing protein 0.0097 0.0955 0.2526
Echinococcus multilocularis snurportin 1 0.0321 0.3665 0.3665
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0331 0.3777 1
Echinococcus granulosus roundabout 2 0.0019 0.002 0.0022
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0019 0.002 0.0004
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0019 0.0016 0.0043
Echinococcus granulosus dual specificity 0.0097 0.0955 0.1103
Mycobacterium leprae conserved hypothetical protein 0.002 0.0026 0.0026
Leishmania major cytochrome p450-like protein 0.0028 0.0129 0.0299
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0774 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0569 0.1478
Entamoeba histolytica hypothetical protein 0.0037 0.0238 0.1626
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0019 0.0016 0.0043
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.019 0.0189
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0019 0.0016 0.0043
Schistosoma mansoni patched 1 0.0044 0.0321 0.0353
Echinococcus granulosus microtubule associated protein 2 0.0734 0.8649 1
Schistosoma mansoni transcription factor btf3 0.0037 0.0238 0.0257
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0088 0.02
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.002 0.0026 0.0025
Echinococcus multilocularis microtubule associated protein 2 0.0734 0.8649 0.8649
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0019 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0066
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0128 0.137
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0506 0.1338
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0019 0.0016 0.0011
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.002 0.0051
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.0435 0.0501
Plasmodium falciparum importin beta, putative 0.003 0.0152 0.0397
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0019 0.0016 0.0011
Schistosoma mansoni hypothetical protein 0.0072 0.0656 0.0741
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.0435 0.115
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0331 0.3777 1
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0238 0.064
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0331 0.3777 0.4357
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.002 0.0026 0.0025
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0019 0.0016 0.0011
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0056 0.0147
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0324 0.0818
Schistosoma mansoni hypothetical protein 0.005 0.0396 0.044
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0385 0.1055
Schistosoma mansoni hypothetical protein 0.0043 0.0302 0.0331
Brugia malayi ancient conserved domain protein 2 0.002 0.0026 0.0066
Echinococcus multilocularis roundabout 2 0.0019 0.002 0.0019
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0019 0.0016 0.0011
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0129 0.0339
Brugia malayi Inositol-1 0.004 0.0271 0.0717
Echinococcus multilocularis hemicentin 1 0.0019 0.002 0.0019
Schistosoma mansoni septate junction protein 0.0019 0.002 0.0004
Leishmania major GTP-binding protein, putative 0.0022 0.0056 0.0106
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0019 0.002 0.0051
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0569 0.064
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0051
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.019 0.0219
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0569 0.1469
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0129 0.0299
Loa Loa (eye worm) hypothetical protein 0.0072 0.0656 0.1734
Echinococcus multilocularis importin subunit beta 1 0.003 0.0152 0.0151
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.1029 0.1189
Schistosoma mansoni hypothetical protein 0.0357 0.4098 0.4729
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0019 0.0016 0.0043
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0774 0.2023
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.2767 0.3198
Loa Loa (eye worm) loechrig isoform VII 0.002 0.0026 0.0066
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0331 0.3777 1
Leishmania major hypothetical protein, conserved 0.002 0.0026 0.0026
Echinococcus multilocularis transcription factor btf3 0.0037 0.0238 0.0237
Echinococcus granulosus H:Cl exchange transporter 7 0.002 0.0026 0.0029
Schistosoma mansoni protein kinase subunit gamma 0.002 0.0026 0.0011
Brugia malayi Cytochrome P450 family protein 0.0059 0.0506 0.1338
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.002 0.0026 0.0011
Mycobacterium ulcerans hypothetical protein 0.002 0.0026 0.0037
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.002 0.0026 0.0029
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.002 0.0051
Entamoeba histolytica hypothetical protein 0.0115 0.1174 1
Schistosoma mansoni cell adhesion molecule 0.0019 0.002 0.0004
Schistosoma mansoni vesicular amine transporter 0.0019 0.0018 0.0003
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0321 0.3665 0.9703
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0019 0.0016 0.0043
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0019 0.002 0.0133
Schistosoma mansoni chloride channel protein 0.002 0.0026 0.0011
Onchocerca volvulus 0.002 0.0026 0.0173
Leishmania major trypanothione reductase 0.0049 0.0385 0.0979
Echinococcus multilocularis peroxidasin 0.0019 0.002 0.0019
Mycobacterium ulcerans cystathionine beta-synthase 0.002 0.0026 0.0037
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.0774 0.2159
Loa Loa (eye worm) hypothetical protein 0.0025 0.0088 0.023
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0018 0.0047
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0088 0.019
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0174 0.1883 0.4964
Echinococcus granulosus importin subunit beta 1 0.003 0.0152 0.0175
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0047
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0129 0.0339
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0056 1
Toxoplasma gondii hypothetical protein 0.0028 0.0128 0.0298
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0271 0.0313
Echinococcus multilocularis 0.0019 0.0016 0.0015
Schistosoma mansoni importin beta-1 0.003 0.0152 0.0157
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.002 0.0026 0.0026
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0019 0.0018 0.0003
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0056 0.0125
Brugia malayi Voltage gated chloride channel family protein 0.002 0.0026 0.0066
Echinococcus granulosus hemicentin 1 0.0019 0.002 0.0022
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0019 0.0016 0.0011
Echinococcus multilocularis neuroglian 0.0032 0.0175 0.0174
Mycobacterium ulcerans hypothetical protein 0.002 0.0026 0.0037
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0019 0.0016 0.0043
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0088 0.02
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.002 0.0026 0.0026
Schistosoma mansoni neuroglian 0.0019 0.002 0.0004
Brugia malayi CLC chloride channel protein 0.002 0.0026 0.0066
Entamoeba histolytica protein kinase, putative 0.0097 0.0955 0.8039
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0084 0.1027
Echinococcus multilocularis hemicentin 1 0.0019 0.002 0.0019
Echinococcus granulosus neuroglian 0.0019 0.002 0.0022
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0019 0.0016 0.0043
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.002 0.0051
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.002 0.0026 0.0026
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0331 0.3777 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0056 0.0055
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0385 0.1018
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0271 0.1925
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0271 0.8126
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0128 0.0298
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0066
Echinococcus granulosus peroxidasin 0.0019 0.002 0.0022
Schistosoma mansoni hypothetical protein 0.0033 0.019 0.0202
Echinococcus multilocularis protein patched 0.0044 0.0321 0.032
Trypanosoma cruzi chloride channel protein, putative 0.002 0.0026 0.0026
Echinococcus granulosus defective proboscis extension response 0.0019 0.0018 0.002
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.002 0.0026 0.0026
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0271 0.8126
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.0435 0.115
Loa Loa (eye worm) hypothetical protein 0.0025 0.0093 0.0245
Schistosoma mansoni hypothetical protein 0.0033 0.019 0.0202
Schistosoma mansoni microtubule-associated protein tau 0.0734 0.8649 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0019 0.0016 0.0043
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0019 0.002 0.0019
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0084 0.1027
Entamoeba histolytica protein kinase, putative 0.0097 0.0955 0.8039
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0331 0.3777 1
Loa Loa (eye worm) hypothetical protein 0.0247 0.2767 0.7324
Schistosoma mansoni chloride channel protein 0.002 0.0026 0.0011
Echinococcus granulosus expressed conserved protein 0.0097 0.0954 0.1102
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0019 0.002 0.0004
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0174 0.1883 0.4985
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.002 0.0051
Mycobacterium ulcerans hypothetical protein 0.002 0.0026 0.0037
Onchocerca volvulus 0.0025 0.0088 0.06
Entamoeba histolytica hypothetical protein 0.0097 0.0955 0.8039
Schistosoma mansoni roundabout 0.0019 0.002 0.0004
Schistosoma mansoni hypothetical protein 0.0043 0.0302 0.0331
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0385 0.0444
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0774 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0082 0.0774 0.0894
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0019 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0047
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.002 0.0051
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0088 0.02
Plasmodium falciparum thioredoxin reductase 0.0049 0.0385 0.1055
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.002 0.0026 0.0026

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.19 uM Inhibition of recombinant HIV integrase strand transfer activity ChEMBL. 16908139

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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