Detailed information for compound 41908

Basic information

Technical information
  • TDR Targets ID: 41908
  • Name: 5-amino-3-(4-imidazol-1-ylphenyl)-1H-pyridazi n-6-one
  • MW: 253.259 | Formula: C13H11N5O
  • H donors: 2 H acceptors: 4 LogP: 0.55 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1nnc(cc1N)c1ccc(cc1)n1cncc1
  • InChi: 1S/C13H11N5O/c14-11-7-12(16-17-13(11)19)9-1-3-10(4-2-9)18-6-5-15-8-18/h1-8H,(H2,14,16)(H,17,19)
  • InChiKey: LZSFWALTJLYIAU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-amino-3-[4-(1-imidazolyl)phenyl]-1H-pyridazin-6-one
  • 5-azanyl-3-(4-imidazol-1-ylphenyl)-1H-pyridazin-6-one
  • 4-amino-6-(4-imidazol-1-ylphenyl)-2H-pyridazin-3-one
  • 4-amino-6-[4-(1-imidazolyl)phenyl]-2H-pyridazin-3-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0177 0.227
Schistosoma mansoni lipoxygenase 0.002 0.0005 0.0005
Schistosoma mansoni cpg binding protein 0.003 0.0042 0.009
Entamoeba histolytica hypothetical protein 0.0039 0.0077 0.1004
Schistosoma mansoni glutamate receptor kainate 0.0144 0.0488 0.1125
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0177 0.1969
Schistosoma mansoni intermediate filament proteins 0.0082 0.0247 0.0566
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0041 0.0106
Echinococcus multilocularis glutamate receptor 2 0.0168 0.0583 0.0579
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0153 0.0799
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0076 0.0071
Brugia malayi 6-phosphofructokinase 0.0215 0.0768 0.2269
Echinococcus granulosus glutamate receptor 1 0.0043 0.0095 0.009
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0041 0.0088
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0066 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0041 0.0106
Echinococcus multilocularis lamin 0.0082 0.0247 0.0242
Onchocerca volvulus 0.003 0.0041 0.0093
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0079 0.0233 0.0228
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.0398 0.2079
Loa Loa (eye worm) hypothetical protein 0.0446 0.1671 0.4957
Echinococcus multilocularis geminin 0.0175 0.0612 0.0607
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0076 0.0049
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0186 0.0653 0.0648
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0099 0.1255
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0083 0.0251 0.0733
Toxoplasma gondii phosphofructokinase PFKII 0.0058 0.0153 0.1659
Schistosoma mansoni glutamate receptor kainate 0.0144 0.0488 0.1125
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0077 0.0072
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.0827 0.0822
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0076 0.0049
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0041 0.0088
Loa Loa (eye worm) hypothetical protein 0.0048 0.0112 0.0325
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0507 0.1912 0.1908
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0153 0.6
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0032 0.0375
Onchocerca volvulus Poor gastrulation protein homolog 0.0041 0.0087 0.0213
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0041 0.0036
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0112 0.1419
Loa Loa (eye worm) hypothetical protein 0.0083 0.0251 0.0739
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0041 0.0113
Schistosoma mansoni 6-phosphofructokinase 0.0215 0.0768 0.1773
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0058 0.0153 0.1991
Echinococcus granulosus beta-adrenergic receptor kinase 0.0039 0.0076 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0041 0.0106
Brugia malayi regulator of G-protein signaling egl-10 0.0039 0.0076 0.0211
Leishmania major trypanothione reductase 0.0048 0.0112 0.1083
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0225 0.0806 0.186
Brugia malayi nuclear receptor NHR-88 0.003 0.0041 0.0106
Echinococcus granulosus bloom syndrome protein 0.0065 0.018 0.0175
Brugia malayi intermediate filament protein 0.0082 0.0247 0.072
Brugia malayi Protein kinase domain containing protein 0.0023 0.0015 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0177 0.1969
Entamoeba histolytica hypothetical protein 0.0048 0.0112 0.1462
Toxoplasma gondii endonuclease IV APN 0.0083 0.0251 0.2749
Echinococcus granulosus atrial natriuretic peptide receptor 0.0042 0.009 0.0085
Mycobacterium tuberculosis Probable reductase 0.0109 0.035 0.1831
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0076 0.0071
Loa Loa (eye worm) excitatory amino acid transporter 0.0507 0.1912 0.5675
Loa Loa (eye worm) hypothetical protein 0.0048 0.0112 0.0325
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0421 0.0969
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0076 0.0071
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0259 0.0939 0.0935
Leishmania major cathepsin L-like protease 0.0064 0.0177 0.1812
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0039 0.0076 0.0217
Trichomonas vaginalis DNA helicase recq, putative 0.0065 0.018 0.0325
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0076 0.0071
Entamoeba histolytica hypothetical protein 0.0039 0.0077 0.1004
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0041 0.0106
Loa Loa (eye worm) RGC/RGC protein kinase 0.0042 0.009 0.0258
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0076 0.0169
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0096 0.0303 0.0298
Loa Loa (eye worm) hypothetical protein 0.0038 0.0075 0.0213
Loa Loa (eye worm) hypothetical protein 0.0048 0.0112 0.0325
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0048 0.0112 0.0325
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0039 0.0078 0.0073
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0078 0.0216
Echinococcus multilocularis Excitatory amino acid transporter 0.0507 0.1912 0.1908
Loa Loa (eye worm) RGC/RGC protein kinase 0.0042 0.009 0.0258
Schistosoma mansoni glutamate receptor AMPA 0.0083 0.0249 0.0571
Loa Loa (eye worm) glutamate receptor 2 0.0083 0.0249 0.0732
Loa Loa (eye worm) hypothetical protein 0.0027 0.0032 0.0085
Onchocerca volvulus 0.0048 0.0112 0.0279
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0041 0.0093
Schistosoma mansoni cell polarity protein 0.0023 0.0016 0.0031
Schistosoma mansoni survival motor neuron protein 0.0047 0.0109 0.0246
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0041 0.0036
Entamoeba histolytica recQ family helicase, putative 0.0044 0.0099 0.1289
Loa Loa (eye worm) hypothetical protein 0.0038 0.0075 0.0213
Entamoeba histolytica phosphofructokinase, putative 0.0215 0.0768 1
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0096 0.0303 0.0298
Echinococcus granulosus intermediate filament protein 0.0082 0.0247 0.0242
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0076 0.0211
Echinococcus granulosus GPCR family 3 C terminal 0.0041 0.0087 0.0082
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0041 0.0088
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0041 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0041 0.0106
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.0011 0.0119
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0153 0.1647
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.035 0.1831
Schistosoma mansoni z-protein (S1r protein) 0.0039 0.0076 0.0169
Entamoeba histolytica hypothetical protein 0.0042 0.009 0.1168
Chlamydia trachomatis neutral amino acid transporter 0.0225 0.0806 0.4214
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0066 0.0061
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0206 0.2656
Schistosoma mansoni hypothetical protein 0.0039 0.0077 0.0172
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0066 0.0147
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0112 0.0323
Trichomonas vaginalis set domain proteins, putative 0.1 0.3843 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0023 0.0015 0.0036
Schistosoma mansoni hypothetical protein 0.0048 0.0112 0.0253
Plasmodium falciparum cysteine repeat modular protein 1 0.0023 0.0015 0.0401
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0023 0.0016 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0041 0.0106
Schistosoma mansoni glutamate receptor kainate 0.0083 0.0249 0.0571
Echinococcus granulosus lamin dm0 0.0082 0.0247 0.0242
Echinococcus granulosus leukotriene A 4 hydrolase 0.0259 0.0939 0.0935
Echinococcus granulosus Regulator of G protein signaling 20 0.0039 0.0076 0.0071
Toxoplasma gondii 6-phosphofructokinase 0.0058 0.0153 0.1659
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0057 0.0712
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0023 0.0016 0.0033
Loa Loa (eye worm) abnormal epIthelia family member 0.0023 0.0016 0.0039
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0076 0.0211
Schistosoma mansoni thyroid hormone receptor 0.0296 0.1083 0.2501
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0005 0.0122
Brugia malayi hypothetical protein 0.0119 0.0391 0.1149
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0076 0.0169
Trypanosoma cruzi extracellular receptor, putative 0.0042 0.009 0.1133
Brugia malayi Kringle domain containing protein 0.0023 0.0015 0.0029
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0168 0.0583 0.0579
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0215 0.0768 0.4016
Schistosoma mansoni metabotropic glutamate receptor 0.0142 0.0481 0.1108
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0041 0.0113
Loa Loa (eye worm) hypothetical protein 0.0053 0.0134 0.039
Entamoeba histolytica hypothetical protein 0.0039 0.0076 0.099
Echinococcus granulosus tumor protein p63 0.0364 0.1352 0.1348
Brugia malayi EGF-like domain containing protein 0.0023 0.0016 0.0033
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0331 0.1221 0.1217
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0083 0.0251 0.3176
Loa Loa (eye worm) hypothetical protein 0.0048 0.0112 0.0325
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0024
Brugia malayi CXXC zinc finger family protein 0.003 0.0042 0.0109
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0215 0.0768 0.1488
Schistosoma mansoni thyroid hormone receptor 0.0296 0.1083 0.2501
Onchocerca volvulus 0.0082 0.0247 0.0631
Echinococcus multilocularis voltage dependent calcium channel subunit 0.117 0.4507 0.4505
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0507 0.1912 1
Schistosoma mansoni coup transcription factor 0.003 0.0041 0.0088
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0153 0.0252
Echinococcus multilocularis Protein lozenge 0.0056 0.0144 0.0139
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0206 0.0201
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0153 0.0296
Echinococcus multilocularis neutral amino acid transporter A 0.0507 0.1912 0.1908
Onchocerca volvulus 0.0446 0.1671 0.4341
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0153 0.0446
Brugia malayi hypothetical protein 0.023 0.0827 0.2445
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0041 0.0106
Loa Loa (eye worm) hypothetical protein 0.0043 0.0095 0.0273
Onchocerca volvulus 0.0048 0.0112 0.0279
Brugia malayi Cytochrome P450 family protein 0.0074 0.0217 0.0629
Loa Loa (eye worm) hypothetical protein 0.0048 0.0112 0.0325
Loa Loa (eye worm) hypothetical protein 0.0036 0.0066 0.0188
Loa Loa (eye worm) hypothetical protein 0.0039 0.0076 0.0217
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0039 0.0076 0.0071
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0066 0.0061
Loa Loa (eye worm) PXA domain-containing protein 0.0039 0.0076 0.0217
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0078 0.0827
Loa Loa (eye worm) hypothetical protein 0.0042 0.009 0.0258
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0225 0.0806 0.0801
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0076 0.0071
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0088 0.0083
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0039 0.0076 0.0071
Schistosoma mansoni hypothetical protein 0.0048 0.0112 0.0253
Loa Loa (eye worm) hypothetical protein 0.0039 0.0076 0.0217
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0022 0.0011 0.0015
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0225 0.0806 0.0801
Schistosoma mansoni lamin 0.0082 0.0247 0.0566
Brugia malayi Thioredoxin reductase 0.0048 0.0112 0.0317
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0039 0.0078 0.0073
Echinococcus multilocularis tyrosine kinase 0.0042 0.009 0.0085
Onchocerca volvulus 0.0048 0.0112 0.0279
Echinococcus multilocularis expressed protein 0.075 0.2862 0.2859
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0266 0.0967 0.0963
Brugia malayi steroid hormone receptor 0.003 0.0041 0.0106
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0039 0.0078 0.0073
Brugia malayi hypothetical protein 0.0039 0.0077 0.0214
Brugia malayi Pre-SET motif family protein 0.0127 0.0421 0.1237
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0081 0.0076
Plasmodium vivax SET domain protein, putative 0.0127 0.0421 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0041 0.0036
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0153 0.1546
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0066 0.047
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0112 0.0319
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0206 0.0471
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0149 0.0144
Echinococcus multilocularis neurogenic locus notch protein 0.0023 0.0016 0.0011
Treponema pallidum hypothetical protein 0.0048 0.0112 0.0217
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0057 0.0602
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0076 0.0169
Loa Loa (eye worm) hypothetical protein 0.0042 0.009 0.0258
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0078 0.0827
Echinococcus multilocularis glutamate receptor 4 0.0043 0.0095 0.009
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0112 0.1462
Echinococcus granulosus glutamate receptor 2 0.0168 0.0583 0.0579
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0112 0.2666
Schistosoma mansoni rab6-interacting 0.002 0.0005 0.0005
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.3213 0.3209
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0041 0.0106
Schistosoma mansoni tyrosine kinase 0.0042 0.009 0.0201
Echinococcus multilocularis neutral amino acid transporter A 0.0507 0.1912 0.1908
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0112 0.0106
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0066 0.0061
Onchocerca volvulus 0.0053 0.0134 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0041 0.0106
Mycobacterium ulcerans epimerase 0.0022 0.0011 0.0119
Loa Loa (eye worm) hypothetical protein 0.0048 0.0112 0.0325
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0164 0.1781
Echinococcus granulosus glutamate NMDA receptor subunit 0.0083 0.0249 0.0244
Loa Loa (eye worm) glutamate receptor 1 0.0126 0.0419 0.1236
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0123 0.1566
Onchocerca volvulus 0.0048 0.0112 0.0279
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0041 0.0106
Onchocerca volvulus 0.0082 0.0247 0.0631
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0041 0.0106
Brugia malayi phosphofructokinase 0.0215 0.0768 0.2269
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0061 0.0171
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0076 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0041 0.0106
Echinococcus granulosus glutamate receptor 2 0.0133 0.0445 0.044
Echinococcus multilocularis musashi 0.0082 0.0247 0.0242
Loa Loa (eye worm) hypothetical protein 0.0039 0.0076 0.0217
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0039
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0177 0.227
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0041 0.0093
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0507 0.1912 0.497
Schistosoma mansoni hypothetical protein 0.0266 0.0967 0.2234
Loa Loa (eye worm) hypothetical protein 0.004 0.0081 0.0231
Schistosoma mansoni rotamase 0.0035 0.0061 0.0134
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0041 0.0087 0.0243
Brugia malayi metabotropic glutamate receptor type 2 0.0142 0.0481 0.1415
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0177 0.1969
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0153 0.0252
Schistosoma mansoni rab6-interacting 0.002 0.0005 0.0005
Echinococcus multilocularis excitatory amino acid transporter 2 0.0507 0.1912 0.1908
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0177 0.227
Brugia malayi hypothetical protein 0.0039 0.0076 0.0211
Brugia malayi Glutamate receptor 1 precursor 0.0126 0.0419 0.123
Schistosoma mansoni polycystin 1-related 0.002 0.0005 0.0005
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0041 0.0036
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0251 0.0907 0.0902
Onchocerca volvulus 0.0127 0.0421 0.1084
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0041 0.0036
Loa Loa (eye worm) hypothetical protein 0.0041 0.0087 0.0249
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0153 0.0252
Echinococcus granulosus FTZ F1 alpha 0.003 0.0041 0.0036
Brugia malayi hypothetical protein 0.0263 0.0955 0.2824
Brugia malayi von Willebrand Factor 0.0048 0.0112 0.0319
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0041 0.0113
Loa Loa (eye worm) hypothetical protein 0.0082 0.0247 0.0726
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0006
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0153 0.1684
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0099 0.011
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0076 0.0071
Loa Loa (eye worm) hypothetical protein 0.003 0.0041 0.0113
Brugia malayi regulator of G-protein signaling rgs-7 0.0039 0.0076 0.0211
Loa Loa (eye worm) hypothetical protein 0.0127 0.0421 0.1243
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0048 0.0112 0.0107
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0039 0.0076 0.0217
Brugia malayi follicle stimulating hormone receptor 0.0466 0.1751 0.5192
Echinococcus multilocularis tumor protein p63 0.0364 0.1352 0.1348
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0153 0.0148
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0421 0.0969
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0061 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0177 0.1969
Schistosoma mansoni hypothetical protein 0.0423 0.1583 0.3661
Loa Loa (eye worm) hypothetical protein 0.0048 0.0112 0.0325
Loa Loa (eye worm) hypothetical protein 0.0039 0.0076 0.0217
Echinococcus granulosus glutamate receptor 4 0.0043 0.0095 0.009
Onchocerca volvulus 0.0047 0.0109 0.0271
Treponema pallidum ATP-dependent DNA helicase 0.002 0.0003 0.0005
Trichomonas vaginalis DNA helicase recq1, putative 0.0065 0.018 0.0325
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0153 0.044
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0058 0.0153 1
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0231 0.083 0.0825
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0039 0.0076 0.0211
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0149 0.0144
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0186 0.0653 0.0648
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0206 0.2144
Trichomonas vaginalis phosphofructokinase, putative 0.0215 0.0768 0.1878
Entamoeba histolytica phosphofructokinase, putative 0.0215 0.0768 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0057 0.0747
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0507 0.1912 0.1908
Echinococcus multilocularis pikachurin 0.0023 0.0016 0.0011
Schistosoma mansoni aldehyde dehydrogenase 0.0251 0.0907 0.2094
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0039
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0098 0.0276
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0186 0.0653 0.0648
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.1583 0.1579
Brugia malayi Excitatory amino acid transporter 0.0507 0.1912 0.5672
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0077 0.0072
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0153 0.0252
Loa Loa (eye worm) hypothetical protein 0.003 0.0041 0.0113
Echinococcus multilocularis Regulator of G protein signaling 20 0.0039 0.0076 0.0071
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0083 0.0251 0.0738
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0177 0.1969
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0083 0.0249 0.0244
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0121 0.04 0.0396
Loa Loa (eye worm) hypothetical protein 0.0048 0.0112 0.0325
Echinococcus granulosus nmda type glutamate receptor 0.0042 0.009 0.0085
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0099 0.0914
Loa Loa (eye worm) RGS-3 protein 0.0039 0.0076 0.0217
Brugia malayi Guanylyl cyclase protein 23 0.0042 0.009 0.0251
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0041 0.0093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0177 0.1969
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0048 0.0112 0.435
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0041 0.0087 0.0213
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0042 0.009 0.022
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0153 0.6001
Schistosoma mansoni laminin gamma-3 chain 0.0023 0.0016 0.0031
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0057 0.0712
Loa Loa (eye worm) hypothetical protein 0.0048 0.0112 0.0325
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0058 0.0153 0.1659
Schistosoma mansoni DNA helicase recq5 0.0039 0.0078 0.0173
Echinococcus granulosus nmda type glutamate receptor 0.0054 0.0139 0.0134
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0041 0.0088
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0041 0.0036
Loa Loa (eye worm) intermediate filament protein 0.0082 0.0247 0.0726
Loa Loa (eye worm) hypothetical protein 0.0042 0.009 0.0258
Plasmodium falciparum thrombospondin-related anonymous protein 0.0048 0.0112 0.435
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0177 0.1969
Brugia malayi Receptor family ligand binding region containing protein 0.0083 0.0251 0.0732
Loa Loa (eye worm) glutathione reductase 0.0048 0.0112 0.0323
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0096 0.0303 0.0298
Echinococcus multilocularis expressed protein 0.0035 0.0061 0.0056
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0153 0.196
Loa Loa (eye worm) phosphofructokinase 0.0215 0.0768 0.2274
Loa Loa (eye worm) hypothetical protein 0.0043 0.0095 0.0273
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0057 0.0476
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0048 0.0112 0.2666
Echinococcus granulosus cpg binding protein 0.0031 0.0048 0.0043
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0042 0.009 0.0085
Echinococcus granulosus Excitatory amino acid transporter 0.0507 0.1912 0.1908
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.0398 0.2079
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.0398 0.5108
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0076 0.0071
Mycobacterium ulcerans hypothetical protein 0.0022 0.0011 0.0119
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.035 0.1831
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0041 0.0036
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0088 0.0083
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0066 0.0061
Echinococcus multilocularis glutamate receptor 2 0.0126 0.0419 0.0414
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0153 0.9997
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0041 0.0106
Echinococcus granulosus excitatory amino acid transporter 2 0.0507 0.1912 0.1908
Echinococcus granulosus slit 2 protein 0.0023 0.0016 0.0011
Schistosoma mansoni glutamate receptor AMPA 0.0083 0.0249 0.0571
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0225 0.0806 0.186
Brugia malayi hypothetical protein 0.0042 0.009 0.0251
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0112 0.2649
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0042 0.009 0.0258
Schistosoma mansoni slit 0.0023 0.0016 0.0031
Brugia malayi hypothetical protein 0.0027 0.0032 0.0079
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0186 0.0653 0.0648
Loa Loa (eye worm) hypothetical protein 0.003 0.0041 0.0113
Schistosoma mansoni protein kinase 0.0042 0.009 0.0201
Entamoeba histolytica recQ family DNA helicase 0.002 0.0003 0.0039
Entamoeba histolytica phosphofructokinase, putative 0.0215 0.0768 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0041 0.0036
Loa Loa (eye worm) hypothetical protein 0.0046 0.0106 0.0305
Schistosoma mansoni hypothetical protein 0.0023 0.0015 0.0028
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0041 0.0113
Brugia malayi Zona pellucida-like domain containing protein 0.0048 0.0112 0.0319
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0109 0.0309
Schistosoma mansoni hypothetical protein 0.0047 0.0109 0.0246
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0048 0.0112 0.1209
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0206 0.0598
Brugia malayi Zona pellucida-like domain containing protein 0.0048 0.0112 0.0319
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0421 0.0969
Loa Loa (eye worm) hypothetical protein 0.0048 0.0112 0.0325
Echinococcus granulosus collagen alpha 1VII chain 0.0048 0.0112 0.0107
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0177 0.227
Echinococcus multilocularis 6 phosphofructokinase 0.0215 0.0768 0.0764
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0153 0.3632
Echinococcus granulosus Excitatory amino acid transporter 0.0507 0.1912 0.1908
Schistosoma mansoni DNA helicase recq1 0.0039 0.0078 0.0173
Schistosoma mansoni nuclear hormone receptor 0.003 0.0041 0.0088
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0112 0.0319
Brugia malayi hypothetical protein 0.0446 0.1671 0.4954
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0041 0.0036
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0066 0.0862
Echinococcus multilocularis voltage dependent calcium channel subunit 0.2572 1 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0066 0.0827
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0098 0.0282
Loa Loa (eye worm) hypothetical protein 0.0042 0.009 0.0258
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0032 0.0317
Schistosoma mansoni ATP-binding cassette transporter 0.0083 0.0249 0.0571
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.0907 1
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0076 0.0071
Onchocerca volvulus 0.0048 0.0112 0.0279
Echinococcus granulosus neutral amino acid transporter A 0.0507 0.1912 0.1908
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0041 0.0088
Loa Loa (eye worm) hypothetical protein 0.003 0.0041 0.0113
Brugia malayi A-kinase anchor protein 10, precursor 0.0039 0.0076 0.0211
Loa Loa (eye worm) cytochrome P450 family protein 0.0074 0.0217 0.0635
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0879 0.3368 1
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0066 0.0061
Schistosoma mansoni ap endonuclease 0.0058 0.0153 0.0347
Leishmania major cathepsin L-like protease 0.0064 0.0177 0.1812
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0153 0.0252
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0083 0.0251 1
Entamoeba histolytica hypothetical protein 0.0039 0.0076 0.099
Echinococcus granulosus geminin 0.0175 0.0612 0.0607
Echinococcus granulosus pikachurin 0.0023 0.0016 0.0011
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0039 0.0078 0.0222
Loa Loa (eye worm) hypothetical protein 0.0081 0.0241 0.0709
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0035 0.0064 0.0058
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0127 0.0421 0.4626
Echinococcus multilocularis nmda type glutamate receptor 0.0054 0.0139 0.0134
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0023 0.0015 0.0356
Echinococcus granulosus lamin 0.0082 0.0247 0.0242
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0177 0.1969
Brugia malayi Metabotropic glutamate receptor precursor. 0.0272 0.0991 0.2932
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0507 0.1912 0.4423
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0259 0.0939 0.2169
Loa Loa (eye worm) hypothetical protein 0.0039 0.0076 0.0217
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0083 0.0251 0.0738
Brugia malayi 6-phosphofructokinase 0.0215 0.0768 0.2269
Leishmania major cathepsin L-like protease 0.0064 0.0177 0.1812
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0116 0.0378 0.0373
Echinococcus multilocularis beta adrenergic receptor kinase 0.0039 0.0076 0.0071
Loa Loa (eye worm) hypothetical protein 0.0048 0.0112 0.0325
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0112 0.0319
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0168 0.0583 0.0579
Echinococcus multilocularis neutral amino acid transporter A 0.0507 0.1912 0.1908
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0215 0.0768 1
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0112 0.1462
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0035 0.0064 0.0058
Toxoplasma gondii kringle domain-containing protein 0.0023 0.0015 0.0133
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0186 0.0653 0.0648
Loa Loa (eye worm) hypothetical protein 0.0083 0.0251 0.0738
Toxoplasma gondii exonuclease III APE 0.0058 0.0153 0.1659
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0039 0.0078 0.0073
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0153 0.0799
Loa Loa (eye worm) RecQ helicase 0.0065 0.018 0.0528
Echinococcus multilocularis lamin dm0 0.0082 0.0247 0.0242
Chlamydia trachomatis glutamate symporter 0.0507 0.1912 1
Echinococcus multilocularis cpg binding protein 0.0031 0.0048 0.0043
Schistosoma mansoni aldehyde dehydrogenase 0.0251 0.0907 0.2094
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.035 0.1831
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0081 0.0076
Echinococcus granulosus survival motor neuron protein 1 0.023 0.0827 0.0822
Brugia malayi Cache domain containing protein 0.0518 0.1954 0.5795
Brugia malayi Pre-SET motif family protein 0.0879 0.3368 1
Treponema pallidum glutamate/aspartate transporter 0.0225 0.0806 0.1561
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0041 0.0088
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0206 0.237
Schistosoma mansoni hypothetical protein 0.0604 0.2292 0.5301
Brugia malayi glutathione reductase 0.0048 0.0112 0.0317
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0083 0.0251 0.5971
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0206 0.2684
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0036
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0039 0.0078 0.2948
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0153 0.196
Schistosoma mansoni tyrosine kinase 0.0042 0.009 0.0201
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0032 0.0375
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0032 0.0751
Loa Loa (eye worm) hypothetical protein 0.0042 0.009 0.0258
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.1337 0.5163 1
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0112 0.0319
Loa Loa (eye worm) hypothetical protein 0.003 0.0041 0.0113
Loa Loa (eye worm) hypothetical protein 0.0446 0.1671 0.4957
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0076 0.0169
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0042 0.009 0.0251
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0041 0.0088
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0251 0.0907 0.0902
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0058 0.0153 0.0252
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0177 0.1969
Brugia malayi hypothetical protein 0.0048 0.0112 0.0319
Plasmodium vivax glutathione reductase, putative 0.0048 0.0112 0.2649
Brugia malayi ecdysteroid receptor 0.003 0.0041 0.0106
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0153 0.0799
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0048 0.0112 0.0319
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0215 0.0768 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0066 0.0575
Leishmania major ATP-dependent phosphofructokinase 0.0215 0.0768 0.8445
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0177 0.1969
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0466 0.1751 0.5195
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0039 0.0076 0.0049
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.004 0.0081 0.0869
Schistosoma mansoni serine-rich repeat protein 0.0604 0.2292 0.5301
Brugia malayi PXA domain containing protein 0.0039 0.0076 0.0211
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0153 0.0252
Loa Loa (eye worm) hypothetical protein 0.0518 0.1954 0.5797
Echinococcus granulosus 6 phosphofructokinase 0.0215 0.0768 0.0764
Schistosoma mansoni hypothetical protein 0.002 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0048 0.0112 0.0325
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0153 0.6001
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0153 0.0252
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0048 0.0112 0.2666
Leishmania major hypothetical protein, conserved 0.0027 0.0032 0.0187
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0112 0.0319
Plasmodium falciparum thioredoxin reductase 0.0048 0.0112 0.4321
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0057 0.035
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0112 0.0319
Schistosoma mansoni ap endonuclease 0.0058 0.0153 0.0347
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0076 0.0169
Giardia lamblia Sgs1 DNA helicase, putative 0.0039 0.0078 0.1327
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0206 0.0201
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0041 0.0106
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.0247 0.0726
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0066 0.0061
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0066 0.0182
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0032 0.1076
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0076 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0066 0.0023
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0076 0.0169
Schistosoma mansoni blooms syndrome DNA helicase 0.0045 0.0103 0.0231
Loa Loa (eye worm) glutamate receptor 0.0272 0.0991 0.2937
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0076 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0041 0.0106
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0041 0.0036
Onchocerca volvulus 0.0048 0.0112 0.0279
Echinococcus granulosus tissue type plasminogen activator 0.0023 0.0015 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0041 0.0113
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0112 0.0319
Echinococcus multilocularis excitatory amino acid transporter 2 0.0507 0.1912 0.1908
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0066 0.0023
Toxoplasma gondii thioredoxin reductase 0.0048 0.0112 0.1201
Brugia malayi Receptor family ligand binding region containing protein 0.0042 0.009 0.0251
Echinococcus granulosus excitatory amino acid transporter 3 0.0507 0.1912 0.1908
Brugia malayi PXA domain containing protein 0.0039 0.0076 0.0211
Entamoeba histolytica hypothetical protein 0.0039 0.0077 0.1004
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0042 0.0115
Echinococcus granulosus glutamate receptor subunit protein glur 0.0079 0.0233 0.0228
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0186 0.0653 0.0648
Loa Loa (eye worm) 6-phosphofructokinase 0.0215 0.0768 0.2274
Treponema pallidum glutamate transporter 0.0225 0.0806 0.1561
Loa Loa (eye worm) hypothetical protein 0.023 0.0827 0.245
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0048 0.0112 0.0325
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0112 0.0106
Trichomonas vaginalis phosphofructokinase, putative 0.0215 0.0768 0.1878
Loa Loa (eye worm) hypothetical protein 0.0331 0.1221 0.362
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0041 0.0113
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0041 0.0036
Echinococcus multilocularis nmda type glutamate receptor 0.0042 0.009 0.0085
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0076 0.0071
Onchocerca volvulus 0.0042 0.009 0.022
Echinococcus multilocularis excitatory amino acid transporter 3 0.0507 0.1912 0.1908
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0032 0.1076
Echinococcus granulosus tyrosine kinase 0.0042 0.009 0.0085
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0015 0.0157
Onchocerca volvulus 0.1 0.3843 1
Trichomonas vaginalis rotamase, putative 0.0035 0.0061 0.0008
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0076 0.0071
Echinococcus multilocularis GPCR, family 3, C terminal 0.0041 0.0087 0.0082
Echinococcus granulosus voltage dependent calcium channel subunit 0.117 0.4507 0.4505
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0206 0.0604
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0006
Schistosoma mansoni hypothetical protein 0.0175 0.0612 0.1411
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0134 0.0304
Loa Loa (eye worm) hypothetical protein 0.0042 0.009 0.0258
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0076 0.0169
Schistosoma mansoni cpg binding protein 0.0031 0.0048 0.0105
Onchocerca volvulus 0.0048 0.0112 0.0279
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0041 0.0106
Entamoeba histolytica elongation factor-2 kinase, putative 0.0048 0.0112 0.1462
Trichomonas vaginalis phosphofructokinase, putative 0.0215 0.0768 0.1878
Echinococcus granulosus excitatory amino acid transporter 2 0.0507 0.1912 0.1908
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0153 0.1991
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0266 0.0967 0.0963
Schistosoma mansoni hypothetical protein 0.0041 0.0087 0.0194
Echinococcus granulosus neutral amino acid transporter 0.0507 0.1912 0.1908
Loa Loa (eye worm) glutamate receptor 0.01 0.0317 0.0932
Schistosoma mansoni cpg binding protein 0.0031 0.0048 0.0105
Brugia malayi laminin-like protein K08C7.3 precursor 0.0023 0.0016 0.0033
Echinococcus multilocularis thyroid hormone receptor alpha 0.0296 0.1083 0.1078
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0076 0.0071
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0112 0.0582
Plasmodium falciparum glutathione reductase 0.0048 0.0112 0.4321
Schistosoma mansoni 6-phosphofructokinase 0.0215 0.0768 0.1773
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0153 0.3632
Loa Loa (eye worm) hypothetical protein 0.0043 0.0095 0.0273
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0076 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0076 0.0049
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0041 0.0088
Loa Loa (eye worm) hypothetical protein 0.003 0.0041 0.0113
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0127 0.0421 0.0416
Echinococcus granulosus sodium:dicarboxylate symporter 0.0507 0.1912 0.1908
Schistosoma mansoni loxhd1 0.002 0.0005 0.0005
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0259 0.0939 0.2783
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0058 0.0153 0.0296
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0153 0.3631
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0041 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0076 0.0049
Entamoeba histolytica hypothetical protein 0.0039 0.0077 0.1004
Schistosoma mansoni lamin 0.0082 0.0247 0.0566
Brugia malayi hypothetical protein 0.0039 0.0076 0.0211
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0566 0.2141 0.4952
Brugia malayi laminin alpha chain 0.0023 0.0016 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0041 0.0113
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.023 0.0827 0.2443
Loa Loa (eye worm) hypothetical protein 0.0042 0.009 0.0258
Loa Loa (eye worm) hypothetical protein 0.0039 0.0078 0.0222
Loa Loa (eye worm) CUTiclin family member 0.0048 0.0112 0.0325
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.0398 0.2079
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.0247 0.072
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0048 0.0112 0.2666
Entamoeba histolytica hypothetical protein 0.0039 0.0076 0.099
Mycobacterium ulcerans endonuclease IV 0.0083 0.0251 0.2771
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0206 0.2656
Brugia malayi nuclear hormone receptor 0.003 0.0041 0.0106
Loa Loa (eye worm) doublecortin family protein 0.002 0.0005 0.0006
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0127 0.0421 0.0416
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0041 0.0036
Echinococcus granulosus receptor type guanylyl cyclase 0.0042 0.009 0.0085
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0061 0.0165
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0039 0.0076 0.0217
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.0011 0.0017
Schistosoma mansoni hypothetical protein 0.0035 0.0064 0.014
Echinococcus multilocularis Excitatory amino acid transporter 0.0507 0.1912 0.1908
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0155 0.1984
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0112 0.0319
Echinococcus granulosus dnaJ subfamily B 0.0423 0.1583 0.1579
Echinococcus multilocularis receptor type guanylyl cyclase 0.0042 0.009 0.0085
Echinococcus multilocularis NMDA receptor 0.0096 0.0303 0.0298
Echinococcus granulosus histone lysine methyltransferase setb 0.0127 0.0421 0.0416
Schistosoma mansoni metabotropic glutamate receptor 0.0231 0.083 0.1915
Onchocerca volvulus 0.0023 0.0015 0.0026
Loa Loa (eye worm) runx1 0.0056 0.0144 0.042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0177 0.1969
Mycobacterium ulcerans 6-phosphofructokinase 0.0215 0.0768 0.847
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0112 0.0319
Chlamydia trachomatis endonuclease IV 0.0083 0.0251 0.1314
Loa Loa (eye worm) hypothetical protein 0.0048 0.0112 0.0325
Loa Loa (eye worm) 6-phosphofructokinase 0.0215 0.0768 0.2274
Echinococcus granulosus metabotropic glutamate receptor 2 0.0231 0.083 0.0825
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0507 0.1912 1
Echinococcus granulosus neutral amino acid transporter A 0.0507 0.1912 0.1908
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.0907 1
Schistosoma mansoni lozenge 0.0056 0.0144 0.0327
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0251 0.0907 0.4742
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.0907 1
Treponema pallidum 76K protein 0.0048 0.0112 0.0217
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0153 0.0252
Plasmodium vivax thrombospondin-related anonymous protein 0.0048 0.0112 0.2666
Echinococcus granulosus expressed protein 0.075 0.2862 0.2859
Loa Loa (eye worm) hypothetical protein 0.003 0.0041 0.0113
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0153 0.0148
Onchocerca volvulus 0.003 0.0042 0.0095
Trichomonas vaginalis phosphofructokinase, putative 0.0215 0.0768 0.1878
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0251 0.0907 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.035 0.1831
Toxoplasma gondii microneme protein MIC2 0.0048 0.0112 0.1209
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0041 0.0036
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0011 0.0056
Schistosoma mansoni hypothetical protein 0.0175 0.0612 0.1411
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0039
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0215 0.0768 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0112 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0076 0.0049
Echinococcus multilocularis bloom syndrome protein 0.0065 0.018 0.0175
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0041 0.0088
Brugia malayi Bloom's syndrome protein homolog 0.0065 0.018 0.0521
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0083 0.0251 0.1314
Schistosoma mansoni lipoxygenase 0.0057 0.0149 0.0338
Schistosoma mansoni glutamate receptor NMDA 0.0125 0.0414 0.0952
Schistosoma mansoni glutamate receptor NMDA 0.0083 0.0249 0.0571
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0066 0.0827
Loa Loa (eye worm) hypothetical protein 0.0685 0.2608 0.7743
Loa Loa (eye worm) hypothetical protein 0.003 0.0041 0.0113
Echinococcus multilocularis glutamate receptor 2 0.0133 0.0445 0.044
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0078 0.0216
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0066 0.0147
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0077 0.0172
Echinococcus multilocularis slit 2 protein 0.0023 0.0016 0.0011
Echinococcus granulosus neurogenic locus notch protein 0.0023 0.0016 0.0011
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0076 0.0169
Echinococcus multilocularis regulator of G protein signaling 0.0039 0.0076 0.0071
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.006 0.0159 0.6256
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.1122 0.432 1
Toxoplasma gondii aldehyde dehydrogenase 0.0251 0.0907 1
Onchocerca volvulus 0.0042 0.009 0.022
Leishmania major extracellular receptor, putative 0.0042 0.009 0.0837
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0041 0.0036
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0048 0.0112 0.0145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0041 0.0113
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.019 0.0434
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0099 0.0942
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.035 0.1831
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0076 0.0049
Trypanosoma brucei trypanothione reductase 0.0048 0.0112 0.1085
Loa Loa (eye worm) hypothetical protein 0.0039 0.0076 0.0217
Echinococcus multilocularis tissue type plasminogen activator 0.0023 0.0015 0.001
Loa Loa (eye worm) RGC/RGC protein kinase 0.0042 0.009 0.0258
Loa Loa (eye worm) CUTiclin-Like family member 0.0048 0.0112 0.0325
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0039 0.0076 0.0169
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0048 0.0112 0.435
Brugia malayi Glutamate receptor 2 precursor 0.0126 0.0419 0.123
Echinococcus granulosus metabotropic glutamate receptor 5 0.0331 0.1221 0.1217
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0127 0.0421 0.0969
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0289 0.1057 0.244
Echinococcus granulosus expressed protein 0.0035 0.0061 0.0056
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.035 0.4481
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0076 0.0169
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0041 0.0084 0.2005

Activities

Activity type Activity value Assay description Source Reference
Dose (functional) = 0.3 mg kg-1 Evaluated for 50% increase of myocardial contractility in anesthetized dog, administered intravenously ChEMBL. 2864447
ED50 (functional) = 0.3 mg kg-1 Effective dose required to increase myocardial contractility in dog. ChEMBL. 2822926
IC50 (binding) = 22 uM Inhibitory concentration against cAMP PDE III enzyme in guinea pig ChEMBL. 2822926
IC50 (binding) = 22 uM Inhibitory concentration against cAMP PDE III enzyme in guinea pig ChEMBL. 2822926
IC50 (binding) = 88 uM Inhibitory concentration against cGMP PDE II enzyme in guinea pig ChEMBL. 2822926
IC50 (binding) = 88 uM Inhibitory concentration against cGMP PDE II enzyme in guinea pig ChEMBL. 2822926
IC50 (binding) = 110 uM Inhibition of PDE II enzyme in guinea pig ChEMBL. 2822926
IC50 (binding) = 110 uM Inhibition of PDE II enzyme in guinea pig ChEMBL. 2822926
IC50 (binding) > 500 uM Inhibitory concentration against cAMP PDE I enzyme in guinea pig ChEMBL. 2822926
IC50 (binding) > 500 uM Inhibitory concentration against cGMP PDE I enzyme in guinea pig ChEMBL. 2822926
IC50 (binding) > 500 uM Inhibitory concentration against cAMP PDE I enzyme in guinea pig ChEMBL. 2822926
IC50 (binding) > 500 uM Inhibitory concentration against cGMP PDE I enzyme in guinea pig ChEMBL. 2822926
Inhibition (binding) = 6 % Inhibition of cAMP PDE I enzyme in guinea pig at 1E-5M concentration ChEMBL. 2822926
Inhibition (binding) = 6 % Inhibition of cAMP PDE I enzyme in guinea pig at 1E-5M concentration ChEMBL. 2822926
Inhibition (binding) = 7 % Inhibition of cGMP PDE I enzyme in guinea pig at 1E-5M concentration ChEMBL. 2822926
Inhibition (binding) = 7 % Inhibition of cGMP PDE I enzyme in guinea pig at 1E-5M concentration ChEMBL. 2822926
Inhibition (binding) = 10 % Inhibition of cGMP PDE II enzyme in guinea pig at 1E-5M concentration ChEMBL. 2822926
Inhibition (binding) = 10 % Inhibition of cGMP PDE II enzyme in guinea pig at 1E-5M concentration ChEMBL. 2822926
Inhibition (binding) = 13 % Inhibition of cAMP PDE II enzyme in guinea pig at 1E-5M concentration ChEMBL. 2822926
Inhibition (binding) = 13 % Inhibition of cAMP PDE II enzyme in guinea pig at 1E-5M concentration ChEMBL. 2822926
Inhibition (binding) = 20 % Inhibition of cAMP PDE I enzyme in guinea pig at 1E-4M concentration. ChEMBL. 2822926
Inhibition (binding) = 20 % Inhibition of cAMP PDE I enzyme in guinea pig at 1E-4M concentration. ChEMBL. 2822926
Inhibition (binding) = 28 % Inhibition of cGMP PDE I enzyme in guinea pig at 1E-4M concentration ChEMBL. 2822926
Inhibition (binding) = 28 % Inhibition of cGMP PDE I enzyme in guinea pig at 1E-4M concentration ChEMBL. 2822926
Inhibition (binding) = 41 % Inhibition of cAMP PDE III enzyme in guinea pig at 1E-5M concentration ChEMBL. 2822926
Inhibition (binding) = 41 % Inhibition of cAMP PDE III enzyme in guinea pig at 1E-5M concentration ChEMBL. 2822926
Inhibition (binding) = 44 % Inhibition of cAMP PDE II enzyme in guinea pig at 1E-4M concentration. ChEMBL. 2822926
Inhibition (binding) = 44 % Inhibition of cAMP PDE II enzyme in guinea pig at 1E-4M concentration. ChEMBL. 2822926
Inhibition (binding) = 51 % Inhibition of cGMP PDE II enzyme in guinea pig at 1E-4M concentration ChEMBL. 2822926
Inhibition (binding) = 51 % Inhibition of cGMP PDE II enzyme in guinea pig at 1E-4M concentration ChEMBL. 2822926
Inhibition (binding) = 64 % Inhibition of cAMP PDE III enzyme in guinea pig at 1E-4M concentration. ChEMBL. 2822926
Inhibition (binding) = 64 % Inhibition of cAMP PDE III enzyme in guinea pig at 1E-4M concentration. ChEMBL. 2822926
Ratio (binding) < 44 Ratio of IC50 values for PDE III and PDE I. ChEMBL. 2822926
Ratio (binding) = 200 Ratio of IC50 values for PDE III and PDE II. ChEMBL. 2822926

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.