Detailed information for compound 430103

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 441.479 | Formula: C26H23N3O4
  • H donors: 3 H acceptors: 3 LogP: 3.7 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=C(C(N1)c1ccc(cc1)OCCn1c2ccccc2c2c1cccc2)C(=O)O)C
  • InChi: 1S/C26H23N3O4/c1-16-23(25(30)31)24(28-26(32)27-16)17-10-12-18(13-11-17)33-15-14-29-21-8-4-2-6-19(21)20-7-3-5-9-22(20)29/h2-13,24H,14-15H2,1H3,(H,30,31)(H2,27,28,32)
  • InChiKey: MWYILUFIXQCFSK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens peroxisome proliferator-activated receptor gamma Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus ecdysone induced protein 78C peroxisome proliferator-activated receptor gamma 477 aa 447 aa 28.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ATP binding cassette sub family G 0.002 0.0221 0.0221
Trichomonas vaginalis tubulin, putative 0.0148 0.2882 0.2801
Echinococcus granulosus tubulin alpha chain 0.0362 0.7298 0.7298
Echinococcus granulosus ATP binding cassette sub family G 0.002 0.0221 0.0221
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.062 0.062
Echinococcus multilocularis beta tubulin 0.0492 1 1
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0243 0.0243
Brugia malayi Tubulin beta chain 0.0148 0.2882 0.2882
Leishmania major beta tubulin 0.0492 1 1
Plasmodium vivax tubulin gamma chain, putative 0.0262 0.524 0.5132
Schistosoma mansoni lipoxygenase 0.0163 0.3194 0.3194
Brugia malayi multidrug resistance protein 3 0.0021 0.0243 0.0243
Schistosoma mansoni tubulin subunit epsilon 0.0262 0.524 0.524
Brugia malayi Protein kinase domain containing protein 0.0086 0.1592 0.1592
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.1084 0.1084
Loa Loa (eye worm) hypothetical protein 0.002 0.0233 0.0233
Loa Loa (eye worm) tubulin alpha 2 0.0099 0.1868 0.1868
Leishmania major beta tubulin 0.0492 1 1
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0086 0.1592 0.1592
Schistosoma mansoni tubulin subunit delta 0.0114 0.2168 0.2168
Trypanosoma cruzi beta tubulin, putative 0.0492 1 1
Trypanosoma brucei beta tubulin 0.0492 1 1
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0243 0.0131
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0251 0.5001 0.4943
Brugia malayi ABC transporter family protein 0.0017 0.0159 0.0159
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0251 0.5001 1
Leishmania major beta tubulin 0.0492 1 1
Schistosoma mansoni tubulin subunit alpha 0.0362 0.7298 0.7298
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0137 0.0137
Echinococcus multilocularis Tubulin alpha 1 chain 0.0362 0.7298 0.7298
Echinococcus multilocularis tubulin alpha chain 0.0362 0.7298 0.7298
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0243 0.0131
Onchocerca volvulus 0.0021 0.0243 0.0485
Entamoeba histolytica tubulin family protein 0.0492 1 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.1592 0.1592
Echinococcus multilocularis tubulin gamma 1 chain 0.0262 0.524 0.524
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.062 0.062
Giardia lamblia Beta tubulin 0.0492 1 1
Toxoplasma gondii beta tubulin 0.0492 1 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0251 0.5001 0.4888
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.0243 0.0131
Leishmania major delta tubulin, putative 0.0114 0.2168 0.1991
Echinococcus multilocularis Tubulin beta 2C chain 0.0492 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0362 0.7298 0.7267
Echinococcus multilocularis tubulin subunit TubB 0.0362 0.7298 0.7298
Trichomonas vaginalis tubulin epsilon chain, putative 0.0114 0.2168 0.2078
Leishmania major beta tubulin 0.0492 1 1
Schistosoma mansoni alpha tubulin 0.0362 0.7298 0.7298
Toxoplasma gondii alpha tubulin TUBA1 0.0362 0.7298 0.7237
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0842 0.0842
Leishmania major beta tubulin 0.0492 1 1
Brugia malayi TAR-binding protein 0.0062 0.1084 0.1084
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0243 0.0243
Trichomonas vaginalis tubulin beta chain, putative 0.0148 0.2882 0.2801
Echinococcus multilocularis Tubulin beta 2C chain 0.0492 1 1
Echinococcus granulosus Ankyrin 0.0086 0.1592 0.1592
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0243 0.0243
Trypanosoma brucei beta tubulin 0.0492 1 1
Trypanosoma brucei zeta tubulin 0.0114 0.2168 0.1991
Entamoeba histolytica P-glycoprotein-1 0.0021 0.0243 0.0022
Entamoeba histolytica tubulin family protein 0.0492 1 1
Schistosoma mansoni netrin receptor unc5 0.0086 0.1592 0.1592
Plasmodium falciparum tubulin delta chain, putative 0.0114 0.2168 0.1991
Loa Loa (eye worm) tubulin alpha 2 0.0248 0.494 0.494
Echinococcus granulosus tubulin beta 4A class IVa 0.0492 1 1
Schistosoma mansoni tubulin subunit beta 0.0492 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0243 0.0243
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0243 0.0243
Schistosoma mansoni ankyrin 23/unc44 0.0086 0.1592 0.1592
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0137 0.0137
Echinococcus granulosus tubulin alpha chain 0.0362 0.7298 0.7298
Entamoeba histolytica tubulin alpha chain, putative 0.0362 0.7298 0.7237
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0086 0.1592 0.1592
Trichomonas vaginalis tubulin, putative 0.0148 0.2882 0.2801
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0243 0.0131
Schistosoma mansoni rab6-interacting 0.0039 0.062 0.062
Loa Loa (eye worm) hypothetical protein 0.0248 0.494 0.494
Schistosoma mansoni hypothetical protein 0.0169 0.3318 0.3318
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0243 0.0243
Echinococcus granulosus tubulin alpha 1C chain 0.0362 0.7298 0.7298
Schistosoma mansoni multidrug resistance protein 0.0021 0.0243 0.0243
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0248 0.494 0.4882
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0243 0.0243
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0243 0.0243
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0243 0.0131
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0243 0.0131
Onchocerca volvulus 0.0039 0.062 0.1239
Leishmania major beta tubulin 0.0492 1 1
Leishmania major alpha tubulin 0.0362 0.7298 0.7237
Giardia lamblia Alpha-tubulin 0.0362 0.7298 0.7239
Loa Loa (eye worm) tubulin alpha chain 0.0362 0.7298 0.7298
Loa Loa (eye worm) tubulin alpha chain 0.0362 0.7298 0.7298
Loa Loa (eye worm) tubulin alpha-2 chain 0.0362 0.7298 0.7298
Echinococcus multilocularis RUN 0.0039 0.062 0.062
Echinococcus granulosus Tubulin beta 2C chain 0.0492 1 1
Echinococcus granulosus GPCR family 2 0.0016 0.0137 0.0137
Echinococcus granulosus RUN 0.0039 0.062 0.062
Echinococcus multilocularis ATP binding cassette sub family G 0.002 0.0221 0.0221
Trichomonas vaginalis tubulin gamma chain, putative 0.0492 1 1
Schistosoma mansoni tubulin subunit beta 0.0492 1 1
Echinococcus granulosus tubulin beta 1 chain 0.0492 1 1
Echinococcus multilocularis geminin 0.0169 0.3318 0.3318
Schistosoma mansoni tubulin subunit alpha 0.0114 0.2168 0.2168
Echinococcus granulosus tubulin alpha chain 0.0362 0.7298 0.7298
Onchocerca volvulus Netrin receptor homolog 0.0086 0.1592 0.3183
Loa Loa (eye worm) beta-tubulin 0.0492 1 1
Brugia malayi Tubulin beta chain 0.0114 0.2168 0.2168
Echinococcus multilocularis tubulin alpha 1C chain 0.0362 0.7298 0.7298
Echinococcus granulosus Tubulin alpha 1 chain 0.0362 0.7298 0.7298
Mycobacterium ulcerans cell division protein FtsZ 0.0114 0.2168 0.4073
Trichomonas vaginalis tubulin alpha chain, putative 0.0148 0.2882 0.2801
Echinococcus multilocularis Tubulin alpha 1 chain 0.0362 0.7298 0.7298
Entamoeba histolytica P-glycoprotein 5, putative 0.0021 0.0243 0.0022
Leishmania major alpha tubulin 0.0362 0.7298 0.7237
Entamoeba histolytica P-glycoprotein-5 0.0021 0.0243 0.0022
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.2282 0.2282
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0842 0.0842
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0251 0.5001 0.4943
Trichomonas vaginalis tubulin alpha chain, putative 0.0492 1 1
Leishmania major epsilon tubulin, putative 0.0262 0.524 0.5132
Echinococcus granulosus geminin 0.0169 0.3318 0.3318
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.0243 0.0131
Echinococcus granulosus Tubulin beta 2C chain 0.0492 1 1
Echinococcus multilocularis peroxisome assembly protein 26 0.0362 0.7298 0.7298
Schistosoma mansoni multidrug resistance protein 0.0021 0.0243 0.0243
Trypanosoma brucei alpha tubulin 0.0362 0.7298 0.7237
Echinococcus multilocularis tubulin epsilon chain 0.0262 0.524 0.524
Trichomonas vaginalis abcb9, putative 0.0021 0.0243 0.0131
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0251 0.5001 0.4888
Echinococcus granulosus tubulin alpha 3 chain 0.0362 0.7298 0.7298
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0243 0.0131
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0243 0.0131
Leishmania major beta tubulin 0.0492 1 1
Brugia malayi N-terminal motif family protein 0.0175 0.3441 0.3441
Echinococcus granulosus tubulin alpha 3 chain 0.0362 0.7298 0.7298
Loa Loa (eye worm) hypothetical protein 0.0034 0.0516 0.0516
Schistosoma mansoni hypothetical protein 0.0169 0.3318 0.3318
Schistosoma mansoni tubulin subunit beta 0.0492 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0492 1 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0114 0.2168 0.1991
Giardia lamblia Delta tubulin 0.0114 0.2168 0.1999
Brugia malayi hypothetical protein 0.0039 0.062 0.062
Plasmodium vivax tubulin beta chain, putative 0.0492 1 1
Loa Loa (eye worm) RNA binding protein 0.0062 0.1084 0.1084
Echinococcus multilocularis tubulin alpha chain 0.0362 0.7298 0.7298
Brugia malayi tubulin alpha-2 chain 0.0362 0.7298 0.7298
Leishmania major p-glycoprotein 0.0021 0.0243 0.0022
Loa Loa (eye worm) hypothetical protein 0.0175 0.3441 0.3441
Loa Loa (eye worm) hypothetical protein 0.0039 0.062 0.062
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0251 0.5001 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.2282 0.2282
Trypanosoma brucei tubulin delta chain 0.0114 0.2168 0.1991
Echinococcus multilocularis netrin receptor unc 5 0.0086 0.1592 0.1592
Schistosoma mansoni alpha tubulin 0.0362 0.7298 0.7298
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0251 0.5001 0.4893
Leishmania major beta tubulin 0.0492 1 1
Echinococcus multilocularis tubulin subunit beta 0.0492 1 1
Toxoplasma gondii alpha-tubulin I, putative 0.0362 0.7298 0.7237
Leishmania major beta tubulin 0.0492 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0114 0.2168 0.2078
Plasmodium falciparum alpha tubulin 1 0.0362 0.7298 0.7237
Echinococcus multilocularis tar DNA binding protein 0.0062 0.1084 0.1084
Echinococcus granulosus alpha tubulin 0.0362 0.7298 0.7298
Brugia malayi MH2 domain containing protein 0.0119 0.2282 0.2282
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.062 0.062
Mycobacterium leprae cell division protein FtsZ 0.0114 0.2168 0.5
Loa Loa (eye worm) hypothetical protein 0.0213 0.4226 0.4226
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0213 0.4226 0.4159
Trypanosoma brucei tubulin gamma chain 0.0262 0.524 0.5132
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0114 0.2168 0.2078
Schistosoma mansoni hypothetical protein 0.0016 0.0137 0.0137
Trichomonas vaginalis tubulin beta chain, putative 0.0492 1 1
Leishmania major beta tubulin 0.0492 1 1
Entamoeba histolytica tubulin gamma chain 0.0262 0.524 0.5132
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0243 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.2168 0.2078
Leishmania major gamma-tubulin 0.0262 0.524 0.5132
Plasmodium falciparum tubulin gamma chain 0.0262 0.524 0.5132
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0243 0.0243
Trypanosoma brucei beta tubulin 0.0262 0.524 0.5132
Echinococcus multilocularis tubulin alpha 3 chain 0.0362 0.7298 0.7298
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0131 0.2529 0.2529
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0243 0.0131
Trypanosoma brucei epsilon tubulin 0.0262 0.524 0.5132
Brugia malayi alpha-tubulin 0.0362 0.7298 0.7298
Trichomonas vaginalis tubulin gamma chain, putative 0.0262 0.524 0.5185
Brugia malayi Doublecortin family protein 0.0039 0.062 0.062
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0086 0.1592 0.1592
Giardia lamblia Gamma tubulin 0.0262 0.524 0.5137
Schistosoma mansoni tubulin subunit beta 0.0492 1 1
Loa Loa (eye worm) tubulin alpha-3 chain 0.0213 0.4226 0.4226
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0131 0.2529 0.2529
Brugia malayi Uncoordinated protein 44 0.0086 0.1592 0.1592
Entamoeba histolytica P-glycoprotein-2 0.0021 0.0243 0.0022
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0243 0.0131
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0243 0.0131
Leishmania major alpha tubulin 0.0362 0.7298 0.7237
Echinococcus multilocularis beta tubulin 0.0492 1 1
Leishmania major beta tubulin 0.0492 1 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0362 0.7298 0.7298
Schistosoma mansoni rab6-interacting 0.0039 0.062 0.062
Echinococcus multilocularis ATP binding cassette sub family G 0.002 0.0221 0.0221
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0262 0.524 0.5132
Trichomonas vaginalis tubulin beta chain, putative 0.0362 0.7298 0.7267
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0251 0.5001 0.4943
Schistosoma mansoni tubulin subunit alpha 0.0362 0.7298 0.7298
Trichomonas vaginalis tubulin epsilon chain, putative 0.0492 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0492 1 1
Echinococcus granulosus tubulin subunit TubB 0.0362 0.7298 0.7298
Trichomonas vaginalis abcb9, putative 0.0021 0.0243 0.0131
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0362 0.7298 0.7267
Brugia malayi Tubulin gamma chain 0.0262 0.524 0.524
Schistosoma mansoni multidrug resistance protein 0.0021 0.0243 0.0243
Plasmodium vivax multidrug resistance protein 1, putative 0.0021 0.0243 0.0022
Brugia malayi hypothetical protein 0.0039 0.062 0.062
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0243 0.0243
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0251 0.5001 0.4943
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0243 0.0131
Trypanosoma brucei alpha tubulin 0.0362 0.7298 0.7237
Echinococcus multilocularis Ankyrin 0.0086 0.1592 0.1592
Schistosoma mansoni tumor necrosis factor receptor related 0.0131 0.2529 0.2529
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0086 0.1592 0.1592
Toxoplasma gondii beta-tubulin, putative 0.0492 1 1
Entamoeba histolytica tubulin alpha-1 chain 0.0362 0.7298 0.7237
Echinococcus granulosus tubulin alpha chain 0.0362 0.7298 0.7298
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1084 0.1084
Plasmodium vivax tubulin epsilon chain, putative 0.0262 0.524 0.5132
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0137 0.0137
Echinococcus granulosus tubulin alpha 1C chain 0.0362 0.7298 0.7298
Leishmania major alpha tubulin 0.0362 0.7298 0.7237
Echinococcus multilocularis tubulin delta chain 0.0114 0.2168 0.2168
Trypanosoma brucei beta tubulin 0.0492 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1084 0.1084
Schistosoma mansoni hypothetical protein 0.0039 0.062 0.062
Schistosoma mansoni tubulin subunit beta 0.0114 0.2168 0.2168
Echinococcus multilocularis tubulin alpha 3 chain 0.0362 0.7298 0.7298
Echinococcus granulosus peroxisome assembly protein 26 0.0362 0.7298 0.7298
Echinococcus multilocularis Tubulin alpha 1 chain 0.0362 0.7298 0.7298
Brugia malayi ABC transporter family protein 0.0021 0.0243 0.0243
Trypanosoma brucei alpha tubulin 0.0362 0.7298 0.7237
Giardia lamblia Epsilon tubulin 0.0114 0.2168 0.1999
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0021 0.0243 0.5
Trypanosoma brucei beta tubulin 0.0492 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0243 0.0243
Echinococcus granulosus Tubulin beta 2C chain 0.0492 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0492 1 1
Treponema pallidum cell division protein FtsZ 0.0114 0.2168 0.5
Echinococcus multilocularis hypothetical protein 0.0362 0.7298 0.7298
Trichomonas vaginalis tubulin epsilon chain, putative 0.0492 1 1
Plasmodium vivax tubulin alpha chain, putative 0.0362 0.7298 0.7237
Trichomonas vaginalis tubulin alpha chain, putative 0.0148 0.2882 0.2801
Leishmania major alpha tubulin 0.0362 0.7298 0.7237
Echinococcus granulosus tar DNA binding protein 0.0062 0.1084 0.1084
Echinococcus granulosus tubulin alpha chain 0.0362 0.7298 0.7298
Giardia lamblia Alpha-tubulin 0.0362 0.7298 0.7239
Schistosoma mansoni tubulin subunit beta 0.0492 1 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0842 0.0842
Echinococcus granulosus ATP binding cassette sub family G 0.002 0.0221 0.0221
Echinococcus multilocularis tubulin alpha chain 0.0362 0.7298 0.7298
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.062 0.062
Brugia malayi Tubulin alpha chain 0.0114 0.2168 0.2168
Trypanosoma brucei alpha tubulin 0.0362 0.7298 0.7237
Onchocerca volvulus 0.0251 0.5001 1
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.062 0.0408
Trichomonas vaginalis tubulin gamma chain, putative 0.0262 0.524 0.5185
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0137 0.0137
Trypanosoma cruzi zeta tubulin, putative 0.0114 0.2168 0.1991
Leishmania major zeta tubulin, putative 0.0114 0.2168 0.1991
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0251 0.5001 0.5001
Trichomonas vaginalis tubulin beta chain, putative 0.0362 0.7298 0.7267
Schistosoma mansoni smdr2 0.0021 0.0243 0.0243
Loa Loa (eye worm) tubulin gamma chain 0.0262 0.524 0.524
Plasmodium vivax tubulin alpha chain, putative 0.0362 0.7298 0.7237
Schistosoma mansoni hypothetical protein 0.0016 0.0137 0.0137
Plasmodium falciparum multidrug resistance protein 1 0.0021 0.0243 0.0022
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0114 0.2168 0.5
Schistosoma mansoni tubulin subunit gamma 0.0262 0.524 0.524
Loa Loa (eye worm) TAR-binding protein 0.0062 0.1084 0.1084
Trypanosoma cruzi epsilon tubulin, putative 0.0262 0.524 0.5132
Trichomonas vaginalis tubulin alpha chain, putative 0.0262 0.524 0.5185
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0131 0.2529 0.2529
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0131 0.2529 0.2529
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0243 0.0131
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1084 0.1084
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.002 0.0233 0.0233
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0234 0.465 0.465
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.062 0.062
Trypanosoma cruzi tubulin delta chain 0.0114 0.2168 0.1991
Leishmania major beta tubulin 0.0492 1 1
Brugia malayi RNA binding protein 0.0062 0.1084 0.1084
Loa Loa (eye worm) hypothetical protein 0.0362 0.7298 0.7298
Schistosoma mansoni ABC transporter 0.0017 0.0159 0.0159
Echinococcus granulosus multidrug resistance protein 1 0.0015 0.0114 0.0114
Loa Loa (eye worm) BEN-1 protein 0.0492 1 1
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0243 0.0131
Trypanosoma brucei epsilon tubulin 0.0262 0.524 0.5132
Echinococcus granulosus tubulin alpha 0.0262 0.524 0.524
Onchocerca volvulus 0.0148 0.2882 0.5764
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0243 0.0022
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0251 0.5001 0.5001
Plasmodium falciparum tubulin epsilon chain, putative 0.0262 0.524 0.5132
Schistosoma mansoni hypothetical protein 0.0034 0.0516 0.0516
Echinococcus granulosus tubulin delta chain 0.0114 0.2168 0.2168
Trichomonas vaginalis tubulin beta chain, putative 0.0362 0.7298 0.7267
Trypanosoma cruzi tubulin delta chain 0.0114 0.2168 0.1991
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0243 0.0131
Trichomonas vaginalis tubulin, putative 0.0492 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0137 0.0137
Schistosoma mansoni tubulin subunit alpha 0.0362 0.7298 0.7298
Schistosoma mansoni loxhd1 0.0039 0.062 0.062
Trichomonas vaginalis tubulin beta chain, putative 0.0362 0.7298 0.7267
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0251 0.5001 0.4943
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.062 0.0408
Schistosoma mansoni hypothetical protein 0.0016 0.0137 0.0137
Echinococcus multilocularis tubulin alpha 1C chain 0.0362 0.7298 0.7298
Schistosoma mansoni polycystin 1-related 0.0039 0.062 0.062
Echinococcus multilocularis ATP binding cassette sub family G 0.002 0.0221 0.0221
Trypanosoma cruzi alpha tubulin, putative 0.0362 0.7298 0.7237
Echinococcus granulosus tubulin epsilon chain 0.0262 0.524 0.524
Echinococcus granulosus tubulin gamma 1 chain 0.0262 0.524 0.524
Brugia malayi Tubulin alpha-2 chain 0.0362 0.7298 0.7298
Echinococcus multilocularis multidrug resistance protein 1 0.0015 0.0114 0.0114
Brugia malayi Immunoglobulin I-set domain containing protein 0.0086 0.1592 0.1592
Entamoeba histolytica P-glyco protein 6, putative 0.0021 0.0243 0.0022
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0243 0.0131
Loa Loa (eye worm) tubulin beta-4 chain 0.0492 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0243 0.0131
Trypanosoma cruzi tubulin gamma chain 0.0262 0.524 0.5132
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0243 0.0131
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0021 0.0243 0.0243
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0243 0.0131
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0243 0.0131
Loa Loa (eye worm) hypothetical protein 0.0039 0.062 0.062
Loa Loa (eye worm) ABC transporter 0.0017 0.0159 0.0159
Giardia lamblia Beta tubulin 0.0492 1 1
Leishmania major alpha tubulin 0.0362 0.7298 0.7237
Leishmania major beta tubulin 0.0492 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0362 0.7298 0.7267
Schistosoma mansoni hypothetical protein 0.0016 0.015 0.015
Loa Loa (eye worm) BEN-1 protein 0.0492 1 1
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.002 0.0221 0.0221
Entamoeba histolytica P-glycoprotein-2, putative 0.0021 0.0243 0.0022
Echinococcus multilocularis tubulin alpha chain 0.0362 0.7298 0.7298
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.062 0.062
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0492 1 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0137 0.0137
Brugia malayi Death domain containing protein 0.0086 0.1592 0.1592
Leishmania major alpha tubulin 0.0362 0.7298 0.7237
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0243 0.0131
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0243 0.0243
Brugia malayi tubulin alpha chain - mouse 0.0362 0.7298 0.7298
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0516 0.0516
Echinococcus granulosus tubulin subunit beta 0.0492 1 1
Echinococcus multilocularis tubulin alpha chain 0.0362 0.7298 0.7298
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0137 0.0137
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0243 0.0131
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1084 0.1084
Trypanosoma brucei alpha tubulin, putative 0.0148 0.2882 0.2722
Echinococcus granulosus beta tubulin 0.0492 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0243 0.0243
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0137 0.0137
Echinococcus granulosus beta tubulin 0.0492 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0148 0.2882 0.2801
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0243 0.0243
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0021 0.0243 0.0022
Trichomonas vaginalis tubulin, putative 0.0114 0.2168 0.2078
Echinococcus multilocularis tubulin alpha 0.0262 0.524 0.524
Brugia malayi Tubulin alpha chain 0.0362 0.7298 0.7298
Trichomonas vaginalis taga, putative 0.0021 0.0243 0.0131
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0842 0.0842
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0021 0.0243 0.0192
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1084 0.1084
Schistosoma mansoni hypothetical protein 0.0016 0.0137 0.0137
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0021 0.0243 0.0022
Brugia malayi beta-tubulin, identical 0.0492 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.1084 0.1084
Echinococcus multilocularis tubulin beta 1 chain 0.0492 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0243 0.0243
Brugia malayi Cell division protein ftsZ 0.0114 0.2168 0.2168
Entamoeba histolytica P-glycoprotein-2 0.0021 0.0243 0.0022
Echinococcus granulosus Tubulin alpha 1 chain 0.0362 0.7298 0.7298
Leishmania major beta tubulin 0.0492 1 1
Echinococcus granulosus netrin receptor unc 5 0.0086 0.1592 0.1592
Loa Loa (eye worm) tubulin alpha 2 0.0248 0.494 0.494
Trichomonas vaginalis tubulin epsilon chain, putative 0.0362 0.7298 0.7267
Echinococcus granulosus death domain containing protein 0.0086 0.1592 0.1592
Trichomonas vaginalis tubulin epsilon chain, putative 0.0362 0.7298 0.7267
Schistosoma mansoni tubulin subunit beta 0.0492 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.0492 1 1
Loa Loa (eye worm) tubulin beta-1 chain 0.0492 1 1
Trypanosoma brucei epsilon tubulin 0.0262 0.524 0.5132
Plasmodium falciparum alpha tubulin 2 0.0362 0.7298 0.7237
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0248 0.494 0.494
Toxoplasma gondii beta-1 tubulin, putative 0.0492 1 1
Trypanosoma cruzi zeta tubulin, putative 0.0114 0.2168 0.1991
Mycobacterium tuberculosis Cell division protein FtsZ 0.0114 0.2168 0.416
Leishmania major beta tubulin 0.0492 1 1
Schistosoma mansoni hypothetical protein 0.0086 0.1592 0.1592
Loa Loa (eye worm) hypothetical protein 0.0086 0.1592 0.1592
Loa Loa (eye worm) tubulin beta-2A chain 0.0492 1 1
Leishmania major beta tubulin 0.0492 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0243 0.0243
Leishmania major alpha tubulin 0.0362 0.7298 0.7237
Leishmania major alpha tubulin 0.0362 0.7298 0.7237
Loa Loa (eye worm) alpha-tubulin 0.0362 0.7298 0.7298
Schistosoma mansoni lipoxygenase 0.0234 0.465 0.465
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.2168 0.2078
Brugia malayi Tubulin alpha-2 chain 0.0362 0.7298 0.7298
Echinococcus granulosus Tubulin beta 2C chain 0.0492 1 1
Plasmodium vivax delta tubulin, putative 0.0114 0.2168 0.1991
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0243 0.0131
Leishmania major beta tubulin 0.0492 1 1
Onchocerca volvulus 0.0039 0.062 0.1239
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0251 0.5001 0.4943
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.3441 0.6881
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0148 0.2882 0.2801
Loa Loa (eye worm) alpha-tubulin 0.0362 0.7298 0.7298
Loa Loa (eye worm) tubulin beta chain 0.0114 0.2168 0.2168
Schistosoma mansoni alpha tubulin 0.0362 0.7298 0.7298
Echinococcus multilocularis ATP binding cassette sub family B 0.002 0.0233 0.0233
Leishmania major alpha tubulin 0.0362 0.7298 0.7237
Echinococcus granulosus multidrug resistance protein 1 0.0015 0.0114 0.0114
Trypanosoma cruzi epsilon tubulin, putative 0.0262 0.524 0.5132
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0243 0.0131
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0234 0.465 0.465
Loa Loa (eye worm) tubulin beta chain 0.0492 1 1
Leishmania major alpha tubulin 0.0362 0.7298 0.7237
Trypanosoma brucei zeta tubulin, putative 0.0114 0.2168 0.1991
Loa Loa (eye worm) doublecortin family protein 0.0039 0.062 0.062
Plasmodium falciparum tubulin beta chain 0.0492 1 1
Leishmania major beta tubulin 0.0492 1 1
Trichomonas vaginalis abcb9, putative 0.0021 0.0243 0.0131
Giardia lamblia Beta tubulin 0.0492 1 1
Leishmania major alpha tubulin 0.0362 0.7298 0.7237
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0114 0.2168 0.1991
Loa Loa (eye worm) multidrug resistance protein 3 0.0021 0.0243 0.0243
Echinococcus multilocularis GPCR, family 2 0.0016 0.0137 0.0137

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.9 uM Displacement of [3H]rosiglitazone from PPAR gamma ChEMBL. 17574414
IC50 (binding) = 0.9 uM Displacement of [3H]rosiglitazone from PPAR gamma ChEMBL. 17574414

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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