Detailed information for compound 44947

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 265.307 | Formula: C9H17N2O5S-
  • H donors: 1 H acceptors: 5 LogP: -0.62 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(C(=O)[O-])CS(=O)(=N)CCC(C(=O)[O-])[NH3+]
  • InChi: 1S/C9H18N2O5S/c1-2-6(8(12)13)5-17(11,16)4-3-7(10)9(14)15/h6-7,11H,2-5,10H2,1H3,(H,12,13)(H,14,15)/p-1
  • InChiKey: VGETXURWLRBZAO-UHFFFAOYSA-M  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni SET domain protein 0.0034 0.0033 0.0269
Trypanosoma brucei DNA polymerase eta, putative 0.0119 0.0151 0.0523
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0114 0.2501
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0048 0.0382
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0003 0.0001
Mycobacterium ulcerans hypothetical protein 0.019 0.0249 0.5585
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0009 0.0075
Giardia lamblia DNA repair protein RAD52 0.1099 0.1502 0.5505
Loa Loa (eye worm) nuclear factor I 0.0014 0.0006 0.0065
Loa Loa (eye worm) hypothetical protein 0.0047 0.0051 0.0834
Brugia malayi intermediate filament protein 0.0026 0.0023 0.0029
Brugia malayi hypothetical protein 0.0016 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0053 0.0059 0.0987
Brugia malayi mbt repeat family protein 0.0047 0.0051 0.0067
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0014
Onchocerca volvulus 0.0433 0.0584 0.0582
Echinococcus granulosus exonuclease 1 0.0017 0.0009 0.0063
Mycobacterium tuberculosis Conserved hypothetical protein 0.019 0.0249 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0114 0.2501
Entamoeba histolytica hypothetical protein 0.0079 0.0095 0.0571
Trichomonas vaginalis flap endonuclease-1, putative 0.0017 0.0009 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0124
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0003 0.0023
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0054 0.0061 0.0192
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0003 0.0001
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0003 0.0001
Giardia lamblia DNA damage repair protein 0.0029 0.0027 0.0064
Loa Loa (eye worm) hypothetical protein 0.0119 0.0151 0.2561
Echinococcus multilocularis geminin 0.0203 0.0266 0.2181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0003 0.0014
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0029 0.0226
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0018 0.0189
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0277
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0018 0.5
Schistosoma mansoni cpg binding protein 0.0106 0.0132 0.1092
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0114 0.0937
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0036 0.0036 0.0097
Loa Loa (eye worm) hypothetical protein 0.0056 0.0063 0.1045
Schistosoma mansoni microtubule-associated protein tau 0.0675 0.0917 0.7562
Schistosoma mansoni hypothetical protein 0.0067 0.0079 0.0648
Loa Loa (eye worm) hypothetical protein 0.0024 0.0019 0.0289
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0059 0.0478
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.0153 0.0528
Trypanosoma cruzi DNA polymerase kappa, putative 0.0121 0.0153 0.0528
Echinococcus multilocularis peregrin 0.0013 0.0004 0.0024
Schistosoma mansoni smad 0.0011 0.0002 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0003 0.0001
Loa Loa (eye worm) flap endonuclease-1 0.0082 0.01 0.168
Loa Loa (eye worm) MBCTL1 0.0053 0.0059 0.0987
Echinococcus multilocularis global transcription activator snf2l2 0.0146 0.0188 0.1536
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0029 0.0037
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0.0002 0.0004
Schistosoma mansoni ap endonuclease 0.0041 0.0043 0.0351
Onchocerca volvulus 0.0047 0.0051 0.0049
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0022 0.0166
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0023 0.0018 0.0051
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0017 0.0009 0.0063
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0114 0.0925
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0003 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.0153 0.0528
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0138
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0313 0.0418 0.2735
Echinococcus multilocularis dnaJ subfamily B 0.0889 0.1213 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0121 0.0153 0.0528
Trichomonas vaginalis DNA helicase recq, putative 0.0054 0.0061 0.1289
Echinococcus granulosus dna polymerase kappa 0.0121 0.0153 0.1247
Leishmania major mitochondrial DNA polymerase beta 0.0361 0.0484 0.1752
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0043 0.0855
Trichomonas vaginalis flap endonuclease-1, putative 0.0017 0.0009 0.0083
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0024 0.0019 0.0055
Giardia lamblia Telomerase catalytic subunit 0.1982 0.2721 1
Echinococcus multilocularis BRK domain containing protein 0.0025 0.0021 0.0161
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.0153 0.0528
Leishmania major modification methylase-like protein 0.0024 0.0019 0.0035
Brugia malayi Muscleblind-like protein 0.0325 0.0434 0.0595
Brugia malayi N-terminal motif family protein 0.0176 0.023 0.0314
Giardia lamblia Sgs1 DNA helicase, putative 0.0046 0.005 0.0151
Echinococcus granulosus dna polymerase eta 0.0119 0.0151 0.1234
Brugia malayi Flap endonuclease-1 0.0082 0.01 0.0135
Brugia malayi polk-prov protein 0.0056 0.0063 0.0084
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0138
Trypanosoma brucei unspecified product 0.0114 0.0144 0.0495
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0009 0.0062
Trichomonas vaginalis DNA helicase recq, putative 0.0085 0.0103 0.2266
Echinococcus multilocularis microtubule associated protein 2 0.0675 0.0917 0.7559
Echinococcus multilocularis exonuclease 1 0.0017 0.0009 0.0063
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0094 0.0116 0.0959
Loa Loa (eye worm) hypothetical protein 0.0176 0.023 0.3914
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0022 0.0166
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0063 0.0197
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0023 0.0018 0.0031
Echinococcus multilocularis flap endonuclease GEN 1 0.0017 0.0009 0.0063
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0114 0.2501
Brugia malayi ImpB/MucB/SamB family protein 0.0094 0.0116 0.0158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0003 0.0014
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.002 0.0041
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0043 0.0697
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0048 0.0395
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0082 0.01 0.0334
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0012 0.0088
Echinococcus granulosus Smad4 0.0026 0.0022 0.0166
Plasmodium falciparum DEAD/DEAH box helicase, putative 0.0023 0.0018 0.0051
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0079 0.0095 0.0767
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0012 0.0002 0.0008
Trypanosoma brucei DNA polymerase IV, putative 0.0121 0.0153 0.0528
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.0153 0.0528
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0003 0.0023
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0003 0.0011
Schistosoma mansoni smad1 5 8 and 0.0026 0.0022 0.0178
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0003 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.0153 0.0528
Echinococcus multilocularis Helicase SANT associated, DNA binding 0.0013 0.0004 0.0018
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0009 0.0062
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0024 0.0019 0.0035
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.0251 0.2061
Schistosoma mansoni Smad4 0.0026 0.0022 0.0178
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0034 0.0033 0.0257
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0072 0.023
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0018 0.006
Loa Loa (eye worm) helicase DNA-binding protein 0.0025 0.0021 0.0327
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0114 0.0385
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0072 0.1211
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0048 0.0395
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0063 0.0197
Echinococcus multilocularis dna polymerase kappa 0.0121 0.0153 0.1247
Brugia malayi glutaminase DH11.1 0.0327 0.0437 0.0599
Echinococcus granulosus helicase 0.0013 0.0004 0.0018
Schistosoma mansoni hypothetical protein 0.0203 0.0266 0.2191
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0018
Trypanosoma cruzi DNA polymerase kappa, putative 0.0121 0.0153 0.0528
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0072 0.0597
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0018 0.0033
Echinococcus granulosus importin subunit beta 1 0.0034 0.0034 0.0266
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0077 0.0092 0.0327
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0368 0.0494 0.8457
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0138
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0051 0.0404
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0051 0.0416
Trypanosoma cruzi DNA polymerase eta, putative 0.0119 0.0151 0.0523
Trichomonas vaginalis lymphoid specific helicase, putative 0.0027 0.0023 0.0398
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0056 0.0173
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0121 0.0153 0.3404
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0003 0.0001
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0043 0.0855
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0121 0.2051
Echinococcus multilocularis BRK domain containing protein 0.0025 0.0021 0.0161
Schistosoma mansoni lamin 0.0026 0.0023 0.0186
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0054 0.0061 0.0192
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0014
Schistosoma mansoni hypothetical protein 0.0203 0.0266 0.2191
Plasmodium vivax exonuclease I, putative 0.0017 0.0009 0.002
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0018 0.0056
Schistosoma mansoni helicase 0.0146 0.0188 0.1547
Echinococcus granulosus intermediate filament protein 0.0026 0.0023 0.0173
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0072 0.0585
Trypanosoma brucei DNA polymerase kappa, putative 0.0101 0.0125 0.0428
Mycobacterium ulcerans glutaminase 0.0327 0.0437 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.001 0.0054
Loa Loa (eye worm) BRM protein 0.0075 0.009 0.1518
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0043 0.0338
Trichomonas vaginalis flap endonuclease-1, putative 0.0017 0.0009 0.0083
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0018 0.0392
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0003 0.0023
Echinococcus multilocularis lamin 0.0026 0.0023 0.0173
Brugia malayi isocitrate dehydrogenase 0.0019 0.0012 0.0014
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0027 0.0064
Trichomonas vaginalis flap endonuclease-1, putative 0.0082 0.01 0.218
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1982 0.2721 1
Brugia malayi Smad1 0.0026 0.0022 0.0027
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0017 0.0009 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0003 0.0001
Plasmodium vivax DNA repair protein REV1, putative 0.0029 0.0027 0.0084
Leishmania major hypothetical protein, conserved 0.0025 0.002 0.0041
Brugia malayi ImpB/MucB/SamB family protein 0.0119 0.0151 0.0205
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0029 0.0226
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.001 0.5
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0051 0.0049
Loa Loa (eye worm) XPG I-region family protein 0.0017 0.0009 0.0124
Schistosoma mansoni intermediate filament proteins 0.0026 0.0023 0.0186
Trichomonas vaginalis exonuclease%2C+putative 0.0017 0.0009 0.0083
Echinococcus granulosus tar DNA binding protein 0.0063 0.0072 0.0585
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0003 0.0001
Plasmodium vivax DNA repair protein RAD2, putative 0.0017 0.0009 0.002
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0072 0.0097
Echinococcus multilocularis BRK domain containing protein 0.0025 0.0021 0.0161
Echinococcus multilocularis BRK domain 0.0025 0.0021 0.0161
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0133 0.017 0.1404
Echinococcus multilocularis cpg binding protein 0.0106 0.0132 0.1081
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0043 0.0338
Schistosoma mansoni smad1 5 8 and 0.0026 0.0022 0.0178
Schistosoma mansoni hypothetical protein 0.0031 0.0029 0.0238
Loa Loa (eye worm) hypothetical protein 0.0325 0.0434 0.7428
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0114 0.0925
Echinococcus multilocularis helicase 0.0013 0.0004 0.0018
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0043 0.1409
Loa Loa (eye worm) histone methyltransferase 0.002 0.0014 0.0211
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0048 0.0395
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0072 0.0597
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0012 0.0011
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0019 0.0035
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0024 0.0019 0.0142
Schistosoma mansoni helicase 0.0013 0.0004 0.003
Echinococcus granulosus smad 0.0026 0.0022 0.0166
Entamoeba histolytica hypothetical protein 0.0079 0.0095 0.0571
Schistosoma mansoni hypothetical protein 0.0029 0.0026 0.0214
Echinococcus granulosus dnaJ subfamily B 0.0889 0.1213 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0101 0.0126 0.0449
Trypanosoma brucei DNA polymerase IV, putative 0.0121 0.0153 0.0528
Toxoplasma gondii exonuclease III APE 0.0041 0.0043 0.0123
Leishmania major DNA polymerase kappa, putative 0.0101 0.0125 0.0428
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0067 0.0079 0.1316
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0003 0.0023
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0023 0.0353
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0114 0.2501
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.0153 0.0528
Onchocerca volvulus 0.0013 0.0004 0.0002
Schistosoma mansoni blooms syndrome DNA helicase 0.0061 0.0071 0.0583
Echinococcus multilocularis Chromo domain 0.0025 0.0021 0.0161
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0022 0.0166
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.002 0.0062
Loa Loa (eye worm) hypothetical protein 0.0433 0.0584 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0003 0.0011
Schistosoma mansoni hypothetical protein 0.0292 0.0389 0.3205
Echinococcus multilocularis smad 0.0026 0.0022 0.0166
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0022 0.0337
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0043 0.0223
Echinococcus multilocularis BRK domain containing protein 0.0025 0.0021 0.0161
Onchocerca volvulus 0.0046 0.005 0.0048
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0025 0.0442
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0114 0.0699
Entamoeba histolytica recQ family DNA helicase 0.0024 0.0019 0.0064
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0049 0.101
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0114 0.2501
Echinococcus granulosus BRK domain containing protein 0.0025 0.0021 0.0161
Plasmodium vivax importin-beta 2, putative 0.0034 0.0034 0.0111
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0003 0.0001
Toxoplasma gondii RNA-directed DNA polymerase 0.1982 0.2721 1
Schistosoma mansoni helicase 0.0013 0.0004 0.003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0048 0.0382
Loa Loa (eye worm) glutaminase 2 0.0327 0.0437 0.748
Toxoplasma gondii hypothetical protein 0.0101 0.0126 0.043
Trypanosoma brucei DNA polymerase kappa, putative 0.0072 0.0085 0.0279
Echinococcus granulosus neuropeptide receptor A26 0.0452 0.061 0.5024
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0034 0.009
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0018 0.0189
Echinococcus granulosus microtubule associated protein 2 0.0675 0.0917 0.7559
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0121 0.0165
Leishmania major DNA polymerase eta, putative 0.0054 0.0061 0.0192
Brugia malayi hypothetical protein 0.0433 0.0584 0.0801
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0018 0.0023
Toxoplasma gondii hypothetical protein 0.0058 0.0067 0.0211
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0003 0.0011
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0024 0.0019 0.0154
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0046 0.005 0.0402
Mycobacterium ulcerans DNA polymerase IV 0.0121 0.0153 0.3336
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0024 0.0019 0.0055
Trichomonas vaginalis DNA helicase recq1, putative 0.0085 0.0103 0.2266
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0082 0.01 0.0334
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family member 0.0017 0.0009 0.0076
Schistosoma mansoni glutaminase 0.0327 0.0437 0.3604
Brugia malayi ecdysteroid receptor 0.0012 0.0003 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0049 0.101
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0014 0.0105
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0034 0.0266
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.023 0.0228
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0018 0.0189
Trypanosoma brucei DNA polymerase kappa, putative 0.0072 0.0085 0.0279
Trichomonas vaginalis DNA polymerase eta, putative 0.0121 0.0153 0.3404
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0029 0.0037
Plasmodium falciparum DNA repair protein RAD2, putative 0.0017 0.0009 0.002
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0034 0.009
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0072 0.0597
Entamoeba histolytica deoxycytidyl transferase, putative 0.0094 0.0116 0.0717
Giardia lamblia Flap structure-specific endonuclease 0.0082 0.01 0.0334
Brugia malayi MH2 domain containing protein 0.0026 0.0022 0.0027
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0072 0.0597
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0018 0.0033
Schistosoma mansoni terminal deoxycytidyl transferase 0.0094 0.0116 0.0959
Loa Loa (eye worm) transcription factor SMAD2 0.0377 0.0507 0.8677
Schistosoma mansoni hypothetical protein 0.0368 0.0494 0.4073
Loa Loa (eye worm) hypothetical protein 0.0026 0.0023 0.0353
Echinococcus multilocularis BRK domain containing protein 0.0025 0.0021 0.0161
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0051 0.0404
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.0153 0.0528
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0024 0.0019 0.0035
Echinococcus multilocularis snurportin 1 0.0368 0.0494 0.4066
Echinococcus granulosus global transcription activator snf2l2 0.0146 0.0188 0.1536
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0043 0.5
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.0251 0.2061
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.0318
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0003 0.0011
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0018 0.0189
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0098 0.0121 0.2051
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0003 0.0011
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0061 0.0192
Echinococcus granulosus geminin 0.0203 0.0266 0.2181
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0072 0.0597
Trypanosoma cruzi DNA damage repair protein, putative 0.0029 0.0027 0.0064
Echinococcus granulosus lamin dm0 0.0026 0.0023 0.0173
Echinococcus multilocularis disco interacting protein 2 0.0047 0.0051 0.0408
Plasmodium falciparum exonuclease I, putative 0.0017 0.0009 0.002
Schistosoma mansoni smad 0.0026 0.0022 0.0178
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0018 0.006
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0012 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0003 0.0014
Onchocerca volvulus 0.0012 0.0003 0.0001
Brugia malayi MH1 domain containing protein 0.0014 0.0006 0.0006
Brugia malayi Associated with TFs and helicases family protein 0.0025 0.0021 0.0027
Plasmodium falciparum telomerase reverse transcriptase 0.1982 0.2721 1
Echinococcus multilocularis flap endonuclease 1 0.0082 0.01 0.081
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0003 0.0023
Schistosoma mansoni hypothetical protein 0.0031 0.0029 0.0238
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0034 0.0033 0.0257
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0003 0.0014
Leishmania major DNA damage repair protein, putative 0.0029 0.0027 0.0064
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0051 0.0404
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0059 0.049
Schistosoma mansoni hypothetical protein 0.0079 0.0095 0.0779
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0079 0.0106
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0029 0.0226
Entamoeba histolytica Flap nuclease, putative 0.0082 0.01 0.0606
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0003 0.0011
Mycobacterium ulcerans hypothetical protein 0.0029 0.0027 0.0386
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0.0002 0.0004
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0101 0.0125 0.4859
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0043 0.0143
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0171 0.0222 0.0784
Onchocerca volvulus 0.0026 0.0023 0.0021
Trypanosoma brucei polo-like protein kinase 0.0092 0.0114 0.0385
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0114 0.2501
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0059 0.0478
Leishmania major telomerase reverse transcriptase, putative 0.1982 0.2721 1
Echinococcus granulosus snurportin 1 0.0368 0.0494 0.4066
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0114 0.0154
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0003 0.0001
Plasmodium vivax helicase, putative 0.0013 0.0004 0.0000029151
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.002 0.0041
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0003 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0018 0.0189
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0463
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0014
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0027 0.0023 0.005
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0043 0.0123
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1982 0.2721 1
Schistosoma mansoni coup transcription factor 0.0012 0.0003 0.0023
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0029 0.0226
Schistosoma mansoni Smad4 0.0011 0.0002 0.0017
Trypanosoma cruzi DNA polymerase kappa, putative 0.0121 0.0153 0.0528
Loa Loa (eye worm) Smad1 0.0026 0.0022 0.0337
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.001 0.0023
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0046 0.005 0.083
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0022 0.0178
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0056 0.0173
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0171 0.0222 0.0784
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0003 0.0011
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0023 0.0029
Schistosoma mansoni kinase 0.0047 0.0051 0.042
Entamoeba histolytica hypothetical protein 0.0313 0.0418 0.2735
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0277
Brugia malayi MH1 domain containing protein 0.0026 0.0022 0.0027
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0056 0.0173
Schistosoma mansoni cpg binding protein 0.0102 0.0128 0.1052
Brugia malayi MH2 domain containing protein 0.0026 0.0022 0.0027
Schistosoma mansoni transcription factor LCR-F1 0.0079 0.0095 0.0779
Brugia malayi CXXC zinc finger family protein 0.0102 0.0128 0.0173
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0048 0.0063
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0022 0.0337
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0043 0.0123
Schistosoma mansoni exonuclease 0.0017 0.0009 0.0076
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0024 0.0019 0.0064
Loa Loa (eye worm) runx1 0.0054 0.0061 0.1016
Entamoeba histolytica hypothetical protein 0.0079 0.0095 0.0571
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0046 0.005 0.0171
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0082 0.01 0.0334
Echinococcus granulosus peregrin 0.0013 0.0004 0.0024
Echinococcus multilocularis neuropeptide s receptor 0.0452 0.061 0.5024
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0043 0.0123
Onchocerca volvulus 0.0023 0.0018 0.0016
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0361 0.0484 0.1752
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0138
Loa Loa (eye worm) hypothetical protein 0.0046 0.005 0.082
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0003 0.0001
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0056 0.0173
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0027 0.0064
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0012 0.0101
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0012 0.0088
Giardia lamblia DINP protein human, muc B family 0.0101 0.0125 0.0428
Schistosoma mansoni ap endonuclease 0.0041 0.0043 0.0351
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0051 0.0404
Echinococcus granulosus bloom syndrome protein 0.0085 0.0103 0.0841
Loa Loa (eye worm) SNF2 family domain-containing protein 0.0013 0.0004 0.0029
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0012 0.0011
Trypanosoma brucei DNA damage repair protein, putative 0.0029 0.0027 0.0064
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0114 0.0385
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0046 0.005 0.0067
Echinococcus granulosus Chromo domain 0.0025 0.0021 0.0161
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0012 0.0011
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0051 0.0834
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0114 0.0112
Schistosoma mansoni phd finger protein 0.0013 0.0004 0.0037
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0051 0.0416
Echinococcus granulosus DNA methyltransferase 2, putative 0.0024 0.0019 0.0142
Brugia malayi hypothetical protein 0.0079 0.0095 0.0128
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0054 0.0061 0.0192
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0003 0.0023
Brugia malayi Telomerase reverse transcriptase 0.5274 0.7265 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0009 0.0062
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0043 0.0123
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0003 0.0001
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0029 0.0027 0.0064
Trypanosoma brucei telomerase reverse transcriptase 0.1982 0.2721 1
Entamoeba histolytica recQ family helicase, putative 0.0054 0.0061 0.0349
Loa Loa (eye worm) MH2 domain-containing protein 0.0377 0.0507 0.8677
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0012 0.0014
Trypanosoma brucei DNA damage repair protein, putative 0.0029 0.0027 0.0064
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0012 0.0002 0.0008
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0009 0.0062
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0094 0.0116 0.0948
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0114 0.0385
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0003 0.0011
Echinococcus multilocularis neuropeptide receptor A26 0.0452 0.061 0.5024
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0171 0.0222 0.0784
Trypanosoma brucei DNA polymerase IV, putative 0.0114 0.0144 0.0495
Schistosoma mansoni DNA polymerase eta 0.0119 0.0151 0.1245
Loa Loa (eye worm) hypothetical protein 0.0325 0.0434 0.7428
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0003 0.0001
Toxoplasma gondii histone lysine methyltransferase SET1 0.0123 0.0156 0.0542
Trypanosoma brucei unspecified product 0.0065 0.0076 0.0246
Loa Loa (eye worm) glutaminase 0.0327 0.0437 0.748
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0046 0.005 0.0402
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0054 0.0061 0.0211
Leishmania major importin beta-1 subunit, putative 0.0028 0.0025 0.0057
Brugia malayi SNF2 family N-terminal domain containing protein 0.0013 0.0004 0.0003
Brugia malayi Disco-interacting protein 2 homolog 0.0046 0.005 0.0066
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0004 0.0018
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0048 0.0788
Trypanosoma brucei chrX additional, unordered contigs 0.0029 0.0027 0.0064
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.001 0.0023
Brugia malayi BRM protein 0.0146 0.0188 0.0256
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0043 0.0761
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0014 0.0017
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0121 0.0165
Onchocerca volvulus 0.0026 0.0023 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0003 0.0001
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0012 0.0145
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0361 0.0484 0.1752
Schistosoma mansoni hypothetical protein 0.0889 0.1213 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0124
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0018 0.0023
Schistosoma mansoni cpg binding protein 0.0106 0.0132 0.1092
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0003 0.0023
Schistosoma mansoni DNA helicase recq5 0.0046 0.005 0.0415
Brugia malayi MH1 domain containing protein 0.0026 0.0022 0.0027
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.002 0.0041
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0054 0.0061 0.0192
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0094 0.0116 0.1965
Loa Loa (eye worm) BRM protein 0.0093 0.0115 0.1938
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0053 0.006 0.0186
Echinococcus multilocularis Protein lozenge 0.0054 0.0061 0.0492
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0003 0.0011
Schistosoma mansoni DNA helicase recq1 0.0046 0.005 0.0415
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.0153 0.0528
Echinococcus granulosus flap endonuclease 1 0.0082 0.01 0.081
Schistosoma mansoni SET domain protein 0.0015 0.0007 0.0061
Brugia malayi hypothetical protein 0.0025 0.002 0.0026
Schistosoma mansoni DNA polymerase IV / kappa 0.0029 0.0027 0.0219
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0014
Echinococcus multilocularis bloom syndrome protein 0.0085 0.0103 0.0841
Schistosoma mansoni hypothetical protein 0.0011 0.0002 0.0013
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0019 0.0035
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0029 0.0463
Leishmania major DNA polymerase kappa, putative 0.0029 0.0027 0.0064
Brugia malayi nuclear receptor NHR-88 0.0012 0.0003 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0138
Brugia malayi XPG I-region family protein 0.0017 0.0009 0.001
Brugia malayi steroid hormone receptor 0.0012 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0277
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0361 0.0484 0.1752
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0046 0.005 0.0067
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0046 0.005 0.0402
Schistosoma mansoni importin beta-1 0.0034 0.0034 0.0278
Echinococcus multilocularis BRK domain containing protein 0.0025 0.0021 0.0161
Loa Loa (eye worm) RNA binding protein 0.0063 0.0072 0.1211
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0047 0.0051 0.0421
Schistosoma mansoni smad1 5 8 and 0.0026 0.0022 0.0178
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0018 0.0189
Loa Loa (eye worm) CXXC zinc finger family protein 0.0102 0.0128 0.2158
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0.0002 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0003 0.0011
Echinococcus granulosus disco interacting protein 2 0.0047 0.0051 0.0408
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.002 0.0041
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0043 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0048 0.0382
Echinococcus multilocularis muscleblind protein 0.0325 0.0434 0.3571
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0014 0.0105
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0018 0.0033
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0018 0.006
Loa Loa (eye worm) hypothetical protein 0.0034 0.0034 0.0545
Giardia lamblia Kinase, PLK 0.0092 0.0114 0.0385
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0018 0.0392
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0059 0.0478
Mycobacterium tuberculosis Conserved hypothetical protein 0.0094 0.0116 0.4485
Entamoeba histolytica hypothetical protein 0.0079 0.0095 0.0571
Brugia malayi Bloom's syndrome protein homolog 0.0085 0.0103 0.014
Schistosoma mansoni hypothetical protein 0.0031 0.0029 0.0238
Plasmodium vivax flap endonuclease 1, putative 0.0082 0.01 0.0353
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0065
Loa Loa (eye worm) hypothetical protein 0.0026 0.0022 0.0341
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0025 0.0021 0.0161
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0012 0.0088
Schistosoma mansoni flap endonuclease-1 0.0074 0.0089 0.0732
Trichomonas vaginalis flap endonuclease-1, putative 0.0017 0.0009 0.0083
Toxoplasma gondii DNA methyltransferase 2, putative 0.0024 0.0019 0.0035
Loa Loa (eye worm) hypothetical protein 0.0046 0.005 0.083
Brugia malayi TAR-binding protein 0.0063 0.0072 0.0097
Echinococcus granulosus lamin 0.0026 0.0023 0.0173
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0114 0.1918
Schistosoma mansoni lamin 0.0026 0.0023 0.0186
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0006 0.0062
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0003 0.0011
Echinococcus multilocularis lamin dm0 0.0026 0.0023 0.0173
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0004 0.0018
Schistosoma mansoni hypothetical protein 0.0025 0.0021 0.0173
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0027 0.0064
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0023 0.0353
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0163 0.0211 0.3584
Mycobacterium ulcerans DNA polymerase IV 0.0121 0.0153 0.3336
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.1099 0.1502 1
Plasmodium vivax DEAD/DEAH helicase, putative 0.0023 0.0018 0.0051
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0046 0.005 0.0151
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0094 0.0116 0.0948
Brugia malayi mbt repeat family protein 0.0047 0.0051 0.0067
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0003 0.0011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0003 0.0011
Trichomonas vaginalis glutaminase, putative 0.0327 0.0437 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0101 0.0125 0.0428
Loa Loa (eye worm) hypothetical protein 0.0433 0.0584 1
Schistosoma mansoni hypothetical protein 0.0031 0.0029 0.0238
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0027 0.0064
Schistosoma mansoni lozenge 0.0054 0.0061 0.0504
Schistosoma mansoni blooms syndrome DNA helicase 0.0024 0.0019 0.0155
Plasmodium vivax telomerase reverse transcriptase, putative 0.1982 0.2721 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.002 0.0062
Echinococcus multilocularis muscleblind protein 1 0.0325 0.0434 0.3571
Echinococcus multilocularis dna polymerase eta 0.0119 0.0151 0.1234
Brugia malayi MH2 domain containing protein 0.0377 0.0507 0.0695
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0043 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0003 0.0001
Echinococcus multilocularis Smad4 0.0026 0.0022 0.0166
Echinococcus granulosus cpg binding protein 0.0106 0.0132 0.1081
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0003 0.0011
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0025 0.0442
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0018 0.5
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0059 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0003 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0048 0.0382
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0114 0.2501
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0072 0.1211
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0003 0.0011
Echinococcus granulosus Helicase SANT associated DNA binding 0.0013 0.0004 0.0018
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0012 0.0088
Onchocerca volvulus 0.0102 0.0128 0.0126
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0043 0.0143
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0018 0.0189
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0017 0.0009 0.0076
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0014
Entamoeba histolytica hypothetical protein 0.0028 0.0025 0.0104
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0082 0.01 0.0334
Echinococcus multilocularis GPCR, family 2 0.0031 0.0029 0.0226
Trypanosoma brucei DNA polymerase kappa, putative 0.0121 0.0153 0.0528
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0046 0.005 0.0151
Echinococcus granulosus flap endonuclease GEN 1 0.0017 0.0009 0.0063
Echinococcus granulosus muscleblind protein 0.0325 0.0434 0.3571
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0012 0.0088
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0006 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0072 0.0085 0.0279
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0012 0.0031
Loa Loa (eye worm) RecQ helicase 0.0085 0.0103 0.1744
Brugia malayi RNA, U transporter 1 0.0098 0.0121 0.0165
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0.0002 0.0004
Mycobacterium ulcerans hypothetical protein 0.0023 0.0018 0.0189
Brugia malayi nuclear hormone receptor 0.0012 0.0003 0.0001
Echinococcus multilocularis musashi 0.0026 0.0023 0.0173
Leishmania major DNA polymerase eta, putative 0.0119 0.0151 0.0523
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0012 0.0031
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0019 0.0035
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0012 0.0011
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0034 0.009
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0018 0.0023
Trypanosoma cruzi DNA damage repair protein, putative 0.0029 0.0027 0.0064
Plasmodium falciparum importin beta, putative 0.0034 0.0034 0.0111
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0014
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0022 0.0166
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0012 0.0011
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0012 0.0011
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0003 0.0014
Plasmodium falciparum DNA repair protein REV1, putative 0.0029 0.0027 0.0084
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0051 0.0416
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0043 0.0123
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0025 0.0057
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0003 0.0011
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.002 0.0062
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0003 0.0014
Echinococcus granulosus GPCR family 2 0.0031 0.0029 0.0226
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0046 0.005 0.0402
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0014
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0012 0.0176
Brugia malayi MH1 domain containing protein 0.0014 0.0006 0.0006
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0059 0.0478
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0079 0.0095 0.0767
Schistosoma mansoni hypothetical protein 0.0013 0.0004 0.003
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0025 0.0442
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0003 0.0023
Brugia malayi Importin beta-1 subunit 0.0034 0.0034 0.0044
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.0029
Echinococcus granulosus neuropeptide s receptor 0.0452 0.061 0.5024
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0003 0.0001
Plasmodium falciparum flap endonuclease 1 0.0082 0.01 0.0353
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0014
Brugia malayi RNA binding protein 0.0063 0.0072 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0003 0.0014
Schistosoma mansoni Smad4 0.0011 0.0002 0.0017
Trypanosoma brucei unspecified product 0.0065 0.0076 0.0246

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 98 % Compound was tested for the inhibition of E. coli gamma-glutamylcysteine synthetase at a concentration of 5.1 uM ChEMBL. No reference
K inact/Ki (binding) = 1206 M-1 s-1 Second order rate constant for time-dependent inhibition (Kinact/Ki) of E. coli gamma-glutamylcysteine synthetase at a concentration of 5.1 uM. ChEMBL. No reference
Ki (binding) = 0.39 uM Tested for inhibition of E. coli gamma-glutamylcysteine synthetase at a concentration of 5.1 microM. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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