Detailed information for compound 450511

Basic information

Technical information
  • TDR Targets ID: 450511
  • Name: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl- 1-[(2S)-1-[2-(1-methylcyclohexyl)prop-2-enoxy ]propan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden -4-ylidene]ethylidene]-4-methylidenecyclohexa ne-1,3-diol
  • MW: 482.738 | Formula: C32H50O3
  • H donors: 2 H acceptors: 2 LogP: 7.72 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1C[C@H](O)C(=C)/C(=C\C=C\2/CCC[C@]3([C@H]2CC[C@@H]3[C@@H](COCC(=C)C2(C)CCCCC2)C)C)/C1
  • InChi: 1S/C32H50O3/c1-22(20-35-21-23(2)31(4)15-7-6-8-16-31)28-13-14-29-25(10-9-17-32(28,29)5)11-12-26-18-27(33)19-30(34)24(26)3/h11-12,22,27-30,33-34H,2-3,6-10,13-21H2,1,4-5H3/b25-11+,26-12-/t22-,27-,28-,29+,30+,32-/m1/s1
  • InChiKey: FPHQUCPOSFFTBY-JJWDWHEPSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(1S)-1-methyl-2-[2-(1-methylcyclohexyl)allyloxy]ethyl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-cyclohexane-1,3-diol
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(1S)-1-methyl-2-[2-(1-methylcyclohexyl)allyloxy]ethyl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylenecyclohexane-1,3-diol
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2S)-1-[2-(1-methylcyclohexyl)prop-2-enoxy]propan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(1S)-1-methyl-2-[2-(1-methylcyclohexyl)prop-2-enoxy]ethyl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-cyclohexane-1,3-diol
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(1S)-1-methyl-2-[2-(1-methylcyclohexyl)prop-2-enoxy]ethyl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylenecyclohexane-1,3-diol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi steroid hormone receptor vitamin D (1,25- dihydroxyvitamin D3) receptor 427 aa 416 aa 24.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0206 0.4358
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0096 0.0646
Leishmania major cathepsin L-like protease 0.0018 0.0069 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0069 0.0101
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0066 0.139
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0025 0.0039
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0025 0.0039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0158 0.0244
Schistosoma mansoni tar DNA-binding protein 0.0064 0.045 0.0696
Toxoplasma gondii 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase domain-containing protein 0.0592 0.4733 1
Leishmania major cathepsin L-like protease 0.0018 0.0069 0.0009
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0069 0.0107
Entamoeba histolytica hypothetical protein 0.0038 0.0234 0.0571
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0195
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.045 0.3033
Schistosoma mansoni cytochrome P450 0.0017 0.0066 0.0102
Onchocerca volvulus 0.0057 0.0385 0.2168
Schistosoma mansoni cpg binding protein 0.006 0.0411 0.0636
Entamoeba histolytica hypothetical protein 0.0038 0.0234 0.0571
Brugia malayi bZIP transcription factor family protein 0.0089 0.0649 0.4376
Brugia malayi nuclear receptor NHR-88 0.0012 0.0025 0.017
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0025 0.0086
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0025 0.0039
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0025 0.0037
Toxoplasma gondii cytochrome p450 superfamily protein 0.0017 0.0066 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0025 0.017
Loa Loa (eye worm) hypothetical protein 0.0018 0.0069 0.0387
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0025 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.1241 1 1
Schistosoma mansoni hypothetical protein 0.0017 0.0066 0.0102
Echinococcus granulosus RUN 0.0099 0.0728 0.1127
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0025 0.0039
Leishmania major cathepsin L-like protease 0.0018 0.0069 0.0009
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0013 0.0268
Loa Loa (eye worm) hypothetical protein 0.0083 0.0601 0.4004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0025 0.017
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.105
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0069 0.0169
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0025 0.0086
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0069 0.1472
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.024 0.1875 0.2291
Loa Loa (eye worm) hypothetical protein 0.0159 0.1219 0.8208
Schistosoma mansoni DNA helicase recq1 0.0021 0.0096 0.0148
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0069 0.0283
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0234 0.0362
Echinococcus multilocularis GPCR, family 2 0.0014 0.0043 0.0063
Echinococcus multilocularis cysteine protease 0.0018 0.0069 0.0101
Echinococcus multilocularis RUN 0.0099 0.0728 0.1061
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0046 0.0297 0.2001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0086
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0025 0.0039
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0076 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0025 0.017
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.003 0.003
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0855 0.6863 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0041 0.0195
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0013 0.0268
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0069 0.0069
Loa Loa (eye worm) fibroinase 0.0018 0.0069 0.0387
Loa Loa (eye worm) hypothetical protein 0.0099 0.0728 0.4871
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.0991 0.7964 1
Leishmania major cytochrome p450-like protein 0.0034 0.0206 0.0347
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.003
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0025 0.0019
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0076 0.0118
Onchocerca volvulus 0.0099 0.0728 0.4218
Brugia malayi CXXC zinc finger family protein 0.0057 0.0385 0.2599
Brugia malayi latrophilin 2 splice variant baaae 0.0031 0.0179 0.121
Trichomonas vaginalis set domain proteins, putative 0.0218 0.1696 0.1696
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0086
Echinococcus multilocularis geminin 0.0179 0.1376 0.2005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0022 0.0022
Brugia malayi Pre-SET motif family protein 0.0029 0.0158 0.1066
Echinococcus multilocularis 0.0017 0.0066 0.0096
Brugia malayi Cytochrome P450 family protein 0.0034 0.0206 0.1387
Entamoeba histolytica hypothetical protein 0.0038 0.0234 0.0571
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Schistosoma mansoni hypothetical protein 0.0031 0.0179 0.0277
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0064
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0086
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0066 0.139
Onchocerca volvulus 0.0018 0.0069 0.0283
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0304 0.0471
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0033 0.0195 0.4132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0025 0.0086
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0033 0.0195 0.013
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0096 0.0183
Loa Loa (eye worm) hypothetical protein 0.0021 0.0096 0.0566
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0206 0.1313
Brugia malayi Death domain containing protein 0.0014 0.0041 0.0278
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0025 0.017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0069 0.0469
Echinococcus granulosus geminin 0.0179 0.1376 0.2129
Schistosoma mansoni lipoxygenase 0.0224 0.1745 0.2701
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.0908 0.1405
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0025 0.017
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0096 0.0646
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0158 0.0315
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0304 0.0471
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0425 0.8997
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0025 0.0039
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0201
Schistosoma mansoni hypothetical protein 0.0073 0.0519 0.0802
Schistosoma mansoni hypothetical protein 0.0038 0.0234 0.0362
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0263 0.2064 0.2531
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0069 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0099 0.0728 0.4871
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0472 1
Leishmania major cathepsin L-like protease 0.0018 0.0069 0.0009
Loa Loa (eye worm) ctsf protein 0.0018 0.0069 0.0387
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0304 0.0443
Entamoeba histolytica recQ family helicase, putative 0.001 0.0009 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0025 0.017
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0025 0.0039
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0304 0.1984
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0086
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0025 0.0039
Plasmodium vivax vivapain-2 0.0018 0.0069 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Entamoeba histolytica cysteine protease, putative 0.0018 0.0069 0.0169
Schistosoma mansoni jun-related protein 0.0073 0.0519 0.0802
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0096 0.2029
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0033 0.0195 0.0412
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Brugia malayi Cathepsin L-like precursor 0.0012 0.0022 0.0149
Echinococcus granulosus cpg binding protein 0.006 0.0411 0.0636
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0304 0.0471
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.0472 1
Brugia malayi steroid hormone receptor 0.0012 0.0025 0.017
Loa Loa (eye worm) latrophilin receptor protein 2 0.0014 0.0043 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0069 0.0147
Onchocerca volvulus 0.0058 0.0399 0.2251
Brugia malayi hypothetical protein 0.0099 0.0728 0.4915
Leishmania major cathepsin L-like protease 0.0018 0.0069 0.0009
Onchocerca volvulus 0.0159 0.1219 0.7146
Echinococcus granulosus cathepsin l1 0.0012 0.0022 0.0034
Brugia malayi Uncoordinated protein 44 0.0014 0.0041 0.0278
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0014 0.0043 0.0067
Schistosoma mansoni coup transcription factor 0.0012 0.0025 0.0039
Echinococcus multilocularis jun protein 0.0089 0.0649 0.0945
Brugia malayi Pre-SET motif family protein 0.0192 0.1482 1
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0096 0.0646
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0014 0.0043 0.0067
Wolbachia endosymbiont of Brugia malayi 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0592 0.4733 0.5
Brugia malayi cytochrome P450 0.0017 0.0066 0.0443
Mycobacterium leprae Probable transmembrane transport protein 0.024 0.1875 0.4485
Loa Loa (eye worm) cysteine protease 0.0018 0.0069 0.0387
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0025 0.0039
Mycobacterium ulcerans integral membrane transporter 0.0033 0.0195 0.013
Schistosoma mansoni ephrin receptor 0.0059 0.0404 0.0626
Loa Loa (eye worm) cytochrome P450 0.0017 0.0066 0.0361
Schistosoma mansoni hypothetical protein 0.0179 0.1376 0.2129
Trypanosoma brucei cytochrome P450, putative 0.0034 0.0206 0.4358
Brugia malayi Cathepsin L-like precursor 0.0012 0.0022 0.0149
Schistosoma mansoni hypothetical protein 0.0014 0.0043 0.0067
Loa Loa (eye worm) hypothetical protein 0.0058 0.0399 0.263
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0069 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0025 0.0039
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0096 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.003
Brugia malayi RNA binding protein 0.0064 0.045 0.3033
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0025 0.0037
Schistosoma mansoni hypothetical protein 0.0099 0.0728 0.1127
Plasmodium vivax multidomain scavenger receptor, putative 0.0099 0.0728 0.1539
Schistosoma mansoni DNA helicase recq5 0.0021 0.0096 0.0148
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0025 0.0039
Brugia malayi cathepsin L-like precursor 0.0012 0.0022 0.0149
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0022 0.0054
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0234 0.0362
Echinococcus multilocularis cysteine protease 0.0018 0.0069 0.0101
Onchocerca volvulus 0.0018 0.0069 0.0283
Echinococcus granulosus neuropeptide s receptor 0.0487 0.3882 0.6006
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Entamoeba histolytica carbonic anhydrase, putative 0.0514 0.41 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.0059 0.0404 0.0589
Brugia malayi TAR-binding protein 0.0064 0.045 0.3033
Echinococcus granulosus lipoxygenase domain containing protein 0.0099 0.0728 0.1127
Echinococcus granulosus GPCR family 2 0.0014 0.0043 0.0067
Onchocerca volvulus 0.0029 0.0158 0.0811
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0025 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0025 0.017
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0048 0.0071
Schistosoma mansoni cpg binding protein 0.0057 0.0385 0.0596
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0069 0.0107
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0069 0.0101
Brugia malayi Calcitonin receptor-like protein seb-1 0.0046 0.0297 0.2001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0025 0.0086
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0096 0.0234
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0158 0.0244
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0025 0.0019
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0158 0.023
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0472 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0158 0.0244
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0192 0.1482 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0089 0.0649 0.0945
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0086
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0033 0.0195 0.013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0022 0.0022
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0234 0.0341
Onchocerca volvulus 0.0018 0.0069 0.0283
Echinococcus granulosus microtubule associated protein 2 0.0727 0.5829 0.9019
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0025 0.017
Mycobacterium leprae Probable 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF (MECPS) (MECDP-synthase ) 0.0475 0.3781 0.9207
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0017 0.0066 0.139
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0025 0.0037
Leishmania major carbonic anhydrase family protein, putative 0.0514 0.41 1
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0033 0.0195 0.4132
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0096 0.014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0025 0.0037
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.0804 0.1682
Echinococcus granulosus death domain containing protein 0.0014 0.0041 0.0064
Brugia malayi Doublecortin family protein 0.0099 0.0728 0.4915
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0025 0.0039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.003
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0014 0.0043 0.0293
Plasmodium vivax SET domain protein, putative 0.0029 0.0158 0.0334
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Echinococcus granulosus jun protein 0.0089 0.0649 0.1003
Onchocerca volvulus 0.0018 0.0069 0.0283
Brugia malayi hypothetical protein 0.0038 0.0234 0.1579
Plasmodium vivax vivapain-2 0.0018 0.0069 0.0147
Leishmania major cathepsin L-like protease 0.0067 0.0472 0.1007
Echinococcus granulosus neuropeptide receptor A26 0.0487 0.3882 0.6006
Brugia malayi ephrin receptor 1 precursor 0.0028 0.0154 0.1041
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0069 0.0283
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0402 0.3189 0.4935
Schistosoma mansoni hypothetical protein 0.0179 0.1376 0.2129
Brugia malayi Cathepsin L-like precursor 0.0018 0.0069 0.0469
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0025 0.0037
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0515 0.0751
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0025 0.0037
Brugia malayi nuclear hormone receptor 0.0012 0.0025 0.017
Echinococcus multilocularis neuropeptide s receptor 0.0487 0.3882 0.5656
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0014 0.0043 0.0067
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0069 0.0101
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0069 0.0469
Brugia malayi Latrophilin receptor protein 2 0.0014 0.0043 0.0293
Loa Loa (eye worm) TAR-binding protein 0.0064 0.045 0.2973
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0025 0.0086
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0009 0.002
Schistosoma mansoni polycystin 1-related 0.0099 0.0728 0.1127
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.045 0.2973
Mycobacterium ulcerans hypothetical protein 0.0111 0.0823 0.0763
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0096 0.0202
Schistosoma mansoni rab6-interacting 0.0099 0.0728 0.1127
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0096 0.2029
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0209
Entamoeba histolytica hypothetical protein 0.0038 0.0234 0.0571
Brugia malayi hypothetical protein 0.0159 0.1219 0.8223
Echinococcus multilocularis dnaJ subfamily B 0.0806 0.6463 0.9418
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0064
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0355 0.7525
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0026 0.014 0.0216
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0096 0.0148
Schistosoma mansoni tar DNA-binding protein 0.0064 0.045 0.0696
Echinococcus granulosus ephrin type A receptor 4 A 0.0059 0.0404 0.0626
Plasmodium falciparum 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0592 0.4733 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0025 0.0086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0158 0.0244
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0048 0.0075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0069 0.0469
Brugia malayi hypothetical protein 0.0067 0.0471 0.3178
Brugia malayi Cytochrome P450 family protein 0.0034 0.0206 0.1387
Schistosoma mansoni loxhd1 0.0099 0.0728 0.1127
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0025 0.0039
Echinococcus multilocularis microtubule associated protein 2 0.0727 0.5829 0.8494
Brugia malayi Cathepsin L-like precursor 0.0018 0.0069 0.0469
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0025 0.017
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0025 0.017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0304 0.0471
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0048 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Brugia malayi Cytochrome P450 family protein 0.0072 0.0512 0.3456
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0041 0.006
Brugia malayi ecdysteroid receptor 0.0012 0.0025 0.017
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0025 0.017
Trichomonas vaginalis conserved hypothetical protein 0.1241 1 1
Brugia malayi Protein kinase domain containing protein 0.0014 0.0041 0.0278
Onchocerca volvulus 0.0099 0.0728 0.4218
Echinococcus multilocularis lipoxygenase domain containing protein 0.0099 0.0728 0.1061
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0069 0.0387
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0017 0.0066 0.139
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0069 0.0147
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0206 0.4358
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0046 0.0297 0.1932
Echinococcus granulosus tar DNA binding protein 0.0064 0.045 0.0696
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0096 0.0566
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0069 0.0387
Trichomonas vaginalis helicase, putative 0.0013 0.003 0.003
Echinococcus granulosus cathepsin l1 0.0018 0.0069 0.0107
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0402 0.3189 0.4647
Schistosoma mansoni hypothetical protein 0.0014 0.0041 0.0064
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0096 0.0202
Loa Loa (eye worm) hypothetical protein 0.0046 0.0297 0.1932
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0013 0.0027
Schistosoma mansoni hypothetical protein 0.0806 0.6463 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0515 0.0797
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0086
Loa Loa (eye worm) CYP4Cod1 0.0034 0.0206 0.1313
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0048 0.0075
Loa Loa (eye worm) doublecortin family protein 0.0099 0.0728 0.4871
Schistosoma mansoni lipoxygenase 0.0402 0.3189 0.4935
Mycobacterium ulcerans 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0592 0.4733 0.4699
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0089 0.0649 0.1003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0514 0.41 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0013 0.0007
Brugia malayi Cytochrome P450 family protein 0.0017 0.0066 0.0443
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0042 0.0065
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0041 0.006
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0014 0.0043 0.0063
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0025 0.0039
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0041 0.0064
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0013 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0025 0.017
Onchocerca volvulus 0.0208 0.1614 0.9504
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0022 0.0149
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0014 0.0043 0.0063
Schistosoma mansoni tar DNA-binding protein 0.0064 0.045 0.0696
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0096 0.0096
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0009 0.0014
Schistosoma mansoni hypothetical protein 0.0014 0.0043 0.0067
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.003
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0025 0.0039
Loa Loa (eye worm) hypothetical protein 0.0017 0.0066 0.0365
Onchocerca volvulus 0.0067 0.0471 0.2681
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0025 0.0037
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0096 0.0183
Onchocerca volvulus 0.0018 0.0069 0.0283
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0989
Echinococcus multilocularis tar DNA binding protein 0.0064 0.045 0.0655
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0025 0.0039
Plasmodium vivax 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, putative 0.0592 0.4733 1
Loa Loa (eye worm) RecQ helicase 0.0021 0.0096 0.0566
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0033 0.0195 0.4132
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.003 0.003
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0096 0.0075
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0158 0.0244
Onchocerca volvulus 0.0012 0.0025 0.0019
Toxoplasma gondii cathepsin CPL 0.0018 0.0069 0.0127
Leishmania major cathepsin L-like protease 0.0067 0.0472 0.1007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0025 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0064 0.045 0.0696
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0025 0.017
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0304 0.2052
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0086
Loa Loa (eye worm) RNA binding protein 0.0064 0.045 0.2973
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0472 1
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0013 0.0031
Leishmania major cathepsin L-like protease 0.0067 0.0472 0.1007
Chlamydia trachomatis 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.0592 0.4733 1
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0096 0.014
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0069 0.0169
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0025 0.0039
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0096 0.0148
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0069 0.0147
Schistosoma mansoni hypothetical protein 0.0014 0.0043 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Mycobacterium tuberculosis Probable 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF (MECPS) 0.0475 0.3781 0.4704
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0472 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0025 0.0039
Echinococcus multilocularis lipoxygenase domain containing protein 0.0099 0.0728 0.1061
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0022 0.0034
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0491 0.3912 0.4869
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0041 0.0114
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0096 0.014
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0304 0.0443
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0069 0.0101
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0385 0.2535
Schistosoma mansoni carbonic anhydrase 0.0514 0.41 0.6344
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.0066 0.0102
Brugia malayi Cathepsin L-like precursor 0.0018 0.0069 0.0469
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0096 0.0096
Schistosoma mansoni netrin receptor unc5 0.0014 0.0041 0.0064
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0025 0.0037
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0025 0.017
Echinococcus granulosus lipoxygenase domain containing protein 0.0099 0.0728 0.1127
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.003 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0025 0.0086
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0041 0.0278
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0076 0.0434
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0069 0.0069
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0025 0.0019
Brugia malayi Cathepsin L-like precursor 0.0018 0.0069 0.0469
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0041 0.0064
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0025 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Echinococcus granulosus bloom syndrome protein 0.0021 0.0096 0.0148
Onchocerca volvulus 0.0018 0.0069 0.0283
Echinococcus multilocularis neuropeptide receptor A26 0.0487 0.3882 0.5656
Loa Loa (eye worm) TK/EPH protein kinase 0.0075 0.0534 0.3548
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0069 0.0069
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0033 0.0195 0.0393
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0041 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.003 0.003
Schistosoma mansoni rab6-interacting 0.0099 0.0728 0.1127
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0075 0.0503
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0048 0.0071
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0206 0.1313
Brugia malayi hypothetical protein 0.0099 0.0728 0.4915
Loa Loa (eye worm) hypothetical protein 0.0031 0.0179 0.1134
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0158 0.023
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0034 0.0206 0.0141
Echinococcus multilocularis Ankyrin 0.0014 0.0042 0.0061
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.0000000004757
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Onchocerca volvulus 0.0218 0.1697 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0025 0.017
Onchocerca volvulus 0.0018 0.0069 0.0283
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0096 0.0096
Echinococcus granulosus dnaJ subfamily B 0.0806 0.6463 1
Treponema pallidum hypothetical protein 0.0592 0.4733 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0099 0.0728 0.1061
Echinococcus granulosus Polycystic kidney disease protein 0.0099 0.0728 0.1127
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0304 0.0471
Loa Loa (eye worm) cytochrome P450 family protein 0.0072 0.0512 0.34
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0069 0.0283
Schistosoma mansoni microtubule-associated protein tau 0.0727 0.5829 0.9019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0069 0.0069
Mycobacterium ulcerans carbonic anhydrase 0.0514 0.41 0.4062
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0069 0.0107
Schistosoma mansoni cpg binding protein 0.006 0.0411 0.0636
Plasmodium vivax sulfate transporter, putative 0.0033 0.0195 0.0412
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0025 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0025 0.017
Onchocerca volvulus Putative sulfate transporter 0.0208 0.1614 0.9504
Plasmodium falciparum LCCL domain-containing protein 0.0099 0.0728 0.1539
Schistosoma mansoni tar DNA-binding protein 0.0064 0.045 0.0696
Echinococcus multilocularis cpg binding protein 0.006 0.0411 0.0599
Echinococcus granulosus Ankyrin 0.0014 0.0042 0.0065

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) < 0.02 Calciuric activity in rat utrine assessed as vitamine D3 level relative to calcitriol ChEMBL. 17924616
ED50 (binding) = 350 nM Activity at human recombinant VDR in ROS 17/2.8 cells transfected with growth hormone fusion gene VDRE assessed as growth hormone level by transcriptional assay ChEMBL. 17924616
ED50 (binding) = 350 nM Activity at human recombinant VDR in ROS 17/2.8 cells transfected with growth hormone fusion gene VDRE assessed as growth hormone level by transcriptional assay ChEMBL. 17924616
IC50 (functional) = 100 nM Antiproliferative activity against mouse keratinocytes ChEMBL. 17924616
IC50 (binding) = 198 nM Displacement of 1alpha, 25-(OH)[3H]D3 from human VDR expressed in COS1 cells ChEMBL. 17924616
IC50 (binding) = 198 nM Displacement of 1alpha, 25-(OH)[3H]D3 from human VDR expressed in COS1 cells ChEMBL. 17924616
LogP = 5.3 Lipophilicity, log D of the compound ChEMBL. 17924616

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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