Detailed information for compound 506950

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 368.431 | Formula: C23H20N4O
  • H donors: 2 H acceptors: 1 LogP: 4.53 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=N)NC(=O)Cn1c(ccc1c1ccccc1)c1cccc2c1cccc2
  • InChi: 1S/C23H20N4O/c24-23(25)26-22(28)15-27-20(17-8-2-1-3-9-17)13-14-21(27)19-12-6-10-16-7-4-5-11-18(16)19/h1-14H,15H2,(H4,24,25,26,28)
  • InChiKey: CSOHWCBHFNFCMC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0408 0.0571 0.1336
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0054 0.0156
Echinococcus multilocularis G-protein coupled receptor, putative 0.0408 0.0571 0.1336
Trichomonas vaginalis AGC family protein kinase 0.0047 0.0016 0.0182
Brugia malayi phosphoinositide-dependent protein kinase I 0.0047 0.0016 0.0015
Echinococcus granulosus rhodopsin orphan GPCR 0.0408 0.0571 0.1336
Schistosoma mansoni biogenic amine receptor 0.0408 0.0571 0.1006
Schistosoma mansoni adenosine deaminase-related 0.0092 0.0084 0.0147
Schistosoma mansoni calcium-activated potassium channel 0.0072 0.0055 0.0095
Echinococcus granulosus somatostatin receptor 0.0408 0.0571 0.1336
Onchocerca volvulus 0.0408 0.0571 0.4717
Onchocerca volvulus 0.0072 0.0054 0.0444
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0073 0.0056 0.099
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0408 0.0571 0.0571
Schistosoma mansoni alpha-1 adrenergic receptor 0.0408 0.0571 0.1006
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0072 0.0055 0.0126
Schistosoma mansoni neuropeptide F-like receptor 0.0408 0.0571 0.1006
Schistosoma mansoni 60S ribosomal protein L21 0.0072 0.0055 0.0095
Loa Loa (eye worm) hypothetical protein 0.0072 0.0055 0.0054
Echinococcus granulosus Tubulin beta 2C chain 0.0306 0.0414 0.0968
Echinococcus granulosus neuropeptides capa receptor 0.0408 0.0571 0.1336
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0072 0.0055 0.1302
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0306 0.0414 0.0968
Schistosoma mansoni vesicular amine transporter 0.0072 0.0055 0.0095
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0072 0.0055 0.0054
Schistosoma mansoni hypothetical protein 0.0408 0.0571 0.1006
Schistosoma mansoni voltage-gated potassium channel 0.0072 0.0055 0.0095
Schistosoma mansoni hypothetical protein 0.0105 0.0105 0.0183
Loa Loa (eye worm) hypothetical protein 0.0072 0.0055 0.0054
Echinococcus granulosus tm gpcr rhodopsin 0.1424 0.2135 0.4997
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Echinococcus granulosus Niemann Pick C1 protein 0.0065 0.0043 0.0099
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0329 0.045 0.0449
Echinococcus multilocularis tubulin subunit beta 0.0306 0.0414 0.0968
Loa Loa (eye worm) hypothetical protein 0.0072 0.0055 0.0054
Brugia malayi Tachykinin-like peptides receptor 99D 0.0408 0.0571 0.0571
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0072 0.0055 0.0126
Brugia malayi neuropeptide F receptor 0.0408 0.0571 0.0571
Trichomonas vaginalis tubulin epsilon chain, putative 0.0306 0.0414 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.1739 0.2621 0.6135
Echinococcus granulosus fmrfamide receptor 0.0408 0.0571 0.1336
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Echinococcus multilocularis hyperpolarization activated cyclic 0.0072 0.0055 0.0126
Schistosoma mansoni biogenic amine receptor 0.0408 0.0571 0.1006
Brugia malayi Endoplasmin precursor 0.0186 0.0229 0.0229
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0408 0.0571 0.0571
Echinococcus granulosus potassium voltage gated channel protein 0.0072 0.0055 0.0126
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0047 0.0016 0.0015
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0408 0.0571 0.1006
Loa Loa (eye worm) adenylyl cyclase 3 0.0372 0.0516 0.0515
Schistosoma mansoni biogenic amine (5HT) receptor 0.0408 0.0571 0.1006
Schistosoma mansoni tubulin subunit beta 0.0306 0.0414 0.0729
Brugia malayi hypothetical protein 0.0408 0.0571 0.0571
Leishmania major beta tubulin 0.0306 0.0414 0.2488
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0693 0.1011 0.2364
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0408 0.0571 0.1006
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0072 0.0055 0.0095
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0072 0.0055 0.1129
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0072 0.0055 0.0054
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0461 0.0653 1
Schistosoma mansoni histamine h1 receptor 0.0408 0.0571 0.1006
Schistosoma mansoni opsin-like receptor 0.0408 0.0571 0.1006
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0408 0.0571 0.1006
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0105 0.0105 0.2514
Trypanosoma cruzi heat shock protein 85, putative 0.0186 0.0229 0.5532
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.0092 0.0084 0.2587
Loa Loa (eye worm) hypothetical protein 0.0062 0.0038 0.0038
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0047 0.0016 0.0015
Loa Loa (eye worm) brahma associated protein 0.0105 0.0105 0.0104
Schistosoma mansoni amine GPCR 0.0408 0.0571 0.1006
Echinococcus granulosus adenylate cyclase 9 0.0291 0.0391 0.0915
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0145 0.0166 0.0291
Schistosoma mansoni tubulin subunit beta 0.0306 0.0414 0.0729
Toxoplasma gondii transporter, cation channel family protein 0.0072 0.0055 0.1302
Echinococcus multilocularis voltage gated potassium channel 0.0072 0.0055 0.0126
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0191 0.0238 0.1961
Leishmania major beta tubulin 0.0306 0.0414 0.2488
Echinococcus granulosus prolyl endopeptidase 0.0145 0.0166 0.0387
Echinococcus granulosus alpha 1A adrenergic receptor 0.0408 0.0571 0.1336
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0055 0.1302
Echinococcus granulosus integrin alpha ps 0.0136 0.0153 0.0357
Loa Loa (eye worm) hypothetical protein 0.0172 0.0208 0.0207
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0054 0.1234
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0037 0.0001 0.0013
Loa Loa (eye worm) hypothetical protein 0.3721 0.5672 0.5671
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Trypanosoma brucei Heat shock protein 83, putative 0.0186 0.0229 0.4026
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0043 0.0841
Brugia malayi G protein-coupled receptor F59B2.13 0.0408 0.0571 0.0571
Echinococcus granulosus calcium activated potassium channel 0.0073 0.0055 0.0128
Leishmania major beta tubulin 0.0306 0.0414 0.2488
Leishmania major heat shock protein 83-1 0.0186 0.0229 0.1376
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0054 0.1127
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0054 0.13
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0408 0.0571 0.1336
Loa Loa (eye worm) hypothetical protein 0.0239 0.0311 0.031
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0054 0.1127
Echinococcus multilocularis voltage dependent calcium channel 0.0072 0.0055 0.0126
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0408 0.0571 0.1336
Loa Loa (eye worm) hypothetical protein 0.0062 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.1739 0.2621 0.4621
Echinococcus multilocularis prolyl endopeptidase 0.0145 0.0166 0.0387
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0072 0.0055 0.0126
Echinococcus granulosus potassium voltage gated channel protein 0.0072 0.0055 0.0126
Chlamydia trachomatis DNA topoisomerase I 0.0105 0.0105 0.5
Schistosoma mansoni hypothetical protein 0.0055 0.0029 0.0049
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0072 0.0055 0.0126
Echinococcus multilocularis conserved hypothetical protein 0.0072 0.0055 0.0126
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0132 0.0131
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0054 0.1127
Plasmodium falciparum membrane associated erythrocyte binding-like protein 0.0068 0.0048 0.1134
Brugia malayi hypothetical protein 0.0408 0.0571 0.0571
Leishmania major heat shock protein 83-1 0.0186 0.0229 0.1376
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.1739 0.2621 0.2621
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0011 0.019
Brugia malayi neuropeptide F receptor 0.0408 0.0571 0.0571
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0073 0.0056 0.0098
Echinococcus multilocularis potassium large conductance calcium activated 0.0072 0.0055 0.0126
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.1116 0.1662 0.3889
Schistosoma mansoni myosin xvIII 0.0408 0.0571 0.1006
Leishmania major beta tubulin 0.0306 0.0414 0.2488
Loa Loa (eye worm) hypothetical protein 0.0443 0.0626 0.0625
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0157 0.0185 0.1109
Toxoplasma gondii beta tubulin 0.0306 0.0414 1
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Brugia malayi heat shock protein 90 0.0186 0.0229 0.0229
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0132 0.0131
Trypanosoma brucei beta tubulin 0.0306 0.0414 0.7268
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0073 0.0056 0.1347
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0066 0.0045 0.0789
Echinococcus multilocularis dna polymerase kappa 0.0044 0.0011 0.0024
Echinococcus granulosus voltage dependent calcium channel 0.0072 0.0055 0.0126
Trichomonas vaginalis AGC family protein kinase 0.0047 0.0016 0.0182
Echinococcus multilocularis ryanodine receptor 44f 0.0072 0.0055 0.0126
Loa Loa (eye worm) tubulin beta-2A chain 0.0306 0.0414 0.0413
Trichomonas vaginalis tubulin gamma chain, putative 0.0306 0.0414 1
Loa Loa (eye worm) calcium channel 0.0072 0.0055 0.0054
Schistosoma mansoni hypothetical protein 0.3721 0.5672 1
Echinococcus multilocularis adenosine deaminase 0.0092 0.0084 0.0195
Leishmania major heat shock protein 83-1 0.0186 0.0229 0.1376
Brugia malayi latrophilin 2 splice variant baaae 0.3721 0.5672 0.5671
Loa Loa (eye worm) hypothetical protein 0.0072 0.0055 0.0054
Echinococcus multilocularis rhodopsin orphan GPCR 0.0408 0.0571 0.1336
Echinococcus multilocularis heat shock protein 90 0.0165 0.0197 0.0459
Schistosoma mansoni voltage-gated potassium channel 0.0072 0.0055 0.0095
Echinococcus granulosus orexin receptor type 2 0.0408 0.0571 0.1336
Brugia malayi hypothetical protein 0.0443 0.0626 0.0625
Loa Loa (eye worm) beta-tubulin 0.0306 0.0414 0.0413
Echinococcus granulosus rhodopsin orphan GPCR 0.0408 0.0571 0.1336
Leishmania major beta tubulin 0.0306 0.0414 0.2488
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0054 0.0156
Echinococcus granulosus hyperpolarization activated cyclic 0.0072 0.0055 0.0126
Trypanosoma cruzi Heat shock protein 83, putative 0.0186 0.0229 0.5532
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0072 0.0055 0.0054
Leishmania major heat shock protein 83-1 0.0186 0.0229 0.1376
Echinococcus multilocularis neuropeptide receptor 0.0868 0.1279 0.2993
Mycobacterium ulcerans beta-lactamase 0.0072 0.0054 0.1234
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0157 0.0185 0.4459
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0072 0.0055 0.0095
Trichomonas vaginalis heat shock protein, putative 0.0064 0.0041 0.0802
Schistosoma mansoni voltage-gated potassium channel 0.0072 0.0055 0.0095
Giardia lamblia Heat shock protein HSP 90-alpha 0.0186 0.0229 0.5492
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0072 0.0055 0.0126
Brugia malayi Transient-receptor-potential like protein 0.0072 0.0055 0.0054
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0072 0.0055 0.0126
Loa Loa (eye worm) hypothetical protein 0.0168 0.0202 0.0201
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0072 0.0055 0.0126
Plasmodium vivax heat shock protein 86, putative 0.0186 0.0229 0.5443
Loa Loa (eye worm) hypothetical protein 0.0092 0.0084 0.0084
Loa Loa (eye worm) TYRA-2 protein 0.0408 0.0571 0.0571
Trichomonas vaginalis adenosine deaminase, putative 0.0092 0.0084 0.1862
Schistosoma mansoni serine-type protease inhibitor 0.0961 0.1422 0.2507
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0011 0.0244
Echinococcus granulosus potassium voltage gated channel protein 0.0072 0.0055 0.0126
Brugia malayi sulfakinin receptor protein 0.0616 0.0892 0.0891
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0072 0.0055 0.0095
Echinococcus granulosus short transient receptor potential channel 6 0.0072 0.0055 0.0126
Schistosoma mansoni tubulin subunit beta 0.0306 0.0414 0.0729
Echinococcus granulosus heat shock protein 90 0.0186 0.0229 0.0535
Trypanosoma brucei heat shock protein, putative 0.0186 0.0229 0.4026
Loa Loa (eye worm) melatonin receptor type 1A 0.0408 0.0571 0.0571
Echinococcus granulosus neuropeptide receptor A26 0.0408 0.0571 0.1336
Entamoeba histolytica tubulin family protein 0.0306 0.0414 1
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Leishmania major heat shock protein, putative 0.0042 0.0009 0.0048
Leishmania major beta tubulin 0.0306 0.0414 0.2488
Treponema pallidum heat shock protein 90 0.0165 0.0197 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0408 0.0571 0.1336
Toxoplasma gondii ABC1 family protein 0.0072 0.0054 0.13
Echinococcus multilocularis rhodopsin orphan GPCR 0.0408 0.0571 0.1336
Schistosoma mansoni voltage-gated cation channel 0.0072 0.0055 0.0095
Echinococcus multilocularis transient receptor potential gamma protein 0.0072 0.0055 0.0126
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0408 0.0571 0.1006
Schistosoma mansoni ryanodine receptor related 0.0072 0.0055 0.0095
Brugia malayi prolyl oligopeptidase family protein 0.0145 0.0166 0.0165
Echinococcus multilocularis neuropeptide receptor A26 0.0408 0.0571 0.1336
Schistosoma mansoni voltage-gated potassium channel 0.0072 0.0055 0.0095
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0157 0.0185 0.0325
Schistosoma mansoni hypothetical protein 0.0105 0.0105 0.0183
Echinococcus multilocularis Protein lozenge 0.0056 0.0029 0.0066
Brugia malayi Latrophilin receptor protein 2 0.1739 0.2621 0.2621
Echinococcus multilocularis potassium voltage gated channel protein 0.0072 0.0055 0.0126
Mycobacterium ulcerans hypothetical protein 0.0072 0.0054 0.1234
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0072 0.0055 0.0095
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0072 0.0055 0.0126
Toxoplasma gondii apical membrane antigen 1 protein 0.0068 0.0048 0.1134
Schistosoma mansoni hypothetical protein 0.0105 0.0105 0.0183
Echinococcus granulosus rhodopsin orphan GPCR 0.0408 0.0571 0.1336
Loa Loa (eye worm) hypothetical protein 0.0072 0.0055 0.0054
Loa Loa (eye worm) hypothetical protein 0.0072 0.0055 0.0054
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.017 0.0298
Onchocerca volvulus 0.0232 0.03 0.2473
Loa Loa (eye worm) hypothetical protein 0.0072 0.0055 0.0054
Echinococcus granulosus transient receptor potential cation channel 0.0072 0.0055 0.0126
Toxoplasma gondii hypothetical protein 0.0072 0.0055 0.1302
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0408 0.0571 0.0571
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0016 0.0026
Echinococcus granulosus sodium channel protein 0.1116 0.1662 0.3889
Onchocerca volvulus 0.0408 0.0571 0.4717
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0072 0.0055 0.0054
Onchocerca volvulus 0.0408 0.0571 0.4717
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Brugia malayi NNMT/PNMT/TEMT family protein 0.0629 0.0912 0.0911
Schistosoma mansoni voltage-gated potassium channel 0.0072 0.0055 0.0095
Leishmania major heat shock protein 83-1 0.0186 0.0229 0.1376
Trypanosoma cruzi heat shock protein 90, putative 0.0143 0.0164 0.3949
Loa Loa (eye worm) latrophilin receptor protein 2 0.1739 0.2621 0.2621
Echinococcus granulosus transient receptor potential cation channel 0.0072 0.0055 0.0126
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Giardia lamblia Heat shock protein HSP 90-alpha 0.0165 0.0197 0.4698
Loa Loa (eye worm) hypothetical protein 0.0072 0.0054 0.0054
Echinococcus multilocularis GPCR, family 2 0.1739 0.2621 0.6135
Loa Loa (eye worm) hypothetical protein 0.0046 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Trypanosoma cruzi beta tubulin, putative 0.0306 0.0414 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0306 0.0414 0.0968
Echinococcus multilocularis two pore calcium channel protein 2 0.0072 0.0055 0.0126
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0408 0.0571 0.0571
Echinococcus granulosus tubulin beta 1 chain 0.0306 0.0414 0.0968
Echinococcus granulosus two pore calcium channel protein 2 0.0072 0.0055 0.0126
Onchocerca volvulus Adenosine deaminase homolog 0.0092 0.0084 0.069
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0408 0.0571 0.0571
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.001 0.0029
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0072 0.0055 0.0054
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0001 0.0013
Loa Loa (eye worm) runx1 0.0056 0.0029 0.0028
Echinococcus granulosus tm gpcr rhodopsin 0.0408 0.0571 0.1336
Schistosoma mansoni heat shock protein 0.0042 0.0009 0.0014
Brugia malayi hypothetical protein 0.0616 0.0892 0.0891
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0072 0.0055 0.0054
Schistosoma mansoni tubulin subunit beta 0.0306 0.0414 0.0729
Brugia malayi Calcitonin receptor-like protein seb-1 0.546 0.8349 0.8349
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0072 0.0055 0.0054
Giardia lamblia Grp94/Hsp90 0.0165 0.0197 0.4698
Echinococcus multilocularis heat shock protein 0.0186 0.0229 0.0535
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Entamoeba histolytica protein kinase, putative 0.0047 0.0016 0.0287
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0408 0.0571 0.1006
Loa Loa (eye worm) tubulin beta-4 chain 0.0306 0.0414 0.0413
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Echinococcus multilocularis g protein coupled receptor 0.0408 0.0571 0.1336
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.1739 0.2621 0.6135
Trichomonas vaginalis heat shock protein, putative 0.0186 0.0229 0.5443
Echinococcus multilocularis hyperpolarization activated cyclic 0.0072 0.0055 0.0126
Echinococcus multilocularis SWI:SNF matrix associated 0.0105 0.0105 0.0243
Onchocerca volvulus 0.0408 0.0571 0.4717
Entamoeba histolytica heat shock protein 90, putative 0.0186 0.0229 0.5492
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0054 0.13
Echinococcus multilocularis transfer RNA-Gly 0.0072 0.0055 0.0126
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0054 0.0625
Toxoplasma gondii transporter, cation channel family protein 0.0072 0.0055 0.1302
Echinococcus multilocularis heat shock protein 90 0.0186 0.0229 0.0535
Echinococcus multilocularis G protein coupled receptor 139 0.0868 0.1279 0.2993
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0638 0.0926 0.0925
Plasmodium falciparum adenosine deaminase 0.0092 0.0084 0.202
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0055 0.0029 0.0065
Trypanosoma brucei beta tubulin 0.0306 0.0414 0.7268
Mycobacterium ulcerans heat shock protein 90 0.0165 0.0197 0.5261
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0072 0.0055 0.0054
Echinococcus granulosus heat shock protein 90 0.0165 0.0197 0.0459
Trichomonas vaginalis endoplasmin, putative 0.0064 0.0041 0.0802
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0408 0.0571 0.1006
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Schistosoma mansoni voltage-gated potassium channel 0.0072 0.0055 0.0095
Brugia malayi Serotonin receptor 0.0408 0.0571 0.0571
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Brugia malayi hypothetical protein 0.0408 0.0571 0.0571
Loa Loa (eye worm) glutaminase 0.0273 0.0364 0.0364
Leishmania major hypothetical protein, conserved 0.0072 0.0055 0.0324
Echinococcus granulosus sodium leak channel non selective protein 0.0072 0.0055 0.0126
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0047 0.0016 0.0036
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0055 0.1302
Echinococcus multilocularis integrin alpha ps 0.0136 0.0153 0.0357
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0016 0.0035
Loa Loa (eye worm) hypothetical protein 0.0072 0.0055 0.0054
Leishmania major beta tubulin 0.0306 0.0414 0.2488
Echinococcus multilocularis sodium leak channel non selective protein 0.0072 0.0055 0.0126
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0042 0.0009 0.0019
Onchocerca volvulus 0.0291 0.0391 0.3229
Loa Loa (eye worm) hypothetical protein 0.0072 0.0055 0.0054
Echinococcus multilocularis Niemann Pick C1 protein 0.0065 0.0043 0.0099
Brugia malayi MH2 domain containing protein 0.0123 0.0132 0.0131
Brugia malayi brahma associated protein 60 kDa 0.0105 0.0105 0.0104
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0408 0.0571 0.0571
Schistosoma mansoni integrin alpha-ps 0.0071 0.0053 0.0092
Loa Loa (eye worm) G-protein coupled receptor 0.0408 0.0571 0.0571
Brugia malayi beta-lactamase family protein 0.0072 0.0054 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0011 0.019
Trypanosoma brucei oligopeptidase b 0.0066 0.0045 0.0789
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0073 0.0056 0.0335
Echinococcus multilocularis fmrfamide receptor 0.0408 0.0571 0.1336
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0072 0.0055 0.0126
Trichomonas vaginalis AGC family protein kinase 0.0047 0.0016 0.0182
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0105 0.0105 0.0243
Echinococcus granulosus adenylate cyclase type IX 0.0093 0.0087 0.0201
Onchocerca volvulus 0.0105 0.0105 0.0859
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0065 0.0043 0.0074
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.0163 0.0381
Echinococcus granulosus hypothetical protein 0.0072 0.0055 0.0126
Echinococcus granulosus transient receptor potential cation channel 0.0072 0.0055 0.0126
Plasmodium vivax adenosine deaminase, putative 0.0092 0.0084 0.1862
Brugia malayi hypothetical protein 0.0408 0.0571 0.0571
Onchocerca volvulus 0.0408 0.0571 0.4717
Schistosoma mansoni voltage-gated potassium channel 0.0072 0.0055 0.0095
Brugia malayi Integrin alpha pat-2 precursor 0.0304 0.0412 0.0411
Echinococcus multilocularis shaker cognate 0.0072 0.0055 0.0126
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0072 0.0055 0.0095
Toxoplasma gondii beta-1 tubulin, putative 0.0306 0.0414 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0306 0.0414 0.0968
Brugia malayi prolyl oligopeptidase family protein 0.0073 0.0056 0.0056
Plasmodium falciparum endoplasmin, putative 0.0064 0.0041 0.0981
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0072 0.0055 0.0054
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0291 0.0391 0.3229
Loa Loa (eye worm) hypothetical protein 0.0062 0.0038 0.0038
Echinococcus multilocularis beta tubulin 0.0306 0.0414 0.0968
Schistosoma mansoni voltage-dependent calcium channel 0.0072 0.0055 0.0095
Brugia malayi hypothetical protein 0.0408 0.0571 0.0571
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0011 0.019
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0408 0.0571 0.1336
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0157 0.0185 0.0431
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0016 0.0035
Echinococcus granulosus neuropeptides capa receptor 0.0408 0.0571 0.1336
Leishmania major heat shock protein 83-1 0.0186 0.0229 0.1376
Loa Loa (eye worm) voltage-gated potassium channel 0.0072 0.0055 0.0054
Trypanosoma cruzi oligopeptidase b 0.0066 0.0045 0.107
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0072 0.0055 0.0126
Schistosoma mansoni neuropeptide receptor 0.0408 0.0571 0.1006
Brugia malayi ORL1-like opioid receptor 0.0408 0.0571 0.0571
Brugia malayi Adenosine/AMP deaminase family protein 0.0092 0.0084 0.0084
Mycobacterium tuberculosis Conserved protein 0.0072 0.0054 0.0156
Loa Loa (eye worm) hypothetical protein 0.0072 0.0054 0.0054
Echinococcus multilocularis sodium channel protein 0.1116 0.1662 0.3889
Echinococcus granulosus two pore calcium channel protein 1 0.0072 0.0055 0.0126
Leishmania major beta tubulin 0.0306 0.0414 0.2488
Trypanosoma brucei prolyl endopeptidase 0.0145 0.0166 0.2914
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.2812 0.4272 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0072 0.0055 0.0126
Echinococcus granulosus potassium voltage gated channel protein 0.0072 0.0055 0.0126
Onchocerca volvulus 0.0408 0.0571 0.4717
Onchocerca volvulus 0.0408 0.0571 0.4717
Schistosoma mansoni transient receptor potential channel 0.0072 0.0055 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0105 0.2366
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0016 0.0026
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.0629 0.0912 0.0911
Loa Loa (eye worm) BEN-1 protein 0.0306 0.0414 0.0413
Schistosoma mansoni voltage-gated potassium channel 0.0072 0.0055 0.0095
Echinococcus granulosus adenosine deaminase 0.0092 0.0084 0.0195
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0072 0.0055 0.0054
Brugia malayi glutaminase DH11.1 0.0273 0.0364 0.0364
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0072 0.0055 0.0126
Loa Loa (eye worm) hypothetical protein 0.6533 1 1
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.0092 0.0084 0.0646
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0408 0.0571 0.1006
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0165 0.0197 0.1181
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0054 0.0126
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0072 0.0055 0.0126
Brugia malayi prolyl oligopeptidase family protein 0.0191 0.0238 0.0237
Schistosoma mansoni neuropeptide receptor 0.0408 0.0571 0.1006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0408 0.0571 0.1006
Giardia lamblia Beta tubulin 0.0306 0.0414 1
Echinococcus multilocularis neuropeptides capa receptor 0.0408 0.0571 0.1336
Schistosoma mansoni transient receptor potential channel 0.0072 0.0055 0.0095
Giardia lamblia Beta tubulin 0.0306 0.0414 1
Brugia malayi hypothetical protein 0.0046 0.0014 0.0013
Echinococcus granulosus transient receptor potential cation channel 0.0072 0.0055 0.0126
Echinococcus multilocularis Tubulin beta 2C chain 0.0306 0.0414 0.0968
Echinococcus multilocularis neuropeptide s receptor 0.0408 0.0571 0.1336
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0072 0.0055 0.0126
Toxoplasma gondii heat shock protein 75, putative 0.0042 0.0009 0.0195
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Echinococcus multilocularis rhodopsin orphan GPCR 0.0408 0.0571 0.1336
Echinococcus multilocularis integrin alpha ps 0.0065 0.0044 0.0101
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0073 0.0056 0.013
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1424 0.2135 0.4997
Trichomonas vaginalis heat shock protein, putative 0.0165 0.0197 0.4641
Brugia malayi Dopamine receptor 0.0408 0.0571 0.0571
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0066 0.0045 0.107
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0073 0.0056 0.1347
Schistosoma mansoni hypothetical protein 0.0408 0.0571 0.1006
Leishmania major heat shock protein 83-1 0.0186 0.0229 0.1376
Echinococcus multilocularis protein patched 0.0065 0.0043 0.0099
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0072 0.0055 0.0126
Trypanosoma brucei heat shock protein 84, putative 0.0042 0.0009 0.0154
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Echinococcus granulosus GPCR family 2 0.1739 0.2621 0.6135
Loa Loa (eye worm) hypothetical protein 0.0071 0.0053 0.0052
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.2812 0.4272 1
Loa Loa (eye worm) hypothetical protein 0.0823 0.121 0.121
Brugia malayi Serotonin receptor 0.0408 0.0571 0.0571
Schistosoma mansoni integrin alpha 0.0304 0.0412 0.0725
Echinococcus granulosus neuropeptide s receptor 0.0408 0.0571 0.1336
Echinococcus granulosus tubulin beta 4A class IVa 0.0306 0.0414 0.0968
Schistosoma mansoni adenoreceptor 0.0408 0.0571 0.1006
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0092 0.0084 0.202
Echinococcus multilocularis potassium voltage gated channel protein 0.0072 0.0055 0.0126
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0806 0.1185 0.9789
Onchocerca volvulus 0.0408 0.0571 0.4717
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Echinococcus multilocularis g protein coupled receptor 0.0408 0.0571 0.1336
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0072 0.0055 0.0126
Brugia malayi hypothetical protein 0.0408 0.0571 0.0571
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0157 0.0185 0.0184
Echinococcus granulosus rhodopsin orphan GPCR 0.0408 0.0571 0.1336
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0408 0.0571 0.1006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0016 0.0026
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0117 0.0123 0.1287
Schistosoma mansoni biogenic amine (5HT) receptor 0.0408 0.0571 0.1006
Schistosoma mansoni opsin-like receptor 0.0408 0.0571 0.1006
Leishmania major oligopeptidase b 0.0066 0.0045 0.0266
Echinococcus multilocularis serotonin receptor 0.0408 0.0571 0.1336
Toxoplasma gondii beta-tubulin, putative 0.0306 0.0414 1
Schistosoma mansoni apoptosis regulator bax 0.0055 0.0029 0.0049
Trypanosoma brucei heat shock protein 90, putative 0.0186 0.0229 0.4026
Echinococcus granulosus rhodopsin orphan GPCR 0.0408 0.0571 0.1336
Leishmania major beta tubulin 0.0306 0.0414 0.2488
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0072 0.0055 0.0126
Brugia malayi G protein-coupled receptor 0.0408 0.0571 0.0571
Echinococcus multilocularis voltage dependent calcium channel 0.0072 0.0055 0.0126
Echinococcus multilocularis neuropeptide receptor 0.0408 0.0571 0.1336
Echinococcus multilocularis fmrfamide receptor 0.0408 0.0571 0.1336
Schistosoma mansoni voltage-gated potassium channel 0.0072 0.0055 0.0095
Loa Loa (eye worm) hypothetical protein 0.0794 0.1166 0.1165
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0072 0.0055 0.0126
Brugia malayi Dopamine receptor protein 1 0.0408 0.0571 0.0571
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0011 0.0244
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0011 0.0244
Schistosoma mansoni tubulin subunit beta 0.0306 0.0414 0.0729
Loa Loa (eye worm) hypothetical protein 0.0072 0.0054 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0011 0.019
Echinococcus multilocularis two pore calcium channel protein 1 0.0072 0.0055 0.0126
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0074 0.0057 0.1278
Brugia malayi hypothetical protein 0.0408 0.0571 0.0571
Toxoplasma gondii prolyl endopeptidase 0.0145 0.0166 0.3998
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0054 0.0095
Loa Loa (eye worm) hypothetical protein 0.0072 0.0055 0.0054
Schistosoma mansoni voltage-gated ion channel 0.0072 0.0055 0.0095
Leishmania major heat shock protein 83-1 0.0186 0.0229 0.1376
Echinococcus granulosus shaker cognate 0.0072 0.0055 0.0126
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0408 0.0571 0.1336
Echinococcus multilocularis g-protein coupled receptor 0.0408 0.0571 0.1336
Echinococcus granulosus Tubulin beta 2C chain 0.0306 0.0414 0.0968
Loa Loa (eye worm) neuropeptide F receptor 0.0408 0.0571 0.0571
Toxoplasma gondii heat shock protein HSP90 0.0186 0.0229 0.5532
Echinococcus granulosus g protein coupled receptor 0.0408 0.0571 0.1336
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0016 0.0015
Schistosoma mansoni endoplasmin 0.0186 0.0229 0.0403
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0072 0.0055 0.0957
Echinococcus multilocularis serotonin receptor 0.0408 0.0571 0.1336
Schistosoma mansoni tubulin subunit beta 0.0306 0.0414 0.0729
Schistosoma mansoni heat shock protein 0.0186 0.0229 0.0403
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0165 0.0197 0.0459
Echinococcus multilocularis integrin alpha 3 0.0233 0.0302 0.0706
Brugia malayi RE15519p 0.0408 0.0571 0.0571
Plasmodium falciparum heat shock protein 90 0.0186 0.0229 0.5532
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.001 0.0223
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0408 0.0571 0.1006
Echinococcus granulosus potassium voltage gated channel protein 0.0072 0.0055 0.0126
Loa Loa (eye worm) G-protein coupled receptor 0.0408 0.0571 0.0571
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0074 0.0057 0.1184
Echinococcus multilocularis allatostatin A receptor 0.0823 0.121 0.2832
Echinococcus multilocularis dro:myosuppressin receptor 0.0408 0.0571 0.1336
Echinococcus granulosus serotonin receptor 0.0408 0.0571 0.1336
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0072 0.0055 0.0126
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0408 0.0571 0.1006
Brugia malayi ion channel NompC 0.0072 0.0055 0.0054
Brugia malayi larval opioid receptor 0.0408 0.0571 0.0571
Trichomonas vaginalis heat shock protein, putative 0.0165 0.0197 0.4641
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0072 0.0055 0.0054
Schistosoma mansoni transient receptor potential channel 0.0072 0.0055 0.0095
Mycobacterium ulcerans glutaminase 0.0273 0.0364 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0408 0.0571 0.1336
Echinococcus granulosus allatostatin A receptor 0.0823 0.121 0.2832
Brugia malayi Caveolin-1 0.0575 0.0829 0.0829
Trypanosoma brucei prolyl oligopeptidase, putative 0.0066 0.0045 0.0789
Echinococcus multilocularis rhodopsin orphan GPCR 0.0408 0.0571 0.1336
Entamoeba histolytica adenosine deaminase, putative 0.0092 0.0084 0.1949
Leishmania major beta tubulin 0.0306 0.0414 0.2488
Trypanosoma brucei heat shock protein, putative 0.0186 0.0229 0.4026
Loa Loa (eye worm) hypothetical protein 0.0616 0.0892 0.0891
Echinococcus granulosus transient receptor potential gamma protein 0.0072 0.0055 0.0126
Echinococcus granulosus integrin alpha 3 0.0233 0.0302 0.0706
Plasmodium vivax apical membrane antigen 1 0.0287 0.0385 0.9275
Brugia malayi Hsp90 protein 0.0042 0.0009 0.0008
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0165 0.0197 0.5
Schistosoma mansoni hypothetical protein 0.0407 0.057 0.1003
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Onchocerca volvulus 0.0408 0.0571 0.4717
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0408 0.0571 0.1336
Loa Loa (eye worm) hypothetical protein 0.0072 0.0055 0.0054
Schistosoma mansoni hypothetical protein 0.0065 0.0044 0.0076
Schistosoma mansoni voltage-gated potassium channel 0.0072 0.0055 0.0095
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0072 0.0055 0.0445
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0055 0.0029 0.0065
Loa Loa (eye worm) endoplasmin 0.0186 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Trichomonas vaginalis esterase, putative 0.0072 0.0054 0.1127
Onchocerca volvulus 0.0279 0.0372 0.3072
Schistosoma mansoni transient receptor potential channel 4 0.0072 0.0055 0.0095
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0072 0.0055 0.0054
Leishmania major beta tubulin 0.0306 0.0414 0.2488
Toxoplasma gondii apical membrane antigen 1 domain-containing protein 0.0287 0.0385 0.9289
Plasmodium falciparum apical membrane antigen 1 0.0287 0.0385 0.9289
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0072 0.0055 0.0095
Mycobacterium tuberculosis Conserved protein 0.0072 0.0054 0.0156
Loa Loa (eye worm) tubulin beta-1 chain 0.0306 0.0414 0.0413
Echinococcus multilocularis transient receptor potential cation channel 0.0072 0.0055 0.0126
Loa Loa (eye worm) hypothetical protein 0.0072 0.0055 0.0054
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0408 0.0571 0.1006
Onchocerca volvulus 0.0072 0.0054 0.0444
Brugia malayi hypothetical protein 0.0408 0.0571 0.0571
Echinococcus granulosus neuropeptide Y receptor 0.0408 0.0571 0.1336
Echinococcus multilocularis SWI:SNF matrix associated 0.0105 0.0105 0.0243
Toxoplasma gondii heat shock protein 90, putative 0.0186 0.0229 0.5532
Loa Loa (eye worm) hypothetical protein 0.0072 0.0054 0.0054
Schistosoma mansoni two-pore calcium channel 0.0072 0.0055 0.0095
Echinococcus multilocularis potassium voltage gated channel protein 0.0072 0.0055 0.0126
Schistosoma mansoni serine-type protease inhibitor 0.0961 0.1422 0.2507
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0016 0.0027
Onchocerca volvulus 0.0408 0.0571 0.4717
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Loa Loa (eye worm) hypothetical protein 0.0062 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0072 0.0055 0.0054
Loa Loa (eye worm) prolyl oligopeptidase 0.0191 0.0238 0.0237
Echinococcus granulosus biogenic amine 5HT receptor 0.0408 0.0571 0.1336
Brugia malayi hypothetical protein 0.0072 0.0055 0.0054
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0072 0.0055 0.0126
Schistosoma mansoni voltage-gated potassium channel 0.0072 0.0055 0.0095
Trypanosoma brucei heat shock protein, putative 0.0186 0.0229 0.4026
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0072 0.0055 0.1129
Leishmania major beta tubulin 0.0306 0.0414 0.2488
Schistosoma mansoni neuropeptide receptor 0.0408 0.0571 0.1006
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0073 0.0056 0.1347
Echinococcus granulosus Dipeptidyl peptidase 9 0.0073 0.0056 0.013
Echinococcus granulosus beta tubulin 0.0306 0.0414 0.0968
Leishmania major adenine aminohydrolase 0.0092 0.0084 0.0503
Echinococcus granulosus neuropeptide FF receptor 2 0.0408 0.0571 0.1336
Echinococcus multilocularis beta tubulin 0.0306 0.0414 0.0968
Schistosoma mansoni amine GPCR 0.0408 0.0571 0.1006
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0408 0.0571 0.0571
Brugia malayi Integrin alpha cytoplasmic region family protein 0.023 0.0298 0.0297
Echinococcus granulosus heat shock protein 0.0186 0.0229 0.0535
Schistosoma mansoni hypothetical protein 0.0055 0.0029 0.0049
Echinococcus granulosus neuropeptide receptor 0.0868 0.1279 0.2993
Trypanosoma cruzi heat shock protein 85, putative 0.0165 0.0197 0.4745
Echinococcus multilocularis short transient receptor potential channel 6 0.0072 0.0055 0.0126
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0072 0.0055 0.0095
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0408 0.0571 0.1006
Schistosoma mansoni neuropeptide F-like receptor 0.0408 0.0571 0.1006
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0072 0.0055 0.0126
Echinococcus multilocularis calcium activated potassium channel 0.0073 0.0055 0.0128
Echinococcus granulosus Tubulin beta 2C chain 0.0306 0.0414 0.0968
Echinococcus granulosus dna polymerase kappa 0.0044 0.0011 0.0024
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0054 0.0156
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0044 0.0011 0.0051
Leishmania major beta tubulin 0.0306 0.0414 0.2488
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0011 0.0244
Echinococcus multilocularis sex peptide receptor 0.0408 0.0571 0.1336
Loa Loa (eye worm) heat shock protein 90 0.0186 0.0229 0.0229
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0408 0.0571 0.1336
Trichomonas vaginalis adenosine deaminase, putative 0.0092 0.0084 0.1862
Echinococcus multilocularis integrin alpha ps 0.0136 0.0153 0.0357
Schistosoma mansoni hypothetical protein 0.0072 0.0055 0.0095
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0054 0.0156
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0408 0.0571 0.1336
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.001 0.0029
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0408 0.0571 0.1336
Trypanosoma brucei heat shock protein, putative 0.0186 0.0229 0.4026
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0072 0.0055 0.0054
Brugia malayi cation channel family protein 0.0072 0.0055 0.0054
Echinococcus granulosus sex peptide receptor 0.0408 0.0571 0.1336
Loa Loa (eye worm) hypothetical protein 0.0072 0.0055 0.0054
Loa Loa (eye worm) apoptosis regulator protein 0.0055 0.0029 0.0028
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0408 0.0571 0.1336
Echinococcus multilocularis short transient receptor potential channel 6 0.0072 0.0055 0.0126
Schistosoma mansoni hypothetical protein 0.1739 0.2621 0.4621
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0001 0.0013
Loa Loa (eye worm) heat shock protein 75 0.0042 0.0009 0.0008
Mycobacterium tuberculosis Conserved protein 0.0072 0.0054 0.0156
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0072 0.0055 0.0095
Plasmodium vivax tubulin beta chain, putative 0.0306 0.0414 1
Onchocerca volvulus 0.0823 0.121 1
Schistosoma mansoni voltage-gated potassium channel 0.0072 0.0055 0.0095
Plasmodium falciparum tubulin beta chain 0.0306 0.0414 1
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0105 0.0105 0.2366
Leishmania major hypothetical protein, unknown function 0.0072 0.0055 0.0324
Brugia malayi beta-lactamase family protein 0.0072 0.0054 0.0054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0408 0.0571 0.1006
Echinococcus granulosus biogenic amine 5HT receptor 0.0408 0.0571 0.1336
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0072 0.0055 0.0095
Trichomonas vaginalis tubulin, putative 0.0306 0.0414 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0408 0.0571 0.0571
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0072 0.0055 0.0445
Leishmania major beta tubulin 0.0306 0.0414 0.2488
Loa Loa (eye worm) hypothetical protein 0.0291 0.0391 0.0391
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0074 0.0057 0.1184
Echinococcus granulosus potassium large conductance calcium activated 0.0072 0.0055 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0011 0.019
Trypanosoma brucei RNA helicase, putative 0.0407 0.057 1
Mycobacterium ulcerans lipase LipD 0.0072 0.0054 0.1234
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0408 0.0571 0.1336
Loa Loa (eye worm) tubulin beta chain 0.0306 0.0414 0.0413
Entamoeba histolytica tubulin family protein 0.0306 0.0414 1
Onchocerca volvulus Prolyl endopeptidase homolog 0.0145 0.0166 0.1366
Leishmania major heat shock protein 83-1 0.0186 0.0229 0.1376
Loa Loa (eye worm) hypothetical protein 0.023 0.0298 0.0297
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0066 0.0045 0.0965
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0105 0.0105 0.2514
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0054 0.1127
Schistosoma mansoni endoplasmin 0.0186 0.0229 0.0403
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0408 0.0571 0.1336
Trichomonas vaginalis tubulin epsilon chain, putative 0.0306 0.0414 1
Brugia malayi beta-tubulin, identical 0.0306 0.0414 0.0413
Echinococcus granulosus Solute carrier family 22 5 0.2125 0.3215 0.7525
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0072 0.0055 0.0054
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0072 0.0055 0.0095
Echinococcus granulosus Protein patched homolog 1 0.0065 0.0043 0.0099
Leishmania major heat shock protein 83-1 0.0186 0.0229 0.1376
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0047 0.0016 0.0036
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0054 0.0156
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0054 0.0095
Echinococcus granulosus dro:myosuppressin receptor 0.0408 0.0571 0.1336
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0072 0.0055 0.0126
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0092 0.0084 0.202
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.001 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0011 0.019
Trypanosoma cruzi heat shock protein 85, putative 0.0186 0.0229 0.5532
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0072 0.0055 0.0126
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0066 0.0045 0.107
Plasmodium falciparum heat shock protein 90, putative 0.0042 0.0009 0.0195
Schistosoma mansoni glutaminase 0.0273 0.0364 0.0641
Schistosoma mansoni heat shock protein 0.0186 0.0229 0.0403
Leishmania major beta tubulin 0.0306 0.0414 0.2488
Brugia malayi follicle stimulating hormone receptor 0.0638 0.0926 0.0925
Echinococcus granulosus 7TM GPCR rhodopsin 0.0408 0.0571 0.1336
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0016 0.0015
Echinococcus granulosus SWI:SNF matrix associated 0.0105 0.0105 0.0243
Trichomonas vaginalis DNA polymerase eta, putative 0.0044 0.0011 0.0051
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0408 0.0571 0.1336
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0072 0.0055 0.0095
Onchocerca volvulus 0.0408 0.0571 0.4717
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.001 0.0022
Loa Loa (eye worm) integrin alpha pat-2 0.0469 0.0665 0.0665
Brugia malayi olfactory channel protein osm-9 0.0072 0.0055 0.0054
Schistosoma mansoni amine GPCR 0.0408 0.0571 0.1006
Loa Loa (eye worm) hypothetical protein 0.0072 0.0055 0.0054
Toxoplasma gondii transporter, cation channel family protein 0.0072 0.0055 0.1302
Leishmania major heat shock protein 83-1 0.0186 0.0229 0.1376
Loa Loa (eye worm) BEN-1 protein 0.0306 0.0414 0.0413
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0072 0.0055 0.1302
Schistosoma mansoni amine GPCR 0.0408 0.0571 0.1006
Onchocerca volvulus 0.0408 0.0571 0.4717
Loa Loa (eye worm) hypothetical protein 0.0055 0.0029 0.0028
Brugia malayi Dopamine receptor protein 2 0.0408 0.0571 0.0571
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0016 0.0035
Onchocerca volvulus 0.0072 0.0055 0.0445
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0042 0.0009 0.0066
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0011 0.019
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0072 0.0055 0.0126
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0408 0.0571 0.1336
Echinococcus granulosus transient receptor potential cation channel 0.0072 0.0055 0.0126
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0157 0.0185 0.3248
Schistosoma mansoni biogenic amine receptor 0.0408 0.0571 0.1006
Loa Loa (eye worm) ryanodine receptor 0.0072 0.0055 0.0054
Echinococcus multilocularis transient receptor potential cation channel 0.0072 0.0055 0.0126
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0011 0.019
Loa Loa (eye worm) hypothetical protein 0.0072 0.0055 0.0054
Schistosoma mansoni growth hormone secretagogue receptor 0.0408 0.0571 0.1006
Brugia malayi AKH receptor 0.0408 0.0571 0.0571
Leishmania major heat shock protein 83-1 0.0186 0.0229 0.1376
Plasmodium vivax merozoite adhesive erythrocytic binding protein 0.0068 0.0048 0.0958
Schistosoma mansoni lozenge 0.0056 0.0029 0.005
Echinococcus granulosus 7tm_1 domain containing protein 0.0408 0.0571 0.1336
Schistosoma mansoni adenosine deaminase 0.0092 0.0084 0.0147
Trypanosoma cruzi heat shock protein 85, putative 0.0186 0.0229 0.5532
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0072 0.0055 0.0095
Loa Loa (eye worm) hypothetical protein 0.0072 0.0055 0.0054
Echinococcus multilocularis neuropeptides capa receptor 0.0408 0.0571 0.1336
Loa Loa (eye worm) neuropeptide F receptor 0.0408 0.0571 0.0571
Leishmania major calcium channel protein, putative,ion transporter, putative 0.1116 0.1662 1
Plasmodium falciparum heat shock protein 90, putative 0.0042 0.0009 0.0195
Echinococcus granulosus transient receptor potential cation channel 0.0072 0.0055 0.0126
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0054 0.1127
Echinococcus granulosus voltage gated hydrogen channel 1 0.0072 0.0055 0.0126
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Loa Loa (eye worm) hypothetical protein 0.0072 0.0054 0.0054
Echinococcus granulosus tubulin subunit beta 0.0306 0.0414 0.0968
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0065 0.0043 0.0042
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0157 0.0185 0.4459
Brugia malayi Cyclic-nucleotide gated cation channel 0.0072 0.0055 0.0054
Echinococcus granulosus g protein coupled receptor 0.0408 0.0571 0.1336
Leishmania major beta tubulin 0.0306 0.0414 0.2488
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0072 0.0055 0.0095
Echinococcus multilocularis transient receptor potential cation channel 0.0072 0.0055 0.0126
Loa Loa (eye worm) hypothetical protein 0.0575 0.0829 0.0829
Onchocerca volvulus 0.0443 0.0626 0.5165
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0408 0.0571 0.1336
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0408 0.0571 0.1006
Loa Loa (eye worm) ion channel NompC 0.0072 0.0055 0.0054
Loa Loa (eye worm) hypothetical protein 0.0072 0.0055 0.0054
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0055 0.0029 0.0028
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0072 0.0055 0.0957
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0157 0.0185 0.4927
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0074 0.0057 0.1184
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0072 0.0055 0.0126
Brugia malayi beta-lactamase 0.0072 0.0054 0.0054
Echinococcus granulosus G protein coupled receptor 139 0.0408 0.0571 0.1336
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Loa Loa (eye worm) hypothetical protein 0.0072 0.0055 0.0054
Leishmania major heat shock protein 83-1 0.0186 0.0229 0.1376
Schistosoma mansoni brg-1 associated factor 0.0105 0.0105 0.0183
Echinococcus granulosus tachykinin peptides receptor 99D 0.0408 0.0571 0.1336
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0072 0.0055 0.0126
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0054 0.0956
Echinococcus multilocularis transient receptor potential cation channel 0.0072 0.0055 0.0126
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0066 0.0045 0.0266
Trypanosoma cruzi heat shock protein, putative 0.0042 0.0009 0.0195
Echinococcus multilocularis transient receptor potential cation channel 0.0072 0.0055 0.0126
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0037 0.0001 0.0013
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0408 0.0571 0.1006
Echinococcus multilocularis neuropeptide Y receptor 0.0408 0.0571 0.1336
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0408 0.0571 0.1006
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0072 0.0055 0.0095
Onchocerca volvulus 0.0408 0.0571 0.4717
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.017 0.0396
Echinococcus granulosus rhodopsin orphan GPCR 0.0408 0.0571 0.1336
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0408 0.0571 0.4717
Brugia malayi cation channel family protein 0.0072 0.0055 0.0054
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0072 0.0055 0.0054
Leishmania major hypothetical protein, conserved 0.0072 0.0054 0.0323
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0105 0.0105 0.2514
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0408 0.0571 0.1336
Brugia malayi brahma associated protein 60 kDa 0.0105 0.0105 0.0104
Echinococcus multilocularis SWI:SNF matrix associated 0.0105 0.0105 0.0243
Toxoplasma gondii apical membrane antigen AMA1 0.0068 0.0048 0.1134
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0191 0.0238 0.0555
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0072 0.0055 0.0126
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0072 0.0055 0.0126
Brugia malayi GnHR receptor homolog 0.3672 0.5597 0.5596
Trichomonas vaginalis tubulin alpha chain, putative 0.0306 0.0414 1
Trypanosoma brucei beta tubulin 0.0306 0.0414 0.7268
Brugia malayi SWIB/MDM2 domain containing protein 0.0105 0.0105 0.0104
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0042 0.0009 0.0107
Schistosoma mansoni hypothetical protein 0.1739 0.2621 0.4621
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0072 0.0055 0.0095
Echinococcus granulosus Tubulin beta 2C chain 0.0306 0.0414 0.0968
Entamoeba histolytica heat shock protein 90, putative 0.0186 0.0229 0.5492
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0408 0.0571 0.1006
Trypanosoma cruzi prolyl endopeptidase 0.0145 0.0166 0.3998
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0072 0.0055 0.0054
Schistosoma mansoni voltage-gated potassium channel 0.0072 0.0055 0.0095
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0157 0.0185 0.0431
Echinococcus granulosus g protein coupled receptor 0.0408 0.0571 0.1336
Schistosoma mansoni voltage-gated potassium channel 0.0072 0.0055 0.0095
Trypanosoma brucei heat shock protein, putative 0.0186 0.0229 0.4026
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0072 0.0055 0.0095
Leishmania major heat shock protein 83-1 0.0186 0.0229 0.1376
Trypanosoma brucei heat shock protein, putative 0.0186 0.0229 0.4026
Brugia malayi Pre-SET motif family protein 0.0203 0.0257 0.0256
Echinococcus multilocularis tubulin beta 1 chain 0.0306 0.0414 0.0968
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Echinococcus multilocularis rhodopsin orphan GPCR 0.0408 0.0571 0.1336
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0054 0.1234
Trypanosoma brucei heat shock protein, putative 0.0186 0.0229 0.4026
Loa Loa (eye worm) hypothetical protein 0.0065 0.0044 0.0043
Brugia malayi Adenylyl cyclase protein 0.0291 0.0391 0.0391
Trypanosoma cruzi oligopeptidase b 0.0066 0.0045 0.107
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0072 0.0055 0.0054
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0257 0.0256
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Brugia malayi G-protein coupled receptor 0.0408 0.0571 0.0571
Brugia malayi Tubulin beta-1 chain 0.0306 0.0414 0.0413
Echinococcus granulosus voltage dependent calcium channel 0.0072 0.0055 0.0126
Leishmania major beta tubulin 0.0306 0.0414 0.2488
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0165 0.0197 1
Trypanosoma brucei heat shock protein 90, putative 0.0186 0.0229 0.4026
Echinococcus multilocularis adenylate cyclase type IX 0.0093 0.0087 0.0201
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0054 0.0054
Loa Loa (eye worm) acetyltransferase 0.0147 0.017 0.0169
Entamoeba histolytica adenosine deaminase, putative 0.0092 0.0084 0.1949
Leishmania major heat shock protein 83-1 0.0186 0.0229 0.1376
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0011 0.019
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0105 0.0105 0.0243
Loa Loa (eye worm) hypothetical protein 0.0443 0.0626 0.0625
Loa Loa (eye worm) voltage-gated calcium channel 0.0072 0.0055 0.0054
Onchocerca volvulus 0.0072 0.0054 0.0444
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Echinococcus granulosus TRP transient receptor potential channel 0.0072 0.0055 0.0126
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0408 0.0571 0.1336
Loa Loa (eye worm) pigment dispersing factor receptor c 0.546 0.8349 0.8349
Schistosoma mansoni neuropeptide receptor 0.0868 0.1279 0.2255
Echinococcus multilocularis g protein coupled receptor 0.0408 0.0571 0.1336
Brugia malayi Angiotensin-converting enzyme family protein 0.0329 0.045 0.0449
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0823 0.121 0.2133
Onchocerca volvulus 0.0408 0.0571 0.4717
Loa Loa (eye worm) hypothetical protein 0.0629 0.0912 0.0911
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.001 0.0029
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0054 0.0156
Echinococcus granulosus beta tubulin 0.0306 0.0414 0.0968
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0072 0.0055 0.0054
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0408 0.0571 0.1006
Schistosoma mansoni voltage-gated potassium channel 0.0072 0.0055 0.0095
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0054 0.0054
Brugia malayi putative neuropeptide receptor NPR1 0.0408 0.0571 0.0571
Echinococcus granulosus integrin alpha ps 0.0065 0.0044 0.0101
Echinococcus granulosus sterol regulatory element binding protein 0.0065 0.0043 0.0099
Onchocerca volvulus 0.0408 0.0571 0.4717
Loa Loa (eye worm) voltage-gated potassium channel 0.0072 0.0055 0.0054
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0145 0.0166 0.0291
Trypanosoma cruzi heat shock protein 90, putative 0.0165 0.0197 0.4745
Echinococcus multilocularis Tubulin beta 2C chain 0.0306 0.0414 0.0968
Schistosoma mansoni hypothetical protein 0.0408 0.0571 0.1006
Brugia malayi putative neuropeptide receptor 0.0408 0.0571 0.0571
Schistosoma mansoni hypothetical protein 0.0055 0.0029 0.0049
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0011 0.019
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.017 0.0169
Schistosoma mansoni voltage-gated potassium channel 0.0072 0.0055 0.0095
Loa Loa (eye worm) hypothetical protein 0.0072 0.0055 0.0054
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0693 0.1011 0.2364
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0072 0.0055 0.0126
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0105 0.0105 0.2514
Trichomonas vaginalis tubulin beta chain, putative 0.0306 0.0414 1
Trypanosoma cruzi heat shock protein 90, putative 0.0186 0.0229 0.5532
Onchocerca volvulus Neuropeptide F receptor homolog 0.0408 0.0571 0.4717
Loa Loa (eye worm) voltage-dependent calcium channel 0.0072 0.0055 0.0054
Echinococcus multilocularis potassium voltage gated channel protein 0.0072 0.0055 0.0126
Loa Loa (eye worm) hypothetical protein 0.0072 0.0054 0.0054
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0072 0.0055 0.0095
Trichomonas vaginalis set domain proteins, putative 0.0232 0.03 0.7183
Schistosoma mansoni patched 1 0.0065 0.0043 0.0074
Brugia malayi G-protein coupled receptor 0.0408 0.0571 0.0571
Brugia malayi voltage-dependent calcium channel 0.0072 0.0055 0.0054
Mycobacterium ulcerans adenosine deaminase 0.0092 0.0084 0.2076
Loa Loa (eye worm) hypothetical protein 0.0629 0.0912 0.0911
Brugia malayi Protein kinase domain containing protein 0.0047 0.0016 0.0015
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0073 0.0056 0.099
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0408 0.0571 0.0571
Echinococcus granulosus neuropeptide Y receptor 0.0408 0.0571 0.1336
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0016 0.0035
Chlamydia trachomatis SWIB complex protein 0.0105 0.0105 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0408 0.0571 0.1336
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0408 0.0571 0.1006
Loa Loa (eye worm) glutaminase 2 0.0273 0.0364 0.0364
Echinococcus multilocularis protein dispatched 1 0.0065 0.0043 0.0099
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0408 0.0571 0.1336
Echinococcus multilocularis somatostatin receptor 0.0408 0.0571 0.1336
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0072 0.0055 0.0126
Echinococcus granulosus voltage gated potassium channel 0.0072 0.0055 0.0126
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0408 0.0571 0.1006
Echinococcus granulosus endoplasmin 0.0165 0.0197 0.0459
Loa Loa (eye worm) hypothetical protein 0.0072 0.0055 0.0054
Echinococcus multilocularis orexin receptor type 2 0.0408 0.0571 0.1336
Echinococcus granulosus short transient receptor potential channel 6 0.0072 0.0055 0.0126
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Brugia malayi hypothetical protein 0.0408 0.0571 0.0571
Schistosoma mansoni opsin-like receptor 0.0408 0.0571 0.1006
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0145 0.0166 0.0995
Echinococcus multilocularis adenylate cyclase 9 0.0291 0.0391 0.0915
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0072 0.0055 0.0126
Toxoplasma gondii Hsp90 domain-containing protein 0.0042 0.0009 0.0195
Trichomonas vaginalis glutaminase, putative 0.0273 0.0364 0.8775
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0072 0.0055 0.0126
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Echinococcus granulosus neuropeptide receptor 0.0408 0.0571 0.1336
Leishmania major heat shock protein 83-1 0.0186 0.0229 0.1376
Loa Loa (eye worm) hypothetical protein 0.0157 0.0185 0.0184
Echinococcus multilocularis rhodopsin orphan GPCR 0.0408 0.0571 0.1336
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0105 0.0105 0.0104
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0072 0.0055 0.0126
Echinococcus granulosus ryanodine receptor 44f 0.0072 0.0055 0.0126
Schistosoma mansoni voltage-gated potassium channel 0.0072 0.0055 0.0095
Leishmania major heat shock protein 83-1 0.0186 0.0229 0.1376
Loa Loa (eye worm) beta-lactamase 0.0072 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.1739 0.2621 0.4621
Loa Loa (eye worm) hypothetical protein 0.0145 0.0166 0.0165
Echinococcus granulosus Tubulin beta 2C chain 0.0306 0.0414 0.0968
Echinococcus multilocularis Tubulin beta 2C chain 0.0306 0.0414 0.0968
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0191 0.0238 0.0555
Schistosoma mansoni amine GPCR 0.0408 0.0571 0.1006
Schistosoma mansoni hypothetical protein 0.0408 0.0571 0.1006
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0042 0.0009 0.0019
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0054 0.0156
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0004 0.0088
Plasmodium falciparum membrane associated erythrocyte binding-like protein 0.0068 0.0048 0.1134
Trypanosoma brucei beta tubulin 0.0306 0.0414 0.7268
Echinococcus multilocularis voltage gated potassium channel 0.0072 0.0055 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0011 0.019
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0072 0.0055 0.0126
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0191 0.0238 0.0418
Loa Loa (eye worm) hypothetical protein 0.0072 0.0055 0.0054
Echinococcus granulosus voltage gated potassium channel 0.0072 0.0055 0.0126
Schistosoma mansoni voltage-gated potassium channel 0.0072 0.0055 0.0095
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0055 0.0029 0.0049
Trypanosoma brucei heat shock protein, putative 0.0186 0.0229 0.4026
Loa Loa (eye worm) hypothetical protein 0.0065 0.0043 0.0042
Echinococcus multilocularis sterol regulatory element binding protein 0.0065 0.0043 0.0099
Echinococcus multilocularis rhodopsin orphan GPCR 0.0408 0.0571 0.1336
Echinococcus multilocularis endoplasmin 0.0165 0.0197 0.0459
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0165 0.0197 0.2498
Schistosoma mansoni integrin alpha-ps 0.0136 0.0153 0.0269
Mycobacterium leprae Probable lipase LipE 0.0072 0.0054 0.0625
Plasmodium vivax hypothetical protein, conserved 0.0105 0.0105 0.2366
Echinococcus granulosus hypothetical protein 0.0408 0.0571 0.1336
Brugia malayi CHE-14 protein 0.0065 0.0043 0.0042
Onchocerca volvulus 0.0408 0.0571 0.4717
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0054 0.0126
Echinococcus multilocularis rhodopsin orphan GPCR 0.0408 0.0571 0.1336
Echinococcus multilocularis neuropeptide Y receptor 0.0408 0.0571 0.1336
Leishmania major beta tubulin 0.0306 0.0414 0.2488
Echinococcus multilocularis transient receptor potential cation channel 0.0072 0.0055 0.0126
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0054 0.1127
Loa Loa (eye worm) hypothetical protein 0.0408 0.0571 0.0571
Trichomonas vaginalis heat shock protein, putative 0.0165 0.0197 0.4641
Toxoplasma gondii hypothetical protein 0.0072 0.0055 0.1302
Giardia lamblia Beta tubulin 0.0306 0.0414 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0408 0.0571 0.1006
Loa Loa (eye worm) hypothetical protein 0.1739 0.2621 0.2621
Plasmodium vivax endoplasmin, putative 0.0186 0.0229 0.5443
Echinococcus granulosus rhodopsin orphan GPCR 0.0408 0.0571 0.1336
Brugia malayi Protein kinase domain containing protein 0.0172 0.0209 0.0208
Brugia malayi Melatonin receptor type 1A 0.0408 0.0571 0.0571
Echinococcus granulosus g-protein coupled receptor 0.0408 0.0571 0.1336
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0408 0.0571 0.1336

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 56 % Inhibition of BACE1 (unknown origin) at 10 uM by FRET assay ChEMBL. 18162398
Inhibition (binding) = 56 % Inhibition of BACE1 (unknown origin) at 10 uM by FRET assay ChEMBL. 18162398
Ratio IC50 (binding) < 2 Selectivity for BACE1 (unknown origin) over BACE2 (unknown origin) ChEMBL. 18162398
Ratio IC50 (binding) > 50 Selectivity for BACE1 (unknown origin) over cathepsin D (unknown origin) ChEMBL. 18162398

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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