Detailed information for compound 511974

Basic information

Technical information
  • TDR Targets ID: 511974
  • Name: (2S)-2-[[[(2S)-1-[(2S)-2-acetamido-3-phenylpr opanoyl]pyrrolidin-2-yl]-hydroxyphosphoryl]me thyl]-3-phenylpropanoic acid
  • MW: 486.497 | Formula: C25H31N2O6P
  • H donors: 3 H acceptors: 6 LogP: 1.86 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)N[C@H](C(=O)N1CCC[C@@H]1P(=O)(C[C@H](C(=O)O)Cc1ccccc1)O)Cc1ccccc1
  • InChi: 1S/C25H31N2O6P/c1-18(28)26-22(16-20-11-6-3-7-12-20)24(29)27-14-8-13-23(27)34(32,33)17-21(25(30)31)15-19-9-4-2-5-10-19/h2-7,9-12,21-23H,8,13-17H2,1H3,(H,26,28)(H,30,31)(H,32,33)/t21-,22+,23+/m1/s1
  • InChiKey: IZCQEHKGYUNUAF-VJBWXMMDSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-[[[(2S)-1-[(2S)-2-acetamido-3-phenyl-propanoyl]pyrrolidin-2-yl]-hydroxy-phosphoryl]methyl]-3-phenyl-propanoic acid
  • (2S)-2-[[[(2S)-1-[(2S)-2-acetamido-1-oxo-3-phenylpropyl]-2-pyrrolidinyl]-hydroxyphosphoryl]methyl]-3-phenylpropanoic acid
  • (2S)-2-[[[(2S)-1-[(2S)-2-acetamido-3-phenyl-propanoyl]pyrrolidin-2-yl]-hydroxy-phosphoryl]methyl]-3-phenyl-propionic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens angiotensin I converting enzyme 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii thioredoxin reductase 0.0048 0.0126 0.1201
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0075 0.0827
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0397 0.3861
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0065 0.0712
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0084 0.0289 0.0283
Loa Loa (eye worm) hypothetical protein 0.0042 0.0103 0.0261
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0075 0.0069
Entamoeba histolytica hypothetical protein 0.0042 0.0103 0.118
Brugia malayi Protein kinase domain containing protein 0.0023 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0217
Echinococcus granulosus cpg binding protein 0.0031 0.0055 0.0049
Schistosoma mansoni metabotropic glutamate receptor 0.0086 0.0296 0.0679
Brugia malayi A-kinase anchor protein 10, precursor 0.0039 0.0086 0.0211
Schistosoma mansoni nuclear hormone receptor 0.003 0.0046 0.01
Brugia malayi hypothetical protein 0.0119 0.0443 0.1149
Echinococcus multilocularis Excitatory amino acid transporter 0.0249 0.102 0.1014
Brugia malayi Excitatory amino acid transporter 0.0249 0.102 0.2663
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0046 0.01
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0023 0.0018 0.0035
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0069 0.0171
Entamoeba histolytica hypothetical protein 0.0027 0.0036 0.0416
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.045 0.5108
Loa Loa (eye worm) hypothetical protein 0.0685 0.2952 0.7743
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0075 0.0575
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0046 0.004
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0103 0.2152
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0087 0.0082
Schistosoma mansoni hypothetical protein 0.0026 0.003 0.0061
Brugia malayi Zona pellucida-like domain containing protein 0.0042 0.0103 0.0254
Leishmania major cathepsin L-like protease 0.0064 0.02 0.1812
Trichomonas vaginalis rotamase, putative 0.0035 0.0069 0.0008
Schistosoma mansoni hypothetical protein 0.0039 0.0087 0.0195
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0022 0.0012 0.0015
Trichomonas vaginalis set domain proteins, putative 0.1 0.435 1
Echinococcus granulosus survival motor neuron protein 1 0.023 0.0936 0.0931
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0039 0.0086 0.0217
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0173 0.0252
Schistosoma mansoni laminin gamma-3 chain 0.0023 0.0018 0.0035
Leishmania major trypanothione reductase 0.0048 0.0126 0.1083
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0169 0.0667 0.1538
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0126 0.1419
Loa Loa (eye worm) RGC/RGC protein kinase 0.0027 0.0036 0.0086
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0006
Brugia malayi Pre-SET motif family protein 0.0127 0.0477 0.1237
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0046 0.0106
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0173 0.3632
Brugia malayi hypothetical protein 0.0027 0.0036 0.008
Loa Loa (eye worm) hypothetical protein 0.0197 0.0787 0.2059
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0046 0.004
Schistosoma mansoni glutamate receptor NMDA 0.0084 0.0289 0.0663
Trichomonas vaginalis phosphofructokinase, putative 0.0215 0.087 0.1878
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0397 0.3861
Echinococcus multilocularis lamin dm0 0.0082 0.028 0.0274
Onchocerca volvulus 0.003 0.0047 0.0095
Echinococcus multilocularis lamin 0.0082 0.028 0.0274
Echinococcus multilocularis Protein lozenge 0.0056 0.0163 0.0158
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0027 0.0036 0.0086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.02 0.1969
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.02 0.1969
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0145 0.056 0.0554
Plasmodium falciparum thioredoxin reductase 0.0048 0.0126 0.4321
Entamoeba histolytica hypothetical protein, conserved 0.0042 0.0103 0.118
Echinococcus multilocularis musashi 0.0082 0.028 0.0274
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.1027 1
Schistosoma mansoni 6-phosphofructokinase 0.0215 0.087 0.2009
Echinococcus multilocularis sodium:dicarboxylate symporter 0.011 0.0405 0.0399
Trichomonas vaginalis phosphofructokinase, putative 0.0215 0.087 0.1878
Toxoplasma gondii kringle domain-containing protein 0.0023 0.0017 0.0133
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0217
Loa Loa (eye worm) hypothetical protein 0.0083 0.0285 0.0739
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0173 0.1696
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0145 0.056 0.0554
Loa Loa (eye worm) hypothetical protein 0.0053 0.0152 0.039
Treponema pallidum 76K protein 0.0042 0.0103 0.0221
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0249 0.102 0.2357
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0173 0.1647
Echinococcus granulosus expressed protein 0.075 0.324 0.3236
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0103 0.0254
Onchocerca volvulus 0.0446 0.1891 0.4341
Leishmania major ATP-dependent phosphofructokinase 0.0215 0.087 0.8445
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0249 0.102 0.2334
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0152 0.0344
Echinococcus granulosus nmda type glutamate receptor 0.0045 0.0115 0.0109
Brugia malayi regulator of G-protein signaling rgs-7 0.0039 0.0086 0.0211
Schistosoma mansoni lamin 0.0082 0.028 0.0642
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0046 0.0113
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.02 0.227
Schistosoma mansoni glutamate receptor kainate 0.0118 0.0439 0.101
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0086 0.0192
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0217
Entamoeba histolytica phosphofructokinase, putative 0.0215 0.087 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0397 0.3861
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0042 0.0103 0.097
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0233 0.237
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0173 0.1696
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0046 0.0106
Echinococcus multilocularis thyroid hormone receptor alpha 0.0296 0.1226 0.1221
Echinococcus granulosus neutral amino acid transporter A 0.0249 0.102 0.1014
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0042 0.0103 0.2152
Loa Loa (eye worm) hypothetical protein 0.0027 0.0036 0.0086
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0086 0.0192
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.0012 0.0119
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0217
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0046 0.0093
Schistosoma mansoni rab6-interacting 0.002 0.0006 0.0006
Echinococcus multilocularis neutral amino acid transporter A 0.0249 0.102 0.1014
Schistosoma mansoni hypothetical protein 0.0423 0.1792 0.415
Schistosoma mansoni ATP-binding cassette transporter 0.0057 0.0168 0.0382
Schistosoma mansoni tyrosine kinase 0.0027 0.0036 0.0076
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0173 0.6
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0065 0.0747
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0027 0.0036 0.007
Loa Loa (eye worm) RGC/RGC protein kinase 0.0027 0.0036 0.0086
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.011 0.0405 0.0931
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0075 0.0069
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0099 0.0094
Onchocerca volvulus Poor gastrulation protein homolog 0.0024 0.0023 0.0039
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0075 0.0827
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0233 0.2684
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0075 0.047
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0046 0.0093
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.05 0.2133 0.494
Schistosoma mansoni slit 0.0023 0.0018 0.0035
Onchocerca volvulus 0.0042 0.0103 0.0223
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0036 0.0375
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.0103 0.0254
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0039 0.0088 0.0082
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0065 0.0602
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0139 0.1566
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0046 0.01
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0042 0.0103 0.0261
Echinococcus multilocularis neutral amino acid transporter A 0.0249 0.102 0.1014
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0042 0.0103 0.0088
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0213
Schistosoma mansoni lipoxygenase 0.0057 0.0169 0.0383
Loa Loa (eye worm) phosphofructokinase 0.0215 0.087 0.2274
Echinococcus granulosus excitatory amino acid transporter 3 0.0249 0.102 0.1014
Brugia malayi hypothetical protein 0.0039 0.0086 0.0211
Loa Loa (eye worm) glutamate receptor 1 0.0057 0.0168 0.0433
Echinococcus multilocularis geminin 0.0175 0.0693 0.0688
Brugia malayi hypothetical protein 0.0446 0.1891 0.4954
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0113
Brugia malayi laminin-like protein K08C7.3 precursor 0.0023 0.0018 0.0033
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.1792 0.1788
Toxoplasma gondii endonuclease IV APN 0.0083 0.0285 0.2749
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0266 0.1095 0.109
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0217
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0024 0.0023 0.0039
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0088 0.0827
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0086 0.008
Brugia malayi Kringle domain containing protein 0.0023 0.0017 0.0029
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0249 0.102 0.1014
Entamoeba histolytica hypothetical protein, conserved 0.0042 0.0103 0.118
Loa Loa (eye worm) glutamate receptor 0.0162 0.0635 0.1658
Loa Loa (eye worm) hypothetical protein 0.0046 0.012 0.0305
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0087 0.0082
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0046 0.004
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0036 0.1076
Schistosoma mansoni hypothetical protein 0.002 0.0006 0.0006
Onchocerca volvulus 0.0127 0.0477 0.1084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0046 0.0113
Onchocerca volvulus 0.1 0.435 1
Echinococcus granulosus beta-adrenergic receptor kinase 0.0039 0.0086 0.008
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.02 0.227
Echinococcus granulosus voltage dependent calcium channel subunit 0.1035 0.4502 0.4499
Schistosoma mansoni DNA helicase recq1 0.0039 0.0088 0.0196
Plasmodium vivax thrombospondin-related anonymous protein 0.0042 0.0103 0.2152
Mycobacterium ulcerans hypothetical protein 0.0022 0.0012 0.0119
Loa Loa (eye worm) hypothetical protein 0.0042 0.0103 0.0261
Echinococcus granulosus nmda type glutamate receptor 0.0027 0.0036 0.003
Echinococcus multilocularis Excitatory amino acid transporter 0.0249 0.102 0.1014
Loa Loa (eye worm) hypothetical protein 0.0042 0.0103 0.0261
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0046 0.004
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0069 0.0165
Onchocerca volvulus 0.003 0.0046 0.0093
Schistosoma mansoni metabotropic glutamate receptor 0.0138 0.0527 0.1216
Echinococcus granulosus 6 phosphofructokinase 0.0215 0.087 0.0864
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0215 0.087 1
Echinococcus granulosus geminin 0.0175 0.0693 0.0688
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0039 0.0088 0.0222
Schistosoma mansoni thyroid hormone receptor 0.0296 0.1226 0.2835
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0046 0.0106
Toxoplasma gondii aldehyde dehydrogenase 0.0251 0.1027 1
Onchocerca volvulus 0.0047 0.0124 0.0271
Entamoeba histolytica hypothetical protein 0.0039 0.0086 0.099
Echinococcus granulosus bloom syndrome protein 0.0065 0.0204 0.0199
Echinococcus multilocularis tyrosine kinase 0.0027 0.0036 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0086 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0046 0.0106
Loa Loa (eye worm) hypothetical protein 0.0042 0.0103 0.0261
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0042 0.0103 0.0254
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0058 0.0173 0.1659
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0173 0.0167
Loa Loa (eye worm) hypothetical protein 0.0042 0.0103 0.0261
Loa Loa (eye worm) hypothetical protein 0.0023 0.0017 0.0036
Onchocerca volvulus 0.0042 0.0103 0.0223
Echinococcus granulosus collagen alpha 1VII chain 0.0042 0.0103 0.0097
Echinococcus granulosus pikachurin 0.0023 0.0018 0.0013
Schistosoma mansoni cpg binding protein 0.0031 0.0055 0.0119
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0046 0.004
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0046 0.01
Echinococcus granulosus expressed protein 0.0035 0.0069 0.0063
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0046 0.004
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.02 0.227
Schistosoma mansoni cpg binding protein 0.0031 0.0055 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0069 0.0008
Brugia malayi Glutamate receptor 1 precursor 0.0057 0.0168 0.0427
Brugia malayi ecdysteroid receptor 0.003 0.0046 0.0106
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0233 0.0534
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0046 0.004
Loa Loa (eye worm) 6-phosphofructokinase 0.0215 0.087 0.2274
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0145 0.056 0.0554
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0103 0.0254
Plasmodium falciparum thrombospondin-related anonymous protein 0.0042 0.0103 0.3472
Brugia malayi Receptor family ligand binding region containing protein 0.0027 0.0036 0.008
Schistosoma mansoni glutamate receptor AMPA 0.0057 0.0168 0.0382
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0126 0.0121
Toxoplasma gondii 6-phosphofructokinase 0.0058 0.0173 0.1659
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0039 0.0088 0.2948
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0466 0.1982 0.5195
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0196 0.0785 0.2051
Schistosoma mansoni aldehyde dehydrogenase 0.0251 0.1027 0.2374
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0058 0.0173 0.0374
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0075 0.0862
Schistosoma mansoni hypothetical protein 0.0534 0.2284 0.529
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0086 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0086 0.0049
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0024 0.0023 0.0044
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.02 0.1969
Loa Loa (eye worm) hypothetical protein 0.0042 0.0103 0.0261
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0083 0.0285 0.2771
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.02 0.1969
Schistosoma mansoni serine-rich repeat protein 0.0534 0.2284 0.529
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0039 0.0086 0.0217
Onchocerca volvulus 0.0023 0.0017 0.0026
Echinococcus granulosus glutamate NMDA receptor subunit 0.0057 0.0168 0.0163
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0065 0.0476
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0173 0.1684
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0173 0.0167
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.1027 1
Entamoeba histolytica elongation factor-2 kinase, putative 0.0042 0.0103 0.118
Schistosoma mansoni tyrosine kinase 0.0027 0.0036 0.0076
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.1062 0.4623 1
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0249 0.102 0.9931
Brugia malayi Guanylyl cyclase protein 23 0.0027 0.0036 0.008
Entamoeba histolytica hypothetical protein 0.0039 0.0087 0.1004
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0086 0.0049
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0145 0.056 0.0554
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0046 0.004
Echinococcus multilocularis neurogenic locus notch protein 0.0023 0.0018 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.02 0.1969
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0169 0.0163
Trichomonas vaginalis DNA helicase recq1, putative 0.0065 0.0204 0.0325
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0259 0.1063 0.1058
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0057 0.0168 0.0163
Brugia malayi intermediate filament protein 0.0082 0.028 0.072
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0086 0.0192
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0259 0.1063 0.2459
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0197 0.0787 0.0782
Loa Loa (eye worm) CUTiclin family member 0.0042 0.0103 0.0261
Plasmodium vivax SET domain protein, putative 0.0127 0.0477 1
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0111 0.0276
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0086 0.008
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0027 0.0036 0.008
Brugia malayi 6-phosphofructokinase 0.0215 0.087 0.2269
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0215 0.087 1
Brugia malayi Pre-SET motif family protein 0.0879 0.3812 1
Brugia malayi follicle stimulating hormone receptor 0.0466 0.1982 0.5192
Loa Loa (eye worm) hypothetical protein 0.023 0.0936 0.245
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0046 0.004
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0084 0.0289 0.0283
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0251 0.1027 1
Echinococcus granulosus excitatory amino acid transporter 2 0.0249 0.102 0.1014
Treponema pallidum glutamate transporter 0.011 0.0405 0.0875
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0051 0.0143 0.0368
Echinococcus multilocularis neutral amino acid transporter A 0.0249 0.102 0.1014
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0233 0.0604
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0039
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0173 0.0252
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0087 0.03 0.0295
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0175 0.1984
Onchocerca volvulus 0.0042 0.0103 0.0223
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0086 0.0192
Schistosoma mansoni hypothetical protein 0.0175 0.0693 0.1599
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0083 0.0285 0.3176
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0065 0.0712
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0879 0.3812 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.02 0.1969
Toxoplasma gondii exonuclease III APE 0.0058 0.0173 0.1659
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0046 0.01
Echinococcus multilocularis tumor protein p63 0.0364 0.1531 0.1526
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0036 0.0751
Loa Loa (eye worm) hypothetical protein 0.0027 0.0036 0.0086
Loa Loa (eye worm) glutathione reductase 0.0048 0.0126 0.0323
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0075 0.0023
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0039 0.0086 0.0211
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0127 0.0477 0.1098
Echinococcus multilocularis pikachurin 0.0023 0.0018 0.0013
Brugia malayi Bloom's syndrome protein homolog 0.0065 0.0204 0.0521
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0046 0.004
Toxoplasma gondii phosphofructokinase PFKII 0.0058 0.0173 0.1659
Loa Loa (eye worm) glutamate receptor 0.0059 0.0175 0.0451
Brugia malayi regulator of G-protein signaling egl-10 0.0039 0.0086 0.0211
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.028 0.0726
Schistosoma mansoni ap endonuclease 0.0058 0.0173 0.0394
Schistosoma mansoni hypothetical protein 0.0175 0.0693 0.1599
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0173 0.196
Echinococcus granulosus FTZ F1 alpha 0.003 0.0046 0.004
Loa Loa (eye worm) hypothetical protein 0.0446 0.1891 0.4957
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0088 0.0827
Schistosoma mansoni glutamate receptor kainate 0.0118 0.0439 0.101
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0103 0.0254
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.02 0.1969
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0099 0.0094
Plasmodium falciparum glutathione reductase 0.0048 0.0126 0.4321
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0103 0.0254
Echinococcus multilocularis voltage dependent calcium channel subunit 0.2275 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0046 0.004
Echinococcus multilocularis excitatory amino acid transporter 2 0.0249 0.102 0.1014
Entamoeba histolytica hypothetical protein 0.0039 0.0086 0.099
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0086 0.0049
Schistosoma mansoni hypothetical protein 0.0024 0.0023 0.0045
Echinococcus granulosus lamin 0.0082 0.028 0.0274
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0251 0.1027 0.1021
Onchocerca volvulus 0.0042 0.0103 0.0223
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0046 0.0093
Onchocerca volvulus 0.0027 0.0036 0.007
Loa Loa (eye worm) 6-phosphofructokinase 0.0215 0.087 0.2274
Loa Loa (eye worm) intermediate filament protein 0.0082 0.028 0.0726
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0086 0.0049
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0135 0.0514 0.1335
Echinococcus granulosus GPCR family 3 C terminal 0.0024 0.0023 0.0017
Loa Loa (eye worm) TK/ROR protein kinase 0.0023 0.0017 0.0036
Loa Loa (eye worm) RGS-3 protein 0.0039 0.0086 0.0217
Entamoeba histolytica recQ family helicase, putative 0.0044 0.0112 0.1289
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0036 0.1076
Brugia malayi nuclear hormone receptor 0.003 0.0046 0.0106
Brugia malayi metabotropic glutamate receptor type 2 0.0086 0.0296 0.0763
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0169 0.0163
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0397 0.4481
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0086 0.0192
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0046 0.0113
Echinococcus granulosus tumor protein p63 0.0364 0.1531 0.1526
Loa Loa (eye worm) abnormal epIthelia family member 0.0023 0.0018 0.0039
Loa Loa (eye worm) hypothetical protein 0.0042 0.0103 0.0261
Loa Loa (eye worm) hypothetical protein 0.0027 0.0036 0.0086
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0042 0.0103 0.0261
Loa Loa (eye worm) hypothetical protein 0.0042 0.0103 0.0261
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0126 0.1228
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0027 0.0036 0.003
Onchocerca volvulus 0.0042 0.0103 0.0223
Brugia malayi laminin alpha chain 0.0023 0.0018 0.0033
Loa Loa (eye worm) doublecortin family protein 0.002 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0027 0.0036 0.0085
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0039 0.0086 0.0217
Entamoeba histolytica phosphofructokinase, putative 0.0215 0.087 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0124 0.0309
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0233 0.0228
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0086 0.008
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0173 0.9997
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0113
Loa Loa (eye worm) hypothetical protein 0.0051 0.0143 0.0368
Loa Loa (eye worm) hypothetical protein 0.0027 0.0036 0.0086
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0039 0.0086 0.0049
Schistosoma mansoni thyroid hormone receptor 0.0296 0.1226 0.2835
Entamoeba histolytica recQ family DNA helicase 0.002 0.0003 0.0039
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0088 0.0216
Echinococcus multilocularis NMDA receptor 0.0087 0.03 0.0295
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0087 0.03 0.0295
Echinococcus granulosus lamin dm0 0.0082 0.028 0.0274
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0046 0.01
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0112 0.1255
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0046 0.0106
Chlamydia trachomatis endonuclease IV 0.0083 0.0285 0.279
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0112 0.0942
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0046 0.0106
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0145 0.056 0.0554
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.004 0.0092 0.0869
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0173 0.6001
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0173 0.0374
Echinococcus multilocularis Regulator of G protein signaling 20 0.0039 0.0086 0.008
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0106 0.0385 0.038
Schistosoma mansoni hypothetical protein 0.0047 0.0124 0.0279
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0173 0.0252
Loa Loa (eye worm) hypothetical protein 0.0081 0.0273 0.0709
Loa Loa (eye worm) hypothetical protein 0.0039 0.0088 0.0222
Echinococcus granulosus Regulator of G protein signaling 20 0.0039 0.0086 0.008
Onchocerca volvulus 0.0082 0.028 0.0631
Schistosoma mansoni coup transcription factor 0.003 0.0046 0.01
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0086 0.008
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0042 0.0103 0.0097
Brugia malayi hypothetical protein 0.0039 0.0086 0.0211
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0173 0.0446
Entamoeba histolytica hypothetical protein 0.0039 0.0087 0.1004
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0103 0.0254
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0075 0.0023
Loa Loa (eye worm) hypothetical protein 0.0042 0.0103 0.0261
Schistosoma mansoni hypothetical protein 0.0023 0.0017 0.0032
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0046 0.0106
Schistosoma mansoni glutamate receptor AMPA 0.0057 0.0168 0.0382
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0042 0.0103 0.0261
Loa Loa (eye worm) hypothetical protein 0.0042 0.0103 0.0261
Schistosoma mansoni 6-phosphofructokinase 0.0215 0.087 0.2009
Onchocerca volvulus 0.0053 0.0152 0.0336
Entamoeba histolytica hypothetical protein 0.0039 0.0086 0.099
Schistosoma mansoni glutamate receptor kainate 0.0057 0.0168 0.0382
Schistosoma mansoni glutamate receptor NMDA 0.0057 0.0168 0.0382
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.02 0.1969
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0173 0.1991
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0046 0.0113
Trypanosoma brucei trypanothione reductase 0.0048 0.0126 0.1085
Brugia malayi PXA domain containing protein 0.0039 0.0086 0.0211
Echinococcus granulosus neutral amino acid transporter A 0.0249 0.102 0.1014
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0039
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.0936 0.0931
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0039
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0086 0.0211
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0173 0.1684
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0036 0.0317
Echinococcus granulosus metabotropic glutamate receptor 2 0.0138 0.0527 0.0522
Brugia malayi Zona pellucida-like domain containing protein 0.0042 0.0103 0.0254
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0249 0.102 1
Schistosoma mansoni hypothetical protein 0.0266 0.1095 0.2532
Echinococcus granulosus histone lysine methyltransferase setb 0.0127 0.0477 0.0471
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0215 0.087 0.1881
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0046 0.0106
Echinococcus granulosus leukotriene A 4 hydrolase 0.0259 0.1063 0.1058
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.02 0.227
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0145 0.056 0.0554
Echinococcus granulosus sodium:dicarboxylate symporter 0.0249 0.102 0.1014
Onchocerca volvulus 0.0042 0.0103 0.0223
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0026 0.003 0.0024
Trichomonas vaginalis DNA helicase recq, putative 0.0065 0.0204 0.0325
Echinococcus multilocularis glutamate receptor 2 0.0058 0.0175 0.0169
Loa Loa (eye worm) hypothetical protein 0.0027 0.0036 0.0086
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0173 0.0252
Schistosoma mansoni polycystin 1-related 0.002 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0113
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.011 0.0405 0.0399
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0087 0.0195
Brugia malayi glutathione reductase 0.0048 0.0126 0.0317
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0086 0.0192
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.1027 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.045 0.4384
Echinococcus multilocularis cpg binding protein 0.0031 0.0055 0.0049
Chlamydia trachomatis neutral amino acid transporter 0.011 0.0405 0.3968
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0173 0.3632
Echinococcus granulosus neutral amino acid transporter 0.0249 0.102 0.1014
Echinococcus multilocularis GPCR, family 3, C terminal 0.0024 0.0023 0.0017
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0039 0.0086 0.008
Brugia malayi hypothetical protein 0.0042 0.0103 0.0254
Schistosoma mansoni lipoxygenase 0.002 0.0006 0.0006
Schistosoma mansoni ap endonuclease 0.0058 0.0173 0.0394
Echinococcus granulosus glutamate receptor 2 0.0058 0.0175 0.0169
Echinococcus granulosus dnaJ subfamily B 0.0423 0.1792 0.1788
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0249 0.102 0.1014
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0086 0.008
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0121 0.0453 0.0448
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0113
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0039 0.0088 0.0082
Loa Loa (eye worm) RGC/RGC protein kinase 0.0027 0.0036 0.0086
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0006 0.0122
Brugia malayi hypothetical protein 0.023 0.0936 0.2445
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0173 0.0252
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0213
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0397 0.3861
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0083 0.0285 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0397 0.3861
Loa Loa (eye worm) hypothetical protein 0.0042 0.0103 0.0261
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0173 0.0252
Echinococcus granulosus tyrosine kinase 0.0027 0.0036 0.003
Loa Loa (eye worm) hypothetical protein 0.0042 0.0103 0.0261
Brugia malayi Thioredoxin reductase 0.0048 0.0126 0.0317
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0259 0.1063 0.2783
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0103 0.0254
Brugia malayi Receptor family ligand binding region containing protein 0.0051 0.0143 0.0361
Schistosoma mansoni cpg binding protein 0.003 0.0047 0.0102
Schistosoma mansoni loxhd1 0.002 0.0006 0.0006
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0046 0.004
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0173 0.0252
Echinococcus multilocularis tissue type plasminogen activator 0.0023 0.0017 0.0011
Brugia malayi Cache domain containing protein 0.0458 0.1946 0.5097
Brugia malayi CXXC zinc finger family protein 0.003 0.0047 0.0109
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0113
Schistosoma mansoni rotamase 0.0035 0.0069 0.0151
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0233 0.2656
Leishmania major extracellular receptor, putative 0.0027 0.0036 0.019
Brugia malayi Angiotensin-converting enzyme family protein 0.0196 0.0785 0.2046
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0233 0.2144
Schistosoma mansoni DNA helicase recq5 0.0039 0.0088 0.0196
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0047 0.0115
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.045 0.4384
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0046 0.0106
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0039 0.0088 0.0082
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0173 0.196
Treponema pallidum glutamate/aspartate transporter 0.011 0.0405 0.0875
Loa Loa (eye worm) hypothetical protein 0.0027 0.0036 0.0086
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0113
Loa Loa (eye worm) hypothetical protein 0.004 0.0091 0.0231
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0086 0.008
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0042 0.0103 0.3472
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0111 0.0282
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0477 0.1098
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0046 0.004
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.3637 0.3633
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0046 0.004
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0042 0.0103 0.2152
Treponema pallidum hypothetical protein 0.0042 0.0103 0.0221
Schistosoma mansoni lozenge 0.0056 0.0163 0.0371
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.02 0.1969
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0024
Loa Loa (eye worm) PXA domain-containing protein 0.0039 0.0086 0.0217
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0075 0.0166
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0215 0.087 0.847
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0233 0.0228
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.0012 0.0017
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0086 0.008
Schistosoma mansoni hypothetical protein 0.0042 0.0103 0.023
Schistosoma mansoni z-protein (S1r protein) 0.0039 0.0086 0.0192
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0086 0.0192
Brugia malayi hypothetical protein 0.0039 0.0087 0.0214
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0091 0.0086
Schistosoma mansoni blooms syndrome DNA helicase 0.0045 0.0116 0.0262
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0075 0.0166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0046 0.0113
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.011 0.0405 0.0931
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0088 0.0216
Echinococcus multilocularis expressed protein 0.075 0.324 0.3236
Echinococcus multilocularis nmda type glutamate receptor 0.0045 0.0115 0.0109
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0039 0.0086 0.008
Echinococcus granulosus Excitatory amino acid transporter 0.0249 0.102 0.1014
Leishmania major cathepsin L-like protease 0.0064 0.02 0.1812
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0051 0.0143 0.0368
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0173 0.3631
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0173 0.044
Brugia malayi hypothetical protein 0.0263 0.1081 0.2824
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0251 0.1027 1
Echinococcus multilocularis excitatory amino acid transporter 3 0.0249 0.102 0.1014
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0036 0.0375
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0173 0.6001
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0233 0.0598
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1035 0.4502 0.4499
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0266 0.1095 0.109
Entamoeba histolytica hypothetical protein 0.0039 0.0087 0.1004
Brugia malayi steroid hormone receptor 0.003 0.0046 0.0106
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0075 0.0069
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0039 0.0086 0.0192
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0046 0.0106
Echinococcus multilocularis beta adrenergic receptor kinase 0.0039 0.0086 0.008
Mycobacterium ulcerans 6-phosphofructokinase 0.0215 0.087 0.847
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0046 0.01
Brugia malayi nuclear receptor NHR-88 0.003 0.0046 0.0106
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0091 0.0086
Trichomonas vaginalis phosphofructokinase, putative 0.0215 0.087 0.1878
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.02 0.1969
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0042 0.0103 0.3472
Plasmodium vivax glutathione reductase, putative 0.0048 0.0126 0.2649
Echinococcus multilocularis regulator of G protein signaling 0.0039 0.0086 0.008
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0065 0.035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0477 0.1098
Mycobacterium ulcerans epimerase 0.0022 0.0012 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0046 0.0106
Echinococcus granulosus neurogenic locus notch protein 0.0023 0.0018 0.0013
Echinococcus multilocularis slit 2 protein 0.0023 0.0018 0.0013
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0086 0.0192
Schistosoma mansoni rab6-interacting 0.002 0.0006 0.0006
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0087 0.03 0.0295
Echinococcus granulosus Excitatory amino acid transporter 0.0249 0.102 0.1014
Loa Loa (eye worm) hypothetical protein 0.0042 0.0103 0.0261
Echinococcus granulosus excitatory amino acid transporter 2 0.0249 0.102 0.1014
Echinococcus multilocularis excitatory amino acid transporter 2 0.0249 0.102 0.1014
Echinococcus granulosus slit 2 protein 0.0023 0.0018 0.0013
Echinococcus granulosus intermediate filament protein 0.0082 0.028 0.0274
Brugia malayi Metabotropic glutamate receptor precursor. 0.0162 0.0635 0.1652
Trypanosoma cruzi extracellular receptor, putative 0.0027 0.0036 0.0378
Treponema pallidum ATP-dependent DNA helicase 0.002 0.0003 0.0007
Trichomonas vaginalis phosphofructokinase, putative 0.0215 0.087 0.1878
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0126 0.0121
Brugia malayi PXA domain containing protein 0.0039 0.0086 0.0211
Leishmania major hypothetical protein, conserved 0.0027 0.0036 0.0187
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0477 0.1098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.02 0.1969
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0046 0.0113
Brugia malayi 6-phosphofructokinase 0.0215 0.087 0.2269
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0046 0.01
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0039 0.0088 0.0082
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0992 0.4315 1
Plasmodium falciparum cysteine repeat modular protein 1 0.0023 0.0017 0.0401
Brugia malayi von Willebrand Factor 0.0042 0.0103 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0046 0.0106
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0126 0.0323
Echinococcus multilocularis glutamate receptor 2 0.0057 0.0168 0.0163
Echinococcus granulosus glutamate receptor 2 0.0084 0.0289 0.0283
Echinococcus multilocularis receptor type guanylyl cyclase 0.0027 0.0036 0.003
Echinococcus multilocularis nmda type glutamate receptor 0.0027 0.0036 0.003
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0012 0.0119
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0046 0.004
Loa Loa (eye worm) excitatory amino acid transporter 0.0249 0.102 0.2668
Loa Loa (eye worm) glutamate receptor 2 0.0057 0.0168 0.0433
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0075 0.0069
Brugia malayi hypothetical protein 0.0027 0.0036 0.0079
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0023 0.0018 0.0033
Schistosoma mansoni cell polarity protein 0.0023 0.0018 0.0035
Schistosoma mansoni lamin 0.0082 0.028 0.0642
Brugia malayi Cytochrome P450 family protein 0.0074 0.0245 0.0629
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0083 0.0285 0.0733
Loa Loa (eye worm) hypothetical protein 0.0082 0.028 0.0726
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0046 0.004
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0017 0.0157
Schistosoma mansoni survival motor neuron protein 0.0047 0.0124 0.0279
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0086 0.0192
Loa Loa (eye worm) hypothetical protein 0.0458 0.1946 0.51
Loa Loa (eye worm) hypothetical protein 0.0036 0.0075 0.0188
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0042 0.0103 0.2152
Toxoplasma gondii microneme protein MIC2 0.0042 0.0103 0.097
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0217
Mycobacterium ulcerans endonuclease IV 0.0083 0.0285 0.2771
Entamoeba histolytica phosphofructokinase, putative 0.0215 0.087 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0074 0.0245 0.0635
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0086 0.0192
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0075 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0046 0.0106
Echinococcus granulosus glutamate receptor subunit protein glur 0.0026 0.003 0.0024
Schistosoma mansoni hypothetical protein 0.0042 0.0103 0.023
Brugia malayi EGF-like domain containing protein 0.0023 0.0018 0.0033
Loa Loa (eye worm) CUTiclin-Like family member 0.0042 0.0103 0.0261
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0026 0.003 0.0024
Chlamydia trachomatis glutamate symporter 0.0249 0.102 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.045 0.4384
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0086 0.008
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0058 0.0173 0.0252
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0215 0.0492
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0023 0.0017 0.0356
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0112 0.0914
Onchocerca volvulus 0.0027 0.0036 0.007
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0186 0.1781
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0173 0.0252
Echinococcus multilocularis 6 phosphofructokinase 0.0215 0.087 0.0864
Loa Loa (eye worm) hypothetical protein 0.0446 0.1891 0.4957
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0086 0.0192
Onchocerca volvulus 0.0042 0.0103 0.0223
Echinococcus multilocularis glutamate receptor 2 0.0084 0.0289 0.0283
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0086 0.008
Onchocerca volvulus 0.0082 0.028 0.0631
Echinococcus multilocularis expressed protein 0.0035 0.0069 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0046 0.0113
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0083 0.0285 0.5971
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0086 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0046 0.0113
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0086 0.008
Entamoeba histolytica hypothetical protein 0.0039 0.0087 0.1004
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0086 0.0049
Leishmania major cathepsin L-like protease 0.0064 0.02 0.1812
Schistosoma mansoni aldehyde dehydrogenase 0.0251 0.1027 0.2374
Brugia malayi phosphofructokinase 0.0215 0.087 0.2269
Loa Loa (eye worm) hypothetical protein 0.0027 0.0036 0.0086
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0046 0.01
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0112 0.011
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0086 0.008
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0173 0.1546
Echinococcus granulosus tissue type plasminogen activator 0.0023 0.0017 0.0011
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0127 0.0477 0.0471
Loa Loa (eye worm) runx1 0.0056 0.0163 0.042
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0075 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0046 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0075 0.0023
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0103 0.0254
Giardia lamblia Sgs1 DNA helicase, putative 0.0039 0.0088 0.1327
Echinococcus granulosus receptor type guanylyl cyclase 0.0027 0.0036 0.003
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0126 0.2649
Schistosoma mansoni protein kinase 0.0027 0.0036 0.0076
Schistosoma mansoni intermediate filament proteins 0.0082 0.028 0.0642
Brugia malayi Glutamate receptor 2 precursor 0.0057 0.0168 0.0427
Echinococcus granulosus metabotropic glutamate receptor 5 0.0197 0.0787 0.0782
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0215 0.087 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0058 0.0173 0.1991
Loa Loa (eye worm) hypothetical protein 0.0127 0.0477 0.1243
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0075 0.0069
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.006 0.018 0.6256
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0058 0.0173 1
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0026 0.003 0.0024
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0127 0.0477 0.4626
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0086 0.0192
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0113
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0233 0.2656
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0251 0.1027 0.1021
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0046 0.0106
Mycobacterium tuberculosis Probable reductase 0.0109 0.0397 0.3861
Loa Loa (eye worm) RecQ helicase 0.0065 0.0204 0.0528
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0113
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0127 0.0477 0.0471
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0138 0.0527 0.0522
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.028 0.072
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0103 0.0254
Echinococcus granulosus atrial natriuretic peptide receptor 0.0027 0.0036 0.003
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0041 0.0096 0.2005
Echinococcus multilocularis bloom syndrome protein 0.0065 0.0204 0.0199
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0046 0.0106
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0046 0.01

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 5.2 nM Inhibition of ACE2 (unknown origin) ChEMBL. 18324760
Ki (binding) = 5.2 nM Inhibition of ACE2 (unknown origin) ChEMBL. 18324760

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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