TDR Targets

Basic information

Technical information

TDR Targets ID: 512157
Name: N-[6-(3-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyri din-3-yl]cyclopropanecarboxamide
MW: 294.308 | Formula: C16H14N4O2
H donors: 3 H acceptors: 4 LogP: 2.09 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C1CC1)Nc1n[nH]c2c1ccc(n2)c1cccc(c1)O
InChi: 1S/C16H14N4O2/c21-11-3-1-2-10(8-11)13-7-6-12-14(17-13)19-20-15(12)18-16(22)9-4-5-9/h1-3,6-9,21H,4-5H2,(H2,17,18,19,20,22)
InChiKey: AXWDQRXGOKDXJT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[6-(3-hydroxyphenyl)-1H-pyrazolo[5,4-b]pyridin-3-yl]cyclopropanecarboxamide
6-aryl-pyrazolo[3,4-b]pyridine analogue 8

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glycogen synthase kinase 3 beta	Starlite/ChEMBL	References
Homo sapiens	glycogen synthase kinase 3 alpha	Starlite/ChEMBL	References
Homo sapiens	myosin light chain kinase	Starlite/ChEMBL	References
Homo sapiens	cyclin-dependent kinase 3	Starlite/ChEMBL	References
Homo sapiens	Pim-2 proto-oncogene, serine/threonine kinase	Starlite/ChEMBL	References
Homo sapiens	MAP/microtubule affinity-regulating kinase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	likely protein kinase similar to S. cerevisiae KIN1 (YDR122W) and KIN2 (YLR096W)	Get druggable targets OG5_128024	All targets in OG5_128024
Schistosoma japonicum	ko:K08798 MAP/microtubule affinity-regulating kinase, putative	Get druggable targets OG5_128024	All targets in OG5_128024
Trypanosoma congolense	cdc2-related kinase 3, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma cruzi	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	cyclin dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania braziliensis	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania braziliensis	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Cryptosporidium parvum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	serine:threonine protein kinase	Get druggable targets OG5_128024	All targets in OG5_128024
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_128024	All targets in OG5_128024
Echinococcus multilocularis	serine:threonine protein kinase MARK2	Get druggable targets OG5_128024	All targets in OG5_128024
Leishmania donovani	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium hominis	cdc2-like protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma japonicum	ko:K08822 glycogen synthase kinase 3 alpha, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	serine:threonine protein kinase	Get druggable targets OG5_133428	All targets in OG5_133428
Echinococcus multilocularis	cyclin dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium yoelii	cdc2-related kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium vivax	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	myosin light chain kinase, smooth muscle	Get druggable targets OG5_133428	All targets in OG5_133428
Leishmania major	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma congolense	cdc2-related kinase 1, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania infantum	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Giardia lamblia	Kinase, CMGC CDK	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma cruzi	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	serine:threonine protein kinase	Get druggable targets OG5_133428	All targets in OG5_133428
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_128024	All targets in OG5_128024
Echinococcus multilocularis	serine:threonine protein kinase	Get druggable targets OG5_128024	All targets in OG5_128024
Candida albicans	Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma japonicum	ko:K02087 cyclin-dependent kinase 1, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium berghei	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	myosin light chain kinase smooth muscle	Get druggable targets OG5_133428	All targets in OG5_133428
Plasmodium knowlesi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128024	All targets in OG5_128024
Leishmania mexicana	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Neospora caninum	CMGC kinase, CDK family TgPK2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei gambiense	cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Theileria parva	cell division control protein 2 related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	cell division protein kinase 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	CAMK/CAMKL/MARK protein kinase	Get druggable targets OG5_128024	All targets in OG5_128024
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	serine:threonine protein kinase MARK2	Get druggable targets OG5_128024	All targets in OG5_128024
Echinococcus multilocularis	cyclin dependent kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Candida albicans	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania braziliensis	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_128024	All targets in OG5_128024
Plasmodium falciparum	protein kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Neospora caninum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei gambiense	cell division related protein kinase 2, putative,CDC2-related protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania mexicana	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	cell division protein kinase 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Cryptosporidium parvum	Cdc2-like CDK2/CDC28 like protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	ko:K02090 cyclin-dependent kinase 5, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium falciparum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	serine:threonine protein kinase	Get druggable targets OG5_128024	All targets in OG5_128024
Giardia lamblia	Kinase, CMGC CDK	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium knowlesi	Cell division control protein 2 homolog	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	serine:threonine protein kinase MARK2	Get druggable targets OG5_128024	All targets in OG5_128024
Trypanosoma brucei gambiense	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania donovani	cell division protein kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Theileria parva	glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania donovani	cdc2-related kinase 3, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_128024	All targets in OG5_128024
Echinococcus multilocularis	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium berghei	cdc2-related kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma cruzi	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania mexicana	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania infantum	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Babesia bovis	cell division control protein 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium vivax	protein kinase Crk2	Get druggable targets OG5_126712	All targets in OG5_126712
Onchocerca volvulus		Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Candida albicans	Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Babesia bovis	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Brugia malayi	cell division control protein 2 homolog	Get druggable targets OG5_126712	All targets in OG5_126712
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Brugia malayi	intracellular kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	serine:threonine protein kinase	Get druggable targets OG5_128024	All targets in OG5_128024
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	serine:threonine protein kinase MARK2	Get druggable targets OG5_128024	All targets in OG5_128024
Leishmania infantum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma cruzi	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Candida albicans	Serine/threonine protein kinase required for induction of IME2 by Ime1p	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	cyclin dependent kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	protein lipid droplet kinase (LDK)	Pim-2 proto-oncogene, serine/threonine kinase	311 aa	278 aa	28.8 %
Trypanosoma brucei	mitogen-activated protein kinase 5	cyclin-dependent kinase 3	305 aa	303 aa	32.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	nuclear receptor RXR	0.0009	0.004	0.0025
Brugia malayi	nuclear hormone receptor	0.0009	0.004	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0164	0.0244
Schistosoma mansoni	hypothetical protein	0.0059	0.0894	0.158
Echinococcus granulosus	titin	0.0009	0.0034	0.0086
Echinococcus granulosus	serine:threonine protein kinase MARK2	0.0088	0.1406	0.3516
Onchocerca volvulus		0.0019	0.0204	0.0942
Brugia malayi	hypothetical protein	0.0011	0.006	0.006
Trichomonas vaginalis	glutaminase, putative	0.0333	0.5658	1
Giardia lamblia	Kinase, CMGC GSK	0.0118	0.1917	1
Schistosoma mansoni	netrin receptor unc5	0.0017	0.0164	0.0289
Brugia malayi	Flap endonuclease-1	0.0013	0.0105	0.0141
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0009	0.004	0.004
Echinococcus granulosus	death domain containing protein	0.0017	0.0164	0.041
Schistosoma mansoni	patched 1	0.0061	0.0932	0.1647
Loa Loa (eye worm)	hypothetical protein	0.0021	0.024	0.0379
Plasmodium vivax	patched family protein, putative	0.0009	0.0026	0.0136
Loa Loa (eye worm)	TAR-binding protein	0.0161	0.2663	0.4682
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0769	0.132
Trichomonas vaginalis	CMGC family protein kinase	0.0118	0.1917	0.3389
Schistosoma mansoni	hypothetical protein	0.001	0.0045	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0514	0.0865
Echinococcus multilocularis	titin	0.0009	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0117	0.191	0.3345
Echinococcus multilocularis	FTZ F1 alpha	0.002	0.0223	0.0223
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0085	0.1345	0.1345
Toxoplasma gondii	patched family protein	0.0009	0.0026	0.0136
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0009	0.004	0.0025
Trichomonas vaginalis	esterase, putative	0.0026	0.0323	0.057
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.002	0.0223	0.0349
Mycobacterium leprae	conserved hypothetical protein	0.0026	0.0323	0.5
Schistosoma mansoni	hypothetical protein	0.0195	0.3256	0.5755
Onchocerca volvulus		0.0019	0.0204	0.0942
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0118	0.1917	0.3358
Brugia malayi	photoreceptor-specific nuclear receptor	0.002	0.0223	0.0349
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.001	0.0045	0.0045
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.002	0.0223	0.0223
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0053	0.0793	0.0793
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0017	0.0164	0.041
Plasmodium vivax	hypothetical protein, conserved	0.0026	0.0323	0.1683
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0031	0.0407	0.0677
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.002	0.0223	0.0394
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.001	0.0045	0.0112
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.002	0.0223	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0323	0.0527
Echinococcus granulosus	serine:threonine protein kinase	0.0238	0.3998	1
Schistosoma mansoni	nuclear hormone receptor	0.002	0.0223	0.0394
Plasmodium falciparum	glycogen synthase kinase 3	0.0118	0.1917	1
Trichomonas vaginalis	flap endonuclease-1, putative	0.0013	0.0105	0.0186
Plasmodium vivax	multidomain scavenger receptor, putative	0.0019	0.0204	0.1065
Echinococcus granulosus	Ankyrin	0.0017	0.0166	0.0416
Schistosoma mansoni	serine/threonine kinase	0.0039	0.0561	0.0991
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.002	0.0223	0.0557
Schistosoma mansoni	nuclear hormone receptor	0.0009	0.004	0.0071
Echinococcus granulosus	sterol regulatory element binding protein	0.0061	0.0932	0.2331
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0818	0.1406
Brugia malayi	follicle stimulating hormone receptor	0.0267	0.4514	0.797
Schistosoma mansoni	rab6-interacting	0.0019	0.0204	0.0361
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0267	0.4514	0.797
Leishmania major	hypothetical protein, conserved	0.0026	0.0323	0.1199
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.002	0.0223	0.0349
Loa Loa (eye worm)	CAMK/CAMKL/MARK protein kinase	0.0051	0.0769	0.132
Trypanosoma cruzi	cdc2-related kinase 1	0.0054	0.0818	0.3934
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0.1917	0.821
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0164	0.2724	1
Loa Loa (eye worm)	DR-78	0.0009	0.004	0.0025
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0118	0.1917	1
Schistosoma mansoni	lipoxygenase	0.0053	0.0793	0.1402
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.002	0.0223	0.0394
Brugia malayi	Death domain containing protein	0.0017	0.0164	0.0244
Entamoeba histolytica	cell division protein kinase 2, putative	0.0054	0.0818	0.3503
Brugia malayi	Protein kinase domain containing protein	0.0019	0.0211	0.0328
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0223	0.0349
Schistosoma mansoni	hypothetical protein	0.0059	0.0894	0.158
Onchocerca volvulus		0.0026	0.0323	0.1568
Loa Loa (eye worm)	hypothetical protein	0.0009	0.004	0.0025
Brugia malayi	intracellular kinase	0.0118	0.1917	0.3358
Entamoeba histolytica	hypothetical protein	0.0026	0.0326	0.1397
Echinococcus multilocularis	protein patched	0.0061	0.0932	0.0932
Echinococcus multilocularis	protein kinase shaggy	0.0118	0.1917	0.1917
Echinococcus granulosus	FTZ F1 alpha	0.002	0.0223	0.0557
Brugia malayi	steroid hormone receptor	0.002	0.0223	0.0349
Loa Loa (eye worm)	flap endonuclease-1	0.0013	0.0105	0.0141
Echinococcus multilocularis	protein dispatched 1	0.0069	0.1081	0.1081
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0223	0.0223
Schistosoma mansoni	nuclear receptor	0.0009	0.004	0.0071
Echinococcus granulosus	myosin light chain kinase smooth muscle	0.0238	0.3998	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.004	0.0025
Schistosoma mansoni	hypothetical protein	0.0145	0.2387	0.4219
Brugia malayi	hypothetical protein	0.0019	0.0204	0.0316
Schistosoma mansoni	tar DNA-binding protein	0.0161	0.2663	0.4707
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0323	0.0527
Brugia malayi	cell division control protein 2 homolog	0.0054	0.0818	0.1406
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0118	0.1917	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0045	0.0033
Schistosoma mansoni	serine/threonine protein kinase	0.0039	0.0561	0.0991
Schistosoma mansoni	hypothetical protein	0.0195	0.3256	0.5755
Schistosoma mansoni	steroid hormone receptor ad4bp	0.002	0.0223	0.0394
Schistosoma mansoni	serine/threonine protein kinase	0.0039	0.0561	0.0991
Onchocerca volvulus	Netrin receptor homolog	0.0019	0.0214	0.0991
Echinococcus multilocularis	cyclin dependent kinase 1	0.0054	0.0818	0.0818
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0204	0.0204
Echinococcus multilocularis	serine:threonine protein kinase MARK2	0.0088	0.1406	0.1406
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0323	0.0527
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0009	0.0034	0.0015
Echinococcus granulosus	GPCR family 2	0.001	0.0045	0.0112
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.002	0.0223	0.0349
Trypanosoma brucei	cdc2-related kinase 1	0.0054	0.0818	0.3934
Echinococcus granulosus	titin	0.0009	0.0034	0.0086
Brugia malayi	ecdysone receptor	0.0009	0.004	0.0025
Echinococcus multilocularis	cyclin dependent kinase 5	0.0054	0.0818	0.0818
Schistosoma mansoni	retinoic acid receptor RXR	0.002	0.0223	0.0394
Schistosoma mansoni	hypothetical protein	0.0019	0.0204	0.0361
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0017	0.0166	0.0294
Schistosoma mansoni	hypothetical protein	0.001	0.0045	0.0079
Echinococcus multilocularis	cyclin dependent kinase 1	0.0054	0.0818	0.0818
Entamoeba histolytica	hypothetical protein	0.0026	0.0326	0.1397
Echinococcus multilocularis	ecdysone induced protein 78C	0.002	0.0223	0.0223
Onchocerca volvulus	Huntingtin homolog	0.0117	0.191	0.996
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0223	0.0349
Brugia malayi	Doublecortin family protein	0.0019	0.0204	0.0316
Schistosoma mansoni	hypothetical protein	0.0021	0.024	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1169	0.203
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0165	0.2733	0.2733
Echinococcus multilocularis	serine:threonine protein kinase	0.0238	0.3998	0.3998
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.1033	0.1331
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0031	0.0407	0.0677
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.002	0.0223	0.104
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0118	0.1917	0.4795
Entamoeba histolytica	hypothetical protein	0.0026	0.0326	0.1397
Giardia lamblia	Flap structure-specific endonuclease	0.0013	0.0105	0.055
Schistosoma mansoni	hypothetical protein	0.0026	0.0326	0.0577
Plasmodium falciparum	ataxin-2 like protein, putative	0.0018	0.0189	0.0986
Brugia malayi	RNA recognition motif domain containing protein	0.0161	0.2663	0.4682
Brugia malayi	ecdysteroid receptor	0.002	0.0223	0.0349
Schistosoma mansoni	nuclear hormone receptor	0.0009	0.004	0.0071
Echinococcus granulosus	protein kinase shaggy	0.0118	0.1917	0.4795
Loa Loa (eye worm)	hypothetical protein	0.0009	0.004	0.0025
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0085	0.1345	0.3365
Schistosoma mansoni	thyroid hormone receptor	0.0165	0.2733	0.4831
Entamoeba histolytica	hypothetical protein	0.0026	0.0326	0.1397
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0769	0.132
Echinococcus multilocularis	serine:threonine protein kinase	0.0051	0.0769	0.0769
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0818	0.1446
Loa Loa (eye worm)	hypothetical protein	0.0009	0.004	0.0025
Brugia malayi	Kinase associated domain 1 family protein	0.0037	0.0514	0.0865
Echinococcus granulosus	serine:threonine protein kinase	0.0051	0.0769	0.1924
Toxoplasma gondii	hypothetical protein	0.0009	0.0026	0.0136
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.002	0.0223	0.0349
Brugia malayi	Steroid receptor seven-up type 2	0.002	0.0223	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0009	0.004	0.0025
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.002	0.0223	0.0557
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0009	0.004	0.0074
Echinococcus multilocularis	serine:threonine protein kinase	0.0051	0.0769	0.0769
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0054	0.0818	0.4267
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.002	0.0223	0.0349
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0009	0.004	0.004
Trypanosoma cruzi	cdc2-related kinase 3	0.0054	0.0818	0.3934
Entamoeba histolytica	Flap nuclease, putative	0.0013	0.0105	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0204	0.0316
Mycobacterium ulcerans	glutaminase	0.0333	0.5658	1
Onchocerca volvulus		0.0009	0.0034	0.0043
Echinococcus multilocularis	Ankyrin	0.0017	0.0166	0.0166
Schistosoma mansoni	serine/threonine protein kinase	0.0088	0.1406	0.2484
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.1033	0.1825
Loa Loa (eye worm)	glutaminase 2	0.0333	0.5658	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.002	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0323	0.0527
Loa Loa (eye worm)	nuclear hormone receptor	0.0009	0.004	0.0025
Brugia malayi	hypothetical protein	0.0026	0.0326	0.0533
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.002	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0204	0.0316
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0054	0.0818	0.3934
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0818	0.1446
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0026	0.0326	0.0816
Loa Loa (eye worm)	hypothetical protein	0.002	0.0223	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0009	0.004	0.0025
Schistosoma mansoni	hypothetical protein	0.001	0.0045	0.0079
Plasmodium falciparum	protein kinase 5	0.0054	0.0818	0.4267
Loa Loa (eye worm)	hypothetical protein	0.0142	0.2335	0.41
Toxoplasma gondii	patched family protein	0.0009	0.0026	0.0136
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0026	0.0323	0.0527
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.002	0.0223	0.0557
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0118	0.1917	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0009	0.004	0.004
Schistosoma mansoni	hypothetical protein	0.0059	0.0894	0.158
Schistosoma mansoni	tar DNA-binding protein	0.0161	0.2663	0.4707
Echinococcus multilocularis	Niemann Pick C1 protein	0.0203	0.339	0.339
Trypanosoma brucei	protein kinase, putative	0.0118	0.1917	1
Echinococcus multilocularis	hypothetical protein	0.0037	0.0514	0.0514
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0407	0.0677
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0067	0.1033	0.2957
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0017	0.0164	0.0164
Brugia malayi	nuclear receptor RXR	0.0011	0.006	0.006
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.002	0.0223	0.0349
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.002	0.0223	0.0394
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0223	0.0349
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0067	0.1033	0.1033
Trypanosoma cruzi	hypothetical protein, conserved	0.0026	0.0323	0.1199
Onchocerca volvulus		0.0118	0.1917	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.002	0.0223	0.0223
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0026	0.0323	0.057
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0144	0.2373	0.4195
Echinococcus multilocularis	Niemann Pick C1 protein	0.0142	0.2335	0.2335
Loa Loa (eye worm)	hypothetical protein	0.0117	0.191	0.3345
Brugia malayi	Niemann-Pick C1 protein precursor	0.0142	0.2335	0.41
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0061	0.0932	0.1608
Schistosoma mansoni	serine/threonine protein kinase	0.0088	0.1406	0.2484
Brugia malayi	CHE-14 protein	0.0061	0.0932	0.1608
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0118	0.1917	0.3389
Loa Loa (eye worm)	hypothetical protein	0.002	0.0223	0.0349
Trypanosoma brucei	hypothetical protein, conserved	0.0026	0.0323	0.1199
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.002	0.0223	0.0349
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.006	0.006
Echinococcus multilocularis	RUN	0.0019	0.0204	0.0204
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0009	0.0034	0.0015
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0054	0.0818	0.2046
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0054	0.0818	0.1406
Loa Loa (eye worm)	hypothetical protein	0.0009	0.004	0.0025
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.002	0.0223	0.0349
Echinococcus granulosus	serine:threonine protein kinase MARK2	0.0088	0.1406	0.3516
Loa Loa (eye worm)	hypothetical protein	0.002	0.0223	0.0349
Echinococcus multilocularis	sterol regulatory element binding protein	0.0061	0.0932	0.0932
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.006	0.0106
Trichomonas vaginalis	CMGC family protein kinase	0.0118	0.1917	0.3389
Schistosoma mansoni	RAR-like nuclear receptor	0.002	0.0223	0.0394
Schistosoma mansoni	loxhd1	0.0019	0.0204	0.0361
Schistosoma mansoni	flap endonuclease-1	0.0012	0.0083	0.0147
Plasmodium falciparum	LCCL domain-containing protein	0.0019	0.0204	0.1065
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.002	0.0223	0.0349
Schistosoma mansoni	tar DNA-binding protein	0.0161	0.2663	0.4707
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0323	0.0527
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0223	0.0349
Loa Loa (eye worm)	hypothetical protein	0.002	0.0223	0.0349
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0011	0.006	0.006
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.001	0.0045	0.0112
Brugia malayi	conserved hypotetical protein	0.0009	0.004	0.0025
Onchocerca volvulus	Bile acid receptor homolog	0.002	0.0223	0.104
Mycobacterium leprae	Probable lipase LipE	0.0026	0.0323	0.5
Schistosoma mansoni	zinc finger protein	0.0009	0.004	0.0071
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0204	0.0511
Echinococcus granulosus	ecdysone induced protein 78C	0.002	0.0223	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0323	0.0527
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.002	0.0223	0.0394
Trichomonas vaginalis	penicillin-binding protein, putative	0.0026	0.0323	0.057
Schistosoma mansoni	coup transcription factor	0.002	0.0223	0.0394
Schistosoma mansoni	polycystin 1-related	0.0019	0.0204	0.0361
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0009	0.004	0.0074
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0204	0.0511
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.002	0.0223	0.0394
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0.1917	0.821
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.002	0.0223	0.0349
Plasmodium vivax	protein kinase Crk2	0.0054	0.0818	0.4267
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0142	0.2335	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0164	0.0289
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0054	0.0818	0.1406
Echinococcus multilocularis	Polycystic kidney disease protein	0.0019	0.0204	0.0204
Toxoplasma gondii	patched family protein	0.0009	0.0026	0.0136
Trichomonas vaginalis	D-aminoacylase, putative	0.0026	0.0323	0.057
Echinococcus granulosus	cyclin dependent kinase 1	0.0054	0.0818	0.2046
Echinococcus granulosus	nuclear receptor nhr 48	0.0009	0.004	0.0101
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0009	0.0034	0.0015
Brugia malayi	hypothetical protein	0.0117	0.191	0.3345
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0932	0.1647
Plasmodium vivax	flap endonuclease 1, putative	0.0013	0.0105	0.055
Echinococcus granulosus	netrin receptor unc 5	0.0017	0.0164	0.041
Trichomonas vaginalis	CAMK family protein kinase	0.0039	0.0561	0.0991
Schistosoma mansoni	nuclear receptor	0.0009	0.004	0.0071
Brugia malayi	protein unc-22	0.0009	0.0034	0.0015
Brugia malayi	Uncoordinated protein 44	0.0017	0.0164	0.0244
Brugia malayi	nuclear hormone receptor family member odr-7	0.0009	0.004	0.0025
Plasmodium falciparum	flap endonuclease 1	0.0013	0.0105	0.055
Loa Loa (eye worm)	hypothetical protein	0.0011	0.006	0.006
Brugia malayi	glutaminase DH11.1	0.0333	0.5658	1
Schistosoma mansoni	nuclear receptor nhr-48	0.0009	0.004	0.0071
Echinococcus multilocularis	tar DNA binding protein	0.0161	0.2663	0.2663
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0009	0.004	0.0101
Loa Loa (eye worm)	hypothetical protein	0.002	0.0223	0.0349
Leishmania major	hypothetical protein, conserved	0.0018	0.0189	0.0462
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0118	0.1917	0.3358
Brugia malayi	beta-lactamase family protein	0.0026	0.0323	0.0527
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0009	0.004	0.0071
Echinococcus multilocularis	netrin receptor unc 5	0.0017	0.0164	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0011	0.006	0.006
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0011	0.006	0.015
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.1033	0.1825
Brugia malayi	hypothetical protein	0.0009	0.004	0.0025
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.0769	0.136
Loa Loa (eye worm)	latrophilin receptor protein 2	0.001	0.0045	0.0033
Onchocerca volvulus		0.0009	0.004	0.0074
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0053	0.0793	0.1984
Brugia malayi	tailless protein	0.0009	0.004	0.0025
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.002	0.0223	0.0557
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0009	0.004	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0011	0.006	0.006
Brugia malayi	nuclear hormone receptor	0.002	0.0223	0.0349
Echinococcus granulosus	serine:threonine protein kinase	0.0051	0.0769	0.1924
Schistosoma mansoni	rab6-interacting	0.0019	0.0204	0.0361
Onchocerca volvulus		0.0009	0.004	0.0074
Schistosoma mansoni	titin	0.0009	0.0034	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0166	0.0249
Echinococcus granulosus	tar DNA binding protein	0.0161	0.2663	0.6661
Loa Loa (eye worm)	hypothetical protein	0.0011	0.006	0.006
Echinococcus granulosus	flap endonuclease 1	0.0013	0.0105	0.0264
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0118	0.1917	0.1917
Echinococcus granulosus	cyclin dependent kinase 5	0.0054	0.0818	0.2046
Echinococcus granulosus	Niemann Pick C1 protein	0.0142	0.2335	0.5841
Brugia malayi	Nuclear hormone receptor-like 1	0.002	0.0223	0.0349
Giardia lamblia	Kinase, CMGC CDK	0.0054	0.0818	0.4267
Loa Loa (eye worm)	hypothetical protein	0.002	0.0223	0.0349
Schistosoma mansoni	tar DNA-binding protein	0.0161	0.2663	0.4707
Echinococcus multilocularis	GPCR, family 2	0.001	0.0045	0.0045
Echinococcus multilocularis	myosin light chain kinase, smooth muscle	0.0238	0.3998	0.3998
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.1033	0.1331
Echinococcus granulosus	thyroid hormone receptor alpha	0.0009	0.004	0.0101
Schistosoma mansoni	serine/threonine protein kinase	0.0009	0.0034	0.0061
Trypanosoma cruzi	cdc2-related kinase 3	0.0054	0.0818	0.3934
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0223	0.0557
Giardia lamblia	Kinase, CMGC CDK	0.0054	0.0818	0.4267
Echinococcus multilocularis	serine:threonine protein kinase MARK2	0.0088	0.1406	0.1406
Echinococcus granulosus	Niemann Pick C1 protein	0.0203	0.339	0.8479
Brugia malayi	hypothetical protein	0.0012	0.0078	0.0093
Trypanosoma cruzi	cdc2-related kinase 1	0.0054	0.0818	0.3934
Plasmodium falciparum	ataxin-2 like protein, putative	0.0018	0.0189	0.0986
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0026	0.0323	0.0527
Schistosoma mansoni	hypothetical protein	0.0008	0.0017	0.003
Brugia malayi	orphan nuclear receptor NR2E1	0.0009	0.004	0.0025
Brugia malayi	nuclear receptor NHR-88	0.0009	0.004	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0009	0.004	0.0025
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.002	0.0223	0.0349
Trichomonas vaginalis	D-aminoacylase, putative	0.0026	0.0323	0.057
Trichomonas vaginalis	D-aminoacylase, putative	0.0026	0.0323	0.057
Loa Loa (eye worm)	CAMK protein kinase	0.0009	0.0034	0.0015
Trypanosoma cruzi	hypothetical protein, conserved	0.0026	0.0323	0.1199
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.001	0.0045	0.0033
Toxoplasma gondii	patched family protein	0.0009	0.0026	0.0136
Entamoeba histolytica	cell division protein kinase 2, putative	0.0054	0.0818	0.3503
Schistosoma mansoni	hypothetical protein	0.0037	0.0514	0.0908
Toxoplasma gondii	LsmAD domain-containing protein	0.0018	0.0189	0.0986
Echinococcus multilocularis	calcium activated potassium channel	0.0039	0.0561	0.0561
Brugia malayi	beta-lactamase	0.0026	0.0323	0.0527
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.002	0.0223	0.0557
Schistosoma mansoni	hypothetical protein	0.0037	0.0514	0.0908
Trypanosoma cruzi	PAB1-binding protein , putative	0.0018	0.0189	0.0462
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0145	0.2387	0.2387
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0011	0.006	0.0106
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0223	0.0349
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0031	0.0407	0.0677
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0009	0.004	0.0025
Echinococcus granulosus	calcium activated potassium channel	0.0039	0.0561	0.1403
Onchocerca volvulus	Protein ultraspiracle homolog	0.002	0.0223	0.104
Loa Loa (eye worm)	hypothetical protein	0.0009	0.004	0.0025
Toxoplasma gondii	aldehyde dehydrogenase	0.0067	0.1033	0.5387
Echinococcus granulosus	RUN	0.0019	0.0204	0.0511
Loa Loa (eye worm)	hypothetical protein	0.0009	0.004	0.0025
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0818	0.1446
Trypanosoma brucei	PAB1-binding protein , putative	0.0018	0.0189	0.0462
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0818	0.1446
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0189	0.0289
Loa Loa (eye worm)	CAMK/CAMKL/MELK protein kinase	0.0039	0.0561	0.0949
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0067	0.1033	0.5119
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0008	0.0017	0.0043
Brugia malayi	beta-lactamase family protein	0.0026	0.0323	0.0527
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0118	0.1917	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0026	0.0323	0.057
Echinococcus granulosus	expressed conserved protein	0.0133	0.2186	0.5468
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0017	0.0164	0.0244
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0067	0.1033	0.2583
Loa Loa (eye worm)	hypothetical protein	0.002	0.0223	0.0349
Echinococcus multilocularis	nuclear receptor nhr 48	0.0009	0.004	0.004
Trypanosoma cruzi	PAB1-binding protein , putative	0.0018	0.0189	0.0462
Schistosoma mansoni	thyroid hormone receptor	0.0165	0.2733	0.4831
Schistosoma mansoni	hypothetical protein	0.0059	0.0894	0.158
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0009	0.004	0.0101
Echinococcus granulosus	beta LACTamase domain containing family member	0.0026	0.0323	0.0807
Echinococcus multilocularis	cyclin dependent kinase	0.0054	0.0818	0.0818
Schistosoma mansoni	lipoxygenase	0.0019	0.0204	0.0361
Loa Loa (eye worm)	steroid hormone receptor	0.002	0.0223	0.0349
Echinococcus multilocularis	expressed conserved protein	0.0133	0.2186	0.2186
Echinococcus granulosus	Protein patched homolog 1	0.0061	0.0932	0.2331
Brugia malayi	RNA binding protein	0.0161	0.2663	0.4682
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0145	0.2387	0.5971
Schistosoma mansoni	glutaminase	0.0333	0.5658	1
Brugia malayi	hypothetical protein	0.0018	0.0189	0.0289
Brugia malayi	Nuclear hormone receptor E75	0.0009	0.004	0.0025
Trypanosoma brucei	cdc2-related kinase 3	0.0054	0.0818	0.3934
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.002	0.0223	0.0394
Loa Loa (eye worm)	glutaminase	0.0333	0.5658	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.004	0.0025
Brugia malayi	Nuclear hormone receptor E75	0.0009	0.004	0.0025
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0009	0.004	0.0101
Schistosoma mansoni	transcription factor LCR-F1	0.0026	0.0326	0.0577
Brugia malayi	TAR-binding protein	0.0161	0.2663	0.4682
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0771	0.1322
Trichomonas vaginalis	penicillin-binding protein, putative	0.0026	0.0323	0.057
Brugia malayi	nuclear receptor NHR-88	0.002	0.0223	0.0349
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0223	0.0223
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0054	0.0818	0.1406
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0009	0.004	0.0025
Brugia malayi	latrophilin 2 splice variant baaae	0.0021	0.024	0.0379
Brugia malayi	hypothetical protein	0.0011	0.006	0.006
Echinococcus granulosus	geminin	0.0195	0.3256	0.8144
Loa Loa (eye worm)	hypothetical protein	0.0011	0.006	0.006
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0009	0.004	0.0071
Brugia malayi	nuclear receptor NHR-67	0.0009	0.004	0.0025
Entamoeba histolytica	protein kinase, putative	0.0118	0.1917	0.821
Loa Loa (eye worm)	hypothetical protein	0.002	0.0223	0.0349
Loa Loa (eye worm)	beta-lactamase	0.0026	0.0323	0.0527
Echinococcus granulosus	Polycystic kidney disease protein	0.0019	0.0204	0.0511
Onchocerca volvulus	Huntingtin homolog	0.0117	0.191	0.996
Schistosoma mansoni	tar DNA-binding protein	0.0161	0.2663	0.4707
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0223	0.0557
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.1033	0.1331
Loa Loa (eye worm)	hypothetical protein	0.0009	0.004	0.0025
Schistosoma mansoni	ankyrin 23/unc44	0.0017	0.0164	0.0289
Toxoplasma gondii	ABC1 family protein	0.0026	0.0323	0.1683
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0026	0.0326	0.0326
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.001	0.0045	0.0045
Brugia malayi	Protein kinase domain containing protein	0.0039	0.0561	0.0949
Schistosoma mansoni	hypothetical protein	0.001	0.0045	0.0079
Echinococcus multilocularis	flap endonuclease 1	0.0013	0.0105	0.0105
Onchocerca volvulus		0.002	0.0223	0.104
Giardia lamblia	Kinase, CMGC GSK	0.0118	0.1917	1
Onchocerca volvulus		0.0026	0.0323	0.1568
Echinococcus multilocularis	geminin	0.0195	0.3256	0.3256
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.002	0.0223	0.0349
Plasmodium vivax	ataxin-2 like protein, putative	0.0018	0.0189	0.0986
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0818	0.1446
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0009	0.004	0.004
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0013	0.0105	0.055
Brugia malayi	hypothetical protein	0.0019	0.0204	0.0316
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0009	0.004	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0009	0.004	0.0025
Brugia malayi	Latrophilin receptor protein 2	0.001	0.0045	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0932	0.1608
Schistosoma mansoni	serine/threonine protein kinase	0.0039	0.0561	0.0991
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0054	0.0818	0.3934
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0008	0.0017	0.0017
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0026	0.0323	0.0323
Plasmodium falciparum	lipid/sterol:H+ symporter	0.0009	0.0026	0.0136
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0223	0.0349
Loa Loa (eye worm)	doublecortin family protein	0.0019	0.0204	0.0316
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0009	0.004	0.004
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0011	0.006	0.006
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.002	0.0223	0.0349
Brugia malayi	hypothetical protein	0.0009	0.004	0.0025
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0161	0.2663	0.4682
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0017	0.0164	0.0244
Echinococcus granulosus	cyclin dependent kinase	0.0054	0.0818	0.2046
Loa Loa (eye worm)	RNA binding protein	0.0161	0.2663	0.4682
Onchocerca volvulus		0.0026	0.0323	0.1568
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0204	0.0204
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.006	0.006

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)		Binding affinity to human MARK1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human ERBB2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human PLK1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human MER at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human DRAK1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human CLK3 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human NEK6 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human ERBB4 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human FMS at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human IRR at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human CAMK1D at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human TGFBR1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human FGFR4 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human FYN at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human ADCK3 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human TYK2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human CSK at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human TNK1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human JNK1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human AMPKA1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human CAMK2A at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human MYT1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human LIMK2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human MSK2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human TESK1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human NEK9 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human MET at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human IGF1R at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human AKT2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human PDK1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human AKT3 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human CAMK1A at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human PAK1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human FLT1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human MSK1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human ALK4 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human LIMK1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human PCTAIRE1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human JAK2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human JAK1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human CLK4 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human AKT1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human ALK at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human FGFR3 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human YSK1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human EPHB2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human RSK2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human FES at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human EPHA6 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human FGFR1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human PAK5 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human CAMK1G at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human MNK2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human FLT3 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human ZAP70 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human ADCK4 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human TIE2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human ITK at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human FLT4 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human ULK3 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human QIK at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human EPHA7 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human P38A at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human NDR2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human P38G at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human EPHA4 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human BMX at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human CAMK2B at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human MARK4 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human EPHA2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human PAK4 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human PLK3 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human FRK at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human MST3 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human MARK2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human MAP3K5 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human DMPK1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human CAMK2D at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human KDR at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human PAK2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human RET at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human PAK6 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human BTK at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human AMPKA2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human PKACB at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human EPHB3 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human YANK3 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human INSR at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human FAK at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human FER at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human CK2A2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human CLK1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human STK33 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human HPK1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human AURA at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human CK1a2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human MST2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human PKN2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human CK1gamma1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human PRKX at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human PKCA at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human FGFR2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human AURB at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human BMPR1A at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human GSK3A at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human NEK7 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human KHS1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human TRKA at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human EGFR at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human TRKB at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human AXL at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human MST1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human PAK3 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human EPHB4 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human CAMK2G at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human RSK1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human JNK2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human TXK at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human TLK2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human PYK2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human ERK1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human GCN2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human TRKC at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human FUSED at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human MLK3 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human NEK2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human SRC at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human LYN at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human ERK2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human ROS at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human RSK4 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human PHKG1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)		Binding affinity to human PHKG2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 0.1 %	Binding affinity to human TLK1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 0.4 %	Binding affinity to human PIM2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 0.5 %	Binding affinity to human CDK2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 0.6 %	Binding affinity to human EPHA3 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 1.5 %	Binding affinity to human PLK4 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 1.5 %	Binding affinity to human TNIK at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 1.5 %	Binding affinity to human AAK1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 1.9 %	Binding affinity to human GAK at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 1.9 %	Binding affinity to human EPHB1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 2.6 %	Binding affinity to human NLK at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 2.6 %	Binding affinity to human SLK at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 2.8 %	Binding affinity to human DAPK3 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 3.6 %	Binding affinity to human DAPK2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 3.7 %	Binding affinity to human LKB1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 4.1 %	Binding affinity to human ARG at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 4.2 %	Binding affinity to human ACTR2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 4.6 %	Binding affinity to human ABL at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 5.3 %	Binding affinity to human PDGFRB at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 6.2 %	Binding affinity to human CLK2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 6.4 %	Binding affinity to human PDGFRA at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 6.55 %	Binding affinity to human BRSK2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 8.25 %	Binding affinity to human ALK2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 9.1 %	Binding affinity to human BIKE at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 10.6 %	Binding affinity to human CK1e at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 11 %	Binding affinity to human CAMKK1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 11.1 %	Binding affinity to human P38B at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 11.1 %	Binding affinity to human EPHA5 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 12.7 %	Binding affinity to human EPHA8 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 12.9 %	Binding affinity to human CK2A1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 13.4 %	Binding affinity to human SRPK1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 14.5 %	Binding affinity to human TTK at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 15.6 %	Binding affinity to human EPHA1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 16.8 %	Binding affinity to human SYK at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 17.2 %	Binding affinity to human CDK5 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 17.45 %	Binding affinity to human ALK1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 18.9 %	Binding affinity to human YANK2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 19 %	Binding affinity to human CK1d at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 19.6 %	Binding affinity to human LCK at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 20.3 %	Binding affinity to human DRAK2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 20.7 %	Binding affinity to human FGR at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 21.1 %	Binding affinity to human PIM1 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 21.4 %	Binding affinity to human HGK at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 21.6 %	Binding affinity to human RIPK2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 21.9 %	Binding affinity to human KIT at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 22.5 %	Binding affinity to human LOK at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 24.5 %	Binding affinity to human BRAF at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 25.3 %	Binding affinity to human JNK3 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 26.3 %	Binding affinity to human HCK at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 26.3 %	Binding affinity to human BLK at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 27 %	Binding affinity to human YES at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 28.1 %	Binding affinity to human TYRO3 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 29.7 %	Binding affinity to human AURC at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 35.4 %	Binding affinity to human CAMKK2 at 10 uM relative to control	ChEMBL.	19035792
Activity (binding)	= 35.6 %	Binding affinity to human RAF1 at 10 uM relative to control	ChEMBL.	19035792
IC50 (binding)	= 8 nM	Inhibition of GSK3-beta	ChEMBL.	19035792
IC50 (binding)	= 12 nM	Inhibitory concentration against glycogen synthase kinase-3 alpha	ChEMBL.	12941333
IC50 (binding)	= 12 nM	Inhibitory activity to human glycogen synthase kinase-3 alpha (GSK-3alpha) was determined	ChEMBL.	12941332
IC50 (binding)	= 12 nM	Inhibition of recombinant GSK3beta (unknown origin)	ChEMBL.	18324764
IC50 (binding)	= 12 nM	Inhibitory concentration against glycogen synthase kinase-3 alpha	ChEMBL.	12941333
IC50 (binding)	= 12 nM	Inhibitory activity to human glycogen synthase kinase-3 alpha (GSK-3alpha) was determined	ChEMBL.	12941332
IC50 (binding)	= 12 nM	Inhibition of recombinant GSK3beta (unknown origin)	ChEMBL.	18324764
IC50 (binding)	= 62 nM	Inhibitory concentration against cyclin-dependent kinase 2	ChEMBL.	12941333
IC50 (binding)	= 62 nM	Inhibitory concentration against cyclin-dependent kinase 2	ChEMBL.	12941333
Kd (binding)	= 16 nM	Binding affinity to human PIM2	ChEMBL.	19035792
Kd (binding)	= 150 nM	Binding affinity to human SKMLCK	ChEMBL.	19035792
Kd (binding)	= 207 nM	Binding affinity to human MARK1	ChEMBL.	19035792
Kd (binding)	> 40000 nM	Binding affinity to human MPSK1	ChEMBL.	19035792

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL408019
PubChem: 6539569

Bibliographic References

4 literature references were collected for this gene.

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Detailed information for compound 512157