Detailed information for compound 513621

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 524.61 | Formula: C31H32N4O4
  • H donors: 1 H acceptors: 3 LogP: 4.11 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N1CCc2c(C1)cccc2)COc1ccc(cc1)c1[nH]c2c(c1)n(CC1CC1)c(=O)n(c2=O)CC1CC1
  • InChi: 1S/C31H32N4O4/c36-28(33-14-13-22-3-1-2-4-24(22)18-33)19-39-25-11-9-23(10-12-25)26-15-27-29(32-26)30(37)35(17-21-7-8-21)31(38)34(27)16-20-5-6-20/h1-4,9-12,15,20-21,32H,5-8,13-14,16-19H2
  • InChiKey: SJVLZHJJIWSOJI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A2b receptor Starlite/ChEMBL References
Homo sapiens adenosine A2a receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi follicle stimulating hormone receptor adenosine A2a receptor 412 aa 336 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0033 0.0023 0.0021
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0049 0.038
Brugia malayi jmjC domain containing protein 0.0095 0.0084 0.0659
Brugia malayi Cytochrome P450 family protein 0.0022 0.0012 0.0082
Schistosoma mansoni tar DNA-binding protein 0.0102 0.0092 0.352
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0073 0.0062 0.0204
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0009 0.0053
Toxoplasma gondii exonuclease III APE 0.0033 0.0023 0.1324
Schistosoma mansoni hypothetical protein 0.009 0.008 0.3062
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0055 0.0045 0.0043
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Brugia malayi Cytochrome P450 family protein 0.0047 0.0037 0.0279
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0045 0.2209
Brugia malayi jmjC domain containing protein 0.0035 0.0025 0.0184
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0055 0.0045 0.2507
Entamoeba histolytica Rho family GTPase 0.0012 0.0002 0.0348
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0025 0.0023
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0043 0.0033 0.1213
Plasmodium falciparum importin beta, putative 0.0025 0.0015 0.0401
Echinococcus granulosus polycomb protein SCMH1 0.0036 0.0026 0.0024
Trypanosoma brucei importin beta-1 subunit, putative 0.0025 0.0015 0.0409
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0009 0.0262
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0055 0.0045 0.2209
Leishmania major cAMP-specific phosphodiesterase, putative 0.0265 0.0253 1
Mycobacterium ulcerans bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 0.0043 0.0033 0.0028
Entamoeba histolytica Ran family GTPase 0.0018 0.0009 0.1448
Leishmania major eukaryotic translation initiation factor-like 0.0069 0.0059 0.2187
Plasmodium falciparum orotate phosphoribosyltransferase 0.0043 0.0033 0.1484
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0033 0.0023 0.0018
Brugia malayi RNA binding protein 0.0102 0.0092 0.0718
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0033 0.0023 0.1324
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0084 0.0082
Mycobacterium leprae PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE (OPRT) (OPRTASE) 0.0043 0.0033 0.0099
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0055 0.0045 0.168
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0055 0.0045 0.0043
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0183 0.0173 0.6703
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.003 0.0028
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0147 0.0137 0.0135
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0045 0.2596
Echinococcus granulosus histone acetyltransferase MYST2 0.0041 0.0031 0.0029
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0045 0.2507
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0045 0.2507
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0055 0.0045 0.0043
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0041 0.0031 0.0029
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0009 0.0053
Schistosoma mansoni hypothetical protein 0.0224 0.0213 0.8282
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0055 0.0045 0.1702
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0041 0.0031 0.0029
Schistosoma mansoni ap endonuclease 0.0033 0.0023 0.0817
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0069 0.0059 0.0057
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0043 0.0033 0.1213
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0069 0.0059 0.3357
Schistosoma mansoni ap endonuclease 0.0033 0.0023 0.0817
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0009 0.0292
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0042 0.2407
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0069 0.0059 0.2279
Schistosoma mansoni cell polarity protein 0.0135 0.0125 0.4823
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0018 0.0009 0.0498
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0045 0.1702
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.2844 0.2816 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0042 0.1472
Echinococcus granulosus SAM and MBT domain containing protein 0.0036 0.0026 0.0024
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0009 0.0007
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0268 0.0256 0.2039
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0009 0.0262
Brugia malayi hypothetical protein 0.0052 0.0042 0.0316
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0053
Loa Loa (eye worm) TAR-binding protein 0.0102 0.0092 0.0718
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0018 0.0009 0.0144
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0009 0.0262
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0009 0.0059
Brugia malayi exodeoxyribonuclease III family protein 0.0033 0.0023 0.0167
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0012 0.0409
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Mycobacterium tuberculosis Probable pyrimidine operon regulatory protein PyrR 0.0043 0.0033 0.0028
Plasmodium vivax phosphodiesterase gamma, putative 0.0055 0.0045 0.2596
Trichomonas vaginalis Importin beta-1 subunit, putative 0.002 0.001 0.0492
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0183 0.0173 0.017
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0009 0.0059
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0045 0.2596
Leishmania major eukaryotic translation initiation factor-like protein 0.0069 0.0059 0.2187
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0153 0.0142 0.5499
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.003 0.109
Mycobacterium leprae Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho 0.0141 0.013 0.0444
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0183 0.0173 0.6751
Mycobacterium ulcerans hypothetical protein 0.0043 0.0033 0.0028
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0153 0.0142 0.5518
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0055 0.0045 0.1603
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0055 0.0045 0.0343
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0033 0.0028
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0183 0.0173 0.017
Leishmania major cytochrome p450-like protein 0.0022 0.0012 0.0295
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0009 0.0053
Schistosoma mansoni hypothetical protein 0.0029 0.0019 0.0664
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.008 0.007 0.0065
Loa Loa (eye worm) hypothetical protein 0.005 0.0039 0.03
Loa Loa (eye worm) hypothetical protein 0.0055 0.0045 0.0343
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0009 0.0007
Brugia malayi PXA domain containing protein 0.0019 0.0009 0.0053
Schistosoma mansoni sex comb on midleg homolog 0.0036 0.0026 0.0931
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0045 0.1603
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0084 0.0082
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0049 0.0044
Mycobacterium ulcerans thymidine phosphorylase 1.0075 1 1
Plasmodium falciparum phd finger protein, putative 0.0029 0.0019 0.0632
Brugia malayi GTP-binding protein 0.0135 0.0125 0.0983
Entamoeba histolytica Rho family GTPase 0.0012 0.0002 0.0348
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0139 0.0128 0.5034
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0139 0.0128 0.7445
Echinococcus multilocularis peregrin 0.0029 0.0019 0.0017
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0153 0.0142 0.014
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0009 0.0007
Brugia malayi GTP-binding protein, identical 0.0135 0.0125 0.0983
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0043 0.0033 0.1229
Echinococcus multilocularis geminin 0.009 0.008 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0391
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0045 0.2596
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0043 0.0033 0.1229
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0005 0.0003
Mycobacterium tuberculosis Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase) 0.0043 0.0033 0.0028
Toxoplasma gondii HEAT repeat-containing protein 0.0025 0.0015 0.0879
Treponema pallidum hypothetical protein 0.0043 0.0033 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0033 0.0023 0.0021
Echinococcus multilocularis histone acetyltransferase MYST2 0.0041 0.0031 0.0029
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0009 0.0007
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0055 0.0045 0.2596
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0009 0.0007
Giardia lamblia hypothetical protein 0.0055 0.0045 0.2507
Loa Loa (eye worm) hypothetical protein 0.0025 0.0015 0.0105
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0045 0.1702
Brugia malayi Phosphoribosyl transferase domain containing protein 0.0183 0.0173 0.1367
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0153 0.0142 0.1121
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0139 0.0128 0.4975
Echinococcus multilocularis adenine phosphoribosyltransferase 0.0043 0.0033 0.0031
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0009 0.0007
Loa Loa (eye worm) mbt repeat family protein 0.0036 0.0026 0.019
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0045 0.2596
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0045 0.2507
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0391
Mycobacterium tuberculosis Adenine phosphoribosyltransferase Apt (APRT) (AMP diphosphorylase) (AMP pyrophosphorylase) (transphosphoribosidase) 0.0043 0.0033 0.0028
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0055 0.0045 0.168
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0055 0.0045 0.1702
Mycobacterium tuberculosis Conserved protein 0.0043 0.0033 0.0028
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0045 0.2596
Echinococcus granulosus tar DNA binding protein 0.0102 0.0092 0.009
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0069 0.0059 0.2187
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0033 0.0023 0.0719
Echinococcus multilocularis importin subunit beta 1 0.0025 0.0015 0.0013
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0009 0.043
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0062 0.0052 0.2925
Brugia malayi Adenine phosphoribosyltransferase 0.0043 0.0033 0.0247
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0037 0.0279
Loa Loa (eye worm) GMP reductase 0.0063 0.0053 0.0411
Brugia malayi PHD-finger family protein 0.0029 0.0019 0.0135
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0069 0.0059 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Schistosoma mansoni DNA helicase recq5 0.0019 0.0009 0.0288
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0019 0.1098
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0055 0.0045 0.1702
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0009 0.0007
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0009 0.0177
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0042 0.201
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0005 0.0117
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0043 0.0033 0.1229
Brugia malayi RNA recognition motif domain containing protein 0.0102 0.0092 0.0718
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0069 0.0059 0.3436
Echinococcus granulosus ras gtpase 0.0135 0.0125 0.0123
Trichomonas vaginalis ap endonuclease, putative 0.0033 0.0023 0.122
Schistosoma mansoni cell polarity protein 0.0135 0.0125 0.4823
Schistosoma mansoni hypothetical protein 0.0015 0.0005 0.0116
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0139 0.0128 0.1013
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0045 0.2507
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.0135
Loa Loa (eye worm) hypothetical protein 0.0055 0.0045 0.0343
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0265 0.0253 1
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0153 0.0142 0.0137
Entamoeba histolytica hypothetical protein 0.0019 0.0009 0.1565
Giardia lamblia PHD finger protein 15 0.0029 0.0019 0.099
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Trypanosoma brucei GMP reductase 0.0153 0.0142 0.5518
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0019 0.0017
Loa Loa (eye worm) hypothetical protein 0.0036 0.0026 0.019
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0009 0.0262
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0018 0.0009 0.0383
Leishmania major GTP-binding protein, putative 0.0018 0.0009 0.0144
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0009 0.043
Loa Loa (eye worm) RecQ helicase 0.0019 0.0009 0.0059
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase, putative 0.0183 0.0173 1
Echinococcus granulosus peregrin 0.0029 0.0019 0.0017
Schistosoma mansoni survival motor neuron protein 0.0047 0.0037 0.1365
Brugia malayi translation initiation factor 4E 0.0069 0.0059 0.0459
Schistosoma mansoni ran 0.0018 0.0009 0.0257
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0049 0.1839
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0009 0.0053
Trypanosoma brucei hypothetical protein, conserved 0.0055 0.0045 0.1603
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0009 0.0007
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase, putative 0.0183 0.0173 0.6751
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0045 0.1603
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0012 0.0007
Brugia malayi Cytochrome P450 family protein 0.0022 0.0012 0.0082
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0102 0.0092 0.0718
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0055 0.0045 0.0343
Plasmodium falciparum phosphodiesterase delta, putative 0.0055 0.0045 0.2209
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0069 0.0059 0.3357
Brugia malayi RNA, U transporter 1 0.0071 0.0061 0.0474
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0055 0.0045 0.0043
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0049 0.1839
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0069 0.0059 0.3357
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0055 0.0045 0.0043
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0009 0.0262
Leishmania major hypothetical protein, conserved 0.0055 0.0045 0.1603
Echinococcus granulosus expressed protein 0.0362 0.035 0.0348
Giardia lamblia Adenine phosphoribosyltransferase 0.0043 0.0033 0.181
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0045 0.1702
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0033 0.0023 0.122
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0019 0.1098
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0055 0.0045 0.0043
Schistosoma mansoni tar DNA-binding protein 0.0102 0.0092 0.352
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0139 0.0128 0.0126
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0144 0.0133 0.0128
Mycobacterium leprae AMIDOPHOSPHORIBOSYLTRANSFERASE PURF (GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE) (ATASE) (GPATASE) 0.0043 0.0033 0.0099
Giardia lamblia Guanine phosphoribosyltransferase 0.0183 0.0173 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0045 0.2596
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0012 0.0409
Onchocerca volvulus 0.0047 0.0037 0.2036
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0012 0.0082
Treponema pallidum adenine phosphoribosyltransferase 0.0043 0.0033 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0053
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0025 0.0184
Schistosoma mansoni hypothetical protein 0.0023 0.0013 0.044
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0053
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0139 0.0128 0.4975
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0025 0.0073
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0049 0.0044
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0033 0.0023 0.087
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0018 0.0009 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.003 0.109
Echinococcus multilocularis polycomb protein SCMH1 0.0036 0.0026 0.0024
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0144 0.0133 0.7584
Schistosoma mansoni hypothetical protein 0.0019 0.0009 0.0284
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0033 0.0023 0.0719
Echinococcus granulosus GTP binding nuclear protein Ran 0.0018 0.0009 0.0007
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0183 0.0173 0.6789
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0019 0.0009 0.0007
Loa Loa (eye worm) translation initiation factor 4E 0.0069 0.0059 0.0459
Schistosoma mansoni sex comb on midleg homolog 0.0036 0.0026 0.0931
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.2844 0.2816 0.2812
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0055 0.0045 0.0043
Echinococcus multilocularis thymidine phosphorylase 1.0075 1 1
Echinococcus multilocularis tar DNA binding protein 0.0102 0.0092 0.009
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0153 0.0142 0.557
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0055 0.0045 0.2507
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0049 0.0047
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Entamoeba histolytica hypothetical protein 0.002 0.001 0.1763
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0183 0.0173 0.6789
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0045 0.2596
Schistosoma mansoni tar DNA-binding protein 0.0102 0.0092 0.352
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0055 0.0045 0.0343
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0055 0.0045 0.0343
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0009 0.0007
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0009 0.0262
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0055 0.0045 0.0043
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0013 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0009 0.0262
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0055 0.0045 0.2507
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0018 0.0009 0.026
Treponema pallidum phosphoribosylpyrophosphate synthetase 0.0043 0.0033 1
Giardia lamblia Hypothetical protein 0.0055 0.0045 0.2507
Onchocerca volvulus Putative GMP reductase 0.0063 0.0053 0.3004
Trypanosoma cruzi importin beta-1 subunit, putative 0.002 0.001 0.0334
Schistosoma mansoni hypothetical protein 0.0047 0.0037 0.1365
Loa Loa (eye worm) GTP-binding protein 0.0135 0.0125 0.0983
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0009 0.043
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0055 0.0045 0.2507
Echinococcus multilocularis expressed protein 0.0362 0.035 0.0348
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0025 0.0901
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.003 0.0028
Loa Loa (eye worm) orotate phosphoribosyltransferase 0.0043 0.0033 0.0247
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0019 0.0017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.003 0.0028
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0009 0.0007
Echinococcus multilocularis ras gtpase 0.0135 0.0125 0.0123
Mycobacterium ulcerans adenine phosphoribosyltransferase 0.0043 0.0033 0.0028
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0018 0.0009 0.0052
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0009 0.0007
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0009 0.0007
Echinococcus granulosus geminin 0.009 0.008 0.0078
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0009 0.0007
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0045 0.2507
Leishmania major inosine-5-monophosphate dehydrogenase 0.0153 0.0142 0.5518
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0055 0.0045 0.1702
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0063 0.0053 0.0411
Mycobacterium tuberculosis Conserved protein 0.0043 0.0033 0.0028
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0045 0.2596
Leishmania major xanthine phosphoribosyltransferase 0.0183 0.0173 0.6751
Wolbachia endosymbiont of Brugia malayi orotate phosphoribosyltransferase 0.0043 0.0033 0.0845
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0055 0.0045 0.168
Echinococcus granulosus survival motor neuron protein 1 0.023 0.0218 0.0216
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0144 0.0133 0.7704
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0009 0.0059
Entamoeba histolytica hypothetical protein 0.0019 0.0009 0.1565
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0009 0.043
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0045 0.2507
Onchocerca volvulus Alhambra homolog 0.0029 0.0019 0.099
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0265 0.0253 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0045 0.2507
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0153 0.0142 0.557
Brugia malayi hypothetical protein 0.0019 0.0009 0.0053
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0045 0.2596
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0043 0.0033 0.1229
Loa Loa (eye worm) adenine phosphoribosyltransferase 0.0043 0.0033 0.0247
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0009 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0045 0.2507
Brugia malayi hypothetical protein 0.0019 0.0009 0.0058
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0139 0.0128 0.5034
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0042 0.2407
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Trypanosoma brucei Adenine phosphoribosyltransferase, putative 0.0043 0.0033 0.1125
Echinococcus granulosus bloom syndrome protein 0.0019 0.0009 0.0007
Brugia malayi mbt repeat family protein 0.0036 0.0026 0.019
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0055 0.0045 0.1702
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0018 0.0009 0.0052
Brugia malayi Cytochrome P450 family protein 0.0015 0.0005 0.0024
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0073 0.0062 0.0057
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0009 0.0053
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Brugia malayi hypothetical protein 0.023 0.0218 0.1734
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0055 0.0045 0.1603
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0183 0.0173 0.017
Leishmania major guanosine monophosphate reductase 0.0153 0.0142 0.5518
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0025 0.0023
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0468 0.0455 0.0453
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0139 0.0128 0.497
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0153 0.0142 0.014
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0055 0.0045 0.0043
Loa Loa (eye worm) PDE1B protein 0.0139 0.0128 0.1013
Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT 0.0183 0.0173 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0009 0.0007
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0055 0.0045 0.2209
Leishmania major orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative 0.0043 0.0033 0.1125
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0153 0.0142 0.0137
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0153 0.0142 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0009 0.0049
Echinococcus granulosus uridine 5' monophosphate synthase 0.0043 0.0033 0.0031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.003 0.109
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0025 0.0901
Entamoeba histolytica Rho family GTPase 0.0012 0.0002 0.0348
Loa Loa (eye worm) hypothetical protein 0.023 0.0218 0.1734
Loa Loa (eye worm) RNA binding protein 0.0102 0.0092 0.0718
Entamoeba histolytica hypothetical protein 0.0019 0.0009 0.1473
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Entamoeba histolytica hypothetical protein 0.0019 0.0009 0.1565
Loa Loa (eye worm) hypothetical protein 0.1212 0.1195 0.9563
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0018 0.0009 0.026
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0009 0.0007
Plasmodium vivax importin-beta 2, putative 0.0025 0.0015 0.0879
Echinococcus multilocularis 0.0015 0.0005 0.0003
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.1267 0.1249 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0045 0.2596
Loa Loa (eye worm) hypothetical protein 0.0055 0.0045 0.0343
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0065 0.2472
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0009 0.0053
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0055 0.0045 0.168
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0055 0.0045 0.2507
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0009 0.0053
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0059
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0043 0.0033 0.1213
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0183 0.0173 0.6751
Leishmania major hypoxanthine-guanine phosphoribosyltransferase 0.0183 0.0173 0.6751
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0025 0.002
Onchocerca volvulus 0.0036 0.0026 0.1389
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0009 0.0049
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0139 0.0128 0.0126
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0045 0.2596
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0009 0.0007
Mycobacterium ulcerans orotate phosphoribosyltransferase 0.0043 0.0033 0.0028
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0015 0.0005 0.0117
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0055 0.0045 0.168
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0042 0.1572
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0019 0.0009 0.0007
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0041 0.0031 0.0229
Plasmodium vivax orotate phosphoribosyltransferase, putative 0.0043 0.0033 0.1908
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0033 0.0023 0.0828
Mycobacterium tuberculosis Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor 0.0141 0.013 0.0125
Schistosoma mansoni cytochrome P450 0.0015 0.0005 0.0116
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0018 0.0009 0.0498
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0009 0.0007
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0013 0.0011
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0045 0.2596
Loa Loa (eye worm) hypothetical protein 0.1267 0.1249 1
Entamoeba histolytica hypothetical protein 0.0019 0.0009 0.1473
Echinococcus granulosus jumonji domain containing protein 0.004 0.003 0.0028
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0009 0.0053
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0053
Leishmania major adenine phosphoribosyltransferase 0.0043 0.0033 0.1125
Echinococcus granulosus importin subunit beta 1 0.0025 0.0015 0.0013
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0063 0.0053 0.0411
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0009 0.0007
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0033 0.0023 0.3854
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0055 0.0045 0.0043
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0069 0.0059 0.3357
Echinococcus granulosus snurportin 1 0.0268 0.0256 0.0254
Entamoeba histolytica Rho family GTPase 0.0012 0.0002 0.0348
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0045 0.2209
Schistosoma mansoni tar DNA-binding protein 0.0102 0.0092 0.352
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0009 0.1584
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0009 0.0007
Echinococcus multilocularis uridine 5' monophosphate synthase 0.0043 0.0033 0.0031
Entamoeba histolytica hypothetical protein 0.0019 0.0009 0.1473
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0183 0.0173 0.6703
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0009 0.0262
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0009 0.0053
Loa Loa (eye worm) MBCTL1 0.0041 0.0031 0.0229
Brugia malayi PXA domain containing protein 0.0019 0.0009 0.0053
Trichomonas vaginalis Ribose-phosphate pyrophosphokinase, putative 0.0043 0.0033 0.181
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0139 0.0128 0.7445
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.0218 0.0216
Schistosoma mansoni ran 0.0018 0.0009 0.0257
Echinococcus multilocularis snurportin 1 0.0268 0.0256 0.0254
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0042 0.1572
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0009 0.0007
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0009 0.0262
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.2844 0.2816 0.2812
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0049 0.0044
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0183 0.0173 0.6789
Schistosoma mansoni orotidine 5'-phosphate decarboxylase 0.0043 0.0033 0.1213
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0009 0.0262
Brugia malayi Importin beta-1 subunit 0.0025 0.0015 0.0105
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0045 0.2596
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0019 0.0664
Trichomonas vaginalis hypoxanthine-guanine phosphoribosyltransferase, putative 0.0183 0.0173 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0049 0.0044
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0139 0.0128 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0391
Trypanosoma cruzi GMP reductase 0.0153 0.0142 0.557
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0045 0.1702
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0055 0.0045 0.0043
Schistosoma mansoni tar DNA-binding protein 0.0102 0.0092 0.352
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0055 0.0045 0.2507
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0012 0.0082
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0153 0.0142 0.0487
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0009 0.0391
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0045 0.2596
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0139 0.0128 0.7445
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0183 0.0173 0.017
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0045 0.2596
Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase 0.0183 0.0173 1
Trypanosoma brucei Adenine phosphoribosyltransferase, putative 0.0043 0.0033 0.1125
Schistosoma mansoni hypothetical protein 0.0268 0.0256 1
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0043 0.0033 0.1229
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0391
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0069 0.0059 0.2187
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0009 0.0007
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0055 0.0045 0.168
Loa Loa (eye worm) hypothetical protein 0.0041 0.0031 0.0229
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0153 0.0142 0.557
Brugia malayi hypothetical protein 0.0033 0.0023 0.0171
Trichomonas vaginalis ribose-phosphate pyrophosphokinase, putative 0.0043 0.0033 0.181
Trypanosoma cruzi GMP reductase 0.0153 0.0142 0.557
Brugia malayi GMP reductase 0.0063 0.0053 0.0411
Trypanosoma brucei orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0043 0.0033 0.1125
Schistosoma mansoni importin beta-1 0.0025 0.0015 0.0515
Brugia malayi orotate phosphoribosyltransferase family protein 0.0043 0.0033 0.0247
Toxoplasma gondii cytochrome p450 superfamily protein 0.0015 0.0005 0.029
Onchocerca volvulus 0.0183 0.0173 1
Leishmania major hypothetical protein, conserved 0.0052 0.0042 0.1472
Schistosoma mansoni myelin transcription factor 1 myt1 0.0041 0.0031 0.1125
Entamoeba histolytica Rho family GTPase 0.0012 0.0002 0.0348
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0069 0.0059 1
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0069 0.0059 0.2279
Echinococcus multilocularis jumonji domain containing protein 0.004 0.003 0.0028
Loa Loa (eye worm) IMP dehydrogenase 1 0.0153 0.0142 0.1121
Echinococcus multilocularis SAM and MBT domain containing protein 0.0036 0.0026 0.0024
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.008 0.007 0.0231
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0049 0.283
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0045 0.2596
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0033 0.0023 0.0018
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0036 0.0026 0.1389
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0045 0.2507
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.003 0.0028
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0009 0.0177
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0055 0.0045 0.168
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0069 0.0059 0.225
Mycobacterium ulcerans amidophosphoribosyltransferase 0.0043 0.0033 0.0028
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0055 0.0045 0.2507
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0009 0.0007
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0025 0.0073
Toxoplasma gondii orotate phosphoribosyltransferase 0.0043 0.0033 0.1908
Trichomonas vaginalis ap endonuclease, putative 0.0033 0.0023 0.122
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Trichomonas vaginalis ran, putative 0.0018 0.0009 0.0383
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0055 0.0045 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0045 0.1702
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0139 0.0128 0.0126
Brugia malayi mbt repeat family protein 0.0036 0.0026 0.019
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0055 0.0045 0.2507
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0055 0.0045 0.2507
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0391
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0043 0.0033 0.1229
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0025 0.002
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0049 0.1766
Mycobacterium tuberculosis Amidophosphoribosyltransferase PurF (glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (gpatase) 0.0043 0.0033 0.0028
Schistosoma mansoni uracil phosphoribosyltransferase 0.0043 0.0033 0.1213
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0009 0.0262
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0069 0.0059 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0009 0.0391
Leishmania major hypothetical protein, conserved 0.0055 0.0045 0.1603
Schistosoma mansoni hypothetical protein 0.009 0.008 0.3062
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0005 0.0117
Entamoeba histolytica Rho family GTPase 0.0012 0.0002 0.0348
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0045 0.1702
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0037 0.0278
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0009 0.0007
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0009 0.0544
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0033 0.0023 0.0828
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0042 0.201
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Toxoplasma gondii IMP dehydrogenas 0.0153 0.0142 0.8226
Plasmodium falciparum phosphodiesterase gamma, putative 0.0055 0.0045 0.2209
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0009 0.0053
Wolbachia endosymbiont of Brugia malayi amidophosphoribosyltransferase 0.0043 0.0033 0.0845
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0049 0.0047
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0009 0.0007
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0055 0.0045 0.168
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0019 0.0135
Brugia malayi cytochrome P450 0.0015 0.0005 0.0024
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 1.0075 1 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0012 0.0082
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0019 0.1098
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0055 0.0045 0.168
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0009 0.0059
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0053
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0033 0.0023 0.0167
Trichomonas vaginalis Importin beta-1 subunit, putative 0.002 0.001 0.0492
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0055 0.0045 0.168
Onchocerca volvulus Adenine phosphoribosyltransferase homolog 0.0043 0.0033 0.181
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0055 0.0045 0.0343
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0055 0.0045 0.2507
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0009 0.0053
Brugia malayi TAR-binding protein 0.0102 0.0092 0.0718
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0183 0.0173 0.6789
Trypanosoma brucei importin beta-1 subunit, putative 0.0025 0.0015 0.0409
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0055 0.0045 0.2596
Schistosoma mansoni transcription factor LCR-F1 0.0019 0.0009 0.0284
Echinococcus granulosus adenine phosphoribosyltransferase 0.0043 0.0033 0.0031
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.004 0.003 0.0222
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0036 0.0026 0.0931
Schistosoma mansoni DNA helicase recq1 0.0019 0.0009 0.0288
Entamoeba histolytica hypothetical protein 0.0019 0.0009 0.1565
Leishmania major importin beta-1 subunit, putative 0.002 0.001 0.0219
Brugia malayi Bromodomain containing protein 0.0029 0.0019 0.0135
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0147 0.0137 0.0135
Loa Loa (eye worm) cytochrome P450 0.0015 0.0005 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0009 0.0262
Brugia malayi hypothetical protein 0.0019 0.0009 0.0053
Mycobacterium ulcerans hypoxanthine-guanine phosphoribosyltransferase Hpt 0.0183 0.0173 0.0168
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0043 0.0033 0.1213
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0012 0.0295
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0045 0.2507
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0055 0.0045 0.2507
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0009 0.0544
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.004 0.003 0.0222
Loa Loa (eye worm) hypothetical protein 0.0052 0.0042 0.0316
Trichomonas vaginalis importin beta-1, putative 0.002 0.001 0.0492
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0009 0.0262

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = -8.02 Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells ChEMBL. 18226909
Ki (binding) = -6.62 Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in CHO cells ChEMBL. 18226909
Log Ki (binding) Displacement of [3H]NECA from human adenosine A3 receptor expressed in CHO cells ChEMBL. 18226909
Log Ki (binding) Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells ChEMBL. 18226909
Log Ki (binding) 0 Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells ChEMBL. 18226909
Log Ki (binding) 0 Displacement of [3H]NECA from human adenosine A3 receptor expressed in CHO cells ChEMBL. 18226909
Log Ki (binding) = 6.62 Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in CHO cells ChEMBL. 18226909
Log Ki (binding) = 8.02 Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cells ChEMBL. 18226909
Ratio (binding) = 25 Selectivity index, ratio for human adenosine A2A receptor to human adenosine A2B receptor ChEMBL. 18226909

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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