Detailed information for compound 517627

Basic information

Technical information
  • TDR Targets ID: 517627
  • Name: [(2S,3aS,7aS)-2,3,3a,4,5,6,7,7a-octahydro-1H- indol-2-yl]-[(2S)-2-(1,3-thiazole-2-carbonyl) pyrrolidin-1-yl]methanone
  • MW: 333.448 | Formula: C17H23N3O2S
  • H donors: 1 H acceptors: 3 LogP: 2.5 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCC[C@H]1C(=O)c1nccs1)[C@@H]1C[C@H]2[C@@H](N1)CCCC2
  • InChi: 1S/C17H23N3O2S/c21-15(16-18-7-9-23-16)14-6-3-8-20(14)17(22)13-10-11-4-1-2-5-12(11)19-13/h7,9,11-14,19H,1-6,8,10H2/t11-,12-,13-,14-/m0/s1
  • InChiKey: XCPMCXPDLRIOJO-XUXIUFHCSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [(2S,3aS,7aS)-2,3,3a,4,5,6,7,7a-octahydro-1H-indol-2-yl]-[(2S)-2-(thiazole-2-carbonyl)pyrrolidin-1-yl]methanone
  • [(2S,3aS,7aS)-2,3,3a,4,5,6,7,7a-octahydro-1H-indol-2-yl]-[(2S)-2-[oxo(2-thiazolyl)methyl]-1-pyrrolidinyl]methanone
  • [(2S,3aS,7aS)-2,3,3a,4,5,6,7,7a-octahydro-1H-indol-2-yl]-[(2S)-2-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-1-yl]methanone
  • [(2S,3aS,7aS)-2,3,3a,4,5,6,7,7a-octahydro-1H-indol-2-yl]-[(2S)-2-(thiazole-2-carbonyl)pyrrolidino]methanone
  • [(2S,3aS,7aS)-2,3,3a,4,5,6,7,7a-octahydro-1H-indol-2-yl]-[(2S)-2-[oxo-(2-thiazolyl)methyl]-1-pyrrolidinyl]methanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dipeptidyl-peptidase 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_128614 All targets in OG5_128614
Loa Loa (eye worm) prolyl oligopeptidase Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma japonicum ko:K01278 dipeptidyl-peptidase 4, putative Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus granulosus dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) Get druggable targets OG5_128614 All targets in OG5_128614
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog Get druggable targets OG5_128614 All targets in OG5_128614
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni intermediate filament proteins 0.0031 0.0763 0.0983
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0377 0.0486
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.2428 0.2428
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0377 0.0486
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0283 0.0365
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0279 0.0279
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.1667 0.885
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0054 0.1667 0.7031
Loa Loa (eye worm) hypothetical protein 0.0022 0.0377 0.0377
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0377 0.0377
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0377 0.0377
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0047 0.1381 0.5
Echinococcus granulosus jun protein 0.0095 0.3247 0.3247
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0526 0.0526
Echinococcus multilocularis acylamino acid releasing enzyme 0.0017 0.018 0.018
Schistosoma mansoni rab6-interacting 0.0019 0.0279 0.0359
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0377 0.0377
Echinococcus multilocularis jun protein 0.0095 0.3247 0.3247
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0377 0.0486
Loa Loa (eye worm) RNA binding protein 0.0074 0.2428 0.2428
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0526 0.0526
Schistosoma mansoni bromodomain containing protein 0.0071 0.233 0.3003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0644 0.0644
Echinococcus granulosus bloom syndrome protein 0.002 0.0307 0.0307
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0526 0.0678
Onchocerca volvulus 0.0031 0.0763 0.0983
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0307 0.0307
Trypanosoma brucei RNA helicase, putative 0.0177 0.6478 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0644 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0053 0.163 0.163
Echinococcus granulosus Dipeptidyl peptidase 9 0.007 0.2295 0.2295
Entamoeba histolytica DNA repair and recombination protein, putative 0.0054 0.1667 1
Schistosoma mansoni hypothetical protein 0.0077 0.255 0.3287
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0054 0.1667 0.2361
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0377 0.0486
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0307 0.0307
Schistosoma mansoni lamin 0.0031 0.0763 0.0983
Echinococcus multilocularis tar DNA binding protein 0.0074 0.2428 0.2428
Trypanosoma brucei unspecified product 0.0051 0.1539 0.2157
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0279 0.0279
Echinococcus multilocularis musashi 0.0031 0.0763 0.0763
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0763 0.0763
Loa Loa (eye worm) hypothetical protein 0.0022 0.0377 0.0377
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0307 0.0307
Toxoplasma gondii ribonuclease HI protein 0.0047 0.1381 0.5678
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0146 0.5291 0.5291
Trypanosoma brucei ISWI complex protein 0.0017 0.0206 0.004
Schistosoma mansoni hypothetical protein 0.0191 0.7032 0.9063
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.1861 0.7944
Schistosoma mansoni polycystin 1-related 0.0019 0.0279 0.0359
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0022 0.0377 0.0377
Onchocerca volvulus 0.0019 0.0279 0.0359
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0644 0.2193
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0377 0.0377
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0209 0.7759 0.7759
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.1861 0.1861
Echinococcus granulosus lamin 0.0031 0.0763 0.0763
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0377 0.0486
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0022 0.0377 0.0377
Echinococcus granulosus geminin 0.0191 0.7032 0.7032
Loa Loa (eye worm) prolyl oligopeptidase 0.0017 0.018 0.018
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0054 0.1667 0.2361
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0377 0.0486
Brugia malayi hypothetical protein 0.0028 0.0644 0.0644
Mycobacterium tuberculosis Probable peptidase 0.0017 0.018 0.5
Brugia malayi hypothetical protein 0.0074 0.2448 0.2448
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.1861 0.7944
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0377 0.0377
Echinococcus granulosus survival motor neuron protein 1 0.0266 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0283 0.0365
Loa Loa (eye worm) hypothetical protein 0.0022 0.0377 0.0377
Echinococcus multilocularis thyroid hormone receptor alpha 0.0168 0.614 0.614
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0377 0.0486
Loa Loa (eye worm) hypothetical protein 0.0168 0.6143 0.6143
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0377 0.0377
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0377 0.0377
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0283 0.0283
Brugia malayi PHD-finger family protein 0.0028 0.0631 0.0631
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0644 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.008 0.266 0.266
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0307 0.0752
Schistosoma mansoni lipoxygenase 0.0053 0.163 0.2101
Onchocerca volvulus 0.0031 0.0763 0.0983
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.1861 0.1861
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0377 0.0377
Schistosoma mansoni hypothetical protein 0.0177 0.6478 0.8348
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0377 0.0377
Echinococcus granulosus tar DNA binding protein 0.0074 0.2428 0.2428
Brugia malayi bZIP transcription factor family protein 0.0095 0.3247 0.3247
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.1861 0.1861
Leishmania major hypothetical protein, conserved 0.0028 0.0644 0.2193
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0189 0.0189
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.018 0.018
Echinococcus multilocularis ribonuclease H1 0.0047 0.1381 0.1381
Schistosoma mansoni zinc finger protein 0.0017 0.0206 0.0265
Echinococcus multilocularis muscleblind protein 0.0168 0.6143 0.6143
Loa Loa (eye worm) bromodomain containing protein 0.002 0.031 0.031
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0054 0.1667 0.1667
Schistosoma mansoni hypothetical protein 0.0023 0.0442 0.0569
Schistosoma mansoni tar DNA-binding protein 0.0074 0.2428 0.3129
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0283 0.0283
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0029 0.0029
Trypanosoma brucei ingi protein (ORF1) 0.0051 0.1539 0.2157
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0377 0.0377
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0307 0.0307
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.1861 0.7944
Echinococcus multilocularis survival motor neuron protein 1 0.0266 1 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0377 0.0377
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0051 0.1539 0.2157
Schistosoma mansoni hypothetical protein 0.0054 0.1667 0.2149
Onchocerca volvulus 0.0054 0.1664 0.2145
Echinococcus multilocularis bloom syndrome protein 0.002 0.0307 0.0307
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0377 0.0377
Giardia lamblia Ribonuclease H 0.0047 0.1381 0.7147
Echinococcus granulosus intermediate filament protein 0.0031 0.0763 0.0763
Echinococcus granulosus lamin dm0 0.0031 0.0763 0.0763
Schistosoma mansoni phosphoglucomutase 0.0047 0.1381 0.178
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0017 0.018 0.5
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0146 0.5291 0.5291
Brugia malayi TAR-binding protein 0.0074 0.2428 0.2428
Loa Loa (eye worm) hypothetical protein 0.0048 0.1417 0.1417
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0279 0.0279
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0377 0.0377
Brugia malayi Doublecortin family protein 0.0019 0.0279 0.0279
Trypanosoma cruzi ISWI complex protein 0.0017 0.0206 0.0119
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0307 0.2723
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0377 0.0486
Trypanosoma brucei protein kinase, putative 0.0059 0.1861 0.2668
Echinococcus multilocularis RUN 0.0019 0.0279 0.0279
Schistosoma mansoni lipoxygenase 0.0019 0.0279 0.0359
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0307 0.0307
Loa Loa (eye worm) RecQ helicase 0.002 0.0307 0.0307
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0644 0.2193
Brugia malayi hypothetical protein 0.0054 0.1643 0.1643
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.018 0.018
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0029 0.0029
Schistosoma mansoni jun-related protein 0.0077 0.255 0.3287
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0644 0.2193
Brugia malayi Bromodomain containing protein 0.0084 0.2849 0.2849
Entamoeba histolytica hypothetical protein, conserved 0.0054 0.1667 1
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0644 0.0737
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0377 0.0377
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0442 0.0442
Loa Loa (eye worm) hypothetical protein 0.0017 0.018 0.018
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0377 0.0377
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.018 0.0233
Onchocerca volvulus 0.0074 0.2448 0.3155
Echinococcus multilocularis geminin 0.0191 0.7032 0.7032
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0377 0.0486
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0307 0.0307
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0377 0.0377
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.007 0.2295 0.2958
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0209 0.7759 0.7759
Echinococcus granulosus RUN 0.0019 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0266 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0377 0.0377
Echinococcus granulosus ribonuclease H1 0.0047 0.1381 0.1381
Brugia malayi RNase H family protein 0.0047 0.1381 0.1381
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.007 0.2295 1
Schistosoma mansoni rab6-interacting 0.0019 0.0279 0.0359
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0377 0.0377
Schistosoma mansoni tar DNA-binding protein 0.0074 0.2428 0.3129
Brugia malayi hypothetical protein 0.0018 0.0249 0.0249
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0017 0.018 0.0233
Treponema pallidum ribonuclease H (rnhA) 0.0047 0.1381 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0095 0.3247 0.3247
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0377 0.0486
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.1119 0.1119
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.2172 0.2172
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0307 0.0752
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0283 0.0283
Schistosoma mansoni tar DNA-binding protein 0.0074 0.2428 0.3129
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.1861 0.2668
Trypanosoma cruzi ribonuclease H1, putative 0.0047 0.1381 0.5678
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.018 0.0233
Loa Loa (eye worm) hypothetical protein 0.0022 0.0377 0.0377
Brugia malayi MAP kinase sur-1 0.0059 0.1861 0.1861
Leishmania major hypothetical protein, conserved 0.0017 0.0206 0.0119
Brugia malayi ecdysteroid receptor 0.0022 0.0377 0.0377
Schistosoma mansoni hypothetical protein 0.0054 0.1664 0.2145
Loa Loa (eye worm) hypothetical protein 0.0046 0.1332 0.1332
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.1861 1
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.1861 0.2398
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.2428 0.2428
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0279 0.0279
Entamoeba histolytica recQ family helicase, putative 0.002 0.0307 0.0849
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0015 0.0124 0.0124
Schistosoma mansoni thyroid hormone receptor 0.0168 0.614 0.7913
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0763 0.0763
Brugia malayi RNase H family protein 0.0047 0.1381 0.1381
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.018 0.0233
Loa Loa (eye worm) hypothetical protein 0.0168 0.6143 0.6143
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0279 0.0279
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0124 0.0124
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.1861 0.7944
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0307 0.0597
Schistosoma mansoni survival motor neuron protein 0.0054 0.1664 0.2145
Schistosoma mansoni phosphoglucomutase 0.0047 0.1381 0.178
Schistosoma mansoni coup transcription factor 0.0022 0.0377 0.0486
Brugia malayi nuclear hormone receptor 0.0022 0.0377 0.0377
Echinococcus multilocularis muscleblind protein 1 0.0168 0.6143 0.6143
Loa Loa (eye worm) hypothetical protein 0.0017 0.018 0.018
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0017 0.018 0.5
Leishmania major ribonuclease H1, putative 0.0047 0.1381 0.5678
Schistosoma mansoni hypothetical protein 0.0017 0.0206 0.0265
Onchocerca volvulus 0.0019 0.0279 0.0359
Loa Loa (eye worm) hypothetical protein 0.0031 0.074 0.074
Schistosoma mansoni hypothetical protein 0.0191 0.7032 0.9063
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0307 0.0307
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.1861 1
Brugia malayi prolyl oligopeptidase family protein 0.007 0.2295 0.2295
Onchocerca volvulus Ribonuclease H1 homolog 0.0047 0.1381 0.178
Loa Loa (eye worm) hypothetical protein 0.0043 0.1227 0.1227
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0209 0.7759 1
Schistosoma mansoni hypothetical protein 0.0013 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.0017 0.018 0.018
Brugia malayi intermediate filament protein 0.0031 0.0763 0.0763
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0279 0.2119
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0307 0.0597
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.1861 0.7944
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0377 0.0377
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0377 0.0377
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0019 0.0279 0.0279
Echinococcus multilocularis prolyl endopeptidase 0.0017 0.018 0.018
Schistosoma mansoni loxhd1 0.0019 0.0279 0.0359
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0279 0.0279
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0377 0.0377
Brugia malayi RNase H family protein 0.0047 0.1381 0.1381
Schistosoma mansoni lamin 0.0031 0.0763 0.0983
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0377 0.0377
Schistosoma mansoni hypothetical protein 0.0019 0.0279 0.0359
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.1664 0.1664
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.007 0.2295 1
Onchocerca volvulus 0.0022 0.0377 0.0486
Schistosoma mansoni DNA helicase recq1 0.002 0.0307 0.0395
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0377 0.0377
Brugia malayi Bromodomain containing protein 0.0043 0.1224 0.1224
Echinococcus granulosus acylamino acid releasing enzyme 0.0017 0.018 0.018
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.4815 0.4815
Trichomonas vaginalis ribonuclease H1, putative 0.0047 0.1381 0.7147
Brugia malayi RNA binding protein 0.0074 0.2428 0.2428
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0053 0.163 0.163
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0377 0.0486
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0377 0.0377
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.1861 0.7944
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.018 0.018
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.1861 0.1861
Trypanosoma brucei ingi protein (ORF1) 0.0051 0.1539 0.2157
Brugia malayi hypothetical protein 0.0019 0.0279 0.0279
Giardia lamblia Rrm3p helicase 0.0054 0.1667 0.885
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0307 0.2723
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.1861 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0101 0.0101
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0054 0.1667 0.7031
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.007 0.2295 0.3359
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.1861 1
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0377 0.0377
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0377 0.0377
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0377 0.0377
Trypanosoma brucei ribonuclease H1 0.0047 0.1381 0.1907
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0763 0.0763
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0644 1
Echinococcus multilocularis lamin dm0 0.0031 0.0763 0.0763
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0377 0.0377
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0054 0.1643 0.1643
Brugia malayi MH2 domain containing protein 0.0134 0.4815 0.4815
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0054 0.1667 0.7031
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0377 0.0377
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0279 0.2119
Loa Loa (eye worm) hypothetical protein 0.0092 0.3145 0.3145
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0307 0.0307
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0377 0.0377
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0377 0.0377
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0054 0.1667 0.1667
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0377 0.0377
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.1861 0.1861
Schistosoma mansoni zinc finger protein 0.0022 0.0395 0.0509
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0017 0.018 0.5
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0209 0.7759 1
Brugia malayi steroid hormone receptor 0.0022 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0031 0.0763 0.0763
Trypanosoma brucei hypothetical protein, conserved 0.0051 0.1539 0.2157
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0095 0.3247 0.3247
Loa Loa (eye worm) hypothetical protein 0.002 0.0307 0.0307
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0022 0.0377 0.0377
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0307 0.0597
Loa Loa (eye worm) hypothetical protein 0.0019 0.0279 0.0279
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0279 0.0279
Trypanosoma cruzi ribonuclease H1, putative 0.0047 0.1381 0.5678
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0283 0.0365
Echinococcus multilocularis lamin 0.0031 0.0763 0.0763
Echinococcus granulosus muscleblind protein 0.0168 0.6143 0.6143
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.1861 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.1861 0.7944
Brugia malayi hypothetical protein 0.0019 0.0279 0.0279
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0283 0.0365
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0307 0.0597
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0307 0.0752
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0019 0.0283 0.0283
Schistosoma mansoni phosphoglucomutase 0.0047 0.1381 0.178
Schistosoma mansoni DNA helicase recq5 0.002 0.0307 0.0395
Echinococcus multilocularis Dipeptidyl peptidase 9 0.007 0.2295 0.2295
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0377 0.0377
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0054 0.1667 0.7031
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.4815 0.4815
Schistosoma mansoni tar DNA-binding protein 0.0074 0.2428 0.3129
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.2172 0.2172
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0377 0.0486
Schistosoma mansoni tar DNA-binding protein 0.0074 0.2428 0.3129
Loa Loa (eye worm) prolyl oligopeptidase 0.0209 0.7759 0.7759
Brugia malayi Muscleblind-like protein 0.0168 0.6143 0.6143
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0377 0.0377
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.1119 0.1119
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0377 0.0486
Echinococcus granulosus zinc finger protein 0.0022 0.0395 0.0395
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.007 0.2295 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0377 0.0377
Echinococcus granulosus prolyl endopeptidase 0.0017 0.018 0.018
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0307 0.0752
Schistosoma mansoni hypothetical protein 0.0146 0.5291 0.6819
Brugia malayi nuclear receptor NHR-88 0.0022 0.0377 0.0377
Echinococcus multilocularis zinc finger protein 0.0022 0.0395 0.0395
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.007 0.2295 1
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0054 0.1667 0.7031
Loa Loa (eye worm) hypothetical protein 0.0015 0.0101 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0377 0.0377
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.007 0.2295 0.3359
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0377 0.0377
Loa Loa (eye worm) TAR-binding protein 0.0074 0.2428 0.2428
Onchocerca volvulus Prolyl endopeptidase homolog 0.0017 0.018 0.0233
Trypanosoma cruzi ISWI complex protein 0.0017 0.0206 0.0119
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0307 0.0201
Schistosoma mansoni thyroid hormone receptor 0.0168 0.614 0.7913
Brugia malayi prolyl oligopeptidase family protein 0.0209 0.7759 0.7759

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 44 nM Inhibition of human recombinant DPP4 ChEMBL. 18053726
IC50 (binding) = 44 nM Inhibition of human recombinant DPP4 ChEMBL. 18053726

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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