Detailed information for compound 521270

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 474.552 | Formula: C27H30N4O4
  • H donors: 3 H acceptors: 4 LogP: 3.82 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)[C@H]1CN(C[C@H]1NC(=O)c1ccc(cc1)OCc1cc(C)nc2c1cccc2)CC(=C)C
  • InChi: 1S/C27H30N4O4/c1-17(2)13-31-14-23(27(33)30-34)25(15-31)29-26(32)19-8-10-21(11-9-19)35-16-20-12-18(3)28-24-7-5-4-6-22(20)24/h4-12,23,25,34H,1,13-16H2,2-3H3,(H,29,32)(H,30,33)/t23-,25+/m0/s1
  • InChiKey: JJARNQDLIPGYKD-UKILVPOCSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) Starlite/ChEMBL References
Sus scrofa ADAM17 Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 1 (interstitial collagenase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132656 All targets in OG5_132656
Echinococcus multilocularis adam 17 protease Get druggable targets OG5_132656 All targets in OG5_132656
Schistosoma mansoni ADAM17 peptidase (M12 family) Get druggable targets OG5_132656 All targets in OG5_132656
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin Get druggable targets OG5_132656 All targets in OG5_132656
Echinococcus granulosus adam 17 protease Get druggable targets OG5_132656 All targets in OG5_132656
Echinococcus granulosus Blood coagulation inhibitor Disintegrin Get druggable targets OG5_132656 All targets in OG5_132656
Schistosoma japonicum ko:K06059 a disintegrin and metalloproteinase domain 17, putative Get druggable targets OG5_132656 All targets in OG5_132656
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium yoelii A/G-specific adenine glycosylase, putative ADAM17   112 aa 109 aa 24.8 %
Onchocerca volvulus Putative glutaminase 3 ADAM17   112 aa 105 aa 45.7 %
Echinococcus granulosus disintegrin and metalloproteinase ADAM17   112 aa 99 aa 42.4 %
Brugia malayi Matrixin family protein matrix metallopeptidase 1 (interstitial collagenase) 403 aa 401 aa 27.7 %
Trypanosoma congolense hypothetical protein, conserved ADAM17   112 aa 100 aa 29.0 %
Echinococcus multilocularis disintegrin and metalloproteinase ADAM17   112 aa 99 aa 42.4 %
Onchocerca volvulus ADAM17   112 aa 98 aa 41.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0365 0.5959
Onchocerca volvulus 0.0037 0.0475 0.0765
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0377 0.0617
Leishmania major DNA polymerase kappa, putative 0.0023 0.021 0.1328
Plasmodium vivax hexose transporter 0.0104 0.1693 0.2158
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0191 0.0183
Onchocerca volvulus Matrix metalloproteinase homolog 0.0152 0.2575 0.4431
Trypanosoma brucei glucose transporter, putative 0.0032 0.0385 0.266
Loa Loa (eye worm) hypothetical protein 0.0031 0.0365 0.0395
Mycobacterium ulcerans hydrolase 0.0083 0.1322 1
Echinococcus multilocularis dnaJ subfamily B 0.0432 0.7704 0.7701
Brugia malayi jmjC domain containing protein 0.0093 0.1498 0.1723
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0555 0.3132
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0118 0.0109
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0341 0.0332
Toxoplasma gondii exonuclease III APE 0.002 0.016 0.019
Onchocerca volvulus Matrilysin homolog 0.0068 0.1049 0.1768
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0063 0.0039
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.046 0.3233
Leishmania major glucose transporter, lmgt3 0.0032 0.0385 0.266
Trypanosoma brucei sugar transporter, putative 0.0015 0.0063 0.0206
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.016 0.0146
Schistosoma mansoni hypothetical protein 0.0432 0.7704 0.7701
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.2376 0.2758
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0385 0.2104
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0334 0.227
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0316 0.0496
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0568 0.0559
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.044 0.3082
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0271 0.1794
Echinococcus multilocularis neuropeptide s receptor 0.045 0.8036 0.8034
Loa Loa (eye worm) hypothetical protein 0.0326 0.5766 0.6754
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.044 0.2437
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.2376 0.2369
Mycobacterium tuberculosis Probable dehydrogenase 0.0193 0.3332 0.8041
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0377 0.2603
Loa Loa (eye worm) hypothetical protein 0.0037 0.0475 0.0523
Leishmania major hypothetical protein, conserved 0.0015 0.0063 0.0206
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0555 0.3132
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.4129 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0377 0.0409
Plasmodium falciparum phd finger protein, putative 0.0028 0.0316 0.0403
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0168 0.0794
Brugia malayi Cytochrome P450 family protein 0.0049 0.069 0.0771
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0334 0.227
Onchocerca volvulus 0.0015 0.0063 0.0047
Loa Loa (eye worm) hypothetical protein 0.0037 0.0475 0.0523
Trypanosoma brucei unspecified product 0.0023 0.021 0.1328
Echinococcus granulosus dnaJ subfamily B 0.0432 0.7704 0.7701
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.016 0.1909
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0385 0.2104
Mycobacterium ulcerans hypothetical protein 0.0037 0.0475 0.3268
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0365 0.1988
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0029 0.0334 1
Brugia malayi Sugar transporter family protein 0.0104 0.1693 0.1953
Brugia malayi Cam kinase protein 1 0.0032 0.0377 0.0402
Echinococcus granulosus dna polymerase kappa 0.0023 0.021 0.0201
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0063 0.0054
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0365 0.0388
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0377 0.0481
Loa Loa (eye worm) hypothetical protein 0.0049 0.0687 0.0774
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.022 0.1402
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.057 0.3225
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0377 0.0481
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0475 0.0605
Echinococcus multilocularis dna polymerase kappa 0.0023 0.021 0.0201
Loa Loa (eye worm) hypothetical protein 0.0119 0.1979 0.2296
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0104 0.1693 0.1685
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.021 0.105
Echinococcus granulosus expressed conserved protein 0.0103 0.1679 0.1671
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0475 0.1012
Loa Loa (eye worm) sugar transporter 0.0104 0.1693 0.1958
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.016 0.0204
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0475 0.0466
Echinococcus granulosus GPCR family 2 0.0049 0.069 0.0681
Plasmodium falciparum thioredoxin reductase 0.0029 0.0334 0.0425
Leishmania major glucose transporter, lmgt2 0.0032 0.0385 0.266
Schistosoma mansoni protein kinase 0.0032 0.0377 0.0368
Onchocerca volvulus 0.0015 0.0063 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0385 0.2104
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Echinococcus granulosus General substrate transporter 0.0089 0.1426 0.1418
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.016 0.0151
Brugia malayi Hemopexin family protein 0.0097 0.1573 0.1811
Mycobacterium leprae Probable lipase LipE 0.0037 0.0475 0.0892
Brugia malayi hypothetical protein 0.0326 0.5766 0.6752
Echinococcus multilocularis geminin 0.0366 0.6497 0.6494
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0039
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.2696 0.314
Onchocerca volvulus 0.0097 0.1576 0.2688
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.044 0.2437
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.069 0.0681
Schistosoma mansoni ap endonuclease 0.002 0.016 0.0151
Mycobacterium tuberculosis Probable reductase 0.0193 0.3332 0.8041
Toxoplasma gondii thioredoxin reductase 0.0085 0.1346 0.252
Loa Loa (eye worm) hypothetical protein 0.0068 0.1049 0.12
Brugia malayi hypothetical protein 0.0026 0.0271 0.0277
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.057 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0475 0.1012
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.022 0.0211
Loa Loa (eye worm) glutathione reductase 0.0085 0.1346 0.155
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0475 0.0466
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.046 0.3233
Entamoeba histolytica hypothetical protein 0.0042 0.0568 0.3012
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.044 0.2437
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0334 0.1795
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0271 0.1794
Onchocerca volvulus 0.0015 0.0063 0.0047
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0118 0.0104
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.021 0.1328
Trypanosoma brucei unspecified product 0.0016 0.0082 0.0348
Schistosoma mansoni hypothetical protein 0.0042 0.0568 0.0559
Loa Loa (eye worm) hypothetical protein 0.0037 0.0475 0.0523
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0153 0.0895
Brugia malayi lysyl-tRNA synthetase 0.0023 0.022 0.0216
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.046 0.3233
Onchocerca volvulus 0.0015 0.0063 0.0047
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0475 0.3346
Trypanosoma brucei glucose transporter, putative 0.0032 0.0385 0.266
Schistosoma mansoni hypothetical protein 0.0045 0.0625 0.0617
Loa Loa (eye worm) hypothetical protein 0.0154 0.2619 0.3049
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0118 0.0109
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0365 0.1866
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0334 0.0325
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0475 0.0466
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.021 0.0201
Echinococcus multilocularis solute carrier family 22 0.0015 0.0063 0.0054
Entamoeba histolytica hypothetical protein 0.0042 0.0568 0.3012
Onchocerca volvulus 0.0092 0.1474 0.2509
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.016 0.0238
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.016 0.0153
Schistosoma mansoni ap endonuclease 0.002 0.016 0.0151
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.016 0.0204
Schistosoma mansoni hypothetical protein 0.0105 0.1726 0.1718
Echinococcus granulosus solute carrier family 22 0.0015 0.0063 0.0054
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.022 0.3088
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0519 0.051
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.057 0.4078
Brugia malayi Matrixin family protein 0.0068 0.1049 0.1194
Brugia malayi Matrixin family protein 0.0068 0.1049 0.1194
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0334 0.0531
Brugia malayi CHE-14 protein 0.0047 0.0656 0.0731
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0334 0.1795
Schistosoma mansoni hypothetical protein 0.0104 0.1693 0.1685
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.044 0.2288
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0063 0.0039
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.022 0.0211
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0334 0.0425
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.021 0.0205
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0334 0.2148
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0377 0.0402
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0118 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.021 0.1328
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0118 0.0108
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0193 0.3332 0.8041
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0385 0.266
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0341 0.0332
Schistosoma mansoni glucose transport protein 0.0104 0.1693 0.1685
Plasmodium vivax thioredoxin reductase, putative 0.0085 0.1346 0.1716
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0334 0.0351
Plasmodium falciparum thioredoxin reductase 0.0085 0.1346 0.1716
Plasmodium vivax glutathione reductase, putative 0.0085 0.1346 0.1716
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0334 0.227
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0385 0.266
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0153 0.0145
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0365 0.0356
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0153 0.0145
Schistosoma mansoni protein kinase 0.0032 0.0377 0.0368
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0352 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0063 0.0163
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.1693 0.1685
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.021 0.1328
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0063 0.0163
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0083 0.1322 0.1516
Onchocerca volvulus 0.0097 0.1573 0.2682
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.021 0.1328
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0118 0.0625
Loa Loa (eye worm) sugar transporter 0.0015 0.0063 0.0039
Entamoeba histolytica protein kinase, putative 0.0032 0.0377 0.1933
Onchocerca volvulus Huntingtin homolog 0.0119 0.1979 0.3392
Onchocerca volvulus Alhambra homolog 0.0028 0.0316 0.0488
Echinococcus granulosus peregrin 0.0032 0.0379 0.037
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0063 0.0032
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0039
Trypanosoma brucei unspecified product 0.0016 0.0082 0.0348
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.016 0.0702
Entamoeba histolytica hypothetical protein 0.0023 0.022 0.1041
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.021 0.1328
Brugia malayi Matrixin family protein 0.0068 0.1049 0.1194
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0334 0.227
Brugia malayi hypothetical protein 0.0015 0.0063 0.0032
Onchocerca volvulus 0.0015 0.0063 0.0047
Leishmania major hypothetical protein, conserved 0.0026 0.0271 0.1794
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0063 0.0206
Echinococcus multilocularis Niemann Pick C1 protein 0.0109 0.1801 0.1793
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0385 0.266
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0377 0.0481
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0047 0.0656 0.0738
Schistosoma mansoni glucose transport protein 0.0104 0.1693 0.1685
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.046 0.3233
Echinococcus granulosus survival motor neuron protein 1 0.0477 0.8522 0.8521
Echinococcus granulosus neuropeptide receptor A26 0.045 0.8036 0.8034
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0918 0.0909
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0118 0.015
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0365 0.0356
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.057 0.0562
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.044 0.2288
Brugia malayi Thioredoxin reductase 0.0085 0.1346 0.1544
Schistosoma mansoni cpg binding protein 0.003 0.0352 0.0343
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.022 0.0211
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0457 0.0448
Trypanosoma brucei glucose transporter, putative 0.0032 0.0385 0.266
Entamoeba histolytica hypothetical protein 0.0042 0.0568 0.3012
Brugia malayi Cytochrome P450 family protein 0.0019 0.0153 0.0138
Schistosoma mansoni cpg binding protein 0.0032 0.0383 0.0374
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.021 0.105
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0377 0.0481
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0918 0.0909
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0334 0.0425
Schistosoma mansoni cpg binding protein 0.0032 0.0383 0.0374
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0869 0.0988
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0249 0.4351 0.4346
Leishmania major hypothetical protein, conserved 0.0037 0.0475 0.3346
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0153 0.0717
Trypanosoma brucei glucose transporter, putative 0.0032 0.0385 0.266
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.021 0.1328
Echinococcus multilocularis General substrate transporter 0.0089 0.1426 0.1418
Treponema pallidum NADH oxidase 0.0029 0.0334 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0215 0.3727 0.9011
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0118 0.0135
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0039
Brugia malayi Calcitonin receptor-like protein seb-1 0.0154 0.2619 0.3044
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0385 0.2104
Brugia malayi hypothetical protein 0.0015 0.0063 0.0032
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0063 0.0054
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0156 0.0228
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0063 0.0054
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0377 0.0481
Brugia malayi hypothetical protein 0.0119 0.1979 0.229
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0063 0.0032
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0334 0.0425
Loa Loa (eye worm) hypothetical protein 0.0037 0.0475 0.0523
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.022 0.0308
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0475 0.1012
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.069 0.0778
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.021 0.1328
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.2227 0.2587
Trypanosoma brucei glucose transporter, putative 0.0032 0.0385 0.266
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0475 0.1012
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0156 0.0228
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0083 0.1322 0.3097
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0082 0.0348
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.057 0.4078
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.022 0.1109
Loa Loa (eye worm) matrixin family protein 0.0165 0.2825 0.3292
Loa Loa (eye worm) hypothetical protein 0.0477 0.8522 1
Onchocerca volvulus Huntingtin homolog 0.0119 0.1979 0.3392
Plasmodium vivax sugar transporter, putative 0.0015 0.0063 0.008
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Echinococcus multilocularis cpg binding protein 0.0032 0.0383 0.0374
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0475 0.2646
Schistosoma mansoni alpha glucosidase 0.0035 0.044 0.0431
Echinococcus granulosus geminin 0.0366 0.6497 0.6494
Echinococcus granulosus solute carrier family 22 0.0015 0.0063 0.0054
Schistosoma mansoni hypothetical protein 0.0049 0.069 0.0681
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.021 0.1328
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0492 0.2583
Echinococcus multilocularis dna polymerase eta 0.0023 0.021 0.0201
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0377 0.0368
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.057 0.4078
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0555 0.0966
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0334 0.227
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0918 0.0909
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.044 0.0483
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0039
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0334 0.0425
Loa Loa (eye worm) hypothetical protein 0.0068 0.1049 0.12
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0271 0.0346
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0377 0.2059
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0475 0.3346
Schistosoma mansoni hypothetical protein 0.0028 0.0316 0.0307
Toxoplasma gondii ABC1 family protein 0.0037 0.0475 0.0808
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0475 0.3346
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0377 0.0368
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0118 0.0108
Trypanosoma cruzi trypanothione reductase, putative 0.0085 0.1346 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0316 0.0307
Plasmodium vivax CDK-related protein kinase 6, putative 0.044 0.7846 1
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0519 0.051
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0334 0.2148
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0457 0.0448
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.022 0.0179
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0557 1 1
Echinococcus multilocularis GPCR, family 2 0.0049 0.069 0.0681
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0365 0.0356
Loa Loa (eye worm) hypothetical protein 0.0294 0.5182 0.6066
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0118 0.0109
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.057 0.3028
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0039
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.2376 0.2369
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0118 0.0626
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.069 0.0777
Loa Loa (eye worm) hypothetical protein 0.0026 0.0271 0.0284
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.057 0.0562
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0167 0.2861 0.5495
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.069 0.0681
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Echinococcus multilocularis protein patched 0.0047 0.0656 0.0648
Echinococcus granulosus Protein patched homolog 1 0.0047 0.0656 0.0648
Loa Loa (eye worm) matrix metalloproteinase 0.0068 0.1049 0.12
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0082 0.0348
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0377 0.0368
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0555 0.0966
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0425 0.0416
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0365 0.0356
Loa Loa (eye worm) hypothetical protein 0.0083 0.1322 0.1522
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0334 0.0531
Onchocerca volvulus 0.0015 0.0063 0.0047
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0475 0.2646
Echinococcus granulosus solute carrier family 22 0.0015 0.0063 0.0054
Schistosoma mansoni hypothetical protein 0.0049 0.069 0.0681
Loa Loa (eye worm) hypothetical protein 0.0058 0.085 0.0966
Trypanosoma brucei glucose transporter 2A 0.0032 0.0385 0.266
Onchocerca volvulus 0.0015 0.0063 0.0047
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.057 0.3225
Schistosoma mansoni glucose transporter 0.0015 0.0063 0.0054
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0118 0.0109
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0334 1
Plasmodium falciparum glutathione reductase 0.0029 0.0334 0.0425
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0334 0.227
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.1693 0.1685
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.057 0.063
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0063 0.0206
Onchocerca volvulus 0.0015 0.0063 0.0047
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0118 0.0109
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.1693 0.1685
Plasmodium falciparum proline--tRNA ligase 0.0036 0.046 0.0586
Trichomonas vaginalis ap endonuclease, putative 0.002 0.016 0.0748
Schistosoma mansoni hypothetical protein 0.0049 0.069 0.0681
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0918 0.0909
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0334 0.227
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0555 0.0546
Echinococcus multilocularis sterol regulatory element binding protein 0.0047 0.0656 0.0648
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.2304 0.2297
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.021 0.1168
Leishmania major trypanothione reductase 0.0085 0.1346 1
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0271 0.0409
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0334 0.227
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.022 0.028
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.016 0.0769
Schistosoma mansoni sugar transporter 0.0015 0.0063 0.0054
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0475 0.3268
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0918 0.6788
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.021 0.0362
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.057 0.0562
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.021 0.0201
Loa Loa (eye worm) hypothetical protein 0.0119 0.1979 0.2296
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0334 0.2148
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.016 0.0151
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0334 0.227
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.2227 0.2587
Plasmodium falciparum mitogen-activated protein kinase 2 0.0167 0.2861 0.3647
Loa Loa (eye worm) hypothetical protein 0.0028 0.0316 0.0337
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.2696 0.2689
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0167 0.2861 0.3647
Echinococcus multilocularis adam 17 protease 0.0557 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.045 0.8036 0.8034
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0568 0.0559
Echinococcus multilocularis peregrin 0.0032 0.0379 0.037
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0475 0.3268
Loa Loa (eye worm) hypothetical protein 0.0047 0.0656 0.0738
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0215 0.3727 1
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0385 0.2104
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0475 0.0517
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0063 0.0206
Schistosoma mansoni sugar transporter 0.0015 0.0063 0.0054
Mycobacterium leprae PROBABLE HYDROLASE 0.0083 0.1322 0.3266
Leishmania major glucose transporter, lmgt1 0.0032 0.0385 0.266
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.016 0.0946
Schistosoma mansoni DNA polymerase eta 0.0023 0.021 0.0201
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.01 0.1627 0.162
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.021 0.0205
Onchocerca volvulus Matrilysin homolog 0.0152 0.2575 0.4431
Schistosoma mansoni sugar transporter 0.0015 0.0063 0.0054
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0039
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0377 0.0481
Loa Loa (eye worm) hypothetical protein 0.0105 0.1726 0.1997
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0118 0.0626
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0294 0.5182 0.5177
Schistosoma mansoni alpha-glucosidase 0.0136 0.2292 0.2285
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0385 0.266
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0492 0.845
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0385 0.266
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0334 0.0325
Schistosoma mansoni jumonji domain containing protein 0.0074 0.1148 0.114
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0249 0.4351 0.4346
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.044 0.2437
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0334 1
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0263 0.4615 0.461
Loa Loa (eye worm) matrixin family protein 0.0152 0.2575 0.2997
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0118 0.015
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.1576 0.1815
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0316 0.0496
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0063 0.0163
Plasmodium falciparum hexose transporter 0.0104 0.1693 0.2158
Leishmania major cytochrome p450-like protein 0.0019 0.0153 0.0895
Toxoplasma gondii facilitative glucose transporter GT1 0.0104 0.1693 0.3201
Trypanosoma brucei glucose transporter, putative 0.0032 0.0385 0.266
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Onchocerca volvulus 0.0015 0.0063 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.021 0.1328
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0063 0.0054
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Leishmania major protein kinase, putative 0.0032 0.0377 0.2603
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.022 0.028
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0377 0.0368
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0193 0.3332 0.8041
Echinococcus granulosus neuropeptide s receptor 0.045 0.8036 0.8034
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0039
Trichomonas vaginalis esterase, putative 0.0037 0.0475 0.2646
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0063 0.0032
Echinococcus multilocularis solute carrier family 22 0.0015 0.0063 0.0054
Onchocerca volvulus 0.0037 0.0475 0.0765
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0334 0.227
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0063 0.0054
Schistosoma mansoni hypothetical protein 0.0049 0.069 0.0681
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0475 0.2646
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1498 0.149
Brugia malayi Matrixin family protein 0.0165 0.2825 0.3287
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0918 0.6788
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.044 0.074
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0153 0.0145
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.046 0.0586
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.044 0.0431
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0377 0.0368
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.2696 0.2689
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0294 0.5182 0.5177
Loa Loa (eye worm) hypothetical protein 0.0032 0.0377 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0063 0.0163
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0555 0.0707
Brugia malayi Niemann-Pick C1 protein precursor 0.0109 0.1801 0.2079
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0475 0.1012
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0918 0.6728
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0918 0.2102
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0377 0.0368
Brugia malayi PHD-finger family protein 0.0028 0.0316 0.033
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Mycobacterium ulcerans beta-lactamase 0.0037 0.0475 0.3268
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.2696 0.3135
Onchocerca volvulus 0.0015 0.0063 0.0047
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0475 0.0892
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0271 0.0346
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.069 0.077
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.021 0.0362
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.016 0.3582
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.022 0.0211
Brugia malayi beta-lactamase family protein 0.0037 0.0475 0.0517
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0039
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0039
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0492 0.0627
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0334 0.227
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.069 0.0681
Echinococcus multilocularis Niemann Pick C1 protein 0.0156 0.2661 0.2654
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0215 0.3727 0.9011
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0118 0.0626
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0085 0.1346 0.3157
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0377 0.0368
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Trypanosoma brucei trypanothione reductase 0.0085 0.1346 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.021 0.1328
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0316 0.0307
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.044 0.2437
Schistosoma mansoni alpha-glucosidase 0.0136 0.2292 0.2285
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1498 0.149
Loa Loa (eye worm) beta-lactamase 0.0037 0.0475 0.0523
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0656 0.3744
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0193 0.3332 0.8895
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0475 0.0523
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0377 0.0368
Loa Loa (eye worm) hypothetical protein 0.0031 0.0365 0.0395
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.044 0.2437
Schistosoma mansoni hypothetical protein 0.0366 0.6497 0.6494
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0111 0.1832 0.1824
Loa Loa (eye worm) hypothetical protein 0.0025 0.0259 0.0269
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0911 0.1666
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0118 0.0109
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0063 0.0163
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.057 0.0562
Loa Loa (eye worm) hypothetical protein 0.0023 0.022 0.0223
Giardia lamblia DINP protein human, muc B family 0.0023 0.021 0.2897
Loa Loa (eye worm) hypothetical protein 0.0037 0.0475 0.0523
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.1693 0.1685
Schistosoma mansoni hypothetical protein 0.0045 0.0625 0.0617
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.021 0.1328
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.057 0.4078
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.021 0.1328
Brugia malayi hypothetical protein 0.0017 0.0103 0.0079
Echinococcus multilocularis protein dispatched 1 0.0054 0.0778 0.0769
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0475 0.0466
Brugia malayi Matrixin family protein 0.0068 0.1049 0.1194
Trypanosoma brucei glucosidase, putative 0.0035 0.044 0.3082
Loa Loa (eye worm) acetyltransferase 0.0141 0.2376 0.2763
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0475 0.1012
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0568 0.0559
Schistosoma mansoni sugar transporter 0.0015 0.0063 0.0054
Onchocerca volvulus 0.0037 0.0475 0.0765
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0063 0.0163
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0334 0.227
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.044 0.2437
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.044 0.0431
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0104 0.0095
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.021 0.1328
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0377 0.0481
Onchocerca volvulus 0.0015 0.0063 0.0047
Echinococcus multilocularis expressed conserved protein 0.0103 0.1679 0.1671
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0334 0.227
Brugia malayi jmjC domain containing protein 0.0036 0.0457 0.0496
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.021 0.1328
Loa Loa (eye worm) hypothetical protein 0.0049 0.069 0.0777
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.021 0.1168
Brugia malayi CXXC zinc finger family protein 0.003 0.0352 0.0372
Onchocerca volvulus 0.0015 0.0063 0.0047
Brugia malayi hypothetical protein 0.0015 0.0063 0.0032
Trypanosoma brucei glucose transporter, putative 0.0032 0.0385 0.266
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Onchocerca volvulus 0.0015 0.0063 0.0047
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.022 0.1402
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0063 0.0206
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.044 0.3082
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.021 0.1328
Echinococcus multilocularis solute carrier family 22 0.0015 0.0063 0.0054
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.022 0.1244
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0063 0.008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.016 0.0946
Brugia malayi beta-lactamase 0.0037 0.0475 0.0517
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.069 0.0681
Schistosoma mansoni patched 1 0.0047 0.0656 0.0648
Brugia malayi Sugar transporter family protein 0.0015 0.0063 0.0032
Mycobacterium ulcerans lipase LipD 0.0037 0.0475 0.3268
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0334 0.227
Echinococcus granulosus dna polymerase eta 0.0023 0.021 0.0201
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0193 0.3332 0.8041
Trichomonas vaginalis ap endonuclease, putative 0.002 0.016 0.0748
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0334 0.5331
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0039
Brugia malayi hypothetical protein 0.0477 0.8522 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0475 0.2646
Brugia malayi major facilitator superfamily protein 0.0015 0.0063 0.0032
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0263 0.4615 0.461
Brugia malayi MH2 domain containing protein 0.0133 0.2227 0.2582
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.016 0.0946
Brugia malayi Latrophilin receptor protein 2 0.0049 0.069 0.077
Plasmodium falciparum protein kinase 7 0.0293 0.5155 0.657
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0118 0.0626
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.044 0.0476
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.021 0.1328
Onchocerca volvulus 0.0068 0.1049 0.1768
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0334 0.227
Plasmodium falciparum glutathione reductase 0.0085 0.1346 0.1716
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0153 0.0895
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0007
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0974 0.0966
Onchocerca volvulus 0.0015 0.0063 0.0047
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0316 0.0307
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.057 0.0562
Trypanosoma brucei glucose transporter 1E 0.0032 0.0385 0.266
Onchocerca volvulus 0.0326 0.5766 1
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0068 0.1049 0.1041
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.021 0.1328
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.057 0.3225
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0475 0.1012
Leishmania major DNA polymerase eta, putative 0.0023 0.021 0.1328
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0377 0.0617
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0082 0.0348
Schistosoma mansoni glucose transport protein 0.0104 0.1693 0.1685
Trypanosoma cruzi hexose transporter 0.0032 0.0385 0.266
Loa Loa (eye worm) thioredoxin reductase 0.0085 0.1346 0.155
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0377 0.0368
Echinococcus multilocularis thioredoxin glutathione reductase 0.0085 0.1356 0.1348
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.021 0.0986
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.046 0.3233
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0215 0.3727 0.9011
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.021 0.0201
Loa Loa (eye worm) hypothetical protein 0.0068 0.1049 0.12
Schistosoma mansoni hypothetical protein 0.0366 0.6497 0.6494
Mycobacterium tuberculosis Conserved protein 0.0037 0.0475 0.1012
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.022 0.1244
Giardia lamblia PHD finger protein 15 0.0028 0.0316 0.4982
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0063 0.0163
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Loa Loa (eye worm) hypothetical protein 0.0042 0.057 0.0636
Echinococcus granulosus cpg binding protein 0.0032 0.0383 0.0374
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0153 0.0895
Echinococcus granulosus solute carrier family 22 0.0015 0.0063 0.0054
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0109 0.1801 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0193 0.3332 0.8041
Brugia malayi Bromodomain containing protein 0.0032 0.0379 0.0404
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.044 0.2437
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.044 0.2437
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0918 0.1678
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0365 0.0587
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0385 0.266
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0136 0.0117
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0475 0.2646
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0154 0.2619 0.3044
Echinococcus multilocularis solute carrier family 22 0.0015 0.0063 0.0054
Loa Loa (eye worm) hypothetical protein 0.0109 0.1801 0.2085
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.1693 0.1685
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.044 0.3082
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.021 0.1328
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0385 0.266
Trypanosoma brucei glucose transporter, putative 0.0032 0.0385 0.266
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0365 0.0388
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.057 0.0562
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0918 0.6788
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0063 0.0163
Echinococcus multilocularis survival motor neuron protein 1 0.0477 0.8522 0.8521
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.057 0.0562
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.021 0.1328
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0385 0.2104
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0316 0.0403
Plasmodium falciparum protein kinase 6 0.044 0.7846 1
Schistosoma mansoni protein kinase 0.0032 0.0377 0.0368
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0039
Loa Loa (eye worm) hypothetical protein 0.0037 0.0475 0.0523
Entamoeba histolytica hypothetical protein 0.0042 0.0568 0.3012
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0039
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0271 0.1794
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0385 0.2104
Brugia malayi Cytochrome P450 family protein 0.0019 0.0153 0.0138
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.016 0.0946
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.021 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.1693 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0475 0.1012
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0039
Loa Loa (eye worm) hypothetical protein 0.0023 0.021 0.0212
Brugia malayi hypothetical protein 0.0042 0.0568 0.0626
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.057 0.0562
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0263 0.4615 0.5395
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0271 0.0346
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Echinococcus granulosus Niemann Pick C1 protein 0.0156 0.2661 0.2654
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0377 0.0617
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0457 0.0503
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0377 0.0409
Schistosoma mansoni survival motor neuron protein 0.0097 0.1576 0.1568
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0039
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.1693 0.1685
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.022 0.1402
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0334 0.227
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0334 0.227
Brugia malayi glutathione reductase 0.0085 0.1346 0.1544
Schistosoma mansoni hypothetical protein 0.0045 0.0625 0.0617
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0191 0.0183
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0334 0.0325
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.2696 0.2689
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.046 0.0779
Onchocerca volvulus Putative transporter 0.0015 0.0063 0.0047
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.021 0.0212
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0457 0.0448
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0063 0.0163
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0154 0.2619 0.3049
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0377 0.0481
Schistosoma mansoni hypothetical protein 0.0097 0.1576 0.1568
Schistosoma mansoni hypothetical protein 0.0045 0.0625 0.0617
Brugia malayi Sugar transporter family protein 0.0015 0.0063 0.0032
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0377 0.0481
Entamoeba histolytica protein kinase, putative 0.0032 0.0377 0.1933
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0316 0.0337
Onchocerca volvulus 0.0015 0.0063 0.0047
Brugia malayi beta-lactamase family protein 0.0037 0.0475 0.0517
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0334 0.0665
Echinococcus granulosus Niemann Pick C1 protein 0.0109 0.1801 0.1793
Echinococcus granulosus sterol regulatory element binding protein 0.0047 0.0656 0.0648
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.1693 0.1685
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0475 0.1012
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0118 0.0109
Toxoplasma gondii protein kinase, putative 0.0293 0.5155 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0085 0.1356 0.1348
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0263 0.4615 0.461
Onchocerca volvulus 0.0015 0.0063 0.0047
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0063 0.0206
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.021 0.1328
Brugia malayi isocitrate dehydrogenase 0.0018 0.0118 0.0097
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.1726 0.1991
Schistosoma mansoni hypothetical protein 0.0097 0.1573 0.1565
Onchocerca volvulus 0.003 0.0352 0.0551
Brugia malayi major facilitator superfamily protein 0.0015 0.0063 0.0032
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0118 0.0626

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.5 nM Inhibition of pig TACE ChEMBL. 18061445
IC50 (binding) = 1.5 nM Inhibition of pig TACE ChEMBL. 18061445
IC50 (functional) = 210 nM Inhibition of LPS-stimulated TNFalpha release in human whole blood ChEMBL. 18061445
IC50 (functional) = 210 nM Inhibition of LPS-stimulated TNFalpha release in human whole blood ChEMBL. 18061445
Ki (binding) > 2128 nM Binding affinity to MMP9 (unknown origin) ChEMBL. 18061445
Ki (binding) > 2128 nM Binding affinity to MMP9 (unknown origin) ChEMBL. 18061445
Ki (binding) > 3333 nM Binding affinity to MMP2 (unknown origin) ChEMBL. 18061445
Ki (binding) > 3333 nM Binding affinity to MMP2 (unknown origin) ChEMBL. 18061445
Ki (binding) > 4948 nM Binding affinity to MMP1 (unknown origin) ChEMBL. 18061445
Ki (binding) > 4948 nM Binding affinity to MMP1 (unknown origin) ChEMBL. 18061445
Papp (ADMET) = 9.8 10^-6 cm/s Apparent permeability from apical to basolateral side of human Caco2 cell membrane ChEMBL. 18061445
Papp (ADMET) = 9.8 10^-6 cm/s Apparent permeability from apical to basolateral side of human Caco2 cell membrane ChEMBL. 18061445

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 18061445

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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