Detailed information for compound 543674

Basic information

Technical information
  • TDR Targets ID: 543674
  • Name: 1-methyl-4H-pyridine-3-carboxylic acid
  • MW: 139.152 | Formula: C7H9NO2
  • H donors: 1 H acceptors: 2 LogP: 0.59 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1C=C(CC=C1)C(=O)O
  • InChi: 1S/C7H9NO2/c1-8-4-2-3-6(5-8)7(9)10/h2,4-5H,3H2,1H3,(H,9,10)
  • InChiKey: BCFPLUJRJLEPGV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,4-dihydrotrigonelline
  • 140201-08-7
  • 3-Pyridinecarboxylic acid, 1,4-dihydro-1-methyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Brugia malayi Pre-SET motif family protein 0.0205 0.4446 0.707
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0539 0.7084
Brugia malayi hypothetical protein 0.0026 0.0327 0.0471
Onchocerca volvulus 0.0015 0.0066 0.0065
Echinococcus multilocularis solute carrier family 22 0.0015 0.0066 0.0063
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0534 0.0948
Loa Loa (eye worm) hypothetical protein 0.0013 0.0033 0.0015
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0096 0.1931 0.3594
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.3643 0.6839
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0467 0.0745
Loa Loa (eye worm) MH2 domain-containing protein 0.024 0.5263 0.838
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0573 0.1022
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0477 0.084
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0188 0.2172
Trypanosoma brucei sugar transporter, putative 0.0015 0.0066 0.0463
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0534 0.0948
Brugia malayi hypothetical protein 0.0015 0.0066 0.0053
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0595 0.1064
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0103 0.0132
Treponema pallidum NADH oxidase 0.0015 0.0061 1
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0066 0.0106
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0468 0.0409
Mycobacterium tuberculosis Conserved protein 0.0035 0.0534 0.0948
Onchocerca volvulus 0.0015 0.0066 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0045 0.0161
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0066 0.0053
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0066 0.0063
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.005 0.0079
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Loa Loa (eye worm) hypothetical protein 0.0026 0.0327 0.0485
Echinococcus multilocularis GPCR, family 2 0.0015 0.0079 0.0085
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0266 0.3265
Toxoplasma gondii protein kinase, putative 0.0296 0.6565 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0061 0.0044
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0061 0.0386
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.2235 0.4171
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0538 0.0857
Brugia malayi MH1 domain containing protein 0.0016 0.0103 0.0112
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0477 0.6215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0277 0.0442
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0068
Toxoplasma gondii sugar transporter ST3 0.0015 0.0066 0.0051
Toxoplasma gondii sugar transporter ST1 0.0015 0.0066 0.0051
Echinococcus granulosus GPCR family 2 0.0015 0.0079 0.0085
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0066 0.0068
Loa Loa (eye worm) hypothetical protein 0.0033 0.0488 0.0741
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0467 0.0709
Mycobacterium ulcerans aldehyde dehydrogenase 0.0242 0.5312 0.8457
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0573 0.7558
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0277 0.0442
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0764 0.117
Brugia malayi hypothetical protein 0.0109 0.2235 0.3528
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0066 0.0106
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0066 0.0063
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0066 0.0063
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0188 0.2172
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0747 0.1352
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0452 0.0671
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0061 0.0386
Trypanosoma brucei glucose transporter, putative 0.0033 0.0477 0.6215
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0061 0.0386
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0015 0.0061 0.0044
Schistosoma mansoni alpha-glucosidase 0.0146 0.3098 0.491
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0595 0.0949
Loa Loa (eye worm) hypothetical protein 0.0031 0.0452 0.0685
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0015 0.0061 0.0052
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0595 0.09
Echinococcus granulosus dna polymerase kappa 0.002 0.0188 0.0294
Loa Loa (eye worm) hypothetical protein 0.0026 0.0316 0.0467
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0066 0.0106
Giardia lamblia GTOR 0.0044 0.0747 1
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0066 0.0053
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0188 0.2172
Trypanosoma brucei unspecified product 0.0014 0.0045 0.0161
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0068 0.0071
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0468 0.0409
Mycobacterium tuberculosis Conserved protein 0.0035 0.0534 0.0948
Toxoplasma gondii aldehyde dehydrogenase 0.0242 0.5312 0.8081
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0188 0.0294
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0188 0.0704
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2147 0.4004
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0068
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.005 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0538 0.0857
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.017 0.3643 0.579
Schistosoma mansoni hypothetical protein 0.0033 0.0488 0.0728
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0488 0.0728
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0013 0.0033 0.0015
Onchocerca volvulus 0.0015 0.0066 0.0065
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0061 0.8346
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0327 0.0268
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0188 0.2172
Schistosoma mansoni glucose transport protein 0.0105 0.2147 0.3386
Echinococcus multilocularis dna polymerase kappa 0.002 0.0188 0.0294
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0477 0.076
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0747 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.084 0.1292
Echinococcus granulosus solute carrier family 22 0.0015 0.0066 0.0063
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0403 0.0592
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0403 0.07
Mycobacterium leprae Probable lipase LipE 0.0035 0.0534 0.2334
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0061 0.0386
Trypanosoma brucei glucose transporter, putative 0.0033 0.0477 0.6215
Trichomonas vaginalis glutaminase, putative 0.0284 0.6275 1
Brugia malayi hypothetical protein 0.0015 0.0066 0.0053
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0188 0.0263
Onchocerca volvulus 0.0035 0.0534 0.0988
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0079 0.0087
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0534 0.0801
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0188 0.0294
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0266 0.1087
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0188 0.2172
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0595 0.0949
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.3643 0.6839
Brugia malayi beta-lactamase 0.0035 0.0534 0.0801
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0747 0.119
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.4446 0.7075
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0452 0.5871
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0477 0.076
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0764 0.1383
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0015 0.0061 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0188 0.2172
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0764 0.1383
Loa Loa (eye worm) glutathione reductase 0.0042 0.0693 0.1069
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0061 0.0097
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0068
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0061 0.0386
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.005 0.0079
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0534 0.085
Echinococcus multilocularis solute carrier family 22 0.0015 0.0066 0.0063
Brugia malayi Cytochrome P450 family protein 0.0018 0.0131 0.0156
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0061 0.0386
Loa Loa (eye worm) Smad1 0.0016 0.0103 0.0127
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0595 0.2552
Schistosoma mansoni smad1 5 8 and 0.0016 0.0103 0.0112
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0764 0.117
Plasmodium falciparum glutathione reductase 0.0042 0.0693 0.0635
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0421 0.0735
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0188 0.2172
Brugia malayi major facilitator superfamily protein 0.0015 0.0066 0.0053
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0266 0.0441
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0188 0.2172
Schistosoma mansoni hypothetical protein 0.0015 0.0079 0.0072
Brugia malayi beta-lactamase family protein 0.0035 0.0534 0.0801
Brugia malayi Thioredoxin reductase 0.0042 0.0693 0.1056
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0266 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0033 0.0015
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0452 0.0671
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0061 0.0386
Schistosoma mansoni glucose transport protein 0.0105 0.2147 0.3386
Schistosoma mansoni hypothetical protein 0.0105 0.2147 0.3386
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0045 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0411 0.0655
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0468 0.0409
Loa Loa (eye worm) hypothetical protein 0.0023 0.0266 0.0387
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0468 0.0409
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0534 0.085
Schistosoma mansoni alpha-glucosidase 0.0146 0.3098 0.491
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0534 0.0948
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0277 0.0442
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2147 0.4004
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0079 0.0085
Entamoeba histolytica hypothetical protein 0.0109 0.2235 1
Plasmodium falciparum protein kinase 7 0.0296 0.6565 0.6544
Loa Loa (eye worm) glutaminase 0.0284 0.6275 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0106 0.2177 0.406
Loa Loa (eye worm) aldehyde dehydrogenase 0.0013 0.0033 0.0015
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0068
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.0693 0.9238
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0015 0.0061 0.0044
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2147 0.4004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0336 0.0536
Onchocerca volvulus 0.0015 0.0066 0.0065
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0066 0.0463
Leishmania major glycosyl hydrolase-like protein 0.0014 0.005 0.0031
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0595 0.0949
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0066 0.0063
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0103 0.0127
Schistosoma mansoni hypothetical protein 0.0015 0.0079 0.0072
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0061 0.0386
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0595 0.2552
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0534 0.085
Onchocerca volvulus 0.0098 0.1992 0.3866
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0485 0.0692
Echinococcus granulosus Smad4 0.0016 0.0103 0.0132
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0534 0.0801
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0096 0.1931 0.3594
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0131 0.017
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0066 0.0068
Trypanosoma brucei glucose transporter, putative 0.0033 0.0477 0.6215
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0061 0.0052
Mycobacterium tuberculosis Probable dehydrogenase 0.0096 0.1931 0.3594
Onchocerca volvulus 0.0015 0.0066 0.0065
Loa Loa (eye worm) hypothetical protein 0.0035 0.0534 0.0815
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0485 0.0773
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0477 0.076
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0068 0.0066
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0013 0.0033 0.0053
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0061 0.0386
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0266 0.3265
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.005 0.0032
Entamoeba histolytica hypothetical protein 0.0023 0.0266 0.1058
Mycobacterium ulcerans glutaminase 0.0284 0.6275 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.005 0.0079
Entamoeba histolytica hypothetical protein 0.0109 0.2235 1
Onchocerca volvulus 0.0015 0.0066 0.0065
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0403 0.07
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0068
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0421 0.0735
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0327 0.045
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0534 0.0948
Mycobacterium tuberculosis Probable oxidoreductase 0.0106 0.2177 0.406
Plasmodium vivax thioredoxin reductase, putative 0.0042 0.0693 0.0635
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0336 0.0536
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0485 0.0773
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0103 0.0132
Entamoeba histolytica protein kinase, putative 0.0032 0.0467 0.1971
Mycobacterium tuberculosis Conserved protein 0.0035 0.0534 0.0948
Brugia malayi Glycosyl hydrolases family 31 protein 0.017 0.3643 0.5784
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0485 0.0773
Brugia malayi MH2 domain containing protein 0.0016 0.0103 0.0112
Trypanosoma brucei glucosidase, putative 0.0038 0.0595 0.7876
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0266 0.0373
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0096 0.1931 0.3594
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0327 0.412
Trichomonas vaginalis set domain proteins, putative 0.0233 0.5099 0.8125
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0266 0.0373
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0066 0.0106
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0764 0.1183
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0747 0.1156
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0188 0.2172
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.005 0.0079
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0747 0.1352
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0045 0.0161
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2147 0.4004
Echinococcus granulosus lysosomal alpha glucosidase 0.017 0.3643 0.6839
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0061 0.0052
Loa Loa (eye worm) thioredoxin reductase 0.0042 0.0693 0.1069
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0103 0.0112
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0394 0.0592
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0066 0.0005
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0595 0.0949
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0403 0.0592
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0066 0.0053
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0595 0.0914
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0277 0.0442
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0169 0.3638 0.3599
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0066 0.0106
Entamoeba histolytica hypothetical protein 0.0109 0.2235 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0534 0.0948
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.033 0.0526
Brugia malayi Cam kinase protein 1 0.0032 0.0467 0.0695
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0477 0.076
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0042 0.0693 0.1249
Mycobacterium tuberculosis Probable reductase 0.0096 0.1931 0.3594
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0079 0.0072
Trypanosoma brucei glucose transporter, putative 0.0033 0.0477 0.6215
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.084 0.1292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0276 0.0441
Brugia malayi beta-lactamase family protein 0.0035 0.0534 0.0801
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0534 0.2334
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0468 0.0409
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.005 0.0079
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0188 0.03
Onchocerca volvulus 0.0233 0.5099 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0105 0.2147 0.3235
Plasmodium vivax hexose transporter 0.0105 0.2147 0.2099
Brugia malayi major facilitator superfamily protein 0.0015 0.0066 0.0053
Loa Loa (eye worm) hypothetical protein 0.0035 0.0534 0.0815
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0485 0.0773
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0066 0.0463
Schistosoma mansoni protein kinase 0.0032 0.0467 0.0695
Loa Loa (eye worm) hypothetical protein 0.0032 0.0467 0.0709
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0534 0.085
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0061 0.0042
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.005 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0068 0.0109
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0068 0.0066
Leishmania major protein kinase, putative 0.0032 0.0467 0.0822
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0105 0.2147 0.4004
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.005 0.0026
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0079 0.0085
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0061 0.0052
Leishmania major DNA polymerase eta, putative 0.002 0.0188 0.0294
Loa Loa (eye worm) hypothetical protein 0.0029 0.0403 0.0606
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0061 0.0052
Echinococcus multilocularis smad 0.0016 0.0103 0.0132
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0079 0.0085
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0378 0.0653
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0477 0.6215
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0467 0.0695
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0068
Trypanosoma brucei cytochrome P450, putative 0.0018 0.0131 0.1364
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0068 0.049
Trichomonas vaginalis esterase, putative 0.0035 0.0534 0.085
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0068 0.0066
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0452 0.0671
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0068 0.0056
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0747 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0061 0.0386
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0066 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0538 0.0857
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0242 0.5312 1
Toxoplasma gondii sugar transporter ST2 0.0015 0.0066 0.0051
Loa Loa (eye worm) hypothetical protein 0.0048 0.084 0.1305
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Loa Loa (eye worm) beta-lactamase 0.0035 0.0534 0.0815
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0188 0.0248
Brugia malayi Pre-SET motif family protein 0.0029 0.0403 0.0592
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0327 0.0268
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0573 0.7558
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0467 0.0709
Plasmodium falciparum hexose transporter 0.0105 0.2147 0.2099
Onchocerca volvulus 0.0035 0.0534 0.0988
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0467 0.6081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0538 0.0857
Onchocerca volvulus 0.0015 0.0066 0.0065
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0068
Trypanosoma brucei glucose transporter, putative 0.0033 0.0477 0.6215
Echinococcus multilocularis solute carrier family 22 0.0015 0.0066 0.0063
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0468 0.0409
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0747 0.119
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0534 0.7011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0242 0.5312 0.8457
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0747 0.1143
Onchocerca volvulus 0.0029 0.0403 0.073
Brugia malayi glutaminase DH11.1 0.0284 0.6275 1
Mycobacterium ulcerans hypothetical protein 0.0035 0.0534 0.0801
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0188 0.0248
Loa Loa (eye worm) hypothetical protein 0.0035 0.0534 0.0815
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0188 0.2172
Echinococcus granulosus dna polymerase eta 0.002 0.0188 0.0294
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0066 0.0063
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0185 0.0287
Brugia malayi Cytochrome P450 family protein 0.0029 0.0394 0.0578
Leishmania major hypothetical protein, conserved 0.0015 0.0066 0.0063
Schistosoma mansoni alpha glucosidase 0.0038 0.0595 0.09
Loa Loa (eye worm) hypothetical protein 0.0035 0.0534 0.0815
Giardia lamblia DINP protein human, muc B family 0.002 0.0188 0.2172
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0403 0.0592
Echinococcus granulosus solute carrier family 22 0.0015 0.0066 0.0063
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0188 0.2172
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0066 0.0053
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0096 0.1931 0.8852
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0266 0.0425
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0061 0.8346
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0764 0.1383
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0266 0.3265
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0266 0.0207
Giardia lamblia NADH oxidase lateral transfer candidate 0.0015 0.0061 0.0386
Loa Loa (eye worm) sugar transporter 0.0015 0.0066 0.0068
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0079 0.0072
Onchocerca volvulus 0.0015 0.0066 0.0065
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0066 0.0053
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0595 0.1064
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0468 0.0665
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0066 0.0053
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0468 0.0665
Schistosoma mansoni Smad4 0.0016 0.0103 0.0112
Echinococcus granulosus General substrate transporter 0.009 0.1806 0.3359
Loa Loa (eye worm) hypothetical protein 0.0014 0.005 0.0041
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0068 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0188 0.2172
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0066 0.0106
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0266 0.0373
Loa Loa (eye worm) glutaminase 2 0.0284 0.6275 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0106 0.2177 1
Leishmania major glucose transporter, lmgt1 0.0033 0.0477 0.084
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0061 0.0052
Schistosoma mansoni protein kinase 0.0032 0.0467 0.0695
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0068 0.049
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0068
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0595 0.1064
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0534 0.0948
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0068 0.049
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0096 0.1931 0.3594
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0188 0.0248
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0061 0.0097
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0068
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.02 0.0318
Plasmodium falciparum mitogen-activated protein kinase 2 0.0169 0.3638 0.3599
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0468 0.0665
Mycobacterium ulcerans lipase LipD 0.0035 0.0534 0.0801
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0188 0.2172
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0103 0.0132
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0534 0.0801
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2147 0.4004
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.2235 0.3528
Echinococcus granulosus thioredoxin glutathione reductase 0.0042 0.0705 0.1273
Echinococcus multilocularis Smad4 0.0016 0.0103 0.0132
Onchocerca volvulus 0.0015 0.0066 0.0065
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0066 0.0063
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0595 0.0949
Echinococcus granulosus solute carrier family 22 0.0015 0.0066 0.0063
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0477 0.6215
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0266 0.0441
Giardia lamblia Sugar-proton symporter 0.0015 0.0066 0.0463
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0477 0.076
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0468 0.0409
Brugia malayi Sugar transporter family protein 0.0015 0.0066 0.0053
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0266 0.0357
Loa Loa (eye worm) hypothetical protein 0.0035 0.0534 0.0815
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.4886 0.9192
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Toxoplasma gondii ABC1 family protein 0.0035 0.0534 0.0766
Plasmodium vivax CDK-related protein kinase 6, putative 0.0445 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0079 0.0087
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0188 0.0248
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0131 0.1364
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0477 0.076
Schistosoma mansoni aldehyde dehydrogenase 0.0242 0.5312 0.8457
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0452 0.1902
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0066 1
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0477 0.6215
Onchocerca volvulus 0.0015 0.0066 0.0065
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0061 0.0044
Mycobacterium ulcerans aldehyde dehydrogenase 0.0242 0.5312 0.8457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0336 0.0536
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0534 0.0948
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0467 0.0822
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0266 0.0373
Echinococcus multilocularis General substrate transporter 0.009 0.1806 0.3359
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0013 0.0033 0.0015
Onchocerca volvulus 0.0015 0.0066 0.0065
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0595 0.7876
Schistosoma mansoni sugar transporter 0.0015 0.0066 0.0053
Schistosoma mansoni smad1 5 8 and 0.0016 0.0103 0.0112
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0327 0.412
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0534 0.0948
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0209 0.2458
Leishmania major glucose transporter, lmgt3 0.0033 0.0477 0.084
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0477 0.076
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0103 0.0127
Brugia malayi MH2 domain containing protein 0.0016 0.0103 0.0112
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Brugia malayi hypothetical protein 0.0017 0.0114 0.013
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0188 0.2172
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0477 0.6215
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.005 0.023
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.005 0.023
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0468 0.0409
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0534 0.0948
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0534 0.7011
Schistosoma mansoni sugar transporter 0.0015 0.0066 0.0053
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0534 0.0801
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0452 0.1954
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0764 0.117
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.005 0.0079
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0747 0.1143
Trypanosoma brucei glucose transporter 2A 0.0033 0.0477 0.6215
Trypanosoma brucei glucose transporter 1E 0.0033 0.0477 0.6215
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0068
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0539 0.7084
Loa Loa (eye worm) sugar transporter 0.0105 0.2147 0.3396
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.005 0.023
Mycobacterium ulcerans sugar transporter 0.0015 0.0066 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0188 0.2172
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0595 0.0949
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0485 0.0773
Leishmania major hypothetical protein, conserved 0.0026 0.0327 0.0557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0538 0.0857
Echinococcus granulosus solute carrier family 22 0.0015 0.0066 0.0063
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0188 0.0248
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0573 0.0515
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0534 0.7011
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0106 0.2177 0.406
Giardia lamblia Hexose transporter 0.0015 0.0066 0.0463
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0539 0.0957
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0266 0.0373
Schistosoma mansoni sugar transporter 0.0015 0.0066 0.0053
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0403 0.07
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0403 0.0592
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.2235 0.4171
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2147 0.4004
Schistosoma mansoni glutaminase 0.0284 0.6275 1
Loa Loa (eye worm) transcription factor SMAD2 0.024 0.5263 0.838
Loa Loa (eye worm) hypothetical protein 0.0035 0.0534 0.0815
Schistosoma mansoni smad1 5 8 and 0.0016 0.0103 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0276 0.0441
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0079 0.0085
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0467 0.0822
Leishmania major DNA polymerase kappa, putative 0.002 0.0188 0.0294
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0242 0.5312 1
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0266 0.0441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0068 0.0109
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0467 0.0822
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0068 0.0109
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0534 0.0476
Brugia malayi Smad1 0.0016 0.0103 0.0112
Onchocerca volvulus 0.0015 0.0066 0.0065
Trypanosoma brucei glucose transporter, putative 0.0033 0.0477 0.6215
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0467 0.0822
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Brugia malayi Sugar transporter family protein 0.0015 0.0066 0.0053
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0169 0.3638 0.5518
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0188 0.03
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0595 0.7876
Schistosoma mansoni aldehyde dehydrogenase 0.0242 0.5312 0.8457
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0185 0.0287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0747 0.119
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0066 0.0463
Echinococcus multilocularis dna polymerase eta 0.002 0.0188 0.0294
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2147 0.4004
Echinococcus multilocularis solute carrier family 22 0.0015 0.0066 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0188 0.2172
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0468 0.0409
Trypanosoma brucei unspecified product 0.002 0.0188 0.2172
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0242 0.5312 1
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.2147 0.3421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.033 0.0526
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0061 0.0386
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0573 0.0515
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0136 0.1444
Loa Loa (eye worm) hypothetical protein 0.0031 0.0452 0.0685
Leishmania major trypanothione reductase 0.0042 0.0693 0.1249
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0485 0.0773
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0534 0.0815
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0131 0.1364
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0467 0.0822
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0068
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0066 0.0463
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0747 0.324
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0467 0.0822
Brugia malayi MH2 domain containing protein 0.024 0.5263 0.8378
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0452 0.0721
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0242 0.5312 1
Toxoplasma gondii thioredoxin reductase 0.0042 0.0693 0.1009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0068 0.0109
Brugia malayi glutathione reductase 0.0042 0.0693 0.1056
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0068
Loa Loa (eye worm) hypothetical protein 0.002 0.0188 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0276 0.0441
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0188 0.0294
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0452 0.0794
Trypanosoma brucei glucose transporter, putative 0.0033 0.0477 0.6215
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0266 0.0207
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0534 0.0801
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0061 0.0042
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0188 0.0294
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0068
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0188 0.2172
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0764 0.117
Leishmania major cytochrome p450-like protein 0.0018 0.0131 0.0184
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0188 0.2172
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0061 0.0052
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0061 0.0386
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0747 0.324
Schistosoma mansoni glucose transporter 0.0015 0.0066 0.0053
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.005 0.0074
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0061 0.0386
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0747 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.084 0.1305
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0188 0.0248
Schistosoma mansoni hypothetical protein 0.0015 0.0079 0.0072
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0452 0.0794
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0467 0.0695
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Onchocerca volvulus Putative transporter 0.0015 0.0066 0.0065
Leishmania major glucose transporter, lmgt2 0.0033 0.0477 0.084
Entamoeba histolytica protein kinase, putative 0.0032 0.0467 0.1971
Trypanosoma brucei trypanothione reductase 0.0042 0.0693 0.9238
Mycobacterium ulcerans beta-lactamase 0.0035 0.0534 0.0801
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0185 0.0707
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0066 0.0106
Echinococcus granulosus smad 0.0016 0.0103 0.0132
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0068
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0467 0.0822
Leishmania major hypothetical protein, conserved 0.0035 0.0534 0.0948
Schistosoma mansoni glucose transport protein 0.0105 0.2147 0.3386
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0477 0.6215
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0573 0.7558
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0595 0.0949
Schistosoma mansoni hypothetical protein 0.0015 0.0079 0.0072
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Schistosoma mansoni hypothetical protein 0.0109 0.2235 0.3528
Echinococcus multilocularis thioredoxin glutathione reductase 0.0042 0.0705 0.1273
Plasmodium vivax SET domain protein, putative 0.0029 0.0403 0.0344
Brugia malayi Sugar transporter family protein 0.0105 0.2147 0.3386
Onchocerca volvulus 0.0035 0.0534 0.0988
Trypanosoma brucei unspecified product 0.0014 0.0045 0.0161
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Onchocerca volvulus 0.0015 0.0066 0.0065
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0068
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0403 0.0566
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0485 0.0773
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0452 0.0671
Plasmodium vivax sugar transporter, putative 0.0015 0.0066 0.0005
Brugia malayi Cytochrome P450 family protein 0.0018 0.0131 0.0156
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0066 0.0051
Schistosoma mansoni protein kinase 0.0032 0.0467 0.0695
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0598 0.0952
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0467 0.0822
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0103 0.0132
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0327 0.412
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0188 0.0294
Plasmodium vivax glutathione reductase, putative 0.0042 0.0693 0.0635
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0595 0.0949
Brugia malayi MH1 domain containing protein 0.0016 0.0103 0.0112
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0595 0.086
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0747 0.1352
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0595 0.0949
Plasmodium falciparum thioredoxin reductase 0.0042 0.0693 0.0635
Onchocerca volvulus 0.0015 0.0066 0.0065
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0131 0.017
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0747 0.1352
Schistosoma mansoni sugar transporter 0.0015 0.0066 0.0053
Schistosoma mansoni DNA polymerase eta 0.002 0.0188 0.0248
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0389 0.062
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0747 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0573 0.1022
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0573 0.0825
Trypanosoma brucei glucose transporter, putative 0.0033 0.0477 0.6215
Brugia malayi hypothetical protein 0.0015 0.0066 0.0053
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0534 0.085
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0131 0.017
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0764 0.1383
Trypanosoma cruzi hexose transporter 0.0033 0.0477 0.6215
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0066 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0066 0.0106
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0068 0.049
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0327 0.0268
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.015 0.1635
Entamoeba histolytica hypothetical protein 0.0109 0.2235 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0068 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0188 0.2172
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0066 0.0106
Onchocerca volvulus 0.0015 0.0066 0.0065
Schistosoma mansoni smad 0.0016 0.0103 0.0112
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0068 0.0066
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0018 0.0131 0.0156
Onchocerca volvulus 0.0015 0.0066 0.0065

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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