Detailed information for compound 545534

Basic information

Technical information
  • TDR Targets ID: 545534
  • Name: (3S,3aS,7R,8aS,8bS)-6-(3-hydroxypropyl)-7-iso propenyl-3,3a-dimethyl-1,2,4,5,7,8,8a,8b-octa hydro-as-indacen-3-ol
  • MW: 304.467 | Formula: C20H32O2
  • H donors: 2 H acceptors: 2 LogP: 3.33 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCCC1=C2CC[C@]3([C@H]([C@@H]2C[C@@H]1C(=C)C)CC[C@]3(C)O)C
  • InChi: 1S/C20H32O2/c1-13(2)16-12-17-15(14(16)6-5-11-21)7-9-19(3)18(17)8-10-20(19,4)22/h16-18,21-22H,1,5-12H2,2-4H3/t16-,17-,18+,19+,20+/m1/s1
  • InChiKey: UYLCMHQZHUIMIY-SLHNCBLASA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (3S,3aS,7R,8aS,8bS)-6-(3-hydroxypropyl)-3,3a-dimethyl-7-prop-1-en-2-yl-1,2,4,5,7,8,8a,8b-octahydro-as-indacen-3-ol
  • 4a,17-dimethyl-A-homo-B,19-dinor-3,4-secoandrost-9-ene-3,17-diol
  • 145458-99-7
  • 4a,17-Dimethyl-A-homo-B,19-dinor-3,4-seco-5beta-androst-9-ene-3,17beta-diol
  • DMHDSA
  • as-Indacene-3-propanol, 1,2,4,5,5a,6,7,8,8a,8b-decahydro-6-hydroxy-5a,6-dimethyl-2-(1-methylethenyl)-, (2R-(2alpha,5abeta,6beta,8aalpha,8bbeta))-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ferritin light chain 0.0062 0.0334 0.0332
Brugia malayi AMP-binding enzyme family protein 0.0023 0.005 0.0248
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0007 0.001
Mycobacterium tuberculosis Probable lipase LipD 0.0113 0.0706 0.0997
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.005 0.0456
Loa Loa (eye worm) hypothetical protein 0.0023 0.005 0.0062
Mycobacterium tuberculosis Probable lipase LipE 0.0113 0.0706 0.0997
Echinococcus multilocularis musashi 0.0083 0.049 0.0487
Schistosoma mansoni hypothetical protein 0.0038 0.016 0.0158
Schistosoma mansoni intermediate filament proteins 0.0083 0.049 0.0487
Loa Loa (eye worm) hypothetical protein 0.0023 0.005 0.0062
Plasmodium falciparum diacylglycerol kinase, putative 0.0038 0.016 0.2445
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0339 0.4661
Leishmania major hypothetical protein, conserved 0.0113 0.0706 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.005 0.0061
Loa Loa (eye worm) hypothetical protein 0.0113 0.0706 0.0989
Echinococcus multilocularis smad 0.0017 0.0007 0.0005
Onchocerca volvulus 0.0038 0.016 0.0687
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0102 0.01
Mycobacterium tuberculosis Diacylglycerol kinase 0.0038 0.016 0.0226
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0139 0.09 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0624 0.0872
Trichomonas vaginalis ferritin, putative 0.0062 0.0334 0.1939
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0019 0.5
Mycobacterium tuberculosis Conserved protein 0.0113 0.0706 0.0997
Schistosoma mansoni lamin 0.0083 0.049 0.0487
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0125 0.0798 0.1127
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0113 0.0706 0.0988
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0062 0.0334 0.3344
Brugia malayi hypothetical protein 0.0066 0.0365 0.2053
Plasmodium falciparum thioredoxin reductase 0.0019 0.0019 0.019
Trypanosoma brucei trypanothione reductase 0.0055 0.0282 0.383
Echinococcus multilocularis sphingosine kinase 1 0.0982 0.7079 0.7079
Mycobacterium ulcerans bacterioferritin BfrB 0.0062 0.0334 0.0463
Schistosoma mansoni ferritin 0.0062 0.0334 0.0332
Trichomonas vaginalis esterase, putative 0.0113 0.0706 0.4221
Onchocerca volvulus 0.0241 0.1646 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0336 0.0334
Echinococcus granulosus tar DNA binding protein 0.0062 0.0336 0.0334
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0038 0.016 0.2051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0225 0.0223
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0113 0.0706 0.0989
Brugia malayi Intermediate filament tail domain containing protein 0.0083 0.049 0.2767
Schistosoma mansoni ferritin 0.0062 0.0334 0.0332
Echinococcus granulosus lamin 0.0083 0.049 0.0487
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.005 0.0071
Brugia malayi Bromodomain containing protein 0.0074 0.042 0.2367
Schistosoma mansoni ferritin 0.0062 0.0334 0.0332
Leishmania major trypanothione reductase 0.0055 0.0282 0.383
Brugia malayi beta-lactamase family protein 0.0113 0.0706 0.4006
Trypanosoma cruzi Sphingosine kinase 0.0038 0.016 0.2051
Leishmania major diacylglycerol kinase, putative 0.0038 0.016 0.2051
Echinococcus granulosus beta LACTamase domain containing family member 0.0113 0.0706 0.0704
Trypanosoma cruzi Sphingosine kinase 0.0038 0.016 0.2051
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0083 0.049 0.0683
Leishmania major cathepsin L-like protease 0.0063 0.0339 0.4661
Loa Loa (eye worm) hypothetical protein 0.0103 0.0632 0.0884
Loa Loa (eye worm) hypothetical protein 0.0113 0.0706 0.0989
Loa Loa (eye worm) intermediate filament protein 0.0083 0.049 0.0683
Schistosoma mansoni smad 0.0017 0.0007 0.0005
Loa Loa (eye worm) MH2 domain-containing protein 0.0255 0.1752 0.2467
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0019 0.0017
Brugia malayi Ceramide kinase 0.0038 0.016 0.0876
Toxoplasma gondii diacylglycerol kinase, putative 0.0038 0.016 0.2051
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0125 0.0798 0.1127
Loa Loa (eye worm) glutathione reductase 0.0055 0.0282 0.0389
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0038 0.016 0.0158
Echinococcus multilocularis lamin dm0 0.0083 0.049 0.0487
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0339 0.4661
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.016 0.2051
Loa Loa (eye worm) hypothetical protein 0.0038 0.016 0.0217
Echinococcus granulosus Diacylglycerol kinase theta 0.0038 0.016 0.0158
Brugia malayi Thioredoxin reductase 0.0055 0.0282 0.1576
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.005 0.0061
Echinococcus granulosus lamin dm0 0.0083 0.049 0.0487
Loa Loa (eye worm) hypothetical protein 0.0023 0.005 0.0062
Entamoeba histolytica hypothetical protein, conserved 0.0982 0.7079 1
Mycobacterium tuberculosis Probable hydrolase 0.0113 0.0706 0.0997
Brugia malayi diacylglycerol kinase 0.0038 0.016 0.0876
Brugia malayi beta-lactamase family protein 0.0113 0.0706 0.4006
Loa Loa (eye worm) hypothetical protein 0.0047 0.0225 0.0309
Plasmodium falciparum ataxin-2 like protein, putative 0.0103 0.0632 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0019 0.019
Mycobacterium leprae Probable lipase LipE 0.0113 0.0706 0.7713
Leishmania major hypothetical protein, conserved 0.0038 0.016 0.2051
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.0706 0.0704
Onchocerca volvulus 0.0113 0.0706 0.4108
Entamoeba histolytica diacylglycerol kinase, putative 0.0038 0.016 0.0156
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0138 0.0136
Echinococcus granulosus Diacylglycerol kinase zeta 0.0038 0.016 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.016 0.0866
Schistosoma mansoni apoferritin-2 0.0062 0.0334 0.0332
Echinococcus multilocularis Diacylglycerol kinase theta 0.0038 0.016 0.0158
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0339 0.4661
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0019 0.0019 1
Echinococcus granulosus ceramide kinase 0.0038 0.016 0.0158
Mycobacterium tuberculosis Conserved protein 0.0113 0.0706 0.0997
Onchocerca volvulus Ceramide kinase 1 homolog 0.0038 0.016 0.0687
Trichomonas vaginalis bmru protein, putative 0.0038 0.016 0.0866
Schistosoma mansoni zinc finger protein 0.0019 0.002 0.0018
Brugia malayi Pre-SET motif family protein 0.0212 0.1432 0.8167
Trypanosoma brucei hypothetical protein, conserved 0.0113 0.0706 1
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0282 0.383
Onchocerca volvulus 0.0083 0.049 0.2753
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0019 0.0017
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0019 0.0017
Loa Loa (eye worm) transcription factor SMAD2 0.0255 0.1752 0.2467
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0282 0.028
Echinococcus multilocularis ferritin 0.0062 0.0334 0.0332
Schistosoma mansoni bromodomain containing protein 0.0062 0.0335 0.0333
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0706 0.4221
Plasmodium falciparum ataxin-2 like protein, putative 0.0103 0.0632 1
Brugia malayi TAR-binding protein 0.0062 0.0336 0.1885
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0706 1
Toxoplasma gondii ABC1 family protein 0.0113 0.0706 1
Schistosoma mansoni Smad4 0.0017 0.0007 0.0005
Trichomonas vaginalis set domain proteins, putative 0.0241 0.1646 1
Trypanosoma cruzi diacylglycerol kinase, putative 0.0038 0.016 0.2051
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0046 0.0217 0.0215
Trypanosoma cruzi PAB1-binding protein , putative 0.0103 0.0632 0.8921
Trichomonas vaginalis sphingosine kinase, putative 0.0038 0.016 0.0866
Brugia malayi Eye-specific diacylglycerol kinase 0.0038 0.016 0.0876
Schistosoma mansoni smad1 5 8 and 0.0017 0.0007 0.0005
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0125 0.0798 0.1127
Brugia malayi Diacylglycerol kinase protein 2 0.0038 0.016 0.0876
Plasmodium vivax glutathione reductase, putative 0.0055 0.0282 0.3934
Schistosoma mansoni diacylglycerol kinase theta 0.0038 0.016 0.0158
Leishmania major cathepsin L-like protease 0.0063 0.0339 0.4661
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0339 0.4661
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0062 0.0334 1
Echinococcus granulosus tumor protein p63 0.0694 0.4965 0.4964
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.005 0.0456
Mycobacterium ulcerans hypothetical protein 0.0982 0.7079 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.016 0.0217
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0019 0.019
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0019 0.0027
Schistosoma mansoni sphingosine kinase A B 0.0982 0.7079 0.7079
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.031 0.0307
Brugia malayi AMP-binding enzyme family protein 0.0023 0.005 0.0248
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0094 0.0092
Schistosoma mansoni lamin 0.0083 0.049 0.0487
Echinococcus multilocularis Smad4 0.0017 0.0007 0.0005
Echinococcus multilocularis zinc finger protein 0.0019 0.002 0.0018
Mycobacterium tuberculosis Probable esterase LipL 0.0113 0.0706 0.0997
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0225 0.0223
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.0206 0.0282
Loa Loa (eye worm) hypothetical protein 0.004 0.0173 0.0235
Leishmania major hypothetical protein, conserved 0.0103 0.0632 0.8921
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0019 0.0017
Leishmania major hypothetical protein, conserved 0.0038 0.016 0.2051
Schistosoma mansoni ferritin light chain 0.0062 0.0334 0.0332
Brugia malayi AMP-binding enzyme family protein 0.0023 0.005 0.0248
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0007 0.0005
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.005 0.0061
Loa Loa (eye worm) hypothetical protein 0.0038 0.0156 0.0211
Mycobacterium ulcerans diacylglycerol kinase 0.0038 0.016 0.0216
Brugia malayi intermediate filament protein 0.0083 0.049 0.2767
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0174 0.0172
Echinococcus granulosus smad 0.0017 0.0007 0.0005
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0042 0.004
Mycobacterium ulcerans hypothetical protein 0.0023 0.005 0.0061
Trypanosoma brucei diacylglycerol kinase, putative 0.0038 0.016 0.2051
Plasmodium falciparum glutathione reductase 0.0019 0.0019 0.019
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0282 0.3934
Onchocerca volvulus 0.0083 0.049 0.2753
Echinococcus granulosus Smad4 0.0017 0.0007 0.0005
Echinococcus multilocularis tumor protein p63 0.0694 0.4965 0.4964
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0113 0.0706 0.0997
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.005 0.0061
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0038 0.016 0.0866
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0336 0.0465
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0336 0.0465
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.005 0.0061
Echinococcus multilocularis microtubule associated protein 2 0.1381 1 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0138 0.0136
Mycobacterium ulcerans bacterioferritin BfrA 0.0062 0.0334 0.0463
Plasmodium falciparum glutathione reductase 0.0055 0.0282 0.4401
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0706 0.4221
Loa Loa (eye worm) RNA binding protein 0.0062 0.0336 0.0465
Mycobacterium ulcerans beta-lactamase 0.0113 0.0706 0.0988
Plasmodium vivax diacylglycerol kinase, putative 0.0038 0.016 0.2186
Loa Loa (eye worm) hypothetical protein 0.0982 0.7079 1
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0038 0.016 0.0158
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0339 0.4661
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0113 0.0706 0.4006
Schistosoma mansoni diacylglycerol kinase theta 0.0038 0.016 0.0158
Plasmodium vivax SET domain protein, putative 0.003 0.0102 0.1359
Mycobacterium tuberculosis Conserved protein 0.0982 0.7079 1
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0706 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.005 0.0061
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0299 0.408
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0038 0.016 0.2051
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0336 0.1885
Leishmania major sphingosine kinase A, B, putative 0.0038 0.016 0.2051
Loa Loa (eye worm) hypothetical protein 0.0113 0.0706 0.0989
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0007 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0102 0.01
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0336 0.0334
Loa Loa (eye worm) hypothetical protein 0.0039 0.0163 0.0221
Loa Loa (eye worm) hypothetical protein 0.0113 0.0706 0.0989
Entamoeba histolytica diacylglycerol kinase, putative 0.0038 0.016 0.0156
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.005 0.0456
Loa Loa (eye worm) hypothetical protein 0.0042 0.0187 0.0255
Toxoplasma gondii LsmAD domain-containing protein 0.0103 0.0632 0.8921
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0339 0.4661
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.0706 0.0704
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0282 0.028
Mycobacterium ulcerans hypothetical protein 0.0113 0.0706 0.0988
Schistosoma mansoni ferritin 0.0062 0.0334 0.0332
Echinococcus granulosus sphingosine kinase 1 0.0982 0.7079 0.7079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0339 0.4661
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0336 0.0334
Schistosoma mansoni apoferritin-2 0.0062 0.0334 0.0332
Echinococcus multilocularis expressed protein 0.0062 0.0334 0.0332
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.0706 0.4221
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0139 0.09 0.1272
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0038 0.016 0.0866
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0339 0.4661
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0038 0.016 0.0158
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0102 0.01
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0336 0.0334
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0038 0.016 0.0866
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.1432 0.2015
Schistosoma mansoni smad1 5 8 and 0.0017 0.0007 0.0005
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0102 0.121
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.0206 0.1143
Echinococcus multilocularis ceramide kinase 0.0038 0.016 0.0158
Schistosoma mansoni hypothetical protein 0.002 0.0028 0.0026
Trichomonas vaginalis diacylglycerol kinase, putative 0.0038 0.016 0.0866
Loa Loa (eye worm) hypothetical protein 0.0039 0.0163 0.0221
Treponema pallidum bacterioferrin (TpF1) 0.0062 0.0334 1
Leishmania major cathepsin L-like protease 0.0063 0.0339 0.4661
Trypanosoma cruzi diacylglycerol kinase, putative 0.0038 0.016 0.2051
Trypanosoma brucei PAB1-binding protein , putative 0.0103 0.0632 0.8921
Toxoplasma gondii thioredoxin reductase 0.0055 0.0282 0.383
Brugia malayi hypothetical protein 0.0103 0.0632 0.3581
Plasmodium falciparum thioredoxin reductase 0.0055 0.0282 0.4401
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0139 0.09 0.1272
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.0706 0.4221
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0339 0.4661
Brugia malayi Bromodomain containing protein 0.0038 0.0155 0.0851
Echinococcus granulosus ferritin 0.0062 0.0334 0.0332
Loa Loa (eye worm) diacylglycerol kinase 2 0.0038 0.016 0.0217
Mycobacterium leprae conserved hypothetical protein 0.0113 0.0706 0.7713
Brugia malayi Pre-SET motif family protein 0.003 0.0102 0.0545
Onchocerca volvulus 0.0113 0.0706 0.4108
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0125 0.0798 0.8794
Brugia malayi RNA binding protein 0.0062 0.0336 0.1885
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0038 0.016 0.0217
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0706 0.4221
Mycobacterium ulcerans esterase/lipase LipP 0.0113 0.0706 0.0988
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0339 0.4661
Brugia malayi MH2 domain containing protein 0.0255 0.1752 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0339 0.4661
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0339 0.4661
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0042 0.004
Trichomonas vaginalis diacylglycerol kinase, putative 0.0038 0.016 0.0866
Brugia malayi hypothetical protein 0.0038 0.016 0.0876
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0042 0.004
Schistosoma mansoni microtubule-associated protein tau 0.1381 1 1
Trichomonas vaginalis sphingosine kinase, putative 0.0038 0.016 0.0866
Loa Loa (eye worm) ceramide kinase 0.0038 0.016 0.0217
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0721 0.516 0.7289
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0113 0.0706 0.0997
Loa Loa (eye worm) hypothetical protein 0.0083 0.049 0.0683
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0174 0.0172
Brugia malayi diacylglycerol kinase 0.0038 0.016 0.0876
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0019 0.017
Entamoeba histolytica diacylglycerol kinase, putative 0.0038 0.016 0.0156
Loa Loa (eye worm) hypothetical protein 0.007 0.0389 0.0541
Trypanosoma brucei Sphingosine kinase 0.0038 0.016 0.2051
Leishmania major diacylglycerol kinase-like protein 0.0038 0.016 0.2051
Schistosoma mansoni hypothetical protein 0.0046 0.0217 0.0215
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.005 0.0071
Echinococcus granulosus expressed protein 0.0062 0.0334 0.0332
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0336 0.0334
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0062 0.0334 0.0472
Mycobacterium tuberculosis Probable dehydrogenase 0.0125 0.0798 0.1127
Mycobacterium ulcerans lipase LipD 0.0113 0.0706 0.0988
Plasmodium vivax diacylglycerol kinase, putative 0.0038 0.016 0.2186
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0038 0.016 0.0158
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0282 0.0398
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0125 0.0798 0.1127
Onchocerca volvulus 0.0102 0.0624 0.3593
Loa Loa (eye worm) hypothetical protein 0.0113 0.0706 0.0989
Brugia malayi beta-lactamase 0.0113 0.0706 0.4006
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.016 0.2051
Plasmodium falciparum diacylglycerol kinase, putative 0.0038 0.016 0.2445
Loa Loa (eye worm) hypothetical protein 0.004 0.0174 0.0236
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0038 0.016 0.2051
Schistosoma mansoni sphingoid long chain base kinase 0.0982 0.7079 0.7079
Brugia malayi PHD-finger family protein 0.0024 0.0059 0.0298
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0019 0.017
Mycobacterium tuberculosis Conserved protein 0.0113 0.0706 0.0997
Schistosoma mansoni cellular tumor antigen P53 0.0102 0.0624 0.0622
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0046 0.0217 0.0215
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0241 0.3229
Loa Loa (eye worm) hypothetical protein 0.0082 0.0478 0.0667
Brugia malayi glutathione reductase 0.0055 0.0282 0.1576
Echinococcus multilocularis beta LACTamase domain containing family member 0.0113 0.0706 0.0704
Plasmodium vivax hypothetical protein, conserved 0.0113 0.0706 1
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0282 0.0389
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0019 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0225 0.0223
Mycobacterium tuberculosis Probable oxidoreductase 0.0139 0.09 0.1272
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0225 0.0223
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0028 0.003
Loa Loa (eye worm) hypothetical protein 0.0113 0.0706 0.0989
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0038 0.016 0.0158
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0019 0.0069
Loa Loa (eye worm) beta-lactamase 0.0113 0.0706 0.0989
Echinococcus granulosus zinc finger protein 0.0019 0.002 0.0018
Plasmodium vivax ataxin-2 like protein, putative 0.0103 0.0632 0.8939
Mycobacterium tuberculosis Probable reductase 0.0125 0.0798 0.1127
Trypanosoma cruzi PAB1-binding protein , putative 0.0103 0.0632 0.8921
Schistosoma mansoni smad1 5 8 and 0.0017 0.0007 0.0005
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0007 0.0005
Echinococcus multilocularis lamin 0.0083 0.049 0.0487
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0336 0.0334
Onchocerca volvulus 0.0113 0.0706 0.4108
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0038 0.016 0.2051
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0339 0.4661
Trichomonas vaginalis bmru protein, putative 0.0038 0.016 0.0866
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0339 0.4661
Onchocerca volvulus 0.003 0.0102 0.0325
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.005 0.0061
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0038 0.016 0.2051
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0007 0.0005
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0038 0.016 0.2051
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.031 0.0307
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0062 0.0334 0.0472
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0019 0.0017
Entamoeba histolytica diacylglycerol kinase, putative 0.0038 0.016 0.0156
Loa Loa (eye worm) hypothetical protein 0.0038 0.016 0.0217
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0339 0.4661
Echinococcus granulosus intermediate filament protein 0.0083 0.049 0.0487
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0113 0.0706 0.0997
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0007 0.0005

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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