Detailed information for compound 546281

Basic information

Technical information
  • TDR Targets ID: 546281
  • Name: N-[(1R,2S)-2-aminocyclohexyl]-3,4-dichloro-be nzamide hydrochloride
  • MW: 323.646 | Formula: C13H17Cl3N2O
  • H donors: 2 H acceptors: 1 LogP: 3.65 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N[C@H]1CCCC[C@H]1NC(=O)c1ccc(c(c1)Cl)Cl.Cl
  • InChi: 1S/C13H16Cl2N2O.ClH/c14-9-6-5-8(7-10(9)15)13(18)17-12-4-2-1-3-11(12)16;/h5-7,11-12H,1-4,16H2,(H,17,18);1H/t11-,12+;/m0./s1
  • InChiKey: AHVOGJYCMMZOSD-ZVWHLABXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(1R,2S)-2-aminocyclohexyl]-3,4-dichlorobenzamide hydrochloride
  • N-[(1R,2S)-2-azanylcyclohexyl]-3,4-dichloro-benzamide hydrochloride
  • N-(2-aminocyclohexyl)-3,4-dichlorobenzamide
  • 147934-28-9
  • U 83892E
  • U-83892E

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0019 0.0047 0.0166
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0072 0.0824 0.0824
Trypanosoma brucei glycerol uptake protein, putative 0.0021 0.007 0.025
Echinococcus multilocularis neuropeptide s receptor 0.0472 0.6675 0.6675
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0019 0.0047 0.0062
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0312 0.0428
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0208 0.2821 0.3755
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0019 0.0047 0.0166
Brugia malayi hypothetical protein 0.0035 0.0276 0.0379
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0441 0.0441
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0441 0.0605
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0312 0.1106
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0284 0.0322
Entamoeba histolytica hypothetical protein 0.0035 0.0284 0.1648
Plasmodium falciparum glutathione reductase 0.0208 0.2821 1
Trypanosoma cruzi NADH dehydrogenase, putative 0.0019 0.0047 0.0166
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0019 0.0047 0.0166
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.073 0.073
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0019 0.0047 0.0062
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0021 0.007 0.007
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0476 0.6734 0.8965
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0476 0.6734 0.8965
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0093 0.0595
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0513 0.7283 1
Plasmodium vivax SET domain protein, putative 0.0066 0.073 0.2588
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0276 0.0276
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0072 0.0824 0.2922
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0019 0.0047 0.0047
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.1835 0.1835
Toxoplasma gondii exonuclease III APE 0.0037 0.0312 0.1106
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0047 0.0047
Schistosoma mansoni glutamate synthase 0.0019 0.0047 0.0047
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0097
Schistosoma mansoni lipoxygenase 0.008 0.0943 0.0943
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0324 0.1921
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.145 0.145
Schistosoma mansoni hypothetical protein 0.0019 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0172 0.2279 0.2279
Trichomonas vaginalis glutathione reductase, putative 0.0072 0.0824 0.1055
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0481 0.066
Leishmania major glycerol uptake protein, putative 0.0021 0.007 0.025
Trypanosoma cruzi glycerol uptake protein, putative 0.0021 0.007 0.025
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0374 0.1327
Entamoeba histolytica hypothetical protein 0.0035 0.0276 0.1591
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0019 0.0047 0.0064
Brugia malayi Hhat protein 0.0021 0.007 0.0097
Leishmania major hypothetical protein, conserved 0.0028 0.017 0.0603
Brugia malayi diacylglycerol acyltransferase 0.0021 0.007 0.0097
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0021 0.007 0.007
Trypanosoma brucei NADH dehydrogenase 0.0019 0.0047 0.0166
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0019 0.0047 0.0047
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0072 0.0824 0.2922
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0284 0.1008
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.017 0.0603
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0019 0.0047 0.0166
Brugia malayi Doublecortin family protein 0.0019 0.0047 0.0065
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.073 0.2588
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0072 0.0824 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0441 0.0441
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0118 0.1488 0.1488
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0118 0.1488 0.1488
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0093 0.033
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0093 0.0128
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0072 0.0824 1
Trypanosoma cruzi GUP1, putative 0.0021 0.007 0.025
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0118 0.1488 0.5277
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0072 0.0824 0.2922
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.017 0.0603
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0019 0.0047 0.0064
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0072 0.0824 0.2922
Echinococcus granulosus sterol O acyltransferase 1 0.0021 0.007 0.007
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0118 0.1488 0.2044
Echinococcus multilocularis transcription factor btf3 0.0035 0.0284 0.0284
Trypanosoma cruzi glycerol uptake protein, putative 0.0021 0.007 0.025
Loa Loa (eye worm) glutathione reductase 0.0208 0.2821 0.3873
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0019 0.0047 0.0047
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0476 0.6734 0.8965
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0019 0.0047 0.0047
Loa Loa (eye worm) thioredoxin reductase 0.0208 0.2821 0.3873
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0118 0.1488 0.5277
Trypanosoma cruzi GUP1, putative 0.0021 0.007 0.025
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0093 0.033
Mycobacterium tuberculosis Probable dehydrogenase 0.0476 0.6734 0.8965
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0019 0.0047 0.0166
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.017 0.0603
Entamoeba histolytica vacuolar protein sorting 26 0.0021 0.007 0.0165
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0441 0.0441
Echinococcus multilocularis microtubule associated protein 2 0.0698 1 1
Loa Loa (eye worm) hhat protein 0.0021 0.007 0.0097
Toxoplasma gondii hypothetical protein 0.0021 0.007 0.025
Leishmania major hypothetical protein, conserved 0.0021 0.007 0.025
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0312 0.036
Brugia malayi hypothetical protein 0.0019 0.0047 0.0065
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0441 0.0441
Brugia malayi hypothetical protein 0.0019 0.0047 0.0065
Loa Loa (eye worm) hypothetical protein 0.0066 0.073 0.1002
Trypanosoma cruzi trypanothione reductase, putative 0.0072 0.0824 0.2922
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0276 0.0276
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.1777 0.1777
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0019 0.0047 0.0166
Onchocerca volvulus 0.0019 0.0047 0.0001
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0513 0.0704
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0072 0.0824 0.1132
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0047 0.0166
Leishmania major glycerol uptake protein, putative 0.0021 0.007 0.025
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0072 0.0824 0.2922
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0093 0.0128
Echinococcus granulosus transcription factor btf3 0.0035 0.0284 0.0284
Entamoeba histolytica hypothetical protein 0.0035 0.0276 0.1591
Echinococcus multilocularis thioredoxin glutathione reductase 0.0208 0.2821 0.2821
Schistosoma mansoni hypothetical protein 0.0049 0.0481 0.0481
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0118 0.1488 1
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0284 0.1008
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.017 0.0603
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.073 0.073
Loa Loa (eye worm) hypothetical protein 0.0118 0.1488 0.2044
Echinococcus granulosus glutamate synthase 0.0019 0.0047 0.0047
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0312 0.1839
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0374 0.0445
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0047 0.0166
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0019 0.0047 0.0062
Trichomonas vaginalis transmembrane protein nessy, putative 0.0021 0.007 0.0032
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0312 0.0428
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0441 0.0441
Leishmania major hypothetical protein, conserved 0.0019 0.0047 0.0166
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0065
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0118 0.1488 0.1956
Trypanosoma brucei glycerol uptake protein, putative 0.0021 0.007 0.025
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0072 0.0824 0.0824
Entamoeba histolytica hypothetical protein 0.0035 0.0276 0.1591
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.073 0.073
Onchocerca volvulus 0.0019 0.0047 0.0001
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0118 0.1488 0.1488
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0312 0.1106
Loa Loa (eye worm) MBOAT family protein 0.0021 0.007 0.0097
Leishmania major trypanothione reductase 0.0208 0.2821 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0459 0.6489 0.891
Echinococcus granulosus o acyltransferase membrane bound domain 0.0021 0.007 0.007
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0284 0.1008
Loa Loa (eye worm) programmed cell death 8 0.0019 0.0047 0.0064
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0324 0.1147
Treponema pallidum NADH oxidase 0.0072 0.0824 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0208 0.2821 0.2821
Plasmodium falciparum thioredoxin reductase 0.0072 0.0824 0.2922
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0072 0.0824 0.2922
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0021 0.007 0.0165
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0072 0.0824 0.2922
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0021 0.007 0.025
Echinococcus multilocularis muscleblind protein 0.048 0.6796 0.6796
Echinococcus multilocularis neuropeptide receptor A26 0.0472 0.6675 0.6675
Plasmodium falciparum ferrodoxin reductase-like protein 0.0019 0.0047 0.0166
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0072 0.0824 0.2922
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0241 0.3302 0.3302
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0019 0.0047 0.0047
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0021 0.007 0.007
Echinococcus multilocularis glutamate synthase 0.0019 0.0047 0.0047
Echinococcus granulosus geminin 0.0172 0.2279 0.2279
Echinococcus granulosus muscleblind protein 0.048 0.6796 0.6796
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0312 0.341
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0284 0.0322
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0021 0.007 0.007
Schistosoma mansoni glutamate synthase 0.0019 0.0047 0.0047
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0019 0.0047 0.0166
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0312 0.1106
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0072 0.0824 0.2922
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0047 0.0065
Trypanosoma brucei trypanothione reductase 0.0208 0.2821 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.0021 0.007 0.007
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0021 0.007 0.025
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0284 0.1008
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0312 0.0312
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0312 0.341
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.007 0.0032
Onchocerca volvulus 0.0021 0.007 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0441 0.0441
Brugia malayi Muscleblind-like protein 0.048 0.6796 0.9331
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.073 0.073
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0021 0.007 0.007
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0312 0.1839
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0072 0.0824 0.0824
Leishmania major glycerol uptake protein, putative 0.0021 0.007 0.025
Loa Loa (eye worm) hypothetical protein 0.005 0.0499 0.0685
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0374 0.0374
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0072 0.0824 0.2922
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0072 0.0824 0.2922
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.3273 0.3273
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0047 0.0166
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0019 0.0047 0.0047
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0019 0.0047 0.0062
Brugia malayi MBOAT family protein 0.0021 0.007 0.0097
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0072 0.0824 0.2922
Echinococcus multilocularis zinc finger protein 0.0221 0.2998 0.2998
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0019 0.0047 0.0166
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0374 0.1327
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0072 0.0824 0.2922
Loa Loa (eye worm) hypothetical protein 0.048 0.6796 0.9331
Brugia malayi MBOAT family protein 0.0021 0.007 0.0097
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0312 0.341
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0312 0.1106
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0284 0.0322
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0276 0.0276
Schistosoma mansoni polycystin 1-related 0.0019 0.0047 0.0047
Leishmania major cytochrome p450-like protein 0.0022 0.0093 0.033
Entamoeba histolytica hypothetical protein 0.0021 0.007 0.0165
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0021 0.007 0.007
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0019 0.0047 0.0166
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0284 0.1008
Echinococcus granulosus o acyltransferase membrane bound domain 0.0021 0.007 0.007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0312 0.1106
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0072 0.0824 0.2922
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0072 0.0824 1
Leishmania major glycerol uptake protein, putative 0.0021 0.007 0.025
Brugia malayi MBOAT family protein 0.0021 0.007 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.007 0.0032
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0118 0.1488 0.5277
Trichomonas vaginalis porcupine, putative 0.0021 0.007 0.0032
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0072 0.0824 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0441 0.0441
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0047 0.0166
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0021 0.007 0.007
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0374 0.1327
Brugia malayi Pre-SET motif family protein 0.0459 0.6489 0.891
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0021 0.007 0.007
Schistosoma mansoni sulfide quinone reductase 0.0019 0.0047 0.0047
Leishmania major hypothetical protein, conserved 0.0019 0.0047 0.0166
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0019 0.0047 0.0047
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0093 0.0128
Schistosoma mansoni lipoxygenase 0.0115 0.145 0.145
Loa Loa (eye worm) MBOAT family protein 0.0241 0.3302 0.4535
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0529 0.7512 1
Plasmodium vivax glutathione reductase, putative 0.0208 0.2821 1
Trypanosoma cruzi trypanothione reductase, putative 0.0208 0.2821 1
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0019 0.0047 0.0062
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0529 0.7512 1
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0047 0.0047
Echinococcus granulosus neuropeptide s receptor 0.0472 0.6675 0.6675
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0241 0.3302 0.3302
Echinococcus multilocularis tumor protein p63 0.0342 0.4777 0.4777
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0441 0.0605
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0019 0.0047 0.0047
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0021 0.007 0.025
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0047 0.0047
Entamoeba histolytica hypothetical protein 0.0035 0.0276 0.1591
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0047 0.0168
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.1835 0.252
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0097
Mycobacterium tuberculosis Probable oxidoreductase 0.0529 0.7512 1
Onchocerca volvulus 0.0522 0.7418 1
Loa Loa (eye worm) MBOAT family protein 0.0021 0.007 0.0097
Schistosoma mansoni microtubule-associated protein tau 0.0698 1 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0374 0.0445
Echinococcus multilocularis muscleblind protein 1 0.048 0.6796 0.6796
Entamoeba histolytica hypothetical protein, conserved 0.0021 0.007 0.0165
Brugia malayi follicle stimulating hormone receptor 0.0513 0.7283 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0097
Giardia lamblia NADH oxidase lateral transfer candidate 0.0072 0.0824 0.5394
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0047 0.0047
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0021 0.007 0.007
Trypanosoma cruzi glycerol uptake protein, putative 0.0021 0.007 0.025
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.073 0.073
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0021 0.007 0.0097
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.017 0.0603
Echinococcus granulosus RUN 0.0019 0.0047 0.0047
Echinococcus multilocularis sterol O acyltransferase 1 0.0021 0.007 0.007
Toxoplasma gondii selenide, water dikinase 0.0019 0.0047 0.0166
Brugia malayi MBOAT family protein 0.0241 0.3302 0.4535
Brugia malayi hypothetical protein 0.0018 0.0027 0.0037
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0021 0.007 0.025
Plasmodium falciparum glutathione reductase 0.0072 0.0824 0.2922
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0047 0.0166
Trypanosoma cruzi NADH dehydrogenase, putative 0.0019 0.0047 0.0166
Echinococcus granulosus tumor protein p63 0.0342 0.4777 0.4777
Schistosoma mansoni ap endonuclease 0.0037 0.0312 0.0312
Brugia malayi hypothetical protein 0.0028 0.017 0.0234
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0019 0.0047 0.0166
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0312 0.0415
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0072 0.0824 0.2922
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0324 0.1921
Plasmodium falciparum thioredoxin reductase 0.0208 0.2821 1
Schistosoma mansoni sterol O-acyltransferase 1 0.0021 0.007 0.007
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0476 0.6734 0.8965
Schistosoma mansoni survival motor neuron protein 0.0049 0.0481 0.0481
Loa Loa (eye worm) hypothetical protein 0.0028 0.017 0.0234
Loa Loa (eye worm) acetyltransferase 0.0141 0.1835 0.252
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0284 0.039
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0476 0.6734 0.8958
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.0695 0.0695
Echinococcus granulosus zinc finger protein 0.0221 0.2998 0.2998
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.3273 0.3273
Treponema pallidum alginate O-acetylation protein (algI) 0.0021 0.007 0.0306
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0118 0.1488 0.5277
Schistosoma mansoni hypothetical protein 0.0172 0.2279 0.2279
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0021 0.007 0.007
Brugia malayi Pre-SET motif family protein 0.0066 0.073 0.1002
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0021 0.007 0.0165
Brugia malayi Cytochrome P450 family protein 0.0022 0.0093 0.0128
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0529 0.7512 1
Echinococcus multilocularis RUN 0.0019 0.0047 0.0047
Leishmania major glycerol uptake protein, putative 0.0021 0.007 0.025
Plasmodium vivax thioredoxin reductase, putative 0.0208 0.2821 1
Echinococcus multilocularis geminin 0.0172 0.2279 0.2279
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.1835 0.1835
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0072 0.0824 0.2922
Brugia malayi Thioredoxin reductase 0.0208 0.2821 0.3873
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0312 0.1106
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.017 0.0603
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0065
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.017 0.0603
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0284 0.1648
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0019 0.0047 0.0047
Trichomonas vaginalis set domain proteins, putative 0.0522 0.7418 1
Mycobacterium tuberculosis Probable reductase 0.0476 0.6734 0.8965
Leishmania major basic transcription factor 3a, putative 0.0035 0.0284 0.1008
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0019 0.0047 0.0047
Brugia malayi Cytochrome P450 family protein 0.0022 0.0093 0.0128
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0118 0.1488 0.1488
Toxoplasma gondii thioredoxin reductase 0.0208 0.2821 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.073 0.073
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.007 0.0032
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0072 0.0824 0.2922
Schistosoma mansoni zinc finger protein 0.0241 0.3302 0.3302
Loa Loa (eye worm) hhat protein 0.0021 0.007 0.0097
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0021 0.007 0.007
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0019 0.0047 0.0166
Loa Loa (eye worm) hypothetical protein 0.0239 0.3273 0.4494
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0019 0.0047 0.0064
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0021 0.007 0.007
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0072 0.0824 0.2922
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0019 0.0047 0.0166
Onchocerca volvulus 0.005 0.0499 0.0614
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0072 0.0824 0.1097
Echinococcus granulosus ubiquitin specific protease 41 0.0118 0.1488 0.1488
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0021 0.007 0.007
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0047 0.0047
Brugia malayi hypothetical protein 0.0239 0.3273 0.4494
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0019 0.0047 0.0166
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0047 0.0166
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0072 0.0824 0.2922
Plasmodium vivax ferrodoxin reductase, putative 0.0019 0.0047 0.0166
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.073 0.073
Schistosoma mansoni ap endonuclease 0.0037 0.0312 0.0312
Schistosoma mansoni rab6-interacting 0.0019 0.0047 0.0047
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0021 0.007 0.0097
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0072 0.0824 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0118 0.1488 0.1956
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0047 0.0166
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0019 0.0047 0.0166
Brugia malayi Cytochrome P450 family protein 0.0051 0.0513 0.0704
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0312 0.0312
Schistosoma mansoni hypothetical protein 0.0019 0.0047 0.0047
Schistosoma mansoni rab6-interacting 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.048 0.6796 0.9331
Onchocerca volvulus 0.0066 0.073 0.0927
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0021 0.007 0.007
Trichomonas vaginalis mercuric reductase, putative 0.0072 0.0824 0.1055
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0019 0.0047 0.0166
Schistosoma mansoni transcription factor btf3 0.0035 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0064
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0019 0.0047 0.0062
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0019 0.0047 0.0064
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0021 0.007 0.007
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.145 0.145
Toxoplasma gondii NADPH-glutathione reductase 0.0072 0.0824 0.2922
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0019 0.0047 0.0166
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0021 0.007 0.007
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0118 0.1488 0.1488
Leishmania major hypothetical protein, conserved 0.0019 0.0047 0.0166
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0021 0.007 0.007
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0021 0.007 0.0165
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0312 0.036
Brugia malayi beta-NAC-like protein 0.0035 0.0284 0.039
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0053 0.0543 0.0746
Schistosoma mansoni loxhd1 0.0019 0.0047 0.0047
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0499 0.0499
Brugia malayi MBOAT family protein 0.0021 0.007 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.1488 0.1956
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0072 0.0824 0.2922
Schistosoma mansoni sulfide quinone reductase 0.0019 0.0047 0.0047
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0021 0.007 0.007
Brugia malayi glutamate synthase 0.0019 0.0047 0.0064
Leishmania major NADH dehydrogenase, putative 0.0019 0.0047 0.0166
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0072 0.0824 0.2922
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0284 0.1008
Schistosoma mansoni glutamate synthase 0.0019 0.0047 0.0047
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0118 0.1488 1
Echinococcus granulosus neuropeptide receptor A26 0.0472 0.6675 0.6675
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0047 0.0168
Schistosoma mansoni hypothetical protein 0.0035 0.0276 0.0276
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0118 0.1488 0.1488
Brugia malayi glutathione reductase 0.0208 0.2821 0.3873
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0053 0.0543 0.0746
Onchocerca volvulus 0.0049 0.0481 0.0589
Echinococcus multilocularis ubiquitin specific protease 41 0.0118 0.1488 0.1488
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0019 0.0047 0.0047
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0072 0.0824 1
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0093 0.033
Schistosoma mansoni disulfide oxidoreductase 0.0019 0.0047 0.0047

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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