Detailed information for compound 546454

Basic information

Technical information
  • TDR Targets ID: 546454
  • Name: (2R,4S)-2-[[(2S,3aS,7aR)-2,3,3a,4,5,6,7,7a-oc tahydro-1H-indole-2-carbonyl]-[(2R)-4-propoxy pyrrolidine-2-carbonyl]amino]-4-amino-2-(3-gu anidinopropyl)-5-hydroxy-3-oxo-pentanoic acid
  • MW: 567.678 | Formula: C26H45N7O7
  • H donors: 7 H acceptors: 6 LogP: -3.74 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 3
  • SMILES: CCCOC1CN[C@H](C1)C(=O)N([C@](C(=O)[C@H](CO)N)(C(=O)O)CCCN=C(N)N)C(=O)[C@@H]1C[C@H]2[C@H](N1)CCCC2
  • InChi: 1S/C26H45N7O7/c1-2-10-40-16-12-19(31-13-16)22(36)33(23(37)20-11-15-6-3-4-7-18(15)32-20)26(24(38)39,21(35)17(27)14-34)8-5-9-30-25(28)29/h15-20,31-32,34H,2-14,27H2,1H3,(H,38,39)(H4,28,29,30)/t15-,16?,17-,18+,19+,20-,26+/m0/s1
  • InChiKey: AOXVGYLNAYOFJH-RCSXMCSBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R,4S)-2-[[[(2S,3aS,7aR)-2,3,3a,4,5,6,7,7a-octahydro-1H-indol-2-yl]-oxomethyl]-[oxo-[(2R)-4-propoxy-2-pyrrolidinyl]methyl]amino]-4-amino-2-(3-guanidinopropyl)-5-hydroxy-3-oxopentanoic acid
  • (2R,4S)-2-[[(2S,3aS,7aR)-2,3,3a,4,5,6,7,7a-octahydro-1H-indol-2-yl]carbonyl-[(2R)-4-propoxypyrrolidin-2-yl]carbonyl-amino]-4-azanyl-2-[3-[bis(azanyl)methylideneamino]propyl]-5-hydroxy-3-oxo-pentanoic acid
  • (2R,4S)-2-[[(2S,3aS,7aR)-2,3,3a,4,5,6,7,7a-octahydro-1H-indole-2-carbonyl]-[(2R)-4-propoxyprolyl]amino]-4-amino-2-(3-guanidinopropyl)-5-hydroxy-3-keto-valeric acid
  • (2R,4S)-2-[[(2S,3aS,7aR)-2,3,3a,4,5,6,7,7a-octahydro-1H-indole-2-carbonyl]-[(2R)-4-propoxypyrrolidine-2-carbonyl]amino]-4-amino-2-[3-(diaminomethylideneamino)propyl]-5-hydroxy-3-oxopentanoic acid
  • seryl-HYPE(transpropyl)-octahydroindole-2-carbonyl-arginine
  • (2R,4S)-2-[[(2S,3aS,7aR)-2,3,3a,4,5,6,7,7a-octahydro-1H-indole-2-carbonyl]-[(2R)-4-propoxypyrrolidine-2-carbonyl]amino]-4-amino-2-(3-guanidinopropyl)-5-hydroxy-3-keto-valeric acid
  • (2R,4S)-2-[[(2S,3aS,7aR)-2,3,3a,4,5,6,7,7a-octahydro-1H-indol-2-yl]carbonyl-[(2R)-4-propoxypyrrolidin-2-yl]carbonyl-amino]-4-amino-2-[3-(diaminomethylideneamino)propyl]-5-hydroxy-3-oxo-pentanoic acid
  • 148383-08-8
  • Ser-hype-oic-arg

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptide s receptor 0.0476 0.1706 0.1706
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0034 0.039
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0073 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0073 0.0231 0.0231
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0094 0.1608
Leishmania major glycerol uptake protein, putative 0.0236 0.0829 1
Schistosoma mansoni cpg binding protein 0.009 0.0293 0.0293
Loa Loa (eye worm) cytochrome P450 0.0014 0.0015 0.0015
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0021 0.0041 0.0523
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0147 0.0147
Brugia malayi MAP kinase sur-1 0.005 0.0147 0.0147
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0032 0.0208
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0127 0.0127
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0119 0.1396
Loa Loa (eye worm) hypothetical protein 0.0032 0.008 0.008
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0021 0.0041 0.0523
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0047 0.0391
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0147 0.0147
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0184 0.0184
Brugia malayi Cytochrome P450 family protein 0.0052 0.0154 0.0154
Brugia malayi CXXC zinc finger family protein 0.0085 0.0275 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0034 0.039
Brugia malayi hypothetical protein 0.002 0.0036 0.0036
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0236 0.0829 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0032 0.0032
Leishmania major glycerol uptake protein, putative 0.0236 0.0829 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0094 0.1104
Schistosoma mansoni hypothetical protein 0.0014 0.0015 0.0015
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0225 0.0225
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0032 0.0208
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0073 0.0231 0.2657
Echinococcus multilocularis 0.0014 0.0015 0.0015
Schistosoma mansoni myst-related protein 0.001 0.0001 0.0001
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0021 0.0041 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0034 0.039
Schistosoma mansoni ap endonuclease 0.0019 0.0032 0.0032
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0036 0.0036
Trichomonas vaginalis set domain proteins, putative 0.0239 0.084 1
Mycobacterium ulcerans hypothetical protein 0.0036 0.0094 0.1608
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0184 0.3431
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.008 0.008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0034 0.039
Schistosoma mansoni hypothetical protein 0.0236 0.0829 0.0829
Onchocerca volvulus 0.0036 0.0094 0.1123
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0073 0.0231 0.0231
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0064 0.0064
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0032 0.0364
Echinococcus granulosus neuropeptide receptor A26 0.0476 0.1706 0.1706
Trypanosoma cruzi GUP1, putative 0.0236 0.0829 1
Trichomonas vaginalis conserved hypothetical protein 0.0236 0.0829 0.9867
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.0392 0.0392
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0236 0.0829 0.0829
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0036 0.0036
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0184 0.0184
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0148 0.0506 0.6282
Schistosoma mansoni rab6-interacting 0.002 0.0036 0.0036
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0034 0.039
Loa Loa (eye worm) MBOAT family protein 0.2742 1 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0036 0.0036
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0032 0.0382
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0015 0.0015
Echinococcus granulosus Aminotransferase class III 0.0021 0.0041 0.0041
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0236 0.0829 0.0829
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0094 0.0971
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0119 0.0119
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0094 0.0971
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0034 0.039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0127 0.0127
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.008 0.008
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0021 0.0041 0.0523
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0069 0.0069
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0021 0.0041 0.0523
Echinococcus granulosus sterol O acyltransferase 1 0.0236 0.0829 0.0829
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0055 0.0659
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0045 0.0045
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0094 0.0094
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0119 0.1271
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0055 0.049
Brugia malayi hypothetical protein 0.0016 0.0023 0.0023
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0021 0.0041 0.0041
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.049 0.049
Loa Loa (eye worm) hypothetical protein 0.0236 0.0829 0.0829
Schistosoma mansoni lipoxygenase 0.0117 0.0392 0.0392
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0119 0.1086
Loa Loa (eye worm) hypothetical protein 0.0236 0.0829 0.0829
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0073 0.0231 0.2657
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0036 0.0036
Plasmodium vivax ornithine aminotransferase, putative 0.0021 0.0041 0.011
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0036 0.0421
Schistosoma mansoni myst-related protein 0.001 0.0001 0.0001
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0073 0.0231 0.0231
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0106 0.1271
Brugia malayi Pre-SET motif family protein 0.0211 0.0734 0.0734
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0032 0.0032
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0184 0.2071
Schistosoma mansoni cytochrome P450 0.0014 0.0015 0.0015
Mycobacterium tuberculosis Conserved protein 0.0036 0.0094 0.101
Onchocerca volvulus 0.002 0.0036 0.0423
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0236 0.0829 0.0829
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0094 0.101
Schistosoma mansoni ap endonuclease 0.0019 0.0032 0.0032
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0047 0.0047
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0032 0.0032
Echinococcus multilocularis ornithine aminotransferase 0.0021 0.0041 0.0041
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0106 0.3695
Brugia malayi MBOAT family protein 0.0236 0.0829 0.0829
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0073 0.0231 1
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0236 0.0829 0.0829
Echinococcus multilocularis Aminotransferase class III 0.0021 0.0041 0.0041
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0147 0.1624
Loa Loa (eye worm) hypothetical protein 0.0036 0.0094 0.0094
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0034 0.039
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0236 0.0829 0.0829
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.008 0.008
Schistosoma mansoni polycystin 1-related 0.002 0.0036 0.0036
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0236 0.0829 0.0829
Onchocerca volvulus 0.0236 0.0829 0.9867
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0184 0.0184
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0094 0.1104
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0032 0.0032
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0032 0.0208
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0127 0.0127
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0127 0.0127
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0034 0.039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0127 0.0127
Echinococcus multilocularis muscleblind protein 1 0.0302 0.1068 0.1068
Trypanosoma brucei glycerol uptake protein, putative 0.0236 0.0829 1
Onchocerca volvulus 0.0085 0.0275 0.3277
Brugia malayi beta-lactamase family protein 0.0036 0.0094 0.0094
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0021 0.0041 0.0329
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0021 0.0041 1
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0147 0.0147
Echinococcus multilocularis cpg binding protein 0.009 0.0293 0.0293
Brugia malayi MBOAT family protein 0.0236 0.0829 0.0829
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.0797 1
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0236 0.0829 0.0829
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0055 0.049
Brugia malayi Hhat protein 0.0236 0.0829 0.0829
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0021 0.0041 0.0329
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0005 0.0005
Mycobacterium tuberculosis Probable aminotransferase 0.0148 0.0506 0.6282
Loa Loa (eye worm) hypothetical protein 0.0302 0.1068 0.1068
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.008 0.008
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.2742 1 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0073 0.0231 0.0231
Echinococcus granulosus zinc finger protein 0.2506 0.9135 0.9135
Echinococcus multilocularis ornithine aminotransferase 0.0021 0.0041 0.0041
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0055 0.0288
Entamoeba histolytica hypothetical protein 0.0071 0.0225 0.2707
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0127 0.0127
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0094 0.1104
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0094 0.1104
Brugia malayi MBOAT family protein 0.0236 0.0829 0.0829
Echinococcus granulosus tumor protein p63 0.0334 0.1188 0.1188
Schistosoma mansoni lipoxygenase 0.0082 0.0263 0.0263
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0034 0.039
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0094 0.0094
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0147 0.1738
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0184 0.3431
Plasmodium falciparum ornithine aminotransferase 0.0021 0.0041 0.0488
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0147 0.1624
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0236 0.0829 0.0829
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0034 0.039
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.0476 0.0476
Trypanosoma cruzi glycerol uptake protein, putative 0.0236 0.0829 1
Plasmodium vivax SET domain protein, putative 0.0032 0.008 0.0603
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0045 0.0045
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0184 0.3431
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0236 0.0829 0.0829
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0021 0.0041 0.0329
Schistosoma mansoni cpg binding protein 0.0085 0.0275 0.0275
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0021 0.0041 0.0329
Trichomonas vaginalis conserved hypothetical protein 0.0236 0.0829 0.9867
Brugia malayi hypothetical protein 0.0025 0.0055 0.0055
Leishmania major glycerol uptake protein, putative 0.0236 0.0829 1
Schistosoma mansoni rab6-interacting 0.002 0.0036 0.0036
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0049 0.0143 0.0143
Loa Loa (eye worm) hhat protein 0.0236 0.0829 0.0829
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0231 0.2741
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0055 0.049
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.049 0.049
Schistosoma mansoni hypothetical protein 0.0011 0.0005 0.0005
Mycobacterium ulcerans lipase LipD 0.0036 0.0094 0.1608
Trypanosoma cruzi glycerol uptake protein, putative 0.0236 0.0829 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0045 0.0045
Trichomonas vaginalis helicase, putative 0.0019 0.0034 0.039
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0147 0.0147
Loa Loa (eye worm) acetyltransferase 0.0144 0.049 0.049
Toxoplasma gondii exonuclease III APE 0.0019 0.0032 0.0208
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0036 0.0036
Onchocerca volvulus 0.0036 0.0094 0.1123
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0236 0.0829 0.0829
Mycobacterium leprae Probable lipase LipE 0.0036 0.0094 0.1608
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0094 0.101
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0021 0.0041 0.0316
Echinococcus multilocularis neuropeptide receptor A26 0.0476 0.1706 0.1706
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0236 0.0829 0.0829
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0147 0.1624
Brugia malayi Cytochrome P450 family protein 0.0023 0.0047 0.0047
Brugia malayi Muscleblind-like protein 0.0302 0.1068 0.1068
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0094 0.1608
Echinococcus granulosus o acyltransferase membrane bound domain 0.0236 0.0829 0.0829
Trichomonas vaginalis porcupine, putative 0.0236 0.0829 0.9867
Onchocerca volvulus 0.0032 0.008 0.0956
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0147 0.0147
Brugia malayi Doublecortin family protein 0.002 0.0036 0.0036
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0236 0.0829 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0147 0.1624
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0094 0.101
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.008 0.008
Leishmania major hypothetical protein, conserved 0.0236 0.0829 1
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0236 0.0829 0.0829
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0236 0.0829 0.0829
Mycobacterium ulcerans hypothetical protein 0.0148 0.0506 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0094 0.1104
Brugia malayi Cytochrome P450 family protein 0.0023 0.0047 0.0047
Entamoeba histolytica hypothetical protein 0.0236 0.0829 1
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0236 0.0829 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0055 0.049
Schistosoma mansoni hypothetical protein 0.1211 0.4398 0.4398
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0034 0.039
Trichomonas vaginalis transmembrane protein nessy, putative 0.0236 0.0829 0.9867
Echinococcus granulosus ubiquitin specific protease 41 0.0073 0.0231 0.0231
Echinococcus granulosus muscleblind protein 0.0302 0.1068 0.1068
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0184 0.2071
Toxoplasma gondii ABC1 family protein 0.0036 0.0094 0.0971
Schistosoma mansoni cpg binding protein 0.009 0.0293 0.0293
Mycobacterium tuberculosis Conserved protein 0.0036 0.0094 0.101
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0184 0.2155
Leishmania major cytochrome p450-like protein 0.0023 0.0047 0.0391
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0094 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0236 0.0829 0.9867
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0036
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0032 0.0344
Mycobacterium tuberculosis Conserved protein 0.0036 0.0094 0.101
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0147 0.1624
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0127 0.0127
Echinococcus granulosus RUN 0.002 0.0036 0.0036
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0147 0.1624
Echinococcus multilocularis neuropeptide s receptor 0.0476 0.1706 0.1706
Loa Loa (eye worm) hypothetical protein 0.0036 0.0094 0.0094
Echinococcus granulosus dnaJ subfamily B 0.1211 0.4398 0.4398
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0073 0.0231 0.2657
Toxoplasma gondii histone lysine methyltransferase SET1 0.0166 0.0571 0.6827
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0021 0.0041 0.0523
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0021 0.0041 0.0523
Onchocerca volvulus 0.002 0.0036 0.0423
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0047 0.0648
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0184 0.0184
Entamoeba histolytica hypothetical protein 0.0071 0.0225 0.2707
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0236 0.0829 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0073 0.0231 0.0231
Trichomonas vaginalis esterase, putative 0.0036 0.0094 0.1104
Echinococcus multilocularis dnaJ subfamily B 0.1211 0.4398 0.4398
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0147 0.1738
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0045 0.0045
Echinococcus granulosus cpg binding protein 0.009 0.0293 0.0293
Echinococcus multilocularis RUN 0.002 0.0036 0.0036
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0094 0.0094
Onchocerca volvulus 0.0239 0.084 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0094 0.0971
Schistosoma mansoni hypothetical protein 0.0071 0.0225 0.0225
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0236 0.0829 0.0829
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0034 0.039
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0036 0.0036
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0236 0.0829 1
Trypanosoma cruzi GUP1, putative 0.0236 0.0829 1
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0148 0.0506 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0013 0.0013 0.0013
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0021 0.0041 0.0523
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0032 0.0382
Echinococcus multilocularis zinc finger protein 0.2506 0.9135 0.9135
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0047 0.0391
Entamoeba histolytica hypothetical protein 0.0071 0.0225 0.2707
Loa Loa (eye worm) MBOAT family protein 0.0236 0.0829 0.0829
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.0734 0.0734
Schistosoma mansoni hypothetical protein 0.002 0.0036 0.0036
Loa Loa (eye worm) doublecortin family protein 0.002 0.0036 0.0036
Mycobacterium ulcerans beta-lactamase 0.0036 0.0094 0.1608
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0094 0.101
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0236 0.0829 0.0829
Trypanosoma brucei glycerol uptake protein, putative 0.0236 0.0829 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0032 0.0216
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0147 0.0147
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0236 0.0829 1
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0021 0.0041 0.5
Trypanosoma cruzi glycerol uptake protein, putative 0.0236 0.0829 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0034 0.039
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0073 0.0231 0.0231
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.008 0.0798
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0094 0.101
Loa Loa (eye worm) hypothetical protein 0.0036 0.0094 0.0094
Onchocerca volvulus 0.0049 0.0143 0.1703
Loa Loa (eye worm) hypothetical protein 0.0302 0.1068 0.1068
Brugia malayi beta-lactamase family protein 0.0036 0.0094 0.0094
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0127 0.0127
Brugia malayi diacylglycerol acyltransferase 0.0236 0.0829 0.0829
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.008 0.008
Toxoplasma gondii hypothetical protein 0.0236 0.0829 1
Entamoeba histolytica hypothetical protein, conserved 0.0236 0.0829 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0119 0.1396
Treponema pallidum alginate O-acetylation protein (algI) 0.0236 0.0829 1
Leishmania major glycerol uptake protein, putative 0.0236 0.0829 1
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0148 0.0506 1
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0094 0.1608
Leishmania major hypothetical protein, conserved 0.0025 0.0055 0.049
Echinococcus granulosus o acyltransferase membrane bound domain 0.0236 0.0829 0.0829
Loa Loa (eye worm) hhat protein 0.0236 0.0829 0.0829
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0182 0.0628 0.0628
Echinococcus multilocularis sterol O acyltransferase 1 0.0236 0.0829 0.0829
Leishmania major glycerol uptake protein, putative 0.0236 0.0829 1
Onchocerca volvulus 0.0036 0.0094 0.1123
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0094 0.0094
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0148 0.0506 0.602
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0034 0.039
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0032 0.0364
Loa Loa (eye worm) hypothetical protein 0.0036 0.0094 0.0094
Loa Loa (eye worm) CXXC zinc finger family protein 0.0085 0.0275 0.0275
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0047 0.0047
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0073 0.0231 0.2741
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0236 0.0829 0.0829
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0147 0.1624
Mycobacterium ulcerans L-lysine aminotransferase 0.0021 0.0041 0.0523
Loa Loa (eye worm) hypothetical protein 0.0025 0.0055 0.0055
Brugia malayi beta-lactamase 0.0036 0.0094 0.0094
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0034 0.039
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0063 0.0063
Mycobacterium ulcerans acetylornithine aminotransferase 0.0021 0.0041 0.0523
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0236 0.0829 1
Leishmania major hypothetical protein, conserved 0.0036 0.0094 0.0971
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0034 0.039
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0236 0.0829 0.0829
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0032 0.0208
Brugia malayi Pre-SET motif family protein 0.0032 0.008 0.008
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0119 0.1271
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0073 0.0231 0.2741
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0073 0.0231 0.2787
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0047 0.0047
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0094 0.0094
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0147 0.1738
Echinococcus multilocularis tumor protein p63 0.0334 0.1188 0.1188
Brugia malayi MBOAT family protein 0.0236 0.0829 0.0829
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0236 0.0829 0.0829
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.049 0.049
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0236 0.0829 0.0829
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0034 0.039
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0147 0.1624
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0154 0.0154
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0036 0.0041
Entamoeba histolytica vacuolar protein sorting 26 0.0236 0.0829 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0094 0.0094
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0094 0.0779
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0064 0.0064
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0047 0.0391
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0073 0.0231 0.0231
Brugia malayi hypothetical protein 0.0071 0.0225 0.0225
Brugia malayi Cytochrome P450 family protein 0.0014 0.0015 0.0015
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0225 0.0225
Trypanosoma brucei protein kinase, putative 0.005 0.0147 0.1624
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0094 0.101
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0055 0.0659
Brugia malayi hypothetical protein 0.002 0.0036 0.0036
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.008 0.008
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0073 0.0231 0.2657
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0236 0.0829 0.0829
Schistosoma mansoni zinc finger protein 0.2742 1 1
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0236 0.0829 0.0829
Loa Loa (eye worm) beta-lactamase 0.0036 0.0094 0.0094
Schistosoma mansoni loxhd1 0.002 0.0036 0.0036
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0005 0.0005
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.2742 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0045 0.0045
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0094 0.101
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0147 0.5784
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0147 0.1738
Loa Loa (eye worm) MBOAT family protein 0.0236 0.0829 0.0829
Echinococcus granulosus ornithine aminotransferase 0.0021 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0036
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0106 0.1271
Schistosoma mansoni sterol O-acyltransferase 1 0.0236 0.0829 0.0829
Echinococcus granulosus o acyltransferase membrane bound domain 0.0236 0.0829 0.0829
Loa Loa (eye worm) hypothetical protein 0.0036 0.0094 0.0094
Brugia malayi cytochrome P450 0.0014 0.0015 0.0015
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0127 0.0127
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0225 0.0225
Entamoeba histolytica hypothetical protein 0.0071 0.0225 0.2707
Echinococcus multilocularis muscleblind protein 0.0302 0.1068 0.1068
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0073 0.0231 0.0231

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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