Detailed information for compound 546544

Basic information

Technical information
  • TDR Targets ID: 546544
  • Name: 1-(dimethylamino)-4-methyl-6-oxo-piperidine-2 ,2,3,3-tetracarbonitrile
  • MW: 256.263 | Formula: C12H12N6O
  • H donors: 0 H acceptors: 5 LogP: -0.44 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1(C#N)N(N(C)C)C(=O)CC(C1(C#N)C#N)C
  • InChi: 1S/C12H12N6O/c1-9-4-10(19)18(17(2)3)12(7-15,8-16)11(9,5-13)6-14/h9H,4H2,1-3H3
  • InChiKey: YCKSWHYIGGXBDZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(dimethylamino)-4-methyl-6-oxopiperidine-2,2,3,3-tetracarbonitrile
  • 1-(dimethylamino)-6-keto-4-methyl-piperidine-2,2,3,3-tetracarbonitrile
  • 1-dimethylamino-4-methyl-6-oxopiperidine-2,2,3,3-tetracarbonitrile
  • 1-dimethylamino-4-methyl-6-oxo-piperidine-2,2,3,3-tetracarbonitrile
  • 1-dimethylamino-6-keto-4-methyl-piperidine-2,2,3,3-tetracarbonitrile
  • Piperidine-2,2,3,3-tetracarbonitrile, 1-(dimethylamino)-4-methyl-6-oxo-
  • A2020/0084756
  • NCI60_029288
  • 1-(Dimethylamino)-4-methyl-6-oxo-2,2,3,3-piperidinetetracarbonitrile
  • AIDS-148813
  • AIDS148813
  • NSC681850
  • TimTec1_003666

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0045 0.0815
Onchocerca volvulus 0.0024 0.0082 0.0318
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0024 0.0082 0.0079
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0989 0.7461 1
Echinococcus granulosus neuropeptide receptor 0.0024 0.0082 0.0079
Loa Loa (eye worm) hypothetical protein 0.1321 1 1
Giardia lamblia DINP protein human, muc B family 0.0019 0.0045 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0184 0.2819
Schistosoma mansoni retinoic acid receptor RXR 0.0016 0.0023 0.002
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0024 0.0082 0.0099
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0447 0.0588
Echinococcus granulosus RUN 0.0022 0.0065 0.0056
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0023 0.002
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0174 0.0203
Trypanosoma cruzi glycerol uptake protein, putative 0.0085 0.0552 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0162 0.0187
Brugia malayi GnHR receptor homolog 0.0024 0.0082 0.008
Schistosoma mansoni biogenic amine receptor 0.0024 0.0082 0.0099
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0023 0.0001
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0123 0.01
Trypanosoma cruzi GUP1, putative 0.0085 0.0552 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0024 0.0082 0.0079
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0023 0.002
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0727 0.546 0.545
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0057 0.0037
Trypanosoma cruzi glycerol uptake protein, putative 0.0085 0.0552 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0024 0.0082 0.0079
Loa Loa (eye worm) hhat protein 0.0085 0.0552 0.053
Brugia malayi nuclear hormone receptor 0.0016 0.0023 0.0001
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0045 0.001
Echinococcus multilocularis neuropeptide s receptor 0.0024 0.0082 0.0079
Brugia malayi Dopamine receptor 0.0024 0.0082 0.008
Onchocerca volvulus 0.0258 0.1872 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.0184 0.0236
Echinococcus multilocularis RUN 0.0022 0.0065 0.0056
Schistosoma mansoni growth hormone secretagogue receptor 0.0024 0.0082 0.0099
Trichomonas vaginalis transmembrane protein nessy, putative 0.0085 0.0552 0.1146
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0083 0.0359
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0086 0.0554 0.1067
Echinococcus granulosus neuropeptide FF receptor 2 0.0024 0.0082 0.0079
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0082 0.0079
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0065 0.0056
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0184 0.2819
Brugia malayi hypothetical protein 0.0025 0.009 0.009
Schistosoma mansoni rab6-interacting 0.0022 0.0065 0.0076
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.009 0.0419
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0447 0.091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.1281 0.1707
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0086 0.0554 0.4358
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0085 0.0552 0.0711
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.1281 0.1707
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0045 0.0029
Loa Loa (eye worm) MBOAT family protein 0.0085 0.0552 0.053
Echinococcus multilocularis ornithine aminotransferase 0.0086 0.0554 0.0714
Loa Loa (eye worm) beta-lactamase 0.0071 0.0447 0.0424
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0085 0.0552 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0057 0.0037
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.009 0.0962
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0184 0.2804
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0016 0.0023 0.002
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0184 0.3344
Treponema pallidum alginate O-acetylation protein (algI) 0.0085 0.0552 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0549 0.0707
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0184 0.2819
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0024 0.0082 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0023 0.0001
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.009 0.0968
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0045 0.009
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0082 0.0079
Schistosoma mansoni histamine h1 receptor 0.0024 0.0082 0.0099
Loa Loa (eye worm) MBOAT family protein 0.0085 0.0552 0.053
Brugia malayi hypothetical protein 0.0242 0.1746 0.2317
Echinococcus granulosus zinc finger protein 0.0904 0.681 0.9124
Brugia malayi Melatonin receptor type 1A 0.0024 0.0082 0.008
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0184 0.0323
Loa Loa (eye worm) hypothetical protein 0.0906 0.6822 0.6814
Brugia malayi diacylglycerol acyltransferase 0.0085 0.0552 0.0711
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0023 0.0001
Mycobacterium ulcerans acetylornithine aminotransferase 0.0086 0.0554 0.1152
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0024 0.0081 0.0078
Trypanosoma cruzi GUP1, putative 0.0085 0.0552 1
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0082 0.0079
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.004 0.0017
Loa Loa (eye worm) hypothetical protein 0.0085 0.0552 0.053
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0045 0.0049
Brugia malayi beta-lactamase family protein 0.0071 0.0447 0.057
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0024 0.0082 0.0079
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0447 0.091
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0184 0.2819
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0447 0.0569
Entamoeba histolytica hypothetical protein 0.0036 0.0174 0.2613
Schistosoma mansoni DNA polymerase eta 0.0019 0.0045 0.0049
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0024 0.0082 0.0079
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0082 0.0079
Leishmania major glycerol uptake protein, putative 0.0085 0.0552 1
Leishmania major DNA polymerase kappa, putative 0.0019 0.0045 0.009
Echinococcus granulosus 7TM GPCR rhodopsin 0.0024 0.0082 0.0079
Schistosoma mansoni alpha-1 adrenergic receptor 0.0024 0.0082 0.0099
Echinococcus multilocularis muscleblind protein 0.0906 0.6822 0.914
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0045 0.001
Schistosoma mansoni steroid hormone receptor ad4bp 0.0016 0.0023 0.002
Schistosoma mansoni cpg binding protein 0.0096 0.0631 0.0836
Brugia malayi hypothetical protein 0.0024 0.0082 0.008
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0082 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0162 0.0206
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0082 0.0099
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0045 0.001
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0086 0.0554 0.0733
Echinococcus granulosus orexin receptor type 2 0.0024 0.0082 0.0079
Onchocerca volvulus 0.0024 0.0082 0.0318
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0138 0.0154
Entamoeba histolytica hypothetical protein 0.0036 0.0174 0.2613
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0016 0.0023 0.0001
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0024 0.0082 0.0079
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0045 0.009
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0086 0.0554 0.1152
Onchocerca volvulus 0.0024 0.0082 0.0318
Schistosoma mansoni zinc finger protein 0.0989 0.7461 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Onchocerca volvulus 0.0024 0.0082 0.0318
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0045 0.009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0082 0.0099
Echinococcus multilocularis serotonin receptor 0.0024 0.0082 0.0079
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0065 0.0056
Echinococcus multilocularis dna polymerase eta 0.0019 0.0045 0.0029
Schistosoma mansoni neuropeptide receptor 0.0024 0.0082 0.0099
Onchocerca volvulus 0.0022 0.0065 0.0226
Trichomonas vaginalis set domain proteins, putative 0.0258 0.1872 0.4105
Schistosoma mansoni ap endonuclease 0.0018 0.004 0.0043
Trypanosoma brucei glycerol uptake protein, putative 0.0085 0.0552 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0083 0.0828
Schistosoma mansoni polycystin 1-related 0.0022 0.0065 0.0076
Mycobacterium tuberculosis Probable aminotransferase 0.0602 0.4503 1
Onchocerca volvulus 0.0071 0.0447 0.229
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0123 0.0135
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0447 0.0588
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0082 0.0079
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0082 0.0099
Schistosoma mansoni survival motor neuron protein 0.0049 0.0277 0.036
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Onchocerca volvulus 0.0024 0.0082 0.0318
Echinococcus granulosus o acyltransferase membrane bound domain 0.0085 0.0552 0.0711
Trichomonas vaginalis porcupine, putative 0.0085 0.0552 0.1146
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0447 0.091
Entamoeba histolytica hypothetical protein 0.0036 0.0174 0.2613
Entamoeba histolytica hypothetical protein 0.0024 0.0083 0.0828
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0085 0.0552 0.0711
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0065 0.0056
Brugia malayi Pre-SET motif family protein 0.0034 0.0162 0.0187
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Loa Loa (eye worm) hypothetical protein 0.0085 0.0549 0.0527
Brugia malayi hypothetical protein 0.0024 0.0082 0.008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0082 0.0099
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0065 0.0056
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0082 0.0079
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0174 0.0222
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0024 0.0082 0.0318
Echinococcus granulosus hypothetical protein 0.0024 0.0082 0.0079
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0193 0.1377 0.1836
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0045 0.0815
Brugia malayi hypothetical protein 0.0022 0.0065 0.0057
Leishmania major glycerol uptake protein, putative 0.0085 0.0552 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0447 0.057
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0184 0.1222
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0045 0.0029
Brugia malayi steroid hormone receptor 0.0016 0.0023 0.0001
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0024 0.0082 0.0059
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0045 0.0029
Brugia malayi putative neuropeptide receptor 0.0024 0.0082 0.008
Brugia malayi nuclear receptor NHR-88 0.0016 0.0023 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0552 0.1146
Onchocerca volvulus 0.0024 0.0082 0.0318
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0057 0.0037
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0602 0.4503 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0552 0.053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.1281 0.1707
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0082 0.0099
Brugia malayi MBOAT family protein 0.0989 0.7461 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0082 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0016 0.0023 0.0001
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0085 0.0552 0.0729
Brugia malayi MBOAT family protein 0.0085 0.0552 0.0711
Brugia malayi hypothetical protein 0.0024 0.0082 0.008
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0447 0.091
Toxoplasma gondii histone lysine methyltransferase SET1 0.0173 0.122 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0082 0.0079
Echinococcus granulosus somatostatin receptor 0.0024 0.0082 0.0079
Echinococcus granulosus 7tm_1 domain containing protein 0.0024 0.0082 0.0079
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0024 0.0082 0.0079
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Entamoeba histolytica vacuolar protein sorting 26 0.0085 0.0552 1
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0447 0.7944
Onchocerca volvulus 0.0024 0.0082 0.0318
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0045 0.001
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0045 0.0815
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0082 0.0079
Brugia malayi hypothetical protein 0.0024 0.0082 0.008
Onchocerca volvulus 0.0024 0.0082 0.0318
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0023 0.0001
Schistosoma mansoni sterol O-acyltransferase 1 0.0085 0.0552 0.0729
Brugia malayi Tachykinin-like peptides receptor 99D 0.0024 0.0082 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0057 0.0037
Schistosoma mansoni amine GPCR 0.0024 0.0082 0.0099
Onchocerca volvulus 0.0024 0.0082 0.0318
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0057 0.0037
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0082 0.0079
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0162 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0057 0.0037
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0082 0.0079
Brugia malayi AKH receptor 0.0024 0.0082 0.008
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0082 0.0079
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0082 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0045 0.0815
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0057 0.0037
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0082 0.0059
Echinococcus multilocularis dro:myosuppressin receptor 0.0024 0.0082 0.0079
Onchocerca volvulus 0.0024 0.0082 0.0318
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0083 0.0824
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0082 0.0099
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0082 0.0099
Echinococcus granulosus allatostatin A receptor 0.0024 0.0082 0.0079
Brugia malayi MBOAT family protein 0.0085 0.0552 0.0711
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Schistosoma mansoni hypothetical protein 0.0022 0.0065 0.0076
Brugia malayi hypothetical protein 0.0024 0.0082 0.008
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.004 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0045 0.0815
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.004 0.0023
Loa Loa (eye worm) hypothetical protein 0.0071 0.0447 0.0424
Brugia malayi beta-lactamase family protein 0.0071 0.0447 0.057
Onchocerca volvulus 0.0071 0.0447 0.229
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0045 0.0815
Loa Loa (eye worm) hypothetical protein 0.0022 0.0065 0.0042
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0065 0.0476
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0798 0.6003 0.8039
Echinococcus multilocularis sex peptide receptor 0.0024 0.0082 0.0079
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0045 0.009
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0016 0.0023 0.0001
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0024 0.0082 0.0079
Schistosoma mansoni loxhd1 0.0022 0.0065 0.0076
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0184 0.0217
Mycobacterium ulcerans beta-lactamase 0.0071 0.0447 0.091
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0083 0.0824
Echinococcus granulosus neuropeptide s receptor 0.0024 0.0082 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0057 0.0037
Leishmania major hypothetical protein, conserved 0.0025 0.009 0.0968
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0082 0.0079
Brugia malayi Pre-SET motif family protein 0.0227 0.1635 0.2167
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0082 0.0099
Loa Loa (eye worm) hypothetical protein 0.0019 0.0045 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0045 0.0815
Echinococcus granulosus G protein coupled receptor 139 0.0024 0.0082 0.0079
Echinococcus granulosus tachykinin peptides receptor 99D 0.0024 0.0082 0.0079
Brugia malayi Doublecortin family protein 0.0022 0.0065 0.0057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0082 0.0079
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0082 0.0079
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.004 0.0023
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0085 0.0552 0.0711
Schistosoma mansoni opsin-like receptor 0.0024 0.0082 0.0099
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0082 0.0079
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0082 0.0099
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0045 0.009
Echinococcus granulosus g protein coupled receptor 0.0024 0.0082 0.0079
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0083 0.0359
Onchocerca volvulus 0.0024 0.0082 0.0318
Schistosoma mansoni biogenic amine receptor 0.0024 0.0082 0.0099
Onchocerca volvulus 0.0024 0.0082 0.0318
Brugia malayi Steroid receptor seven-up type 2 0.0016 0.0023 0.0001
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0803 0.0781
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0162 0.103
Schistosoma mansoni lipoxygenase 0.0022 0.0065 0.0076
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0016 0.0023 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0552 0.1146
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0024 0.0082 0.008
Loa Loa (eye worm) hypothetical protein 0.0034 0.0162 0.0139
Brugia malayi ecdysteroid receptor 0.0016 0.0023 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0447 0.091
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0081 0.0097
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0024 0.0082 0.0059
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.009 0.0968
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0121 0.0132
Loa Loa (eye worm) hypothetical protein 0.0025 0.009 0.0067
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0447 0.091
Schistosoma mansoni opsin-like receptor 0.0024 0.0082 0.0099
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0447 0.091
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0082 0.0079
Schistosoma mansoni hypothetical protein 0.0024 0.0082 0.0099
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Brugia malayi Dopamine receptor protein 1 0.0024 0.0082 0.008
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0082 0.0099
Mycobacterium ulcerans lipase LipD 0.0071 0.0447 0.091
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0082 0.0079
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0085 0.0552 0.9945
Mycobacterium tuberculosis Conserved protein 0.0071 0.0447 0.091
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0083 0.0824
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0085 0.0552 0.053
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0184 0.0323
Brugia malayi MBOAT family protein 0.0085 0.0552 0.0711
Brugia malayi hypothetical protein 0.0024 0.0082 0.008
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0024 0.0082 0.0079
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0083 0.1498
Schistosoma mansoni inositol monophosphatase 0.0037 0.0184 0.0236
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0602 0.4503 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0082 0.0079
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0082 0.0079
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0085 0.0552 0.0729
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0057 0.0037
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0181 0.1281 0.1691
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0045 0.0049
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.009 0.0962
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0085 0.0552 0.0711
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0162 0.0206
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0085 0.0552 0.0711
Echinococcus granulosus muscleblind protein 0.0906 0.6822 0.914
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0082 0.0099
Mycobacterium ulcerans L-lysine aminotransferase 0.0086 0.0554 0.1152
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0057 0.0037
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0082 0.0079
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Trichomonas vaginalis helicase, putative 0.0021 0.0057 0.0037
Loa Loa (eye worm) TYRA-2 protein 0.0024 0.0082 0.0059
Loa Loa (eye worm) hypothetical protein 0.0022 0.0065 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0082 0.0099
Echinococcus granulosus sex peptide receptor 0.0024 0.0082 0.0079
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0083 0.0095
Onchocerca volvulus 0.0085 0.0552 0.2859
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0045 0.0022
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0045 0.003
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0045 0.0815
Echinococcus multilocularis Aminotransferase class III 0.0086 0.0554 0.0714
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0045 0.0815
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0085 0.0552 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0447 0.0424
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0016 0.0023 0.0001
Brugia malayi putative neuropeptide receptor NPR1 0.0024 0.0082 0.008
Brugia malayi beta-lactamase 0.0071 0.0447 0.057
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Brugia malayi Dopamine receptor protein 2 0.0024 0.0082 0.008
Onchocerca volvulus 0.0024 0.0082 0.0318
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0024 0.0082 0.0099
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0057 0.0037
Onchocerca volvulus Neuropeptide F receptor homolog 0.0024 0.0082 0.0318
Onchocerca volvulus 0.0085 0.0549 0.2845
Echinococcus granulosus o acyltransferase membrane bound domain 0.0085 0.0552 0.0711
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0082 0.0079
Brugia malayi G protein-coupled receptor F59B2.13 0.0024 0.0082 0.008
Trypanosoma brucei unspecified product 0.0019 0.0045 0.0815
Loa Loa (eye worm) hypothetical protein 0.0071 0.0447 0.0424
Leishmania major glycerol uptake protein, putative 0.0085 0.0552 1
Brugia malayi hypothetical protein 0.0024 0.0082 0.008
Schistosoma mansoni amine GPCR 0.0024 0.0082 0.0099
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0447 0.7944
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0082 0.0079
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Echinococcus granulosus g-protein coupled receptor 0.0024 0.0082 0.0079
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0082 0.0079
Brugia malayi CXXC zinc finger family protein 0.0091 0.0592 0.0766
Schistosoma mansoni amine GPCR 0.0024 0.0082 0.0099
Echinococcus granulosus ornithine aminotransferase 0.0086 0.0554 0.0714
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0184 0.0217
Onchocerca volvulus 0.0024 0.0082 0.0318
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0057 0.0037
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0085 0.0552 0.0729
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Schistosoma mansoni amine GPCR 0.0024 0.0082 0.0099
Plasmodium falciparum ornithine aminotransferase 0.0086 0.0554 1
Schistosoma mansoni hypothetical protein 0.0036 0.0174 0.0222
Entamoeba histolytica hypothetical protein 0.0036 0.0174 0.2613
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Echinococcus granulosus o acyltransferase membrane bound domain 0.0085 0.0552 0.0711
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0162 0.0206
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0016 0.0023 0.002
Echinococcus granulosus mixed lineage leukemia protein mll 0.0024 0.0081 0.0078
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Loa Loa (eye worm) hypothetical protein 0.0242 0.1746 0.1727
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0447 0.091
Brugia malayi hypothetical protein 0.0024 0.0082 0.008
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0085 0.0552 0.9945
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0447 0.7901
Schistosoma mansoni cpg binding protein 0.0096 0.0631 0.0836
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0045 0.0815
Echinococcus granulosus neuropeptide receptor 0.0024 0.0082 0.0079
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0181 0.1281 0.1691
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0086 0.0554 0.1152
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0024 0.0082 0.0059
Schistosoma mansoni lipoxygenase 0.006 0.0361 0.0473
Onchocerca volvulus 0.0071 0.0447 0.229
Brugia malayi G protein-coupled receptor 0.0024 0.0082 0.008
Echinococcus multilocularis G protein coupled receptor 139 0.0024 0.0082 0.0079
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0045 0.0815
Brugia malayi G-protein coupled receptor 0.0024 0.0082 0.008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0024 0.0082 0.0079
Loa Loa (eye worm) hypothetical protein 0.0071 0.0447 0.0424
Echinococcus granulosus serotonin receptor 0.0024 0.0082 0.0079
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0181 0.1281 0.1691
Echinococcus granulosus sterol O acyltransferase 1 0.0085 0.0552 0.0711
Schistosoma mansoni myosin xvIII 0.0024 0.0082 0.0099
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0447 0.8094
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0086 0.0554 0.1152
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0024 0.0082 0.008
Schistosoma mansoni cpg binding protein 0.0091 0.0592 0.0783
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0057 0.0037
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0082 0.0079
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0082 0.0079
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0045 0.009
Mycobacterium ulcerans hypothetical protein 0.0071 0.0447 0.091
Echinococcus granulosus dna polymerase eta 0.0019 0.0045 0.0029
Echinococcus granulosus neuropeptide receptor A26 0.0024 0.0082 0.0079
Trypanosoma cruzi glycerol uptake protein, putative 0.0085 0.0552 1
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0086 0.0554 0.1152
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0024 0.0082 0.0079
Mycobacterium ulcerans hypothetical protein 0.0602 0.4503 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0045 0.009
Onchocerca volvulus 0.0034 0.0162 0.075
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0184 0.0323
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0162 0.0206
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0081 0.0078
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0082 0.0079
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0082 0.0079
Brugia malayi Muscleblind-like protein 0.0906 0.6822 0.914
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0086 0.0554 1
Schistosoma mansoni rab6-interacting 0.0022 0.0065 0.0076
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Entamoeba histolytica hypothetical protein 0.0085 0.0552 1
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0085 0.0552 0.0711
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0023 0.002
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0082 0.0079
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0065 0.0056
Trichomonas vaginalis esterase, putative 0.0071 0.0447 0.091
Plasmodium vivax ornithine aminotransferase, putative 0.0086 0.0554 1
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0086 0.0554 0.1152
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0082 0.0099
Mycobacterium leprae Probable lipase LipE 0.0071 0.0447 0.0823
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0184 0.0323
Toxoplasma gondii ABC1 family protein 0.0071 0.0447 0.3443
Echinococcus granulosus dnaJ subfamily B 0.0849 0.6392 0.8563
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0016 0.0023 0.0001
Brugia malayi MBOAT family protein 0.0085 0.0552 0.0711
Brugia malayi neuropeptide F receptor 0.0024 0.0082 0.008
Brugia malayi RE15519p 0.0024 0.0082 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0552 0.1146
Brugia malayi G-protein coupled receptor 0.0024 0.0082 0.008
Onchocerca volvulus 0.0091 0.0592 0.3077
Echinococcus multilocularis orexin receptor type 2 0.0024 0.0082 0.0079
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0057 0.0037
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0024 0.0082 0.0079
Entamoeba histolytica hypothetical protein, conserved 0.0085 0.0552 1
Onchocerca volvulus 0.0049 0.0277 0.1371
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0057 0.0037
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0065 0.0476
Brugia malayi photoreceptor-specific nuclear receptor 0.0016 0.0023 0.0001
Echinococcus granulosus Aminotransferase class III 0.0086 0.0554 0.0714
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0277 0.0342
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0085 0.0552 0.0729
Loa Loa (eye worm) hypothetical protein 0.0906 0.6822 0.6814
Schistosoma mansoni RAR-like nuclear receptor 0.0016 0.0023 0.002
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0803 0.0781
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0082 0.0079
Echinococcus multilocularis ornithine aminotransferase 0.0086 0.0554 0.0714
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0045 0.009
Echinococcus granulosus g protein coupled receptor 0.0024 0.0082 0.0079
Leishmania major hypothetical protein, conserved 0.0085 0.0552 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0024 0.0082 0.008
Brugia malayi hypothetical protein 0.0036 0.0174 0.0204
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Schistosoma mansoni ap endonuclease 0.0018 0.004 0.0043
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0082 0.0079
Brugia malayi Inositol-1 0.0037 0.0184 0.0218
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0086 0.0554 0.1067
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.006 0.0361 0.0455
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0086 0.0554 0.0715
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0085 0.0552 0.0711
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0082 0.0079
Schistosoma mansoni hypothetical protein 0.0849 0.6392 0.8566
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0083 0.0828
Leishmania major glycerol uptake protein, putative 0.0085 0.0552 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0024 0.0082 0.0079
Loa Loa (eye worm) hypothetical protein 0.0085 0.0552 0.053
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0082 0.0079
Echinococcus granulosus arachidonate 5 lipoxygenase 0.006 0.0361 0.0455
Brugia malayi MH2 domain containing protein 0.0118 0.0803 0.1049
Schistosoma mansoni biogenic amine receptor 0.0024 0.0082 0.0099
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0447 0.091
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.009 0.0962
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0086 0.0554 0.1152
Loa Loa (eye worm) hhat protein 0.0085 0.0552 0.053
Brugia malayi Hhat protein 0.0085 0.0552 0.0711
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0082 0.0099
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0082 0.0079
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0024 0.0082 0.0099
Echinococcus multilocularis muscleblind protein 1 0.0906 0.6822 0.914
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0227 0.1635 0.1615
Brugia malayi hypothetical protein 0.0024 0.0082 0.008
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0447 0.091
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0602 0.4503 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0549 0.0707
Schistosoma mansoni hypothetical protein 0.0049 0.0277 0.036
Echinococcus multilocularis dnaJ subfamily B 0.0849 0.6392 0.8563
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0082 0.0079
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0024 0.0082 0.008
Brugia malayi follicle stimulating hormone receptor 0.0727 0.546 0.731
Loa Loa (eye worm) hypothetical protein 0.0085 0.0552 0.053
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0447 0.091
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0181 0.1281 0.1692
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0016 0.0023 0.0001
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0989 0.7461 1
Schistosoma mansoni hypothetical protein 0.0024 0.0082 0.0099
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0057 0.0037
Echinococcus multilocularis somatostatin receptor 0.0024 0.0082 0.0079
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0155 0.0163
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0085 0.0552 0.4335
Schistosoma mansoni neuropeptide receptor 0.0024 0.0082 0.0099
Echinococcus granulosus dro:myosuppressin receptor 0.0024 0.0082 0.0079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0082 0.0079
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0023 0.002
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0082 0.0079
Toxoplasma gondii hypothetical protein 0.0085 0.0552 0.4335
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0023 0.0001
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0086 0.0554 0.1152
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0083 0.0095
Loa Loa (eye worm) hypothetical protein 0.0071 0.0447 0.0424
Brugia malayi Serotonin receptor 0.0024 0.0082 0.008
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0081 0.0078
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0065 0.0042
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0181 0.1281 0.1691
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.009 0.1628
Leishmania major hypothetical protein, conserved 0.0071 0.0447 0.7944
Echinococcus granulosus fmrfamide receptor 0.0024 0.0082 0.0079
Schistosoma mansoni neuropeptide receptor 0.0024 0.0082 0.0099
Leishmania major glycerol uptake protein, putative 0.0085 0.0552 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0155 0.0256
Schistosoma mansoni hypothetical protein 0.0085 0.0552 0.0729
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0024 0.0082 0.0099
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0045 0.001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0174 0.0203
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0016 0.0023 0.002
Schistosoma mansoni neuropeptide f receptor 76f 0.0024 0.0082 0.0099
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0082 0.0059
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.1746 0.2317
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0085 0.0552 0.0711
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0457 0.3391 0.7509
Loa Loa (eye worm) hypothetical protein 0.0071 0.0447 0.0424
Brugia malayi hypothetical protein 0.0024 0.0082 0.008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0082 0.0079
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0085 0.0552 0.0711
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0085 0.0552 0.0711
Mycobacterium tuberculosis Conserved protein 0.0071 0.0447 0.091
Brugia malayi ORL1-like opioid receptor 0.0024 0.0082 0.008
Brugia malayi larval opioid receptor 0.0024 0.0082 0.008
Echinococcus granulosus dna polymerase kappa 0.0019 0.0045 0.0029
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Echinococcus granulosus peptide allatostatin:somatostatin 0.0024 0.0082 0.0079
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0083 0.0095
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0082 0.0079
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0162 0.0187
Echinococcus multilocularis cpg binding protein 0.0096 0.0631 0.0818
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0447 0.091
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0085 0.0552 0.053
Loa Loa (eye worm) inositol-1 0.0037 0.0184 0.0162
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.004 0.0731
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0045 0.0815
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0045 0.003
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0024 0.0082 0.0099
Brugia malayi sulfakinin receptor protein 0.0024 0.0082 0.008
Loa Loa (eye worm) CXXC zinc finger family protein 0.0091 0.0592 0.057
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0086 0.0554 0.1067
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.1746 0.2317
Schistosoma mansoni neuropeptide receptor 0.0024 0.0082 0.0099
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0085 0.0552 0.0729
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0024 0.0082 0.0059
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0082 0.0079
Plasmodium vivax SET domain protein, putative 0.0034 0.0162 0.2363
Echinococcus multilocularis g-protein coupled receptor 0.0024 0.0082 0.0079
Echinococcus granulosus g protein coupled receptor 0.0024 0.0082 0.0079
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0085 0.0552 1
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0082 0.0099
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0045 0.0815
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0082 0.0079
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0024 0.0082 0.008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Loa Loa (eye worm) MBOAT family protein 0.0989 0.7461 0.7455
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0016 0.0023 0.002
Loa Loa (eye worm) hypothetical protein 0.0071 0.0447 0.0424
Brugia malayi Serotonin receptor 0.0024 0.0082 0.008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Brugia malayi hypothetical protein 0.0022 0.0065 0.0057
Loa Loa (eye worm) melatonin receptor type 1A 0.0024 0.0082 0.0059
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0549 0.0708
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0023 0.0001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0181 0.1281 0.1261
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0082 0.0079
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0085 0.0552 0.0729
Onchocerca volvulus 0.0024 0.0082 0.0318
Echinococcus multilocularis neuropeptide receptor A26 0.0024 0.0082 0.0079
Mycobacterium tuberculosis Conserved protein 0.0071 0.0447 0.091
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0023 0.0001
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0024 0.0082 0.0099
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0086 0.0554 0.1152
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0024 0.0082 0.0099
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0082 0.0079
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0045 0.001
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0447 0.0569
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0082 0.0079
Brugia malayi neuropeptide F receptor 0.0024 0.0082 0.008
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0447 0.0823
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0016 0.0023 0.0001
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0549 0.0726
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Trypanosoma brucei glycerol uptake protein, putative 0.0085 0.0552 1
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0086 0.0554 1
Echinococcus multilocularis serotonin receptor 0.0024 0.0082 0.0079
Echinococcus multilocularis zinc finger protein 0.0904 0.681 0.9124
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0447 0.091
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0065 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Schistosoma mansoni hypothetical protein 0.0024 0.0082 0.0099
Schistosoma mansoni opsin-like receptor 0.0024 0.0082 0.0099
Schistosoma mansoni adenoreceptor 0.0024 0.0082 0.0099
Schistosoma mansoni amine GPCR 0.0024 0.0082 0.0099
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0123 0.0135
Onchocerca volvulus 0.0024 0.0082 0.0318
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0085 0.0552 0.0711
Echinococcus multilocularis allatostatin A receptor 0.0024 0.0082 0.0079
Onchocerca volvulus 0.0024 0.0082 0.0318
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0082 0.0099
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0059
Echinococcus granulosus cpg binding protein 0.0096 0.0631 0.0818
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0057 0.0037
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0602 0.4503 1
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0082 0.0059
Schistosoma mansoni hypothetical protein 0.0024 0.0082 0.0099
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0447 0.091
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0082 0.0099
Onchocerca volvulus 0.0022 0.0065 0.0226
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0085 0.0552 0.4335
Echinococcus multilocularis sterol O acyltransferase 1 0.0085 0.0552 0.0711
Schistosoma mansoni coup transcription factor 0.0016 0.0023 0.002
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0045 0.0815
Echinococcus multilocularis neuropeptide FF receptor 2 0.0024 0.0082 0.0079

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -6.185 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.119 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.912 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.813 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.771 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.743 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.741 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.699 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.678 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.659 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.617 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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