Detailed information for compound 561361

Basic information

Technical information
  • TDR Targets ID: 561361
  • Name: 5,5-dimethyl-2-phenyl-morpholine hydrochlorid e
  • MW: 227.73 | Formula: C12H18ClNO
  • H donors: 1 H acceptors: 0 LogP: 2.37 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1(C)NCC(OC1)c1ccccc1.Cl
  • InChi: 1S/C12H17NO.ClH/c1-12(2)9-14-11(8-13-12)10-6-4-3-5-7-10;/h3-7,11,13H,8-9H2,1-2H3;1H
  • InChiKey: ITCSSRXQXNXMCG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5,5-dimethyl-2-phenylmorpholine hydrochloride
  • 2-phenyl-5,5-dimethyltetrahydro-1,4-oxazine
  • 42013-48-9
  • 36981-93-8
  • 2-Phenyl-5,5-dimethyl-tetrahydro-1,4-oxazine hydrochloride
  • Morpholine, 5,5-dimethyl-2-phenyl-, hydrochloride
  • Phenyl dimethyltetrahydrooxazine
  • 2-Phenyl-5,5-dimethyl-tetrahydro-1,4-oxazin-hydrochlorid [German]

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0126 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0126 0.012 0.012
Echinococcus multilocularis Niemann Pick C1 protein 0.0155 0.0156 0.0155
Mycobacterium ulcerans hypothetical protein 0.0076 0.0058 0.3414
Schistosoma mansoni nuclear hormone receptor 0.0054 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0071 0.0053 0.0053
Echinococcus granulosus mothers against decapentaplegic 5 0.0043 0.0019 0.0018
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0013 0.0377
Loa Loa (eye worm) hypothetical protein 0.3472 0.4228 0.4228
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0054 0.0032 0.0031
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0115 0.0107 0.0106
Loa Loa (eye worm) ICD-1 protein 0.0039 0.0013 0.0013
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0246 0.0267 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0222 0.0238 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0054 0.0032 0.0031
Echinococcus granulosus transcription factor eb 0.0576 0.0673 0.0673
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0067 0.0047 0.0047
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.0146 0.4163
Echinococcus multilocularis smad 0.0043 0.0019 0.0018
Toxoplasma gondii isocitrate dehydrogenase 0.0067 0.0047 0.6372
Loa Loa (eye worm) MH2 domain-containing protein 0.0637 0.0748 0.0748
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0031 0.1079
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.02 0.0211 0.7864
Brugia malayi Smad1 0.0043 0.0019 0.0018
Loa Loa (eye worm) hypothetical protein 0.0057 0.0035 0.0035
Onchocerca volvulus Huntingtin homolog 0.0126 0.012 0.7058
Plasmodium falciparum glutathione reductase 0.0088 0.0073 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0054 0.0032 0.0031
Leishmania major hypothetical protein, conserved 0.0038 0.0013 0.029
Echinococcus multilocularis thyroid hormone receptor alpha 0.0054 0.0032 0.0031
Echinococcus granulosus survival motor neuron protein 1 0.0523 0.0608 0.0608
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0014 0.012
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0054 0.0032 0.0031
Echinococcus granulosus tumor protein p63 0.0348 0.0392 0.0392
Echinococcus multilocularis protein patched 0.0047 0.0022 0.0022
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0006 0.0006
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0006 0.0006
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0088 0.0073 0.2656
Echinococcus granulosus Smad4 0.0043 0.0019 0.0018
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0028 0.0027
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0031 0.1079
Echinococcus granulosus muscleblind protein 0.0798 0.0945 0.0944
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0057 0.0035 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.0058 0.2171
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0014 0.0684
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0014 0.0325
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0031 0.0817
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0013 0.0609
Schistosoma mansoni microtubule-associated protein tau 0.2208 0.2676 0.2676
Toxoplasma gondii thioredoxin reductase 0.0088 0.0073 1
Schistosoma mansoni thyroid hormone receptor 0.0054 0.0032 0.0031
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0054 0.0032 0.0032
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0014 0.5618
Brugia malayi MH1 domain containing protein 0.0043 0.0019 0.0018
Echinococcus multilocularis bifunctional protein NCOAT 0.8172 1 1
Schistosoma mansoni patched 1 0.0047 0.0022 0.0022
Echinococcus multilocularis microtubule associated protein 2 0.2208 0.2676 0.2676
Onchocerca volvulus Huntingtin homolog 0.0126 0.012 0.7058
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0019 0.0476
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.8172 1 1
Loa Loa (eye worm) hypothetical protein 0.0573 0.0669 0.0669
Leishmania major mitochondrial DNA polymerase beta 0.0311 0.0347 1
Schistosoma mansoni hypothetical protein 0.0033 0.0006 0.0006
Schistosoma mansoni Hyaluronidase 0.8172 1 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0013 0.0377
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.02 0.0211 0.7864
Loa Loa (eye worm) hypothetical protein 0.0038 0.0013 0.0013
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0067 0.0047 0.13
Loa Loa (eye worm) hypothetical protein 0.0523 0.0608 0.0608
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0054 0.0032 0.0031
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0003 0.0002
Mycobacterium tuberculosis Conserved protein 0.0038 0.0013 0.0377
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.0347 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.02 0.0211 0.7864
Echinococcus granulosus bifunctional protein NCOAT 0.8172 1 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0107 0.0096 0.0096
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0054 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0057 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0013 0.5051
Loa Loa (eye worm) hypothetical protein 0.0038 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0045 0.002 0.002
Echinococcus multilocularis geminin 0.0535 0.0623 0.0622
Echinococcus multilocularis sterol regulatory element binding protein 0.0047 0.0022 0.0022
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0109 0.0099 0.5842
Schistosoma mansoni survival motor neuron protein 0.0107 0.0096 0.0096
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0067 0.0047 0.13
Loa Loa (eye worm) hypothetical protein 0.0076 0.0058 0.0058
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0054 0.0032 0.0031
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0076 0.0058 0.2113
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0013 0.5051
Echinococcus granulosus ecdysone induced protein 78C 0.0054 0.0032 0.0031
Plasmodium falciparum basic transcription factor 3b, putative 0.0039 0.0013 0.1432
Leishmania major basic transcription factor 3a, putative 0.0039 0.0013 0.0292
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0019 0.0476
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0043 0.0019 0.0018
Echinococcus granulosus smad 0.0043 0.0019 0.0018
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0054 0.0032 0.0031
Brugia malayi steroid hormone receptor 0.0054 0.0032 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0054 0.0032 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0054 0.0032 0.0031
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0047 0.0022 0.0022
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0013 0.0609
Brugia malayi Inositol-1 0.0039 0.0014 0.0013
Echinococcus granulosus expressed conserved protein 0.0102 0.009 0.009
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0013 0.0012
Onchocerca volvulus Protein ultraspiracle homolog 0.0054 0.0032 0.1826
Schistosoma mansoni hypothetical protein 0.0033 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0109 0.0099 0.0099
Brugia malayi HSF-type DNA-binding domain containing protein 0.0109 0.0099 0.0099
Onchocerca volvulus 0.0167 0.017 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0054 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0038 0.0013 0.0013
Echinococcus granulosus geminin 0.0535 0.0623 0.0622
Entamoeba histolytica heat shock transcription factor, putative 0.0109 0.0099 0.9241
Toxoplasma gondii isocitrate dehydrogenase 0.0067 0.0047 0.6372
Loa Loa (eye worm) isocitrate dehydrogenase 0.0067 0.0047 0.0047
Trypanosoma cruzi trypanothione reductase, putative 0.0088 0.0073 0.2041
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0013 0.0377
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0006 0.0006
Echinococcus multilocularis transcription factor btf3 0.0039 0.0013 0.0012
Brugia malayi beta-lactamase family protein 0.0038 0.0013 0.0012
Onchocerca volvulus 0.0076 0.0058 0.3415
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0013 0.0012
Brugia malayi nuclear hormone receptor 0.0054 0.0032 0.0031
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0067 0.0047 0.6372
Trichomonas vaginalis esterase, putative 0.0038 0.0013 0.5005
Toxoplasma gondii NAC domain-containing protein 0.0039 0.0013 0.1432
Brugia malayi hypothetical protein 0.0115 0.0107 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0054 0.0032 0.0031
Echinococcus multilocularis FTZ F1 alpha 0.0054 0.0032 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0022 1
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0013 0.0292
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0067 0.0047 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0054 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0033 0.0006 0.0006
Toxoplasma gondii ABC1 family protein 0.0038 0.0013 0.142
Brugia malayi Niemann-Pick C1 protein precursor 0.0109 0.0099 0.0098
Schistosoma mansoni inositol monophosphatase 0.0039 0.0014 0.0013
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0105 0.0094 0.0094
Schistosoma mansoni hypothetical protein 0.0107 0.0096 0.0096
Echinococcus multilocularis protein dispatched 1 0.0053 0.0031 0.003
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0054 0.0032 0.0031
Mycobacterium tuberculosis Conserved protein 0.0038 0.0013 0.0377
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0054 0.0032 0.0032
Schistosoma mansoni smad 0.0043 0.0019 0.0018
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0058 0.1623
Echinococcus multilocularis muscleblind protein 0.0798 0.0945 0.0944
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0013 0.5005
Plasmodium vivax basic transcription factor 3b, putative 0.0039 0.0013 0.1432
Echinococcus multilocularis isocitrate dehydrogenase 0.0067 0.0047 0.0047
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0003 0.0002
Echinococcus granulosus sterol regulatory element binding protein 0.0047 0.0022 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0013 0.029
Brugia malayi Nuclear hormone receptor-like 1 0.0054 0.0032 0.0031
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0067 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0033 0.0006 0.0006
Entamoeba histolytica hypothetical protein 0.0115 0.0107 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.0058 0.2171
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0013 0.142
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.0347 1
Echinococcus granulosus GPCR family 2 0.0033 0.0006 0.0006
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.0094 0.0093
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0014 0.0013
Loa Loa (eye worm) glutathione reductase 0.0088 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0109 0.0099 0.0099
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0067 0.0047 0.1693
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0013 0.0168
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.0094 0.0093
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0009 0.0231
Loa Loa (eye worm) Smad1 0.0043 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0045 0.002 0.002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0006 0.0006
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0013 0.0012
Mycobacterium tuberculosis Probable oxidoreductase 0.0222 0.0238 0.8899
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.0166 0.6189
Entamoeba histolytica hypothetical protein 0.0115 0.0107 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0054 0.0032 0.0031
Echinococcus granulosus transcription factor btf3 0.0039 0.0013 0.0012
Echinococcus multilocularis tumor protein p63 0.0348 0.0392 0.0392
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0031 0.1079
Plasmodium vivax thioredoxin reductase, putative 0.0088 0.0073 1
Schistosoma mansoni hypothetical protein 0.0071 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0045 0.002 0.002
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0054 0.0032 0.0031
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0001 0.0001
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0054 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0167 0.017 0.017
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0054 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0054 0.0032 0.0032
Loa Loa (eye worm) transcription factor SMAD2 0.0637 0.0748 0.0748
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2601 0.316 0.3159
Loa Loa (eye worm) hypothetical protein 0.0038 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0054 0.0032 0.0031
Brugia malayi photoreceptor-specific nuclear receptor 0.0054 0.0032 0.0031
Schistosoma mansoni transcription factor btf3 0.0039 0.0013 0.0012
Entamoeba histolytica hypothetical protein 0.0115 0.0107 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0067 0.0047 0.13
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0003 0.0002
Loa Loa (eye worm) MH1 domain-containing protein 0.0043 0.0019 0.0019
Brugia malayi MH2 domain containing protein 0.0043 0.0019 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0054 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0076 0.0058 0.0058
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0058 0.0058
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.0003 0.5
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0019 0.0476
Onchocerca volvulus Bile acid receptor homolog 0.0054 0.0032 0.1826
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0013 0.5051
Echinococcus multilocularis transcription factor eb 0.0576 0.0673 0.0673
Brugia malayi CHE-14 protein 0.0047 0.0022 0.0022
Loa Loa (eye worm) hyaluronidase 0.8172 1 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0067 0.0047 0.6372
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0115 0.0107 0.0106
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0013 0.0012
Mycobacterium tuberculosis Putative ferredoxin reductase 0.02 0.0211 0.7864
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0573 0.0669 0.0669
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0054 0.0032 0.0031
Echinococcus multilocularis Smad4 0.0043 0.0019 0.0018
Brugia malayi nuclear receptor NHR-88 0.0054 0.0032 0.0031
Schistosoma mansoni niemann-pick C1 (NPC1) 0.011 0.0101 0.01
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0014 0.0013
Trypanosoma brucei transcription factor BTF3, putative 0.0039 0.0013 0.0292
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0222 0.0238 0.8899
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0013 0.0292
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0076 0.0058 0.3414
Entamoeba histolytica heat shock transcription factor, putative 0.0109 0.0099 0.9241
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0058 0.3414
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0006 0.0006
Onchocerca volvulus 0.0054 0.0032 0.1826
Brugia malayi MH1 domain containing protein 0.0043 0.0019 0.0018
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0076 0.0058 0.3414
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0006 0.0006
Entamoeba histolytica acyl-CoA synthetase, putative 0.0076 0.0058 0.4873
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0013 0.5005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0054 0.0032 0.0031
Echinococcus granulosus FTZ F1 alpha 0.0054 0.0032 0.0031
Schistosoma mansoni coup transcription factor 0.0054 0.0032 0.0031
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0054 0.0032 0.0031
Entamoeba histolytica hypothetical protein 0.0115 0.0107 1
Entamoeba histolytica heat shock transcription factor, putative 0.0109 0.0099 0.9241
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0067 0.0047 0.13
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0058 0.3414
Loa Loa (eye worm) hypothetical protein 0.0038 0.0013 0.0013
Mycobacterium ulcerans hypothetical protein 0.0038 0.0013 0.0609
Schistosoma mansoni Smad4 0.0043 0.0019 0.0018
Schistosoma mansoni steroid hormone receptor ad4bp 0.0054 0.0032 0.0031
Schistosoma mansoni smad1 5 8 and 0.0043 0.0019 0.0018
Loa Loa (eye worm) MH2 domain-containing protein 0.0043 0.0019 0.0019
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0076 0.0058 0.3414
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0076 0.0058 0.2113
Brugia malayi Isocitrate dehydrogenase 0.0067 0.0047 0.0047
Onchocerca volvulus 0.0038 0.0013 0.0701
Brugia malayi ecdysteroid receptor 0.0054 0.0032 0.0031
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0014 0.5618
Plasmodium falciparum acyl-CoA synthetase 0.0057 0.0035 0.4602
Echinococcus multilocularis mothers against decapentaplegic 5 0.0043 0.0019 0.0018
Onchocerca volvulus 0.0107 0.0096 0.5658
Echinococcus granulosus Protein patched homolog 1 0.0047 0.0022 0.0022
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0013 0.029
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.0146 0.4163
Echinococcus multilocularis Niemann Pick C1 protein 0.0109 0.0099 0.0098
Loa Loa (eye worm) beta-lactamase 0.0038 0.0013 0.0013
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0057 0.0035 0.1975
Loa Loa (eye worm) hypothetical protein 0.0054 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0126 0.012 0.012
Echinococcus granulosus thioredoxin glutathione reductase 0.0088 0.0073 0.0073
Mycobacterium ulcerans lipase LipD 0.0038 0.0013 0.0609
Onchocerca volvulus 0.0038 0.0013 0.0701
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0013 0.5005
Brugia malayi MH2 domain containing protein 0.0637 0.0748 0.0748
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0054 0.0032 0.0031
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0058 0.1623
Echinococcus granulosus microtubule associated protein 2 0.2208 0.2676 0.2676
Schistosoma mansoni RAR-like nuclear receptor 0.0054 0.0032 0.0031
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0014 0.1593
Entamoeba histolytica acyl-coA synthetase, putative 0.0076 0.0058 0.4873
Mycobacterium tuberculosis Probable reductase 0.02 0.0211 0.7864
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0576 0.0673 0.0673
Schistosoma mansoni smad1 5 8 and 0.0043 0.0019 0.0018
Onchocerca volvulus 0.0038 0.0013 0.0701
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0054 0.0032 0.0031
Schistosoma mansoni thyroid hormone receptor 0.0054 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0054 0.0032 0.0032
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.0094 0.0094
Brugia malayi MH2 domain containing protein 0.0043 0.0019 0.0018
Mycobacterium tuberculosis Conserved protein 0.0038 0.0013 0.0377
Plasmodium vivax acyl-CoA synthetase, putative 0.0057 0.0035 0.4602
Loa Loa (eye worm) hypothetical protein 0.0057 0.0035 0.0035
Brugia malayi hypothetical protein 0.0167 0.017 0.017
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0054 0.0032 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0054 0.0032 0.0031
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0013 0.5005
Schistosoma mansoni hypothetical protein 0.0535 0.0623 0.0622
Loa Loa (eye worm) hypothetical protein 0.0057 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0029 0.0001 0.0001
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0222 0.0238 0.8899
Loa Loa (eye worm) hypothetical protein 0.0054 0.0032 0.0032
Brugia malayi Steroid receptor seven-up type 2 0.0054 0.0032 0.0031
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0014 0.5618
Loa Loa (eye worm) hypothetical protein 0.0798 0.0945 0.0945
Entamoeba histolytica acyl-CoA synthetase, putative 0.0076 0.0058 0.4873
Mycobacterium ulcerans beta-lactamase 0.0038 0.0013 0.0609
Loa Loa (eye worm) hypothetical protein 0.0076 0.0058 0.0058
Echinococcus granulosus TGF beta signal transducer SmadC 0.0043 0.0019 0.0018
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0013 0.0377
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0013 0.029
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0014 0.0325
Loa Loa (eye worm) hypothetical protein 0.0057 0.0035 0.0035
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0067 0.0047 0.0047
Echinococcus multilocularis thioredoxin glutathione reductase 0.0088 0.0073 0.0073
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0311 0.0347 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0076 0.0058 0.3414
Schistosoma mansoni hypothetical protein 0.0045 0.002 0.002
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0798 0.0945 0.0945
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0067 0.0047 0.13
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0054 0.0032 0.1826
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0058 0.1623
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0054 0.0032 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0054 0.0032 0.0032
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0054 0.0032 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0054 0.0032 0.0031
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0014 0.0325
Echinococcus granulosus Niemann Pick C1 protein 0.0155 0.0156 0.0155
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0043 0.0019 0.0018
Onchocerca volvulus 0.0051 0.0028 0.1602
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0001 0.0001
Brugia malayi beta-lactamase 0.0038 0.0013 0.0012
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0014 0.0325
Schistosoma mansoni hypothetical protein 0.0033 0.0006 0.0006
Brugia malayi glutathione reductase 0.0088 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0054 0.0032 0.0032
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.0146 0.4163
Brugia malayi beta-NAC-like protein 0.0039 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0047 0.0022 0.0022
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0013 0.0377
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0054 0.0032 0.0032
Echinococcus multilocularis ecdysone induced protein 78C 0.0054 0.0032 0.0031
Echinococcus multilocularis muscleblind protein 1 0.0798 0.0945 0.0944
Echinococcus multilocularis GPCR, family 2 0.0033 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0535 0.0623 0.0622
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0014 1
Echinococcus multilocularis expressed conserved protein 0.0102 0.009 0.009
Brugia malayi Muscleblind-like protein 0.0798 0.0945 0.0944
Loa Loa (eye worm) inositol-1 0.0039 0.0014 0.0014
Plasmodium vivax glutathione reductase, putative 0.0088 0.0073 1
Brugia malayi hypothetical protein 0.0523 0.0608 0.0608
Leishmania major trypanothione reductase 0.0088 0.0073 0.2041
Brugia malayi Thioredoxin reductase 0.0088 0.0073 0.0073
Schistosoma mansoni inositol monophosphatase 0.0039 0.0014 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0054 0.0032 0.0032
Echinococcus multilocularis survival motor neuron protein 1 0.0523 0.0608 0.0608
Loa Loa (eye worm) steroid hormone receptor 0.0054 0.0032 0.0032
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.02 0.0211 0.8806
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0058 0.3414
Loa Loa (eye worm) hypothetical protein 0.0054 0.0032 0.0032
Toxoplasma gondii hypothetical protein 0.005 0.0027 0.3455
Schistosoma mansoni transcription factor LCR-F1 0.0115 0.0107 0.0106
Mycobacterium leprae Probable lipase LipE 0.0038 0.0013 0.0168
Mycobacterium ulcerans hypothetical protein 0.0164 0.0166 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0031 0.1079
Loa Loa (eye worm) thioredoxin reductase 0.0088 0.0073 0.0073
Treponema pallidum NADH oxidase 0.003 0.0003 0.5
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0109 0.0099 0.914
Loa Loa (eye worm) hypothetical protein 0.0051 0.0028 0.0028
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0053 0.0053
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0054 0.0032 0.0032
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0013 0.0012
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0019 0.0476
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0057 0.0035 0.1223
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0013 0.0377
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0013 0.5005
Loa Loa (eye worm) hypothetical protein 0.0057 0.0035 0.0035
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0067 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0038 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0054 0.0032 0.0031
Schistosoma mansoni hypothetical protein 0.0115 0.0107 0.0106
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0054 0.0032 0.0031
Mycobacterium tuberculosis Probable dehydrogenase 0.02 0.0211 0.7864
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0054 0.0032 0.0032
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0054 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0054 0.0032 0.0032
Echinococcus granulosus Niemann Pick C1 protein 0.0109 0.0099 0.0098
Brugia malayi isocitrate dehydrogenase 0.0067 0.0047 0.0047
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0067 0.0047 0.0047
Brugia malayi beta-lactamase family protein 0.0038 0.0013 0.0012
Schistosoma mansoni retinoic acid receptor RXR 0.0054 0.0032 0.0031
Plasmodium falciparum thioredoxin reductase 0.0088 0.0073 1
Schistosoma mansoni smad1 5 8 and 0.0043 0.0019 0.0018
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0013 0.0377
Trypanosoma brucei trypanothione reductase 0.0088 0.0073 0.2041

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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