Detailed information for compound 573588

Basic information

Technical information
  • TDR Targets ID: 573588
  • Name: sodium 2-(11-oxo-6H-benzo[c][2]benzothiepin-3 -yl)acetate
  • MW: 307.319 | Formula: C16H12NaO3S
  • H donors: 0 H acceptors: 3 LogP: 3.55 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-]C(=O)Cc1ccc2c(c1)SCc1c(C2=O)cccc1.[NaH+]
  • InChi: 1S/C16H12O3S.Na/c17-15(18)8-10-5-6-13-14(7-10)20-9-11-3-1-2-4-12(11)16(13)19;/h1-7H,8-9H2,(H,17,18);/q;+1/p-1
  • InChiKey: JSBMKFUICOYQJG-UHFFFAOYSA-M  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • sodium 2-(11-oxo-6H-benzo[c][2]benzothiepin-3-yl)ethanoate
  • sodium 2-(11-keto-6H-benzo[c][2]benzothiepin-3-yl)acetate
  • 61220-69-7
  • 77625-78-6
  • Dibenzo(b,e)thiepin-3-acetic acid, 6,11-dihydro-11-oxo-, sodium salt

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable reductase 0.0104 0.1687 0.6614
Echinococcus granulosus cpg binding protein 0.0034 0.0343 0.0375
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.1687 0.6614
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0075 0.1119 0.1728
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1513 0.1879
Echinococcus granulosus mitogen activated protein kinase 0.0106 0.1712 0.1872
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.1513 0.1513
Echinococcus multilocularis neuropeptide s receptor 0.0493 0.9144 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0797 0.0872
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0928 0.5424
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0662 0.0724
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0862 0.0943
Echinococcus granulosus RUN 0.0021 0.009 0.0098
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.009 0.099
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.1712 0.1525
Brugia malayi mbt repeat family protein 0.0051 0.0662 0.0662
Brugia malayi CXXC zinc finger family protein 0.0031 0.0274 0.0274
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0907 0.0991
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.1687 0.6614
Plasmodium falciparum glutathione reductase 0.0046 0.0564 1
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0662 0.0822
Schistosoma mansoni lipoxygenase 0.0021 0.009 0.0111
Echinococcus granulosus muscleblind protein 0.0159 0.2742 0.2998
Echinococcus granulosus Aminotransferase class III 0.0021 0.0087 0.0096
Brugia malayi mbt repeat family protein 0.0051 0.0662 0.0662
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0075 0.1119 0.0919
Loa Loa (eye worm) hypothetical protein 0.0045 0.054 0.054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.008 0.1223 0.1519
Plasmodium falciparum ornithine aminotransferase 0.0021 0.0087 0.155
Trichomonas vaginalis glucosylceramidase, putative 0.0372 0.6818 0.6746
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.054 0.0327
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.054 0.3154
Echinococcus multilocularis Aminotransferase class III 0.0021 0.0087 0.0096
Trypanosoma brucei glycosyl hydrolase-like protein 0.0028 0.022 0.1284
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0337 0.614 0.614
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.1712 0.1525
Mycobacterium tuberculosis Probable aminotransferase 0.0147 0.2506 1
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.6454 0.6374
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.1687 0.6614
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0662 0.0724
Schistosoma mansoni hypothetical protein 0.0436 0.8052 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0797 0.0797
Loa Loa (eye worm) hypothetical protein 0.0028 0.022 0.022
Schistosoma mansoni hypothetical protein 0.0164 0.2829 0.3514
Plasmodium vivax SET domain protein, putative 0.0064 0.0907 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0862 0.0943
Echinococcus multilocularis caspase 3 0.0073 0.109 0.1191
Loa Loa (eye worm) doublecortin family protein 0.0021 0.009 0.009
Plasmodium vivax glutathione reductase, putative 0.0046 0.0564 0.6216
Treponema pallidum fructose-bisphosphate aldolase 0.0299 0.5421 0.5
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0564 0.1969
Brugia malayi jmjC domain containing protein 0.0065 0.0931 0.0931
Echinococcus multilocularis muscleblind protein 0.0159 0.2742 0.2998
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0564 0.0616
Brugia malayi Doublecortin family protein 0.0021 0.009 0.009
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0928 0.1153
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0797 0.0872
Loa Loa (eye worm) hypothetical protein 0.0037 0.0398 0.0398
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.6454 0.6374
Schistosoma mansoni caspase-3 (C14 family) 0.0118 0.1943 0.2413
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0003 0.0003
Brugia malayi glutathione reductase 0.0046 0.0564 0.0564
Brugia malayi Thioredoxin reductase 0.0046 0.0564 0.0564
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.054 0.0327
Echinococcus multilocularis RUN 0.0021 0.009 0.0098
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.1513 0.1655
Onchocerca volvulus Cell death protein 3 homolog 0.0086 0.1335 0.1355
Schistosoma mansoni rab6-interacting 0.0021 0.009 0.0111
Echinococcus multilocularis apoptotic protease activating factor 1 0.0041 0.0481 0.0526
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.6454 0.6374
Echinococcus multilocularis caspase 2 0.0086 0.1335 0.146
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0928 0.1695
Brugia malayi Muscleblind-like protein 0.0159 0.2742 0.2742
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.5421 0.5319
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.2488 0.9926
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.1712 0.1525
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.1119 0.6534
Loa Loa (eye worm) hypothetical protein 0.0039 0.0442 0.0442
Echinococcus multilocularis neuropeptide receptor A26 0.0493 0.9144 1
Plasmodium falciparum metacaspase 1 0.0045 0.054 0.9582
Brugia malayi hypothetical protein 0.0041 0.0481 0.0481
Trichomonas vaginalis glucosylceramidase, putative 0.0538 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0662 0.0662
Brugia malayi Pre-SET motif family protein 0.044 0.8116 0.8116
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0201 0.3531 0.3861
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0907 0.1126
Trypanosoma brucei trypanothione reductase 0.0046 0.0564 0.3292
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0118 0.1943 0.2125
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0353 0.0386
Echinococcus multilocularis neutral alpha glucosidase AB 0.0075 0.1119 0.1223
Leishmania major metacaspase, putative 0.0045 0.054 0.3154
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0106 0.1712 1
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.6454 0.6374
Brugia malayi glutaminase DH11.1 0.028 0.505 0.505
Echinococcus multilocularis geminin 0.0164 0.2829 0.3094
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.009 0.0098
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0069 0.0075
Trichomonas vaginalis glucosylceramidase, putative 0.0372 0.6818 0.6746
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0928 0.1015
Loa Loa (eye worm) hypothetical protein 0.0058 0.0797 0.0797
Trypanosoma brucei protein kinase, putative 0.0106 0.1712 1
Trichomonas vaginalis set domain proteins, putative 0.05 0.9279 0.9262
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.6454 0.6374
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0021 0.0087 0.0087
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0564 0.0616
Trichomonas vaginalis glucosylceramidase, putative 0.0538 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.008 0.1223 0.1337
Schistosoma mansoni lipoxygenase 0.0059 0.0816 0.1013
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.054 0.0327
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0564 0.6216
Loa Loa (eye worm) MBCTL1 0.0058 0.0797 0.0797
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0147 0.2506 1
Trichomonas vaginalis glutaminase, putative 0.028 0.505 0.4939
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.1513 0.1655
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0059 0.0816 0.0892
Loa Loa (eye worm) hypothetical protein 0.0159 0.2742 0.2742
Schistosoma mansoni alpha-glucosidase 0.029 0.5241 0.6509
Leishmania major alpha glucosidase II subunit, putative 0.0075 0.1119 0.6534
Loa Loa (eye worm) hypothetical protein 0.0021 0.009 0.009
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0797 0.0872
Onchocerca volvulus Glucosylceramidase homolog 0.0353 0.6454 0.6926
Schistosoma mansoni hypothetical protein 0.0021 0.009 0.0111
Trypanosoma cruzi metacaspase, putative 0.0045 0.054 0.3154
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.054 0.0327
Schistosoma mansoni loxhd1 0.0021 0.009 0.0111
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.1513 0.1513
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0827 0.0905
Schistosoma mansoni cpg binding protein 0.0034 0.0343 0.0426
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.5421 0.5319
Echinococcus multilocularis lysosomal alpha glucosidase 0.0337 0.614 0.6714
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.054 0.0327
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.191 0.7537
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.054 0.0327
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.009 0.1593
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0353 0.0386
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0928 0.3477
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.1119 0.6534
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.1687 0.6614
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.1712 0.1525
Schistosoma mansoni hypothetical protein 0.002 0.0069 0.0086
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0106 0.1712 0.1712
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0538 1 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0016 0.0003 0.0003
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.2488 0.4837
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0147 0.2506 0.4873
Loa Loa (eye worm) hypothetical protein 0.0159 0.2742 0.2742
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.054 0.0327
Onchocerca volvulus 0.05 0.9279 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0075 0.1119 0.1119
Brugia malayi hypothetical protein 0.0021 0.009 0.009
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.1687 0.6614
Echinococcus multilocularis zinc finger protein 0.0021 0.0083 0.0091
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0862 0.1071
Loa Loa (eye worm) hypothetical protein 0.0086 0.1335 0.1335
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.044 0.8116 0.8116
Echinococcus granulosus mitogen activated protein kinase 3 0.0106 0.1712 0.1872
Trypanosoma cruzi metacaspase 5, putative 0.0045 0.054 0.3154
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0106 0.1712 1
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0928 0.1153
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.009 0.0098
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.022 0.1284
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.5421 1
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.009 0.0098
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0138 0.0151
Plasmodium vivax hypothetical protein, conserved 0.0045 0.054 0.5956
Loa Loa (eye worm) hypothetical protein 0.0021 0.009 0.009
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0003 0.0003
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0014 0.0014
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.191 0.7537
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0977 0.1213
Schistosoma mansoni caspase-7 (C14 family) 0.0118 0.1943 0.2413
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0201 0.3531 0.3861
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0021 0.0087 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0493 0.9144 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0337 0.614 0.6714
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.6454 0.6374
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0045 0.054 0.0671
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.054 0.0327
Onchocerca volvulus 0.0051 0.0662 0.0623
Schistosoma mansoni hypothetical protein 0.0041 0.0481 0.0598
Echinococcus granulosus lysosomal alpha glucosidase 0.0337 0.614 0.6714
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0021 0.0087 0.0108
Trypanosoma brucei glucosidase, putative 0.0075 0.1119 0.6534
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0662 0.0662
Trichomonas vaginalis glucosylceramidase, putative 0.0538 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.054 0.0327
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.022 0.1284
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.054 0.0327
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.1712 0.2126
Plasmodium vivax metacaspase 1, putative 0.0045 0.054 0.5956
Brugia malayi PHD-finger family protein 0.0026 0.0182 0.0182
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.054 0.3154
Echinococcus granulosus neutral alpha glucosidase AB 0.0075 0.1119 0.1223
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.1119 0.0919
Echinococcus granulosus zinc finger protein 0.0021 0.0083 0.0091
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.191 0.7537
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0075 0.1119 0.0919
Brugia malayi Glycosyl hydrolases family 31 protein 0.0337 0.614 0.614
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.022 0.022
Loa Loa (eye worm) glutathione reductase 0.0046 0.0564 0.0564
Schistosoma mansoni hypothetical protein 0.0164 0.2829 0.3514
Loa Loa (eye worm) glutaminase 2 0.028 0.505 0.505
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0059 0.0816 0.0892
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.1119 0.0919
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0862 0.0943
Echinococcus multilocularis mitogen activated protein kinase 0.0106 0.1712 0.1872
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.1513 0.1655
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.5421 0.5319
Echinococcus multilocularis caspase 0.0118 0.1943 0.2125
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0564 0.0564
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.054 0.0327
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.009 0.0098
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0021 0.0087 0.5
Echinococcus granulosus dnaJ subfamily B 0.0436 0.8052 0.8806
Schistosoma mansoni hypothetical protein 0.0309 0.5617 0.6976
Trypanosoma cruzi metacaspase, putative 0.0045 0.054 0.3154
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.054 0.3154
Trypanosoma brucei metacaspase MCA2 0.0045 0.054 0.3154
Echinococcus granulosus apoptotic protease activating factor 1 0.0041 0.0481 0.0526
Loa Loa (eye worm) hypothetical protein 0.008 0.1223 0.1223
Loa Loa (eye worm) glutaminase 0.028 0.505 0.505
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0028 0.022 0.0142
Mycobacterium ulcerans glutaminase 0.028 0.505 1
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0021 0.0087 0.051
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0016 0.0003 0.0003
Echinococcus multilocularis mitogen activated protein kinase 3 0.0106 0.1712 0.1872
Brugia malayi Cell death protein 3 precursor 0.0086 0.1335 0.1335
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.1119 0.0919
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0106 0.1712 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0106 0.1712 1
Schistosoma mansoni rab6-interacting 0.0021 0.009 0.0111
Leishmania major glycosyl hydrolase-like protein 0.0028 0.022 0.1284
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.191 0.7537
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0797 0.0872
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0931 0.0931
Echinococcus multilocularis cpg binding protein 0.0034 0.0343 0.0375
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.6454 0.6374
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1513 0.1879
Echinococcus multilocularis dnaJ subfamily B 0.0436 0.8052 0.8806
Echinococcus multilocularis muscleblind protein 1 0.0159 0.2742 0.2998
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.008 0.1223 0.1519
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0827 0.0905
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1513 0.1879
Onchocerca volvulus 0.0195 0.3419 0.3623
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0662 0.0623
Echinococcus granulosus geminin 0.0164 0.2829 0.3094
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.1119 0.0919
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.054 0.0327
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0662 0.0822
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0931 0.1156
Schistosoma mansoni zinc finger protein 0.0021 0.0083 0.0103
Echinococcus granulosus caspase 2 0.0086 0.1335 0.146
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.5421 0.5319
Echinococcus granulosus caspase 3 0.0073 0.109 0.1191
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.008 0.1223 0.1337
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.009 0.0098
Onchocerca volvulus 0.0031 0.0274 0.02
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0931 0.1018
Schistosoma mansoni alpha glucosidase 0.0075 0.1119 0.1389
Loa Loa (eye worm) hypothetical protein 0.0043 0.0511 0.0511
Trypanosoma brucei metacaspase MCA3 0.0045 0.054 0.3154
Trypanosoma brucei metacaspase 0.0045 0.054 0.3154
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0849 0.0929
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.5421 0.5319
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.2488 0.9926
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0907 0.1126
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0662 0.0724
Schistosoma mansoni bromodomain containing protein 0.0063 0.0894 0.111
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0106 0.1712 1
Echinococcus multilocularis ornithine aminotransferase 0.0021 0.0087 0.0096
Loa Loa (eye worm) hypothetical protein 0.008 0.1218 0.1218
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.054 0.0327
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0045 0.054 0.054
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0075 0.1119 0.1728
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0069 0.0069
Brugia malayi Bromodomain containing protein 0.0074 0.1111 0.1111
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.1513 0.1655
Echinococcus multilocularis ornithine aminotransferase 0.0021 0.0087 0.0096
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.008 0.1218 0.192
Schistosoma mansoni caspase-7 (C14 family) 0.0086 0.1335 0.1658
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0075 0.1119 0.1119
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0888 0.5186
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.1687 0.6614
Echinococcus granulosus neuropeptide s receptor 0.0493 0.9144 1
Onchocerca volvulus 0.0041 0.0481 0.0426
Loa Loa (eye worm) hypothetical protein 0.0041 0.0481 0.0481
Echinococcus multilocularis caspase 8 0.0045 0.054 0.059
Brugia malayi hypothetical protein 0.0021 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0068 0.0998 0.0998
Plasmodium falciparum thioredoxin reductase 0.0046 0.0564 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0274 0.0274
Trypanosoma brucei metacaspase 5, putative 0.0045 0.054 0.3154
Schistosoma mansoni alpha-glucosidase 0.029 0.5241 0.6509
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0662 0.0724
Brugia malayi Bromodomain containing protein 0.0037 0.0397 0.0397
Trichomonas vaginalis maltase-glucoamylase, putative 0.0075 0.1119 0.0919
Brugia malayi MAP kinase sur-1 0.0106 0.1712 0.1712
Echinococcus granulosus ornithine aminotransferase 0.0021 0.0087 0.0096
Plasmodium falciparum metacaspase-like protein 0.0045 0.054 0.9582
Trichomonas vaginalis glucosylceramidase, putative 0.0538 1 1
Plasmodium vivax ornithine aminotransferase, putative 0.0021 0.0087 0.0964
Mycobacterium ulcerans hypothetical protein 0.0147 0.2506 0.4873
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.054 0.0327
Echinococcus granulosus caspase 0.0118 0.1943 0.2125
Schistosoma mansoni cpg binding protein 0.0031 0.0274 0.034
Brugia malayi Pre-SET motif family protein 0.0064 0.0907 0.0907
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.054 0.0327
Giardia lamblia Fructose-bisphosphate aldolase 0.0299 0.5421 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0138 0.0151
Trypanosoma brucei Metacaspase-4 0.0045 0.054 0.3154
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0118 0.1943 0.2125
Brugia malayi jmjC domain containing protein 0.0061 0.0862 0.0862
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.1119 0.0919
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0138 0.0172
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0928 0.1695
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0106 0.1712 1
Onchocerca volvulus 0.0064 0.0907 0.0889
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0147 0.2506 1
Toxoplasma gondii thioredoxin reductase 0.0046 0.0564 0.3292
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0907 0.5296
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.008 0.1218 0.192
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.5421 0.5319
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.5421 0.5319
Trichomonas vaginalis glucosylceramidase, putative 0.0538 1 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0069 0.0075
Trypanosoma cruzi metacaspase 5, putative 0.0045 0.054 0.3154
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0564 0.3292
Schistosoma mansoni glutaminase 0.028 0.505 0.6272
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0106 0.1712 1
Trichomonas vaginalis glucosylceramidase, putative 0.0538 1 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0928 0.1015
Trichomonas vaginalis sucrase-isomaltase, putative 0.0075 0.1119 0.0919
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0147 0.2506 0.2338
Leishmania major trypanothione reductase 0.0046 0.0564 0.3292
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0106 0.1712 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.5421 0.5319
Echinococcus granulosus caspase 8 0.0045 0.054 0.059
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.5421 1
Trypanosoma cruzi metacaspase, putative 0.0045 0.054 0.3154
Trypanosoma cruzi metacaspase, putative 0.0045 0.054 0.3154
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0928 0.1695
Schistosoma mansoni polycystin 1-related 0.0021 0.009 0.0111
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0931 0.1156
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0662 0.0822
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0797 0.099
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.009 0.0098
Schistosoma mansoni cpg binding protein 0.0034 0.0343 0.0426
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0075 0.1119 0.6534
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0928 0.5424

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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