Detailed information for compound 573733

Basic information

Technical information
  • TDR Targets ID: 573733
  • Name: 2-[(4-aminophenyl)methyl]butanedioic acid
  • MW: 223.225 | Formula: C11H13NO4
  • H donors: 3 H acceptors: 4 LogP: 0.53 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(Cc1ccc(cc1)N)CC(=O)O
  • InChi: 1S/C11H13NO4/c12-9-3-1-7(2-4-9)5-8(11(15)16)6-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)(H,15,16)
  • InChiKey: HWEYHPQQWPDLAY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-aminobenzyl)succinic acid
  • 4-aminobenzylsuccinic acid
  • 61445-53-2
  • Butanedioic acid, ((4-aminophenyl)methyl)-
  • EINECS 262-800-8

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0245 0.0734
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0245 0.0245
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0245 0.052
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0314 0.4438 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0612 0.0612
Brugia malayi beta-lactamase family protein 0.0036 0.0243 0.0727
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0612 0.138
Schistosoma mansoni bromodomain containing protein 0.0064 0.0674 0.0674
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0621 0.0621
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.008 0.008
Schistosoma mansoni hypothetical protein 0.0044 0.0368 0.0368
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0612 0.0879
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0612 0.0612
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0243 0.0497
Leishmania major importin beta-1 subunit, putative 0.0024 0.0069 0.008
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0651 0.0651
Brugia malayi jmjC domain containing protein 0.0025 0.008 0.024
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0243 0.0514
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0243 0.0243
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0036 0.008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0388 0.0388
Giardia lamblia PHD finger protein 15 0.0029 0.0141 0.0261
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0069 0.0083
Leishmania major mitochondrial DNA polymerase beta 0.0299 0.4211 1
Brugia malayi beta-lactamase 0.0036 0.0243 0.0727
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0036 0.0079
Echinococcus multilocularis importin subunit beta 1 0.003 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0045 0.038 0.0845
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0153 0.2008 0.2008
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0014 0.003
Schistosoma mansoni alpha glucosidase 0.0036 0.0245 0.0245
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0314 0.4438 1
Toxoplasma gondii ABC1 family protein 0.0036 0.0243 0.3599
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0025 0.008 0.0774
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0245 0.3638
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0621 0.0621
Brugia malayi Muscleblind-like protein 0.0148 0.1934 0.5791
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0651 0.0651
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.4066 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0125 0.0125
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.029 0.4066 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0179
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0036 0.0036
Entamoeba histolytica hypothetical protein 0.0037 0.0265 0.0569
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0245 0.052
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0245 0.0245
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0069 0.0083
Loa Loa (eye worm) hypothetical protein 0.0148 0.1934 0.4309
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0245 0.052
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0242 0.0242
Echinococcus multilocularis zinc finger protein 0.0021 0.0022 0.0022
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.3137 0.6899
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0242 0.0242
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0245 0.052
Echinococcus granulosus alkaline phosphatase 0.0161 0.2132 0.2132
Entamoeba histolytica hypothetical protein 0.0037 0.0265 0.0569
Echinococcus granulosus peregrin 0.0031 0.0176 0.0176
Trichomonas vaginalis phospholipase A-2-activating protein, putative 0.0024 0.0068 0.008
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0245 0.052
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0243 0.0243
Leishmania major hypothetical protein, conserved 0.0025 0.008 0.0107
Schistosoma mansoni jumonji/arid domain-containing protein 0.0097 0.1163 0.1163
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.4066 1
Brugia malayi WD domain containing protein 0.0036 0.0243 0.0729
Brugia malayi hypothetical protein 0.0216 0.2953 0.884
Echinococcus multilocularis muscleblind protein 1 0.0148 0.1934 0.1934
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.4211 1
Schistosoma mansoni cpg binding protein 0.0028 0.0134 0.0134
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0245 0.052
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0478 0.1059
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0612 0.0879
Schistosoma mansoni lipoxygenase 0.0055 0.0529 0.0529
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0161 0.2132 0.2132
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0314 0.4438 0.5
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.008 0.0107
Echinococcus granulosus neuropeptide receptor A26 0.046 0.6629 0.6629
Leishmania major hypothetical protein, conserved 0.0036 0.0243 0.0498
Brugia malayi Bromodomain containing protein 0.0031 0.0176 0.0527
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.008 0.0107
Brugia malayi RNA, U transporter 1 0.0085 0.098 0.2934
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0388 0.0388
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.1836 0.3797
Schistosoma mansoni hypothetical protein 0.0318 0.4489 0.4489
Schistosoma mansoni alkaline phosphatase 0.0161 0.2132 0.2132
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0161 0.2132 0.2132
Schistosoma mansoni hypothetical protein 0.002 0.0014 0.0014
Brugia malayi CXXC zinc finger family protein 0.0028 0.0134 0.0402
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.029 0.4066 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0651 0.0651
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.008 0.0107
Schistosoma mansoni jumonji domain containing protein 0.0134 0.1715 0.1715
Loa Loa (eye worm) beta-lactamase 0.0036 0.0243 0.0541
Echinococcus granulosus phospholipase A 2 activating protein 0.0036 0.0243 0.0243
Echinococcus granulosus jumonji domain containing protein 0.004 0.0311 0.0311
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0318 0.4489 1
Giardia lamblia Fructose-bisphosphate aldolase 0.029 0.4066 1
Echinococcus multilocularis cpg binding protein 0.0032 0.0187 0.0187
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0025 0.008 0.0774
Onchocerca volvulus 0.0036 0.0243 0.0819
Brugia malayi RNA binding protein 0.0063 0.0651 0.1949
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0243 0.0727
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.4211 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.2136 0.2136
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0311 0.0311
Schistosoma mansoni zinc finger protein 0.0021 0.0022 0.0022
Brugia malayi beta-lactamase family protein 0.0036 0.0243 0.0727
Mycobacterium ulcerans hypothetical protein 0.0158 0.2079 0.4376
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.1838 0.4317
Loa Loa (eye worm) hypothetical protein 0.0036 0.0243 0.0541
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0612 0.0612
Echinococcus multilocularis alkaline phosphatase 0.0161 0.2132 0.2132
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0243 0.0514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0388 0.0388
Plasmodium falciparum polyubiquitin binding protein, putative 0.0036 0.0243 0.0548
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0245 0.0546
Plasmodium falciparum phd finger protein, putative 0.0029 0.0141 0.0317
Echinococcus granulosus snurportin 1 0.0318 0.4489 0.4489
Schistosoma mansoni importin beta-1 0.003 0.0154 0.0154
Onchocerca volvulus 0.0093 0.1112 0.3746
Echinococcus granulosus phd:f box containing protein 0.0025 0.008 0.008
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0245 0.052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.4066 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.2136 0.2136
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0612 0.0612
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.4066 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.0133 0.0133
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0141 0.0141
Echinococcus granulosus zinc finger protein 0.0021 0.0022 0.0022
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.1836 0.3797
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.1838 0.4317
Loa Loa (eye worm) hypothetical protein 0.007 0.0761 0.1695
Echinococcus multilocularis lysine specific demethylase 5A 0.0093 0.111 0.111
Schistosoma mansoni microtubule-associated protein tau 0.0684 1 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0339 0.0727
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0265 0.0265
Echinococcus multilocularis phd:f box containing protein 0.0025 0.008 0.008
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.063 0.063
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0134 0.0299
Trypanosoma brucei WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.0024 0.0068 0.0077
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0141 0.1825
Entamoeba histolytica hypothetical protein 0.0037 0.0265 0.0569
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0651 0.0651
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0069 0.008
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0314 0.4438 0.5
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0245 0.052
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0388 0.1162
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0612 1
Schistosoma mansoni hypothetical protein 0.0084 0.0966 0.0966
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0067 0.0067
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0044 0.0368 0.1102
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0153 0.2008 0.2008
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0141 0.0317
Echinococcus multilocularis snurportin 1 0.0318 0.4489 0.4489
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0036 0.0107
Plasmodium falciparum importin beta, putative 0.003 0.0154 0.0347
Schistosoma mansoni jumonji domain containing protein 0.0025 0.008 0.008
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.008 0.008
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0022 0.0067
Onchocerca volvulus 0.0217 0.2968 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0036 0.0036
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0245 0.0502
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0339 0.0727
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.4066 1
Echinococcus granulosus neuropeptide s receptor 0.046 0.6629 0.6629
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0141 0.0141
Leishmania major hypothetical protein, conserved 0.0036 0.0243 0.0497
Brugia malayi jmjC domain containing protein 0.0025 0.008 0.024
Schistosoma mansoni cpg binding protein 0.0032 0.0187 0.0187
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0299 0.4211 1
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0314 0.4438 1
Schistosoma mansoni alpha-glucosidase 0.0139 0.1798 0.1798
Treponema pallidum fructose-bisphosphate aldolase 0.029 0.4066 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.0151
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0161 0.2132 0.2132
Echinococcus granulosus lysine specific demethylase 5A 0.0097 0.1163 0.1163
Brugia malayi hypothetical protein 0.0037 0.0265 0.0793
Schistosoma mansoni survival motor neuron protein 0.0044 0.0368 0.0368
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0388 0.0388
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0651 0.0651
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0154 0.2054
Echinococcus granulosus importin subunit beta 1 0.003 0.0154 0.0154
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.008 0.0181
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.008 0.0179
Plasmodium vivax SET domain protein, putative 0.0028 0.0125 0.0282
Loa Loa (eye worm) hypothetical protein 0.003 0.0154 0.0343
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0529 0.0529
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.2136 0.4759
Echinococcus granulosus histone lysine methyltransferase setb 0.0045 0.038 0.038
Loa Loa (eye worm) RNA binding protein 0.0063 0.0651 0.145
Loa Loa (eye worm) hypothetical protein 0.0036 0.0243 0.0541
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0243 0.0514
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.008 0.0179
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0161 0.2132 0.2132
Echinococcus granulosus cpg binding protein 0.0032 0.0187 0.0187
Loa Loa (eye worm) jmjC domain-containing protein 0.0097 0.1163 0.259
Loa Loa (eye worm) hypothetical protein 0.004 0.0314 0.0699
Schistosoma mansoni ran 0.0022 0.0036 0.0036
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.4066 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.2136 0.6396
Schistosoma mansoni protein phosphatase 2C 0.0025 0.008 0.008
Echinococcus granulosus intestinal type alkaline phosphatase 0.0161 0.2132 0.2132
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0067 0.0067
Brugia malayi Pre-SET motif family protein 0.0028 0.0125 0.0375
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0388 0.0388
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.008 0.008
Schistosoma mansoni ran 0.0022 0.0036 0.0036
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0028 0.0125 0.1554
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.4066 1
Brugia malayi PHD-finger family protein 0.0029 0.0141 0.0421
Loa Loa (eye worm) WD domain-containing protein 0.0024 0.0068 0.0151
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0314 0.4438 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.1836 1
Echinococcus multilocularis survival motor neuron protein 1 0.0216 0.2953 0.2953
Schistosoma mansoni cpg binding protein 0.0032 0.0187 0.0187
Trypanosoma cruzi WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.0036 0.0243 0.0498
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0245 0.052
Trichomonas vaginalis phospholipase A-2-activating protein, putative 0.0036 0.0243 0.0516
Brugia malayi jmjC domain containing protein 0.0097 0.1163 0.3481
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0179
Loa Loa (eye worm) hypothetical protein 0.0065 0.0685 0.1527
Entamoeba histolytica hypothetical protein 0.0023 0.0057 0.0053
Toxoplasma gondii hypothetical protein 0.0048 0.0433 0.689
Brugia malayi Bromodomain containing protein 0.0076 0.0849 0.2542
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0651 0.145
Loa Loa (eye worm) hypothetical protein 0.0044 0.0366 0.0816
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.2079 0.4376
Trypanosoma cruzi WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.0036 0.0243 0.0498
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0154 0.0283
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.032 0.0707
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0161 0.2132 0.2132
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0612 0.0879
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0388 0.0388
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0568 0.9241
Brugia malayi jmjC domain containing protein 0.0153 0.2008 0.601
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0314 0.4438 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0243 0.0541
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.4066 1
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.008 0.008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0045 0.038 0.038
Plasmodium vivax JmjC domain containing protein 0.0025 0.008 0.0181
Onchocerca volvulus 0.0036 0.0243 0.0819
Brugia malayi Pre-SET motif family protein 0.0191 0.2573 0.7703
Loa Loa (eye worm) hypothetical protein 0.0038 0.0278 0.062
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0388 0.0865
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0069 0.0083
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0243 0.0547
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.1838 0.4317
Loa Loa (eye worm) hypothetical protein 0.0036 0.0243 0.0541
Echinococcus multilocularis peregrin 0.0031 0.0176 0.0176
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.0133 0.0133
Echinococcus granulosus survival motor neuron protein 1 0.0216 0.2953 0.2953
Onchocerca volvulus 0.0028 0.0134 0.0453
Echinococcus multilocularis phospholipase A 2 activating protein 0.0036 0.0243 0.0243
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.032 0.0707
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0339 0.0727
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0045 0.038 0.038
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0067 0.0067
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0141 0.1825
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0028 0.0125 0.0125
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0245 0.052
Brugia malayi TAR-binding protein 0.0063 0.0651 0.1949
Trichomonas vaginalis esterase, putative 0.0036 0.0243 0.0514
Trypanosoma brucei glucosidase, putative 0.0036 0.0245 0.0502
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0604 0.1345
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0026 0.0101 0.0101
Brugia malayi PHD-finger family protein 0.0026 0.0102 0.0305
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0314 0.4438 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0245 0.052
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.032 0.0707
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0529 0.0529
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0388 0.0388
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0612 0.0879
Brugia malayi Bromodomain containing protein 0.0038 0.0277 0.083
Entamoeba histolytica hypothetical protein 0.0024 0.0069 0.0083
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0154 0.0283
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.008 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0245 0.0502
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0265 0.0265
Plasmodium vivax importin-beta 2, putative 0.003 0.0154 0.0347
Brugia malayi jmjC domain containing protein 0.0025 0.008 0.024
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.008 0.008
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0243 0.0514
Brugia malayi follicle stimulating hormone receptor 0.0242 0.334 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0141 0.0141
Echinococcus granulosus muscleblind protein 0.0148 0.1934 0.1934
Schistosoma mansoni phospholipase A-2-activating protein 0.0024 0.0068 0.0068
Echinococcus multilocularis microtubule associated protein 2 0.0684 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0097 0.1163 0.1163
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0028 0.0125 0.0125
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0036 0.008
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.032 0.0707
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0651 0.1949
Brugia malayi Importin beta-1 subunit 0.003 0.0154 0.0461
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0243 0.0497
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.2136 0.2136
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.008 0.008
Schistosoma mansoni alpha-glucosidase 0.0139 0.1798 0.1798
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.008 0.008
Onchocerca volvulus 0.0028 0.0125 0.0422
Loa Loa (eye worm) hypothetical protein 0.0216 0.2953 0.6578
Trichomonas vaginalis set domain proteins, putative 0.0217 0.2968 0.7275
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0045 0.038 0.038
Loa Loa (eye worm) hypothetical protein 0.0036 0.0243 0.0541
Loa Loa (eye worm) hypothetical protein 0.0148 0.1934 0.4309
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0243 0.0497
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0651 0.145
Loa Loa (eye worm) hypothetical protein 0.0036 0.0243 0.0541
Loa Loa (eye worm) hypothetical protein 0.0036 0.0243 0.0541
Entamoeba histolytica hypothetical protein 0.0037 0.0265 0.0569
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.032 0.0707
Brugia malayi jmjC domain containing protein 0.0025 0.008 0.024
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0245 0.0502
Echinococcus multilocularis muscleblind protein 0.0148 0.1934 0.1934
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0339 0.0727
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0651 0.0651
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0243 0.0243
Schistosoma mansoni alkaline phosphatase 0.0161 0.2132 0.2132
Schistosoma mansoni hypothetical protein 0.0037 0.0265 0.0265
Echinococcus multilocularis neuropeptide receptor A26 0.046 0.6629 0.6629
Echinococcus multilocularis neuropeptide s receptor 0.046 0.6629 0.6629
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0141 0.0314
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0029 0.0141 0.0314
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0242 0.334 0.7441
Schistosoma mansoni hypothetical protein 0.0029 0.0141 0.0141
Echinococcus granulosus tar DNA binding protein 0.0063 0.0651 0.0651
Onchocerca volvulus Alhambra homolog 0.0029 0.0141 0.0474
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0191 0.2573 0.5732
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0243 0.0243
Onchocerca volvulus 0.0044 0.0368 0.124
Schistosoma mansoni phd/f-box containing protein 0.0025 0.008 0.008
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.008 0.0179
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0243 0.0514
Onchocerca volvulus 0.0036 0.0243 0.0819
Toxoplasma gondii PUL domain-containing protein 0.0036 0.0243 0.3607

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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