Detailed information for compound 573771

Basic information

Technical information
  • TDR Targets ID: 573771
  • Name: 4-(4-nitrophenoxy)aniline
  • MW: 230.219 | Formula: C12H10N2O3
  • H donors: 1 H acceptors: 2 LogP: 2.6 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc(cc1)Oc1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C12H10N2O3/c13-9-1-5-11(6-2-9)17-12-7-3-10(4-8-12)14(15)16/h1-8H,13H2
  • InChiKey: ASAOLTVUTGZJST-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-(4-nitrophenoxy)phenyl]amine
  • 4-amino-4'-nitrodiphenyl ether
  • NCIOpen2_004099
  • ZINC01620680
  • Benzenamine, 4-(4-nitrophenoxy)-
  • NSC74273
  • ST5340268
  • 4-Amino-4'-nitro-diphenyl ether
  • Oprea1_681434
  • CCRIS 8022
  • EINECS 228-159-3

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0118 0.039
Brugia malayi Augmenter of liver regeneration 0.0034 0.01 0.0344
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0541 0.2531
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0011 0.003
Schistosoma mansoni ferritin 0.0027 0.0058 0.0156
Loa Loa (eye worm) hypothetical protein 0.0298 0.1532 0.5251
Schistosoma mansoni chromobox protein 0.0071 0.0297 0.0799
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0043 0.0116
Brugia malayi Bromodomain containing protein 0.0041 0.0134 0.046
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0118 0.0318
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, beta chain PheT 0.0018 0.0011 0.0011
Brugia malayi phenylalanyl-tRNA synthetase, mitochondrial precursor, putative 0.0182 0.0904 0.3103
Echinococcus multilocularis zinc finger protein 0.0021 0.0026 0.007
Echinococcus granulosus muscleblind protein 0.0298 0.1532 0.4121
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0018
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0177 0.0591
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0082 0.0283
Leishmania major trypanothione reductase 0.0046 0.0164 0.0775
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0018
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0082 0.0388
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0265 0.1247
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0265 0.1247
Schistosoma mansoni phenylalanyl-tRNA synthetase mitochondrial 0.0182 0.0904 0.2431
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.01 0.0472
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0297 0.1004
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.012 0.0324
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0005 0.0014
Loa Loa (eye worm) phenylalanyl-tRNA synthetase 0.0182 0.0904 0.3091
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0011 0.003
Loa Loa (eye worm) glutathione reductase 0.0046 0.0164 0.0548
Schistosoma mansoni zinc finger protein 0.0016 0.0001 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0065 0.0224
Echinococcus granulosus chromobox protein 1 0.0071 0.0297 0.0799
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0265 0.1247
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0188 0.0506
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0248 0.0666
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0133 0.0636 0.2183
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.01 0.0472
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0077 0.0208
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0265 0.1247
Brugia malayi jmjC domain containing protein 0.0038 0.0118 0.0406
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0043 0.0116
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0226 0.0609
Mycobacterium leprae Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.0273 0.1398 1
Echinococcus granulosus microtubule associated protein 2 0.07 0.3717 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0487 0.0487
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0164 0.0442
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0182 0.0904 0.4262
Giardia lamblia PHD finger protein 15 0.003 0.0074 0.0347
Brugia malayi glutathione reductase 0.0046 0.0164 0.0565
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0541 0.1841
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0226 0.0609
Loa Loa (eye worm) hypothetical protein 0.0406 0.2121 0.7276
Echinococcus granulosus phenylalanyl tRNA synthetase 0.0182 0.0904 0.2431
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit alpha 0.1855 1 1
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0024
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0248 0.0248
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0074 0.0198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0082 0.0283
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0128 0.044
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0016 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Schistosoma mansoni inositol monophosphatase 0.0037 0.0116 0.0313
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0177 0.0476
Echinococcus multilocularis peregrin 0.0032 0.0087 0.0235
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0074 0.0198
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0082 0.0082
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0005 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0265 0.1247
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.01 0.0269
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0016 0.0078
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0189 0.0892
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0541 0.1856
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0043 0.0116
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0095 0.0428 0.147
Leishmania major hypothetical protein, conserved 0.0016 0.0001 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0265 0.1247
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0082 0.0283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Plasmodium vivax SET domain protein, putative 0.003 0.0077 0.0365
Echinococcus granulosus cathepsin l1 0.0017 0.0005 0.0014
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0016 0.0057
Brugia malayi Inositol-1 0.0037 0.0116 0.04
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0005 0.0014
Onchocerca volvulus 0.0051 0.0188 0.1509
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0188 0.0506
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0164 0.0164
Echinococcus multilocularis survival motor neuron protein 1 0.0465 0.244 0.6564
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0016 0.0078
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0027 0.0058 0.0058
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0107 0.0289
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0144 0.0496
Giardia lamblia Phenylalanyl-tRNA synthetase alpha chain 0.0406 0.2121 1
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.01 0.0472
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0082 0.0283
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0176 0.0473
Schistosoma mansoni hypothetical protein 0.0022 0.0032 0.0086
Mycobacterium ulcerans bacterioferritin BfrA 0.0027 0.0058 0.0058
Schistosoma mansoni glutaminase 0.0552 0.2913 0.7836
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0082 0.0283
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0406 0.2121 0.7281
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0116 0.04
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0487 0.0487
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0005 0.0014
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0016 0.0078
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0177 0.0476
Schistosoma mansoni apoferritin-2 0.0027 0.0058 0.0156
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0177 0.0608
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0144 0.1148
Loa Loa (eye worm) MBCTL1 0.0058 0.0226 0.0761
Trypanosoma cruzi ISWI complex protein 0.0016 0.0001 0.0005
Trichomonas vaginalis set domain proteins, putative 0.024 0.1219 0.4184
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0074 0.0198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Schistosoma mansoni ferritin light chain 0.0027 0.0058 0.0156
Echinococcus multilocularis microtubule associated protein 2 0.07 0.3717 1
Echinococcus multilocularis 6 phosphofructokinase 0.0115 0.0541 0.1454
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0248 0.0666
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0082 0.0365
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0082 0.0388
Loa Loa (eye worm) hypothetical protein 0.004 0.0128 0.0423
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0027 0.0058 0.0058
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.01 0.0472
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0024
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0136 0.0367
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0018
Brugia malayi phosphofructokinase 0.0115 0.0541 0.1856
Onchocerca volvulus 0.024 0.1219 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0176 0.0473
Plasmodium falciparum thioredoxin reductase 0.0046 0.0164 0.0775
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0226 0.0609
Brugia malayi mbt repeat family protein 0.0051 0.0188 0.0646
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0248 0.1167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Brugia malayi PHD-finger family protein 0.003 0.0074 0.0252
Treponema pallidum phenylalanyl-tRNA synthetase subunit alpha 0.0406 0.2121 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0541 0.2549
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.01 0.0269
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.0439 0.1182
Brugia malayi Bromodomain containing protein 0.0032 0.0087 0.0299
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0016 0.0016
Schistosoma mansoni ferritin 0.0027 0.0058 0.0156
Trypanosoma cruzi phenylalanyl-tRNA synthetase alpha chain, putative 0.0406 0.2121 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0018
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0541 0.1841
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0176 0.0473
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0133 0.0636 0.2183
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0018
Leishmania major hypothetical protein, conserved 0.0034 0.01 0.0472
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0128 0.1014
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0082 0.0388
Brugia malayi jmjC domain containing protein 0.0097 0.0439 0.1508
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0115 0.0541 0.3602
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0116 0.0549
Brugia malayi PHD-finger family protein 0.0026 0.0057 0.0195
Echinococcus multilocularis neuropeptide receptor A26 0.0491 0.2583 0.695
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0011 0.003
Brugia malayi Pre-SET motif family protein 0.003 0.0077 0.0266
Loa Loa (eye worm) hypothetical protein 0.0298 0.1532 0.5251
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0265 0.1247
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0018
Toxoplasma gondii thioredoxin reductase 0.0046 0.0164 0.0775
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit beta 0.0018 0.0011 0.0011
Echinococcus granulosus neuropeptide s receptor 0.0491 0.2583 0.695
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0018
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0136 0.0367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0005 0.0014
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0095 0.0095
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0541 0.1454
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.01 0.0472
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0016 0.0057
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0116 0.0116
Schistosoma mansoni survival motor neuron protein 0.0095 0.0428 0.1152
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0245 0.0824
Onchocerca volvulus 0.0031 0.0082 0.063
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0188 0.0506
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.01 0.0472
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0016 0.0039
Loa Loa (eye worm) hypothetical protein 0.0051 0.0188 0.063
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0541 0.1856
Toxoplasma gondii phenylalanyl-tRNA synthetase alpha chain A, putative 0.0406 0.2121 1
Echinococcus multilocularis phenylalanyl tRNA synthetase 0.0182 0.0904 0.2431
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0177 0.0476
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0188 0.0506
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.012 0.0324
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0005 0.0024
Echinococcus multilocularis chromobox protein 1 0.0071 0.0297 0.0799
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0265 0.1247
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0188 0.0506
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0027 0.0058 0.0058
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0032 0.0092
Brugia malayi 6-phosphofructokinase 0.0115 0.0541 0.1856
Brugia malayi Heterochromatin protein 1 0.0071 0.0297 0.1019
Schistosoma mansoni apoferritin-2 0.0027 0.0058 0.0156
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0487 0.0487
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0016 0.0016
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.106 0.3629
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0116 0.0549
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0188 0.063
Loa Loa (eye worm) glutaminase 0.0552 0.2913 1
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.1855 1 1
Brugia malayi mbt repeat family protein 0.0051 0.0188 0.0646
Plasmodium falciparum phenylalanine--tRNA ligase 0.0182 0.0904 0.4262
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0248 0.0666
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0005 0.0024
Schistosoma mansoni inositol monophosphatase 0.0037 0.0116 0.0313
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0041 0.0134 0.0445
Plasmodium vivax vivapain-2 0.0017 0.0005 0.0024
Plasmodium vivax phenylalanine--tRNA ligase alpha subunit, putative 0.0406 0.2121 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0226 0.0761
Brugia malayi Thioredoxin reductase 0.0046 0.0164 0.0565
Echinococcus granulosus phenylalanyl tRNA synthetase alpha chain B 0.0406 0.2121 0.5705
Brugia malayi hypothetical protein 0.0465 0.244 0.8377
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0164 0.0775
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0133 0.0636 0.2998
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0016 0.0078
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0551 0.0551
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0541 0.2531
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0115 0.0541 0.2549
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0018
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0541 0.2549
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0265 0.1247
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0226 0.0609
Echinococcus multilocularis cysteine protease 0.0017 0.0005 0.0014
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0005 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0128 0.044
Echinococcus multilocularis muscleblind protein 0.0298 0.1532 0.4121
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0226 0.0609
Toxoplasma gondii exonuclease III APE 0.0019 0.0016 0.0078
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0011 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0018
Schistosoma mansoni zinc finger protein 0.0021 0.0026 0.007
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0082 0.0388
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0118 0.0318
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0018
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0258 0.0693
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0082 0.0388
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0005 0.0018
Schistosoma mansoni hypothetical protein 0.0312 0.1608 0.4327
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0248 0.0248
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0177 0.0476
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit alpha 0.1855 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0491 0.2583 0.695
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0248 0.0666
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0164 0.0548
Brugia malayi Pre-SET motif family protein 0.0211 0.106 0.364
Mycobacterium ulcerans 6-phosphofructokinase 0.0115 0.0541 0.0541
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0331 0.089
Plasmodium vivax hypothetical protein, conserved 0.003 0.0074 0.0347
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0406 0.2121 0.5705
Trypanosoma brucei phenylalanyl-tRNA synthetase alpha chain, putative 0.0406 0.2121 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0487 0.0487
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0024
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0074 0.0347
Echinococcus multilocularis expressed protein 0.0027 0.0058 0.0156
Loa Loa (eye worm) phosphofructokinase 0.0115 0.0541 0.1841
Leishmania major phenylalanyl-tRNA synthetase alpha chain, putative 0.0406 0.2121 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0018
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.01 0.0472
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0005 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0065 0.0224
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0071 0.0192
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0116 0.0526
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0116 0.0549
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0024
Echinococcus granulosus ferritin 0.0027 0.0058 0.0156
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0016 0.0044
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0248 0.0248
Brugia malayi chromobox protein homolog 3 0.004 0.0128 0.044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0265 0.1247
Leishmania major cathepsin L-like protease 0.0065 0.0265 0.1247
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0551 0.3679
Echinococcus multilocularis chromobox protein 1 0.0071 0.0297 0.0799
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0116 0.0313
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0265 0.1247
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0116 0.0313
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.01 0.0472
Schistosoma mansoni microtubule-associated protein tau 0.07 0.3717 1
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0003
Echinococcus granulosus chromobox protein 1 0.0071 0.0297 0.0799
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0074 0.0235
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0541 0.1856
Onchocerca volvulus 0.0095 0.0428 0.3487
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0176 0.0473
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0188 0.0506
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0082 0.0283
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.01 0.0327
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0005 0.0018
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0095 0.0277
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Schistosoma mansoni hypothetical protein 0.0095 0.0428 0.1152
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0018
Leishmania major cathepsin L-like protease 0.0065 0.0265 0.1247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0116 0.0549
Mycobacterium ulcerans glutaminase 0.0552 0.2913 0.2913
Echinococcus granulosus expressed protein 0.0027 0.0058 0.0156
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0265 0.1247
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0177 0.0476
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0188 0.0506
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0005 0.0014
Schistosoma mansoni chromobox protein 0.0071 0.0297 0.0799
Mycobacterium tuberculosis Probable reductase 0.0106 0.0487 0.0487
Brugia malayi 6-phosphofructokinase 0.0115 0.0541 0.1856
Echinococcus granulosus peregrin 0.0032 0.0087 0.0235
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0082 0.0388
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0203 0.1019 0.2742
Loa Loa (eye worm) hypothetical protein 0.003 0.0074 0.0235
Leishmania major cathepsin L-like protease 0.0065 0.0265 0.1247
Echinococcus granulosus 6 phosphofructokinase 0.0115 0.0541 0.1454
Echinococcus multilocularis phenylalanyl tRNA synthetase alpha chain B 0.0406 0.2121 0.5705
Echinococcus multilocularis ferritin 0.0027 0.0058 0.0156
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0118 0.0318
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0005 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0005 0.0018
Loa Loa (eye worm) hypothetical protein 0.0075 0.0321 0.1087
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0226 0.0777
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0016 0.0078
Schistosoma mansoni bromodomain containing protein 0.0067 0.0278 0.0749
Loa Loa (eye worm) glutaminase 2 0.0552 0.2913 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0177 0.0476
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0116 0.0116
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0016 0.0078
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0133 0.0636 0.171
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0297 0.1019
Brugia malayi glutaminase DH11.1 0.0552 0.2913 1
Plasmodium falciparum phenylalanine--tRNA ligase 0.0151 0.0734 0.3462
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0551 0.0551
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0265 0.1247
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0016 0.0054
Echinococcus granulosus zinc finger protein 0.0021 0.0026 0.007
Treponema pallidum bacterioferrin (TpF1) 0.0027 0.0058 0.0273
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0164 0.0442
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0005 0.0014
Mycobacterium ulcerans bacterioferritin BfrB 0.0027 0.0058 0.0058
Schistosoma mansoni ferritin 0.0027 0.0058 0.0156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Plasmodium vivax vivapain-2 0.0017 0.0005 0.0024
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0015 0.0033
Echinococcus granulosus neuropeptide receptor A26 0.0491 0.2583 0.695
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0541 0.1856
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0265 0.1247
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0297 0.1019
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0203 0.1019 0.2742
Trypanosoma brucei trypanothione reductase 0.0046 0.0164 0.0775
Leishmania major ATP-dependent phosphofructokinase 0.0115 0.0541 0.2549
Brugia malayi Muscleblind-like protein 0.0298 0.1532 0.526
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0551 0.0551
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0082 0.0388
Schistosoma mansoni ferritin light chain 0.0027 0.0058 0.0156
Toxoplasma gondii Ferredoxin-fold anticodon binding domain-containing protein 0.0182 0.0904 0.4262
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0082 0.0082
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0016 0.0057
Trypanosoma brucei ISWI complex protein 0.0016 0.0001 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0018
Plasmodium vivax glutathione reductase, putative 0.0046 0.0164 0.0775
Toxoplasma gondii cathepsin CPL 0.0017 0.0005 0.0024
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0077 0.0365
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit beta 0.0018 0.0011 0.0011
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0115 0.0541 0.0541
Loa Loa (eye worm) hypothetical protein 0.0048 0.0176 0.0587
Loa Loa (eye worm) hypothetical protein 0.0031 0.0082 0.0263
Schistosoma mansoni ap endonuclease 0.0019 0.0016 0.0044
Loa Loa (eye worm) hypothetical protein 0.0045 0.0159 0.053
Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit 0.0406 0.2121 1
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0541 0.1454
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0116 0.04
Echinococcus granulosus survival motor neuron protein 1 0.0465 0.244 0.6564
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0074 0.0347
Trichomonas vaginalis glutaminase, putative 0.0552 0.2913 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0188 0.063
Echinococcus multilocularis cysteine protease 0.0017 0.0005 0.0014
Schistosoma mansoni ferritin 0.0027 0.0058 0.0156
Schistosoma mansoni hypothetical protein 0.003 0.0074 0.0198
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0487 0.3201
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0018
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0248 0.1167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0265 0.1247
Echinococcus multilocularis muscleblind protein 1 0.0298 0.1532 0.4121
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0188 0.1509
Brugia malayi Bromodomain containing protein 0.008 0.0346 0.1188
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0164 0.0775
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0016 0.0078
Loa Loa (eye worm) hypothetical protein 0.0465 0.244 0.8375
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0082 0.0388
Onchocerca volvulus 0.0042 0.014 0.1113
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0082 0.0283
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0077 0.0208
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0234 0.1103
Plasmodium falciparum glutathione reductase 0.0046 0.0164 0.0775
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0144 0.0496
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0005 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0177 0.0476
Onchocerca volvulus Alhambra homolog 0.003 0.0074 0.0564
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0024
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0258 0.0693
Chlamydia trachomatis phenylalanine--tRNA ligase subunit beta 0.0018 0.0011 0.0011
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.0439 0.1182
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0116 0.04
Loa Loa (eye worm) hypothetical protein 0.0043 0.0148 0.0492
Plasmodium falciparum phd finger protein, putative 0.003 0.0074 0.0347
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0248 0.0248
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0082 0.0388
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0018
Brugia malayi phenylalanyl (f) trna synthetase protein 1 0.0406 0.2121 0.7281
Schistosoma mansoni ap endonuclease 0.0019 0.0016 0.0044
Entamoeba histolytica phenylalanyl-tRNA synthetase alpha subunit, putative 0.0406 0.2121 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0487 0.0487
Trypanosoma cruzi ISWI complex protein 0.0016 0.0001 0.0005
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0541 0.2531
Trichomonas vaginalis ferritin, putative 0.0027 0.0058 0.0199
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.014 0.0377
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0116 0.0549
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0016 0.0078
Loa Loa (eye worm) inositol-1 0.0037 0.0116 0.0383

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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