Detailed information for compound 574168

Basic information

Technical information
  • TDR Targets ID: 574168
  • Name: 1-nitro-4-phenoxy-benzene
  • MW: 215.205 | Formula: C12H9NO3
  • H donors: 0 H acceptors: 2 LogP: 3.28 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc(cc1)Oc1ccccc1
  • InChi: 1S/C12H9NO3/c14-13(15)10-6-8-12(9-7-10)16-11-4-2-1-3-5-11/h1-9H
  • InChiKey: JDTMUJBWSGNMGR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-nitro-4-phenoxybenzene
  • 1-nitro-4-(phenoxy)benzene
  • 1-nitro-4-(phenyloxy)benzene
  • 4-06-00-01287 (Beilstein Handbook Reference)
  • 4-nitrobiphenyl ether
  • 4-Nitrodifenylether
  • 4-Nitrodifenylether [Czech]
  • 4-Nitrodiphenyl ether
  • 4-Nitrophenyl phenyl ether
  • 620-88-2
  • AI3-09331
  • Benzene, 1-nitro-4-phenoxy-
  • BRN 2051911
  • CCRIS 1947
  • EINECS 210-656-1
  • Ether, 4-nitrophenyl phenyl
  • Ether, p-nitrophenyl phenyl
  • Ether, p-nitrophenyl phenyl (8CI)
  • N21901_ALDRICH
  • NSC 5420
  • NSC 57080
  • NSC5420
  • NSC57080
  • p-Nitrodiphenyl ether
  • p-Nitrophenyl phenyl ether
  • p-Nitrophenyl phenylether
  • Phenyl, 4'-nitrophenyl ether
  • ST5406170
  • WLN: WNR DOR
  • ZINC01686935

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0043 0.0116
Loa Loa (eye worm) inositol-1 0.0037 0.0116 0.0383
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0016 0.0016
Brugia malayi Bromodomain containing protein 0.008 0.0346 0.1188
Echinococcus granulosus muscleblind protein 0.0298 0.1532 0.4121
Toxoplasma gondii Ferredoxin-fold anticodon binding domain-containing protein 0.0182 0.0904 0.4262
Loa Loa (eye worm) hypothetical protein 0.0045 0.0159 0.053
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0133 0.0636 0.2183
Loa Loa (eye worm) hypothetical protein 0.0298 0.1532 0.5251
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0248 0.1167
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0248 0.0666
Onchocerca volvulus 0.0095 0.0428 0.3487
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0541 0.1856
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0182 0.0904 0.4262
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0116 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0265 0.1247
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0164 0.0442
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.1855 1 1
Mycobacterium leprae Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.0273 0.1398 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0487 0.0487
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0116 0.0549
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0027 0.0058 0.0058
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0016 0.0078
Mycobacterium ulcerans bacterioferritin BfrB 0.0027 0.0058 0.0058
Toxoplasma gondii thioredoxin reductase 0.0046 0.0164 0.0775
Onchocerca volvulus 0.0042 0.014 0.1113
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0248 0.1167
Echinococcus multilocularis peregrin 0.0032 0.0087 0.0235
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0541 0.2549
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0082 0.0283
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.01 0.0327
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0095 0.0277
Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit 0.0406 0.2121 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.014 0.0377
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0248 0.0248
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0027 0.0058 0.0058
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0297 0.1004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0018
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0248 0.0666
Plasmodium falciparum phd finger protein, putative 0.003 0.0074 0.0347
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0248 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0065 0.0224
Plasmodium vivax vivapain-2 0.0017 0.0005 0.0024
Trypanosoma cruzi ISWI complex protein 0.0016 0.0001 0.0005
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0016 0.0044
Leishmania major phenylalanyl-tRNA synthetase alpha chain, putative 0.0406 0.2121 1
Leishmania major cathepsin L-like protease 0.0065 0.0265 0.1247
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0265 0.1247
Plasmodium falciparum phenylalanine--tRNA ligase 0.0182 0.0904 0.4262
Schistosoma mansoni zinc finger protein 0.0021 0.0026 0.007
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0082 0.0283
Echinococcus granulosus ferritin 0.0027 0.0058 0.0156
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0074 0.0347
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0541 0.2531
Schistosoma mansoni ap endonuclease 0.0019 0.0016 0.0044
Mycobacterium ulcerans 6-phosphofructokinase 0.0115 0.0541 0.0541
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0077 0.0208
Schistosoma mansoni ferritin 0.0027 0.0058 0.0156
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0011 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.01 0.0472
Trichomonas vaginalis ferritin, putative 0.0027 0.0058 0.0199
Echinococcus granulosus neuropeptide receptor A26 0.0491 0.2583 0.695
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0015 0.0033
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0116 0.0549
Echinococcus multilocularis 6 phosphofructokinase 0.0115 0.0541 0.1454
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0297 0.1019
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0234 0.1103
Loa Loa (eye worm) hypothetical protein 0.0406 0.2121 0.7276
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0005 0.0014
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, beta chain PheT 0.0018 0.0011 0.0011
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0164 0.0164
Trichomonas vaginalis glutaminase, putative 0.0552 0.2913 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0082 0.0388
Loa Loa (eye worm) hypothetical protein 0.0465 0.244 0.8375
Brugia malayi Bromodomain containing protein 0.0041 0.0134 0.046
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0016 0.0057
Loa Loa (eye worm) glutaminase 0.0552 0.2913 1
Brugia malayi mbt repeat family protein 0.0051 0.0188 0.0646
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0018
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0116 0.0549
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0188 0.0506
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0005 0.0024
Onchocerca volvulus 0.0051 0.0188 0.1509
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0082 0.0388
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0074 0.0347
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0245 0.0824
Brugia malayi Thioredoxin reductase 0.0046 0.0164 0.0565
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0265 0.1247
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0551 0.0551
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0016 0.0039
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0487 0.0487
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit beta 0.0018 0.0011 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0265 0.1247
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0005 0.0014
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0226 0.0609
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0541 0.1856
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0115 0.0541 0.2549
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.012 0.0324
Plasmodium falciparum thioredoxin reductase 0.0046 0.0164 0.0775
Trypanosoma brucei phenylalanyl-tRNA synthetase alpha chain, putative 0.0406 0.2121 1
Echinococcus multilocularis zinc finger protein 0.0021 0.0026 0.007
Schistosoma mansoni glutaminase 0.0552 0.2913 0.7836
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0115 0.0541 0.3602
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0164 0.0548
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0265 0.1247
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0551 0.0551
Loa Loa (eye worm) hypothetical protein 0.0298 0.1532 0.5251
Onchocerca volvulus Alhambra homolog 0.003 0.0074 0.0564
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0016 0.0078
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0248 0.0666
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0005 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0005 0.0018
Leishmania major trypanothione reductase 0.0046 0.0164 0.0775
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0016 0.0057
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0116 0.0549
Echinococcus multilocularis chromobox protein 1 0.0071 0.0297 0.0799
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0265 0.1247
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0541 0.1856
Echinococcus multilocularis expressed protein 0.0027 0.0058 0.0156
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.01 0.0472
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.0439 0.1182
Brugia malayi 6-phosphofructokinase 0.0115 0.0541 0.1856
Echinococcus multilocularis cysteine protease 0.0017 0.0005 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0018
Trypanosoma brucei trypanothione reductase 0.0046 0.0164 0.0775
Trypanosoma cruzi ISWI complex protein 0.0016 0.0001 0.0005
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0118 0.0318
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0005 0.0024
Brugia malayi Augmenter of liver regeneration 0.0034 0.01 0.0344
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0203 0.1019 0.2742
Leishmania major hypothetical protein, conserved 0.0016 0.0001 0.0005
Giardia lamblia Phenylalanyl-tRNA synthetase alpha chain 0.0406 0.2121 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0018
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0005 0.0014
Schistosoma mansoni ferritin light chain 0.0027 0.0058 0.0156
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.01 0.0472
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0011 0.003
Schistosoma mansoni chromobox protein 0.0071 0.0297 0.0799
Echinococcus multilocularis neuropeptide receptor A26 0.0491 0.2583 0.695
Echinococcus granulosus survival motor neuron protein 1 0.0465 0.244 0.6564
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0032 0.0092
Echinococcus multilocularis microtubule associated protein 2 0.07 0.3717 1
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0024
Brugia malayi mbt repeat family protein 0.0051 0.0188 0.0646
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0136 0.0367
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0077 0.0365
Echinococcus granulosus phenylalanyl tRNA synthetase 0.0182 0.0904 0.2431
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0541 0.1454
Echinococcus granulosus chromobox protein 1 0.0071 0.0297 0.0799
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0226 0.0609
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0082 0.0388
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.01 0.0472
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0024
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0541 0.1856
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0116 0.0526
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0016 0.0078
Echinococcus granulosus peregrin 0.0032 0.0087 0.0235
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0116 0.04
Schistosoma mansoni ferritin 0.0027 0.0058 0.0156
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0551 0.0551
Mycobacterium ulcerans bacterioferritin BfrA 0.0027 0.0058 0.0058
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0203 0.1019 0.2742
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0024
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0331 0.089
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0116 0.04
Plasmodium vivax phenylalanine--tRNA ligase alpha subunit, putative 0.0406 0.2121 1
Echinococcus multilocularis cysteine protease 0.0017 0.0005 0.0014
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0116 0.0313
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0133 0.0636 0.2183
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0133 0.0636 0.171
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0016 0.0078
Schistosoma mansoni apoferritin-2 0.0027 0.0058 0.0156
Loa Loa (eye worm) hypothetical protein 0.0043 0.0148 0.0492
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0082 0.0283
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0016 0.0078
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0116 0.0549
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0005 0.0024
Schistosoma mansoni inositol monophosphatase 0.0037 0.0116 0.0313
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0011 0.003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0176 0.0473
Trypanosoma brucei ISWI complex protein 0.0016 0.0001 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0005 0.0018
Plasmodium falciparum phenylalanine--tRNA ligase 0.0151 0.0734 0.3462
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0043 0.0116
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0144 0.1148
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0005 0.0018
Echinococcus multilocularis survival motor neuron protein 1 0.0465 0.244 0.6564
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0077 0.0208
Brugia malayi Bromodomain containing protein 0.0032 0.0087 0.0299
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0541 0.1841
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0265 0.1247
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0406 0.2121 0.5705
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0265 0.1247
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0136 0.0367
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0265 0.1247
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0248 0.0248
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0265 0.1247
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0024
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0541 0.2549
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0016 0.0078
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0487 0.0487
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0188 0.0506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Echinococcus granulosus cathepsin l1 0.0017 0.0005 0.0014
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0011 0.003
Loa Loa (eye worm) hypothetical protein 0.0051 0.0188 0.063
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0065 0.0224
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0177 0.0476
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0107 0.0289
Brugia malayi chromobox protein homolog 3 0.004 0.0128 0.044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0258 0.0693
Toxoplasma gondii phenylalanyl-tRNA synthetase alpha chain A, putative 0.0406 0.2121 1
Echinococcus granulosus zinc finger protein 0.0021 0.0026 0.007
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.01 0.0269
Leishmania major cathepsin L-like protease 0.0065 0.0265 0.1247
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0082 0.0388
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.012 0.0324
Schistosoma mansoni hypothetical protein 0.0095 0.0428 0.1152
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0188 0.0506
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0177 0.0591
Loa Loa (eye worm) phosphofructokinase 0.0115 0.0541 0.1841
Plasmodium vivax SET domain protein, putative 0.003 0.0077 0.0365
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0018
Schistosoma mansoni phenylalanyl-tRNA synthetase mitochondrial 0.0182 0.0904 0.2431
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0177 0.0476
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0082 0.0283
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0003
Schistosoma mansoni hypothetical protein 0.003 0.0074 0.0198
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.01 0.0472
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0128 0.044
Schistosoma mansoni ferritin 0.0027 0.0058 0.0156
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0116 0.0116
Echinococcus granulosus phenylalanyl tRNA synthetase alpha chain B 0.0406 0.2121 0.5705
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0487 0.0487
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0226 0.0777
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0005 0.0014
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0551 0.3679
Trypanosoma cruzi phenylalanyl-tRNA synthetase alpha chain, putative 0.0406 0.2121 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0176 0.0587
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0074 0.0198
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0144 0.0496
Echinococcus granulosus 6 phosphofructokinase 0.0115 0.0541 0.1454
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0005 0.0024
Leishmania major cathepsin L-like protease 0.0065 0.0265 0.1247
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0082 0.0388
Mycobacterium tuberculosis Probable reductase 0.0106 0.0487 0.0487
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0016 0.0057
Brugia malayi jmjC domain containing protein 0.0097 0.0439 0.1508
Brugia malayi phenylalanyl-tRNA synthetase, mitochondrial precursor, putative 0.0182 0.0904 0.3103
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0082 0.0283
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0541 0.1454
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0177 0.0476
Echinococcus multilocularis phenylalanyl tRNA synthetase alpha chain B 0.0406 0.2121 0.5705
Loa Loa (eye worm) phenylalanyl-tRNA synthetase 0.0182 0.0904 0.3091
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0265 0.1247
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0248 0.0666
Echinococcus multilocularis phenylalanyl tRNA synthetase 0.0182 0.0904 0.2431
Echinococcus multilocularis chromobox protein 1 0.0071 0.0297 0.0799
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0118 0.039
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0118 0.0318
Plasmodium vivax hypothetical protein, conserved 0.003 0.0074 0.0347
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.0439 0.1182
Echinococcus multilocularis ferritin 0.0027 0.0058 0.0156
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.01 0.0472
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0082 0.0388
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0265 0.1247
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0005 0.0014
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0164 0.0775
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit alpha 0.1855 1 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0188 0.1509
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0248 0.0248
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0176 0.0473
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0133 0.0636 0.2998
Loa Loa (eye worm) MBCTL1 0.0058 0.0226 0.0761
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0082 0.0283
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0487 0.3201
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0258 0.0693
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0188 0.0506
Brugia malayi Heterochromatin protein 1 0.0071 0.0297 0.1019
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0027 0.0058 0.0058
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.01 0.0472
Giardia lamblia PHD finger protein 15 0.003 0.0074 0.0347
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0226 0.0609
Treponema pallidum bacterioferrin (TpF1) 0.0027 0.0058 0.0273
Echinococcus granulosus microtubule associated protein 2 0.07 0.3717 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0118 0.0318
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0265 0.1247
Entamoeba histolytica phenylalanyl-tRNA synthetase alpha subunit, putative 0.0406 0.2121 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0005 0.0014
Brugia malayi PHD-finger family protein 0.0026 0.0057 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0128 0.044
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0177 0.0608
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0082 0.0388
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0177 0.0476
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0164 0.0442
Echinococcus granulosus neuropeptide s receptor 0.0491 0.2583 0.695
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0018
Onchocerca volvulus 0.0031 0.0082 0.063
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0177 0.0476
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.01 0.0269
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0164 0.0775
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0005 0.0014
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0188 0.0506
Treponema pallidum phenylalanyl-tRNA synthetase subunit alpha 0.0406 0.2121 1
Leishmania major hypothetical protein, conserved 0.0034 0.01 0.0472
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0082 0.0388
Brugia malayi Pre-SET motif family protein 0.003 0.0077 0.0266
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0297 0.1019
Echinococcus multilocularis muscleblind protein 0.0298 0.1532 0.4121
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0541 0.2531
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0074 0.0198
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0018
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0189 0.0892
Loa Loa (eye worm) hypothetical protein 0.004 0.0128 0.0423
Loa Loa (eye worm) hypothetical protein 0.0058 0.0226 0.0761
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0541 0.2531
Schistosoma mansoni survival motor neuron protein 0.0095 0.0428 0.1152
Echinococcus granulosus expressed protein 0.0027 0.0058 0.0156
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0016 0.0044
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0016 0.0078
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0043 0.0116
Loa Loa (eye worm) glutathione reductase 0.0046 0.0164 0.0548
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0188 0.0506
Brugia malayi Inositol-1 0.0037 0.0116 0.04
Chlamydia trachomatis phenylalanine--tRNA ligase subunit beta 0.0018 0.0011 0.0011
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.01 0.0472
Brugia malayi jmjC domain containing protein 0.0038 0.0118 0.0406
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0016 0.0016
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0226 0.0609
Brugia malayi hypothetical protein 0.0465 0.244 0.8377
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0144 0.0496
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit beta 0.0018 0.0011 0.0011
Brugia malayi PHD-finger family protein 0.003 0.0074 0.0252
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0265 0.1247
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.106 0.3629
Schistosoma mansoni ferritin light chain 0.0027 0.0058 0.0156
Echinococcus multilocularis muscleblind protein 1 0.0298 0.1532 0.4121
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0005 0.0024
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0226 0.0609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Schistosoma mansoni apoferritin-2 0.0027 0.0058 0.0156
Loa Loa (eye worm) hypothetical protein 0.0041 0.0134 0.0445
Plasmodium vivax vivapain-2 0.0017 0.0005 0.0024
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0018
Loa Loa (eye worm) hypothetical protein 0.0075 0.0321 0.1087
Schistosoma mansoni microtubule-associated protein tau 0.07 0.3717 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0115 0.0541 0.0541
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0082 0.0082
Leishmania major ATP-dependent phosphofructokinase 0.0115 0.0541 0.2549
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0082 0.0388
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0176 0.0473
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0071 0.0192
Schistosoma mansoni zinc finger protein 0.0016 0.0001 0.0003
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit alpha 0.1855 1 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0188 0.0506
Toxoplasma gondii exonuclease III APE 0.0019 0.0016 0.0078
Plasmodium vivax glutathione reductase, putative 0.0046 0.0164 0.0775
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0016 0.0054
Brugia malayi glutaminase DH11.1 0.0552 0.2913 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0176 0.0473
Schistosoma mansoni inositol monophosphatase 0.0037 0.0116 0.0313
Echinococcus multilocularis neuropeptide s receptor 0.0491 0.2583 0.695
Loa Loa (eye worm) hypothetical protein 0.0031 0.0082 0.0263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Trichomonas vaginalis set domain proteins, putative 0.024 0.1219 0.4184
Brugia malayi 6-phosphofructokinase 0.0115 0.0541 0.1856
Loa Loa (eye worm) hypothetical protein 0.003 0.0074 0.0235
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0018
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0016 0.0078
Brugia malayi phosphofructokinase 0.0115 0.0541 0.1856
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0116 0.04
Echinococcus granulosus chromobox protein 1 0.0071 0.0297 0.0799
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0188 0.063
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0074 0.0198
Brugia malayi glutathione reductase 0.0046 0.0164 0.0565
Toxoplasma gondii cathepsin CPL 0.0017 0.0005 0.0024
Schistosoma mansoni hypothetical protein 0.0312 0.1608 0.4327
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0082 0.0082
Brugia malayi phenylalanyl (f) trna synthetase protein 1 0.0406 0.2121 0.7281
Loa Loa (eye worm) hypothetical protein 0.0051 0.0188 0.063
Schistosoma mansoni bromodomain containing protein 0.0067 0.0278 0.0749
Mycobacterium ulcerans glutaminase 0.0552 0.2913 0.2913
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0082 0.0283
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0082 0.0365
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0095 0.0428 0.147
Schistosoma mansoni chromobox protein 0.0071 0.0297 0.0799
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0406 0.2121 0.7281
Schistosoma mansoni ap endonuclease 0.0019 0.0016 0.0044
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0487 0.0487
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0018
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0128 0.1014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0018
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0074 0.0235
Brugia malayi Pre-SET motif family protein 0.0211 0.106 0.364
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0018
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0018
Schistosoma mansoni ferritin 0.0027 0.0058 0.0156
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0177 0.0476
Loa Loa (eye worm) glutaminase 2 0.0552 0.2913 1
Onchocerca volvulus 0.024 0.1219 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0016 0.0016
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0116 0.0313
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0541 0.1841
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0095 0.0095
Brugia malayi Muscleblind-like protein 0.0298 0.1532 0.526
Schistosoma mansoni hypothetical protein 0.0022 0.0032 0.0086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0265 0.1247
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0177 0.0476
Plasmodium falciparum glutathione reductase 0.0046 0.0164 0.0775

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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