Detailed information for compound 577651

Basic information

Technical information
  • TDR Targets ID: 577651
  • Name: 6-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetr ahydrofuran-2-yl]imidazo[2,1-f]pyrimidin-5-on e
  • MW: 251.239 | Formula: C11H13N3O4
  • H donors: 2 H acceptors: 4 LogP: -0.46 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H](C[C@@H]1O)n1ccc2n(c1=O)ccn2
  • InChi: 1S/C11H13N3O4/c15-6-8-7(16)5-10(18-8)14-3-1-9-12-2-4-13(9)11(14)17/h1-4,7-8,10,15-16H,5-6H2/t7-,8+,10+/m0/s1
  • InChiKey: UFLBVEMEAYZXKY-QXFUBDJGSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-5-imidazo[2,1-f]pyrimidinone
  • 6-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazo[2,1-f]pyrimidin-5-one
  • 6-[(2R,4S,5R)-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]imidazo[2,1-f]pyrimidin-5-one
  • 3,N(4)-ethenodeoxycytidine
  • 6-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazo[1,2-c]pyrimidin-5-one
  • 6-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]imidazo[1,2-c]pyrimidin-5-one
  • 6-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-5-imidazo[1,2-c]pyrimidinone
  • 6-[(2R,4S,5R)-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]imidazo[1,2-c]pyrimidin-5-one
  • 68498-26-0
  • 6-(2-Deoxy-beta-D-erythro-pentofuranosyl)imidazo(1,2-c)pyrimidin-5(6H)-one
  • Imidazo(1,2-c)pyrimidin-5(6H)-one, 6-(2-deoxy-beta-D-erythro-pentofuranosyl)-
  • 3,N(4)-Etheno-2'-deoxycytidine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni smad1 5 8 and 0.0017 0.0003 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0039 0.105
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0002 0.0037
Leishmania major hypothetical protein, conserved 0.0027 0.0018 0.0676
Mycobacterium ulcerans TetR family transcriptional regulator 0.2174 0.3263 1
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2174 0.3263 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0046 0.0047 0.0601
Schistosoma mansoni hypothetical protein 0.0017 0.0002 0.0001
Brugia malayi beta-lactamase family protein 0.0073 0.0088 0.1128
Leishmania major NADH dehydrogenase, putative 0.0017 0.0002 0.0037
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0002 0.0026
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0088 0.3452
Brugia malayi hypothetical protein 0.053 0.0777 1
Schistosoma mansoni peptidase Clp (S14 family) 0.016 0.0219 0.0218
Echinococcus multilocularis glutamate synthase 0.0017 0.0002 0.0001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0088 0.0087
Schistosoma mansoni ferritin 0.0018 0.0004 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0081 0.008
Echinococcus granulosus lamin 0.0029 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0209 0.0293 0.3773
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0017 0.0002 0.0026
Schistosoma mansoni thyroid hormone receptor 0.0148 0.02 0.0199
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0048 0.0049 0.0048
Echinococcus multilocularis lamin dm0 0.0029 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0073 0.0088 0.1128
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0416 0.0605 0.1853
Loa Loa (eye worm) hypothetical protein 0.0073 0.0088 0.1128
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0048 0.0049 0.3066
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0416 0.0605 0.1853
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0063 0.0072 0.283
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0088 0.0263
Schistosoma mansoni hypothetical protein 0.0034 0.0027 0.0026
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0003 0.0038
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0002 0.0026
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.016 0.0219 0.0664
Mycobacterium ulcerans lipase LipD 0.0073 0.0088 0.0263
Loa Loa (eye worm) hypothetical protein 0.0027 0.0018 0.0231
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0416 0.0605 0.1853
Plasmodium vivax thioredoxin reductase, putative 0.0182 0.0252 1
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0017 0.0002 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0016 0.0413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0016 0.0415
Toxoplasma gondii NADPH-glutathione reductase 0.0063 0.0072 0.2803
Loa Loa (eye worm) RNA binding protein 0.0069 0.0081 0.1037
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0017 0.0002 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0025 0.068
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0002 0.0037
Echinococcus granulosus Smad4 0.0017 0.0003 0.0002
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0011 0.0399
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0002 0.0037
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0027 0.0026
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0048 0.0049 0.0048
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0081 0.1037
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0462 0.0675 0.2068
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0119 0.0157 0.0156
Loa Loa (eye worm) hypothetical protein 0.016 0.0219 0.2812
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0088 0.3452
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0081 0.008
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0002 0.0025
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0137 0.0183 0.0182
Loa Loa (eye worm) MH2 domain-containing protein 0.0255 0.0363 0.4667
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0027 0.0352
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.002 0.0261
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.002 0.0261
Loa Loa (eye worm) transcription factor SMAD2 0.0255 0.0363 0.4667
Echinococcus multilocularis lamin 0.0029 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0025
Toxoplasma gondii thioredoxin reductase 0.0182 0.0252 1
Schistosoma mansoni apoferritin-2 0.0018 0.0004 0.0003
Onchocerca volvulus 0.0032 0.0025 0.0642
Mycobacterium ulcerans beta-lactamase 0.0073 0.0088 0.0263
Onchocerca volvulus 0.0254 0.036 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.016 0.0219 0.0218
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0081 0.008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0025 0.0024
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.016 0.0219 0.0664
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0002 0.0037
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0017 0.0002 0.0001
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0081 0.008
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0137 0.1762
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0072 0.283
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0002 0.0001
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0048 0.0049 0.3066
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0037
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0004 0.0007
Schistosoma mansoni thyroid hormone receptor 0.0148 0.02 0.0199
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0048 0.0049 0.1927
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0063 0.0072 0.0927
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0024 0.0636
Mycobacterium tuberculosis Conserved protein 0.0073 0.0088 0.0263
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0035 0.1336
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0025 0.0024
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0088 0.0263
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0416 0.0605 0.1849
Schistosoma mansoni survival motor neuron protein 0.0108 0.014 0.0139
Schistosoma mansoni hypothetical protein 0.0119 0.0157 0.0156
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0088 0.0263
Echinococcus multilocularis thioredoxin glutathione reductase 0.0183 0.0254 0.0253
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0088 0.3428
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0035 0.1336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0016 0.0415
Entamoeba histolytica hypothetical protein 0.0119 0.0157 1
Trypanosoma brucei NADH dehydrogenase 0.0017 0.0002 0.0037
Entamoeba histolytica hypothetical protein 0.0119 0.0157 1
Echinococcus granulosus lamin dm0 0.0029 0.002 0.0019
Schistosoma mansoni glutamate synthase 0.0017 0.0002 0.0001
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0088 0.0263
Schistosoma mansoni lamin 0.0029 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.053 0.0777 1
Schistosoma mansoni cellular tumor antigen P53 0.0209 0.0293 0.0292
Brugia malayi glutamate synthase 0.0017 0.0002 0.0025
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.016 0.0219 1
Onchocerca volvulus 0.0108 0.014 0.3852
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0081 0.008
Loa Loa (eye worm) hypothetical protein 0.0034 0.0027 0.0352
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0063 0.0072 0.283
Echinococcus multilocularis expressed protein 0.0018 0.0004 0.0003
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0027 0.0352
Trichomonas vaginalis esterase, putative 0.0073 0.0088 0.2413
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.016 0.0219 0.0664
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0018 0.0676
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0088 0.2413
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0018 0.0004 0.0112
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0002 0.0025
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0002 0.0001
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0063 0.0072 0.0215
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0002 0.0001
Plasmodium falciparum glutathione reductase 0.0182 0.0252 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0108 0.014 0.18
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0018 0.0641
Schistosoma mansoni hypothetical protein 0.0108 0.014 0.0139
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0031 0.1151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0519
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0018 0.0641
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0035 0.1336
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0017 0.0002 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0031 0.0827
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0018 0.0641
Brugia malayi RNA binding protein 0.0069 0.0081 0.1037
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0063 0.0072 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0072 0.283
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0018 0.0641
Echinococcus multilocularis ferritin 0.0018 0.0004 0.0003
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0063 0.0072 0.283
Plasmodium vivax SET domain protein, putative 0.0032 0.0025 0.092
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0027 0.0026
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0063 0.0072 0.283
Loa Loa (eye worm) hypothetical protein 0.0073 0.0088 0.1128
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0063 0.0072 0.0215
Schistosoma mansoni transcription factor LCR-F1 0.0119 0.0157 0.0156
Trichomonas vaginalis mercuric reductase, putative 0.0063 0.0072 0.1978
Echinococcus granulosus GPCR family 2 0.0034 0.0027 0.0026
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0002 0.0037
Brugia malayi MH2 domain containing protein 0.0017 0.0003 0.0038
Echinococcus granulosus ferritin 0.0018 0.0004 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0025 0.0024
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0088 0.1128
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0017 0.0002 0.0026
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0007 0.0232
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0088 0.0263
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0072 0.283
Mycobacterium ulcerans transcriptional regulator 0.2174 0.3263 1
Echinococcus multilocularis Smad4 0.0017 0.0003 0.0002
Entamoeba histolytica hypothetical protein 0.0119 0.0157 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0003 0.0002
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0063 0.0072 0.283
Brugia malayi MH1 domain containing protein 0.0017 0.0003 0.0038
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0025 0.0024
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0088 0.2413
Brugia malayi Pre-SET motif family protein 0.0032 0.0025 0.0321
Schistosoma mansoni glutamate synthase 0.0017 0.0002 0.0001
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0223 0.0314 0.4035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0034 0.0932
Brugia malayi MH1 domain containing protein 0.0017 0.0003 0.0038
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0063 0.0072 0.283
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0063 0.0072 0.283
Leishmania major hypothetical protein, conserved 0.0073 0.0088 0.3452
Echinococcus multilocularis survival motor neuron protein 1 0.053 0.0777 0.0776
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0016 0.0415
Schistosoma mansoni ferritin light chain 0.0018 0.0004 0.0003
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0001 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0049 0.1347
Echinococcus multilocularis GPCR, family 2 0.0034 0.0027 0.0026
Brugia malayi Probable ClpP-like protease 0.016 0.0219 0.2812
Onchocerca volvulus 0.0073 0.0088 0.2393
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.016 0.0219 1
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0088 0.2413
Giardia lamblia NADH oxidase lateral transfer candidate 0.0063 0.0072 1
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0017 0.0002 0.0001
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0002 0.0026
Schistosoma mansoni ferritin 0.0018 0.0004 0.0003
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0017 0.0002 0.0026
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0037
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0063 0.0072 0.2803
Treponema pallidum NADH oxidase 0.0063 0.0072 0.3237
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0081 0.008
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0003 0.0038
Schistosoma mansoni lamin 0.0029 0.002 0.0019
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0002 0.0037
Trichomonas vaginalis set domain proteins, putative 0.0254 0.036 1
Trichomonas vaginalis apoptosis inducing factor, putative 0.0017 0.0002 0.0026
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0063 0.0072 0.2803
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0088 0.2413
Schistosoma mansoni ferritin 0.0018 0.0004 0.0003
Schistosoma mansoni smad1 5 8 and 0.0017 0.0003 0.0002
Mycobacterium tuberculosis Conserved protein 0.0073 0.0088 0.0263
Brugia malayi TAR-binding protein 0.0069 0.0081 0.1037
Brugia malayi Smad1 0.0017 0.0003 0.0038
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0002 0.0037
Plasmodium vivax glutathione reductase, putative 0.0182 0.0252 1
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0017 0.0002 0.0001
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.0049 0.1927
Trypanosoma brucei trypanothione reductase 0.0182 0.0252 1
Echinococcus granulosus glutamate synthase 0.0017 0.0002 0.0001
Echinococcus multilocularis microtubule associated protein 2 0.663 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0049 0.0635
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0063 0.0072 0.283
Brugia malayi hypothetical protein 0.0119 0.0157 0.2016
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0088 0.3452
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0002 0.0026
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0063 0.0072 0.283
Mycobacterium ulcerans hypothetical protein 0.0073 0.0088 0.0263
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0072 0.283
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0002 0.0001
Echinococcus granulosus tar DNA binding protein 0.0069 0.0081 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0031 0.0827
Loa Loa (eye worm) Smad1 0.0017 0.0003 0.0038
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0027 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0034 0.0932
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0088 0.0263
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0017 0.0002 0.0001
Treponema pallidum bacterioferrin (TpF1) 0.0018 0.0004 0.0112
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0055 0.006 0.232
Schistosoma mansoni hypothetical protein 0.0034 0.0027 0.0026
Schistosoma mansoni hypothetical protein 0.0073 0.0086 0.0085
Onchocerca volvulus 0.0029 0.002 0.0512
Toxoplasma gondii ABC1 family protein 0.0073 0.0088 0.3428
Onchocerca volvulus 0.0073 0.0088 0.2393
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0416 0.0605 0.1853
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0025 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.002 0.0531
Schistosoma mansoni ferritin 0.0018 0.0004 0.0003
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0063 0.0072 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0031 0.0827
Brugia malayi intermediate filament protein 0.0029 0.002 0.0261
Loa Loa (eye worm) hypothetical protein 0.0073 0.0088 0.1128
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0063 0.0072 0.2803
Brugia malayi beta-lactamase 0.0073 0.0088 0.1128
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0048 0.0049 0.1927
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0037
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0088 0.0263
Brugia malayi MH2 domain containing protein 0.0255 0.0363 0.4667
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0018 0.0676
Schistosoma mansoni ferritin light chain 0.0018 0.0004 0.0003
Loa Loa (eye worm) thioredoxin reductase 0.0182 0.0252 0.3243
Echinococcus multilocularis tumor protein p63 0.1431 0.214 0.2139
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0137 0.1762
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0048 0.0049 0.0048
Echinococcus multilocularis smad 0.0017 0.0003 0.0002
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0025 0.0024
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0025 0.0024
Loa Loa (eye worm) beta-lactamase 0.0073 0.0088 0.1128
Plasmodium falciparum thioredoxin reductase 0.0063 0.0072 0.2803
Brugia malayi MH2 domain containing protein 0.0017 0.0003 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0031 0.0827
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0063 0.0072 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0031 0.0827
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0017 0.0002 0.0037
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0063 0.0072 0.3237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0031 0.0827
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0049 0.1347
Schistosoma mansoni hypothetical protein 0.0034 0.0027 0.0026
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0002 0.0026
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0081 0.1037
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0105 0.0135 0.0409
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0016 0.0413
Mycobacterium tuberculosis Probable dehydrogenase 0.0416 0.0605 0.1853
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.016 0.0219 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0063 0.0072 0.0215
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0003 0.0002
Giardia lamblia GTOR 0.0048 0.0049 0.6766
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0063 0.0072 0.0071
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0027 0.0026
Trypanosoma cruzi trypanothione reductase, putative 0.0182 0.0252 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0148 0.02 0.0199
Mycobacterium tuberculosis Conserved protein 0.0073 0.0088 0.0263
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0137 0.0183 0.0182
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0027 0.0352
Trichomonas vaginalis glutamate synthase, putative 0.0017 0.0002 0.0026
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0119 0.0157 0.0156
Schistosoma mansoni disulfide oxidoreductase 0.0017 0.0002 0.0001
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0063 0.0072 0.0071
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0063 0.0072 0.283
Brugia malayi beta-lactamase family protein 0.0073 0.0088 0.1128
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0055 0.006 0.0178
Echinococcus multilocularis peptidase Clp (S14 family) 0.0105 0.0135 0.0134
Loa Loa (eye worm) hypothetical protein 0.0106 0.0137 0.1762
Echinococcus granulosus tumor protein p63 0.1431 0.214 0.2139
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0462 0.0675 0.2068
Plasmodium falciparum thioredoxin reductase 0.0182 0.0252 1
Mycobacterium tuberculosis Probable reductase 0.0416 0.0605 0.1853
Loa Loa (eye worm) hypothetical protein 0.0073 0.0088 0.1128
Schistosoma mansoni smad 0.0017 0.0003 0.0002
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0017 0.0002 0.0025
Schistosoma mansoni glutamate synthase 0.0017 0.0002 0.0001
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0088 0.0087
Loa Loa (eye worm) programmed cell death 8 0.0017 0.0002 0.0025
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0004 0.0007
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0088 0.1128
Trichomonas vaginalis glutathione reductase, putative 0.0063 0.0072 0.1978
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0063 0.0072 0.3237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0031 0.0827
Brugia malayi Thioredoxin reductase 0.0182 0.0252 0.3243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0049 0.1347
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0018 0.0676
Echinococcus granulosus expressed protein 0.0018 0.0004 0.0003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0072 0.283
Loa Loa (eye worm) intermediate filament protein 0.0029 0.002 0.0261
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0182 0.0252 0.0768
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0002 0.0037
Schistosoma mansoni microtubule-associated protein tau 0.663 1 1
Entamoeba histolytica hypothetical protein 0.0119 0.0157 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0063 0.0072 0.2803
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0055 0.006 0.232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.002 0.0531
Schistosoma mansoni hypothetical protein 0.0137 0.0183 0.0182
Schistosoma mansoni hypothetical protein 0.0034 0.0027 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.002 0.0519
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0048 0.0049 0.1927
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0017 0.0002 0.0037
Trypanosoma cruzi trypanothione reductase, putative 0.0063 0.0072 0.283
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.0261
Plasmodium falciparum glutathione reductase 0.0063 0.0072 0.2803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0034 0.0932
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0469 0.0686 0.2102
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0002 0.0026
Brugia malayi hypothetical protein 0.0027 0.0018 0.0231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0034 0.0932
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0105 0.0135 0.0409
Schistosoma mansoni Smad4 0.0017 0.0003 0.0002
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0017 0.0002 0.0026
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2169 0.3256 1
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0017 0.0002 0.0037
Brugia malayi hypothetical protein 0.0018 0.0003 0.0043
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0321
Leishmania major trypanothione reductase 0.0182 0.0252 1
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0088 0.2413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0016 0.0413
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0462 0.0675 0.2064
Onchocerca volvulus 0.0073 0.0088 0.2393
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0002 0.0037
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0025 0.092
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.016 0.0219 0.866
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.016 0.0219 0.866
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0063 0.0072 0.3237
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0088 0.0087
Mycobacterium tuberculosis Probable oxidoreductase 0.0462 0.0675 0.2068
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0088 0.0087
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0017 0.0002 0.0001
Trichomonas vaginalis glutamate synthase, putative 0.0017 0.0002 0.0026
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0251
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0072 0.283
Schistosoma mansoni apoferritin-2 0.0018 0.0004 0.0003
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.016 0.0219 0.0218
Mycobacterium leprae Probable lipase LipE 0.0073 0.0088 0.0263
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0088 0.0263
Loa Loa (eye worm) hypothetical protein 0.0073 0.0088 0.1128
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0046 0.0047 0.0601
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0002 0.0001
Schistosoma mansoni intermediate filament proteins 0.0029 0.002 0.0019
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0105 0.0135 0.0409
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0048 0.0049 0.1927
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0002 0.0037
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0018 0.0004 0.0007
Toxoplasma gondii hypothetical protein 0.0055 0.006 0.232
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0088 0.0263
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.016 0.0219 0.866
Echinococcus granulosus intermediate filament protein 0.0029 0.002 0.0019
Echinococcus multilocularis musashi 0.0029 0.002 0.0019
Schistosoma mansoni smad1 5 8 and 0.0017 0.0003 0.0002
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0002 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.002 0.0531
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2174 0.3263 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0049 0.0635
Onchocerca volvulus 0.0209 0.0293 0.8133
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0017 0.0002 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0034 0.0932
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0016 0.0415
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0003 0.0002
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0023 0.0022
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0003 0.0002
Onchocerca volvulus 0.0029 0.002 0.0512
Echinococcus granulosus thioredoxin glutathione reductase 0.0183 0.0254 0.0253
Brugia malayi glutathione reductase 0.0182 0.0252 0.3243
Echinococcus granulosus survival motor neuron protein 1 0.053 0.0777 0.0776
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0001 0.0013
Brugia malayi Pre-SET motif family protein 0.0223 0.0314 0.4035
Loa Loa (eye worm) glutathione reductase 0.0182 0.0252 0.3243
Trichomonas vaginalis ferritin, putative 0.0018 0.0004 0.0094
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0004 0.0007
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.016 0.0219 0.866
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0048 0.0049 0.1927
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0086 0.1109
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0081 0.1037
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0137 0.1762
Echinococcus granulosus peptidase Clp S14 family 0.0105 0.0135 0.0134
Loa Loa (eye worm) hypothetical protein 0.0073 0.0086 0.1109
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.016 0.0219 1
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0017 0.0002 0.0001
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0002 0.0001
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0004 0.0007
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0088 0.0263
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0017 0.0002 0.0001
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0055 0.006 0.2679
Echinococcus granulosus smad 0.0017 0.0003 0.0002
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0003 0.0002

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.