Detailed information for compound 594476

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 594.667 | Formula: C33H37F3N4O3
  • H donors: 2 H acceptors: 4 LogP: 4.27 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(F)(F)F.N#Cc1cccc(c1)CN1CCCN(CC1)Cc1cccc(c1)C(=O)Nc1ccc(cc1)C(C)(C)C
  • InChi: 1S/C31H36N4O.C2HF3O2/c1-31(2,3)28-11-13-29(14-12-28)33-30(36)27-10-5-9-26(20-27)23-35-16-6-15-34(17-18-35)22-25-8-4-7-24(19-25)21-32;3-2(4,5)1(6)7/h4-5,7-14,19-20H,6,15-18,22-23H2,1-3H3,(H,33,36);(H,6,7)
  • InChiKey: OKLLYKGNTOATFH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0037 0.0381 0.0577
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0035 0.0348 0.0348
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.0855 0.0855
Echinococcus multilocularis epidermal growth factor receptor 0.0059 0.0697 0.0697
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0035 0.0348 0.0348
Schistosoma mansoni hypothetical protein 0.0038 0.0395 0.0395
Schistosoma mansoni cpg binding protein 0.0061 0.0719 0.0719
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.01 0.01
Brugia malayi hypothetical protein 0.0035 0.0348 0.0348
Echinococcus granulosus neuropeptide receptor A26 0.0523 0.7363 0.7363
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0866 0.0866
Loa Loa (eye worm) beta-lactamase 0.0071 0.0866 0.0866
Schistosoma mansoni ap endonuclease 0.0038 0.0387 0.0387
Echinococcus multilocularis neuropeptide receptor A26 0.0523 0.7363 0.7363
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0071 0.0866 0.0866
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0348 0.0348
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0185 0.2496 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0348 0.0348
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0866 0.1928
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0035 0.0348 0.0348
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0142 0.189 1
Brugia malayi hypothetical protein 0.0035 0.0348 0.0348
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0348 0.0348
Onchocerca volvulus 0.0035 0.0348 0.0484
Echinococcus granulosus neuropeptide s receptor 0.0523 0.7363 0.7363
Giardia lamblia Protein tyrosine phosphatase 0.0035 0.0348 0.0498
Onchocerca volvulus 0.0237 0.3249 0.4517
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0866 0.4277
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0035 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0037 0.0381 0.053
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0348 0.0348
Schistosoma mansoni ets-related 0.0213 0.2909 0.2909
Loa Loa (eye worm) insulin-degrading enzyme 0.0027 0.0232 0.0232
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0035 0.0348 0.0348
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0185 0.2496 0.5653
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.014 0.014
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 6 homolog 0.0037 0.0381 0.053
Onchocerca volvulus GPI ethanolamine phosphate transferase 2 homolog 0.0037 0.0381 0.053
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0035 0.0348 0.0348
Onchocerca volvulus 0.0035 0.0348 0.0484
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1203 0.1203
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.01 0.01
Onchocerca volvulus 0.0035 0.0348 0.0484
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0035 0.0348 0.0348
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0426 0.0426
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0035 0.0348 0.0348
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1203 0.1203
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0035 0.0348 0.0348
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0719 0.0719
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0387 0.0387
Echinococcus granulosus GA binding protein alpha chain 0.007 0.0855 0.0855
Onchocerca volvulus 0.0035 0.0348 0.0484
Chlamydia trachomatis insulinase family protease III 0.0027 0.0232 0.5
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0063 0.0063
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.4308 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0381 0.0381
Brugia malayi CXXC zinc finger family protein 0.0061 0.0719 0.0719
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0387 0.0805
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.014 0.0224
Loa Loa (eye worm) hypothetical protein 0.0237 0.3249 0.3249
Onchocerca volvulus 0.0035 0.0348 0.0484
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.01 0.0279
Loa Loa (eye worm) hypothetical protein 0.0071 0.0866 0.0866
Echinococcus granulosus 5'partial|nardilysin 0.0012 0.0017 0.0017
Schistosoma mansoni DNA polymerase eta 0.0021 0.014 0.014
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1203 0.1203
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.014 0.0497
Brugia malayi hypothetical protein 0.0037 0.0381 0.0381
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0348 0.0348
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0035 0.0348 0.0348
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.014 0.0497
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0866 0.1222
Brugia malayi hypothetical protein 0.0037 0.0381 0.0381
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0348 0.0348
Schistosoma mansoni hypothetical protein 0.0037 0.0381 0.0381
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0866 0.1928
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0707 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0395 0.0395
Onchocerca volvulus 0.0035 0.0348 0.0484
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0707 1 1
Onchocerca volvulus 0.0035 0.0348 0.0484
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0116 0.0116
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0037 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Echinococcus multilocularis cpg binding protein 0.0064 0.0769 0.0769
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.4308 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0348 0.0348
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.014 0.0064
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0387 0.3746
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0866 0.1928
Treponema pallidum fructose-bisphosphate aldolase 0.0311 0.4308 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0116 0.0116
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0866 0.1222
Schistosoma mansoni tyrosine kinase 0.0059 0.0697 0.0697
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0237 0.3249 0.3249
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0037 0.0381 0.0381
Echinococcus multilocularis G protein coupled receptor 139 0.0122 0.1596 0.1596
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0185 0.2496 0.5752
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.1599 0.1599
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0152 0.2026 0.8001
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0237 0.3249 0.3249
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.014 0.014
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0348 0.0348
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0866 0.308
Onchocerca volvulus 0.0035 0.0348 0.0484
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0035 0.0348 0.1383
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0063 0.0063
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0387 0.1602
Schistosoma mansoni hypothetical protein 0.0037 0.0381 0.0381
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0185 0.2496 0.5752
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0035 0.0348 0.0348
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0035 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0037 0.0381 0.0381
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0866 1
Toxoplasma gondii ABC1 family protein 0.0071 0.0866 0.4531
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0348 0.0348
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.0237 0.3249 0.3249
Echinococcus granulosus X box binding protein 1 0.0323 0.4489 0.4489
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.014 0.0497
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.01 0.01
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0035 0.0348 0.0348
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1203 0.1203
Leishmania major hypothetical protein, conserved 0.0071 0.0866 0.4277
Echinococcus granulosus insulin receptor 0.013 0.1717 0.1717
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0387 0.1047
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0387 1
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0037 0.0381 0.0381
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0035 0.0348 0.0348
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0866 0.1928
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Onchocerca volvulus 0.0035 0.0348 0.0484
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.01 0.01
Echinococcus multilocularis 0.0035 0.0348 0.0348
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0035 0.0348 0.0348
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.01 0.01
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.014 0.014
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0237 0.3249 0.3249
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0035 0.0348 0.1383
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0649 0.0649
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0035 0.0348 0.0348
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0037 0.0381 0.0577
Echinococcus granulosus nardilysin 0.0027 0.0232 0.0232
Trypanosoma brucei GPI ethanolamine phosphate transferase 3, putative 0.0037 0.0381 0.1804
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0035 0.0348 0.0348
Echinococcus multilocularis gpi ethanolamine phosphate transferase 3 0.0037 0.0381 0.0381
Onchocerca volvulus 0.0035 0.0348 0.0484
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0035 0.0348 0.0348
Onchocerca volvulus 0.0035 0.0348 0.0484
Onchocerca volvulus 0.0237 0.3249 0.4517
Echinococcus multilocularis gpi ethanolamine phosphate transferase 1 0.0037 0.0381 0.0381
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.014 0.0497
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1203 0.1203
Loa Loa (eye worm) hypothetical protein 0.0071 0.0866 0.0866
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0027 0.0232 0.0232
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0387 0.0592
Loa Loa (eye worm) hypothetical protein 0.0071 0.0866 0.0866
Echinococcus multilocularis nardilysin 0.0027 0.0232 0.0232
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0348 0.0348
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.014 0.0224
Schistosoma mansoni tyrosine kinase 0.0059 0.0697 0.0697
Schistosoma mansoni hypothetical protein 0.0018 0.01 0.01
Schistosoma mansoni protein tyrosine phosphatase 0.0035 0.0348 0.0348
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0348 0.0348
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.014 0.0497
Mycobacterium ulcerans hypothetical protein 0.0037 0.0381 0.1021
Leishmania major hypothetical protein, conserved 0.0057 0.0663 0.3142
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0348 0.0348
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0035 0.0348 0.0348
Brugia malayi beta-lactamase 0.0071 0.0866 0.0866
Echinococcus granulosus cpg binding protein 0.0064 0.0769 0.0769
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.01 0.01
Brugia malayi beta-lactamase family protein 0.0071 0.0866 0.0866
Brugia malayi Protein-tyrosine phosphatase 1 0.0035 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0348 0.0348
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0035 0.0348 0.0498
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0185 0.2496 0.5752
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0035 0.0348 0.0348
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.01 0.01
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0035 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0071 0.0866 0.0866
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.4308 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0348 0.0348
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0387 0.1837
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0866 0.308
Echinococcus multilocularis Alkaline phosphatase, core domain 0.0037 0.0381 0.0381
Onchocerca volvulus GPI ethanolamine phosphate transferase 3 homolog 0.0037 0.0381 0.053
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0512 0.7193 0.7193
Echinococcus granulosus insulin growth factor 1 receptor beta 0.013 0.1717 0.1717
Leishmania major tyrosine specific protein phosphatase, putative 0.0035 0.0348 0.1383
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1203 0.1203
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0237 0.3249 0.3249
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Giardia lamblia Fructose-bisphosphate aldolase 0.0311 0.4308 1
Schistosoma mansoni tyrosine kinase 0.013 0.1717 0.1717
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0237 0.3249 0.3249
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.1501 0.7922
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0348 0.0348
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0707 1 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0035 0.0348 0.0348
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0348 0.0348
Schistosoma mansoni tyrosine kinase 0.0058 0.0682 0.0682
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0866 0.1928
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0387 0.0458
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0063 0.0063
Onchocerca volvulus 0.0035 0.0348 0.0484
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0027 0.0232 0.0232
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0866 0.0866
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0035 0.0348 0.0348
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1203 0.1203
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.014 0.0497
Echinococcus multilocularis nardilysin 0.0027 0.0232 0.0232
Echinococcus granulosus dna polymerase eta 0.0021 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0866 0.1222
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0866 0.0866
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.014 0.0497
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0237 0.3249 0.3249
Loa Loa (eye worm) hypothetical protein 0.0021 0.014 0.014
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.01 0.0444
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0035 0.0348 0.0348
Schistosoma mansoni tyrosine kinase 0.013 0.1717 0.1717
Onchocerca volvulus 0.0035 0.0348 0.0484
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.014 0.0497
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0059 0.0697 0.0697
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0035 0.0348 0.0348
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0035 0.0348 0.0348
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0035 0.0348 0.0348
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.014 0.0497
Echinococcus multilocularis dna polymerase kappa 0.0021 0.014 0.014
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0348 0.0348
Leishmania major phosphoglycan beta 1,3 galactosyltransferase 5 0.0027 0.0232 0.0735
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0035 0.0348 0.0348
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0128 0.1679 0.2521
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0037 0.0381 0.0381
Onchocerca volvulus 0.0035 0.0348 0.0484
Brugia malayi hypothetical protein 0.0035 0.0348 0.0348
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0035 0.0348 0.0348
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0035 0.0348 0.0348
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0035 0.0348 0.0348
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0035 0.0348 0.0348
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.014 0.0497
Echinococcus multilocularis dna polymerase eta 0.0021 0.014 0.014
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0387 0.0592
Schistosoma mansoni cpg binding protein 0.0064 0.0769 0.0769
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Plasmodium falciparum GPI ethanolamine phosphate transferase 3, putative 0.0037 0.0381 0.9786
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0035 0.0348 0.0348
Brugia malayi Isocitrate dehydrogenase 0.0018 0.01 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.014 0.0497
Onchocerca volvulus 0.0071 0.0866 0.1204
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0663 0.3142
Schistosoma mansoni tyrosine kinase 0.0058 0.0682 0.0682
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0063 0.0063
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.4308 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0035 0.0348 0.0348
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0185 0.2496 0.2496
Leishmania major ethanolamine phosphotransferase, putative 0.0037 0.0381 0.1568
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0035 0.0348 0.0348
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.01 0.01
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.014 0.0227
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.01 0.01
Schistosoma mansoni hypothetical protein 0.0512 0.7193 0.7193
Schistosoma mansoni neuropeptide receptor 0.0122 0.1596 0.1596
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0866 0.0866
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Brugia malayi beta-lactamase family protein 0.0071 0.0866 0.0866
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0185 0.2496 0.5752
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.01 0.0444
Schistosoma mansoni cpg binding protein 0.0064 0.0769 0.0769
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.01 0.01
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0387 0.5
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.01 0.0279
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0311 0.4308 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.02 0.2714 0.2714
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Toxoplasma gondii rhoptry metalloprotease toxolysin TLN1 0.0027 0.0232 0.1146
Toxoplasma gondii sporozoite developmental protein 0.0027 0.0232 0.1146
Brugia malayi MH2 domain containing protein 0.0122 0.1599 0.1599
Echinococcus granulosus 3'partial|nardilysin 0.0027 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.1699 0.1699
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0387 0.0387
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0152 0.2026 0.3074
Echinococcus multilocularis Endonuclease G 0.0142 0.189 0.189
Echinococcus multilocularis nardilysin 0.0016 0.0079 0.0079
Schistosoma mansoni gabp alpha 0.007 0.0855 0.0855
Echinococcus multilocularis hypothetical protein 0.0035 0.0348 0.0348
Onchocerca volvulus 0.0071 0.0866 0.1204
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0035 0.0348 0.0348
Brugia malayi Furin-like cysteine rich region family protein 0.0059 0.0697 0.0697
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0387 0.1602
Brugia malayi hypothetical protein 0.004 0.0426 0.0426
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.4308 1
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0113 0.0113
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0866 0.1222
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0348 0.0348
Schistosoma mansoni nardilysin (M16 family) 0.0027 0.0232 0.0232
Leishmania major endonuclease G, putative 0.0142 0.189 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0035 0.0348 0.0348
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0387 0.1602
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0185 0.2496 0.2496
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0037 0.0381 0.0381
Loa Loa (eye worm) protein tyrosine phosphatase 0.0035 0.0348 0.0348
Brugia malayi Protein kinase domain containing protein 0.013 0.1717 0.1717
Brugia malayi Thrombospondin type 1 domain containing protein 0.0512 0.7193 0.7193
Loa Loa (eye worm) hypothetical protein 0.0038 0.0395 0.0395
Trypanosoma cruzi endonuclease G, putative 0.0142 0.189 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0237 0.3249 0.3249
Schistosoma mansoni hypothetical protein 0.0018 0.01 0.01
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0035 0.0348 0.0348
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0237 0.3249 0.3249
Brugia malayi Ets-domain containing protein 0.007 0.0855 0.0855
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0185 0.2496 0.5653
Loa Loa (eye worm) TK/INSR protein kinase 0.013 0.1717 0.1717
Echinococcus multilocularis transferase 0.0037 0.0381 0.0381
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.0142 0.189 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.1599 0.1599
Schistosoma mansoni hypothetical protein 0.004 0.0426 0.0426
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.014 0.014
Onchocerca volvulus 0.0035 0.0348 0.0484
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0237 0.3249 0.3249
Brugia malayi hypothetical protein 0.0035 0.0348 0.0348
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.01 0.01
Onchocerca volvulus 0.0512 0.7193 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0035 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0071 0.0866 0.0866
Onchocerca volvulus 0.0185 0.2496 0.3471
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0035 0.0348 0.1383
Schistosoma mansoni hypothetical protein 0.0323 0.4489 0.4489
Loa Loa (eye worm) hypothetical protein 0.0018 0.01 0.01
Entamoeba histolytica hypothetical protein 0.004 0.0426 0.0684
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0866 0.2949
Echinococcus granulosus GPCR family 2 0.0018 0.01 0.01
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0035 0.0348 0.0498
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0866 0.4277
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0866 0.1222
Mycobacterium leprae Probable lipase LipE 0.0071 0.0866 0.2949
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0348 0.0348
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.014 0.0224
Onchocerca volvulus 0.0035 0.0348 0.0484
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.014 0.0497
Trypanosoma brucei peptidase, putative 0.0027 0.0232 0.0993
Trypanosoma cruzi endonuclease G, putative 0.0142 0.189 1
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.0142 0.189 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.006 0.0708 0.0708
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.014 0.0224
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0035 0.0348 0.0348
Entamoeba histolytica hypothetical protein 0.004 0.0426 0.0684
Echinococcus multilocularis 0.0017 0.009 0.009
Schistosoma mansoni hypothetical protein 0.0018 0.01 0.01
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.02 0.2714 0.2714
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0348 0.0348
Brugia malayi endonuclease G, mitochondrial precursor 0.0142 0.189 0.189
Brugia malayi Protein-tyrosine phosphatase 0.0035 0.0348 0.0348
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0057 0.0663 0.1452
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0866 0.0866
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.014 0.0497
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0035 0.0348 0.0348
Echinococcus multilocularis ectonucleotide 0.02 0.2714 0.2714
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0237 0.3249 0.3249
Echinococcus multilocularis insulin receptor 0.013 0.1717 0.1717
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0649 0.0649
Trypanosoma brucei endonuclease G, putative 0.0142 0.189 1
Onchocerca volvulus 0.0035 0.0348 0.0484
Entamoeba histolytica hypothetical protein 0.004 0.0426 0.0684
Trypanosoma brucei endonuclease G, putative 0.0142 0.189 1
Schistosoma mansoni ap endonuclease 0.0038 0.0387 0.0387
Echinococcus granulosus gpi ethanolamine phosphate transferase 3 0.0037 0.0381 0.0381
Echinococcus multilocularis neuropeptide receptor 0.0122 0.1596 0.1596
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0035 0.0348 0.1383
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0035 0.0348 0.0348
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0387 0.0805
Onchocerca volvulus 0.0035 0.0348 0.0484
Mycobacterium ulcerans beta-lactamase 0.0071 0.0866 0.308
Trichomonas vaginalis pten, drome, putative 0.0035 0.0348 0.0713
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0035 0.0348 0.0348
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0237 0.3249 0.3249
Echinococcus multilocularis epidermal growth factor receptor 0.0059 0.0697 0.0697
Echinococcus multilocularis insulin degrading enzyme 0.0027 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0037 0.0381 0.0381
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.01 0.01
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0237 0.3249 0.3249
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1203 0.1203
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0056 0.0649 0.0649
Onchocerca volvulus 0.0035 0.0348 0.0484
Brugia malayi Latrophilin receptor protein 2 0.0018 0.01 0.01
Echinococcus granulosus epidermal growth factor receptor 0.0059 0.0697 0.0697
Trypanosoma brucei unspecified product 0.0021 0.014 0.0497
Echinococcus granulosus ectonucleotide 0.02 0.2714 0.2714
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.014 0.014
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0185 0.2496 0.5752
Toxoplasma gondii insulysin, putative 0.0026 0.0213 0.1045
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0035 0.0348 0.0348
Brugia malayi Ets-domain containing protein 0.007 0.0855 0.0855
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.014 0.0064
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0348 0.0348
Trypanosoma cruzi peptidase, putative 0.0027 0.0232 0.0735
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0035 0.0348 0.0348
Echinococcus granulosus neuropeptide receptor 0.0122 0.1596 0.1596
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0348 0.0348
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0707 1 1
Onchocerca volvulus 0.0035 0.0348 0.0484
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.01 0.01
Brugia malayi Protein-tyrosine phosphatase 0.0035 0.0348 0.0348
Echinococcus multilocularis GPCR, family 2 0.0018 0.01 0.01
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0035 0.0348 0.0348
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.01 0.01
Brugia malayi AEL166Cp 0.0037 0.0381 0.0381
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.014 0.014
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0057 0.0663 0.1452
Brugia malayi isocitrate dehydrogenase 0.0018 0.01 0.01
Schistosoma mansoni insulysin (M16 family) 0.0015 0.006 0.006
Onchocerca volvulus 0.0035 0.0348 0.0484
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0057 0.0663 0.3334
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.014 0.0224
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0035 0.0348 0.0348
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1203 0.1203
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0348 0.0348
Onchocerca volvulus 0.0035 0.0348 0.0484
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0663 0.3142
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0152 0.2026 1
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0035 0.0348 0.0498
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0035 0.0348 0.0348
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0237 0.3249 0.3249
Mycobacterium ulcerans lipase LipD 0.0071 0.0866 0.308
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0035 0.0348 0.0348
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0454 0.6364 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0348 0.0348
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0142 0.189 1
Brugia malayi Protein kinase domain containing protein 0.0072 0.0881 0.0881
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0348 0.0348
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Onchocerca volvulus 0.0061 0.0719 0.1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.014 0.0497
Echinococcus granulosus epidermal growth factor receptor 0.0059 0.0697 0.0697
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0071 0.0866 0.0866
Echinococcus granulosus Endonuclease G 0.0142 0.189 0.189
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0426 0.0426
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0348 0.0348
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0866 0.1222
Brugia malayi hypothetical protein 0.0035 0.0348 0.0348
Onchocerca volvulus 0.0035 0.0348 0.0484
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0348 0.0348
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0348 0.0348
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0035 0.0348 0.0348
Echinococcus granulosus protein tyrosine phosphatase n9 0.0035 0.0348 0.0348
Schistosoma mansoni protein tyrosine phosphatase 0.0035 0.0348 0.0348
Schistosoma mansoni hypothetical protein 0.0037 0.0381 0.0381
Mycobacterium tuberculosis Conserved protein 0.0071 0.0866 0.1222
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0311 0.4308 1
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0035 0.0348 0.0348
Schistosoma mansoni protein tyrosine phosphatase 0.0035 0.0348 0.0348
Loa Loa (eye worm) fli-1 protein 0.0213 0.2909 0.2909
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0866 0.1222
Loa Loa (eye worm) TK/EGFR protein kinase 0.0059 0.0697 0.0697
Onchocerca volvulus 4.1 G protein, putative homolog 0.0035 0.0348 0.0484
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0237 0.3249 0.3249
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0035 0.0348 0.0348
Brugia malayi insulin-degrading enzyme 0.0027 0.0232 0.0232
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.4308 1
Loa Loa (eye worm) type I phosphodiesterase/nucleotide pyrophosphatase 0.0037 0.0381 0.0381
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0866 0.4437
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0035 0.0348 0.0348
Toxoplasma gondii peptidase M16 inactive domain-containing protein 0.0016 0.0079 0.0332
Echinococcus multilocularis neuropeptide s receptor 0.0523 0.7363 0.7363
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.0348 0.0348
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0035 0.0348 0.0348
Entamoeba histolytica hypothetical protein 0.004 0.0426 0.0684
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.4308 1
Echinococcus multilocularis X box binding protein 1 0.0323 0.4489 0.4489
Toxoplasma gondii exonuclease III APE 0.0038 0.0387 0.1975
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0866 0.0866
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.0855 0.0855
Schistosoma mansoni hypothetical protein 0.0018 0.01 0.01
Onchocerca volvulus 0.0071 0.0866 0.1204
Trypanosoma brucei protein tyrosine phosphatase 1 0.0035 0.0348 0.1623
Leishmania major DNA polymerase kappa, putative 0.0021 0.014 0.0224
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0237 0.3249 0.3249
Echinococcus granulosus transferase 0.0037 0.0381 0.0381
Schistosoma mansoni hypothetical protein 0.0037 0.0381 0.0381
Trypanosoma brucei endonuclease G, putative 0.0142 0.189 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Schistosoma mansoni endonuclease related 0.0142 0.189 0.189
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0035 0.0348 0.0348
Echinococcus granulosus dna polymerase kappa 0.0021 0.014 0.014
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0035 0.0348 0.0348
Schistosoma mansoni nardilysin (M16 family) 0.0027 0.0232 0.0232
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0185 0.2496 0.5653
Schistosoma mansoni tyrosine kinase 0.0059 0.0697 0.0697
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0348 0.0348
Mycobacterium tuberculosis Conserved protein 0.0071 0.0866 0.1222
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0649 0.0649
Trichomonas vaginalis esterase, putative 0.0071 0.0866 0.1928
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0348 0.0348
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0237 0.3249 0.3249
Giardia lamblia Phosphatidylinositol-glycan biosynthesis, class O protein 0.0037 0.0381 0.0577
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0348 0.0348
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0426 0.0426
Leishmania major DNA polymerase eta, putative 0.0021 0.014 0.0224
Mycobacterium tuberculosis Conserved protein 0.0071 0.0866 0.1222
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.4308 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.02 0.2714 0.2714
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.0348 0.0348
Trypanosoma cruzi peptidase, putative 0.0027 0.0232 0.0735
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0348
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.013 0.1717 0.1717
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0185 0.2496 0.5752
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0237 0.3249 0.3249
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.014 0.0227
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0035 0.0348 0.0348
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0035 0.0348 0.0348
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 7 homolog 0.0037 0.0381 0.053
Echinococcus granulosus insulin degrading enzyme 0.0027 0.0232 0.0232
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.014 0.0224
Schistosoma mansoni pcd6 interacting protein-related 0.0035 0.0348 0.0348
Brugia malayi Fli-1 protein 0.0213 0.2909 0.2909
Schistosoma mansoni tyrosine kinase 0.0058 0.0682 0.0682
Mycobacterium ulcerans hypothetical protein 0.0071 0.0866 0.308
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0387 0.0387

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0.63 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 1.26 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 4 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 5.1 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 12 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 39 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 97 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 7.75 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = 4 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 12 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 39 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 97 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.12 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.75506 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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